2. Gene
  3. BRK1 - BRICK1 subunit of SCAR/WAVE actin nucleating complex Gene

BRK1 - BRICK1 subunit of SCAR/WAVE actin nucleating complex Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as MDS027; hHBrk1; C3orf10; HSPC300

Gene ID: 55845 | Gene type: protein coding

About BRK1

Cytogenetic location: 3p25.3 Genomic coordinates (GRCh38): 3:10,115,675-10,127,190 (from NCBI)

This gene has 1 transcript (splice variant) and 187 orthologues. Ubiquitous expression in fat (RPKM 95.9), kidney (RPKM 81.0) and 25 other tissues.

Summary

Enables identical protein binding activity. Contributes to small GTPase binding activity. Involved in Rac protein signal transduction and positive regulation of cellular component organization. Located in extracellular exosome. Part of SCAR complex. [provided by Alliance of Genome Resources, Apr 2022]

BRK1 Products(1)

mRNA Protein Name
NM_018462.5 NP_060932.2 protein BRICK1
Protein Preferred Names Protein Names

protein BRICK1

BRICK1, SCAR/WAVE actin nucleating complex subunit

BRK1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
BRK1 Q8WUW1 PRRG2 Homo sapiens Q8TAS3
Validated Y2H
32814053
Intra
BRK1 Q8WUW1 PRRG2 Homo sapiens Q8TAS3
Y2H Array
32814053
Intra
BRK1 Q8WUW1 PRRG2 Homo sapiens Q8TAS3
Y2H Pooling
32814053
Intra
BRK1 Q8WUW1 TIMM8A Homo sapiens O60220
Y2H Pooling
32814053
Intra
BRK1 Q8WUW1 TIMM8A Homo sapiens O60220
Validated Y2H
32814053
Intra
BRK1 Q8WUW1 TIMM8A Homo sapiens O60220
Y2H Array
32814053
Intra
BRK1 Q8WUW1 ZNG1A Homo sapiens Q9BRT8
Validated Y2H
32814053
Intra
BRK1 Q8WUW1 ZNG1A Homo sapiens Q9BRT8
Y2H Array
32814053
Intra
BRK1 Q8WUW1 ZNG1A Homo sapiens Q9BRT8
Y2H Pooling
32814053
Intra
BRK1 Q8WUW1 JPH3 Homo sapiens Q8WXH2
Y2H Array
32814053
Intra
BRK1 Q8WUW1 JPH3 Homo sapiens Q8WXH2
Y2H Pooling
32814053
Intra
BRK1 Q8WUW1 JPH3 Homo sapiens Q8WXH2
Validated Y2H
32814053
Intra
BRK1 Q8WUW1 OTUB1 Homo sapiens Q96FW1
Validated Y2H
32814053
Intra
BRK1 Q8WUW1 OTUB1 Homo sapiens Q96FW1
Y2H Pooling
32814053
Intra
BRK1 Q8WUW1 OTUB1 Homo sapiens Q96FW1
Y2H Array
32814053
Intra
BRK1 Q8WUW1 DNM2 Homo sapiens P50570-2
Y2H Pooling
32814053
Intra
BRK1 Q8WUW1 DNM2 Homo sapiens P50570-2
Validated Y2H
32814053
Intra
BRK1 Q8WUW1 DNM2 Homo sapiens P50570-2
Y2H Array
32814053
Intra
BRK1 Q8WUW1 BAG6 Homo sapiens P46379-2
Y2H Pooling
32814053
Intra
BRK1 Q8WUW1 BAG6 Homo sapiens P46379-2
Validated Y2H
32814053
Intra
BRK1 Q8WUW1 BAG6 Homo sapiens P46379-2
Y2H Array
32814053
Intra
BRK1 Q8WUW1 AKAP9 Homo sapiens Q99996-3
Y2H Array
32814053
Intra
BRK1 Q8WUW1 AKAP9 Homo sapiens Q99996-3
Validated Y2H
32814053
Intra
BRK1 Q8WUW1 AKAP9 Homo sapiens Q99996-3
Y2H Pooling
32814053
Intra
BRK1 Q8WUW1 VKORC1L1 Homo sapiens Q8N0U8
Y2H Array
32814053
Intra
BRK1 Q8WUW1 VKORC1L1 Homo sapiens Q8N0U8
Validated Y2H
32814053
Intra
BRK1 Q8WUW1 VKORC1L1 Homo sapiens Q8N0U8
Y2H Pooling
32814053
Intra
BRK1 Q8WUW1 MECP2 Homo sapiens P51608
Validated Y2H
32814053
Intra
BRK1 Q8WUW1 MECP2 Homo sapiens P51608
Y2H Array
32814053
Intra
BRK1 Q8WUW1 MECP2 Homo sapiens P51608
Y2H Pooling
32814053
Intra
BRK1 Q8WUW1 WFDC5 Homo sapiens Q8TCV5
Validated Y2H
32814053
Intra
BRK1 Q8WUW1 WFDC5 Homo sapiens Q8TCV5
Y2H Array
32814053
Intra
BRK1 Q8WUW1 WFDC5 Homo sapiens Q8TCV5
Y2H Pooling
32814053
Intra
BRK1 Q8WUW1 SPDEF Homo sapiens O95238
Validated Y2H
32814053
Intra
BRK1 Q8WUW1 SPDEF Homo sapiens O95238
Y2H Array
32814053
Intra
BRK1 Q8WUW1 SPDEF Homo sapiens O95238
Y2H Pooling
32814053
Intra
BRK1 Q8WUW1 TMEM95 Homo sapiens Q3KNT9
Validated Y2H
32814053
Intra
BRK1 Q8WUW1 TMEM95 Homo sapiens Q3KNT9
Y2H Pooling
32814053
Intra
BRK1 Q8WUW1 TMEM95 Homo sapiens Q3KNT9
Y2H Array
32814053
Intra
BRK1 Q8WUW1 PRKN Homo sapiens O60260-5
Validated Y2H
32814053
Intra
BRK1 Q8WUW1 PRKN Homo sapiens O60260-5
Y2H Array
32814053
Intra
BRK1 Q8WUW1 PRKN Homo sapiens O60260-5
Y2H Pooling
32814053
Intra
BRK1 Q8WUW1 DPP9 Homo sapiens Q86TI2-2
Validated Y2H
32814053
Intra
BRK1 Q8WUW1 DPP9 Homo sapiens Q86TI2-2
Y2H Array
32814053
Intra
BRK1 Q8WUW1 DPP9 Homo sapiens Q86TI2-2
Y2H Pooling
32814053
Intra
BRK1 Q8WUW1 PHF19 Homo sapiens Q5T6S3
Y2H Array
32814053
Intra
BRK1 Q8WUW1 PHF19 Homo sapiens Q5T6S3
Validated Y2H
32814053
Intra
BRK1 Q8WUW1 PHF19 Homo sapiens Q5T6S3
Y2H Pooling
32814053
Intra
BRK1 Q8WUW1 RNF20 Homo sapiens Q5VTR2
Validated Y2H
32814053
Intra
BRK1 Q8WUW1 RNF20 Homo sapiens Q5VTR2
Y2H Pooling
32814053
Intra
BRK1 Q8WUW1 RNF20 Homo sapiens Q5VTR2
Y2H Array
32814053
Intra
BRK1 Q8WUW1 RNF20 Homo sapiens Q5VTR2
Anti Tag CoIP
33961781
Intra
BRK1 Q8WUW1 PER1 Homo sapiens O15534
Validated Y2H
32814053
Intra
BRK1 Q8WUW1 PER1 Homo sapiens O15534
Y2H Pooling
32814053
Intra
BRK1 Q8WUW1 PER1 Homo sapiens O15534
Y2H Array
32814053
Intra
BRK1 Q8WUW1 DCTN1 Homo sapiens Q14203-5
Y2H Pooling
32814053
Intra
BRK1 Q8WUW1 DCTN1 Homo sapiens Q14203-5
Validated Y2H
32814053
Intra
BRK1 Q8WUW1 DCTN1 Homo sapiens Q14203-5
Y2H Array
32814053
Intra
BRK1 Q8WUW1 BCKDK Homo sapiens O14874-2
Y2H Pooling
32814053
Intra
BRK1 Q8WUW1 BCKDK Homo sapiens O14874-2
Validated Y2H
32814053
Intra
BRK1 Q8WUW1 BCKDK Homo sapiens O14874-2
Y2H Array
32814053
Intra
BRK1 Q8WUW1 TUBA1B Homo sapiens P68363-2
Y2H Array
32814053
Intra
BRK1 Q8WUW1 TUBA1B Homo sapiens P68363-2
Y2H Pooling
32814053
Intra
BRK1 Q8WUW1 TUBA1B Homo sapiens P68363-2
Validated Y2H
32814053
Intra
BRK1 Q8WUW1 NUP58 Homo sapiens Q9BVL2
Validated Y2H
32814053
Intra
BRK1 Q8WUW1 NUP58 Homo sapiens Q9BVL2
Y2H Array
32814053
Intra
BRK1 Q8WUW1 NUP58 Homo sapiens Q9BVL2
Y2H Pooling
32814053
Intra
BRK1 Q8WUW1 CDC37L1 Homo sapiens Q7L3B6
Validated Y2H
32814053
Intra
BRK1 Q8WUW1 CDC37L1 Homo sapiens Q7L3B6
Y2H Pooling
32814053
Intra
BRK1 Q8WUW1 CDC37L1 Homo sapiens Q7L3B6
Y2H Array
32814053
Intra
BRK1 Q8WUW1 ZNHIT1 Homo sapiens O43257
Validated Y2H
32814053
Intra
BRK1 Q8WUW1 ZNHIT1 Homo sapiens O43257
Y2H Array
32814053
Intra
BRK1 Q8WUW1 ZNHIT1 Homo sapiens O43257
Y2H Pooling
32814053
Intra
BRK1 Q8WUW1 PRMT5 Homo sapiens O14744
Y2H Array
32814053
Intra
BRK1 Q8WUW1 PRMT5 Homo sapiens O14744
Validated Y2H
32814053
Intra
BRK1 Q8WUW1 PRMT5 Homo sapiens O14744
Y2H Pooling
32814053
Intra
BRK1 Q8WUW1 EEF1G Homo sapiens P26641
Validated Y2H
32814053
Intra
BRK1 Q8WUW1 EEF1G Homo sapiens P26641
Y2H Array
32814053
Intra
BRK1 Q8WUW1 EEF1G Homo sapiens P26641
Y2H Pooling
32814053
Intra
BRK1 Q8WUW1 VDAC2 Homo sapiens P45880
Validated Y2H
32814053
Intra
BRK1 Q8WUW1 VDAC2 Homo sapiens P45880
Y2H Array
32814053
Intra
BRK1 Q8WUW1 VDAC2 Homo sapiens P45880
Y2H Pooling
32814053
Intra
BRK1 Q8WUW1 CCT6A Homo sapiens P40227
Y2H Pooling
32814053
Intra
BRK1 Q8WUW1 CCT6A Homo sapiens P40227
Validated Y2H
32814053
Intra
BRK1 Q8WUW1 CCT6A Homo sapiens P40227
Y2H Array
32814053
Intra
BRK1 Q8WUW1 RNF11 Homo sapiens Q9Y3C5
Y2H Pooling
32814053
Intra
BRK1 Q8WUW1 RNF11 Homo sapiens Q9Y3C5
Validated Y2H
32814053
Intra
BRK1 Q8WUW1 RNF11 Homo sapiens Q9Y3C5
Y2H Array
32814053
Intra
BRK1 Q8WUW1 DTNBP1 Homo sapiens Q96EV8
Validated Y2H
25416956
Intra
BRK1 Q8WUW1 UBE2K Homo sapiens P61086
Y2H Pooling
32814053
Intra
BRK1 Q8WUW1 UBE2K Homo sapiens P61086
Validated Y2H
32814053
Intra
BRK1 Q8WUW1 UBE2K Homo sapiens P61086
Y2H Array
32814053
Intra
BRK1 Q8WUW1 PMP22 Homo sapiens A0A6Q8PF08
Validated Y2H
32814053
Intra
BRK1 Q8WUW1 PMP22 Homo sapiens A0A6Q8PF08
Y2H Array
32814053
Intra
BRK1 Q8WUW1 PMP22 Homo sapiens A0A6Q8PF08
Y2H Pooling
32814053
Intra
BRK1 Q8WUW1 SPRED1 Homo sapiens Q7Z699
Y2H Array
32814053
Intra
BRK1 Q8WUW1 SPRED1 Homo sapiens Q7Z699
Y2H Pooling
32814053
Intra
BRK1 Q8WUW1 SPRED1 Homo sapiens Q7Z699
Validated Y2H
32814053
Intra
BRK1 Q8WUW1 A2M Homo sapiens P01023
Validated Y2H
32814053
Intra
BRK1 Q8WUW1 A2M Homo sapiens P01023
Y2H Pooling
32814053
Intra
BRK1 Q8WUW1 A2M Homo sapiens P01023
Y2H Array
32814053
Intra
BRK1 Q8WUW1 MAGEB6 Homo sapiens Q8N7X4
Y2H Array
32814053
Intra
BRK1 Q8WUW1 MAGEB6 Homo sapiens Q8N7X4
Y2H Pooling
32814053
Intra
BRK1 Q8WUW1 MAGEB6 Homo sapiens Q8N7X4
Validated Y2H
32814053
Intra
BRK1 Q8WUW1 NDUFV2 Homo sapiens P19404
Y2H Array
32814053
Intra
BRK1 Q8WUW1 NDUFV2 Homo sapiens P19404
Y2H Pooling
32814053
Intra
BRK1 Q8WUW1 NDUFV2 Homo sapiens P19404
Validated Y2H
32814053
Intra
BRK1 Q8WUW1 CFAP68 Homo sapiens Q9H5F2
Validated Y2H
32814053
Intra
BRK1 Q8WUW1 CFAP68 Homo sapiens Q9H5F2
Y2H Pooling
32814053
Intra
BRK1 Q8WUW1 CFAP68 Homo sapiens Q9H5F2
Y2H Array
32814053
Intra
BRK1 Q8WUW1 MPC2 Homo sapiens O95563
Validated Y2H
32814053
Intra
BRK1 Q8WUW1 MPC2 Homo sapiens O95563
Y2H Array
32814053
Intra
BRK1 Q8WUW1 MPC2 Homo sapiens O95563
Y2H Pooling
32814053
Intra
BRK1 Q8WUW1 LAPTM4A Homo sapiens Q15012
Validated Y2H
32814053
Intra
BRK1 Q8WUW1 LAPTM4A Homo sapiens Q15012
Y2H Array
32814053
Intra
BRK1 Q8WUW1 LAPTM4A Homo sapiens Q15012
Y2H Pooling
32814053
Intra
BRK1 Q8WUW1 BRME1 Homo sapiens Q0VDD7
Validated Y2H
32814053
Intra
BRK1 Q8WUW1 BRME1 Homo sapiens Q0VDD7
Y2H Array
32814053
Intra
BRK1 Q8WUW1 BRME1 Homo sapiens Q0VDD7
Y2H Pooling
32814053
Intra
BRK1 Q8WUW1 GFAP Homo sapiens P14136
Validated Y2H
32814053
Intra
BRK1 Q8WUW1 GFAP Homo sapiens P14136
Y2H Array
32814053
Intra
BRK1 Q8WUW1 GFAP Homo sapiens P14136
Y2H Pooling
32814053
Intra
BRK1 Q8WUW1 NME4 Homo sapiens O00746
Y2H Pooling
32814053
Intra
BRK1 Q8WUW1 NME4 Homo sapiens O00746
Validated Y2H
32814053
Intra
BRK1 Q8WUW1 NME4 Homo sapiens O00746
Y2H Array
32814053
Intra
BRK1 Q8WUW1 HSBP1 Homo sapiens O75506
Anti Tag CoIP
33961781
Intra
BRK1 Q8WUW1 HSBP1 Homo sapiens O75506
Y2H Prey Pooling
32296183
Intra
BRK1 Q8WUW1 HSBP1 Homo sapiens O75506
Y2H Array
32296183
Intra
BRK1 Q8WUW1 PRPH Homo sapiens P41219
Validated Y2H
32814053
Intra
BRK1 Q8WUW1 PRPH Homo sapiens P41219
Y2H Array
32814053
Intra
BRK1 Q8WUW1 PRPH Homo sapiens P41219
Y2H Pooling
32814053
Intra
BRK1 Q8WUW1 RYBP Homo sapiens Q8N488
Y2H Array
32814053
Intra
BRK1 Q8WUW1 RYBP Homo sapiens Q8N488
Validated Y2H
32814053
Intra
BRK1 Q8WUW1 RYBP Homo sapiens Q8N488
Y2H Pooling
32814053
Intra
BRK1 Q8WUW1 SPPL2B Homo sapiens Q8TCT7-2
Validated Y2H
32814053
Intra
BRK1 Q8WUW1 SPPL2B Homo sapiens Q8TCT7-2
Y2H Array
32814053
Intra
BRK1 Q8WUW1 SPPL2B Homo sapiens Q8TCT7-2
Y2H Pooling
32814053
Intra
BRK1 Q8WUW1 DBH Homo sapiens P09172
Y2H Array
32814053
Intra
BRK1 Q8WUW1 DBH Homo sapiens P09172
Y2H Pooling
32814053
Intra
BRK1 Q8WUW1 DBH Homo sapiens P09172
Validated Y2H
32814053
Intra
BRK1 Q8WUW1 P2RY2 Homo sapiens P41231
Y2H Array
32814053
Intra
BRK1 Q8WUW1 P2RY2 Homo sapiens P41231
Validated Y2H
32814053
Intra
BRK1 Q8WUW1 P2RY2 Homo sapiens P41231
Y2H Pooling
32814053
Intra
BRK1 Q8WUW1 IFT20 Homo sapiens Q8IY31-3
Y2H Array
32814053
Intra
BRK1 Q8WUW1 IFT20 Homo sapiens Q8IY31-3
Y2H Pooling
32814053
Intra
BRK1 Q8WUW1 IFT20 Homo sapiens Q8IY31-3
Validated Y2H
32814053
Intra
BRK1 Q8WUW1 NDEL1 Homo sapiens Q9GZM8
Y2H Array
32814053
Intra
BRK1 Q8WUW1 NDEL1 Homo sapiens Q9GZM8
Validated Y2H
32296183
Intra
BRK1 Q8WUW1 NDEL1 Homo sapiens Q9GZM8
Anti Tag CoIP
33961781
Intra
BRK1 Q8WUW1 NDEL1 Homo sapiens Q9GZM8
Y2H Array
32296183
Intra
BRK1 Q8WUW1 NDEL1 Homo sapiens Q9GZM8
Y2H Pooling
32814053
Intra
BRK1 Q8WUW1 NDEL1 Homo sapiens Q9GZM8
Y2H Prey Pooling
32296183
Intra
BRK1 Q8WUW1 NDEL1 Homo sapiens Q9GZM8
Validated Y2H
32814053
Intra
BRK1 Q8WUW1 MRFAP1 Homo sapiens Q9Y605
Validated Y2H
32814053
Intra
BRK1 Q8WUW1 MRFAP1 Homo sapiens Q9Y605
Y2H Pooling
32814053
Intra
BRK1 Q8WUW1 MRFAP1 Homo sapiens Q9Y605
Y2H Array
32814053
Intra
BRK1 Q8WUW1 MRFAP1 Homo sapiens Q9Y605
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Hemangioma Of Lung

Pulmonary Hemangioma
Retinal Hemangioblastoma

Capillary Hemangioma Of Retina
Cardiac Tamponade

Pericardial Tamponade

Rose'S Tamponade
Patent Foramen Ovale

Atrial Septal Defect Within Oval Fossa

Foramen Ovale Patent

Ostium Secundum Atrial Septal Defect

Atrial Septal Defect, Ostium Secundum Type

Foramen Ovale, Patent

Defect, Patent Or Persistent, Ostium Secundum

Ostium Secundum Type Atrial Septal Defect

Persistent Ostium Secundum

Asd Ostium Secundum Type

Ostium Secundum Asd

Osasd

Asd, Ostium Secundum Type

Pfo - [Patent Foramen Ovale]

Open Foramen Ovale

Open Oval Foramen

Persistent Foramen Ovale

Secundum Atrial Septal Defect
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS01625 BRK1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus BRK1 MGD MGI:1915406
Macaca mulatta BRK1 VGNC VGNC:110380
Bos taurus BRK1 VGNC VGNC:26570
Felis catus BRK1 VGNC VGNC:69361
Rattus norvegicus BRK1 RGD RGD:1598136
Canis familiaris BRK1 VGNC VGNC:54277