2. Gene
  3. YES1 - YES proto-oncogene 1, Src family tyrosine kinase Gene

YES1 - YES proto-oncogene 1, Src family tyrosine kinase Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as Yes; c-yes; HsT441; P61-YES

Gene ID: 7525 | Gene type: protein coding

About YES1

Cytogenetic location: 18p11.32 Genomic coordinates (GRCh38): 18:721,588-812,753 (from NCBI)

This gene has 5 transcripts (splice variants), 261 orthologues and 32 paralogues. Ubiquitous expression in placenta (RPKM 22.4), fat (RPKM 16.6) and 25 other tissues.

Summary

This gene is the cellular homolog of the Yamaguchi sarcoma virus oncogene. The encoded protein has tyrosine kinase activity and belongs to the Src family of proteins. This gene lies in close proximity to Thymidylate Synthase gene on chromosome 18, and a corresponding pseudogene has been found on chromosome 22. [provided by RefSeq, Jul 2008]

YES1 Products(1)

mRNA Protein Name
NM_005433.4 NP_005424.1 tyrosine-protein kinase Yes
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables enzyme binding IPI
IPI: Inferred from physical interaction
20605918 GOA
enables phosphotyrosine residue binding IPI
IPI: Inferred from physical interaction
20624904 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
15657067 GOA
enables protein tyrosine kinase activity EXP
EXP: Inferred from Experiment
1381360 GOA
enables protein tyrosine kinase activity IDA
IDA: Inferred from direct assay
26979622 GOA
enables transmembrane transporter binding IPI
IPI: Inferred from physical interaction
12538589 GOA
Cellular Component GO Annotation Evidence Reference Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
20605918 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
20605918 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

YES1 Protein Structure

SH3_1

SH3_1: SH3 domain (97 - 144)

SH2

SH2: SH2 domain (158 - 240)

Pkinase_Tyr

Pkinase_Tyr: Protein tyrosine kinase (278 - 526)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 543 a.a.
Protein Preferred Names Protein Names

tyrosine-protein kinase Yes

YES1 proto-oncogene, Src family tyrosine kinase

YES1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
YES1 P07947 PTK2 Homo sapiens I6L996
Y2H Array
32296183
Intra
YES1 P07947 PTK2 Homo sapiens I6L996
Y2H Prey Pooling
32296183
Intra
YES1 P07947 CDCP1 Homo sapiens Q9H5V8
Anti Bait CoIP
21725358
Intra
YES1 P07947 TSGA10IP Homo sapiens Q3SY00
Validated Y2H
32296183
Intra
YES1 P07947 TSGA10IP Homo sapiens Q3SY00
Y2H Array
32296183
Intra
YES1 P07947 TSGA10IP Homo sapiens Q3SY00
Y2H Prey Pooling
32296183
Intra
YES1 P07947 MET Homo sapiens P08581
FPS
24728074
Intra
YES1 P07947 DOK2 Homo sapiens O60496
Y2H Array
32296183
Intra
YES1 P07947 DOK2 Homo sapiens O60496
Y2H Prey Pooling
32296183
Intra
YES1 P07947 GAS8 Homo sapiens O95995
Y2H Array
32296183
Intra
YES1 P07947 GAS8 Homo sapiens O95995
Y2H Prey Pooling
32296183
Intra
YES1 P07947 DES Homo sapiens P17661
Validated Y2H
32296183
Intra
YES1 P07947 DES Homo sapiens P17661
Y2H Array
32296183
Intra
YES1 P07947 DES Homo sapiens P17661
Y2H Prey Pooling
32296183
Intra
YES1 P07947 CHMP1A Homo sapiens Q9HD42
Y2H Prey Pooling
32296183
Intra
YES1 P07947 CHMP1A Homo sapiens Q9HD42
Validated Y2H
32296183
Intra
YES1 P07947 CHMP1A Homo sapiens Q9HD42
Y2H Array
32296183
Intra
YES1 P07947 FXR1 Homo sapiens P51114-2
Validated Y2H
32296183
Intra
YES1 P07947 FXR1 Homo sapiens P51114-2
Y2H Array
32296183
Intra
YES1 P07947 FXR1 Homo sapiens P51114-2
Y2H Prey Pooling
32296183
Intra
YES1 P07947 CEP57L1 Homo sapiens Q8IYX8
Y2H Prey Pooling
32296183
Intra
YES1 P07947 CEP57L1 Homo sapiens Q8IYX8
Validated Y2H
32296183
Intra
YES1 P07947 CEP57L1 Homo sapiens Q8IYX8
Y2H Array
32296183
Intra
YES1 P07947 CPSF6 Homo sapiens Q16630-2
Validated Y2H
32296183
Intra
YES1 P07947 CPSF6 Homo sapiens Q16630-2
Y2H Array
32296183
Intra
YES1 P07947 CPSF6 Homo sapiens Q16630-2
Y2H Prey Pooling
32296183
Intra
YES1 P07947 CEP83 Homo sapiens Q9Y592-2
Y2H Prey Pooling
32296183
Intra
YES1 P07947 CEP83 Homo sapiens Q9Y592-2
Validated Y2H
32296183
Intra
YES1 P07947 CEP83 Homo sapiens Q9Y592-2
Y2H Array
32296183
Intra
YES1 P07947 EFS Homo sapiens O43281-2
Y2H Array
32296183
Intra
YES1 P07947 EFS Homo sapiens O43281-2
Y2H Prey Pooling
32296183
Intra
YES1 P07947 CARD9 Homo sapiens Q9H257-2
Validated Y2H
32296183
Intra
YES1 P07947 CARD9 Homo sapiens Q9H257-2
Y2H Array
32296183
Intra
YES1 P07947 CARD9 Homo sapiens Q9H257-2
Y2H Prey Pooling
32296183
Intra
YES1 P07947 FLACC1 Homo sapiens Q96Q35-2
Validated Y2H
32296183
Intra
YES1 P07947 FLACC1 Homo sapiens Q96Q35-2
Y2H Prey Pooling
32296183
Intra
YES1 P07947 FLACC1 Homo sapiens Q96Q35-2
Y2H Array
32296183
Intra
YES1 P07947 LIN7C Homo sapiens Q9NUP9
Y2H Prey Pooling
32296183
Intra
YES1 P07947 LIN7C Homo sapiens Q9NUP9
Y2H Array
32296183
Intra
YES1 P07947 LIN7C Homo sapiens Q9NUP9
Validated Y2H
32296183
Intra
YES1 P07947 PXN Homo sapiens P49023-2
Y2H Array
32296183
Intra
YES1 P07947 PXN Homo sapiens P49023-2
Validated Y2H
32296183
Intra
YES1 P07947 PXN Homo sapiens P49023-2
Y2H Prey Pooling
32296183
Intra
YES1 P07947 ZNF438 Homo sapiens Q7Z4V0
Y2H Array
32296183
Intra
YES1 P07947 ZNF438 Homo sapiens Q7Z4V0
Y2H Prey Pooling
32296183
Intra
YES1 P07947 ZNF438 Homo sapiens Q7Z4V0
Validated Y2H
32296183
Intra
YES1 P07947 BICD2 Homo sapiens Q8TD16-2
Validated Y2H
32296183
Intra
YES1 P07947 BICD2 Homo sapiens Q8TD16-2
Y2H Prey Pooling
32296183
Intra
YES1 P07947 BICD2 Homo sapiens Q8TD16-2
Y2H Array
32296183
Intra
YES1 P07947 TRIM5 Homo sapiens Q9C035-3
Y2H Prey Pooling
32296183
Intra
YES1 P07947 TRIM5 Homo sapiens Q9C035-3
Validated Y2H
32296183
Intra
YES1 P07947 TRIM5 Homo sapiens Q9C035-3
Y2H Array
32296183
Intra
YES1 P07947 DENND2C Homo sapiens Q68D51-2
Y2H Prey Pooling
32296183
Intra
YES1 P07947 DENND2C Homo sapiens Q68D51-2
Validated Y2H
32296183
Intra
YES1 P07947 DENND2C Homo sapiens Q68D51-2
Y2H Array
32296183
Intra
YES1 P07947 KIT Homo sapiens P10721
FPS
24728074
Intra
YES1 P07947 SOCS7 Homo sapiens O14512
Y2H Array
32296183
Intra
YES1 P07947 SOCS7 Homo sapiens O14512
Y2H Prey Pooling
32296183
Intra
YES1 P07947 STAP2 Homo sapiens Q9UGK3
Validated Y2H
32296183
Intra
YES1 P07947 STAP2 Homo sapiens Q9UGK3
Y2H Array
32296183
Intra
YES1 P07947 STAP2 Homo sapiens Q9UGK3
Y2H Prey Pooling
32296183
Intra
YES1 P07947 DTX3 Homo sapiens Q8N9I9
Validated Y2H
32296183
Intra
YES1 P07947 DTX3 Homo sapiens Q8N9I9
Y2H Array
32296183
Intra
YES1 P07947 DTX3 Homo sapiens Q8N9I9
Y2H Prey Pooling
32296183
Intra
YES1 P07947 CBLC Homo sapiens Q9ULV8
Validated Y2H
32296183
Intra
YES1 P07947 CBLC Homo sapiens Q9ULV8
Y2H Array
32296183
Intra
YES1 P07947 CBLC Homo sapiens Q9ULV8
Y2H Prey Pooling
32296183
Intra
YES1 P07947 SF3A2 Homo sapiens Q15428
Y2H Prey Pooling
32296183
Intra
YES1 P07947 SF3A2 Homo sapiens Q15428
Validated Y2H
32296183
Intra
YES1 P07947 SF3A2 Homo sapiens Q15428
Y2H Array
32296183
Intra
YES1 P07947 JAKMIP1 Homo sapiens Q96N16
Y2H Prey Pooling
32296183
Intra
YES1 P07947 JAKMIP1 Homo sapiens Q96N16
Validated Y2H
32296183
Intra
YES1 P07947 JAKMIP1 Homo sapiens Q96N16
Y2H Array
32296183
Intra
YES1 P07947 SSBP3 Homo sapiens Q9BWW4
Validated Y2H
32296183
Intra
YES1 P07947 SSBP3 Homo sapiens Q9BWW4
Y2H Array
32296183
Intra
YES1 P07947 SSBP3 Homo sapiens Q9BWW4
Y2H Prey Pooling
25416956
Intra
YES1 P07947 SSBP3 Homo sapiens Q9BWW4
Y2H Prey Pooling
32296183
Intra
YES1 P07947 SSBP3 Homo sapiens Q9BWW4
Validated Y2H
25416956
Intra
YES1 P07947 CDC37 Homo sapiens Q16543
Anti Tag CoIP
31980649
Intra
YES1 P07947 CDC37 Homo sapiens Q16543
Anti Tag CoIP
33961781
Intra
YES1 P07947 CDC37 Homo sapiens Q16543
Anti Tag CoIP
28514442
Intra
YES1 P07947 EGFR Homo sapiens P00533
Anti Bait CoIP
23866081
Intra
YES1 P07947 FUNDC1 Homo sapiens Q8IVP5
Validated Y2H
25416956
Intra
YES1 P07947 FUNDC1 Homo sapiens Q8IVP5
Y2H Array
25416956
Intra
YES1 P07947 HSP90AB1 Homo sapiens P08238
Anti Tag CoIP
31980649
Intra
YES1 P07947 TRAF2 Homo sapiens Q12933
Validated Y2H
25416956
Intra
YES1 P07947 TRAF2 Homo sapiens Q12933
Y2H Prey Pooling
32296183
Intra
YES1 P07947 TRAF2 Homo sapiens Q12933
Validated Y2H
32296183
Intra
YES1 P07947 TRAF2 Homo sapiens Q12933
Y2H Array
25416956
Intra
YES1 P07947 TRAF2 Homo sapiens Q12933
Y2H Array
32296183
Intra
YES1 P07947 TRAF2 Homo sapiens Q12933
Y2H Prey Pooling
25416956
Intra
YES1 P07947 TRAF6 Homo sapiens Q9Y4K3
Y2H Prey Pooling
32296183
Intra
YES1 P07947 TRAF6 Homo sapiens Q9Y4K3
Validated Y2H
32296183
Intra
YES1 P07947 TRAF6 Homo sapiens Q9Y4K3
Y2H Array
32296183
Intra
YES1 P07947 TRAF6 Homo sapiens Q9Y4K3
Y2H Prey Pooling
25416956
Intra
YES1 P07947 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
Intra
YES1 P07947 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
Intra
YES1 P07947 OLIG1 Homo sapiens Q8TAK6
Lumier
25814554
Intra
YES1 P07947 MED28 Homo sapiens Q9H204
Peptide Array
16964398
Intra
YES1 P07947 GAB1 Homo sapiens Q13480
FPS
24728074
Intra
YES1 P07947 ZC2HC1A Homo sapiens Q96GY0
Validated Y2H
32296183
Intra
YES1 P07947 ZC2HC1A Homo sapiens Q96GY0
Y2H Array
32296183
Intra
YES1 P07947 ZC2HC1A Homo sapiens Q96GY0
Y2H Prey Pooling
32296183
Intra
YES1 P07947 AR Homo sapiens P10275
FPS
24728074
Intra
YES1 P07947 SOCS2 Homo sapiens O14508
Y2H Prey Pooling
32296183
Intra
YES1 P07947 SOCS2 Homo sapiens O14508
Y2H Array
32296183
Intra
YES1 P07947 BCAR1 Homo sapiens P56945
Validated Y2H
32296183
Intra
YES1 P07947 BCAR1 Homo sapiens P56945
Y2H Array
32296183
Intra
YES1 P07947 BCAR1 Homo sapiens P56945
Y2H Prey Pooling
32296183
Intra
YES1 P07947 SOCS3 Homo sapiens O14543
Y2H Array
25416956
Intra
YES1 P07947 SOCS3 Homo sapiens O14543
Y2H Prey Pooling
25416956
Intra
YES1 P07947 FXR2 Homo sapiens P51116
Y2H Array
25416956
Intra
YES1 P07947 FXR2 Homo sapiens P51116
Y2H Array
32296183
Intra
YES1 P07947 FXR2 Homo sapiens P51116
Validated Y2H
32296183
Intra
YES1 P07947 FXR2 Homo sapiens P51116
Validated Y2H
25416956
Intra
YES1 P07947 FXR2 Homo sapiens P51116
Y2H Prey Pooling
25416956
Intra
YES1 P07947 FXR2 Homo sapiens P51116
Y2H Prey Pooling
32296183
Intra
YES1 P07947 NIF3L1 Homo sapiens Q9GZT8
Validated Y2H
25416956
Intra
YES1 P07947 NIF3L1 Homo sapiens Q9GZT8
Y2H Array
25416956
Intra
YES1 P07947 THAP1 Homo sapiens Q9NVV9
Validated Y2H
32296183
Intra
YES1 P07947 THAP1 Homo sapiens Q9NVV9
Y2H Array
25416956
Intra
YES1 P07947 THAP1 Homo sapiens Q9NVV9
Y2H Array
32296183
Intra
YES1 P07947 THAP1 Homo sapiens Q9NVV9
Y2H Prey Pooling
25416956
Intra
YES1 P07947 DDIT4L Homo sapiens Q96D03
Validated Y2H
32296183
Intra
YES1 P07947 DDIT4L Homo sapiens Q96D03
Y2H Array
32296183
Intra
YES1 P07947 DDIT4L Homo sapiens Q96D03
Y2H Prey Pooling
32296183
Intra
YES1 P07947 ZBTB8A Homo sapiens Q96BR9
Validated Y2H
25416956
Intra
YES1 P07947 ZBTB8A Homo sapiens Q96BR9
Y2H Prey Pooling
32296183
Intra
YES1 P07947 ZBTB8A Homo sapiens Q96BR9
Validated Y2H
32296183
Intra
YES1 P07947 ZBTB8A Homo sapiens Q96BR9
Y2H Array
25416956
Intra
YES1 P07947 ZBTB8A Homo sapiens Q96BR9
Y2H Array
32296183
Intra
YES1 P07947 ZBTB8A Homo sapiens Q96BR9
Y2H Prey Pooling
25416956
Intra
YES1 P07947 CBLB Homo sapiens Q13191
Validated Y2H
32296183
Intra
YES1 P07947 CBLB Homo sapiens Q13191
Y2H Prey Pooling
32296183
Intra
YES1 P07947 CBLB Homo sapiens Q13191
Y2H Array
32296183
Intra
YES1 P07947 GFAP Homo sapiens P14136
Validated Y2H
32296183
Intra
YES1 P07947 GFAP Homo sapiens P14136
Y2H Prey Pooling
32296183
Intra
YES1 P07947 GFAP Homo sapiens P14136
Y2H Array
32296183
Intra
YES1 P07947 AMOTL2 Homo sapiens Q9Y2J4
Validated Y2H
32296183
Intra
YES1 P07947 AMOTL2 Homo sapiens Q9Y2J4
Y2H Array
32296183
Intra
YES1 P07947 AMOTL2 Homo sapiens Q9Y2J4
Y2H Prey Pooling
32296183
Intra
YES1 P07947 IKZF3 Homo sapiens Q9UKT9
Validated Y2H
32296183
Intra
YES1 P07947 IKZF3 Homo sapiens Q9UKT9
Y2H Array
32296183
Intra
YES1 P07947 IKZF3 Homo sapiens Q9UKT9
Y2H Prey Pooling
32296183
Intra
YES1 P07947 SH3GLB2 Homo sapiens Q9NR46
Y2H Prey Pooling
32296183
Intra
YES1 P07947 SH3GLB2 Homo sapiens Q9NR46
Validated Y2H
32296183
Intra
YES1 P07947 SH3GLB2 Homo sapiens Q9NR46
Y2H Array
32296183
Intra
YES1 P07947 PICK1 Homo sapiens Q9NRD5
Validated Y2H
32296183
Intra
YES1 P07947 PICK1 Homo sapiens Q9NRD5
Y2H Prey Pooling
32296183
Intra
YES1 P07947 PICK1 Homo sapiens Q9NRD5
Y2H Array
32296183
Intra
YES1 P07947 PIK3R3 Homo sapiens Q92569
Y2H Prey Pooling
32296183
Intra
YES1 P07947 PIK3R3 Homo sapiens Q92569
Validated Y2H
32296183
Intra
YES1 P07947 PIK3R3 Homo sapiens Q92569
Y2H Array
32296183
Intra
YES1 P07947 LASP1 Homo sapiens Q14847-2
Y2H Array
32296183
Intra
YES1 P07947 LASP1 Homo sapiens Q14847-2
Validated Y2H
32296183
Intra
YES1 P07947 LASP1 Homo sapiens Q14847-2
Y2H Prey Pooling
32296183
Intra
YES1 P07947 CRKL Homo sapiens P46109
Y2H Prey Pooling
32296183
Intra
YES1 P07947 CRKL Homo sapiens P46109
Y2H Array
32296183
Intra
YES1 P07947 CRKL Homo sapiens P46109
Validated Y2H
32296183
Intra
YES1 P07947 C1orf94 Homo sapiens Q6P1W5
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant YES1 Proteins

Cat. No. Product Name Accession Purity
HY-P73486 YES1 Protein, Human (sf9, His-GST) P07947 (G2-L543) ≥95%

Related Diseases

Diseases Alias
Sarcoma

Connective And Soft Tissue Neoplasm

Tumor Of Soft Tissue And Skeleton

Sarcomas

Sarcoma - Category
Co-Trimoxazole Allergy

Bactrim Allergy

Cotrimoxazol Allergy

Tmp/Smx Allergy

Trimethoprim/Sulfamethoxazole Allergy
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon
Thrombocytopenia

Low Platelet Count

Low Platelets

Decreased Platelets

Platelet Dysfunction Nos
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-136848 SM1-71 Inhibitor 96.09% Unkown
HY-135299 CH6953755 Inhibitor 99.45% Unkown
HY-145373 BMS-986143 Inhibitor / Unkown
HY-E70293 N-Acetylgalactosaminyltransferase 12 / Unkown
HY-RS15922 YES1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus YES1 RGD RGD:3977
Bos taurus YES1 VGNC VGNC:37022
Canis familiaris YES1 VGNC VGNC:48484
Mus musculus YES1 MGD MGI:99147
Macaca mulatta YES1 VGNC VGNC:78817
Felis catus YES1 VGNC VGNC:67136
Others YES1 NCBI