BRK1 - BRICK1 subunit of SCAR/WAVE actin nucleating complex Gene

Homo sapiens

Also known as MDS027; hHBrk1; C3orf10; HSPC300

Gene ID: 55845 | Gene type: protein coding

About BRK1

Cytogenetic location: 3p25.3 Genomic coordinates (GRCh38): 3:10,115,675-10,127,190 (from NCBI)

This gene has 1 transcript (splice variant) and 187 orthologues. Ubiquitous expression in fat (RPKM 95.9), kidney (RPKM 81.0) and 25 other tissues.

Summary

Enables identical protein binding activity. Contributes to small GTPase binding activity. Involved in Rac protein signal transduction and positive regulation of cellular component organization. Located in extracellular exosome. Part of SCAR complex. [provided by Alliance of Genome Resources, Apr 2022]

BRK1 Products(1)

mRNA	Protein	Name
NM_018462.5	NP_060932.2	protein BRICK1

Protein Preferred Names

Protein Names

protein BRICK1

BRICK1, SCAR/WAVE actin nucleating complex subunit

BRK1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	BRK1	Q8WUW1	PRRG2	Homo sapiens	Q8TAS3	Validated Y2H	32814053
Intra	BRK1	Q8WUW1	PRRG2	Homo sapiens	Q8TAS3	Y2H Array	32814053
Intra	BRK1	Q8WUW1	PRRG2	Homo sapiens	Q8TAS3	Y2H Pooling	32814053
Intra	BRK1	Q8WUW1	TIMM8A	Homo sapiens	O60220	Y2H Pooling	32814053
Intra	BRK1	Q8WUW1	TIMM8A	Homo sapiens	O60220	Validated Y2H	32814053
Intra	BRK1	Q8WUW1	TIMM8A	Homo sapiens	O60220	Y2H Array	32814053
Intra	BRK1	Q8WUW1	ZNG1A	Homo sapiens	Q9BRT8	Validated Y2H	32814053
Intra	BRK1	Q8WUW1	ZNG1A	Homo sapiens	Q9BRT8	Y2H Array	32814053
Intra	BRK1	Q8WUW1	ZNG1A	Homo sapiens	Q9BRT8	Y2H Pooling	32814053
Intra	BRK1	Q8WUW1	JPH3	Homo sapiens	Q8WXH2	Y2H Array	32814053
Intra	BRK1	Q8WUW1	JPH3	Homo sapiens	Q8WXH2	Y2H Pooling	32814053
Intra	BRK1	Q8WUW1	JPH3	Homo sapiens	Q8WXH2	Validated Y2H	32814053
Intra	BRK1	Q8WUW1	OTUB1	Homo sapiens	Q96FW1	Validated Y2H	32814053
Intra	BRK1	Q8WUW1	OTUB1	Homo sapiens	Q96FW1	Y2H Pooling	32814053
Intra	BRK1	Q8WUW1	OTUB1	Homo sapiens	Q96FW1	Y2H Array	32814053
Intra	BRK1	Q8WUW1	DNM2	Homo sapiens	P50570-2	Y2H Pooling	32814053
Intra	BRK1	Q8WUW1	DNM2	Homo sapiens	P50570-2	Validated Y2H	32814053
Intra	BRK1	Q8WUW1	DNM2	Homo sapiens	P50570-2	Y2H Array	32814053
Intra	BRK1	Q8WUW1	BAG6	Homo sapiens	P46379-2	Y2H Pooling	32814053
Intra	BRK1	Q8WUW1	BAG6	Homo sapiens	P46379-2	Validated Y2H	32814053
Intra	BRK1	Q8WUW1	BAG6	Homo sapiens	P46379-2	Y2H Array	32814053
Intra	BRK1	Q8WUW1	AKAP9	Homo sapiens	Q99996-3	Y2H Array	32814053
Intra	BRK1	Q8WUW1	AKAP9	Homo sapiens	Q99996-3	Validated Y2H	32814053
Intra	BRK1	Q8WUW1	AKAP9	Homo sapiens	Q99996-3	Y2H Pooling	32814053
Intra	BRK1	Q8WUW1	VKORC1L1	Homo sapiens	Q8N0U8	Y2H Array	32814053
Intra	BRK1	Q8WUW1	VKORC1L1	Homo sapiens	Q8N0U8	Validated Y2H	32814053
Intra	BRK1	Q8WUW1	VKORC1L1	Homo sapiens	Q8N0U8	Y2H Pooling	32814053
Intra	BRK1	Q8WUW1	MECP2	Homo sapiens	P51608	Validated Y2H	32814053
Intra	BRK1	Q8WUW1	MECP2	Homo sapiens	P51608	Y2H Array	32814053
Intra	BRK1	Q8WUW1	MECP2	Homo sapiens	P51608	Y2H Pooling	32814053
Intra	BRK1	Q8WUW1	WFDC5	Homo sapiens	Q8TCV5	Validated Y2H	32814053
Intra	BRK1	Q8WUW1	WFDC5	Homo sapiens	Q8TCV5	Y2H Array	32814053
Intra	BRK1	Q8WUW1	WFDC5	Homo sapiens	Q8TCV5	Y2H Pooling	32814053
Intra	BRK1	Q8WUW1	SPDEF	Homo sapiens	O95238	Validated Y2H	32814053
Intra	BRK1	Q8WUW1	SPDEF	Homo sapiens	O95238	Y2H Array	32814053
Intra	BRK1	Q8WUW1	SPDEF	Homo sapiens	O95238	Y2H Pooling	32814053
Intra	BRK1	Q8WUW1	TMEM95	Homo sapiens	Q3KNT9	Validated Y2H	32814053
Intra	BRK1	Q8WUW1	TMEM95	Homo sapiens	Q3KNT9	Y2H Pooling	32814053
Intra	BRK1	Q8WUW1	TMEM95	Homo sapiens	Q3KNT9	Y2H Array	32814053
Intra	BRK1	Q8WUW1	PRKN	Homo sapiens	O60260-5	Validated Y2H	32814053
Intra	BRK1	Q8WUW1	PRKN	Homo sapiens	O60260-5	Y2H Array	32814053
Intra	BRK1	Q8WUW1	PRKN	Homo sapiens	O60260-5	Y2H Pooling	32814053
Intra	BRK1	Q8WUW1	DPP9	Homo sapiens	Q86TI2-2	Validated Y2H	32814053
Intra	BRK1	Q8WUW1	DPP9	Homo sapiens	Q86TI2-2	Y2H Array	32814053
Intra	BRK1	Q8WUW1	DPP9	Homo sapiens	Q86TI2-2	Y2H Pooling	32814053
Intra	BRK1	Q8WUW1	PHF19	Homo sapiens	Q5T6S3	Y2H Array	32814053
Intra	BRK1	Q8WUW1	PHF19	Homo sapiens	Q5T6S3	Validated Y2H	32814053
Intra	BRK1	Q8WUW1	PHF19	Homo sapiens	Q5T6S3	Y2H Pooling	32814053
Intra	BRK1	Q8WUW1	RNF20	Homo sapiens	Q5VTR2	Validated Y2H	32814053
Intra	BRK1	Q8WUW1	RNF20	Homo sapiens	Q5VTR2	Y2H Pooling	32814053
Intra	BRK1	Q8WUW1	RNF20	Homo sapiens	Q5VTR2	Y2H Array	32814053
Intra	BRK1	Q8WUW1	RNF20	Homo sapiens	Q5VTR2	Anti Tag CoIP	33961781
Intra	BRK1	Q8WUW1	PER1	Homo sapiens	O15534	Validated Y2H	32814053
Intra	BRK1	Q8WUW1	PER1	Homo sapiens	O15534	Y2H Pooling	32814053
Intra	BRK1	Q8WUW1	PER1	Homo sapiens	O15534	Y2H Array	32814053
Intra	BRK1	Q8WUW1	DCTN1	Homo sapiens	Q14203-5	Y2H Pooling	32814053
Intra	BRK1	Q8WUW1	DCTN1	Homo sapiens	Q14203-5	Validated Y2H	32814053
Intra	BRK1	Q8WUW1	DCTN1	Homo sapiens	Q14203-5	Y2H Array	32814053
Intra	BRK1	Q8WUW1	BCKDK	Homo sapiens	O14874-2	Y2H Pooling	32814053
Intra	BRK1	Q8WUW1	BCKDK	Homo sapiens	O14874-2	Validated Y2H	32814053
Intra	BRK1	Q8WUW1	BCKDK	Homo sapiens	O14874-2	Y2H Array	32814053
Intra	BRK1	Q8WUW1	TUBA1B	Homo sapiens	P68363-2	Y2H Array	32814053
Intra	BRK1	Q8WUW1	TUBA1B	Homo sapiens	P68363-2	Y2H Pooling	32814053
Intra	BRK1	Q8WUW1	TUBA1B	Homo sapiens	P68363-2	Validated Y2H	32814053
Intra	BRK1	Q8WUW1	NUP58	Homo sapiens	Q9BVL2	Validated Y2H	32814053
Intra	BRK1	Q8WUW1	NUP58	Homo sapiens	Q9BVL2	Y2H Array	32814053
Intra	BRK1	Q8WUW1	NUP58	Homo sapiens	Q9BVL2	Y2H Pooling	32814053
Intra	BRK1	Q8WUW1	CDC37L1	Homo sapiens	Q7L3B6	Validated Y2H	32814053
Intra	BRK1	Q8WUW1	CDC37L1	Homo sapiens	Q7L3B6	Y2H Pooling	32814053
Intra	BRK1	Q8WUW1	CDC37L1	Homo sapiens	Q7L3B6	Y2H Array	32814053
Intra	BRK1	Q8WUW1	ZNHIT1	Homo sapiens	O43257	Validated Y2H	32814053
Intra	BRK1	Q8WUW1	ZNHIT1	Homo sapiens	O43257	Y2H Array	32814053
Intra	BRK1	Q8WUW1	ZNHIT1	Homo sapiens	O43257	Y2H Pooling	32814053
Intra	BRK1	Q8WUW1	PRMT5	Homo sapiens	O14744	Y2H Array	32814053
Intra	BRK1	Q8WUW1	PRMT5	Homo sapiens	O14744	Validated Y2H	32814053
Intra	BRK1	Q8WUW1	PRMT5	Homo sapiens	O14744	Y2H Pooling	32814053
Intra	BRK1	Q8WUW1	EEF1G	Homo sapiens	P26641	Validated Y2H	32814053
Intra	BRK1	Q8WUW1	EEF1G	Homo sapiens	P26641	Y2H Array	32814053
Intra	BRK1	Q8WUW1	EEF1G	Homo sapiens	P26641	Y2H Pooling	32814053
Intra	BRK1	Q8WUW1	VDAC2	Homo sapiens	P45880	Validated Y2H	32814053
Intra	BRK1	Q8WUW1	VDAC2	Homo sapiens	P45880	Y2H Array	32814053
Intra	BRK1	Q8WUW1	VDAC2	Homo sapiens	P45880	Y2H Pooling	32814053
Intra	BRK1	Q8WUW1	CCT6A	Homo sapiens	P40227	Y2H Pooling	32814053
Intra	BRK1	Q8WUW1	CCT6A	Homo sapiens	P40227	Validated Y2H	32814053
Intra	BRK1	Q8WUW1	CCT6A	Homo sapiens	P40227	Y2H Array	32814053
Intra	BRK1	Q8WUW1	RNF11	Homo sapiens	Q9Y3C5	Y2H Pooling	32814053
Intra	BRK1	Q8WUW1	RNF11	Homo sapiens	Q9Y3C5	Validated Y2H	32814053
Intra	BRK1	Q8WUW1	RNF11	Homo sapiens	Q9Y3C5	Y2H Array	32814053
Intra	BRK1	Q8WUW1	DTNBP1	Homo sapiens	Q96EV8	Validated Y2H	25416956
Intra	BRK1	Q8WUW1	UBE2K	Homo sapiens	P61086	Y2H Pooling	32814053
Intra	BRK1	Q8WUW1	UBE2K	Homo sapiens	P61086	Validated Y2H	32814053
Intra	BRK1	Q8WUW1	UBE2K	Homo sapiens	P61086	Y2H Array	32814053
Intra	BRK1	Q8WUW1	PMP22	Homo sapiens	A0A6Q8PF08	Validated Y2H	32814053
Intra	BRK1	Q8WUW1	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Array	32814053
Intra	BRK1	Q8WUW1	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Pooling	32814053
Intra	BRK1	Q8WUW1	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	BRK1	Q8WUW1	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	BRK1	Q8WUW1	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	BRK1	Q8WUW1	A2M	Homo sapiens	P01023	Validated Y2H	32814053
Intra	BRK1	Q8WUW1	A2M	Homo sapiens	P01023	Y2H Pooling	32814053
Intra	BRK1	Q8WUW1	A2M	Homo sapiens	P01023	Y2H Array	32814053
Intra	BRK1	Q8WUW1	MAGEB6	Homo sapiens	Q8N7X4	Y2H Array	32814053
Intra	BRK1	Q8WUW1	MAGEB6	Homo sapiens	Q8N7X4	Y2H Pooling	32814053
Intra	BRK1	Q8WUW1	MAGEB6	Homo sapiens	Q8N7X4	Validated Y2H	32814053
Intra	BRK1	Q8WUW1	NDUFV2	Homo sapiens	P19404	Y2H Array	32814053
Intra	BRK1	Q8WUW1	NDUFV2	Homo sapiens	P19404	Y2H Pooling	32814053
Intra	BRK1	Q8WUW1	NDUFV2	Homo sapiens	P19404	Validated Y2H	32814053
Intra	BRK1	Q8WUW1	CFAP68	Homo sapiens	Q9H5F2	Validated Y2H	32814053
Intra	BRK1	Q8WUW1	CFAP68	Homo sapiens	Q9H5F2	Y2H Pooling	32814053
Intra	BRK1	Q8WUW1	CFAP68	Homo sapiens	Q9H5F2	Y2H Array	32814053
Intra	BRK1	Q8WUW1	MPC2	Homo sapiens	O95563	Validated Y2H	32814053
Intra	BRK1	Q8WUW1	MPC2	Homo sapiens	O95563	Y2H Array	32814053
Intra	BRK1	Q8WUW1	MPC2	Homo sapiens	O95563	Y2H Pooling	32814053
Intra	BRK1	Q8WUW1	LAPTM4A	Homo sapiens	Q15012	Validated Y2H	32814053
Intra	BRK1	Q8WUW1	LAPTM4A	Homo sapiens	Q15012	Y2H Array	32814053
Intra	BRK1	Q8WUW1	LAPTM4A	Homo sapiens	Q15012	Y2H Pooling	32814053
Intra	BRK1	Q8WUW1	BRME1	Homo sapiens	Q0VDD7	Validated Y2H	32814053
Intra	BRK1	Q8WUW1	BRME1	Homo sapiens	Q0VDD7	Y2H Array	32814053
Intra	BRK1	Q8WUW1	BRME1	Homo sapiens	Q0VDD7	Y2H Pooling	32814053
Intra	BRK1	Q8WUW1	GFAP	Homo sapiens	P14136	Validated Y2H	32814053
Intra	BRK1	Q8WUW1	GFAP	Homo sapiens	P14136	Y2H Array	32814053
Intra	BRK1	Q8WUW1	GFAP	Homo sapiens	P14136	Y2H Pooling	32814053
Intra	BRK1	Q8WUW1	NME4	Homo sapiens	O00746	Y2H Pooling	32814053
Intra	BRK1	Q8WUW1	NME4	Homo sapiens	O00746	Validated Y2H	32814053
Intra	BRK1	Q8WUW1	NME4	Homo sapiens	O00746	Y2H Array	32814053
Intra	BRK1	Q8WUW1	HSBP1	Homo sapiens	O75506	Anti Tag CoIP	33961781
Intra	BRK1	Q8WUW1	HSBP1	Homo sapiens	O75506	Y2H Prey Pooling	32296183
Intra	BRK1	Q8WUW1	HSBP1	Homo sapiens	O75506	Y2H Array	32296183
Intra	BRK1	Q8WUW1	PRPH	Homo sapiens	P41219	Validated Y2H	32814053
Intra	BRK1	Q8WUW1	PRPH	Homo sapiens	P41219	Y2H Array	32814053
Intra	BRK1	Q8WUW1	PRPH	Homo sapiens	P41219	Y2H Pooling	32814053
Intra	BRK1	Q8WUW1	RYBP	Homo sapiens	Q8N488	Y2H Array	32814053
Intra	BRK1	Q8WUW1	RYBP	Homo sapiens	Q8N488	Validated Y2H	32814053
Intra	BRK1	Q8WUW1	RYBP	Homo sapiens	Q8N488	Y2H Pooling	32814053
Intra	BRK1	Q8WUW1	SPPL2B	Homo sapiens	Q8TCT7-2	Validated Y2H	32814053
Intra	BRK1	Q8WUW1	SPPL2B	Homo sapiens	Q8TCT7-2	Y2H Array	32814053
Intra	BRK1	Q8WUW1	SPPL2B	Homo sapiens	Q8TCT7-2	Y2H Pooling	32814053
Intra	BRK1	Q8WUW1	DBH	Homo sapiens	P09172	Y2H Array	32814053
Intra	BRK1	Q8WUW1	DBH	Homo sapiens	P09172	Y2H Pooling	32814053
Intra	BRK1	Q8WUW1	DBH	Homo sapiens	P09172	Validated Y2H	32814053
Intra	BRK1	Q8WUW1	P2RY2	Homo sapiens	P41231	Y2H Array	32814053
Intra	BRK1	Q8WUW1	P2RY2	Homo sapiens	P41231	Validated Y2H	32814053
Intra	BRK1	Q8WUW1	P2RY2	Homo sapiens	P41231	Y2H Pooling	32814053
Intra	BRK1	Q8WUW1	IFT20	Homo sapiens	Q8IY31-3	Y2H Array	32814053
Intra	BRK1	Q8WUW1	IFT20	Homo sapiens	Q8IY31-3	Y2H Pooling	32814053
Intra	BRK1	Q8WUW1	IFT20	Homo sapiens	Q8IY31-3	Validated Y2H	32814053
Intra	BRK1	Q8WUW1	NDEL1	Homo sapiens	Q9GZM8	Y2H Array	32814053
Intra	BRK1	Q8WUW1	NDEL1	Homo sapiens	Q9GZM8	Validated Y2H	32296183
Intra	BRK1	Q8WUW1	NDEL1	Homo sapiens	Q9GZM8	Anti Tag CoIP	33961781
Intra	BRK1	Q8WUW1	NDEL1	Homo sapiens	Q9GZM8	Y2H Array	32296183
Intra	BRK1	Q8WUW1	NDEL1	Homo sapiens	Q9GZM8	Y2H Pooling	32814053
Intra	BRK1	Q8WUW1	NDEL1	Homo sapiens	Q9GZM8	Y2H Prey Pooling	32296183
Intra	BRK1	Q8WUW1	NDEL1	Homo sapiens	Q9GZM8	Validated Y2H	32814053
Intra	BRK1	Q8WUW1	MRFAP1	Homo sapiens	Q9Y605	Validated Y2H	32814053
Intra	BRK1	Q8WUW1	MRFAP1	Homo sapiens	Q9Y605	Y2H Pooling	32814053
Intra	BRK1	Q8WUW1	MRFAP1	Homo sapiens	Q9Y605	Y2H Array	32814053
Intra	BRK1	Q8WUW1	MRFAP1	Homo sapiens	Q9Y605	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Hemangioma Of Lung

Pulmonary Hemangioma

Retinal Hemangioblastoma

Capillary Hemangioma Of Retina

Cardiac Tamponade

Pericardial Tamponade

Rose'S Tamponade

Patent Foramen Ovale

Atrial Septal Defect Within Oval Fossa	Foramen Ovale Patent
Ostium Secundum Atrial Septal Defect	Atrial Septal Defect, Ostium Secundum Type
Foramen Ovale, Patent	Defect, Patent Or Persistent, Ostium Secundum
Ostium Secundum Type Atrial Septal Defect	Persistent Ostium Secundum
Asd Ostium Secundum Type	Ostium Secundum Asd
Osasd	Asd, Ostium Secundum Type
Pfo - [Patent Foramen Ovale]	Open Foramen Ovale
Open Oval Foramen	Persistent Foramen Ovale
Secundum Atrial Septal Defect

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01625	BRK1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	BRK1	MGD	MGI:1915406
Macaca mulatta	BRK1	VGNC	VGNC:110380
Bos taurus	BRK1	VGNC	VGNC:26570
Felis catus	BRK1	VGNC	VGNC:69361
Rattus norvegicus	BRK1	RGD	RGD:1598136
Canis familiaris	BRK1	VGNC	VGNC:54277

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