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BRD4 Degrader

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Cytotoxin (1) Androgen Receptor (1) Apoptosis (9) Autophagy (1) c-Myc (1) Caspase (1) E3 Ligase Ligand-Linker Conjugates (6) Epigenetic Reader Domain (73) FKBP (3) Ligands for E3 Ligase (2) Ligands for Target Protein for PROTAC (5) Molecular Glues (3) PD-1/PD-L1 (1) PROTAC Linkers (4) PROTAC-Linker Conjugates for PAC (5) PROTACs (56) SNIPERs (1) Target Protein Ligand-Linker Conjugates (1)
By Research Areas:	Cancer (94) Metabolic Disease (1)
Click Chemistry:	PROTAC Synthesis (2) Azide (5) Alkynes (2)

Inhibitors & Agonists

Click Chemistry

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-111433

BRD4 degrader AT1	PROTACs Epigenetic Reader Domain	Cancer
BRD4 degrader AT1 is a PROTAC connected by ligands for von Hippel-Lindau and *BRD4* as a highly selective *Brd4* degrader, with a K_d of 44 nM for Brd4 ^BD2 in cells.

HY-133737

*PROTAC BRD4* Degrader-5**	PROTACs Epigenetic Reader Domain	Cancer
PROTAC BRD4 Degrader-5 is a PROTAC connected by ligands for von Hippel-Lindau and *BRD4. PROTAC BRD4* Degrader-5 can potent degrade *BRD4* in HER2 positive and negative breast cancer cell lines .

HY-138632

*PROTAC BRD4* Degrader-9**	PROTACs Epigenetic Reader Domain	Cancer
PROTAC BRD4 Degrader-9 (compound 8a) is a PROTAC connected by ligands for von Hippel-Lindau and *BRD4. PROTAC BRD4* Degrader-9 can be conjugated with STEAP1 and CLL1 antibodies to degrade the BRD4 protein in PC3 prostate cancer cells, with a DC₅₀ of 0.86 nM and 7.6 nM, respectively .

HY-129938

*PROTAC BRD4* Degrader-24**	PROTAC-Linker Conjugates for PAC	Cancer
PROTAC BRD4 Degrader-24 (compound 5), a PROTAC-linker Conjugate for PAC, comprises the chimeric BET degrader GNE-987 and disulfide-containing linker .

HY-133131

*PROTAC BRD4* Degrader-1**	PROTACs Epigenetic Reader Domain	Cancer
PROTAC BRD4 Degrader-1 is a PROTAC connected by ligands for Cereblon and *BRD4* with an IC₅₀ of 41.8 nM against BRD4 BD1. PROTAC BRD4 Degrader-1 can effectively degrade BRD4 protein and suppress c-Myc expression .

HY-163638

BRD4 degrader-1	Molecular Glues Epigenetic Reader Domain	Cancer
BRD4 degrader-1 (Compound ML 1-50) is a monovalent and covalent molecular glue *BRD4* degrader. BRD4 degrader-1 targets DCAF16 (E3 ligase) and degrades both the long and short isoforms of BRD4 in cells .

HY-163639

BRD4 degrader-2	Molecular Glues Epigenetic Reader Domain	Cancer
BRD4 degrader-2 (Compound JP-2-197) is a covalent monovalent molecular glue *BRD4*degrader that induces a ternary complex formation between BRD4 and RNF126. BRD4 degrader-2 targets RNF126 (E3 ligase) and degrades both the long and short isoforms of BRD4 in cells .

HY-136857

BRD4 degrader-3	Epigenetic Reader Domain	Cancer
BRD4 degrader-3 is a potent bromodomain BRD4 degrader extracted from patent WO2020055976A1, example 1a, has IC₅₀s of 15.5 and 12.3 nM for BRD4-BD1 and BRD4-BD2, respectively . PROTAC BRD4 Degrader-7 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-133136

*PROTAC BRD4* Degrader-2**	PROTACs Epigenetic Reader Domain	Cancer
PROTAC BRD4 Degrader-2 is a PROTAC connected by ligands for Cereblon and *BRD4* with an IC₅₀ of 14.2 nM against BRD4 BD1 .

HY-131203

*PROTAC BRD4* Degrader-6**	Epigenetic Reader Domain Apoptosis c-Myc Caspase	Cancer
PROTAC BRD4 Degrader-6 (compound 32a) is a potent small-molecule *BRD4* degrader with IC₅₀ value of 2.7 nM for BRD4 BD1. PROTAC BRD4 Degrader-6 potently degrades BRD4 protein and inhibits the expression of c-Myc. PROTAC BRD4 Degrader-6 inhibits the proliferation of pancreatic cancer cell line BxPC3 and induces apoptosis. PROTAC BRD4 Degrader-6 can be used for human pancreatic cancer research .

HY-143327

*PROTAC BRD4* Degrader-16**	PROTACs Epigenetic Reader Domain Apoptosis	Cancer
PROTAC BRD4 Degrader-16 is a potent PROTAC BRD4 Degrader, with IC₅₀ values of 34.58 nM (BRD4 (BD1)) and 40.23 nM (BRD4 (BD2)). PROTAC BRD4 Degrader-16 ignificantly attenuates G2/M progression associated Cyclin B1 expression. PROTAC BRD4 Degrader-16 significantly induces apoptosis in MV-4-11 cells .

HY-153459

*PROTAC BRD4* Degrader-19**	PROTACs Epigenetic Reader Domain	Cancer
PROTAC BRD4 Degrader-19 (compound 176) is a PROTAC that targets *BRD4* protein for degradation. PROTAC BRD4 Degrader-19 can be used in cancer research .

HY-143328

*PROTAC BRD4* Degrader-17**	PROTACs Epigenetic Reader Domain Apoptosis	Cancer
PROTAC BRD4 Degrader-17 (compound 13i) is a potent PROTAC BRD4 Degrader, with IC₅₀ values of 29.54 nM (BRD4 (BD1)) and 3.82 nM (BRD4 (BD2)). PROTAC BRD4 Degrader-17 significantly attenuates G2/M progression associated Cyclin B1 expression. PROTAC BRD4 Degrader-17 significantly induces apoptosis in MV-4-11 cells .

HY-138555

*PROTAC BRD4* Degrader-8**	PROTACs Epigenetic Reader Domain	Cancer
PROTAC BRD4 Degrader-8 is a PROTAC connected by ligands for von Hippel-Lindau and *BRD4, with IC₅₀s of 1.1 nM and 1.4 nM for BRD4* BD1 and BD2, respectively. PROTAC BRD4 Degrader-8 is capable of potently degrading the BRD4 protein in PC3 prostate cancer cells .

HY-138637

*PROTAC BRD4* Degrader-14**	PROTACs Epigenetic Reader Domain	Cancer
PROTAC BRD4 Degrader-14 is a PROTAC connected by ligands for von Hippel-Lindau and *BRD4, with IC₅₀s of 1.8 nM and 1.7 nM for BRD4* BD1 and BD2, respectively. PROTAC BRD4 Degrader-14 is capable of potently degrading the BRD4 protein in PC3 prostate cancer cells .

HY-139294

*PROTAC BRD4* Degrader-15**	PROTACs Epigenetic Reader Domain	Cancer
PROTAC BRD4 Degrader-15 is a PROTAC connected by ligands for von Hippel-Lindau and *BRD4, with IC₅₀s of 7.2 nM and 8.1 nM for BRD4* BD1 and BD2, respectively. PROTAC BRD4 Degrader-15 is capable of potently degrading the BRD4 protein in PC3 prostate cancer cells .

HY-160527

*PROTAC BRD4* Degrader-25**	Epigenetic Reader Domain	Cancer
PROTAC BRD4 Degrader-25 (Compound 1-f) is a *BRD4* degrader. PROTAC BRD4 Degrader-25 can be used for the research of cancer and other bromodomain related diseases .

HY-153820

*PROTAC BRD4* Degrader-20**	Epigenetic Reader Domain PROTACs	Cancer
PROTAC BRD4 Degrader-20 (compound 195) is an bifunctional compound and an degrader of *BRD4* .

HY-156566

*PROTAC BRD4* Degrader-21**	Epigenetic Reader Domain PROTACs	Cancer
PROTAC BRD4 Degrader-21 (Comp 74) is a PROTAC degrader of *BRD4. PROTAC BRD4* Degrader-21 displays significant tumor growth inhibition in tumor -bearing xenograft models in mice and can be used for anticancer research .

HY-138633

*PROTAC BRD4* Degrader-10**	PROTACs Epigenetic Reader Domain	Cancer
PROTAC BRD4 Degrader-10 (compound 8b) is a PROTAC connected by ligands for von Hippel-Lindau and *BRD4. PROTAC BRD4* Degrader-10 can be conjugated with STEAP1 and CLL1 antibodies to degrade the BRD4 protein in PC3 prostate cancer cells, with a DC₅₀ of 1.3 nM and 18 nM, respectively .

HY-138634

*PROTAC BRD4* Degrader-11**	PROTACs PROTAC-Linker Conjugates for PAC Epigenetic Reader Domain	Cancer
PROTAC BRD4 Degrader-11 (compound 9a) is a PROTAC connected by ligands for von Hippel-Lindau and *BRD4. PROTAC BRD4* Degrader-11 can be conjugated with STEAP1 and CLL1 antibodies to degrade the BRD4 protein in PC3 prostate cancer cells, with a DC₅₀ of 0.23 nM and 0.38 nM, respectively .

HY-138635

*PROTAC BRD4* Degrader-12**	PROTACs PROTAC-Linker Conjugates for PAC Epigenetic Reader Domain	Cancer
PROTAC BRD4 Degrader-12 (compound 9c) is a PROTAC connected by ligands for von Hippel-Lindau and *BRD4. PROTAC BRD4* Degrader-12 can be conjugated with STEAP1 and CLL1 antibodies to degrade the BRD4 protein in PC3 prostate cancer cells, with a DC₅₀ of 0.39 nM and 0.24 nM, respectively .

HY-133736

*PROTAC BRD4* Degrader-5-CO-PEG3-N3**	PROTAC-Linker Conjugates for PAC ADC Cytotoxin	Cancer
PROTAC BRD4 Degrader-5-CO-PEG3-N3 (Compound 2) is a PROTAC-linker Conjugate for PAC, comprises the BRD4 degrader GNE-987 and PEG-based linker . PROTAC BRD4 Degrader-5-CO-PEG3-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-138636

*PROTAC BRD4* Degrader-13**	PROTAC-Linker Conjugates for PAC Epigenetic Reader Domain	Cancer
PROTAC BRD4 Degrader-13 (compound 9d) is a von Hippel-Lindau system-based PROTAC *BRD4* degrader with a linker that can be coupled to ADC antibodies to form PACs (PROTAC-antibody Conjugates). PROTAC BRD4 Degrader-13 can be coupled to STEAP1 and CLL1 antibodies to degrade BRD4 protein in PC3 prostate cancer cells with DC₅₀ values of 0.025 nM and 6.0 nM, respectively .

HY-135558

*PROTAC BRD4* Degrader-3**	PROTACs Epigenetic Reader Domain	Cancer
PROTAC BRD4 Degrader-3 (compound 1004.1) is an efficacious PROTAC connected by ligands for von Hippel-Lindau and *BRD4* .

HY-155393

*PROTAC BRD4* Degrader-22**	PROTACs Epigenetic Reader Domain	Cancer
PROTAC BRD4 Degrader-22 (Compd 44h) is a PROTAC-based *BRD4* degrader, with a pDC₅₀ (MOLT4, 24 h) of 9.2 .

HY-161650

*PROTAC BRD4* Degrader-26**	PROTACs Epigenetic Reader Domain	Cancer
PROTAC BRD4 Degrader-26 (PROTAC-2) is a photo-regulated PROTAC, which degrades 80% *BRD4* at 1 μM by using photocleavable linker. PROTAC BRD4 Degrader-26 will be deactivated by UV light. (Pink: ligand for target protein BRD4 ligand 6 (HY-161651); Black: linker (HY-161653); Blue: E3 ligase ligand Thalidomide 4-fluoride (HY-41547))

HY-161093

*PROTAC BRD4* Degrader-23**	PROTACs	Cancer
PROTAC BRD4 Degrader-23 (compound 17) is an effective visible-light-controlled degrader. PROTAC BRD4 Degrader-23 can inhibit tumor cell proliferation under 405 nm light irradiation .

HY-160694

*cBu-Cit-PROTAC BRD4* Degrader-5**	PROTACs	Cancer
cBu-Cit-PROTAC BRD4 Degrader-5 is a cBu-Cit conjugated PROTAC degrader. cBu-Cit-PROTAC BRD4 Degrader-5 can potently degrade BRD4 in HER2 positive and negative breast cancer cell lines .

HY-162875

*PROTAC BRD4* Degrader-27**	PROTACs Epigenetic Reader Domain	Cancer
PROTAC BRD4 Degrader-27 (compound 6b) is a PROTAC that selectively targets BRD4 (rather than BRD2/BRD3) and can also inhibit the expression of KLF5 transcription factor and exert anti-cancer activity. PROTAC *BRD4* Degrader-27 is composed of E3 ubiquitinase ligand Thalidomide-4-OH (HY-103596) (red part), PROTAC Linker γ-Aminobutyric acid (HY-N0067) (black part) and PROTAC target protein ligand PROTAC *BRD4* ligand-3 (HY-162876) (blue part), of which the active control of the target protein ligand is Mivebresib (HY-100015), and the conjugate of E3 ubiquitin ligase ligand + Linker is Pomalidomide 4'-alkylC3-acid (HY-131875) ^{[1] ^.}

HY-169151

*PROTAC BRD4-DCAF1 degrader-1*	PROTACs Epigenetic Reader Domain Ligands for E3 Ligase	Cancer
PROTAC BRD4-DCAF1 degrader-1 (I-907) is a *BRD4-DCAF1* PROTAC degrader, DC₅₀ is 10~100 nM. (Pink: BRD4-DCAF1 ligand (HY-169152); Black: linker (HY-126976); Blue: E3 ligase ligand (HY-15846)) .

HY-130612

*PROTAC BRD2/BRD4* degrader-1**	Epigenetic Reader Domain PROTACs	Cancer
PROTAC BRD2/BRD4 degrader-1 (compound 15) is a potent and selective BET protein *BRD4* and BRD2 degrader, connected by ligands for Cereblon and BET. PROTAC BRD2/BRD4 degrader-1 rapidly induces reversible, long-lasting, and unexpectedly selective removal of BRD4 and BRD2 over BRD3. It effectively inhibits solid tumors with low cytotoxic effect. PROTAC BRD2/BRD4 degrader-1 is composed of the BET inhibitor, a linker, and the ligand thalidomide for cereblon (CRBN)/cullin 4A .

HY-149948

*PROTAC BRD3/BRD4-L degrader-2*	Epigenetic Reader Domain PROTACs	Cancer
PROTAC BRD3/BRD4-L degrader-2 is a PROTAC molecule and can selectively degrade cellular BRD3 and *BRD4-L* with K_i values of 16.91 and 2.8 nM, respectively. PROTAC BRD3/BRD4-L degrader-2 also has robust antitumor activity in mouse xenograft models. PROTAC BRD3/BRD4-L degrader-2 can be used for the research of cancer .

HY-156828

MMH2	Others	Others
MMH2 is a novel BRD4 molecular glue degrader that functions by recruiting the CUL4 and DCAF16 ligases to the second bromodomain of BRD4 (BRD4_BD2) .

HY-156827

MMH1	Others	Others
MMH1 is a novel BRD4 molecular glue degrader that functions by recruiting the CUL4 and DCAF16 ligases to the second bromodomain of BRD4 (BRD4_BD2) .

HY-161368

BRD-SF2	PROTACs Epigenetic Reader Domain	Cancer
BRD-SF2 is a *BRD4*-targeted PROTAC degrader (DC₅₀: 17.2 μM) (Blue: VHL ligand, black: linker, pink: BRD4 ligand) .

HY-163019

EN884	Target Protein Ligand-Linker Conjugates Epigenetic Reader Domain	Metabolic Disease
EN884 is a BRD4 degrader via a SKP1- and proteasome-dependent manner. EN884 can be used in synthetic proteolysis targeting chimeras (PROTACs) .

HY-161651

BRD4 ligand 6	Epigenetic Reader Domain	Cancer
BRD4 ligand 6 is a *BRD4* ligand and can be used for synthesis of BRD4 PROTACs, such as PROTAC BRD4 Degrader-26 (HY-161650) .

HY-161651A

BRD4 ligand 6 TFA	Epigenetic Reader Domain	Cancer
BRD4 ligand 6 TFA is the TFA salt form of BRD4 ligand 6 (HY-161651). BRD4 ligand 6 TFA is a *BRD4* ligand and can be used for synthesis of BRD4 PROTACs, such as PROTAC BRD4 Degrader-26 (HY-161650) .

HY-160528

IBG3	Epigenetic Reader Domain Molecular Glues	Cancer
IBG3 is a dual-JQ1-containing BET degrader that targets protein degradation via intramolecular bivalent glues. IBG3 is a BRD2 and *BRD4* bifunctional degrader with DC₅₀ values of 8.6 pM and 6.7 pM, respectively .

HY-153385

TMX1	Epigenetic Reader Domain Apoptosis	Cancer
TMX1 is a *BRD4* covalent molecular glue degrader. TMX1 selectively recruits DCAF16 to BRD4BD2, resulting in the degradation of BRD4 .

HY-162876

PROTAC BRD4 ligand-3	Ligands for Target Protein for PROTAC	Cancer
PROTAC BRD4 ligand-3 is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). PROTAC BRD4 ligand-3 can be used for synthesis PROTAC BRD4 Degrader-27 (HY-162875) .

HY-114305

A1874	PROTACs Epigenetic Reader Domain	Cancer
A1874 is a nutlin-based (MDM2 ligand) and *BRD4*-degrading PROTAC with a DC₅₀ of 32 nM (induce BRD4 degradation in cells). Effective in inhibiting many cancer cell lines proliferation .

HY-132991

ML 2-14	PROTAC Linkers	Cancer
ML 2-14 is a PROTAC for degrading *BRD4, with C4 alkyl linker. ML 2-14 exerts degradation* of BRD4 in 231MFP breast cancer cells .

HY-107442

PROTAC BRD4-binding moiety 1	Epigenetic Reader Domain Ligands for Target Protein for PROTAC	Cancer
PROTAC BRD4-binding moiety 1 is a ligand for BRD4. PROTAC BRD4-binding moiety 1 binds to cereblon ligand via a linker to form PROTAC to degrade BRD4 (HY-133136) . PROTAC BRD4-binding moiety 1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-114406

TD-106	Ligands for E3 Ligase	Cancer
TD-106 is a cereblon (CRBN) modulator, which can be used for targeted protein degradation. BRD4 PROTACs with TD-106 induce BRD4 degradation .

HY-111977

ZEN-3219	Epigenetic Reader Domain	Cancer
ZEN-3219 is a BET inhibitor with IC₅₀s of 0.48, 0.16 and 0.47 μM for *BRD4(BD1), BRD4(BD2)* and *BRD4(BD1BD2), respectively. ZEN-3219 can be used to form PROTACs to induce degradation* of BRD4 .

HY-111979

ZEN-3411	Epigenetic Reader Domain	Cancer
ZEN-3411 is a BET inhibitor with IC₅₀s of 0.05, 0.05 and 0.06 μM for *BRD4(BD1), BRD4(BD2)* and *BRD4(BD1BD2), respectively. ZEN-3411 can be used to form PROTACs to induce degradation* of BRD4 .

HY-112718

PROTAC BET Degrader-10	PROTACs Epigenetic Reader Domain	Cancer
PROTAC BET Degrader-10 is a potent BET protein *BRD4* degrader extracted from patent WO2017007612A1, example 37, connected by ligands for Cereblon and *BRD4, with a DC₅₀* of 49 nM .

HY-111978

ZEN-3862	Epigenetic Reader Domain	Cancer
ZEN-3862 is a BET inhibitor with IC₅₀s of 0.16 and 0.13 μM for BRD4(BD1) and BRD4(BD2) , respectively. ZEN-3862 can be used to form PROTACs to induce degradation of BRD4 .

Cat. No.	Product Name		Classification

HY-133736

*PROTAC BRD4* Degrader-5-CO-PEG3-N3**		Azide
PROTAC BRD4 Degrader-5-CO-PEG3-N3 (Compound 2) is a PROTAC-linker Conjugate for PAC, comprises the BRD4 degrader GNE-987 and PEG-based linker . PROTAC BRD4 Degrader-5-CO-PEG3-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-107442

PROTAC BRD4-binding moiety 1		Alkynes
PROTAC BRD4-binding moiety 1 is a ligand for BRD4. PROTAC BRD4-binding moiety 1 binds to cereblon ligand via a linker to form PROTAC to degrade BRD4 (HY-133136) . PROTAC BRD4-binding moiety 1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-133139

Lenalidomide-PEG1-azide		Azide
Lenalidomide-PEG1-azide is a E3 ligase lgand-linker conjugate. Lenalidomide-PEG1-azide incorporates the Lenalidomide based cereblon ligand and a linker.?Lenalidomide-PEG1-azide?can be used to design a PROTAC BRD4 Degrader-2 (HY-133136) . Lenalidomide-PEG1-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-133138

Pomalidomide-PEG1-azide		Azide
Pomalidomide-PEG1-azide is a E3 ligase lgand-linker conjugate. Pomalidomide-PEG1-azide incorporates the Pomalidomide based cereblon ligand and a linker.?Pomalidomide-PEG1-azide?can be used to design a?PROTAC BRD4 Degrader-1 (HY-133131) . Pomalidomide-PEG1-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-108369

Azido-PEG1-CH2CO2H		PROTAC Synthesis Azide
Azido-PEG1-CH2CO2H is a PROTAC linker, which refers to the alkyl/ether composition. Azido-PEG1-CH2CO2H can be used in the synthesis of PROTAC BRD4 Degrader-1 . Azido-PEG1-CH2CO2H is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-159777

CPI-203-PEG5-Alkyne		Alkynes
CPI-203-PEG5-Alkyne is a conjugate of E3 ligase and linker. CPI-203-PEG5-Alkyne can be used for synthesis of PROTAC BRD4-DCAF1 degrader-1 (HY-169151) .

HY-130984

Azido-PEG1-CH2COO-Cl		PROTAC Synthesis Azide
Azido-PEG1-CH2COO-Cl (compound 43a) is an alkyl/ether-based PROTAC linker. Azido-PEG1-CH2COO-Cl can be used in the synthesis of PROTAC BRD4 Degrader-1 (HY-133131) . Azido-PEG1-CH2COO-Cl is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

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