CDK4 - cyclin-dependent kinase 4 Gene

Rattus norvegicus

Gene ID: 94201 | Gene type: protein coding

About CDK4

Primary_assembly 7: 62,883,105-62,942,403 forward strand.mRatBN7.2:CM026980.1

This gene has 4 transcripts (splice variants), 229 orthologues, 24 paralogues and is associated with 48 phenotypes. Biased expression in Thymus (RPKM 573.2), Adrenal (RPKM 371.5) and 9 other tissues.

Summary

Enables cyclin binding activity and cyclin-dependent protein serine/threonine kinase activity. Involved in several processes, including positive regulation of cell size; response to hyperoxia; and response to testosterone. Located in nucleus and perinuclear region of cytoplasm. Biomarker of pancreatic cancer; prostatic hypertrophy; and urinary bladder Cancer. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); familial melanoma; glioblastoma; obesity; and type 2 diabetes mellitus. Orthologous to human CDK4 (cyclin dependent kinase 4). [provided by Alliance of Genome Resources, Apr 2022]

CDK4 Products(2)

mRNA	Protein	Name
NM_053593.3	NP_446045.1	cyclin-dependent kinase 4 isoform 1
NM_001402395.1	NP_001389324.1	cyclin-dependent kinase 4 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables cyclin binding	IPI IPI: Inferred from physical interaction	15809057	RGD
enables cyclin-dependent protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	12163013	RGD
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	8651753	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in animal organ regeneration	IEP IEP: Inferred from expression pattern	16534847	RGD
involved in cellular response to polyamine macromolecule	IEP IEP: Inferred from expression pattern	21737690	RGD
involved in circadian rhythm	IEP IEP: Inferred from expression pattern	11598123	RGD
involved in lens development in camera-type eye	IEP IEP: Inferred from expression pattern	10620399	RGD
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	18353414	RGD
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	17635516	RGD
involved in positive regulation of cell size	IMP IMP: Inferred from mutant phenotype	12163013	RGD
involved in positive regulation of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	21737690	RGD
involved in positive regulation of translation	IMP IMP: Inferred from mutant phenotype	12163013	RGD
involved in response to hyperoxia	IEP IEP: Inferred from expression pattern	18082050	RGD
involved in response to testosterone	IDA IDA: Inferred from direct assay	17962342	RGD
involved in response to toxic substance	IEP IEP: Inferred from expression pattern	17343987	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	18353414	RGD
located in nucleus	IDA IDA: Inferred from direct assay	18353414	RGD
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	15161838	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

cyclin-dependent kinase 4

PSK-J3

cell division protein kinase 4

Related Agents

Approval

Bioactive Molecules (14)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-50767	Palbociclib	Inhibitor	99.94%	Unkown
HY-16297A	Abemaciclib	Inhibitor	99.97%	Yes
HY-15777	Ribociclib	Inhibitor	99.94%	Unkown
HY-50767A	Palbociclib monohydrochloride	Inhibitor	99.98%	Unkown
HY-16297	Abemaciclib methanesulfonate	Inhibitor	99.95%	Yes
HY-A0065	Palbociclib isethionate	Inhibitor	99.99%	Unkown
HY-50767C	Palbociclib hydrochloride	Inhibitor	99.93%	Unkown
HY-15777A	Ribociclib hydrochloride	Inhibitor	99.95%	Unkown
HY-15777B	Ribociclib succinate	Inhibitor	99.93%	Unkown
HY-101467A	Trilaciclib hydrochloride	Inhibitor	99.69%	Unkown
HY-114338	Dalpiciclib	Inhibitor	99.40%	Unkown
HY-15777C	Ribociclib succinate hydrate	Inhibitor	99.96%	Unkown
HY-50767D	Palbociclib orotate	Inhibitor	/	Unkown
HY-50767B	Palbociclib dihydrochloride	Inhibitor	/	Unkown

Clinical Phase

Bioactive Molecules (28)

Cat. No.	Product Name	Effect	Purity	Phase
HY-10580	GSK 3 Inhibitor IX	Inhibitor	99.74%	Phase 4
HY-139450	Atirmociclib	Inhibitor	99.87%	Phase 3
HY-114338A	Dalpiciclib hydrochloride	Inhibitor	98.22%	Phase 3
HY-112272	Lerociclib	Inhibitor	98.35%	Phase 3
HY-10005	Flavopiridol	Inhibitor	99.73%	Phase 2
HY-101563	GSK3326595		99.97%	Phase 2
HY-103712A	Samuraciclib hydrochloride	Inhibitor	99.98%	Phase 2
HY-50940	AT7519	Inhibitor	99.76%	Phase 2
HY-10006	Flavopiridol Hydrochloride	Inhibitor	99.73%	Phase 2
HY-13914	Roniciclib	Inhibitor	98.09%	Phase 2
HY-10424	Milciclib	Inhibitor	99.90%	Phase 2
HY-112272A	Lerociclib dihydrochloride	Inhibitor	98.11%	Phase 2
HY-103712B	Samuraciclib hydrochloride dihydrate	Inhibitor	99.08%	Phase 2
HY-50943	AT7519 Hydrochloride	Inhibitor	99.42%	Phase 2
HY-103712C	Samuraciclib hydrochloride hydrate	Inhibitor	99.88%	Phase 2
HY-50940A	AT7519 TFA	Inhibitor	98.53%	Phase 2
HY-103712	Samuraciclib	Inhibitor	/	Phase 2
HY-16559A	Riviciclib	Inhibitor	/	Phase 2
HY-10008	SNS-032	Inhibitor	99.54%	Phase 1
HY-10012	AZD-5438	Inhibitor	99.85%	Phase 1
HY-10014	R547	Inhibitor	99.57%	Phase 1
HY-12624	Narazaciclib	Inhibitor	99.12%	Phase 1
HY-11001	PHA-793887	Inhibitor	99.25%	Phase 1
HY-15504	RGB-286638	Inhibitor	99.70%	Phase 1
HY-111361	FN-1501	Inhibitor	99.08%	Phase 1
HY-12422	Voruciclib	Inhibitor	99.77%	Phase 1
HY-15504A	RGB-286638 free base	Inhibitor	98.07%	Phase 1
HY-12422A	Voruciclib hydrochloride	Inhibitor	99.23%	Phase 1

Pre-clinical Phase

Bioactive Molecules (93)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-103248	Toyocamycin	Inhibitor	99.78%	Unkown
HY-10329	JNJ-7706621	Inhibitor	99.91%	Unkown
HY-15339	CVT-313	Inhibitor	99.90%	Unkown
HY-11009	CGP60474	Inhibitor	99.23%	Unkown
HY-116035	Nimbolide	Inhibitor	99.72%	Unkown
HY-136252	BSJ-04-132	Inhibitor	99.07%	Unkown
HY-114177	Ebvaciclib	Inhibitor	99.98%	Unkown
HY-136250	BSJ-03-204	Inhibitor	99.76%	Unkown
HY-138946	XY028-140	Inhibitor	98.42%	Unkown
HY-15275	BMS-265246	Inhibitor	98.92%	Unkown
HY-15878	LDC000067	Inhibitor	99.00%	Unkown
HY-18299A	Purvalanol A	Inhibitor	98.30%	Unkown
HY-12445	Asnuciclib	Inhibitor	99.76%	Unkown
HY-128669	Abemaciclib metabolite M2	Inhibitor	99.94%	Unkown
HY-13266A	BS-181 hydrochloride	Inhibitor	99.80%	Unkown
HY-18629	SU9516	Inhibitor	99.81%	Unkown
HY-119940	MC180295	Inhibitor	98.89%	Unkown
HY-126534A	Abemaciclib metabolite M18 hydrochloride	Inhibitor	98.01%	Unkown
HY-129336	Abemaciclib metabolite M20	Inhibitor	96.02%	Unkown
HY-16559	Riviciclib hydrochloride		98.89%	Unkown
HY-15569	NU6102	Inhibitor	99.23%	Unkown
HY-50767S	Palbociclib-d8	Inhibitor	99.84%	Unkown
HY-129180	XY028-133	Inhibitor	98.62%	Unkown
HY-147007	β-catenin-IN-3	Inhibitor	98.03%	Unkown
HY-15889	AMG 925	Inhibitor	98.20%	Unkown
HY-148062	RSS0680		98.03%	Unkown
HY-107419	NU6140	Inhibitor	99.07%	Unkown
HY-114339	CDK4/6-IN-2	Inhibitor	99.82%	Unkown
HY-112243A	Cimpuciclib tosylate	Inhibitor	99.16%	Unkown
HY-126251	CDK9-IN-7	Inhibitor	98.05%	Unkown
HY-142076	CDK4/6-IN-15	Inhibitor	96.15%	Unkown
HY-103380	NSC 625987	Inhibitor	98.58%	Unkown
HY-111207	CA224	Inhibitor	99.94%	Unkown
HY-100429	CAN508	Inhibitor	99.59%	Unkown
HY-112822	ON-013100	Inhibitor	98.66%	Unkown
HY-148061	DB1113		99.28%	Unkown
HY-148365	NecroIr1	Inhibitor	98.02%	Unkown
HY-153556	GW297361	Inhibitor	98.13%	Unkown
HY-152263	HEMTAC CDK4/6 degrader 1	Inhibitor	98.18%	Unkown
HY-148366	NecroIr2	Inhibitor	98.99%	Unkown
HY-100624	Ryuvidine	Inhibitor	99.40%	Unkown
HY-136726	CGP-82996	Inhibitor	98.12%	Unkown
HY-112346	RGB-286147	Inhibitor	98.60%	Unkown
HY-163786	PROTAC CDK4/6 degrader 1	Degrader	98.88%	Unkown
HY-13266	BS-181	Inhibitor	98.10%	Unkown
HY-129336S	Abemaciclib metabolite M20-d8	Inhibitor	99.26%	Unkown
HY-15889A	AMG 925 (HCl)	Inhibitor	/	Unkown
HY-126534	Abemaciclib metabolite M18	Inhibitor	/	Unkown
HY-112243	Cimpuciclib	Inhibitor	/	Unkown
HY-126244	CDK4/6-IN-3	Inhibitor	/	Unkown
HY-159155	CDK2/4-IN-1	Inhibitor	/	Unkown
HY-162530	CDK4/6-IN-20	Inhibitor	/	Unkown
HY-155602	CDK2-IN-18	Inhibitor	/	Unkown
HY-162529	CDK4/6-IN-19	Inhibitor	/	Unkown
HY-168660	CPD-10	Degrader	/	Unkown
HY-150609	SHP2/CDK4-IN-1	Inhibitor	/	Unkown
HY-147409	Ulecaciclib	Inhibitor	/	Unkown
HY-163856	CDK7-IN-30	Inhibitor	/	Unkown
HY-112328	Fascaplysin	Inhibitor	/	Unkown
HY-141685	3-Methylthienyl-carbonyl-JNJ-7706621	Inhibitor	/	Unkown
HY-153088	CDK4/6-IN-16	Inhibitor	/	Unkown
HY-115942	Anticancer agent 29	Inhibitor	/	Unkown
HY-162619	CDK9-IN-33	Inhibitor	/	Unkown
HY-160941	CDK2-IN-29	Inhibitor	/	Unkown
HY-143257	CDK4/6-IN-7	Inhibitor	/	Unkown
HY-146276	CDK/HDAC-IN-2	Inhibitor	/	Unkown
HY-146253	CDK1/2/4-IN-1	Inhibitor	/	Unkown
HY-115908	ZDLD13	Inhibitor	/	Unkown
HY-151069	TMX-2039	Inhibitor	/	Unkown
HY-164376	CDK4/6-IN-21	Inhibitor	/	Unkown
HY-148213	CDK2/4/6-IN-1	Inhibitor	/	Unkown
HY-112418	CDK4/6-IN-18	Inhibitor	/	Unkown
HY-151898	CDK4/6-IN-14	Inhibitor	/	Unkown
HY-155787	SHR5428	Inhibitor	/	Unkown
HY-115993	CDK4/6-IN-10	Inhibitor	/	Unkown
HY-115992	CDK4/6-IN-9	Inhibitor	/	Unkown
HY-164376A	CDK4/6-IN-21 maleate	Inhibitor	/	Unkown
HY-168664	CPD-39	Degrader	/	Unkown
HY-163787	YY173	Inhibitor	/	Unkown
HY-111932	Indirubin-5-sulfonate	Inhibitor	/	Unkown
HY-148214	CDK2/4/6-IN-2	Inhibitor	/	Unkown
HY-115904	FLT3/CDK4-IN-1	Inhibitor	/	Unkown
HY-123034	CDKI-83	Inhibitor	/	Unkown
HY-153336	CDK-IN-12	Inhibitor	/	Unkown
HY-163640	CDK4 degrader 1	Degrader	/	Unkown
HY-170651	CDK4/6/HDAC-IN-1	Inhibitor	/	Unkown
HY-151071	TMX-3013	Inhibitor	/	Unkown
HY-143258	CDK4/6-IN-8	Inhibitor	/	Unkown
HY-115909	ZDLD20	Inhibitor	99.84%	Unkown
HY-146213	CDK4/6-IN-12	Inhibitor	/	Unkown
HY-142696	CDK6/PIM1-IN-1	Inhibitor	/	Unkown
HY-112450	Olomoucine II	Inhibitor	/	Unkown
HY-123045	PNU-292137	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	CDK4	NCBI	NCBI:1019

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