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Results for "

Flt-3

" in MedChemExpress (MCE) Product Catalog:

By Targets:	FLT3 (198) AAK1 (1) ADC Antibody (1) Akt (3) AMPK (1) Anaplastic lymphoma kinase (ALK) (1) Apoptosis (75) Aurora Kinase (11) Autophagy (16) Bcr-Abl (12) Btk (2) c-Fms (10) c-Kit (33) c-Met/HGFR (13) CaMK (1) Casein Kinase (1) Caspase (3) CDK (16) Checkpoint Kinase (Chk) (3) Cytochrome P450 (1) Discoidin Domain Receptor (4) Drug Metabolite (1) EGFR (2) ERK (1) FAK (1) Ferroptosis (6) FGFR (14) Haspin Kinase (2) HDAC (7) IAP (1) IFNAR (1) IRAK (2) Isotope-Labeled Compounds (3) JAK (21) Ligands for Target Protein for PROTAC (4) LIM Kinase (LIMK) (1) MAP4K (2) MEK (2) MELK (2) Microtubule/Tubulin (1) MNK (1) NO Synthase (2) PDGFR (31) Pim (2) PKA (1) PKC (3) Polo-like Kinase (PLK) (1) PROTACs (10) RAD51 (2) Raf (6) RET (11) ROS Kinase (2) Salt-inducible Kinase (SIK) (1) Small Interfering RNA (siRNA) (4) Src (6) STAT (4) Syk (11) TAM Receptor (12) Target Protein Ligand-Linker Conjugates (1) Tie (1) Topoisomerase (1) Trk Receptor (8) ULK (1) VEGFR (37)
By Research Areas:	Cancer (228) Cardiovascular Disease (2) Inflammation/Immunology (23) Metabolic Disease (1) Neurological Disease (2)
Oligonucleotides:	Pre-designed siRNA Sets (4) siRNAs (4)

239

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Oligonucleotides

Targets Recommended: FLT3

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-112145

FLT3-IN-3 2 Publications Verification	FLT3	Cancer
FLT3-IN-3 is a potent *FLT3* inhibitor with IC₅₀s of 13 and 8 nM for FLT3 WT and FLT3 D835Y, respectively.

HY-128572

FLT3-IN-6	FLT3	Cancer
FLT3-IN-6 is a potent and selective inhibitor of *FLT3-ITD* (FLT3 mutation) with an IC₅₀ of 1.336 nM .

HY-112475

Flt-3 Inhibitor III	Tie FLT3	Cancer
Flt-3 Inhibitor III is a potent and selective FLT3 kinase inhibitor with an ₅₀ of 50 nM. Flt-3 Inhibitor III shows less active against other kinases. Flt-3 Inhibitor III has anticancer effects .

HY-RS04990

FLT3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
FLT3 Human Pre-designed siRNA Set A contains three designed siRNAs for FLT3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

FLT3 Human Pre-designed siRNA Set A FLT3 Human Pre-designed siRNA Set A

HY-RS04991

Flt3 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Flt3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Flt3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Flt3 Mouse Pre-designed siRNA Set A Flt3 Mouse Pre-designed siRNA Set A

HY-RS04992

Flt3 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Flt3 Rat Pre-designed siRNA Set A contains three designed siRNAs for Flt3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Flt3 Rat Pre-designed siRNA Set A Flt3 Rat Pre-designed siRNA Set A

HY-144777

FLT3-IN-14	FLT3 Apoptosis	Cancer
FLT3-IN-14 is a potent *FLT3* inhibitor with IC₅₀s of 5.6 nM and 1.4 nM for FLT3-WT and FLT3-ITD. FLT3-IN-14 reduces the phosphorylation of FLT3 (Y591), induces cell cycle arrest at G1 phase and apoptosis. FLT3-IN-14 significantly reduces the tumor growth in an MV4-11 xenograft mouse model .

HY-162032

FLT3-IN-25	FLT3	Cancer
FLT3-IN-25 (compound 17) is a potent inhibitor of *FLT3, with IC₅₀s of 1.2 nM, 1.4 nM and 1.1 nM for FLT3-WT, FLT3-D835Y and FLT3-ITD, respectively. FLT3*-IN-25 plays an important role in acute myeloid leukemia (AML) .

HY-148522

FLT3-IN-18	FLT3	Cancer
FLT3-IN-18 is a potent and selective *FLT3* inhibitor with an IC₅₀ value of 0.003 μM. FLT3-IN-18 induces apoptosis and cell cycle arrest at G1 phase. FLT3-IN-18 inhibits FLT3 and STAT5 phosphorylation. FLT3-IN-18 has the potential for the research of acute myeloid leukemia (AML) .

HY-156410

FLT3-IN-23	FLT3	Cancer
FLT3-IN-23 (compound 15) is an inhibitor of JFMS-like tyrosine kinase 3 (FLT3) with an IC₅₀ of 7.42 nM. FLT3-IN-23 has antiproliferative activities against BaF3 cells carrying various FLT3-TKD and FLT3-ITD-TKD mutations .

HY-146886

FLT3-IN-15	FLT3	Cancer
FLT3-IN-15 is a highly potent and orally active *FLT3* inhibitor with IC₅₀s of 0.87 nM and 0.32 nM for FLT3 and FLT3/D835Y, respectively. FLT3-IN-15 can be used for researching acute myeloid leukemia .

HY-155770

FLT3-IN-20	FLT3	Cancer
FLT3-IN-20 (compound 34f) is a potent FLT3 inhibitor with IC₅₀ values of 1 and 4 nM for FLT3-D835Y and FLT3-ITD, respectively. FLT3-IN-20 has anti-proliferation efficacy in FLT3-ITD-positive AML cell lines MV4-11 and MOLM-13 (7 and 9 nM, respectively) and the MOLM-13 variant (4 nM) with the FLT3-ITD-D835Y mutation. FLT3-IN-20 can be used in research of cancer .

HY-134481

FLT3-IN-10	FLT3	Cancer
FLT3-IN-10 (compound 7c) is a potent inhibitor of FMS-like tyrosine kinase 3 (FLT3). FLT3-IN-10 has the potential for the research of FLT3-mutated acute myeloid leukemia (AML) .

HY-144710

FLT3/ITD-IN-2	FLT3	Cancer
FLT3/ITD-IN-2 (Compound 17) is a potent FLT3 internal tandem duplications (FLT3-ITD) inhibitor with IC₅₀ values of 0.3, 0.4 and 1.0 nM against FLT3 ^D835Y, *FLT3* and FLT3-ITD, respectively. FLT3/ITD-IN-2 potently inhibits the phosphorylation of FLT3 and displays excellent antiproliferative activities against acute myeloid leukemia cell lines .

HY-144711

FLT3/ITD-IN-3	FLT3	Cancer
FLT3/ITD-IN-3 (Compound 19) is a potent FLT3 internal tandem duplications (FLT3-ITD) inhibitor with IC₅₀ values of 0.3, 0.4 and 0.9 nM against FLT3 ^D835Y, *FLT3* and FLT3-ITD, respectively. FLT3/ITD-IN-3 potently inhibits the phosphorylation of FLT3 and displays excellent antiproliferative activities against acute myeloid leukemia cell lines .

HY-143894

FLT3-IN-11	FLT3	Cancer
FLT3-IN-11 (compound 30) is a potent, selective and orally active FLT3 kinase inhibitor with IC₅₀s of 7.22 nM and 4.95 nM for wild-type FLT3 and *FLT3-D835Y, respectively. FLT3-IN-11 high selectivity for FLT3* over c-KIT (>1000-fold). FLT3-IN-11has excellent anti-acute myeloid leukemia (AML) activity (MV4-11 cells, IC₅₀ of 3.2 nM) .

HY-148036

FLT3-IN-16	FLT3	Cancer
FLT3-IN-16 is a potent *FLT3* inhibitor with an IC₅₀ of 1.1 μM. FLT3-IN-16 can be used for researching acute myeloid leukemia .

HY-143895

FLT3-IN-12	FLT3	Cancer
FLT3-IN-12 is a potent, selective and orally active FLT3 kinase inhibitor with IC₅₀s of 1.48 nM and 2.87 nM for *FLT3-WT* and *FLT3-D835Y, respectively. FLT3-IN-12 possesses high selectivity over c-KIT (>1000-fold). FLT3-IN-12 has an excellent anti-AML (acute myeloid leukemia) activity (MV4-11, IC₅₀* of 0.75 nM) .

HY-153473

FLT3-IN-19	FLT3	Cancer
FLT3-IN-19 (Comp 50) is a potent and selective *FLT3* inhibitor with IC₅₀ of 0.213 nM. FLT3-IN-19 can be used in AML disease research .

HY-163068

FLT3-IN-24	FLT3	Cancer
FLT3-IN-24 (compound 24) is a potent and selective inhibitor of FLT3 kinase with an IC₅₀ of 7.94 nM. FLT3-IN-24 has cell antiproliferative effects .

HY-144709

FLT3/ITD-IN-1	FLT3	Cancer
FLT3/ITD-IN-1 (Compound 1) is a potent FLT3 internal tandem duplications (FLT3-ITD) inhibitor with IC₅₀ values of 38.2 nM and 144.1 nM against *FLT3* and FLT3-ITD, respectively. FLT3/ITD-IN-1 displays excellent antiproliferative activities against acute myeloid leukemia cell lines .

HY-148070

FLT3-IN-17	FLT3 FAK Cytochrome P450	Cancer
FLT3-IN-17 inhibits CYPs and *FLT3* mutants activity (IC₅₀s: <0.5 nM for D835Y). FLT3-IN-17 is also a FAK inhibitor, with an IC₅₀ value of 12 nM. FLT3 ligand-2 can be used in the research of cancers .

HY-155302

FLT3-IN-22	FLT3	Cancer
FLT3-IN-22 (compound 22f) is a potent *FLT3* inhibitor with IC₅₀ values of 0.941 nM and 0.199 nM for FLT3 and FLT3/D835Y, respectively. FLT3-IN-22 exhibits strong antiproliferative activity against MV4-11 cells and the mutant FLT kinase expressed Ba/F3 cell lines, including FLT-D835Y and FLT3-F691L .

HY-160848

FLT3/ITD-IN-5	FLT3	Cancer
FLT3/ITD-IN-5 (Example 6) is an orally active *FLT3* and *FLT3-ITD* inhibitor, with IC₅₀ values of 0.088 and 0.348 nM, respectively. FLT3/ITD-IN-5 can be used for the research of cancer .

HY-146749

FLT3/TrKA-IN-1	FLT3 Trk Receptor Apoptosis	Cancer
FLT3/TrKA-IN-1 is a potent *FLT3/TrKA* dual kinase inhibitor with the IC₅₀s of 43.8 nM, 97.2 nM, 92.5 nM and 23.6 nM for FLT3, FLT3-ITD, FLT3-TKD and TrKA, respectively. FLT3/TrKA-IN-1 induces cell cycle arrest at the G0/G1 phase as well as apoptosis and shows antiproliferative activity in vitro. FLT3/TrKA-IN-1 has the potential for the research of Acute myeloid leukemia (AML) .

HY-148036S

FLT3-IN-16-d1	Isotope-Labeled Compounds FLT3	Cancer
FLT3-IN-16-d1 is the deuterium labeled FLT3-IN-16 (HY-148036). FLT3-IN-16 is a potent *FLT3* inhibitor with an IC₅₀ of 1.1 μM. FLT3-IN-16 can be used for researching acute myeloid leukemia .

HY-162906

FLT3/HDAC-IN-2	HDAC FLT3	Cancer
FLT3/HDAC-IN-2 is (compound 25h) a *FLT3/HDAC* dual inhibitor. FLT3/HDAC-IN-2 has antiproliferative activity against MOLM-13 cells. FLT3/HDAC-IN-2 can be used in acute myeloid leukemia research .

HY-155226

FLT3-IN-21	FLT3 Apoptosis	Cancer
FLT3-IN-21 (compound LC-3) is a potent FLT3 inhibitor (IC₅₀: 8.4 nM) and induces apoptosis. FLT3-IN-21 can arrest the cell cycle in the G1 phase and inhibit the proliferation of FLT3-ITD-positive AML cells MV-4-11 (IC₅₀: 5.3 nM). In mice, FLT3-IN-21 (10 mg/kg/d) inhibited tumor growth in the MV-4-11 xenograft model (TGI=92.16%) .

HY-143278

FLT3-IN-13	Topoisomerase FLT3 Apoptosis	Cancer
FLT3-IN-13 (compound 20) is a potent and effective antileukemic topoisomerase II and *FLT3* dual inhibitor with IC₅₀ values of 2.26 μM and 2.26 μM, respectively. FLT3-IN-13 arrests cell cycle at G2/M phase and induce apoptosis. FLT3-IN-13 has anticytotoxic activity, particularly against leukemia .

HY-169076

FLT3/HDAC-IN-1	FLT3 HDAC Apoptosis	Cancer
FLT3/HDAC-IN-1 is a dual inhibitor of *FLT3/HDAC, with IC₅₀* values of 30.4, 52.4, and 14.7 nM for FLT3, HDAC1, and HDAC3, respectively. FLT3/HDAC-IN-1 can induce apoptosis in MV-4-11 cells and has anti-proliferative effects on FLT3 mutant-transformed BaF3 cells. FLT3/HDAC-IN-1 is being researched for its potential in treating hard-to-treat solid tumors and hematological malignancies .

HY-18744

FLT3-IN-2	FLT3	Cancer
FLT3-IN-2 is a FLT3 inhibitor with IC50 of ＜ 1 μM, detailed information refer to WO 2012158957 A2 and WO 2007013896.

HY-146680

FLT3/ITD-IN-4	FLT3 RET CDK MAP4K	Cancer
FLT3/ITD-IN-4 (Compound 16) is a selective FMS-like tyrosine kinase 3 internal tandem duplications (FLT3-ITD) inhibitor with an IC₅₀ of 2.3 nM. FLT3/ITD-IN-4 can be used for acute myeloid leukemia research .

HY-115904

FLT3/CDK4-IN-1	CDK FLT3	Cancer
FLT3/CDK4-IN-1 is a potent, high selective and orally active *FLT3/CDK4* dual inhibitor (IC₅₀=11 and 7 nM for FLT3 and CDK4, respectively). FLT3/CDK4-IN-1 has antiproliferative activities against certain cancer cells. FLT3/CDK4-IN-1 has good antitumor effect in vivo .

HY-161709

FLT3/CDKs ligand-1	Ligands for Target Protein for PROTAC FLT3 CDK	Cancer
FLT3/CDKs ligand-1 (Compound 14) is a ligand for target protein, which promotes the degradation of cyclin-dependent kinase (CDK) and the FMS-like tyrosine kinase 3 (FLT3), inhibits FLT3/CDK related proliferations and survivals of leukemia cells. LT3/CDKs ligand-1 can be used for synthesis of PROTAC FLT3/CDKs degrader-1 (HY-161708) .

HY-162367

FLT3/CHK1-IN-2	FLT3 Checkpoint Kinase (Chk)	Cancer
FLT3/CHK1-IN-2 (Compound 30) is a dual inhibitor of *FLT3* and CHK1, with IC₅₀s of 25.63, 16.39, 22.80 nM for CHK1, FLT3-WT, and FLT-D835Y respectively. FLT3/CHK1-IN-2 has favorable oral PK properties and kinase selectivity. FLT3/CHK1-IN-2 can be used for research of acute myeloid leukemia (AML) .

HY-128571

FLT3-IN-4	FLT3	Cancer
FLT3-IN-4 is a potent and orally effective Fms-like tyrosine receptor kinase 3 (FLT3; IC₅₀=7 nM) inhibitor for treating acute myelogenous leukemia .

HY-155195

FLT3/CHK1-IN-1	Others	Cancer
FLT3/CHK-IN-1 (Compound 18) is a dual inhibitor of FLT3/CHK1. FLT3/CHK-IN-1 is more than 1700 times more selective to c-KI T and greatly reduces hERG affinity with an IC₅₀ value of 58.4 μM. FLT3/CHK-IN-1 inhibits tumor growth in mouse xenotransplantation models inoculated with MV-4-11 cells .

HY-161323

FLT3-ITD/D835Y-IN-1	FLT3 Bcr-Abl Apoptosis	Cancer
FLT3-ITD/D835Y-IN-1 (Compound 1) is a *FLT3-ITD* and BCR-ABL inhibitor. FLT3-ITD/D835Y-IN-1 mediates proapoptosis by inhibiting the FLT3 and BCR-ABL pathways, as well as other possible targets. FLT3-ITD/D835Y-IN-1 can be used in the study of acute myeloid leukemia (AML) .

HY-143434

FLT3/D835Y-IN-1	FLT3	Cancer
FLT3/D835Y-IN-1 (compound 13a) is a orally active, potent and selective *FLT3* and *FLT3/D835Y* inhibitor, with IC₅₀ values of 0.26 nM and 0.18 nM, respectively. FLT3/D835Y-IN-1 also blocks tumor growth, has anticancer efficacy, and can be used to research for AML (acute myeloid leukemia) .

HY-12960

SKLB4771 Flt3-IN-1	FLT3 c-Kit Apoptosis	Cancer
SKLB4771 is a potent and selective Flt3 inhibitor with an IC₅₀ value of 10 nM. SKLB4771 downregulates the phosphorylation of FLT3/STAT5/ERK, blocks cell proliferation, and induces apoptosis in tumor tissue .

HY-158265

FLT3D835Y/F691L-IN-1	FLT3	Cancer
FLT3D835Y/F691L-IN-1 (compd 8v) is an orally active inhibitor of FLT3 3-tyrosine kinase domain D835Y/F691L secondary mutations with IC₅₀s of 1.5 and 9.7 nM. FLT3D835Y/F691L-IN-1 can be used for acute myeloid leukemia research .

HY-RS04993

FLT3LG Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
FLT3LG Human Pre-designed siRNA Set A contains three designed siRNAs for FLT3LG gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

FLT3LG Human Pre-designed siRNA Set A FLT3LG Human Pre-designed siRNA Set A

HY-158325

*PROTAC FLT-3* degrader 4**	PROTACs FLT3 Apoptosis	Cancer
PROTAC FLT-3 degrader 4 is an orally active CRBN-based *FLT3-PROTAC* degrader that potently induces FLT3-ITD degradation through the ubiquitin-proteasome system. PROTAC FLT-3 degrader 4 shows highly selective to FLT3-ITD mutant acute myeloid leukemia (AML) cells. (Blue: CRBN ligand, Black: linker; Pink: FLT3 inhibitor) .

HY-114323

*PROTAC FLT-3* degrader 1**	PROTACs FLT3 Apoptosis	Cancer
PROTAC FLT-3 degrader 1 is a von Hippel-Lindau-based PROTAC *FLT-3* internal tandem duplication (ITD) degrader with an IC₅₀ 0.6 nM. Anti-proliferative activity; apoptosis induction .

HY-161280

*PROTAC FLT-3* degrader 3**	PROTACs FLT3	Cancer
PROTAC FLT-3 degrader 3 (compound 35) is a PROTACs degrader of *FLT. PROTAC FLT-3* degrader 3 has antiproliferative activity, with IC₅₀ of 7.55 nM in MV4-11 cells .

HY-110293

*CHMFL-FLT3-122*	FLT3 Apoptosis	Cancer
CHMFL-FLT3-122 is a potent, selective and orally active FLT3 kinase with an IC₅₀ of 40 nM. CHMFL-FLT3-122 shows selectivity for FLT3 over BTK (IC₅₀ of 421 nM) and c-KIT (IC₅₀ of 559 nM) kinases. CHMFL-FLT3-122 induces apoptosis by arresting the cell cycle into the G0/G1 phase .

HY-148521

*PROTAC FLT3/CDK9 degrader-1*	CDK FLT3 PROTACs Apoptosis	Cancer
PROTAC FLT3/CDK9 degrader-1 is a potent *FLT3* and CDK9 dual PROTAC degrader. PROTAC FLT3/CDK9 degrader-1 induces apoptosis and effective degradation of target proteins FLT3 and CDK9. PROTAC FLT3/CDK9 degrader-1 has the potential for the research of FLT3-ITD mutated AML .

HY-161967

*JAK2/FLT3-IN-3*	FLT3 JAK Apoptosis	Cancer
JAK2/FLT3-IN-3 (11r) is a dual *FLT3* and JAK2 inhibitor, with IC₅₀ values of 2.01 nM, 0.51 nM and 104.40 nM for JAK2, FLT3 and JAK3, respectively. JAK2/FLT3-IN-3 (11r) induces apoptosis and possesses antitumor activity .

HY-130247

Flonoltinib 1 Publications Verification JAK2/Flt3-IN-1	JAK FLT3 Apoptosis	Cancer
JAK2/FLT3-IN-1 is a potent and orally active dual *JAK2/FLT3* inhibitor with IC₅₀ values of 0.7 nM, 4 nM, 26 nM and 39 nM for JAK2, FLT3, JAK1 and JAK3, respectively. JAK2/FLT3-IN-1 has anti-cancer activity .

HY-130247A

Flonoltinib TFA 1 Publications Verification JAK2/Flt3-IN-1 TFA	JAK FLT3 Apoptosis	Cancer
JAK2/FLT3-IN-1 (TFA) is a potent and orally active dual *JAK2/FLT3* inhibitor with IC₅₀ values of 0.7 nM, 4 nM, 26 nM and 39 nM for JAK2, FLT3, JAK1 and JAK3, respectively. JAK2/FLT3-IN-1 (TFA) has anti-cancer activity .

Cat. No.	Product Name

HY-L079

Anti-Blood Cancer Compound Library

2,897 compounds

Blood cancers, also called hematologic cancers, occur when abnormal blood cells start growing out of control, interrupting the function of normal blood cells, which fight off infection and produce new blood cells. Most blood cancers start in the bone marrow, which is where blood is produced. There are three main types of blood cancers: leukemia, lymphoma and myeloma, which afflict millions of children and adults every year, and are often deadly.

Some common blood cancer treatments include stem cell transplantation, chemotherapy, radiation therapy, targeted therapy, immunotherapy or a combination thereof. As we begin to understand the key signaling pathways and molecular drivers of malignant transformation in haematological disorders, new treatment strategies will continue to be developed.

MCE offers a unique collection of 2,897 compounds with identified and potential anti-blood cancer activity. These compounds target blood cancer’s major targets and signaling pathways. MCE anti-blood cancer compound library is a useful tool for anti-blood cancer drugs screening and other related research.

Cat. No.	Product Name	Type

HY-50751G

Linifanib (GMP)

ABT-869 (GMP); AL-39324 (GMP)

Fluorescent Dye

Linifanib (ABT-869) (GMP) is Linifanib (HY-50751) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Linifanib is a potent and orally active multi-target inhibitor of VEGFR and PDGFR family with IC₅₀s of 4, 3, 66, and 4 nM for KDR, FLT1, PDGFRβ, and FLT3, respectively. Linifanib (GMP) promotes the generation and reprogramming of iPSCs from somatic cells .

Cat. No.	Product Name	Type

HY-50751G

Linifanib (GMP)

ABT-869 (GMP); AL-39324 (GMP)

Biochemical Assay Reagents

Cat. No.	Product Name	Target	Research Area

HY-P5438

Srctide	Peptides	Others
Srctide is a biological active peptide. (This is a peptide substrate for many protein kinases, such as Blk, BTK, cKit, EPHA1, EPHB2, EPHB3, ERBB4, FAK, Flt3, IGF-1R, ITK, Lck, MET, MUSK, Ret, Src, TIE2, TrkB, VEGF-R1 (Flt-1) and VEGF-R2 (KDR).)

HY-P5527F

FAM-CSKtide	Peptides	Others
FAM-CSKtide is a biological active peptide. (This is a FAM labeled peptide substrate (Abs/Em = 494/521 nm) for C-terminal Src kinase (Csk) and many other kinases such as Axl, cKit, ERBB4, Fes, Flt3, IGF-1 R, MET, MUSK, PYK2, Ret, TIE2, TrkA, VEGF-R1 and VEGF-R2.)

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-107417

Hypothemycin	Structural Classification Monophenols Microorganisms Antifungal Macrolide Antibiotics Classification of Application Fields Antibiotics Source classification Phenols Disease Research Disease Research Fields Cancer	VEGFR MEK FLT3 PDGFR ERK
Hypothemycin, a fungal polyketide, is a multikinase inhibitor with K_is of 10/70 nM, 17/38 nM, 90 nM, 900 nM/1.5 μM, and 8.4/2.4 μM for VEGFR2/VEGFR1, MEK1/MEK2, *FLT-3, PDGFRβ/PDGFRα, and ERK1/ERK2*, respectively .

HY-N0071

Crotonoside Isoguanosine	Alkaloids Structural Classification Classification of Application Fields Other Alkaloids Croton tiglium Linn. Source classification Euphorbiaceae Plants Disease Research Fields Cancer	FLT3 HDAC
Crotonoside is isolated from Chinese medicinal herb, Croton. Crotonoside inhibits *FLT3* and *HDAC3/6*, exhibits selective inhibition in acute myeloid leukemia (AML) cells. Crotonoside could be a promising new lead compound for the research of AML .

HY-N10221

Petromurin C	Alkaloids Monophenols Microorganisms Classification of Application Fields Source classification Phenols Disease Research Fields Indole Alkaloids Cancer	Apoptosis
Petromurin C is a bisindolylbenzenoid compound isolated from the ascostromata of Petromycesmuricatus. Petromurin C induces protective autophagy and apoptosis in FLT3-ITD-positive AML .

Recombinant Proteins Recommended:

Flt-3

Species:	Human (12) Rhesus Macaque (1) Mouse (5) Rat (1) Cynomolgus (1) Pig (1)
Tag:	His (13) Tag Free (3) Avi (2) Fc (5)
Source:	HEK293 (11) CHO (2) Sf9 insect cells (3) E. coli (5)

Cat. No.	Compare	Product Name	Species	Source

HY-P75184

	FLT3 Protein, Human (HEK293, hFc) CD135; FL cytokine receptor; FLK2; Flk-2; Flt-3; STK-1	Human	HEK293
	FLT3 is a tyrosine-protein kinase receptor that regulates differentiation, proliferation, and survival of hematopoietic progenitor cells and dendritic cells. It phosphorylates downstream effectors such as SHC1 and AKT1, activating signaling cascades involving MTOR, RAS, and MAP kinases. FLT3 Protein, Human (HEK293, hFc) is the recombinant human-derived FLT3 protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P74151

	FLT3 Protein, Mouse (HEK293, His) CD135; FL cytokine receptor; FLK2; Flk-2; Flt-3; STK-1	Mouse	HEK293
	FLT3, a receptor tyrosine kinase, has diverse functions including kinase activation, PI3K binding, and ligase binding. It plays a vital role in hematopoiesis, immune function, and tissue development. FLT3 is expressed in various tissues like the brain, immune system, and reproductive system. It is involved in diseases like leukemia and cancer. The wide functions and tissue-specific expression emphasize FLT3's importance in health and disease. FLT3 Protein, Mouse (HEK293, His) is the recombinant mouse-derived FLT3 protein, expressed by HEK293 , with C-His labeled tag.

HY-P75183

	FLT3 Protein, Human (T227M, HEK293, His) CD135; FL cytokine receptor; FLK2; Flk-2; Flt-3; STK-1	Human	HEK293
	FLT3 is a tyrosine-protein kinase receptor that regulates differentiation, proliferation, and survival of hematopoietic progenitor cells and dendritic cells. It phosphorylates downstream effectors such as SHC1 and AKT1, activating signaling cascades involving MTOR, RAS, and MAP kinases. FLT3 Protein, Human (T227M, HEK293, His) is the recombinant human-derived FLT3 protein, expressed by HEK293 , with C-His labeled tag.

HY-P70178

	FLT3 Protein, Human (HEK293, hFc, solution) 2 Publications Verification rHuReceptor-Type Tyrosine-Protein Kinase Flt3/Flt3, Fc; Receptor-Type Tyrosine-Protein Kinase Flt3; FL Cytokine Receptor; Fetal Liver Kinase-2; FLK-2; Fms-Like Tyrosine Kinase 3; Flt-3; Stem Cell Tyrosine Kinase 1; STK-1; CD135; Flt3; FLK2; STK1	Human	HEK293
	FLT3 is a tyrosine-protein kinase receptor that regulates differentiation, proliferation, and survival of hematopoietic progenitor cells and dendritic cells. It phosphorylates downstream effectors such as SHC1 and AKT1, activating signaling cascades involving MTOR, RAS, and MAP kinases. FLT3 Protein, Human (HEK293, Fc, solution) is the recombinant human-derived FLT3 protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P72802

	FLT3LG Protein, Macaca nemestrina Fms related receptor tyrosine kinase 3 ligand; Flt3LG; Flt-3 Ligand	Rhesus Macaque	E. coli
	FLT3LG Proteinas, a potent stimulator of early hematopoietic cell proliferation, activates FLT3 and synergizes with colony-stimulating factors and interleukins. As a homodimer, especially in isoform 2, it crucially promotes expansion and differentiation of hematopoietic progenitor cells. FLT3LG's collaborative signaling with other molecules underscores its significance in regulating hematopoiesis and maintaining hematopoietic system balance. FLT3LG Protein, Macaca nemestrina is the recombinant Rhesus Macaque-derived FLT3LG protein, expressed by E. coli , with tag free. The total length of FLT3LG Protein, Macaca nemestrina is 159 a.a., with molecular weight of ~18.0 kDa.

HY-P7111

	FLT3LG Protein, Human (CHO) 1 Publications Verification rHuFlt-3 Ligand; Flt3 ligand; FL; SL cytokine; Flt-3L	Human	CHO
	FLT3LG Protein, Human (CHO) is a cytokine, which can promote the generation and differentiation of hematopoietic stem cells and their progenitor cells.

HY-P70544

	FLT3LG Protein, Human (HEK293, His) Fms-Felated Tyrosine Kinase 3 Ligand; Flt3 Ligand; Flt3L; SL Cytokine; Flt3LG	Human	HEK293
	FLT3LG Proteinas, a potent stimulator of early hematopoietic cell proliferation, activates FLT3 and synergizes with colony-stimulating factors and interleukins. As a homodimer, especially in isoform 2, it crucially promotes expansion and differentiation of hematopoietic progenitor cells. FLT3LG's collaborative signaling with other molecules underscores its significance in regulating hematopoiesis and maintaining hematopoietic system balance. FLT3LG Protein, Human (HEK293, His) is the recombinant human-derived FLT3LG protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P700072

	FLT3LG Protein, Human (Tag Free) Flt-3 Ligand; Flt3 ligand; FL; SL cytokine; Flt-3L	Human	E. coli
	FLT3LG Proteinas, a potent stimulator of early hematopoietic cell proliferation, activates FLT3 and synergizes with colony-stimulating factors and interleukins. As a homodimer, especially in isoform 2, it crucially promotes expansion and differentiation of hematopoietic progenitor cells. FLT3LG's collaborative signaling with other molecules underscores its significance in regulating hematopoiesis and maintaining hematopoietic system balance. FLT3LG Protein, Human (Tag Free) is the recombinant human-derived FLT3LG protein, expressed by E. coli, with tag free. The total length of FLT3LG Protein, Human (Tag Free) is 155 a.a., with molecular weight of ~17.61 kDa.

HY-P700722

	FLT3 Protein, Cynomolgus (HEK293, hFc) CD135; FLK2; STK-1; Flt-3	Cynomolgus	HEK293
	FLT3 is a tyrosine-protein kinase receptor that regulates differentiation, proliferation, and survival of hematopoietic progenitor cells and dendritic cells. It phosphorylates downstream effectors such as SHC1 and AKT1, activating signaling cascades involving MTOR, RAS, and MAP kinases. FLT3 Protein, Cynomolgus (HEK293, hFc) is the recombinant cynomolgus-derived FLT3 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of FLT3 Protein, Cynomolgus (HEK293, hFc) is 514 a.a., with molecular weight of 160-180 kDa.

HY-P78444

	FLT3 Protein, Human (HEK293, His-Avi) CD135; FLK2; STK-1; Flt-3	Human	HEK293
	FLT3 is a tyrosine-protein kinase receptor that regulates differentiation, proliferation, and survival of hematopoietic progenitor cells and dendritic cells. It phosphorylates downstream effectors such as SHC1 and AKT1, activating signaling cascades involving MTOR, RAS, and MAP kinases. FLT3 Protein, Human (HEK293, His-Avi) is the recombinant human-derived FLT3 protein, expressed by HEK293 , with C-His, C-Avi labeled tag.

HY-P73066

	FLT3LG Protein, Human (sf9, His) Fms-related tyrosine kinase 3 ligand; Flt3 Ligand; Flt3L; SL Cytokine; Flt3LG	Human	Sf9 insect cells
	FLT3LG Proteinas, a potent stimulator of early hematopoietic cell proliferation, activates FLT3 and synergizes with colony-stimulating factors and interleukins. As a homodimer, especially in isoform 2, it crucially promotes expansion and differentiation of hematopoietic progenitor cells. FLT3LG's collaborative signaling with other molecules underscores its significance in regulating hematopoiesis and maintaining hematopoietic system balance. FLT3LG Protein, Human (sf9, His) is the recombinant human-derived FLT3LG protein, expressed by Sf9 insect cells , with N-His labeled tag. The total length of FLT3LG Protein, Human (sf9, His) is 159 a.a., with molecular weight of ~27 kDa.

HY-P73067

	FLT3LG Protein, Mouse (HEK293, Fc) Fms-related tyrosine kinase 3 ligand; Flt3 Ligand; Flt3L; SL Cytokine; Flt3LG	Mouse	HEK293
	FLT3LG Proteinas, a potent stimulator, activates FLT3, synergizing with colony-stimulating factors and interleukins. Its homodimeric form, especially in the soluble isoform, effectively promotes the expansion and differentiation of hematopoietic progenitor cells. The protein's significance lies in orchestrating key processes within the hematopoietic system. FLT3LG Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived FLT3LG protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P74150

	FLT3LG Protein, Rat (sf9, His) Fms-related tyrosine kinase 3 ligand; Flt3 Ligand; Flt3L; SL Cytokine; Flt3LG	Rat	Sf9 insect cells
	The FLT3LG protein has the same protein-binding and receptor tyrosine kinase-binding activities predicted to positively regulate natural killer cell proliferation. Intended to be located on the cell surface and extracellular space, it serves as an intrinsic component on the outside of the plasma membrane. FLT3LG Protein, Rat (sf9, His) is the recombinant rat-derived FLT3LG protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of FLT3LG Protein, Rat (sf9, His) is 162 a.a., with molecular weight of ~19.7 kDa.

HY-P70563

	FLT3LG Protein, Mouse (HEK293, His) Fms-related tyrosine kinase 3 ligand (Flt3L); SL cytokine; Flt3 ligand;	Mouse	HEK293
	FLT3LG Proteinas, a potent stimulator, activates FLT3, synergizing with colony-stimulating factors and interleukins. Its homodimeric form, especially in the soluble isoform, effectively promotes the expansion and differentiation of hematopoietic progenitor cells. The protein's significance lies in orchestrating key processes within the hematopoietic system. FLT3LG Protein, Mouse (HEK293, His) is the recombinant mouse-derived FLT3LG protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P702754

	FLT3 Protein, Human (Biotinylated, sf9, His, Avi) Flt3; fms-related tyrosine kinase 3; receptor-type tyrosine-protein kinase Flt3; CD135; FLK2; STK1; STK-1; CD135 antigen; FL cytokine receptor; fetal liver kinase 2; fms-like tyrosine kinase 3; stem cell tyrosine kinase 1; growth factor receptor tyrosine kinase type III; FLK-2	Human	Sf9 insect cells
	FLT3 is a tyrosine-protein kinase receptor that regulates differentiation, proliferation, and survival of hematopoietic progenitor cells and dendritic cells. It phosphorylates downstream effectors such as SHC1 and AKT1, activating signaling cascades involving MTOR, RAS, and MAP kinases. FLT3 Protein, Human (Biotinylated, sf9, His, Avi) is the recombinant human-derived FLT3, expressed by Sf9 insect cells , with Avi, His labeled tag. The total length of FLT3 Protein, Human (Biotinylated, sf9, His, Avi) is 370 a.a.,

HY-P7354

	FLT3LG Protein, Mouse (CHO, His) rMuFlt-3 Ligand, His; Fms-related tyrosine kinase 3 ligand; SL cytokine; Flt3lg	Mouse	CHO
	FLT3LG Protein, Mouse (CHO, His) is a ligand of mouse Flt-3, induces proliferation of haematopoietic progenitor cells.

HY-P701290

	*FITC-Labeled FLT3* Protein, Human (HEK293, Fc)** Flt-3; Flk-2; STK-1; CD135; FLK2; Flt-3	Human	HEK293
	FLT3 is a tyrosine-protein kinase receptor that regulates differentiation, proliferation, and survival of hematopoietic progenitor cells and dendritic cells. It phosphorylates downstream effectors such as SHC1 and AKT1, activating signaling cascades involving MTOR, RAS, and MAP kinases. FITC-Labeled FLT3 Protein, Human (HEK293, Fc) is the recombinant human-derived FITC-Labeled FLT3 protein, expressed by HEK293 , with Fc labeled tag.

HY-P700072AF

	*Animal-Free FLT3LG Protein, Human (His)* Flt-3 Ligand; Flt3 ligand; FL; SL cytokine; Flt-3L	Human	E. coli
	FLT3LG Proteinas, a potent stimulator of early hematopoietic cell proliferation, activates FLT3 and synergizes with colony-stimulating factors and interleukins. As a homodimer, especially in isoform 2, it crucially promotes expansion and differentiation of hematopoietic progenitor cells. FLT3LG's collaborative signaling with other molecules underscores its significance in regulating hematopoiesis and maintaining hematopoietic system balance. Animal-Free FLT3LG Protein, Human (His) is the recombinant human-derived animal-FreeFLT3LG protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free FLT3LG Protein, Human (His) is 155 a.a., with molecular weight of ~18.6 kDa.

HY-P700238AF

	*Animal-Free FLT3LG Protein, Pig (His)* Fms-Felated Tyrosine Kinase 3 Ligand; Flt3 Ligand; Flt3L; SL Cytokine; Flt3LG	Pig	E. coli
	Animal-Free FLT3LG Protein, Pig (His) is the recombinant pig-derived animal-FreeFlt-3 Ligand protein, expressed by E. coli , with C-His labeled tag.

HY-P70544G

	*GMP FLT3LG Protein, Human (HEK293, His)* Fms-related tyrosine kinase 3 ligand; Flt3L; SL cytokine; Flt3LG	Human	HEK293
	FLT3LG Proteinas, a potent stimulator of early hematopoietic cell proliferation, activates FLT3 and synergizes with colony-stimulating factors and interleukins. As a homodimer, especially in isoform 2, it crucially promotes expansion and differentiation of hematopoietic progenitor cells. FLT3LG's collaborative signaling with other molecules underscores its significance in regulating hematopoiesis and maintaining hematopoietic system balance. GMP FLT3LG Protein, Human (HEK293, His) is the recombinant human-derived FLT3LG protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P700177AF

	*Animal-Free FLT3LG Protein, Mouse (His)* rMuFlt-3 Ligand, His; Fms-related tyrosine kinase 3 ligand; SL cytokine; Flt3lg	Mouse	E. coli
	FLT3LG Proteinas, a potent stimulator, activates FLT3, synergizing with colony-stimulating factors and interleukins. Its homodimeric form, especially in the soluble isoform, effectively promotes the expansion and differentiation of hematopoietic progenitor cells. The protein's significance lies in orchestrating key processes within the hematopoietic system. Animal-Free FLT3LG Protein, Mouse (His) is the recombinant mouse-derived animal-FreeFLT3LG protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free FLT3LG Protein, Mouse (His) is 162 a.a., with molecular weight of ~19.3 kDa.

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Cat. No.	Product Name	Chemical Structure

HY-12432S1

Gilteritinib-d8
Gilteritinib-d₈ is deuterium labeled Gilteritinib. Gilteritinib (ASP2215) is a potent and ATP-competitive FLT3/AXL inhibitor with IC50s of 0.29 nM/0.73 nM, respectively.

HY-13016S

Cabozantinib-d6
Cabozantinib-d₆ is the deuterium labeled Cabozantinib. Cabozantinib is a potent multiple receptor tyrosine kinases (RTKs) inhibitor that inhibits VEGFR2, c-Met, Kit, Axl and Flt3 with IC50s of 0.035, 1.3, 4.6, 7 and 11.3 nM, respectively[1][2][3].

HY-10230S

Midostaurin-d5
Midostaurin-d₅ is a deuterium labeled Midostaurin. Midostaurin is a multi-targeted protein kinase inhibitor which inhibits PKCα/β/γ, Syk, Flk-1, Akt, PKA, c-Kit, c-Fgr, c-Src, FLT3, PDFRβ and VEGFR1/2 with IC50s ranging from 22-500 nM[1].

HY-10201S2

Sorafenib-13C,d3

1 Publications Verification

Sorafenib- ¹³C,d₃ is the ¹³C- and deuterium labeled Sorafenib. Sorafenib (Bay 43-9006) is a potent and orally active Raf inhibitor with IC50s of 6 nM and 20 nM for Raf-1 and B-Raf, respectively. Sorafenib is a multikinase inhibitor with IC50s of 90 nM, 15 nM, 20 nM, 57 nM and 58 nM for VEGFR2, VEGFR3, PDGFRβ, FLT3 and c-Kit, respectively. Sorafenib induces autophagy and apoptosis. Sorafenib has anti-tumor activity. Sorafenib is a ferroptosis activator[1].

HY-148036S

FLT3-IN-16-d1
FLT3-IN-16-d1 is the deuterium labeled FLT3-IN-16 (HY-148036). FLT3-IN-16 is a potent *FLT3* inhibitor with an IC₅₀ of 1.1 μM. FLT3-IN-16 can be used for researching acute myeloid leukemia .

HY-13016S1

Cabozantinib-d4
Cabozantinib-d₄ is deuterium labeled Cabozantinib. Cabozantinib is a potent multiple receptor tyrosine kinases (RTKs) inhibitor that inhibits VEGFR2, c-Met, Kit, Axl and Flt3 with IC50s of 0.035, 1.3, 4.6, 7 and 11.3 nM, respectively.

HY-108263S

3-Hydroxy Midostaurin-d5
3-Hydroxy Midostaurin-d₅ is a deuterium labeled 3-Hydroxy Midostaurin. 3-Hydroxy Midostaurin is a metabolite of PKC412, which effectively inhibits FMS-like tyrosine kinase-3 (FLT3) autophosphorylation with IC50s of approximately 132 nM and 9.8 μM in culture medium and plasma, respectively[1].

HY-50905S

Dovitinib-d8
Dovitinib-d₈ is the deuterium labeled Dovitinib. Dovitinib (CHIR-258) is a multi-targeted tyrosine kinase inhibitor with IC50s of 1, 2, 8/9, 10/13/8, 27/210 nM for FLT3, c-Kit, FGFR1/FGFR3, VEGFR1/VEGFR2/VEGFR3 and PDGFRα/PDGFRβ, respectively[1][2].

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