2. Gene
  3. Cd4 - Cd4 molecule Gene

Cd4 - Cd4 molecule Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as p55; W3/25

Gene ID: 24932 | Gene type: protein coding

About Cd4

Summary

Enables immunoglobulin binding activity; protein tyrosine kinase binding activity; and signaling receptor binding activity. Involved in several processes, including positive regulation of calcium ion transport into cytosol; response to estradiol; and response to vitamin D. Located in external side of plasma membrane. Used to study septic arthritis and sialadenitis. Human ortholog(s) of this gene implicated in immunodeficiency 79. Orthologous to human CD4 (CD4 molecule). [provided by Alliance of Genome Resources, Apr 2022]

Cd4 Products(1)

mRNA Protein Name
NM_012705.1 NP_036837.1 T-cell surface glycoprotein CD4 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables immunoglobulin binding IDA
IDA: Inferred from direct assay
2338715 RGD
enables protein kinase binding IPI
IPI: Inferred from physical interaction
1372996 RGD
enables protein tyrosine kinase binding IDA
IDA: Inferred from direct assay
8959663 RGD
enables signaling receptor binding IPI
IPI: Inferred from physical interaction
12115612 RGD
Biological Process GO Annotation Evidence Reference Source
involved in cellular response to ionomycin IEP
IEP: Inferred from expression pattern
25678251 RGD
involved in positive regulation of T cell proliferation IMP
IMP: Inferred from mutant phenotype
15000837 RGD
involved in positive regulation of calcium ion transport into cytosol IDA
IDA: Inferred from direct assay
8959663 RGD
involved in response to estradiol IEP
IEP: Inferred from expression pattern
2478646 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
8214423 RGD
involved in response to methamphetamine hydrochloride IEP
IEP: Inferred from expression pattern
25678251 RGD
involved in response to vitamin D IEP
IEP: Inferred from expression pattern
8759780 RGD
Cellular Component GO Annotation Evidence Reference Source
located in cell surface IDA
IDA: Inferred from direct assay
15474526 RGD
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
3159821 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

T-cell surface glycoprotein CD4

CD4 antigen

T-cell surface antigen T4/Leu-3

W3/25 antigen

Recombinant Cd4 Proteins

Cat. No. Product Name Accession Purity
HY-P72905 CD4 Protein, Rat (HEK293, His) P05540 (K28-T394) ≥95%

Related Agents

Approval
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0689A Indinavir sulfate 99.97% Yes
HY-15440A Fostemsavir Inhibitor 99.52% Unkown
HY-15440B Fostemsavir Tris Inhibitor 99.94% Unkown
HY-B0689 Indinavir / Unkown
HY-B0689B Indinavir sulfate ethanolate / Unkown
Inhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P99222 Teplizumab ≥99.0% Unkown
HY-P99028 Ibalizumab Inhibitor 99.52% Unkown
Clinical Phase
Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Phase
HY-105037A Forigerimod TFA Inhibitor 98.89% Phase 3
HY-148808 Zelasudil Inhibitor 99.86% Phase 2
HY-P0272 Peptide T Inhibitor 98.86% Phase 2
HY-P0272A Peptide T TFA Inhibitor / Phase 2
HY-14135 BMS 488043 Inhibitor / Phase 2
HY-15440 Temsavir Inhibitor 98.06% Phase 1
Inhibitory Antibodies (5)
Cat. No. Product Name Effect
Purity Phase
HY-P99266 Zanolimumab Inhibitor 99.21% Phase 3
HY-P9998 Semzuvolimab Inhibitor 95.00% Phase 3
HY-P99908 Efineptakin alfa Activator / Phase 2
HY-P99607 Clenoliximab Inhibitor / Phase 2
HY-P99433 Alvircept sudotox Inhibitor / Phase 1
Pre-clinical Phase
Bioactive Molecules (68)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-150741 ODN 2216 / Unkown
HY-110382 Cyclic-di-GMP disodium Activator 99.23% Unkown
HY-150741C ODN 2216 sodium Activator 97.88% Unkown
HY-107780B Cyclic-di-GMP diammonium Activator 99.07% Unkown
HY-15898 Y-320 99.74% Unkown
HY-P2560 LCMV GP (61-80) 99.80% Unkown
HY-134809 Cyclotriazadisulfonamide Inhibitor 98.54% Unkown
HY-124750 NecroX-7 Inhibitor 99.69% Unkown
HY-P1066 Apelin-17(human, bovine) 98.29% Unkown
HY-155978A RDN2150 TFA 99.62% Unkown
HY-119347 Cirsilineol Inhibitor ≥98.0% Unkown
HY-P1064 Apelin-36(human) 98.05% Unkown
HY-139780 JNJ-61803534 Inhibitor 99.88% Unkown
HY-Y0788 Indoline 99.89% Unkown
HY-14134 BMS-378806 Inhibitor 98.94% Unkown
HY-107780 Cyclic-di-GMP Activator 98.18% Unkown
HY-157793 SMU-L11 99.64% Unkown
HY-P1997 Ferrichrome Iron-free ≥98.0% Unkown
HY-12465 Z-Ile-Leu-aldehyde 97.28% Unkown
HY-P1065 Apelin-36(rat, mouse) 99.12% Unkown
HY-W181026 KLF10-IN-1 99.84% Unkown
HY-164426 HEI3090 Activator 99.04% Unkown
HY-100039 YYA-021 Inhibitor 98.96% Unkown
HY-105037 Forigerimod Inhibitor / Unkown
HY-138115 7ß,27-Dihydroxycholesterol Activator ≥99.0% Unkown
HY-148432 FGF22-IN-1 Inhibitor 98.07% Unkown
HY-155978 RDN2150 / Unkown
HY-76648 NBD-556 Inhibitor 99.57% Unkown
HY-P1064A Apelin-36(human) TFA 98.11% Unkown
HY-16106S Talazoparib-13C,d4 99.30% Unkown
HY-W102449S 4-Acetyl-N-methylaniline-13C,d3 97.05% Unkown
HY-135432 Etrasimod arginine Modulator / Unkown
HY-106055 Murabutide Inhibitor / Unkown
HY-107780A Cyclic-di-GMP sodium Activator / Unkown
HY-111366 CD12681 Agonist / Unkown
HY-119202 (S)-BMS-378806 / Unkown
HY-121820 DMJ-I-228 Inhibitor / Unkown
HY-123312 CK-548 Inhibitor / Unkown
HY-123902 Ophiobolin C Inhibitor / Unkown
HY-126037 (±)-ML 209 Antagonist 99.87% Unkown
HY-137618B Rp-dGTPαS / Unkown
HY-137640A Sp-8-Br-cAMPS sodium Agonist / Unkown
HY-144746 PD-1/PD-L1-IN-26 Inhibitor / Unkown
HY-145491 Resolvin D5 / Unkown
HY-15091 Anisperimus / Unkown
HY-161255 3,4-DAA Inhibitor / Unkown
HY-169335 HIV-1 inhibitor-77 Inhibitor / Unkown
HY-B0094S3 Artemisinin-13C,d4 / Unkown
HY-P10308 [(Cys(Bzl)84,Glu(OBzl)85)]CD4 (81-92) / Unkown
HY-P1065A Apelin-36(rat, mouse) TFA / Unkown
HY-P1066A Apelin-17(human, bovine) TFA / Unkown
HY-P1409A ADWX 1 TFA Inhibitor / Unkown
HY-P2561 Influenza Matrix Protein (61-72) / Unkown
HY-P3554 Carbomethoxycarbonyl-D-Pro-D-Phe-OBzl Inhibitor / Unkown
HY-P5930 HOXB7 8–25 / Unkown
HY-RS02245 CD4 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-W005355S8 Sodium 2-oxobutanoate-13C,d4 / Unkown
HY-W006057AS14 Sodium 3-methyl-2-oxobutanoate-13C,d4 / Unkown
HY-Y0781S5 Pyruvic acid-13C,d4 / Unkown
HY-117160S2 4-trans-Hydroxy glibenclamide-13C,d4 / Unkown
HY-123756 NBD-10007 Inhibitor / Unkown
HY-12926 ST7612AA1 / Unkown
HY-134809A Cyclotriazadisulfonamide hydrochloride / Unkown
HY-13644 Gusperimus / Unkown
HY-154771S Clopidogrelat-13C,d4 / Unkown
HY-159123 KHK-6 Inhibitor / Unkown
HY-B0202S4 Irbesartan-13C,d4 / Unkown
HY-110216 5J-4 Inhibitor 95% Unkown
Inhibitory Antibodies (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P99999 Anti-Mouse CD4 Antibody (YTS 191) Inhibitor ≥95.0% Unkown
HY-P990792 Anti-Mouse CD4 Antibody (GK1.5) 95.00% Unkown
HY-P99680 Keliximab Inhibitor 98.23% Unkown
HY-P990861 Anti-CD4 Antibody (OKT-4) / Unkown
HY-P99790 Priliximab / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cd4 NCBI NCBI:920
Canis familiaris Cd4 NCBI NCBI:403931
Macaca fascicularis Cd4 NCBI NCBI:101864991
Mus musculus Cd4 NCBI NCBI:12504
Leporidae Cd4 NCBI
Macaca mulatta Cd4 NCBI NCBI:713807