1. Gene
  2. SUB1 - SUB1 regulator of transcription Gene

SUB1 - SUB1 regulator of transcription Gene

Homo sapiens

Also known as P15; PC4; p14

Gene ID: 10923 | Gene type: protein coding

About SUB1

Cytogenetic location: 5p13.3 Genomic coordinates (GRCh38): 5:32,585,557-32,604,079 (from NCBI)

This gene has 13 transcripts (splice variants) and 228 orthologues. Ubiquitous expression in brain (RPKM 41.5), fat (RPKM 34.4) and 25 other tissues.

Summary

Enables identical protein binding activity; single-stranded DNA binding activity; and transcription coactivator activity. Involved in negative regulation of DNA metabolic process and regulation of transcription by RNA polymerase II. Located in nucleolus and nucleoplasm. Part of transcription regulator complex. [provided by Alliance of Genome Resources, Apr 2022]

SUB1 Products(1)

mRNA Protein Name
NM_006713.4 NP_006704.3 activated RNA polymerase II transcriptional coactivator p15
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
16415882 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
9847329 GOA
enables single-stranded DNA binding IDA
IDA: Inferred from direct assay
8062391 GOA
enables transcription coactivator activity IDA
IDA: Inferred from direct assay
8062391 GOA
Biological Process GO Annotation Evidence Reference Source
involved in RNA polymerase II promoter clearance IDA
IDA: Inferred from direct assay
25308091 GOA
involved in negative regulation of DNA duplex unwinding IDA
IDA: Inferred from direct assay
16605275 GOA
involved in negative regulation of DNA metabolic process IDA
IDA: Inferred from direct assay
28369605 GOA
involved in regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
8062391 GOA
Cellular Component GO Annotation Evidence Reference Source
part of transcription regulator complex IDA
IDA: Inferred from direct assay
8062391 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SUB1 Protein Structure

PC4

PC4: Transcriptional Coactivator p15 (PC4) (63 - 116)

  • 0
  • 100
  • 127 a.a.
Protein Preferred Names Protein Names

activated RNA polymerase II transcriptional coactivator p15

SUB1 homolog, transcriptional regulator

SUB1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
SUB1 P53999 CSTF2 Homo sapiens P33240-1 11389848
Intra
SUB1 P53999 SUB1 Homo sapiens P53999 16415882
Intra
SUB1 P53999 SUB1 Homo sapiens P53999 32296183
Intra
SUB1 P53999 SUB1 Homo sapiens P53999 25416956
Intra
SUB1 P53999 SUB1 Homo sapiens P53999 32296183
Intra
SUB1 P53999 SUB1 Homo sapiens P53999 32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SUB1 Proteins

Cat. No. Product Name Accession Purity
HY-P74650 PC4/SUB1 Protein, Human (His) P53999 (M1-L127) ≥95%

Related Diseases

Diseases Alias
Dyskeratosis Congenita, Autosomal Recessive 5

Dyskeratosis Congenita, Autosomal Dominant, 4

DKCB5

Autosomal Dominant Dyskeratosis Congenita 4

DKCA4

Autosomal Recessive Dyskeratosis Congenita 5

Dyskeratosis Congenita, Autosomal Recessive, 5

Dyskeratosis Congenita, Autosomal Dominant 4

Dyskeratosis Congenita, Autosomal Recessive, Type 5

Tinea Manuum

Tinea Manus

Dermatophytosis Of Hand

Cri-Du-Chat Syndrome

5p Deletion Syndrome

5p Partial Monosomy Syndrome

Monosomy 5p

Cat Cry Syndrome

Chromosome 5p Deletion Syndrome

Cri Du Chat Syndrome

5p- Syndrome

5p Minus Syndrome

Chromosome 5p- Syndrome

Chromosome 5 Short Arm Deletion Syndrome

Chromosome 5p Deletion

Deletion 5p

Cri Du Chat

5p Partial Deletion Syndrome

Partial Deletion Of Short Arm Of Chromosome 5 Syndrome

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Mus musculus SUB1 MGD MGI:104811
Rattus norvegicus SUB1 RGD RGD:621582
Bos taurus SUB1 VGNC VGNC:35454
Macaca mulatta SUB1 VGNC VGNC:110431
Others SUB1 NCBI