2. Gene
  3. Cdk4 - cyclin-dependent kinase 4 Gene

Cdk4 - cyclin-dependent kinase 4 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Crk3

Gene ID: 12567 | Gene type: protein coding

About Cdk4

Chromosome 10: 126,899,403-126,903,789 forward strand.GRCm39:CM001003.3

This gene has 9 transcripts (splice variants), 229 orthologues, 25 paralogues and is associated with 63 phenotypes. Broad expression in CNS E11.5 (RPKM 315.3), limb E14.5 (RPKM 224.3) and 25 other tissues.

Summary

Enables cyclin binding activity and cyclin-dependent protein serine/threonine kinase activity. Acts upstream of or within several processes, including cellular response to interleukin-4; cellular response to lipid; and regulation of lipid metabolic process. Located in bicellular tight junction; cytoplasm; and nucleus. Part of cyclin D2-CDK4 complex and transcription regulator complex. Is expressed in several structures, including alimentary system; branchial arch; genitourinary system; nervous system; and sensory organ. Used to study type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); familial melanoma; glioblastoma; obesity; and type 2 diabetes mellitus. Orthologous to human CDK4 (cyclin dependent kinase 4). [provided by Alliance of Genome Resources, Apr 2022]

Cdk4 Products(2)

mRNA Protein Name
NM_009870.4 NP_034000.1 cyclin-dependent kinase 4 isoform 1
NM_001355005.1 NP_001341934.1 cyclin-dependent kinase 4 isoform 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables cyclin binding IPI
IPI: Inferred from physical interaction
23109711 MGI
enables cyclin-dependent protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
12970171 MGI
enables kinase activity IDA
IDA: Inferred from direct assay
12124778 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
8033213 MGI
enables protein kinase activity IDA
IDA: Inferred from direct assay
12130539 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within cellular response to interleukin-4 IDA
IDA: Inferred from direct assay
8543804 MGI
acts upstream of or within cellular response to ionomycin IDA
IDA: Inferred from direct assay
8543804 MGI
acts upstream of or within cellular response to lipopolysaccharide IDA
IDA: Inferred from direct assay
8543804 MGI
acts upstream of or within cellular response to phorbol 13-acetate 12-myristate IDA
IDA: Inferred from direct assay
8543804 MGI
acts upstream of or within protein phosphorylation IDA
IDA: Inferred from direct assay
12124778 MGI
acts upstream of or within regulation of cell cycle IDA
IDA: Inferred from direct assay
12588994 MGI
acts upstream of or within regulation of type B pancreatic cell proliferation IMP
IMP: Inferred from mutant phenotype
12917627 MGI
acts upstream of or within signal transduction IDA
IDA: Inferred from direct assay
12130539 MGI
Cellular Component GO Annotation Evidence Reference Source
located in bicellular tight junction IDA
IDA: Inferred from direct assay
21411630 MGI
part of cyclin D1-CDK4 complex IPI
IPI: Inferred from physical interaction
17948060 MGI
part of cyclin D2-CDK4 complex IDA
IDA: Inferred from direct assay
7739547 MGI
part of cyclin-dependent protein kinase holoenzyme complex IPI
IPI: Inferred from physical interaction
12970760 MGI
located in nucleus IDA
IDA: Inferred from direct assay
8988060 MGI
part of transcription regulator complex IDA
IDA: Inferred from direct assay
10082561 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Cdk4 Protein Structure

STKc_CDK4

STKc_CDK4: cd07863 (4 - 294)

  • 0
  • 100
  • 200
  • 303 a.a.
Protein Preferred Names Protein Names

cyclin-dependent kinase 4

PSK-J3

cell division protein kinase 4

p34/cdk4

serine/threonine kinase

Related Agents

Approval
Bioactive Molecules (14)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-50767 Palbociclib Inhibitor 99.94% Unkown
HY-16297A Abemaciclib Inhibitor 99.97% Yes
HY-15777 Ribociclib Inhibitor 99.94% Unkown
HY-50767A Palbociclib monohydrochloride Inhibitor 99.98% Unkown
HY-16297 Abemaciclib methanesulfonate Inhibitor 99.95% Yes
HY-A0065 Palbociclib isethionate Inhibitor 99.99% Unkown
HY-50767C Palbociclib hydrochloride Inhibitor 99.93% Unkown
HY-15777A Ribociclib hydrochloride Inhibitor 99.95% Unkown
HY-15777B Ribociclib succinate Inhibitor 99.93% Unkown
HY-101467A Trilaciclib hydrochloride Inhibitor 99.69% Unkown
HY-114338 Dalpiciclib Inhibitor 99.40% Unkown
HY-15777C Ribociclib succinate hydrate Inhibitor 99.96% Unkown
HY-50767D Palbociclib orotate Inhibitor / Unkown
HY-50767B Palbociclib dihydrochloride Inhibitor / Unkown
Clinical Phase
Bioactive Molecules (27)
Cat. No. Product Name Effect
Purity Phase
HY-10580 GSK 3 Inhibitor IX Inhibitor 99.74% Phase 4
HY-139450 Atirmociclib Inhibitor 99.87% Phase 3
HY-114338A Dalpiciclib hydrochloride Inhibitor 98.22% Phase 3
HY-112272 Lerociclib Inhibitor 98.35% Phase 3
HY-10005 Flavopiridol Inhibitor 99.73% Phase 2
HY-101563 GSK3326595 99.97% Phase 2
HY-103712A Samuraciclib hydrochloride Inhibitor 99.98% Phase 2
HY-50940 AT7519 Inhibitor 99.76% Phase 2
HY-10006 Flavopiridol Hydrochloride Inhibitor 99.73% Phase 2
HY-13914 Roniciclib Inhibitor 98.09% Phase 2
HY-10424 Milciclib Inhibitor 99.90% Phase 2
HY-112272A Lerociclib dihydrochloride Inhibitor 98.11% Phase 2
HY-103712B Samuraciclib hydrochloride dihydrate Inhibitor 99.08% Phase 2
HY-50943 AT7519 Hydrochloride Inhibitor 99.42% Phase 2
HY-50940A AT7519 TFA Inhibitor 98.53% Phase 2
HY-103712 Samuraciclib Inhibitor / Phase 2
HY-16559A Riviciclib Inhibitor / Phase 2
HY-10008 SNS-032 Inhibitor 99.54% Phase 1
HY-10012 AZD-5438 Inhibitor 99.85% Phase 1
HY-10014 R547 Inhibitor 99.57% Phase 1
HY-12624 Narazaciclib Inhibitor 99.12% Phase 1
HY-11001 PHA-793887 Inhibitor 99.25% Phase 1
HY-111361 FN-1501 Inhibitor 99.08% Phase 1
HY-15504 RGB-286638 Inhibitor 99.70% Phase 1
HY-12422 Voruciclib Inhibitor 99.77% Phase 1
HY-15504A RGB-286638 free base Inhibitor 98.07% Phase 1
HY-12422A Voruciclib hydrochloride Inhibitor 99.23% Phase 1
Pre-clinical Phase
Bioactive Molecules (91)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-103248 Toyocamycin Inhibitor 99.90% Unkown
HY-10329 JNJ-7706621 Inhibitor 99.91% Unkown
HY-15339 CVT-313 Inhibitor 99.90% Unkown
HY-11009 CGP60474 Inhibitor 99.23% Unkown
HY-136252 BSJ-04-132 Inhibitor 99.07% Unkown
HY-116035 Nimbolide Inhibitor 99.72% Unkown
HY-114177 Ebvaciclib Inhibitor 99.98% Unkown
HY-136250 BSJ-03-204 Inhibitor 99.76% Unkown
HY-18299A Purvalanol A Inhibitor 98.30% Unkown
HY-15878 LDC000067 Inhibitor 98.09% Unkown
HY-138946 XY028-140 Inhibitor 98.42% Unkown
HY-15275 BMS-265246 Inhibitor 98.92% Unkown
HY-128669 Abemaciclib metabolite M2 Inhibitor 99.94% Unkown
HY-12445 Asnuciclib Inhibitor 99.76% Unkown
HY-13266A BS-181 hydrochloride Inhibitor 99.80% Unkown
HY-18629 SU9516 Inhibitor 99.81% Unkown
HY-119940 MC180295 Inhibitor 98.89% Unkown
HY-126534A Abemaciclib metabolite M18 hydrochloride Inhibitor 98.01% Unkown
HY-129336 Abemaciclib metabolite M20 Inhibitor 96.02% Unkown
HY-16559 Riviciclib hydrochloride 98.89% Unkown
HY-15569 NU6102 Inhibitor 99.23% Unkown
HY-129180 XY028-133 Inhibitor 98.62% Unkown
HY-50767S Palbociclib-d8 Inhibitor 99.84% Unkown
HY-15889 AMG 925 Inhibitor 98.20% Unkown
HY-148062 RSS0680 98.03% Unkown
HY-107419 NU6140 Inhibitor 99.07% Unkown
HY-112243A Cimpuciclib tosylate Inhibitor 99.16% Unkown
HY-114339 CDK4/6-IN-2 Inhibitor 99.82% Unkown
HY-126251 CDK9-IN-7 Inhibitor 98.05% Unkown
HY-142076 CDK4/6-IN-15 Inhibitor 96.15% Unkown
HY-103380 NSC 625987 Inhibitor 98.58% Unkown
HY-111207 CA224 Inhibitor 99.94% Unkown
HY-100429 CAN508 Inhibitor 99.59% Unkown
HY-148061 DB1113 99.28% Unkown
HY-148365 NecroIr1 Inhibitor 98.02% Unkown
HY-153556 GW297361 Inhibitor 98.13% Unkown
HY-112822 ON-013100 Inhibitor 98.66% Unkown
HY-103712C Samuraciclib hydrochloride hydrate Inhibitor 99.88% Unkown
HY-100624 Ryuvidine Inhibitor 99.40% Unkown
HY-136726 CGP-82996 Inhibitor 98.12% Unkown
HY-152263 HEMTAC CDK4/6 degrader 1 Inhibitor / Unkown
HY-148366 NecroIr2 Inhibitor 98.99% Unkown
HY-112346 RGB-286147 Inhibitor 98.60% Unkown
HY-13266 BS-181 Inhibitor 98.10% Unkown
HY-15889A AMG 925 HCl Inhibitor / Unkown
HY-126534 Abemaciclib metabolite M18 Inhibitor / Unkown
HY-163786 PROTAC CDK4/6 degrader 1 Degrader 98.88% Unkown
HY-129336S Abemaciclib metabolite M20-d8 Inhibitor 99.26% Unkown
HY-112243 Cimpuciclib Inhibitor / Unkown
HY-126244 CDK4/6-IN-3 Inhibitor / Unkown
HY-159155 CDK2/4-IN-1 Inhibitor / Unkown
HY-162530 CDK4/6-IN-20 Inhibitor / Unkown
HY-115992 CDK4/6-IN-9 Inhibitor / Unkown
HY-162529 CDK4/6-IN-19 Inhibitor / Unkown
HY-163856 CDK7-IN-30 Inhibitor / Unkown
HY-115993 CDK4/6-IN-10 Inhibitor / Unkown
HY-112328 Fascaplysin Inhibitor / Unkown
HY-163787 YY173 Inhibitor / Unkown
HY-162619 CDK9-IN-33 Inhibitor / Unkown
HY-143257 CDK4/6-IN-7 Inhibitor / Unkown
HY-153336 CDK-IN-12 Inhibitor / Unkown
HY-163640 CDK4 degrader 1 Degrader / Unkown
HY-115904 FLT3/CDK4-IN-1 Inhibitor / Unkown
HY-148213 CDK2/4/6-IN-1 Inhibitor / Unkown
HY-151898 CDK4/6-IN-14 Inhibitor / Unkown
HY-112418 CDK4/6-IN-18 Inhibitor / Unkown
HY-142696 CDK6/PIM1-IN-1 Inhibitor / Unkown
HY-155787 SHR5428 Inhibitor / Unkown
HY-164376A CDK4/6-IN-21 maleate Inhibitor / Unkown
HY-155602 CDK2-IN-18 Inhibitor / Unkown
HY-168664 CPD-39 Degrader / Unkown
HY-148214 CDK2/4/6-IN-2 Inhibitor / Unkown
HY-147409 Ulecaciclib Inhibitor / Unkown
HY-123034 CDKI-83 Inhibitor / Unkown
HY-141685 3-Methylthienyl-carbonyl-JNJ-7706621 Inhibitor / Unkown
HY-153088 CDK4/6-IN-16 Inhibitor / Unkown
HY-111932 Indirubin-5-sulfonate Inhibitor / Unkown
HY-115942 Anticancer agent 29 Inhibitor / Unkown
HY-160941 CDK2-IN-29 Inhibitor / Unkown
HY-146276 CDK/HDAC-IN-2 Inhibitor / Unkown
HY-151071 TMX-3013 Inhibitor / Unkown
HY-146253 CDK1/2/4-IN-1 Inhibitor / Unkown
HY-115909 ZDLD20 Inhibitor 99.84% Unkown
HY-115908 ZDLD13 Inhibitor / Unkown
HY-150609 SHP2/CDK4-IN-1 Inhibitor / Unkown
HY-168660 CPD-10 Degrader / Unkown
HY-143258 CDK4/6-IN-8 Inhibitor / Unkown
HY-164376 CDK4/6-IN-21 Inhibitor / Unkown
HY-146213 CDK4/6-IN-12 Inhibitor / Unkown
HY-112450 Olomoucine II Inhibitor / Unkown
HY-123045 PNU-292137 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cdk4 NCBI NCBI:1019