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aminotransferase

" in MedChemExpress (MCE) Product Catalog:

62

Inhibitors & Agonists

3

Biochemical Assay Reagents

16

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12

Natural
Products

13

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1

Isotope-Labeled Compounds

3

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1

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-P3016A

    Endogenous Metabolite Metabolic Disease
    Glutamate oxaloacetate aminotransferase, porcine heart is a transaminase. Glutamate oxaloacetate aminotransferase, porcine heart catalyzes the amino transfer reaction between glutamate and oxaloacetate. Glutamate oxaloacetate aminotransferase, porcine heart can be used in the research of diseases related to disorders of amino acid metabolism .
    Glutamate oxaloacetate aminotransferase, porcine heart
  • HY-P2985

    Endogenous Metabolite Metabolic Disease
    Alanine aminotransferase, Porcine heart is a pyridoxal enzyme that catalyzes the reversible interconversion of L-alanine and 2-oxoglutalate to pyruvate and L-glutamate .
    Alanine aminotransferase, Porcine heart
  • HY-P3016

    EC 2.6.1.1; GOT; AST

    Endogenous Metabolite Others
    Aspartate aminotransferase, Genetically engineered bacteria (EC 2.6.1.1) (AST) is a transaminase enzyme, is often used in biochemical studies. Aspartate aminotransferase catalyzes aspartate and alpha-ketoglutarate converts to oxaloacetate and glutamate. Aspartate aminotransferase can be found in cerebrospinal fluid, exudates, and transudates .
    Aspartate aminotransferase, Genetically engineered bacteria
  • HY-W104477

    Others Metabolic Disease
    3-Fluoro-L-tyrosine is a tyrosine analogue, inhibits transamination by tyrosine aminotransferase (TAT). And 3-FluoroL-tyrosine has been shown to be biologically incorporated into proteins in place of tyrosine. 3-Fluoro-L-tyrosine pretends to be the substrate of rat liver tyrosine aminotransferase, markedly disturbs the Tyr-TAT association .
    3-Fluoro-L-tyrosine
  • HY-141669
    BCAT-IN-2
    2 Publications Verification

    Aminotransferases (Transaminases) Metabolic Disease
    BCAT-IN-2 is a potent, selective and orally active inhibitor of mitochondrial branched-chain aminotransferase (BCATm), with a pIC50 of 7.3. BCAT-IN-2 shows selectivity for BCATm over BCATc (pIC50=6.6). BCAT-IN-2 can be used for the research of obesity and dislipidema .
    BCAT-IN-2
  • HY-P2985A

    Endogenous Metabolite Metabolic Disease
    Alanine aminotransferase, Human liver is an enzyme mainly produced in the liver. Alanine aminotransferase, Human liver is a pyridoxalase that catalyzes the reversible interconversion of L-alanine and 2-oxoglutamic acid into pyruvate and L -Glutamic acid .
    Alanine aminotransferase, Human liver
  • HY-P3016B

    GOT, Human liver; AST, Human liver

    Endogenous Metabolite Metabolic Disease
    Aspartate aminotransferase (GOT), Human liver is an aminotransferase derived from human liver and is commonly used in biochemical research. Aspartate aminotransferase, Human liver catalyzes the conversion of aspartate and alpha-ketoglutarate to oxaloacetate and glutamate .
    Aspartate aminotransferase, Human liver
  • HY-E70327

    Endogenous Metabolite Others
    Aspartate Aminotransferase, Human is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible .
    Aspartate Aminotransferase, Human
  • HY-131921

    Biochemical Assay Reagents Endocrinology
    DL-Glyceraldehyde 3-phosphate diethyl acetal barium is an Aspartate Aminotransferase isozyme inhibitor .
    DL-Glyceraldehyde 3-phosphate diethyl acetal barium
  • HY-W011458

    Amino Acid Derivatives Others
    3,5-Dinitro-L-tyrosine sodium is a tyrosine derivative. 3,5-Dinitro-L-tyrosine sodium as artificial substrate, has zero activity relative to tyrosine as a substrate for tyrosine aminotransferase .
    3,5-Dinitro-L-tyrosine sodium
  • HY-136559

    Nucleoside Antimetabolite/Analog DNA/RNA Synthesis Bacterial Influenza Virus Infection
    6-Azathymine, a 6-nitrogen analog of thymine, is a potent D-3-aminoisobutyrate-pyruvate aminotransferase inhibitor. 6-Azathymine inhibits the biosynthesis of DNA, and has antibacterial and antiviral activities .
    6-Azathymine
  • HY-W193545A
    ERG240
    3 Publications Verification

    Others Inflammation/Immunology Cancer
    ERG240 is an oral active branched-chain amino acid aminotransferase 1 (BCAT1) inhibitor. ERG240 can be used for the research of cancer, rheumatoid arthritis, and bone disease .
    ERG240
  • HY-158309

    Aminotransferases (Transaminases) Cancer
    hOAT-IN-1 (compound 5) is a mechanical inhibitor of human ornithine aminotransferase (hOAT). hOAT-IN-1 as a time-dependent inhibitor can form tightly bound PLP inhibitor adduct with hOAT. hOAT-IN-1 can result IN tight occupation of the active site of hOAT. hOAT-IN-1 can be used in the study of lung cell carcinoma .
    hOAT-IN-1
  • HY-113820

    PPAR Metabolic Disease
    AZD4619 is an orally active, selective peroxisome proliferator-activated receptor α (PPARα) agonist. AZD4619 increases alanine aminotransferase 1 (ALT1) protein expression in a dose-dependent manner in human, but not in rat primary hepatocytes. AZD4619 is a lipid-lowering drug .
    AZD4619
  • HY-124825

    Others Cancer
    iGOT1-01 is a potent aspartate aminotransferase 1 (glutamate oxaloacetate transaminase 1; GOT1) inhibitor. iGOT1-01 has IC50s of 85 μM and 11.3 μM in MDH coupled GOT1 enzymatic assay and GOT1/GLOX/HRP assay, respectively. iGOT1-01 has anti-cancer activity .
    iGOT1-01
  • HY-N4033

    7α-Hydroxyroyleanone

    Bacterial Infection
    Horminone is an abietan diterpene quinone that can be isolated from Labiatae family. Horminone increases of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) serum levels in vivo. Horminone inhibits the growth of Trypanosoma cruzi and shows antibacterial activity .
    Horminone
  • HY-119136

    Others Others
    BFF-122 is a compound that selectively inhibits mammalian kynurenine aminotransferase II.
    BFF-122
  • HY-N15001

    GABA Receptor Neurological Disease
    Gabaculine is found in the strain of Streptomyces toyocaensis. Gabaculine inhibits GABA aminotransferase .
    Gabaculine
  • HY-165496

    Histone Methyltransferase Others
    KAT-IN-2 (7) is a potent and selective kynurenine aminotransferase II (KATII) inhibitor .
    KAT-IN-2
  • HY-163863

    Biochemical Assay Reagents Others
    Fast Red RC salt, 97% is used in plant science to detect aminotransferase activity and as a marker for phosphatase activity in diagnostic procedures.
    Fast Red RC salt, 97%
  • HY-P2891A

    PoxB, Aerococcus viridans

    Endogenous Metabolite Others
    Pyruvate oxidase, Aerococcus viridans (PoxB) is a thiamine pyrophosphate-dependent oxidase that catalyzes the oxidative decarboxylation of pyruvate to produce acetyl phosphate, carbon dioxide, and water. Pyruvate oxidase, Aerococcus viridans is an important enzyme in bacterial metabolism and can enhance ATP production. Additionally, Pyruvate oxidase, Aerococcus viridans can be used for the determination of aspartate aminotransferase and alanine aminotransferase activities .
    Pyruvate oxidase, Aerococcus viridans
  • HY-156962

    Aminotransferases (Transaminases) Others
    BFF-816 is an orally active kynurenine aminotransferase II (KAT II) inhibitor. BFF-816 can be used in the research of the neurobiology of KYNA .
    BFF-816
  • HY-15600B

    Aryl Hydrocarbon Receptor Neurological Disease
    UPF-648 sodium salt is an effective inhibitor of kynurenine 3-monooxygenase (KMO), achieving approximately 81% inhibition at a concentration of 1uM, with no inhibitory effect on kynurenine aminotransferase (KAT).
    UPF-648 sodium salt
  • HY-N5092

    Reactive Oxygen Species (ROS) Cytochrome P450 Metabolic Disease
    7-Methylcoumarin is a coumarin derivative with potent hepatoprotective and antioxidant properties. 7-Methylcoumarin is a mechanism-based inhibitor for CYP2A6. 7-Methylcoumarin significantly decreases alanine aminotransferase (ALT), aspartate aminotransferase (AST), and serum bilirubin (TB) in rats with CCl4-induced liver damage, whilst restoring total protein (TP) and albumin (TA) levels in serum as well as preventing oxidative stress. 7-Methylcoumarin can decline mitotic activity of A. sativum promeristem .
    7-Methylcoumarin
  • HY-113013

    β-Hydroxypyruvic acid; 3-Hydroxypyruvic acid

    Endogenous Metabolite Metabolic Disease
    Hydroxypyruvic acid (β-Hydroxypyruvic acid) is an intermediate in the metabolism of glycine, serine and threonine. Hydroxypyruvic acid is a substrate for serine-pyruvate aminotransferase and glyoxylate reductase/hydroxypyruvate reductase. Hydroxypyruvic acid is involved in the metabolic disorder which is the dimethylglycine dehydrogenase deficiency pathway.
    Hydroxypyruvic acid
  • HY-147982

    GABA Receptor Neurological Disease
    GABA-AT-IN-1 (Compound 6) is a γ-aminobutyric acid aminotransferase (GABA-AT) inhibitor and significantly elevates the mouse brain GABA level. GABA-AT-IN-1 has the ability to cross the BBB and can be used as an anticonvulsant .
    GABA-AT-IN-1
  • HY-154021A

    5-FMOrn dihydrochloride

    OAT Metabolic Disease
    5-Fluoromethylornithine (5-FMOrn) dihydrochloride is a specific irreversible inhibitor of L-ornithine:2-oxoacid aminotransferase (OAT). 5-Fluoromethylornithine dihydrochloride can be used in the study of gyrate atrophy of choroid and retina .
    5-Fluoromethylornithine dihydrochloride
  • HY-154629
    Sesame Oil
    1 Publications Verification

    Biochemical Assay Reagents NF-κB Aminotransferases (Transaminases) Interleukin Related NO Synthase Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
    Sesame Oil is a vegetable oil. Sesame Oil can be extracted from the seeds of Sesamum indicum L. Sesame Oil decreases NF-κB, aspartate aminotransferase, alanine aminotransferase, IL-1β, IL-4 and nitric oxide. Sesame Oil has antitumor activity against malignant melanoma. Sesame Oil has protective effects against liver damage caused by various agents such as Cisplatin (HY-17394) and Acetaminophen (HY-66005). Sesame Oil shows antinociceptive and anti-inflammatory activities .
    Sesame Oil
  • HY-176192

    Toll-like Receptor (TLR) TNF Receptor NF-κB p38 MAPK ERK IKK Inflammation/Immunology
    SMU-14a is a TLR3 inhibitor (IC50: 0.18 µM). SMU-14a inhibits IL-6 secretion in mouse peritoneal macrophages and downregulates TNF-α in human peripheral blood monocytes. SMU-14a exerts anti-inflammatory effects by reducing the phosphorylation of p65, ERK, and TBK1 through NF-κB, MAPK, and IRF3 signaling pathways, and decreasing serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels. SMU-14a can be used in the study of acute hepatitis .
    SMU-14a
  • HY-P1887

    HSP Infection
    p5 Ligand for Dnak and DnaJ is a nonapeptide, which corresponds to the main binding site for the 23-residue part of the presequence of mitochondrial aspartate aminotransferase. p5 Ligand for Dnak and DnaJ is a high-affinity ligand for DnaK and DnaJ .
    p5 Ligand for Dnak and DnaJ
  • HY-113013A

    β-Hydroxypyruvic acid lithium hydrate; 3-Hydroxypyruvic acid lithium hydrate

    Endogenous Metabolite Metabolic Disease
    Hydroxypyruvic acid lithium hydrate (β-Hydroxypyruvic acid lithium hydrate) is an intermediate in the metabolism of glycine, serine and threonine. Hydroxypyruvic acid lithium hydrate is a substrate for serine-pyruvate aminotransferase and glyoxylate reductase/hydroxypyruvate reductase. Hydroxypyruvic acid lithium hydrate is involved in the metabolic disorder which is the dimethylglycine dehydrogenase deficiency pathway.
    Hydroxypyruvic acid lithium hydrate
  • HY-N5092R

    Reference Standards Reactive Oxygen Species (ROS) Cytochrome P450 Metabolic Disease
    7-Methylcoumarin (Standard) is the analytical standard of 7-Methylcoumarin. This product is intended for research and analytical applications. 7-Methylcoumarin is a coumarin derivative with potent hepatoprotective and antioxidant properties. 7-Methylcoumarin is a mechanism-based inhibitor for CYP2A6. 7-Methylcoumarin significantly decreases alanine aminotransferase (ALT), aspartate aminotransferase (AST), and serum bilirubin (TB) in rats with CCl4-induced liver damage, whilst restoring total protein (TP) and albumin (TA) levels in serum as well as preventing oxidative stress. 7-Methylcoumarin can decline mitotic activity of A. sativum promeristem .
    7-Methylcoumarin (Standard)
  • HY-E70061

    Others Others
    alpha-1,3-N-Acetylgalactosaminyltransferase (BgtA) is an acetylgalactose aminotransferase, which can be isolated from Helicobacter mustelae, and can specifically recognize Fucα1,2-Gal epitopes .
    alpha-1,3-N-Acetylgalactosaminyltransferase (BgtA)
  • HY-117247

    DNA/RNA Synthesis Infection
    5,6,7,8-Tetrahydro-8-deazahomofolic acid is a potential thymidylate synthase (TS) inhibitor with inhibitory activity against other folate-related enzymes. 5,6,7,8-Tetrahydro-8-deazahomofolic acid showed mild growth inhibition against enterococci, lactic acid bacteria, and L1210 cells in culture. 5,6,7,8-Tetrahydro-8-deazahomofolic acid also showed weak inhibition against thymidylate synthase, dihydrofolate reductase, glycyl-ribonucleoside aminotransferase, and aminoimidazole-carboxyacyl-ribonucleoside aminotransferase. 5,6,7,8-Tetrahydro-8-deazahomofolic acid showed low substrate activity for thymidylate synthase .
    5,6,7,8-Tetrahydro-8-deazahomofolic acid
  • HY-115685

    GABA Receptor Neurological Disease
    3-Methyl-GABA is a potent GABA aminotransferase activator. 3-Methyl-GABA can fit the binding pocket of GABAA receptor (GABAaR). 3-Methyl-GABA can activate L-glutamic acid decarboxylase (GAD). 3-Methyl-GABA has anticonvulsant activity .
    3-Methyl-GABA
  • HY-N6237

    Aminotransferases (Transaminases) Apoptosis Cancer
    Aspulvinone O is a selective inhibitor of glutamate oxaloacetate aminotransferase GOT1. Aspulvinone O inhibits glutamine metabolism and reduces NADPH production, thereby inducing oxidative stress and apoptosis in pancreatic ductal adenocarcinoma (PDAC) cells. Aspulvinone O inhibits PDAC cell proliferation in vitro and tumor growth in xenograft models .
    Aspulvinone O
  • HY-116451
    PF-04859989 hydrochloride
    1 Publications Verification

    Aminotransferases (Transaminases) Neurological Disease
    PF-04859989 hydrochloride is a brain-penetrant, irreversible kynurenine aminotransferase (KAT) II inhibitor with IC50s of 23 and 263 nM for hKAT II and rKAT II. PF-04859989 hydrochloride is selective for KAT II over human KAT I, KAT III, and KAT IV (IC50s of 22, 11, and >50 μM, respectively) .
    PF-04859989 hydrochloride
  • HY-129476

    Parasite Endogenous Metabolite Infection Cancer
    L-Canaline is a nonprotein amino acid stored in many leguminous plants. L-Canaline is a cytotoxic metabolite catalyzed by L-canavanine and its arginase. L-Canaline is a potent and irreversible inhibitor of ornithine aminotransferase. L-Canaline inhibits the growth of the malaria parasite Plasmodium falciparum with an IC50 of 297 nM. L-Canaline has anticancer and antiproliferative effects .
    L-Canaline
  • HY-W422400

    Biochemical Assay Reagents Others Cancer
    Fluoroglutamine (2S,4R) is a fluorinated derivative of glutamine. As a substrate for various aminotransferases, Fluoroglutamine (2S,4R) can be used as a tracer for positron emission tomography (PET) imaging. Fluoroglutamine (2S,4R) is applied in the research fields of tumor metabolism and imaging .
    Fluoroglutamine (2S,4R)
  • HY-116044
    BCATc Inhibitor 2
    4 Publications Verification

    Aminotransferases (Transaminases) Neurological Disease
    BCATc Inhibitor 2 is a selective branched-chain aminotransferase (BCAT) inhibitor for research of neurodegenerative diseases. The IC50s of 0.2 μM, 0.8 μM and 3.0 μM for rat cytosolic isoenzyme rBCATc, human cytosolic isoenzyme hBCATc and rat mitochondrial isoenzyme rBCATm, respectively. BCATc, also called BCAT1, is in the cytoplasm .
    BCATc Inhibitor 2
  • HY-113967

    Aminotransferases (Transaminases) Neurological Disease
    PF-04859989 is a brain-penetrant, irreversible kynurenine aminotransferase (KAT) II inhibitor with IC50s of 23 and 263 nM for hKAT II and rKAT II. PF-04859989 is selective for KAT II over human KAT I, KAT III, and KAT IV (IC50s of 22, 11, and >50 μM, respectively) .
    PF-04859989
  • HY-147064A

    Endogenous Metabolite Others
    DL-4-Hydroxy-2-ketoglutarate serves as a substrate for the enzymes GOT (glutamic oxalacetic aminotransferase) and 2-keto-4-hydroxyglutarate aldolase, facilitating the reversible breakdown of 2-keto-4-hydroxyglutarate into pyruvate and glyoxylate; it has also found applications in mass spectrometry for the swift analysis of negatively charged, water-soluble cellular metabolites.
    DL-4-Hydroxy-2-ketoglutarate
  • HY-109089S

    15(S)-HEPE-d5 ethyl ester; 15(S)-Hydoxy EPA-d5 ethyl ester; 15(S)-Hydoxy eicosapetaeoic acid-d5 ethyl ester

    Isotope-Labeled Compounds Others Others
    Epeleuton-d5 (15(S)-HEPE-d5 ethyl ester) is deuterium labeled Epeleuton. Epeleuton is a second-generation synthetic N-3 fatty acid derivative with activity in patients with non-alcoholic fatty liver disease, although it did not reach the primary endpoints of alanine aminotransferase and liver stiffness, but it can significantly reduce triglycerides, glycated hemoglobin, plasma glucose and inflammatory markers .
    Epeleuton-d5
  • HY-P2075

    Renin Endocrinology
    EMD 55068 is a renin antagonist. EMD 55068 inhibits the uptake of taurocholate .
    EMD 55068
  • HY-P2336A
    CCZ01048 TFA
    2 Publications Verification

    Melanocortin Receptor Cancer
    CCZ01048 TFA, a α-MSH analogue, exhibits high binding affinity to melanocortin 1 receptor (MC1R) with a Ki of 0.31 nM. CCZ01048 TFA shows rapid internalization into B16F10 melanoma cells and high in vivo stability. CCZ01048 TFA is a promising candidate for PET imaging of malignant melanoma .
    CCZ01048 TFA
  • HY-P10472

    GnRH Receptor Endocrinology
    Azaline B is an antagonist for gonadotropin-releasing hormone (GnRH) with IC50 of 1.37 nM, Azaline B can be used in research of sex hormone-related pathological states, ovulation induction and male contraception .
    Azaline B
  • HY-N15587

    Gostatine

    Aminotransferases (Transaminases) Metabolic Disease
    Gostatin is an inhibitor of aspartate aminotransferase (GOT). Gostatin is found in Streptomyces sumanensis nov. sp. NK-23. Gostatin has a strong inhibitory effect on pig heart GOT, a weak inhibitory effect on wheat germ GOT and GPT, and no significant effect on glutamate dehydrogenase and glutamine synthetase. The inhibitory mechanism of gostatin is similar to substrate competitive inhibition, and aspartate has a protective effect on its inhibitory effect. Gostatin can be used to study the catalytic mechanism of GOT and its role in nitrogen metabolism .
    Gostatin
  • HY-B1051
    Flumethasone
    1 Publications Verification

    Flumetasone

    Glucocorticoid Receptor TNF Receptor Interleukin Related Keap1-Nrf2 Inflammation/Immunology Endocrinology Cancer
    Flumethasone (Flumetasone) is an orally active, high selective and potent glucocorticoid receptor (GR) agonist. Flumethasone activates GR to inhibit nuclear factor kappa B (NF-κB)-mediated pro-inflammatory cytokine production (TNF-α, IL-1β) and promotes anti-inflammatory gene expression (IL-10), while also regulating metabolic enzyme activity (tyrosine aminotransferase induction). Flumethasone is promising for research of inflammatory diseases, cancer, and endocrine regulation .
    Flumethasone
  • HY-P4757

    Parasite Others
    N1-Glutathionyl-spermidine disulfide is a substrate of trypanothione reductase .
    N1-Glutathionyl-spermidine disulfide
  • HY-19904A

    (+/-)-LY2409021

    Endogenous Metabolite Metabolic Disease
    (+/-)-Adomeglivant ((+/-)-LY2409021) is a potent and selective glucagon receptor antagonist with hypoglycemic activity. (+/-)-Adomeglivant is effective in lowering blood sugar levels in both healthy people and people with type 2 diabetes. (+/-)-Adomeglivant is well tolerated by glucagon signaling blockade in patients with type 2 diabetes and significantly reduces fasting and postprandial blood glucose with a concomitant reversible elevation of aminotransferases. Glucagon signaling inhibition by (+/-)-Adomeglivant is a promising potential inhibitory approach for patients with type 2 diabetes and warrants further evaluation of its benefits and risks in longer clinical trials .
    (+/-)-Adomeglivant

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