2. Gene
  3. H3C1 - H3 clustered histone 1 Gene

H3C1 - H3 clustered histone 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as H3/A; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3FA; H3C10; H3C11; H3C12; HIST1H3A

Gene ID: 8350 | Gene type: protein coding

About H3C1

Cytogenetic location: 6p22.2 Genomic coordinates (GRCh38): 6:26,020,451-26,020,958 (from NCBI)

This gene has 1 transcript (splice variant), 96 orthologues and 20 paralogues.

Summary

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]

H3C1 Products(1)

mRNA Protein Name
NM_003529.3 NP_003520.1 histone H3.1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IDA
IDA: Inferred from direct assay
30867594 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
10949293 GOA
Biological Process GO Annotation Evidence Reference Source
involved in epigenetic regulation of gene expression IDA
IDA: Inferred from direct assay
16267050 GOA
acts upstream of positive effect gene expression IDA
IDA: Inferred from direct assay
30867594 GOA
involved in nucleosome assembly IDA
IDA: Inferred from direct assay
14718166 GOA
involved in nucleosome assembly IMP
IMP: Inferred from mutant phenotype
25615412 GOA
Cellular Component GO Annotation Evidence Reference Source
part of nucleosome IDA
IDA: Inferred from direct assay
14718166 GOA
part of nucleosome IPI
IPI: Inferred from physical interaction
21812398 GOA
located in nucleus IDA
IDA: Inferred from direct assay
21636898 GOA
part of protein-containing complex IDA
IDA: Inferred from direct assay
14718166 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

H3C1 Protein Structure

Histone

Histone: Core histone H2A/H2B/H3/H4 (58 - 132)

  • 0
  • 100
  • 136 a.a.
Protein Preferred Names Protein Names

histone H3.1

H3 histone family, member A

H3C1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
H3C1 P68431 DNM2 Homo sapiens P50570-2
Y2H Array
32814053
Intra
H3C1 P68431 DNM2 Homo sapiens P50570-2
Y2H Pooling
32814053
Intra
H3C1 P68431 DNM2 Homo sapiens P50570-2
Validated Y2H
32814053
Intra
H3C1 P68431 PSEN1 Homo sapiens P49768-2
Y2H Pooling
32814053
Intra
H3C1 P68431 PSEN1 Homo sapiens P49768-2
Validated Y2H
32814053
Intra
H3C1 P68431 PSEN1 Homo sapiens P49768-2
Y2H Array
32814053
Intra
H3C1 P68431 SETD7 Homo sapiens Q8WTS6
NMR
12540855
Intra
H3C1 P68431 SETD7 Homo sapiens Q8WTS6
Methyltransferase Ass
12540855
Intra
H3C1 P68431 CDYL Homo sapiens Q9Y232
Pull Down
16415788
Intra
H3C1 P68431 AIRE Homo sapiens O43918
Pull Down
18292755
Intra
H3C1 P68431 AIRE Homo sapiens O43918
NMR
18292755
Intra
H3C1 P68431 AIRE Homo sapiens O43918
ITC
18292755
Intra
H3C1 P68431 PSEN2 Homo sapiens P49810
Y2H Array
32814053
Intra
H3C1 P68431 PSEN2 Homo sapiens P49810
Y2H Pooling
32814053
Intra
H3C1 P68431 PSEN2 Homo sapiens P49810
Validated Y2H
32814053
Intra
H3C1 P68431 CTSD Homo sapiens P07339
Validated Y2H
32814053
Intra
H3C1 P68431 CTSD Homo sapiens P07339
Y2H Pooling
32814053
Intra
H3C1 P68431 CTSD Homo sapiens P07339
Y2H Array
32814053
Cross
H3C1 P68431 SGF29 Saccharomyces cerevisiae P25554
SPR
21685874
Cross
H3C1 P68431 SGF29 Saccharomyces cerevisiae P25554
FPS
21685874
Cross
H3C1 P68431 SGF29 Saccharomyces cerevisiae P25554
X-Ray Diffraction
21685874
Intra
H3C1 P68431 DNAJC9 Homo sapiens Q8WXX5
Validated Y2H
32296183
Intra
H3C1 P68431 DNAJC9 Homo sapiens Q8WXX5
Pull Down
29568061
Intra
H3C1 P68431 DNAJC9 Homo sapiens Q8WXX5
BioID
29568061
Intra
H3C1 P68431 DNAJC9 Homo sapiens Q8WXX5
Y2H Array
32296183
Intra
H3C1 P68431 DNAJC9 Homo sapiens Q8WXX5
TAP
19410544
Intra
H3C1 P68431 DNAJC9 Homo sapiens Q8WXX5
BioID
25281560
Intra
H3C1 P68431 DNAJC9 Homo sapiens Q8WXX5
Y2H Prey Pooling
32296183
Intra
H3C1 P68431 PHF20 Homo sapiens Q9BVI0
Pull Down
16415788
Intra
H3C1 P68431 PHF20 Homo sapiens Q9BVI0
SPR
16415788
Intra
H3C1 P68431 MPHOSPH8 Homo sapiens Q99549
Pull Down
20871592
Intra
H3C1 P68431 ING4 Homo sapiens Q9UNL4
NMR
17157298
Intra
H3C1 P68431 H4C16 Homo sapiens P62805
Anti Tag CoIP
28514442
Intra
H3C1 P68431 H4C16 Homo sapiens P62805
TAP
19410544
Intra
H3C1 P68431 H4C16 Homo sapiens P62805
MAPPIT
25416956
Intra
H3C1 P68431 H4C16 Homo sapiens P62805
Anti Tag CoIP
19498464
Intra
H3C1 P68431 YWHAZ Homo sapiens P63104
CoIP
19766566
Intra
H3C1 P68431 YWHAZ Homo sapiens P63104
X-Ray Diffraction
16246723
Intra
H3C1 P68431 YWHAZ Homo sapiens P63104
Biochemical
18418070
Intra
H3C1 P68431 MCM2 Homo sapiens P49736
Anti Tag CoIP
26167883
Intra
H3C1 P68431 MCM2 Homo sapiens P49736
Anti Tag CoIP
28514442
Intra
H3C1 P68431 FBLIM1 Homo sapiens Q8WUP2
Y2H Prey Pooling
25416956
Intra
H3C1 P68431 FBLIM1 Homo sapiens Q8WUP2
Y2H Array
25416956
Intra
H3C1 P68431 TP53BP1 Homo sapiens Q12888
Pull Down
16415788
Intra
H3C1 P68431 RNF11 Homo sapiens Q9Y3C5
Y2H Array
32814053
Intra
H3C1 P68431 RNF11 Homo sapiens Q9Y3C5
Y2H Pooling
32814053
Intra
H3C1 P68431 RNF11 Homo sapiens Q9Y3C5
Validated Y2H
32814053
Intra
H3C1 P68431 PKM Homo sapiens P14618-1
Protein Kinase Assay
24606918
Intra
H3C1 P68431 HTT Homo sapiens P42858
Y2H Prey Pooling
23275563
Intra
H3C1 P68431 HTT Homo sapiens P42858
Lumier
23275563
Intra
H3C1 P68431 WDR5 Homo sapiens P61964
ITC
16946699
Intra
H3C1 P68431 KMT2A Homo sapiens Q03164
ITC
20541251
Intra
H3C1 P68431 KMT2A Homo sapiens Q03164
NMR
20541251
Intra
H3C1 P68431 KMT2A Homo sapiens Q03164
Pull Down
20541251
Intra
H3C1 P68431 A2M Homo sapiens P01023
Y2H Array
32814053
Intra
H3C1 P68431 A2M Homo sapiens P01023
Validated Y2H
32814053
Intra
H3C1 P68431 A2M Homo sapiens P01023
Y2H Pooling
32814053
Intra
H3C1 P68431 NASP Homo sapiens P49321-2
Anti Tag CoIP
19498464
Intra
H3C1 P68431 NASP Homo sapiens P49321-2
Validated Y2H
25416956
Intra
H3C1 P68431 NASP Homo sapiens P49321-2
Y2H Array
25416956
Intra
H3C1 P68431 TTR Homo sapiens P02766
Validated Y2H
32814053
Intra
H3C1 P68431 TTR Homo sapiens P02766
Y2H Array
32814053
Intra
H3C1 P68431 TTR Homo sapiens P02766
Y2H Pooling
32814053
Intra
H3C1 P68431 NASP Homo sapiens P49321
BioID
29568061
Intra
H3C1 P68431 NASP Homo sapiens P49321
Pull Down
29568061
Intra
H3C1 P68431 NASP Homo sapiens P49321
TAP
20080577
Intra
H3C1 P68431 NASP Homo sapiens P49321
TAP
19410544
Intra
H3C1 P68431 NASP Homo sapiens P49321
BioID
25281560
Intra
H3C1 P68431 WFS1 Homo sapiens O76024
Y2H Array
32814053
Intra
H3C1 P68431 WFS1 Homo sapiens O76024
Validated Y2H
32814053
Intra
H3C1 P68431 WFS1 Homo sapiens O76024
Y2H Pooling
32814053
Intra
H3C1 P68431 SGF29 Homo sapiens Q96ES7
X-Ray Diffraction
21685874
Intra
H3C1 P68431 SGF29 Homo sapiens Q96ES7
FPS
21685874
Intra
H3C1 P68431 SGF29 Homo sapiens Q96ES7
ITC
21685874
Intra
H3C1 P68431 CBX1 Homo sapiens P83916
BioID
29568061
Intra
H3C1 P68431 CBX1 Homo sapiens P83916
Pull Down
16415788
Intra
H3C1 P68431 CBX1 Homo sapiens P83916
SPR
16415788
Intra
H3C1 P68431 CBX5 Homo sapiens P45973
BioID
25281560
Intra
H3C1 P68431 CBX5 Homo sapiens P45973
Pull Down
20871592
Intra
H3C1 P68431 CBX5 Homo sapiens P45973
Anti Tag CoIP
19498464
Intra
H3C1 P68431 CBX5 Homo sapiens P45973
Anti Tag CoIP
28514442
Cross
H3C1 P68431 IPL1 Saccharomyces cerevisiae P38991
Enzymatic Study
10949293
Intra
H3C1 P68431 KDM4A Homo sapiens O75164
Pull Down
16415788
Intra
H3C1 P68431 KDM4A Homo sapiens O75164
IF
16603238
Intra
H3C1 P68431 KDM4A Homo sapiens O75164
SPR
16415788
Intra
H3C1 P68431 PEX1 Homo sapiens O43933
Validated Y2H
32814053
Intra
H3C1 P68431 PEX1 Homo sapiens O43933
Y2H Pooling
32814053
Intra
H3C1 P68431 PEX1 Homo sapiens O43933
Y2H Array
32814053
Cross
H3C1 P68431 rhi Drosophila melanogaster Q7JXA8
X-Ray Diffraction
25613572
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant H3C1 Proteins

Cat. No. Product Name Accession Purity
HY-P72332 Histone H3 Protein, Human P68431 (A2-A136) ≥95%
HY-P72335 Histone H3 Protein, Human (98a.a, His) P68431 (P39-A136) ≥95%
HY-P72798 Histone H3 Protein, Human (His) P68431 (A2-A136) ≥95%

Related Diseases

Diseases Alias
Glioma Susceptibility 1

Astrocytoma

GLM1

Glioma, Susceptibility To, Somatic

Glioblastoma, Somatic

Glioma

Glioblastoma Multiforme

Oligodendroglioma

Glioma Somatic

Astrocytic Tumor

GLM

Familial Glioma Of Brain

Gbm

Glioma 1

Glioma, Susceptibility, Type 1

Cerebral Astrocytoma

Glioblastoma

Well Differentiated Oligodendroglioma
Plasma Cell Neoplasm

Plasma Cell Dyscrasia

Paraproteinemias

Plasma Cell Tumour

Plasmacytic Tumor

Multiple Myeloma

Plasmacytoma

Plasma Cell Tumours

Plasma Cells Dyscrasia
Myeloma, Multiple

Multiple Myeloma

Plasma Cell Myeloma

Kahler Disease

Myelomatosis

Medullary Plasmacytoma

Multiple Myeloma, Resistance To

Myeloma

Plasma Cell Dyscrasia

Kahler'S Disease

Multiple Myeloma, Susceptibility To

Myeloma - Multiple

Kahler-Bozzolo Disease

Plasma Cell Myelomas

MM

Plasma Cell Neoplasm

Primary Systemic Amyloidosis

Primary Amyloidosis

Immunoglobulin Deposition Disease

Plasmacytic Myeloma

Multiple Myelomata

Multiple Myeloma Nos

Multiple Myeloma Without Mention Of Remission

Monostotic Plasma Cell Myeloma

Mm - [Multiple Myeloma]
Histone Mutated Tumor

Histone Mutated Tumour
Adult Infiltrating Astrocytic Neoplasm

Adult Infiltrating Astrocytoma

Adult Infiltrating Astrocytic Tumor
Anaplastic Oligodendroglioma, Idh-Mutant And 1p/19q-Codeleted
Diffuse Midline Glioma, H3 K27m-Mutant

Diffuse Intrinsic Pontine Glioma

Dipg

Infiltrative Brainstem Glioma
Brain Stem Cancer

Brain Stem Neoplasms

Malignant Neoplasm Of Brain Stem

Malignant Neoplasm Of Brainstem

Neoplasm Of Adult Brain Stem

Neoplasm Of Brain Stem

Primary Brain Stem Neoplasm

Primary Brain Stem Tumor

Brain Stem Neoplasm

Brain Stem--Cancer

Brain Stem Neoplasms, Primary
Hutchinson-Gilford Progeria Syndrome

Progeria

HGPS

Hutchinson-Gilford Syndrome

Hutchinson-Gilford Progeria

Hutchinson Gilford Syndrome

Hutchinson Gilford Progeria Syndrome

Hutchinson-Gilford Disease

Progeria Of Childhood

Hutchinson-Gilford-Progeria Syndrome
Childhood Brain Stem Glioma

Pediatric Glioma Of The Brainstem
Brain Stem Glioma

Brainstem Glioma

Brainstem Neuroglial Tumor

Glioma Of Brainstem
Diffuse Large B-Cell Lymphoma

Dlbcl

Diffuse Large B-Cell Lymphoma, Not Otherwise Specified

Large B-Cell Diffuse Lymphoma

Lymphoma, Large B-Cell, Diffuse

Dlbcl - [Diffuse Large B-Cell Lymphoma]

Diffuse Large Beta Cell Lymphoma
Posterior Fossa Ependymoma
Glioblastoma

Glioblastoma Multiforme

Gbm

Adult Glioblastoma Multiforme

Grade Iv Adult Astrocytic Tumor

Primary Glioblastoma Multiforme

Spongioblastoma Multiforme

Adult Glioblastoma

Primary Glioblastoma
Adult Astrocytic Tumour

Adult Astrocytoma

Adult Astrocytic Tumors
Pilomyxoid Astrocytoma
Low Grade Glioma

Benign Glioma
Pilocytic Astrocytoma

Juvenile Pilocytic Astrocytoma

Grade I Astrocytic Tumor

Piloid Astrocytoma
Central Nervous System Benign Neoplasm

Benign Neoplasm Of The Central Nervous System
Medulloblastoma

MDB

Cpnet

Localized Primitive Neuroectodermal Tumor

Classic Medulloblastoma

Medulloblastoma Predisposition Syndrome

Medulloblastoma, Somatic

Brain Medulloblastoma

Cns Pnet

Infratentorial Primitive Neuroectodermal Tumor

Neuroectodermal Tumors, Primitive

Medulloblastomas

Desmoplastic Medulloblastoma

Medulloblastoma, With Extensive Nodularity

Medulloblastoma Of Unspecified Site

Medullomyoblastoma Of Unspecified Site
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS05966 H3C1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus H3C1 RGD RGD:1598076
Mus musculus H3C1 MGD MGI:2668828