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SCLY

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (2) ADC Antibody (2) ADC Cytotoxin (2) ADC Linker (2) Akt (2) Aldose Reductase (1) Aminopeptidase (2) Androgen Receptor (3) Angiotensin Receptor (1) Antibiotic (7) Apical Sodium-Dependent Bile Acid Transporter (1) Apoptosis (14) Arenavirus (2) Autophagy (1) Bacterial (12) Caspase (1) Complement System (1) COX (13) Dengue virus (1) Dihydroorotate Dehydrogenase (1) Drug Metabolite (2) Drug-Linker Conjugates for ADC (3) EBV (1) EGFR (1) Endogenous Metabolite (3) Endonuclease (1) Epigenetic Reader Domain (1) Factor Xa (1) FLT3 (1) Fluorescent Dye (1) Fungal (3) FXR (1) HDAC (3) Herbicide (1) HIV (1) HIV Protease (1) IKK (1) Influenza Virus (1) Interleukin Related (4) JAK (1) Leukotriene Receptor (2) Liposome (2) MDM-2/p53 (2) Microtubule/Tubulin (1) Mineralocorticoid Receptor (2) MMP (1) Na+/K+ ATPase (1) NF-κB (1) Opioid Receptor (2) p38 MAPK (1) Parasite (2) Phosphatase (1) Phosphodiesterase (PDE) (1) Pim (1) PKC (2) Polo-like Kinase (PLK) (1) PPAR (1) Prostaglandin Receptor (6) PROTAC Linkers (1) Renin (1) SARS-CoV (1) Small Interfering RNA (siRNA) (3) STAT (3) TGF-β Receptor (1) VEGFR (1) Virus Protease (1) α-synuclein (1)
By Research Areas:	Cancer (51) Cardiovascular Disease (10) Endocrinology (4) Infection (24) Inflammation/Immunology (25) Metabolic Disease (3) Neurological Disease (14)
Click Chemistry:	DBCO (1)
Oligonucleotides:	Pre-designed siRNA Sets (2) Cationic Lipids (2) siRNAs (3) Sweetening Agents (1)

123

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
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Recombinant Proteins

Click Chemistry

Oligonucleotides

2-Phenyl-2-(2-pyridyl)acetonitrile α-Phenyl-2-pyridineacetonitrile	Drug Metabolite	Endocrinology
2-Phenyl-2-(2-pyridyl)acetonitrile is the major metabolite of SC 15396 metabolized by the supernatant fraction of rat liver homogenate. SC 15396 is an antigastrin that inhibits gastric secretion .

SC-43 4 Publications Verification	Phosphatase STAT Apoptosis	Cancer
SC-43, a Sorafenib derivative, is a potent and orally active SHP-1 (PTPN6) agonist. SC-43 inhibits the phosphorylation of STAT3 and induces cell apoptosis. SC-43 has anti-fibrotic and anticancer effects .

SC-58125	COX	Inflammation/Immunology Cancer
SC-58125 is a potent and selective inhibitor of cyclooxygenase 2 (COX-2), with an IC₅₀ of 0.04 μM. SC-58125 exhibits antitumor activity in vitro and in vivo. SC-58125 also can inhibit edema at the inflammatory site and has analgesic effect .

SC-19220	Prostaglandin Receptor	Others
SC-19220 is a competitive prostaglandinn E2 receptor antagonist. SC-19220 increases the bladder capacity and reduced the voiding efficiency of micturition (elicited by slow transvesical filling) of urethane-anesthetized rats. SC-19220 can restores the balance in bone marrow granulocyte and monocyte production after burn sepsis .

SC-51322	Prostaglandin Receptor	Neurological Disease
SC-51322 is a potent and selective antagonist of prostaglandin E2 (PGE₂) receptor (EP ₁), with a pA₂ of 8.1. SC-51322 has the pain-relieving effect .

SCLY Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SCLY Human Pre-designed siRNA Set A contains three designed siRNAs for SCLY gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

(Rac)-SC-45694	Others	Cancer
(Rac)-SC-45694 is a racemate of SC-45694. SC-45694 has full LTB4 agonist activity for neutrophil chemotaxis and has antagonist activity against LTB4-induced neutrophil degranulation .

SC-50605	Leukotriene Receptor	Inflammation/Immunology
SC-50605 and SC-51146 are second-generation leukotriene B4 (LTB4) receptor antagonists that effectively inhibit LTB4-induced chemotaxis in guinea pigs. SC-50605 targets the LTB4 receptor and has the potential to inhibit inflammatory diseases such as asthma, rheumatoid arthritis, and skin diseases. .

SC-41930	Leukotriene Receptor	Inflammation/Immunology
SC-41930 is a orally active eukotriene-B4 receptor antagonist. SC-41930 alleviates inflammation in guinea pig acetic acid-induced colonic inflammation model .

SC-55858	Others	Cardiovascular Disease
SC-55858 is an effective superoxide dismutase simulator. SC-55858 increased heart rate and decreased mean arterial pressure and left ventricular systolic and end-diastolic pressures in conscious dogs .

SC-22716	Aminopeptidase	Inflammation/Immunology
SC-22716 is a potent, competitive, reversible inhibitor of human LTA₄ hydrolase, with an IC₅₀ of 0.20 µM. SC-22716 has potential for the research of inflammatory bowel disease (IBD) and psoriasis .

SC-10	PKC	Cancer
SC-10 is a direct activator of PKC .

SC-23110	Bacterial	Infection
SC-23110 is a potent anti-acne agent. SC-23110 inhibits the growth of P. acnes, one of the organisms associated with acne, and most frequently mentioned as the organism involved in the pathogenesis of inflammatory pustules/lesions .

SC-435	Apical Sodium-Dependent Bile Acid Transporter	Metabolic Disease
SC-435 is an orally effective apical sodium codependent bile acid transporter (ASBT) inhibitor. SC-435 effectively removes neurotoxic bile acids and ammonia from the blood by inhibiting intestinal ASBT, thereby alleviating liver and brain damage caused by liver failure. SC-435 can alter hepatic cholesterol metabolism and lower plasma low-density lipoprotein-cholesterol concentrations .

Azacosterol dihydrochloride 20.25-Diazacholesterol dihydrochloride	Others	Endocrinology
Azacosterol (SC-12937) dihydrochloride is a chemosterilant which in-hibits reproduction in the pigeon. Azacosterol (SC-12937) dihydrochloride exerts its inhibitory effect through the blocking of the synthesis of cholesterol, thought to be a vital component in the formation of egg yolks .

SC 44914	Bacterial	Infection
SC 44914 is a quinoxaline compound with antibacterial effects. SC-44914 has activity against Campylobacter jejuni, C. coli, and Clostridium difficile .

4SC-203	FLT3 VEGFR	Cancer
4SC-203 is a potent multikinase inhibitor with potential antineoplastic activity. 4SC-203 selectively FLT3/STK1, FLT3 mutated forms, and VEGFRs .

SC-236 1 Publications Verification	COX PPAR Apoptosis	Cardiovascular Disease Inflammation/Immunology Cancer
SC-236 is an orally active COX-2 specific inhibitor (IC₅₀ = 10 nM) and a PPARγ agonist. SC-236 suppresses activator protein-1 (AP-1) through c-Jun NH2-terminal kinase. SC-236 exerts anti-inflammatory effects by suppressing phosphorylation of ERK in a murine model .

SC-75416	COX	Others
SC-75416 is a selective cyclooxygenase-2 inhibitor. Its pharmacokinetic/pharmacodynamic (PK/PD) model was used for development and clinical trial simulation to design a study protocol to verify its analgesic effect in a post-oral surgery pain model. The simulation results showed that 360 mg of SC-75416 may provide better pain relief than 400 mg of ibuprofen. The actual clinical trial results confirmed this hypothesis, and 360 mg of SC-75416 was indeed superior to 400 mg of ibuprofen in pain relief. The PK/PD model of SC-75416 showed good predictive performance and successfully predicted its clinical effect. These research results show that SC-75416, as a new selective COX-2 inhibitor, has potential clinical application value in the management of post-oral surgery pain.

SC-58272	Fungal	Infection
SC-58272 is a potent and selective dipeptide N-myristoyltransferase (Nmt) inhibitor with an IC₅₀ of 56 nM for C. albicans (strain B311) Nmt. SC-58272 shows 250-fold selective for the fungal enzyme compared to human enzyme .

SC-51316	Angiotensin Receptor	Cardiovascular Disease
SC-51316 is an oral active angiotensin II receptor antagonist with the IC₅₀ values of 3.6 and 5.1 nM in rat adrenal cortical and rat uterine membrane, respectively. SC-51316 shows antihypertensive activity in vivo and in vitro .

SC-9 NCM 119	PKC	Endocrinology Cancer
SC-9 is a PKC activator in the presence of Ca ²⁺ .

SC-560 2 Publications Verification	COX	Cancer
SC-560 is a potent and selective COX-1 inhibitor with an IC₅₀ of 9 nM.

Droxinavir hydrochloride SC-55389A	HIV	Infection
Droxinavir (SC-55389A) hydrochloride is an antiviral compound that functions as an HIV protease inhibitor.

SC209 intermediate-2	ADC Cytotoxin	Cancer
SC209 intermediate-2 (Compound A9) is an intermediate of the ADC cytotoxin SC209 (HY-144880). SC209 intermediate-2 is an ADC Linker .

SC-46944	Renin	Cardiovascular Disease
SC-46944 is an orally active renin inhibitor and can be used for study of hypertension .

Tamrintamab SC-003 mAb; SC-Mab003; SC34.28ss1	ADC Antibody	Cancer
Tamrintamab (SC-003 mAb, SC-Mab003, SC34.28ss1) is an ADC Antibody targeting to dipeptidase 3 (DPEP3 or MBD3). DPEP3 is a glycosyl phosphatidylinositol anchored metallopeptidase that is overexpressed in ovarian tumors. Tamrintamab can specifically bind DPEP3-expressing cells to produce cytotoxicity. Tamrintamab can be used in ovarian cancer research .

SC-53116	5-HT Receptor	Neurological Disease
SC-53116 is a selective 5-HT4 receptor agonist with EC₅₀ at 23 nM .

SC-53116 hydrochloride	5-HT Receptor	Neurological Disease
SC-53116 hydrochloride is a selective 5-HT4 receptor agonist with EC₅₀ at 23 nM .

SC-68376	p38 MAPK	Inflammation/Immunology
SC-68376 is a potent, reversible, ATP-competitive, and selective inhibitor of p38 MAP kinase inhibitor .

SC912	Androgen Receptor Apoptosis	Cancer
SC912 is an AR-V7 inhibitor (IC₅₀ = 0.36 μM). SC912 possesses safety, potency and selectivity. SC912 binds directly to AR-FL and AR-V7 proteins, inhibites nuclear localization and chromatin binding capabilities. SC912 exerts anticancer activity through inhibition of proliferation, induction of cell cycle arrest and apoptosis .

Targeting the bacterial sliding clamp peptide 46	Bacterial	Infection
Targeting the bacterial sliding clamp peptide 46 is a short peptide targeting the bacterial sliding clamp(SC), inhibiting SC-dependent DNA synthesis.

SC75741 10+ Cited Publications	NF-κB Influenza Virus	Infection Cancer
SC75741 is a broad and efficient NF-κB inhibitor with an IC₅₀ of 200 nM for p65 . SC75741 blocks influenza viruses (IV) replication. SC75741 impairs DNA binding of the NF-κB subunit p65, resulting in reduced expression of cytokines, chemokines, and pro-apoptotic factors. SC75741 subsequently inhibits caspase activation and blocks caspase-mediated nuclear export of viral ribonucleoproteins .

Actisomide SC-36602	Apoptosis	Cardiovascular Disease
Actisomide (SC-36602) is an antiarrhythmic agent. Absorption of actisomide in rats and its in vitro uptake in CaCo-2 cells are pH-dependent .

SC428	Androgen Receptor Apoptosis	Cancer
SC428 is an androgen receptor (AR) inhibitor that targets the N-terminal domain. SC428 potently decrease the transactivation of (AR)-V7, (AR)v567es, as well as full-length ( AR ) (AR-FL) and its LBD mutants, substantially. SC428 inhibits androgen-stimulated (AR)-FL nuclear translocation, chromatin binding, and (AR) -regulated gene transcription. SC428 inhibits the proliferation of tumor cells in vitro. SC428 inhibits tumor cell growth by inducing apoptosis in mice transplanted with 22RV1 .

SC239	Drug-Linker Conjugates for ADC	Cancer
SC239 is a cleavable 2-aminophenyl hemiasterlin agent-linker. SC239 can be as the agent-linker for ADC . SC239 is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

4A3-SC8	Liposome	Cancer
4A3-SC8 is a modular degradable dendrimer that enables small RNAs to extend survival in an aggressive liver cancer model .

SC209 intermediate-1	ADC Linker	Cancer
SC209 intermediate-1 (Compound A7a) is an ADC linker. SC209 intermediate-1 can be used for synthesis of ADCs .

5A2-SC8 1 Publications Verification	Liposome	Cancer
5A2-SC8 is an ionizable amino lipid in lipid nanoparticles (LNPs) that shows high delivery potential and low in vivo toxicity, enabling efficient delivery of small RNAs such as siRNA and miRNA into tumor cells. 5A2-SC8 LNPs can confer a unique delivery fate of RNA within the liver, thereby changing the therapeutic outcomes in cancer models .

SC 34301 Enisoprost	Prostaglandin Receptor	Endocrinology
SC 34301 (Enisoprost) is a potent and orally active PGE1 analog. SC 34301 significantly reduces bacterial translocation and improves survival for burned mice .

SC144 5+ Cited Publications	Interleukin Related Apoptosis	Cancer
SC144 is a first-in-class, orally active gp130 (IL6-beta) inhibitor. SC144 binds gp130, induces gp130 phosphorylation (S782) and deglycosylation, abrogates Stat3 phosphorylation and nuclear translocation, and further inhibits the expression of downstream target genes. SC144 shows potent inhibition of gp130 ligand-triggered signaling. SC144 induces apoptosis in human ovarian cancer cells .

SC144 hydrochloride 5+ Cited Publications	Interleukin Related Apoptosis	Cancer
SC144 hydrochloride is a first-in-class, orally active gp130 (IL6-beta) inhibitor. SC144 hydrochloride binds gp130, induces gp130 phosphorylation (S782) and deglycosylation, abrogates Stat3 phosphorylation and nuclear translocation, and further inhibits the expression of downstream target genes. SC144 hydrochloride shows potent inhibition of gp130 ligand-triggered signaling. SC144 hydrochloride induces apoptosis in human ovarian cancer cells .

SC99	STAT JAK Apoptosis	Cardiovascular Disease Cancer
SC99 is an orally active, selective STAT3 inhibitor targeting JAK2-STAT3 pathway. SC99 docks into the ATP-binding pocket of JAK2. SC99 inhibits phosphorylation of JAK2 and STAT3 with no effects on the other kinases associated with STAT3 signaling. SC99 inhibits platelet activation, aggregation and displays potent anti-myeloma, anti-thrombotic activities .

JFD01307SC	Bacterial	Infection Inflammation/Immunology
JFD01307SC is a glutamine synthetase inhibitor and anti-tuberculosis agent. JFD01307SC acts as a mimic of L-Glutamate and thus target enzymes involved in glutamine biosynthesis .

SC-514 5 Publications Verification GK 01140	IKK	Cancer
SC-514 is a selective IKK-2 inhibitor (IC₅₀=11.2 μM), which does not inhibit other IKK isoforms or other serine-threonine and tyrosine kinases.

SC79 Maximum Cited Publications 195 Publications Verification	Akt	Neurological Disease Inflammation/Immunology Cancer
SC79, a unique specific and BBB permeable Akt activator, activates Akt in the cytosol and inhibits Akt membrane translocation. SC79 specifically binds to the PH domain of Akt .

Cat. No.	Product Name	Type

HY-14398GL

Celecoxib (GMP Like) SC 58635 (GMP Like)	Fluorescent Dye
Celecoxib (SC 58635) GMP Like is a GMP-class Celecoxib (HY-14398). Celecoxib, a selective non-steroidal anti-inflammatory drug (NSAID), is a selective COX-2 inhibitor with an IC₅₀ of 40 nM.

Cat. No.	Product Name	Type

HY-145799

5A2-SC8 1 Publications Verification	Drug Delivery
5A2-SC8 is an ionizable amino lipid in lipid nanoparticles (LNPs) that shows high delivery potential and low in vivo toxicity, enabling efficient delivery of small RNAs such as siRNA and miRNA into tumor cells. 5A2-SC8 LNPs can confer a unique delivery fate of RNA within the liver, thereby changing the therapeutic outcomes in cancer models .

HY-14398GL

Celecoxib (GMP Like) SC 58635 (GMP Like)	Biochemical Assay Reagents
Celecoxib (SC 58635) GMP Like is a GMP-class Celecoxib (HY-14398). Celecoxib, a selective non-steroidal anti-inflammatory drug (NSAID), is a selective COX-2 inhibitor with an IC₅₀ of 40 nM.

Cat. No.	Product Name	Target	Research Area

HY-B0361

Aspartame 1 Publications Verification SC-18862	Peptides	Neurological Disease
Aspartame (SC-18862) is a methyl ester of a dipeptide. Aspartame can be used as a synthetic nonnutritive sweetener .

HY-P0323A

GP(33-41) TFA	Arenavirus	Infection
GP(33-41) TFA, a 9-aa-long peptide, is the optimal sequence of the GP1 epitope of lymphocytic choriomeningitis virus. GP(33-41) TFA can upregulate H-2D ^b molecules at the RMA-S (Db Kb) cell surface with a SC₅₀ of 344 nM .

HY-P3326

Targeting the bacterial sliding clamp peptide 46	Bacterial	Infection
Targeting the bacterial sliding clamp peptide 46 is a short peptide targeting the bacterial sliding clamp(SC), inhibiting SC-dependent DNA synthesis.

HY-B0361R

Aspartame (Standard)	Peptides	Neurological Disease
Aspartame (Standard) is the analytical standard of Aspartame. This product is intended for research and analytical applications. Aspartame (SC-18862) is a methyl ester of a dipeptide. Aspartame can be used as a synthetic nonnutritive sweetener .

HY-120794

SC-67655	Peptides	Inflammation/Immunology
SC 67655 is a potent and stable pentapeptide MHC class II haplotype DR4 (DR4 Dw4 or DRB 1"0401) ligand with an IC₅₀ of 50 nM. SC 67655 can be used for the study of autoimmune diseases .

HY-P0323

GP(33-41)	Arenavirus	Infection
GP(33-41), a 9-aa-long peptide, is the optimal sequence of the GP1 epitope of lymphocytic choriomeningitis virus, and can upregulate H-2D ^b molecules at the RMA-S (Db Kb) cell surface with a SC₅₀ of 344 nM .

Cat. No.	Product Name	Target	Research Area

HY-P99506

Tamrintamab SC-003 mAb; SC-Mab003; SC34.28ss1	ADC Antibody	Cancer
Tamrintamab (SC-003 mAb, SC-Mab003, SC34.28ss1) is an ADC Antibody targeting to dipeptidase 3 (DPEP3 or MBD3). DPEP3 is a glycosyl phosphatidylinositol anchored metallopeptidase that is overexpressed in ovarian tumors. Tamrintamab can specifically bind DPEP3-expressing cells to produce cytotoxicity. Tamrintamab can be used in ovarian cancer research .

HY-P99590

Sotatercept ACE-011	TGF-β Receptor	Cardiovascular Disease Inflammation/Immunology Cancer
Sotatercept (ACE-011) is a soluble activin receptor 2A (ACVR2A) type IgG Fc fusion protein. Sotatercept combines activin and growth differentiation factor to try to restore the balance between growth promotion and growth inhibition signal pathways. Sotatercept has potential application in pulmonary arterial hypertension, anemia, bone loss, erythropoiesis, multiple myeloma (MM) osteolytic lesions .

HY-P99886

Pexelizumab h5G1. 1-SC	Complement System Apoptosis	Cardiovascular Disease Neurological Disease
Pexelizumab (h5G1. 1-SC) is a humanized scFv monoclonal antibody directed against the C5 complement component. Pexelizumab inhibits apoptosis and leukocyte infiltration. Pexelizumab can be used for the research of cerebral IR injury and myocardial infarction .

HY-P991041

Anti-SEZ6 Antibody (SC17)	ADC Antibody	Cancer
Anti-SEZ6 Antibody (SC17) is an anti-SEZ6 IgG1 monoclonal antibody. Anti-SEZ6 Antibody (SC17) can be used to synthesize antibody-drug conjugates (ADC) product, ABBV-011 .

Cat. No.	Compare	Product Name	Species	Source

HY-P71280

	SCLY Protein, Human (His) Selenocysteine Lyase; hSCL; SCLY; SCL	Human	E. coli
	SCLY protein plays an important role in selenium metabolism by catalyzing the decomposition of L-selenocysteine to produce L-alanine and elemental selenium. This enzymatic process is critical for regulating intracellular selenium utilization and recycling. SCLY Protein, Human (His) is the recombinant human-derived SCLY protein, expressed by E. coli , with N-6*His labeled tag.

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Cat. No.	Product Name		Classification

HY-148194

SC239		DBCO
SC239 is a cleavable 2-aminophenyl hemiasterlin agent-linker. SC239 can be as the agent-linker for ADC . SC239 is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

Cat. No.	Product Name		Classification

HY-B0361

Aspartame 1 Publications Verification SC-18862		Sweetening Agents
Aspartame (SC-18862) is a methyl ester of a dipeptide. Aspartame can be used as a synthetic nonnutritive sweetener .

HY-148559

4A3-SC8		Cationic Lipids
4A3-SC8 is a modular degradable dendrimer that enables small RNAs to extend survival in an aggressive liver cancer model .

HY-145799

5A2-SC8 1 Publications Verification		Cationic Lipids
5A2-SC8 is an ionizable amino lipid in lipid nanoparticles (LNPs) that shows high delivery potential and low in vivo toxicity, enabling efficient delivery of small RNAs such as siRNA and miRNA into tumor cells. 5A2-SC8 LNPs can confer a unique delivery fate of RNA within the liver, thereby changing the therapeutic outcomes in cancer models .

HY-RS12514

SCLY Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
SCLY Human Pre-designed siRNA Set A contains three designed siRNAs for SCLY gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS12473

SC5D Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
SC5D Human Pre-designed siRNA Set A contains three designed siRNAs for SC5D gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-132587

Fitusiran ALN-AT3SC; SAR439774		siRNAs
Fitusiran (ALN-AT3SC), an small interfering RNA, specifically targets antithrombin (AT) messenger RNA to lower production of AT in the liver. Fitusiran increases thrombin generation and has the potential for the research of the hemophilia .

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SCLY

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

NaturalProducts

Recombinant Proteins

Click Chemistry

Oligonucleotides

Natural
Products