Tlr4 - toll-like receptor 4 Gene

Mus musculus

Also known as Lps; Ly87; Ran/M1; Rasl2-8

Gene ID: 21898 | Gene type: protein coding

About Tlr4

Chromosome 4: 66,745,821-66,848,521 forward strand.GRCm39:CM000997.3

This gene has 4 transcripts (splice variants), 127 orthologues, 23 paralogues and is associated with 133 phenotypes. Broad expression in bladder adult (RPKM 2.), subcutaneous fat pad adult (RPKM 1.2) and 2 other tissues.

Summary

This gene belongs to the evolutionarily-conserved Toll-like Receptor family, whose members are type-1 transmembrane proteins that are involved in innate immunity. Toll-like receptors are characterized by an extracellular leucine-rich repeat domain that functions in ligand recognition and an intracellular toll/interleukin-1 receptor-like domain that is crucial for signal transduction. The receptor encoded by this gene mediates the innate immune response to Bacterial lipopolysaccharide, a major component of the outer membrane of Gram-negative bacteria, through synthesis of pro-inflammatory cytokines and chemokines. In addition, this protein can recognize other pathogens from Gram-negative and Gram-positive bacteria as well as viral components. Mice deficient in this gene display a number of immune response-related phenotypes including hyporesponsiveness to Bacterial lipopolysaccharide and increased levels of respiratory syncytial virus compared to controls. [provided by RefSeq, Sep 2015]

Tlr4 Products(1)

mRNA	Protein	Name
NM_021297.3	NP_067272.1	toll-like receptor 4 precursor

Tlr4 Protein Structure

PLN00113

LRR_RI

PPP1R42

LRR_RI

TIR

0
200
400
600
835 a.a.

Protein Preferred Names

Protein Names

toll-like receptor 4

Toll like receptor 4

lipopolysaccharide response

Related Agents

Approval

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-130320	Monophosphoryl lipid A	Agonist	≥99.0%	Unkown
HY-107352	Fosfenopril	Inhibitor	99.89%	Unkown

Clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Phase
HY-D1056	Lipopolysaccharides, from E. coli O55:B5	Activator	/	Phase 4
HY-N8277	Kdo2-Lipid A ammonium	Activator	99.00%	Phase 4
HY-11109	Resatorvid	Inhibitor	99.95%	Phase 3
HY-105070	Eritoran	Antagonist	/	Phase 3

Pre-clinical Phase

Bioactive Molecules (30)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-107575	TLR4-IN-C34	Inhibitor	99.90%	Unkown
HY-N0108	Physcion	Inhibitor	99.10%	Unkown
HY-N0703	Schaftoside	Inhibitor	99.67%	Unkown
HY-U00435	Neoseptin 3	Agonist	99.57%	Unkown
HY-116213	Sparstolonin B	Antagonist	99.54%	Unkown
HY-N6673	Okanin	Inhibitor	99.98%	Unkown
HY-N6612	D-Glucuronic acid	Agonist	≥97.0%	Unkown
HY-N1346	Robinin	Inhibitor	98.77%	Unkown
HY-N0774	Isofraxidin	Inhibitor	99.00%	Unkown
HY-125171	IAXO-102	Antagonist	≥98.0%	Unkown
HY-124750	NecroX-7	Inhibitor	99.69%	Unkown
HY-135042	CAY10614	Antagonist	98.04%	Unkown
HY-126154	L48H37	Inhibitor	97.05%	Unkown
HY-N2345	Procyanidin B3	Inhibitor	99.63%	Unkown
HY-18325	AN-3485	Inhibitor	95.63%	Unkown
HY-N2055	Kaempferol 3-O-sophoroside	Inhibitor	99.84%	Unkown
HY-W082785A	L6H21	Inhibitor	99.46%	Unkown
HY-P10208A	RKH acetate	Antagonist	99.45%	Unkown
HY-N0392	Polygalasaponin F	Inhibitor	99.85%	Unkown
HY-146195	MAPK-IN-1	Inhibitor	95.85%	Unkown
HY-Y0278	Chloranil	Inducer	98%	Unkown
HY-145245	TLR4-IN-C34-C2-amide-C6-OH	Inhibitor	99.62%	Unkown
HY-169057	BI1543673	Inhibitor	/	Unkown
HY-168010	RC529-MDP	Activator	/	Unkown
HY-14750	Rabeximod		/	Unkown
HY-146560	Xanthine oxidase-IN-6	Inhibitor	/	Unkown
HY-145255	Tri(TLR4-IN-C34-C2-amide-C3-amide-PEG1)-amide-C3-COOH	Inhibitor	/	Unkown
HY-145253	Tri(TLR4-IN-C34-C2-amide-PEG1)-amide-C3-COOH	Inhibitor	/	Unkown
HY-N8903	Mumefural	Inhibitor	/	Unkown
HY-162004	NF-κB-IN-14	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tlr4	NCBI	NCBI:7099

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