YES1 - YES proto-oncogene 1, Src family tyrosine kinase Gene

Homo sapiens

Also known as Yes; c-yes; HsT441; P61-YES

Gene ID: 7525 | Gene type: protein coding

About YES1

Cytogenetic location: 18p11.32 Genomic coordinates (GRCh38): 18:721,588-812,753 (from NCBI)

This gene has 5 transcripts (splice variants), 261 orthologues and 32 paralogues. Ubiquitous expression in placenta (RPKM 22.4), fat (RPKM 16.6) and 25 other tissues.

Summary

This gene is the cellular homolog of the Yamaguchi sarcoma virus oncogene. The encoded protein has tyrosine kinase activity and belongs to the Src family of proteins. This gene lies in close proximity to Thymidylate Synthase gene on chromosome 18, and a corresponding pseudogene has been found on chromosome 22. [provided by RefSeq, Jul 2008]

YES1 Products(1)

mRNA	Protein	Name
NM_005433.4	NP_005424.1	tyrosine-protein kinase Yes

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables enzyme binding	IPI IPI: Inferred from physical interaction	20605918	GOA
enables phosphotyrosine residue binding	IPI IPI: Inferred from physical interaction	20624904	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15657067	GOA
enables protein tyrosine kinase activity	EXP EXP: Inferred from Experiment	1381360	GOA
enables protein tyrosine kinase activity	IDA IDA: Inferred from direct assay	26979622	GOA
enables transmembrane transporter binding	IPI IPI: Inferred from physical interaction	12538589	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	20605918	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	20605918	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

YES1 Protein Structure

SH3_1

SH2

Pkinase_Tyr

0
100
200
300
400
500
543 a.a.

Protein Preferred Names

Protein Names

tyrosine-protein kinase Yes

YES1 proto-oncogene, Src family tyrosine kinase

YES1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	YES1	P07947	PTK2	Homo sapiens	I6L996	Y2H Array	32296183
Intra	YES1	P07947	PTK2	Homo sapiens	I6L996	Y2H Prey Pooling	32296183
Intra	YES1	P07947	CDCP1	Homo sapiens	Q9H5V8	Anti Bait CoIP	21725358
Intra	YES1	P07947	TSGA10IP	Homo sapiens	Q3SY00	Validated Y2H	32296183
Intra	YES1	P07947	TSGA10IP	Homo sapiens	Q3SY00	Y2H Array	32296183
Intra	YES1	P07947	TSGA10IP	Homo sapiens	Q3SY00	Y2H Prey Pooling	32296183
Intra	YES1	P07947	MET	Homo sapiens	P08581	FPS	24728074
Intra	YES1	P07947	DOK2	Homo sapiens	O60496	Y2H Array	32296183
Intra	YES1	P07947	DOK2	Homo sapiens	O60496	Y2H Prey Pooling	32296183
Intra	YES1	P07947	GAS8	Homo sapiens	O95995	Y2H Array	32296183
Intra	YES1	P07947	GAS8	Homo sapiens	O95995	Y2H Prey Pooling	32296183
Intra	YES1	P07947	DES	Homo sapiens	P17661	Validated Y2H	32296183
Intra	YES1	P07947	DES	Homo sapiens	P17661	Y2H Array	32296183
Intra	YES1	P07947	DES	Homo sapiens	P17661	Y2H Prey Pooling	32296183
Intra	YES1	P07947	CHMP1A	Homo sapiens	Q9HD42	Y2H Prey Pooling	32296183
Intra	YES1	P07947	CHMP1A	Homo sapiens	Q9HD42	Validated Y2H	32296183
Intra	YES1	P07947	CHMP1A	Homo sapiens	Q9HD42	Y2H Array	32296183
Intra	YES1	P07947	FXR1	Homo sapiens	P51114-2	Validated Y2H	32296183
Intra	YES1	P07947	FXR1	Homo sapiens	P51114-2	Y2H Array	32296183
Intra	YES1	P07947	FXR1	Homo sapiens	P51114-2	Y2H Prey Pooling	32296183
Intra	YES1	P07947	CEP57L1	Homo sapiens	Q8IYX8	Y2H Prey Pooling	32296183
Intra	YES1	P07947	CEP57L1	Homo sapiens	Q8IYX8	Validated Y2H	32296183
Intra	YES1	P07947	CEP57L1	Homo sapiens	Q8IYX8	Y2H Array	32296183
Intra	YES1	P07947	CPSF6	Homo sapiens	Q16630-2	Validated Y2H	32296183
Intra	YES1	P07947	CPSF6	Homo sapiens	Q16630-2	Y2H Array	32296183
Intra	YES1	P07947	CPSF6	Homo sapiens	Q16630-2	Y2H Prey Pooling	32296183
Intra	YES1	P07947	CEP83	Homo sapiens	Q9Y592-2	Y2H Prey Pooling	32296183
Intra	YES1	P07947	CEP83	Homo sapiens	Q9Y592-2	Validated Y2H	32296183
Intra	YES1	P07947	CEP83	Homo sapiens	Q9Y592-2	Y2H Array	32296183
Intra	YES1	P07947	EFS	Homo sapiens	O43281-2	Y2H Array	32296183
Intra	YES1	P07947	EFS	Homo sapiens	O43281-2	Y2H Prey Pooling	32296183
Intra	YES1	P07947	CARD9	Homo sapiens	Q9H257-2	Validated Y2H	32296183
Intra	YES1	P07947	CARD9	Homo sapiens	Q9H257-2	Y2H Array	32296183
Intra	YES1	P07947	CARD9	Homo sapiens	Q9H257-2	Y2H Prey Pooling	32296183
Intra	YES1	P07947	FLACC1	Homo sapiens	Q96Q35-2	Validated Y2H	32296183
Intra	YES1	P07947	FLACC1	Homo sapiens	Q96Q35-2	Y2H Prey Pooling	32296183
Intra	YES1	P07947	FLACC1	Homo sapiens	Q96Q35-2	Y2H Array	32296183
Intra	YES1	P07947	LIN7C	Homo sapiens	Q9NUP9	Y2H Prey Pooling	32296183
Intra	YES1	P07947	LIN7C	Homo sapiens	Q9NUP9	Y2H Array	32296183
Intra	YES1	P07947	LIN7C	Homo sapiens	Q9NUP9	Validated Y2H	32296183
Intra	YES1	P07947	PXN	Homo sapiens	P49023-2	Y2H Array	32296183
Intra	YES1	P07947	PXN	Homo sapiens	P49023-2	Validated Y2H	32296183
Intra	YES1	P07947	PXN	Homo sapiens	P49023-2	Y2H Prey Pooling	32296183
Intra	YES1	P07947	ZNF438	Homo sapiens	Q7Z4V0	Y2H Array	32296183
Intra	YES1	P07947	ZNF438	Homo sapiens	Q7Z4V0	Y2H Prey Pooling	32296183
Intra	YES1	P07947	ZNF438	Homo sapiens	Q7Z4V0	Validated Y2H	32296183
Intra	YES1	P07947	BICD2	Homo sapiens	Q8TD16-2	Validated Y2H	32296183
Intra	YES1	P07947	BICD2	Homo sapiens	Q8TD16-2	Y2H Prey Pooling	32296183
Intra	YES1	P07947	BICD2	Homo sapiens	Q8TD16-2	Y2H Array	32296183
Intra	YES1	P07947	TRIM5	Homo sapiens	Q9C035-3	Y2H Prey Pooling	32296183
Intra	YES1	P07947	TRIM5	Homo sapiens	Q9C035-3	Validated Y2H	32296183
Intra	YES1	P07947	TRIM5	Homo sapiens	Q9C035-3	Y2H Array	32296183
Intra	YES1	P07947	DENND2C	Homo sapiens	Q68D51-2	Y2H Prey Pooling	32296183
Intra	YES1	P07947	DENND2C	Homo sapiens	Q68D51-2	Validated Y2H	32296183
Intra	YES1	P07947	DENND2C	Homo sapiens	Q68D51-2	Y2H Array	32296183
Intra	YES1	P07947	KIT	Homo sapiens	P10721	FPS	24728074
Intra	YES1	P07947	SOCS7	Homo sapiens	O14512	Y2H Array	32296183
Intra	YES1	P07947	SOCS7	Homo sapiens	O14512	Y2H Prey Pooling	32296183
Intra	YES1	P07947	STAP2	Homo sapiens	Q9UGK3	Validated Y2H	32296183
Intra	YES1	P07947	STAP2	Homo sapiens	Q9UGK3	Y2H Array	32296183
Intra	YES1	P07947	STAP2	Homo sapiens	Q9UGK3	Y2H Prey Pooling	32296183
Intra	YES1	P07947	DTX3	Homo sapiens	Q8N9I9	Validated Y2H	32296183
Intra	YES1	P07947	DTX3	Homo sapiens	Q8N9I9	Y2H Array	32296183
Intra	YES1	P07947	DTX3	Homo sapiens	Q8N9I9	Y2H Prey Pooling	32296183
Intra	YES1	P07947	CBLC	Homo sapiens	Q9ULV8	Validated Y2H	32296183
Intra	YES1	P07947	CBLC	Homo sapiens	Q9ULV8	Y2H Array	32296183
Intra	YES1	P07947	CBLC	Homo sapiens	Q9ULV8	Y2H Prey Pooling	32296183
Intra	YES1	P07947	SF3A2	Homo sapiens	Q15428	Y2H Prey Pooling	32296183
Intra	YES1	P07947	SF3A2	Homo sapiens	Q15428	Validated Y2H	32296183
Intra	YES1	P07947	SF3A2	Homo sapiens	Q15428	Y2H Array	32296183
Intra	YES1	P07947	JAKMIP1	Homo sapiens	Q96N16	Y2H Prey Pooling	32296183
Intra	YES1	P07947	JAKMIP1	Homo sapiens	Q96N16	Validated Y2H	32296183
Intra	YES1	P07947	JAKMIP1	Homo sapiens	Q96N16	Y2H Array	32296183
Intra	YES1	P07947	SSBP3	Homo sapiens	Q9BWW4	Validated Y2H	32296183
Intra	YES1	P07947	SSBP3	Homo sapiens	Q9BWW4	Y2H Array	32296183
Intra	YES1	P07947	SSBP3	Homo sapiens	Q9BWW4	Y2H Prey Pooling	25416956
Intra	YES1	P07947	SSBP3	Homo sapiens	Q9BWW4	Y2H Prey Pooling	32296183
Intra	YES1	P07947	SSBP3	Homo sapiens	Q9BWW4	Validated Y2H	25416956
Intra	YES1	P07947	CDC37	Homo sapiens	Q16543	Anti Tag CoIP	31980649
Intra	YES1	P07947	CDC37	Homo sapiens	Q16543	Anti Tag CoIP	33961781
Intra	YES1	P07947	CDC37	Homo sapiens	Q16543	Anti Tag CoIP	28514442
Intra	YES1	P07947	EGFR	Homo sapiens	P00533	Anti Bait CoIP	23866081
Intra	YES1	P07947	FUNDC1	Homo sapiens	Q8IVP5	Validated Y2H	25416956
Intra	YES1	P07947	FUNDC1	Homo sapiens	Q8IVP5	Y2H Array	25416956
Intra	YES1	P07947	HSP90AB1	Homo sapiens	P08238	Anti Tag CoIP	31980649
Intra	YES1	P07947	TRAF2	Homo sapiens	Q12933	Validated Y2H	25416956
Intra	YES1	P07947	TRAF2	Homo sapiens	Q12933	Y2H Prey Pooling	32296183
Intra	YES1	P07947	TRAF2	Homo sapiens	Q12933	Validated Y2H	32296183
Intra	YES1	P07947	TRAF2	Homo sapiens	Q12933	Y2H Array	25416956
Intra	YES1	P07947	TRAF2	Homo sapiens	Q12933	Y2H Array	32296183
Intra	YES1	P07947	TRAF2	Homo sapiens	Q12933	Y2H Prey Pooling	25416956
Intra	YES1	P07947	TRAF6	Homo sapiens	Q9Y4K3	Y2H Prey Pooling	32296183
Intra	YES1	P07947	TRAF6	Homo sapiens	Q9Y4K3	Validated Y2H	32296183
Intra	YES1	P07947	TRAF6	Homo sapiens	Q9Y4K3	Y2H Array	32296183
Intra	YES1	P07947	TRAF6	Homo sapiens	Q9Y4K3	Y2H Prey Pooling	25416956
Intra	YES1	P07947	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183
Intra	YES1	P07947	CYSRT1	Homo sapiens	A8MQ03	Y2H Prey Pooling	32296183
Intra	YES1	P07947	OLIG1	Homo sapiens	Q8TAK6	Lumier	25814554
Intra	YES1	P07947	MED28	Homo sapiens	Q9H204	Peptide Array	16964398
Intra	YES1	P07947	GAB1	Homo sapiens	Q13480	FPS	24728074
Intra	YES1	P07947	ZC2HC1A	Homo sapiens	Q96GY0	Validated Y2H	32296183
Intra	YES1	P07947	ZC2HC1A	Homo sapiens	Q96GY0	Y2H Array	32296183
Intra	YES1	P07947	ZC2HC1A	Homo sapiens	Q96GY0	Y2H Prey Pooling	32296183
Intra	YES1	P07947	AR	Homo sapiens	P10275	FPS	24728074
Intra	YES1	P07947	SOCS2	Homo sapiens	O14508	Y2H Prey Pooling	32296183
Intra	YES1	P07947	SOCS2	Homo sapiens	O14508	Y2H Array	32296183
Intra	YES1	P07947	BCAR1	Homo sapiens	P56945	Validated Y2H	32296183
Intra	YES1	P07947	BCAR1	Homo sapiens	P56945	Y2H Array	32296183
Intra	YES1	P07947	BCAR1	Homo sapiens	P56945	Y2H Prey Pooling	32296183
Intra	YES1	P07947	SOCS3	Homo sapiens	O14543	Y2H Array	25416956
Intra	YES1	P07947	SOCS3	Homo sapiens	O14543	Y2H Prey Pooling	25416956
Intra	YES1	P07947	FXR2	Homo sapiens	P51116	Y2H Array	25416956
Intra	YES1	P07947	FXR2	Homo sapiens	P51116	Y2H Array	32296183
Intra	YES1	P07947	FXR2	Homo sapiens	P51116	Validated Y2H	32296183
Intra	YES1	P07947	FXR2	Homo sapiens	P51116	Validated Y2H	25416956
Intra	YES1	P07947	FXR2	Homo sapiens	P51116	Y2H Prey Pooling	25416956
Intra	YES1	P07947	FXR2	Homo sapiens	P51116	Y2H Prey Pooling	32296183
Intra	YES1	P07947	NIF3L1	Homo sapiens	Q9GZT8	Validated Y2H	25416956
Intra	YES1	P07947	NIF3L1	Homo sapiens	Q9GZT8	Y2H Array	25416956
Intra	YES1	P07947	THAP1	Homo sapiens	Q9NVV9	Validated Y2H	32296183
Intra	YES1	P07947	THAP1	Homo sapiens	Q9NVV9	Y2H Array	25416956
Intra	YES1	P07947	THAP1	Homo sapiens	Q9NVV9	Y2H Array	32296183
Intra	YES1	P07947	THAP1	Homo sapiens	Q9NVV9	Y2H Prey Pooling	25416956
Intra	YES1	P07947	DDIT4L	Homo sapiens	Q96D03	Validated Y2H	32296183
Intra	YES1	P07947	DDIT4L	Homo sapiens	Q96D03	Y2H Array	32296183
Intra	YES1	P07947	DDIT4L	Homo sapiens	Q96D03	Y2H Prey Pooling	32296183
Intra	YES1	P07947	ZBTB8A	Homo sapiens	Q96BR9	Validated Y2H	25416956
Intra	YES1	P07947	ZBTB8A	Homo sapiens	Q96BR9	Y2H Prey Pooling	32296183
Intra	YES1	P07947	ZBTB8A	Homo sapiens	Q96BR9	Validated Y2H	32296183
Intra	YES1	P07947	ZBTB8A	Homo sapiens	Q96BR9	Y2H Array	25416956
Intra	YES1	P07947	ZBTB8A	Homo sapiens	Q96BR9	Y2H Array	32296183
Intra	YES1	P07947	ZBTB8A	Homo sapiens	Q96BR9	Y2H Prey Pooling	25416956
Intra	YES1	P07947	CBLB	Homo sapiens	Q13191	Validated Y2H	32296183
Intra	YES1	P07947	CBLB	Homo sapiens	Q13191	Y2H Prey Pooling	32296183
Intra	YES1	P07947	CBLB	Homo sapiens	Q13191	Y2H Array	32296183
Intra	YES1	P07947	GFAP	Homo sapiens	P14136	Validated Y2H	32296183
Intra	YES1	P07947	GFAP	Homo sapiens	P14136	Y2H Prey Pooling	32296183
Intra	YES1	P07947	GFAP	Homo sapiens	P14136	Y2H Array	32296183
Intra	YES1	P07947	AMOTL2	Homo sapiens	Q9Y2J4	Validated Y2H	32296183
Intra	YES1	P07947	AMOTL2	Homo sapiens	Q9Y2J4	Y2H Array	32296183
Intra	YES1	P07947	AMOTL2	Homo sapiens	Q9Y2J4	Y2H Prey Pooling	32296183
Intra	YES1	P07947	IKZF3	Homo sapiens	Q9UKT9	Validated Y2H	32296183
Intra	YES1	P07947	IKZF3	Homo sapiens	Q9UKT9	Y2H Array	32296183
Intra	YES1	P07947	IKZF3	Homo sapiens	Q9UKT9	Y2H Prey Pooling	32296183
Intra	YES1	P07947	SH3GLB2	Homo sapiens	Q9NR46	Y2H Prey Pooling	32296183
Intra	YES1	P07947	SH3GLB2	Homo sapiens	Q9NR46	Validated Y2H	32296183
Intra	YES1	P07947	SH3GLB2	Homo sapiens	Q9NR46	Y2H Array	32296183
Intra	YES1	P07947	PICK1	Homo sapiens	Q9NRD5	Validated Y2H	32296183
Intra	YES1	P07947	PICK1	Homo sapiens	Q9NRD5	Y2H Prey Pooling	32296183
Intra	YES1	P07947	PICK1	Homo sapiens	Q9NRD5	Y2H Array	32296183
Intra	YES1	P07947	PIK3R3	Homo sapiens	Q92569	Y2H Prey Pooling	32296183
Intra	YES1	P07947	PIK3R3	Homo sapiens	Q92569	Validated Y2H	32296183
Intra	YES1	P07947	PIK3R3	Homo sapiens	Q92569	Y2H Array	32296183
Intra	YES1	P07947	LASP1	Homo sapiens	Q14847-2	Y2H Array	32296183
Intra	YES1	P07947	LASP1	Homo sapiens	Q14847-2	Validated Y2H	32296183
Intra	YES1	P07947	LASP1	Homo sapiens	Q14847-2	Y2H Prey Pooling	32296183
Intra	YES1	P07947	CRKL	Homo sapiens	P46109	Y2H Prey Pooling	32296183
Intra	YES1	P07947	CRKL	Homo sapiens	P46109	Y2H Array	32296183
Intra	YES1	P07947	CRKL	Homo sapiens	P46109	Validated Y2H	32296183
Intra	YES1	P07947	C1orf94	Homo sapiens	Q6P1W5	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant YES1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73486	YES1 Protein, Human (sf9, His-GST)	P07947 (G2-L543)	≥95%

YES1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82152	Yes1 Antibody (YA1897)	WB, IHC-P, ICC/IF, IP	Human, Mouse, Rat

Related Diseases

Diseases

Alias

Sarcoma

Connective And Soft Tissue Neoplasm	Tumor Of Soft Tissue And Skeleton
Sarcomas	Sarcoma - Category

Co-Trimoxazole Allergy

Bactrim Allergy	Cotrimoxazol Allergy
Tmp/Smx Allergy	Trimethoprim/Sulfamethoxazole Allergy

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Thrombocytopenia

Low Platelet Count	Low Platelets
Decreased Platelets	Platelet Dysfunction Nos

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-136848	SM1-71	Inhibitor	96.09%	Unkown
HY-135299	CH6953755	Inhibitor	99.45%	Unkown
HY-145373	BMS-986143	Inhibitor	/	Unkown
HY-E70293	N-Acetylgalactosaminyltransferase 12		/	Unkown
HY-RS15922	YES1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	YES1	RGD	RGD:3977
Bos taurus	YES1	VGNC	VGNC:37022
Canis familiaris	YES1	VGNC	VGNC:48484
Mus musculus	YES1	MGD	MGI:99147
Macaca mulatta	YES1	VGNC	VGNC:78817
Felis catus	YES1	VGNC	VGNC:67136
Others	YES1	NCBI

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