Search Result
Results for "
metal chelator
" in MedChemExpress (MCE) Product Catalog:
5
Biochemical Assay Reagents
3
Isotope-Labeled Compounds
Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-16739
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- HY-D0261
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- HY-D1746
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EDTA acetoxymethyl ester; Ethylenediaminetetraacetic acid acetoxymethyl ester
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Biochemical Assay Reagents
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Others
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EDTA-AM (ethylenediaminetetraacetic acid, acetoxymethyl ester) is the membrane-permeant form of the metal chelator EDTA (HY-Y0682). Live cells passively load EDTA-AM by incubating with EDTA-AM. Once internalized, cytoplasmic esterase decomposes AM esters, releasing the active ligand EDTA, which isolates metal ions within the cell. EDTA-AM induces an arrest of mitotic progression and chromosome decondensation .
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- HY-D1641
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Fluorescent Dye
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Others
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5,5'-Dimethyl BAPTA tetrapotassium is a water-soluble, extracellular membrane metal chelator with relative selectivity for calcium ions .
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- HY-128370
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Ca-DTPA trisodium salt hydrate
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CMV
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Infection
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Calcium trinatrium diethylenetriaminepentaacetic acid hydrate (Ca-DTPA trisodium salt hydrate) is a metal chelator and a useful antidote (such as acute cadmium intoxication). Diethylenetriaminepentaacetic acid calcium trisodium salt hydrate is a nontoxic inhibitor of CMV replication .
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- HY-18670
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- HY-45290
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Biochemical Assay Reagents
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Others
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trans-1,2-Cyclohexanediaminetetraacetic acid is a commonly used aminopolycarboxylic acid and a strong chelator of heavy metal ions .
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- HY-20512
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Biochemical Assay Reagents
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Others
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N,N'-Dibenzylethylenediamine forms chelator with metals. N,N'-Dibenzylethylenediamine interacts with penicillin, forms a stable and tasteless salt of penicillin .
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- HY-157977
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Biochemical Assay Reagents
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Others
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DOTA-GA-maleimide is a macrocyclic chelator, which forms stable complex with metals. DOTA-GA-maleimide is utilized as radiolabelled imaging agent .
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- HY-147962
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Cholinesterase (ChE)
HDAC
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Neurological Disease
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COX-2-IN-23 (compound A10) is a potent both AChE and HDAC inhibitor with IC50 values of 0.12 and 0.23 nM. COX-2-IN-23 exhibits antioxidant activity and metal chelating properties. COX-2-IN-23 can be used in alzheimer's disease research .
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- HY-Y0682S
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Ethylenediaminetetraacetic acid-d12
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Isotope-Labeled Compounds
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Neurological Disease
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EDTA-d12 is the deuterium labeled Ethylenediaminetetraacetic acid[1]. Ethylenediaminetetraacetic acid (EDTA) is a metal chelators (binds to metal divalent and trivalent cations including calcium), which shows activities of anticoagulant and anti-hypercalcemic. Ethylenediaminetetraacetic acid decreases the metal ion-catalyzed oxidative damage to proteins, and allows maintenance of reducing environment during protein purification. Ethylenediaminetetraacetic acid can also decrease the formation of disulfide bonds[2][3][4].
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- HY-145888
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Amyloid-β
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Neurological Disease
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Antioxidant agent-2 (comp 3c), an BBB-penetrated antioxidant agent and a selective metal ions chelator, presents good neuroprotective effect and hepatoprotective effect for the study of Alzheimer’s disease .
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- HY-Y0682S1
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EDTA-d16
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Isotope-Labeled Compounds
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Neurological Disease
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Ethylenediaminetetraacetic acid-d16 is the deuterium labeled Ethylenediaminetetraacetic acid[1]. Ethylenediaminetetraacetic acid (EDTA) is a metal chelators (binds to metal divalent and trivalent cations including calcium), which shows activities of anticoagulant and anti-hypercalcemic. Ethylenediaminetetraacetic acid decreases the metal ion-catalyzed oxidative damage to proteins, and allows maintenance of reducing environment during protein purification. Ethylenediaminetetraacetic acid can also decrease the formation of disulfide bonds[2][3][4].
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- HY-103528
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Salicylidene salicylhydrazide
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GABA Receptor
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Neurological Disease
Inflammation/Immunology
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SCS (Salicylidene salicylhydrazide) is a potent, allosteric and selective inhibitor of β1-containing GABAA receptors with an IC50 of 32 nM against α2β1γ1θ by VIPR measurement. SCS is also a chelator of metal ions .
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- HY-Y1841
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1,10-Phenanthroline monohydrate
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MMP
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Others
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o-Phenanthroline (1,10-Phenanthroline) monohydrate, a metal chelator, prevents the induction of chromosomal aberrations in streptozotocin-treated cells. o-Phenanthroline monohydrate forms a red chelate with Fe 2+ that absorbs maximally at 510 nm. o-Phenanthroline (1,10-Phenanthroline) monohydrate is also a MMP inhibitor .
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- HY-N0928
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Apoptosis
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Inflammation/Immunology
Cancer
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Mimosine, a tyrosine analog , can act as an antioxidant by its potent iron-binding activity . Mimosine is a known chelator of Fe(III) . Mimosine induces apoptosis through metal ion chelation, mitochondrial activation and ROS production in human leukemic cells . Anti-cancer, antiinflammation.
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- HY-100202
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TPEDA
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Reactive Oxygen Species
Apoptosis
Autophagy
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Cancer
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TPEN (TPEDA) is a specific cell-permeable heavy metal chelator. TPEN has a higher affinity for Zn 2+, but a lower affinity for Mg 2+ and Ca 2+. TPEN induces DNA damage and increases intracellular ROS production. TPEN also inhibits cell proliferation and induces apoptosis .
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- HY-W004544
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1,10-Phenanthroline
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MMP
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Others
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o-Phenanthroline (1,10-Phenanthroline), a metal chelator, prevents the induction of chromosomal aberrations in streptozotocin-treated cells. o-Phenanthroline (1,10-Phenanthroline) forms a red chelate with Fe 2+ that absorbs maximally at 510 nm. o-Phenanthroline (1,10-Phenanthroline) is also a MMP inhibitor .
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- HY-W011060
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4,7,13,16,21,24-Hexaoxa-1,10-diazabicyclo[8.8.8]hexacosane
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Biochemical Assay Reagents
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Others
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Cryptand 2.2.2 is a metal ion chelator that can be used as a reducing agent and stabilizer to prepare nanoparticles. At room temperature, Cryptand 2.2.2 can serve as a host molecule, using the chelation effect to selectively bind desired ions (such as Zn 2+, Co 2+, Ni 2+, Cu 2+) .
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- HY-B0300
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D-(-)-Penicillamine
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Cuproptosis
Drug Metabolite
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Inflammation/Immunology
Cancer
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Penicillamine (D-(-)-Penicillamine) is a penicillin metabolic degradation product, can be used as a heavy metal chelator. Penicillamine reduces free copper and reduces oxidative stress. Penicillamine has effect of seizures through nitric oxide/NMDA pathways. Penicillamine is a potential immune modulator. Penicillamine can be used for the research of Wilson disease, rheumatoid arthritis, and cystinuria .
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- HY-132927A
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Others
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Others
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Salpyran is a Cu(II) selective chelator with therapeutic potential .
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- HY-132927B
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Reactive Oxygen Species
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Inflammation/Immunology
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Salpyran dihydrochloride is a Cu(II) selective chelator with therapeutic potential. Salpyran dihydrochloride prevents the formation of reactive oxygen species from the binary Cu(II)/H2O2 system .
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- HY-W004544S
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1,10-Phenanthroline-d8
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Isotope-Labeled Compounds
MMP
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Others
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o-Phenanthroline-d8 is the deuterium labeled o-Phenanthroline. o-Phenanthroline (1,10-Phenanthroline), a metal chelator, prevents the induction of chromosomal aberrations in streptozotocin-treated cells. o-Phenanthroline (1,10-Phenanthroline) forms a red chelate with Fe2+ that absorbs maximally at 510 nm. o-Phenanthroline (1,10-Phenanthroline) is also a MMP inhibitor[1][2].
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- HY-144659
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Beta-lactamase
Apoptosis
Bacterial
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Infection
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Metallo-β-lactamase-IN-5 (compound 5c) is a potent metallo-β-lactamases (MBL) inhibitor. Metallo-β-lactamase-IN-5 shows inhibitory activity against MBLs NDM-1 and VIM-1. Metallo-β-lactamase-IN-5 inhibits HUVECs with an IC50 of 45 μg/mL. Metallo-β-lactamase-IN-5 plus Imipenem exhibits synergistic antimicrobial activity .
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- HY-B0988
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- HY-B1005
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8-Quinolinol
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Bacterial
Antibiotic
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Cancer
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8-Hydroxyquinoline (8-Quinolinol) is a lipophilic metal chelator that can be used as a fungicide .8-Hydroxyquinoline shows the MIC range of 27.56-55.11 μM (4-8 μg/mL) against the clinical isolates of Neisseria gonorrhoeae. 8-Hydroxyquinoline can bind to copper form complexes and transport copper into cells. 8-Hydroxyquinoline increases in the number of micronucleated polychromatic erythrocytes and can also make hair depigmented in mice .
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- HY-B1625
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- HY-115973
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Cholinesterase (ChE)
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Neurological Disease
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AChE-IN-11 (compound 5C) is a triple inhibitor targeting AChE/MAO-B/BACE1 (IC50=7.9 μM, 9.9 μM, 8.3 μM, respectively) and a selective metal ion chelators. AChE-IN-11 exhibits mixed AChE inhibitory effects, binding to both CAS and PAS of AChE. AChE-IN-11 also exhibits good antioxidant activity (ORAC=2.5 eq) and potential neuroprotective effects in Alzheimer's disease .
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- HY-149418
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HDAC
Cholinesterase (ChE)
Tau Protein
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Neurological Disease
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BChE/HDAC6-IN-2 (compound 29a) is a dual inhibitor of BChE and HDAC6 with IC50s of 1.8 nM and 71.0 nM, respectively. BChE/HDAC6-IN-2 has prominently neuroprotective effects and reactive oxygen species (ROS) scavenging activity. BChE/HDAC6-IN-2 is also an effective chelator of metal ion (Fe2+ and Cu2+). BChE/HDAC6-IN-2 inhibits phosphorylation of tau, and exhibits moderate immunomodulatory effect.
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- HY-144790
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Amyloid-β
Cholinesterase (ChE)
Monoamine Oxidase
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Neurological Disease
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AChE-IN-12 is a potent and blood-brain barrier (BBB) penetrant acetylcholinesterase (AChE) with IC50s of 0.41 μM and 1.88 μM for rat AChE and electric eel AChE. AChE-IN-12 is also a good antioxidant (ORAC = 3.3 eq), selective metal chelator and huMAO-B inhibitor (IC50 = 8.8 µM). AChE-IN-12 has remarkable inhibition of self- and Cu 2+-induced Aβ1-42 aggregation, as well as exhibits a good neuroprotective effect. AChE-IN-12 can be used for researching Alzheimer’s disease .
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- HY-146669
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Cholinesterase (ChE)
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Neurological Disease
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BChE-IN-6 (compound 12) is a potent BChE inhibitor, with a Ki of 0.182 μM. BChE-IN-6 shows chelating capacity on Zn 2+. BChE-IN-6 can be used for Alzheimer’s disease (AD) research .
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Cat. No. |
Product Name |
Type |
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- HY-D1746
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EDTA acetoxymethyl ester; Ethylenediaminetetraacetic acid acetoxymethyl ester
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Fluorescent Dyes/Probes
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EDTA-AM (ethylenediaminetetraacetic acid, acetoxymethyl ester) is the membrane-permeant form of the metal chelator EDTA (HY-Y0682). Live cells passively load EDTA-AM by incubating with EDTA-AM. Once internalized, cytoplasmic esterase decomposes AM esters, releasing the active ligand EDTA, which isolates metal ions within the cell. EDTA-AM induces an arrest of mitotic progression and chromosome decondensation .
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- HY-D1641
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Fluorescent Dyes/Probes
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5,5'-Dimethyl BAPTA tetrapotassium is a water-soluble, extracellular membrane metal chelator with relative selectivity for calcium ions .
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Cat. No. |
Product Name |
Type |
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- HY-45290
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Biochemical Assay Reagents
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trans-1,2-Cyclohexanediaminetetraacetic acid is a commonly used aminopolycarboxylic acid and a strong chelator of heavy metal ions .
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- HY-20512
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Biochemical Assay Reagents
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N,N'-Dibenzylethylenediamine forms chelator with metals. N,N'-Dibenzylethylenediamine interacts with penicillin, forms a stable and tasteless salt of penicillin .
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- HY-Y1841
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1,10-Phenanthroline monohydrate
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Biochemical Assay Reagents
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o-Phenanthroline (1,10-Phenanthroline) monohydrate, a metal chelator, prevents the induction of chromosomal aberrations in streptozotocin-treated cells. o-Phenanthroline monohydrate forms a red chelate with Fe 2+ that absorbs maximally at 510 nm. o-Phenanthroline (1,10-Phenanthroline) monohydrate is also a MMP inhibitor .
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- HY-W004544
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1,10-Phenanthroline
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Biochemical Assay Reagents
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o-Phenanthroline (1,10-Phenanthroline), a metal chelator, prevents the induction of chromosomal aberrations in streptozotocin-treated cells. o-Phenanthroline (1,10-Phenanthroline) forms a red chelate with Fe 2+ that absorbs maximally at 510 nm. o-Phenanthroline (1,10-Phenanthroline) is also a MMP inhibitor .
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- HY-W011060
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4,7,13,16,21,24-Hexaoxa-1,10-diazabicyclo[8.8.8]hexacosane
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Biochemical Assay Reagents
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Cryptand 2.2.2 is a metal ion chelator that can be used as a reducing agent and stabilizer to prepare nanoparticles. At room temperature, Cryptand 2.2.2 can serve as a host molecule, using the chelation effect to selectively bind desired ions (such as Zn 2+, Co 2+, Ni 2+, Cu 2+) .
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Cat. No. |
Product Name |
Target |
Research Area |
Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
Cat. No. |
Product Name |
Chemical Structure |
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- HY-Y0682S
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EDTA-d12 is the deuterium labeled Ethylenediaminetetraacetic acid[1]. Ethylenediaminetetraacetic acid (EDTA) is a metal chelators (binds to metal divalent and trivalent cations including calcium), which shows activities of anticoagulant and anti-hypercalcemic. Ethylenediaminetetraacetic acid decreases the metal ion-catalyzed oxidative damage to proteins, and allows maintenance of reducing environment during protein purification. Ethylenediaminetetraacetic acid can also decrease the formation of disulfide bonds[2][3][4].
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- HY-Y0682S1
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Ethylenediaminetetraacetic acid-d16 is the deuterium labeled Ethylenediaminetetraacetic acid[1]. Ethylenediaminetetraacetic acid (EDTA) is a metal chelators (binds to metal divalent and trivalent cations including calcium), which shows activities of anticoagulant and anti-hypercalcemic. Ethylenediaminetetraacetic acid decreases the metal ion-catalyzed oxidative damage to proteins, and allows maintenance of reducing environment during protein purification. Ethylenediaminetetraacetic acid can also decrease the formation of disulfide bonds[2][3][4].
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- HY-W004544S
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o-Phenanthroline-d8 is the deuterium labeled o-Phenanthroline. o-Phenanthroline (1,10-Phenanthroline), a metal chelator, prevents the induction of chromosomal aberrations in streptozotocin-treated cells. o-Phenanthroline (1,10-Phenanthroline) forms a red chelate with Fe2+ that absorbs maximally at 510 nm. o-Phenanthroline (1,10-Phenanthroline) is also a MMP inhibitor[1][2].
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