Search Result

Results for "

methyltransferase activity

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Amine N-methyltransferase (2) COMT (1) DNA Methyltransferase (9) Histone Methyltransferase (61) METTL3 (1) Adrenergic Receptor (6) Apoptosis (17) Autophagy (4) Bacterial (2) DNA/RNA Synthesis (3) Dopamine Receptor (5) Endogenous Metabolite (4) Fungal (1) GCGR (1) HDAC (5) Influenza Virus (3) Isotope-Labeled Compounds (3) Keap1-Nrf2 (1) N-myristoyltransferase (1) Nucleoside Antimetabolite/Analog (54) Orthopoxvirus (2) PROTACs (4) SARS-CoV (3) Sirtuin (2) VSV (2) WDR5 (9)
By Research Areas:	Cancer (108) Cardiovascular Disease (2) Endocrinology (6) Infection (12) Inflammation/Immunology (3) Metabolic Disease (2) Neurological Disease (9)
Click Chemistry:	Azide (3)
Oligonucleotides:	Nucleosides and their Analogs (35) Nucleoside Phosphoramidites (5)

145

Inhibitors & Agonists

Screening Libraries

Peptides

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Oligonucleotides

Targets Recommended: Histone Methyltransferase Amine N-methyltransferase DNA Methyltransferase COMT ICMT METTL3

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-147525

PROTAC EZH2 Degrader-1 1 Publications Verification	PROTACs Histone Methyltransferase	Cancer
PROTAC EZH2 Degrader-1 (Compound 150d), a potent PROTAC EZH2 Degrader, exerts inhibitory effect on EZH2 methyltransferase activity with the IC₅₀ of 2.7 nM. EZH2 plays an important role in many tumorigenesis and development processes .

HY-122936

Tanshindiol C	Histone Methyltransferase Keap1-Nrf2 Sirtuin	Cardiovascular Disease Cancer
Tanshindiol C is a S-adenosylmethionine-competitive EZH2 (Histone Methyltransferase) inhibitor with an IC₅₀ of 0.55 μM for inhibiting the methyltransferase activity. Tanshindiol C is also an activator of both Nrf2 and Sirtuin 1 (Sirt1) in macrophages. Tanshindiol C possesses anti-cancer activity, and can be used for atherosclerosis research .

HY-148458

EZH2-IN-14	Histone Methyltransferase	Cancer
EZH2-IN-14 is a selective EZH2 (Histone Methyltransferase) inhibitor with an IC₅₀ of 12 nM. EZH2-IN-14 inhibits the methyltransferase activity of EZH2/PRC2 (that is, reducing H3K27me3). EZH2-IN-14 shows >200-fold selective for EZH2 over the highly homologous H3K27 methyltransferase EZH1 .

HY-111213

PRMT5-IN-20	Histone Methyltransferase	Cancer
PRMT5-IN-20 is a selective protein arginine methyltransferase 5 (PRMT5) inhibitor with anti-tumor activity .

HY-A0004

Decitabine Maximum Cited Publications 111 Publications Verification 5-Aza-2'-deoxycytidine; 5-AZA-CdR; NSC 127716	DNA Methyltransferase Apoptosis Nucleoside Antimetabolite/Analog	Cancer
Decitabine (NSC 127716) is an orally active deoxycytidine analogue antimetabolite and a DNA methyltransferase inhibitor. Decitabine incorporates into DNA in place of cytosine can covalently trap DNA methyltransferase to DNA causing irreversible inhibition of the enzyme. Decitabine induces cell G2/M arrest and cell apoptosis. Decitabine has potent anticancer activity .

HY-100757

CPUY074020	Histone Methyltransferase	Cancer
CPUY074020 is a potent and oral bioavailable inhibitor of histone methyltransferase G9a, with an IC₅₀ of 2.18 μM. CPUY074020 possesses anti-proliferative activity .

HY-144188

PRMT5-IN-17	Histone Methyltransferase	Cancer
PRMT5-IN-17 (Compound 6) is a PRMT5 inhibitor with anti-tumor activity. PRMT5 is a type of protein arginine methyltransferase, and is a new anti-tumor target related to epigenetic modification .

HY-144187

PRMT5-IN-16	Histone Methyltransferase	Cancer
PRMT5-IN-16 (Compound 20) is a PRMT5 inhibitor with anti-tumor activity. PRMT5 is a type of protein arginine methyltransferase, and is a new anti-tumor target related to epigenetic modification .

HY-P3822

PRMT5-IN-23	Histone Methyltransferase	Cancer
PRMT5-IN-23 (compound 50) is an inhibitor of *protein arginine methyltransferase* 5 (PRMT5*) with anti-tumor activity. PRMT5* is a type of protein arginine methyltransferase, and is a new anti-tumor target related to epigenetic modification .

HY-122427

Xylocytidine	Nucleoside Antimetabolite/Analog	Cancer
Xylocytidine is a cytidine analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities .

HY-W400159

5-Methoxy cytidine	Nucleoside Antimetabolite/Analog	Cancer
5-Methoxy cytidine is a cytidine analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities .

HY-W578275

3′-O-Methylcytidine	Nucleoside Antimetabolite/Analog	Cancer
3′-O-Methylcytidine is a cytidine analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities .

HY-152694

5-Vinylcytidine	Nucleoside Antimetabolite/Analog	Others
5-Vinylcytidine is a cytidine nucleoside analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities .

HY-152658

5-Phenylcytidine	Nucleoside Antimetabolite/Analog	Others
5-Phenylcytidine is a cytidine nucleoside analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities .

HY-W555551

5-Ethyl cytidine	Nucleoside Antimetabolite/Analog	Cancer
5-Ethyl cytidine is a cytidine analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities .

HY-A0004R

Decitabine (Standard) 5-Aza-2'-deoxycytidine (Standard); 5-AZA-CdR (Standard); NSC 127716 (Standard)	DNA Methyltransferase Apoptosis Nucleoside Antimetabolite/Analog	Cancer
Decitabine (Standard) is the analytical standard of Decitabine. This product is intended for research and analytical applications. Decitabine (NSC 127716) is an orally active deoxycytidine analogue antimetabolite and a DNA methyltransferase inhibitor. Decitabine incorporates into DNA in place of cytosine can covalently trap DNA methyltransferase to DNA causing irreversible inhibition of the enzyme. Decitabine induces cell G2/M arrest and cell apoptosis. Decitabine has potent anticancer activity .

HY-134828

AZ506 2 Publications Verification	Histone Methyltransferase	Cancer
AZ506 is a potent SMYD2 inhibitor with an IC₅₀ of 17 nM. AZ506 inhibits SMYD2 methyltransferase activity in cells, leading to a decrease in the SMYD2-mediated methylation signal .

HY-154699

5-(2-Hydroxyethyl)cytidine	Nucleoside Antimetabolite/Analog	Cancer
5-(2-Hydroxyethyl)cytidine is a cytidine analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities .

HY-116971

DCG066	Histone Methyltransferase Apoptosis	Cancer
DCG066 is an inhibitor of *lysine methyltransferase* G9a*. DCG066 can bind directly to G9a and inhibit methyltransferase* activity in vitro. DCG066 decreases di-methylation levels of histone H3 lysine 9 (H3K9Me2), inhibits cell proliferation and induces cell apoptosis. DCG066 displays low cytotoxicity in leukemia cell lines with high levels of G9a expression, including K562 .

HY-152784

5’(R)-C-Methylcytidine	Nucleoside Antimetabolite/Analog	Others
5’(R)-C-Methylcytidine is a cytidine nucleoside analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities .

HY-152394

3’-beta-C-Methylcytidine	Nucleoside Antimetabolite/Analog	Others
3’-beta-C-Methylcytidine is a cytidine nucleoside analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities .

HY-152446

N4-Methylarabinocytidine	Nucleoside Antimetabolite/Analog	Others
N4-Methylarabinocytidine is a cytidine nucleoside analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities .

HY-154150

N-(1-Oxopropyl)cytidine	Nucleoside Antimetabolite/Analog	Cancer
N-(1-Oxopropyl)cytidine is a cytidine analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities .

HY-107777

LLY-283 3 Publications Verification	Histone Methyltransferase	Cancer
LLY-283 is a potent, selective and oral protein arginine methyltransferase 5 (PRMT5) inhibitor, with an IC₅₀ of 22 nM and a K_d of 6 nM for PRMT5:MEP50 complex, and shows antitumor activity.

HY-101564

Onametostat 5+ Cited Publications JNJ-64619178	Histone Methyltransferase	Cancer
Onametostat (JNJ-64619178) is a selective, orally active and pseudo-irreversible *protein arginine methyltransferase* 5 (PRMT5) inhibitor with an IC₅₀** of 0.14 nM. Onametostat has potent activity in lung cancer .

HY-164497

NSC 641396	DNA/RNA Synthesis Histone Methyltransferase	Cancer
NSC 641396 is a ribonucleotide reductase (RNR) inhibitor with an IC₅₀ value of 1.2 μM. NSC 641396 is also a protein arginine N-methyltransferase 9 (PRMT9) inhibitor. NSC 641396 has antitumor activity .

HY-W115186

DMT-2'-OMe-Bz-C	Nucleoside Antimetabolite/Analog	Cancer
DMT-2'-OMe-Bz-C is a cytidine analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities .

HY-154413

DMT-2'-F-Bz-dC	Nucleoside Antimetabolite/Analog	Cancer
DMT-2'-F-Bz-dC is a cytidine analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities .

HY-W009538

5-Fluoro-5'-deoxycytidine	Nucleoside Antimetabolite/Analog	Cancer
5-Fluoro-5'-deoxycytidine is a cytidine analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities .

HY-A0004S

Decitabine-13C5 5-Aza-2'-deoxycytidine-¹³C₅; 5-AZA-CdR-¹³C₅; NSC 127716-¹³C₅	Isotope-Labeled Compounds DNA Methyltransferase Nucleoside Antimetabolite/Analog Apoptosis	Cancer
Decitabine- ¹³C₅ (5-Aza-2'-deoxycytidine- ¹³C₅) is ¹³C labeled Decitabine. Decitabine (NSC 127716) is an orally active deoxycytidine analogue antimetabolite and a DNA methyltransferase inhibitor. Decitabine incorporates into DNA in place of cytosine can covalently trap DNA methyltransferase to DNA causing irreversible inhibition of the enzyme. Decitabine induces cell G2/M arrest and cell apoptosis. Decitabine has potent anticancer activity .

HY-W130466

N4-Methylcytidine	Nucleoside Antimetabolite/Analog	Others Cancer
N4-Methylcytidine (Nsc518744) is a cytidine nucleoside analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities .

HY-152382

3’-O-(2-Methoxyethyl)cytidine	Nucleoside Antimetabolite/Analog	Cancer
3’-O-(2-Methoxyethyl)cytidine is a cytidine analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities .

HY-15647

BRD9539 1 Publications Verification	Histone Methyltransferase	Cancer
BRD9539 is a *histone methyltransferase* G9a inhibitor with an IC₅₀ of 6.3 μM. BRD9539 also inhibits PRC2** activity and is inactive against SUV39H1, NSD2 and DNMT1 .

HY-101904

2-Chloro-2'-deoxycytidine	Nucleoside Antimetabolite/Analog	Others
2-Chloro-2'-deoxycytidine is a cytidine nucleoside analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities .

HY-E70345

Homocysteine methyltransferase	Endogenous Metabolite	Others
Homocysteine methyltransferase is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible .

HY-N2150

Psammaplin A	HDAC DNA Methyltransferase DNA/RNA Synthesis Bacterial	Infection Cancer
Psammaplin A, a marine metabolite, is a potent inhibitor of HDAC and DNA methyltransferases. Psammaplin A ia a highly potent and selective DAC1 inhibitor with an IC₅₀ of 0.9 nM. Psammaplin A possess the antimicrobial effect on the Gram-positive bacteria and inhibits DNA synthesis and DNA gyrase activity. Antitumor Activity .

HY-10442

3-Deazaneplanocin A 25+ Cited Publications DZNep; 3-Deazaneplanocin	Histone Methyltransferase Orthopoxvirus	Infection Cancer
3-Deazaneplanocin A (DZNep) is a potent *histone methyltransferase* EZH2 inhibitor . 3-Deazaneplanocin A is a potent S-adenosylhomocysteine hydrolase (AHCY)** inhibitor. 3-Deazaneplanocin A shows anti-orthopoxvirus activity .

HY-152360

1-(β-D-Xylofuranosyl)-5-methylcytosine	Nucleoside Antimetabolite/Analog	Cancer
1-(β-D-Xylofuranosyl)-5-methylcytosine is a cytidine analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities .

HY-152528

4’-C-Methyl-5-methylcytidine	Nucleoside Antimetabolite/Analog	Others
4’-C-Methyl-5-methylcytidine is a cytidine nucleoside analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities .

HY-154151

N4-(3,3,3-Trifluoropropanoyl)cytidine	Nucleoside Antimetabolite/Analog	Cancer
N4-(3,3,3-Trifluoropropanoyl)cytidine is a cytidine analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities .

HY-152714

5-Formyl-2’-O-methylcytidine	Nucleoside Antimetabolite/Analog	Others
5-Formyl-2’-O-methylcytidine is a cytidine nucleoside analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities .

HY-152406

3’-Beta-C-Methyl-5-methylcytidine	Nucleoside Antimetabolite/Analog	Cancer
3’-Beta-C-Methyl-5-methylcytidine is a cytidine analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities .

HY-152822

5-Iodo-2’-O-methylcytidine	Nucleoside Antimetabolite/Analog	Others
5-Iodo-2’-O-methylcytidine is a cytidine nucleoside analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities .

HY-152526

5-Fluoro-4’-C-methylcytidine	Nucleoside Antimetabolite/Analog	Others
5-Fluoro-4’-C-methylcytidine is a cytidine nucleoside analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities .

HY-12310

RSC133	DNA Methyltransferase HDAC	Others
RSC133 exhibits dual activity by inhibiting histone deacetylase and DNA methyltransferase. RSC133 effectively facilitates reprogramming of human somatic cells to pluripotent stem cells and supports the maintenance of an undifferentiated state of human pluripotent stem cells .

HY-E70349

Betaine homocysteine S-methyltransferase	Endogenous Metabolite	Others
Betaine homocysteine S-methyltransferase is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible .

HY-152483

N4,N4-Dimethylarabinocytidine	Nucleoside Antimetabolite/Analog	Others
N4,N4-Dimethylarabinocytidine is a cytidine nucleoside analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities .

HY-W114787

N4-Benzoyl-2’-O-methylcytidine	Nucleoside Antimetabolite/Analog	Cancer
N4-Benzoyl-2’-O-methylcytidine is a cytidine analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities .

HY-113786

EZH2-IN-21	Histone Methyltransferase	Cancer
EZH2-IN-21 is a potent inhibitor of the histone lysine methyltransferase enhancer of zeste homologue 2 (EZH2) with anticancer activity. EZH2-IN-21 is competitive with the cofactor SAM and noncompetitive with peptide or nucleosome substrates .

HY-152300

N4,N4-Dimethylcytidine	Nucleoside Antimetabolite/Analog	Others
N4,N4-Dimethylcytidine is a cytidine nucleoside analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities .

Cat. No.	Product Name

HY-L005

Epigenetics Compound Library

1,546 compounds

Epigenetics refers to changes in phenotype that are not rooted in DNA sequence. Many types of epigenetic processes have been identified, including DNA methylation, alteration in the structure of histone proteins and gene regulation by small noncoding microRNAs. Modification of DNA, protein, or RNA, resulting in changes to the function and/or regulation of these molecules, without altering their primary sequences, reveals the complexities of cellular differentiation, embryology, the regulation of gene expression, aging, cancer, and other diseases.

MCE provide a unique collection of 1,546 epigenetics-related compounds that can be used in the research of the related diseases.

Cat. No.	Product Name	Target	Research Area

HY-P3822

PRMT5-IN-23	Histone Methyltransferase	Cancer
PRMT5-IN-23 (compound 50) is an inhibitor of *protein arginine methyltransferase* 5 (PRMT5*) with anti-tumor activity. PRMT5* is a type of protein arginine methyltransferase, and is a new anti-tumor target related to epigenetic modification .

HY-P5416

GGASCCLYCRCH	Peptides	Others
GGASCCLYCRCH is a biological active peptide. (can inhibit the 2-O-methyltransferase activity of the SARS-CoV complex nsp16/10)

HY-P4727

(β-Asp5)-Delta-Sleep Inducing Peptide DSIP-isoD	Peptides	Others
(β-Asp5)-Delta-Sleep Inducing Peptide (DSIP-isoD) is a synthetic polypeptide that can be partially hydrolyzed by NaOH or SDS. (β-Asp5)-Delta-Sleep Inducing Peptide can be used to study the catalytic activity of mitochondrial protein L-isoaspartyl (D-aspartyl) methyltransferase (PIMT) .

HY-19554

MM-401	WDR5 Apoptosis	Cancer
MM-401 is a MLL1 H3K4 methyltransferase inhibitor. MM-401 inhibits MLL1 activity (IC₅₀ = 0.32 μM) by blocking MLL1-WDR5 interaction. MM-401 can induce cell cycle arrest, apoptosis and differentiation. MM-401 can be used for the research of MLL leukemia .

HY-P10570

[Nle20] H4 peptide (16−23)	Histone Methyltransferase	Cancer
[Nle20] H4 peptide (16−23) is a peptide with strong inhibitory activity against histone methyltransferase SETD8 (K_d=0.14 μM), which inhibits SETD8's methylation of histone H4 by competing with SETD8's substrate binding site. [Nle20] H4 peptide (16−23) can be used as a lead compound for anticancer therapy .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-122936

Tanshindiol C	Structural Classification Terpenoids Labiatae Samanea saman (Jacq.) Merr. Diterpenoids Plants	Histone Methyltransferase Keap1-Nrf2 Sirtuin
Tanshindiol C is a S-adenosylmethionine-competitive EZH2 (Histone Methyltransferase) inhibitor with an IC₅₀ of 0.55 μM for inhibiting the methyltransferase activity. Tanshindiol C is also an activator of both Nrf2 and Sirtuin 1 (Sirt1) in macrophages. Tanshindiol C possesses anti-cancer activity, and can be used for atherosclerosis research .

HY-N2150

Psammaplin A	Structural Classification Classification of Application Fields Marine natural products Source classification Antibacterial Disease Research Other Antibiotics Infection Microorganisms Animals Antibiotics Phenols Polyphenols Sponge Anticancer Disease Research Fields	HDAC DNA Methyltransferase DNA/RNA Synthesis Bacterial
Psammaplin A, a marine metabolite, is a potent inhibitor of HDAC and DNA methyltransferases. Psammaplin A ia a highly potent and selective DAC1 inhibitor with an IC₅₀ of 0.9 nM. Psammaplin A possess the antimicrobial effect on the Gram-positive bacteria and inhibits DNA synthesis and DNA gyrase activity. Antitumor Activity .

HY-B2194

γ-Oryzanol 5+ Cited Publications	Structural Classification Monophenols other families Classification of Application Fields Source classification Phenols Plants Disease Research Fields Steroids Cancer	DNA Methyltransferase
γ-Oryzanol is a potent DNA methyltransferases (DNMTs) inhibitor in the striatum of mice. γ-Oryzanol significantly inhibits the activities of DNMT1 (IC₅₀=3.2 μM), DNMT3a (IC₅₀=22.3 μM).

HY-N0086R

N6-Methyladenosine (Standard)	Structural Classification Natural Products Microorganisms Source classification Endogenous metabolite	Influenza Virus Endogenous Metabolite
N6-Methyladenosine (Standard) is the analytical standard of N6-Methyladenosine. This product is intended for research and analytical applications. N6-Methyladenosine is the most prevalent internal (non-cap) modification present in the messenger RNA (mRNA) of all higher eukaryotes. N6-Methyladenosine can modifies viral RNAs and has antiviral activities. In Vitro: N6-methyladenosine (m6A) is selectively recognized by the human YTH domain family 2 (YTHDF2) protein to regulate mRNA degradation. N6-methyladenosine (m6A), a prevalent internal modification in the messenger RNA of all eukaryotes, is post-transcriptionally installed by m6A methyltransferase (e.g., MT-A70) within the consensus sequence of G(m6A)C (70%) or A(m6A)C (30%). N6-methyladenosine (m6A)-containing RNAs are greatly enriched in the YTHDF-bound portion and diminished in the flow-through portion . N6-methyladenosine (m6A), the most abundant internal RNA modification, functions in diverse biological processes, including regulation of embryonic stem cell self-renewal and differentiation. N6-methyladenosine (m6A) is a large protein complex, consisting in part of methyltransferase-like 3 (METTL3) and methyltransferase-like 14 (METTL14) catalytic subunits .

Cat. No.	Product Name	Chemical Structure

HY-A0004S

Decitabine-13C5

Decitabine- ¹³C₅ (5-Aza-2'-deoxycytidine- ¹³C₅) is ¹³C labeled Decitabine. Decitabine (NSC 127716) is an orally active deoxycytidine analogue antimetabolite and a DNA methyltransferase inhibitor. Decitabine incorporates into DNA in place of cytosine can covalently trap DNA methyltransferase to DNA causing irreversible inhibition of the enzyme. Decitabine induces cell G2/M arrest and cell apoptosis. Decitabine has potent anticancer activity .

HY-W009538S

5-Fluoro-5'-deoxycytidine-d3
5-Fluoro-5'-deoxycytidine-d₃ is deuterated labeled 5-Fluoro-5'-deoxycytidine (HY-W009538). 5-Fluoro-5'-deoxycytidine is a cytidine analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities .

HY-W009538S1

5-Fluoro-5'-deoxycytidine-13C5
5-Fluoro-5'-deoxycytidine-13C5 is the ¹³C labeled isotope of 5-Fluoro-5'-deoxycytidine (HY-W009538). 5-Fluoro-5'-deoxycytidine is a cytidine analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities .

Cat. No.	Product Name		Classification

HY-152789

5-(2-Azidoethyl)cytidine		Azide
5-(2-Azidoethyl)cytidine is a cytidine nucleoside analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities . 5-(2-Azidoethyl)cytidine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-152787

5-(3-Azidopropyl)cytidine		Azide
5-(3-Azidopropyl)cytidine is a cytidine nucleoside analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities . 5-(3-Azidopropyl)cytidine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-152310

N4-(n-Palmitoyl)-4’-azido-2’-deoxy-2’-fluoro-arabinocytidine		Azide
N4-(n-Palmitoyl)-4’-azido-2’-deoxy-2’-fluoro-arabinocytidine is a cytidine nucleoside analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities . N4-(n-Palmitoyl)-4’-azido-2’-deoxy-2’-fluoro-arabinocytidine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

Cat. No.	Product Name		Classification

HY-W578275

3′-O-Methylcytidine		Nucleosides and their Analogs
3′-O-Methylcytidine is a cytidine analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities .

HY-152694

5-Vinylcytidine		Nucleosides and their Analogs
5-Vinylcytidine is a cytidine nucleoside analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities .

HY-152658

5-Phenylcytidine		Nucleosides and their Analogs
5-Phenylcytidine is a cytidine nucleoside analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities .

HY-W555551

5-Ethyl cytidine		Nucleosides and their Analogs
5-Ethyl cytidine is a cytidine analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities .

HY-154699

5-(2-Hydroxyethyl)cytidine		Nucleosides and their Analogs
5-(2-Hydroxyethyl)cytidine is a cytidine analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities .

HY-152784

5’(R)-C-Methylcytidine		Nucleosides and their Analogs
5’(R)-C-Methylcytidine is a cytidine nucleoside analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities .

HY-152394

3’-beta-C-Methylcytidine		Nucleosides and their Analogs
3’-beta-C-Methylcytidine is a cytidine nucleoside analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities .

HY-152446

N4-Methylarabinocytidine		Nucleosides and their Analogs
N4-Methylarabinocytidine is a cytidine nucleoside analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities .

HY-154150

N-(1-Oxopropyl)cytidine		Nucleosides and their Analogs
N-(1-Oxopropyl)cytidine is a cytidine analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities .

HY-154413

DMT-2'-F-Bz-dC		Nucleosides and their Analogs
DMT-2'-F-Bz-dC is a cytidine analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities .

HY-152382

3’-O-(2-Methoxyethyl)cytidine		Nucleosides and their Analogs
3’-O-(2-Methoxyethyl)cytidine is a cytidine analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities .

HY-152360

1-(β-D-Xylofuranosyl)-5-methylcytosine		Nucleosides and their Analogs
1-(β-D-Xylofuranosyl)-5-methylcytosine is a cytidine analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities .

HY-152528

4’-C-Methyl-5-methylcytidine		Nucleosides and their Analogs
4’-C-Methyl-5-methylcytidine is a cytidine nucleoside analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities .

HY-154151

N4-(3,3,3-Trifluoropropanoyl)cytidine		Nucleosides and their Analogs
N4-(3,3,3-Trifluoropropanoyl)cytidine is a cytidine analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities .

HY-152714

5-Formyl-2’-O-methylcytidine		Nucleosides and their Analogs
5-Formyl-2’-O-methylcytidine is a cytidine nucleoside analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities .

HY-152406

3’-Beta-C-Methyl-5-methylcytidine		Nucleosides and their Analogs
3’-Beta-C-Methyl-5-methylcytidine is a cytidine analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities .

HY-152822

5-Iodo-2’-O-methylcytidine		Nucleosides and their Analogs
5-Iodo-2’-O-methylcytidine is a cytidine nucleoside analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities .

HY-152526

5-Fluoro-4’-C-methylcytidine		Nucleosides and their Analogs
5-Fluoro-4’-C-methylcytidine is a cytidine nucleoside analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities .

HY-152483

N4,N4-Dimethylarabinocytidine		Nucleosides and their Analogs
N4,N4-Dimethylarabinocytidine is a cytidine nucleoside analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities .

HY-152300

N4,N4-Dimethylcytidine		Nucleosides and their Analogs
N4,N4-Dimethylcytidine is a cytidine nucleoside analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities .

HY-154480

N4-Benzoyl-3’-O-methylcytidine		Nucleosides and their Analogs
N4-Benzoyl-3’-O-methylcytidine is a cytidine analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities .

HY-152480

3’-O-(2-Methoxyethyl)-5-methylcytidine		Nucleosides and their Analogs
3’-O-(2-Methoxyethyl)-5-methylcytidine is a cytidine analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities .

HY-154397

2',3',5'-Tri-O-benzoyl-5-azacytidine		Nucleosides and their Analogs
2',3',5'-Tri-O-benzoyl-5-azacytidine is a cytidine analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities .

HY-W128788A

2’-Deoxy-2’-fluoro-b-D-arabinocytidine hydrochloride		Nucleosides and their Analogs
2’-Deoxy-2’-fluoro-b-D-arabinocytidine(hydrochloride) is a cytidine nucleoside analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities .

HY-104039

2'-Deoxy-5'-O-DMT-5-methylcytidine		Nucleoside Phosphoramidites
2'-Deoxy-5'-O-DMT-5-methylcytidine is a cytidine analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities .

HY-152763

2’-Deoxy-2’-fluoro-5-methylcytidine		Nucleosides and their Analogs
2’-Deoxy-2’-fluoro-5-methylcytidine is a cytidine nucleoside analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities .

HY-152811

2′-Deoxy-2′-fluoro-5-methyl-arabinocytidine		Nucleosides and their Analogs
2′-Deoxy-2′-fluoro-5-methyl-arabinocytidine is a cytidine nucleoside analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities .

HY-154414

2’-Fluoro-2’-deoxy-ara-C(Bz)-3’-phosphoramidite		Nucleosides and their Analogs
2’-Fluoro-2’-deoxy-ara-C(Bz)-3’-phosphoramidite is a cytidine analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities .

HY-154019

N4-Benzoyl-5'-O-DMT-5-methylcytidine		Nucleoside Phosphoramidites
N4-Benzoyl-5'-O-DMT-5-methylcytidine is a cytidine analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities .

HY-152705

5-Bromo-2’-deoxy-2’-fluoro-beta-D-arabinocytidine		Nucleosides and their Analogs
5-Bromo-2’-deoxy-2’-fluoro-beta-D-arabinocytidine is a cytidine nucleoside analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities .

HY-152976

N4-Benzoyl-7’-O-(4,4’-dimethoxytrityloxy)morpholinocytosine		Nucleoside Phosphoramidites
N4-Benzoyl-7’-O-(4,4’-dimethoxytrityl oxy)morpholinocytosine is a cytidine analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities .

HY-152978

2'-Deoxy-5'-O-DMT-N4-Fmoc-5-methylcytidine		Nucleoside Phosphoramidites
2'-Deoxy-5'-O-DMT-N4-Fmoc-5-methylcytidine is a cytidine analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities .

HY-154000

3,5’-Bis(O-t-butyldimethylsilyl)-2’-O-methyl-5-methyl cytidine		Nucleosides and their Analogs
3,5’-Bis(O-t-butyldimethylsilyl)-2’-O-methyl-5-methyl cytidine is a cytidine analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities .

HY-154077

N4-Benzoyl-5-methyl-2’-O,4’-C-methylenecytidine		Nucleosides and their Analogs
N4-Benzoyl-5-methyl-2’-O,4’-C-methylenecytidine is a cytidine analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities .

HY-154450

N4-Benzoyl-5’-O-DMT-3’-O-(2-methoxyethyl)-5-methylcytidine		Nucleosides and their Analogs
N4-Benzoyl-5’-O-DMT-3’-O-(2-methoxyethyl)-5-methylcytidine is a cytidine analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities .

HY-152979

2'-Deoxy-5'-O-DMT-N4-Fmoc-5-methylcytidine 3'-CE-phosphoramidite		Nucleoside Phosphoramidites
2'-Deoxy-5'-O-DMT-N4-Fmoc-5-methylcytidine 3'-CE-phosphoramidite is a cytidine analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities .

HY-154441

N4-Benzoyl-3'-O-DMT-2'-O-(2-methoxyethyl)-5-methylcytidine		Nucleosides and their Analogs
N4-Benzoyl-3'-O-DMT-2'-O-(2-methoxyethyl)-5-methylcytidine is a cytidine analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities .