Dracorhodin perchlorate  (Synonyms: Dracohodin perochlorate)

Dracorhodin perchlorate (Dracohodin perochlorate) is a natural product. Dracorhodin perchlorate can be obtained from the natural active molecule Dragon's blood. Dracorhodin perchlorate inhibits PI3K/Akt and NF-κB activation, upregulates p53 expression, activates caspase, produces ROS, and promotes Apoptosis. Dracorhodin perchlorate regulates the TLR4. Dracorhodin perchlorate promotes wound healing, improves diabetes. Dracorhodin perchlorate has anti-tumor activity against prostate cancer, breast cancer, cervical cancer and other cancers^{[1][2][3][4][5][6][7][8]}.

Dracorhodin perchlorate (0-80 μM; 12-48 h) inhibits the growth of human cervical cancer HeLa cells, human malignant melanoma A375-S2 cells, human breast cancer MCF-7 cells and human histiocytic lymphoma U937 cells in a dose-and time-dependent manner^[1].
Dracorhodin perchlorate (0-200 μM; 48 h) inhibits the growth of human gastric adenocarcinoma SGC-7901 cells in a dose-dependent manner^[2].
Dracorhodin perchlorate (0.625-40 μg/mL; 24 h) promotes the proliferation of NIH/3T3 fibroblasts at concentrations of 0.625-10 μg/mL and inhibits proliferation at concentrations >20 μg/mL^[3].
Dracorhodin perchlorate (10-80 μM；12-48 h) inhibits the growth of human prostate cancer PC-3 cells in a dose-and time-dependent manner, with an IC₅₀ of 40.18 μM at 24 h^[4].
Dracorhodin perchlorate (40-150 μM; 12-48 h) inhibits the growth of MCF-7 cells in a dose-and time-dependent manner^[5].
Dracorhodin perchlorate (10 μg/mL; 3-9 h) upregulates Pdx1 expression in INS-1 cells^[7].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Dracorhodin perchlorate (2.5-10 μg/mL；applied as an ointment；twice daily；0-14 days) promotes wound healing in rats, as evidenced by increased wound healing rate, enhanced fibroblast proliferation in wound tissue, and up -regulation of phosphorylated-ERK in wound tissue^[3].
Dracorhodin perchlorate (200 μg/mL; topical application) promotes skin wound healing, collagen deposition, and microvascular formation in diabetic rats by regulating the TLR4 pathway and related inflammatory factors^[6].
Dracorhodin perchlorate (5-20 mg/kg; i.p.; every other day; 30 d) lowers blood glucose, raises insulin levels, enhances Pdx1 expression, increases islet size and number, and shows protective effects on islets and β-cells in diabetic mice^[7].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

366.75

C₁₇H₁₅ClO₇

125536-25-6

Solid

Yellow to orange

CC1=C(OC)C2=CC=C(C3=CC=CC=C3)[O+]=C2C=C1O.O=Cl(=O)([O-])=O

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

• [1]. Rasul A, et al. Dracorhodin perchlorate inhibits PI3K/Akt and NF-κB activation, up-regulates the expression of p53, and enhances apoptosis. Apoptosis. 2012 Oct;17(10):1104-19.  [Content Brief]

  [2]. Xia M, et al. Dracorhodin perchlorate induces apoptosis via activation of caspases and generation of reactive oxygen species. J Pharmacol Sci. 2004 Jun;95(2):273-83.  [Content Brief]

  [3]. Jiang X, et al. Dracorhodin perchlorate regulates fibroblast proliferation to promote rat's wound healing. J Pharmacol Sci. 2018 Feb;136(2):66-72.  [Content Brief]

  [4]. He Y, et al. Dracorhodin perchlorate suppresses proliferation and induces apoptosis in human prostate cancer cell line PC-3. J Huazhong Univ Sci Technolog Med Sci. 2011 Apr;31(2):215.  [Content Brief]

  [5]. Yu JH, et al. Dracorhodin perchlorate induced human breast cancer MCF-7 apoptosis through mitochondrial pathways. Int J Med Sci. 2013 Jul 7;10(9):1149-56.  [Content Brief]

  [6]. Xiong Z, et al. Dracorhodin Perchlorate Regulates the Expression of Inflammatory Cytokines through the TLR4 Pathway and Improves Skin Wound Healing in Diabetic Rats. Evid Based Complement Alternat Med. 2022 Apr 14;2022:9050686.  [Content Brief]

  [7]. Liu L, et al. Dracorhodin perchlorate protects pancreatic β-cells against glucotoxicity- or lipotoxicity-induced dysfunction and apoptosis in vitro and in vivo. FEBS J. 2019 Sep;286(18):3718-3736.  [Content Brief]

  [8]. Chen X, et al. Dracorhodin perchlorate induces the apoptosis of glioma cells. Oncol Rep. 2016 Apr;35(4):2364-72.  [Content Brief]