Search Result

Results for "

HS

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Linker (3) Akt (2) Apoptosis (4) Autophagy (1) Bacterial (1) Bcr-Abl (1) Biochemical Assay Reagents (2) c-Met/HGFR (3) Carbonic Anhydrase (1) Casein Kinase (1) CD20 (1) CDK (1) CXCR (1) DAPK (4) Drug-Linker Conjugates for ADC (1) EGFR (4) Endogenous Metabolite (1) Fatty Acid Synthase (FASN) (2) FBPase (1) FGFR (2) Fluorescent Dye (1) HBV (2) Histamine Receptor (4) HIV (1) HSP (2) HSV (2) IRAK (3) LPL Receptor (7) MEK (1) Melanocortin Receptor (4) MMP (1) nAChR (1) Notch (1) PD-1/PD-L1 (1) Phosphodiesterase (PDE) (1) PI3K (2) Pim (1) Prostaglandin Receptor (1) PROTAC Linkers (22) RIP kinase (1) ROS Kinase (1) SGLT (1) Small Interfering RNA (siRNA) (10) TNF Receptor (1) Transferrin Receptor (1) Trk Receptor (1) VEGFR (2)
By Research Areas:	Cancer (52) Cardiovascular Disease (4) Endocrinology (9) Infection (6) Inflammation/Immunology (18) Metabolic Disease (5) Neurological Disease (14)
Click Chemistry:	PROTAC Synthesis (3) Azide (3) BCN (2)
Oligonucleotides:	Pre-designed siRNA Sets (10) Adjuvant (5) siRNAs (10)

101

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-129156

HS-1793	Apoptosis	Cancer
HS-1793 is a Resveratrol (HY-16561) analogue with antitumor activities in a variety of cancer cell lines . HS-1793 induces cell apoptosis .

HY-134911

HS-243	IRAK CDK	Inflammation/Immunology Cancer
HS-243 is a potent and selective IRAK-4 and IRAK-1 inhibitor, with IC₅₀ values of 20 and 24 nM. HS-243 shows minimal TAK1 (transforming growth factor β-activated kinase 1) inhibition activity, with a IC₅₀ of 0.5 μM. HS-243 shows anti-inflammatory and anticancer activity .

HY-130851

HS-27	HSP	Cancer
HS-27, a fluorescently-tethered Hsp90 inhibitor, assays surface Hsp90 expression on intact tissue specimens. HS-27 is made up of the core elements of SNX-5422, an Hsp90 inhibitor, tethered via a PEG linker to a fluorescein derivative (fluorescein isothiocyanate or FITC), that binds to ectopically expressed Hsp90. HS-27 has potential use in a see-and-treat paradigm in breast cancer .

HY-15868

HS-173 5 Publications Verification	PI3K Apoptosis	Cancer
HS-173 is a novel PI3K inhibitor, that is used for cancer treatment.

HY-123486

HS-438	Apoptosis Bcr-Abl	Cancer
HS-438 is a potent and selective BCR-ABL inhibitor. HS-438 shows antiproliferative activity. HS-438 decreases the expression of phosphorylation of BCR-ABL (Tyr177). HS-438 induces apoptosis and cell cycle arrest at G0/G1 phase. HS-438 shows antitumor activity. HS-438 has the potential for the research of chronic myeloid leukemia (CML) .

HY-164483

HS-345	Akt Trk Receptor	Cancer
HS-345 is a TrkA/Ak inhibitor with significant anti-pancreatic cancer effects. HS-345 inhibits the growth and proliferation of pancreatic cancer cells by targeting the TrkA/Akt signaling pathway, while also inducing apoptosis. Additionally, HS-345 suppresses blood vessel formation by decreasing the expression of HIF-1α and VEGF. HS-345 holds promise for research in pancreatic cancer .

HY-112522

HS79	Fatty Acid Synthase (FASN)	Cancer
HS-79 is an enantiomer of Fasnall, which is a selective fatty acid synthase (FASN) inhibitor. HS-79 is able to inhibit the incorporation of tritiated acetate into lipids with an IC₅₀ of 1.57 μM.

HY-112522A

HS80	Fatty Acid Synthase (FASN)	Cancer
HS-80 is an enantiomer of Fasnall, which is a selective fatty acid synthase (FASN) inhibitor. HS-80 is able to inhibit the incorporation of tritiated acetate into lipids with an IC₅₀ of 7.13 μM.

HY-157084

HS-291	ROS Kinase Bacterial	Infection
HS-291 is a HtpG inhibitor of Borrelia burgdorferi (Bb). HS-291 contains BX-2819 (high affinity for Bb HtpG), PEG linker, and Verteporfin (HY-B0146) (a photoactive toxin).HS-291 produces reactive oxygen species under light activation to oxidize HtpG and a discrete protein subset near chaperone proteins and can quickly and irreversibly inactivate Bb .

HY-120040

HS94	DAPK	Cardiovascular Disease
HS94 is a selective DAPK3 inhibitor. HS94 can be used for research of hypertension .

HY-147141

HS-276	IRAK TNF Receptor Casein Kinase	Inflammation/Immunology
HS-276 is an orally active, potent and highly selective TAK1 inhibitor, with a K_i of 2.5 nM. HS-276 shows significant inhibition of TAK1, CLK2, GCK, ULK2, MAP4K5, IRAK1, NUAK, CSNK1G2, CAMKKβ-1, and MLK1, with IC₅₀ values of 8.25, 29, 33, 63, 125, 264, 270, 810, 1280, and 5585 nM, respectively. HS-276 can be used for rheumatoid arthritis (RA) research .

HY-114349

HS-1371 1 Publications Verification	RIP kinase	Cardiovascular Disease Cancer
HS-1371 is a potent and ATP-competitive receptor-interacting protein kinase 3 (RIP3) inhibitor with an IC₅₀ of 20.8 nM .

HY-123983

HS56	Pim DAPK	Cardiovascular Disease
HS56 is an ATP-competitive dual Pim/DAPK3 inhibitor with K_i values of 0.26, 0.208, 2.94, and ＞100 μM for DAPK3, Pim-3, Pim-1, and Pim-2, respectively. HS56 inhibits LC20 phosphorylation and smooth muscle contraction. HS56 decreases blood pressure in spontaneously hypertensive mice. HS56 can be used in research of hypertension .

HY-15847

HS38 1 Publications Verification	DAPK	Cardiovascular Disease
HS38 is a potent, selective, and ATP-competitive inhibitor of death-associated protein kinase 1 (DAPK1) and zipper-interacting protein kinase (ZIPK, also called DAPK3), with K_ds of 300 nM and 280 nM, respectively. HS38 is also a PIM3 inhibitor with an IC₅₀ of 200 nM. HS38 can be used for the research of smooth muscle related disorders .

HY-122878

HS-131	HSP	Cancer
HS-131, a near infrared dye tethered Hsp90 inhibitor, is able to detect oncogene-driven breast cancers, including multiple different molecular subtypes of human breast cancers .

HY-131903

HS271	IRAK	Inflammation/Immunology
HS271 is a highly potent, orally active and selective IRAK4 inhibitor, with an IC₅₀ of 7.2 μM. HS271 exhibits superior enzymatic and cellular activities, as well as excellent pharmacokinetic properties .

HY-P1216

HS014	Melanocortin Receptor	Neurological Disease
HS014 is a potent and selective melanocortin-4 (MC4) receptor antagonist, with K_is of 3.16, 108, 54.4 and 694 nM for human MC4, MC1, MC3 and MC5 receptors, respectively. HS014 modulates the behavioral effects of morphine in mice. HS014 increases food intake in free-feeding rats .

HY-P1215

HS024	Melanocortin Receptor	Metabolic Disease
HS024 is a selective MC4 receptor antagonist, with K_is of 0.29, 3.29, 5.45, and 18.6 nM for MC4, MC5, MC3, and MC1, respectively. HS024 increase food intake .

HY-117364

HS148	DAPK	Others
HS148 (compound 22) is a selective DAPK3 inhibitor with an K_i value of 119 nM .

HY-137453

Tenofovir amibufenamide HS-10234	HBV	Infection
Tenofovir amibufenamide (HS-10234), a Tenofovir prodrug, is an orally active antiviral agent. Tenofovir amibufenamide inhibits HBV, and can be used for chronic hepatitis B (CHB) study .

HY-P1215A

HS024 TFA	Melanocortin Receptor	Metabolic Disease
HS024 is a selective MC4 receptor antagonist, with K_is of 0.29, 3.29, 5.45, 18.6 nM for MC4, MC5, MC3, and MC1, respectively. HS024 increase food intake .

HY-145485

HS-PEG-SH (MW 3400)	Biochemical Assay Reagents	Others
HS-PEG-SH (MW 3400), a linear homobifunctional PEG, is a cross-linker. HS-PEG-SH can be used for drug delivery and preparation of PEG hydrogels .

HY-B0298A

Clemastine fumarate 5+ Cited Publications HS-592 fumarate; Meclastine fumarate	Histamine Receptor	Neurological Disease Endocrinology
Clemastine (HS-592) fumarate is a selective histamine H1 receptor antagonist. Clemastine fumarate is an antihistamine mainly used for relieving symptoms of allergic reactions primarily by competing with histamine to bind H1 receptors. Anti-inflammatory effects .

HY-B0298

Clemastine HS-592; Meclastine	Histamine Receptor	Neurological Disease
Clemastine (HS-592) is a potent and orally active histamine receptor H1 antagonist. Clemastine is an antihistamine mainly used for relieving symptoms of allergic reactions primarily by competing with histamine to bind H1 receptors. Anti-inflammatory effects .

HY-P1216A

HS014 TFA	Melanocortin Receptor	Neurological Disease
HS014 TFA is a potent and selective melanocortin-4 (MC4) receptor antagonist, with K_is of 3.16, 108, 54.4 and 694 nM for human MC4, MC1, MC3 and MC5 receptors respectively. HS014 TFA increases food intake in free-feeding rats .

HY-P99501

Zuberitamab HS006	CD20	Cancer
Zuberitamab (HS006) is a monoclonal antibody that targets CD20 and can be used in cancer research, including diffuse large B-cell lymphoma .

HY-B0298AS

Clemastine-d5 fumarate 1 Publications Verification HS-592-d5 (fumarate); Meclastine-d5 (fumarate)	Histamine Receptor Autophagy	Neurological Disease Endocrinology
Clemastine-d₅ (fumarate) is the deuterium labeled Clemastine fumarate. Clemastine fumarate (HS-592 fumarate) is a selective histamine H1 receptor antagonist with IC50 of 3 nM.

HY-133387

HS-C6-PEG9-acid	PROTAC Linkers	Cancer
HS-C6-PEG9-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .

HY-B0298AR

Clemastine fumarate (Standard) HS-592 fumarate (Standard); Meclastine fumarate (Standard)	Histamine Receptor	Neurological Disease Endocrinology
Clemastine (fumarate) (Standard) is the analytical standard of Clemastine (fumarate). This product is intended for research and analytical applications. Clemastine (HS-592) fumarate is a selective histamine H1 receptor antagonist. Clemastine fumarate is an antihistamine mainly used for relieving symptoms of allergic reactions primarily by competing with histamine to bind H1 receptors. Anti-inflammatory effects .

HY-112823B

Almonertinib hydrochloride 3 Publications Verification HS-10296 hydrochloride	EGFR	Cancer
Almonertinib (HS-10296) hydrochloride is an orally available, irreversible, third-generation EGFR tyrosine kinase inhibitor with high selectivity for EGFR-sensitizing and T790M resistance mutations. Almonertinib hydrochloride shows great inhibitory activity against T790M, T790M/L858R and T790M/Del19 (IC₅₀: 0.37, 0.29 and 0.21 nM, respectively), and is less effective against wild type (3.39 nM). Almonertinib hydrochloride is used for the research of the non-small cell lung cancer .

HY-112823

Almonertinib 3 Publications Verification HS-10296	EGFR	Cancer
Almonertinib (HS-10296) is an orally available, irreversible, third-generation EGFR tyrosine kinase inhibitor with high selectivity for EGFR-sensitizing and T790M resistance mutations. Almonertinib shows great inhibitory activity against T790M, T790M/L858R and T790M/Del19 (IC₅₀: 0.37, 0.29 and 0.21 nM, respectively), and is less effective against wild type (3.39 nM). Almonertinib is used for the research of the non-small cell lung cancer .

HY-112823A

Almonertinib mesylate 3 Publications Verification HS-10296 mesylate	EGFR	Cancer
Almonertinib (HS-10296) mesylate is an orally available, irreversible, third-generation EGFR tyrosine kinase inhibitor with high selectivity for EGFR-sensitizing and T790M resistance mutations. Almonertinib mesylate shows great inhibitory activity against T790M, T790M/L858R and T790M/Del19 (IC₅₀: 0.37, 0.29 and 0.21 nM, respectively), and is less effective against wild type (3.39 nM). Almonertinib mesylate is used for the research of the non-small cell lung cancer .

HY-RS06375

HS1BP3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
HS1BP3 Human Pre-designed siRNA Set A contains three designed siRNAs for HS1BP3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HS1BP3 Human Pre-designed siRNA Set A HS1BP3 Human Pre-designed siRNA Set A

HY-RS06376

HS2ST1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
HS2ST1 Human Pre-designed siRNA Set A contains three designed siRNAs for HS2ST1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HS2ST1 Human Pre-designed siRNA Set A HS2ST1 Human Pre-designed siRNA Set A

HY-RS06377

HS3ST1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
HS3ST1 Human Pre-designed siRNA Set A contains three designed siRNAs for HS3ST1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HS3ST1 Human Pre-designed siRNA Set A HS3ST1 Human Pre-designed siRNA Set A

HY-RS06378

HS3ST2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
HS3ST2 Human Pre-designed siRNA Set A contains three designed siRNAs for HS3ST2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HS3ST2 Human Pre-designed siRNA Set A HS3ST2 Human Pre-designed siRNA Set A

HY-RS06380

HS3ST4 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
HS3ST4 Human Pre-designed siRNA Set A contains three designed siRNAs for HS3ST4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HS3ST4 Human Pre-designed siRNA Set A HS3ST4 Human Pre-designed siRNA Set A

HY-RS06381

HS3ST5 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
HS3ST5 Human Pre-designed siRNA Set A contains three designed siRNAs for HS3ST5 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HS3ST5 Human Pre-designed siRNA Set A HS3ST5 Human Pre-designed siRNA Set A

HY-RS06382

HS6ST1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
HS6ST1 Human Pre-designed siRNA Set A contains three designed siRNAs for HS6ST1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HS6ST1 Human Pre-designed siRNA Set A HS6ST1 Human Pre-designed siRNA Set A

HY-RS06383

HS6ST2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
HS6ST2 Human Pre-designed siRNA Set A contains three designed siRNAs for HS6ST2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HS6ST2 Human Pre-designed siRNA Set A HS6ST2 Human Pre-designed siRNA Set A

HY-RS06384

HS6ST3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
HS6ST3 Human Pre-designed siRNA Set A contains three designed siRNAs for HS6ST3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HS6ST3 Human Pre-designed siRNA Set A HS6ST3 Human Pre-designed siRNA Set A

HY-RS06379

HS3ST3B1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
HS3ST3B1 Human Pre-designed siRNA Set A contains three designed siRNAs for HS3ST3B1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HS3ST3B1 Human Pre-designed siRNA Set A HS3ST3B1 Human Pre-designed siRNA Set A

HY-130881

HS-PEG6-CH2CH2-Boc	PROTAC Linkers	Cancer
HS-PEG6-CH2CH2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .

HY-P99963

Sudubrilimab HS636	PD-1/PD-L1	Cancer
Sudubrilimab (HS636) is an Ig G1-kappa monoclonal antibody against PDL1. Sudubrilimab is fused at the C terminus of the heavy chain to a TGF-β1 receptor Ⅱ ectodomain (TGFBR2-ECD), and which can sequester the PD-1/PD-L1 pathway and TGF-β bioactivity in the immunosuppressive tumor microenvironment .

HY-130878

HS-PEG24-CH2CH2COOH Thiol-PEG24-acid	PROTAC Linkers	Cancer
HS-PEG24-CH2CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .

HY-130879

HS-PEG5-CH2CH2N3	PROTAC Linkers	Cancer
HS-PEG5-CH2CH2N3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . HS-PEG5-CH2CH2N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-130882

HS-PEG7-CH2CH2N3	PROTAC Linkers	Cancer
HS-PEG7-CH2CH2N3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . HS-PEG7-CH2CH2N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-130880

HS-PEG11-CH2CH2N3	PROTAC Linkers	Cancer
HS-PEG11-CH2CH2N3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . HS-PEG11-CH2CH2N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-130874

HS-PEG7-CH2CH2COOH Thiol-PEG7-propionic acid	PROTAC Linkers	Cancer
HS-PEG7-CH2CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .

HY-130875

HS-PEG9-CH2CH2COOH Thiol-PEG9-propionic acid	PROTAC Linkers	Cancer
HS-PEG9-CH2CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-108826

Iduronate sulfatase Iduronate sulfate sulfatase	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Iduronate sulfatase (Iduronate sulfate sulfatase) is an exo-sulfatase that hydrolyzes the C2-sulfate ester bond from nonreducing terminal α-L-iduronic acid residues in HS .

Cat. No.	Product Name	Chemical Structure