Search Result

Pathways Recommended:	Anti-infection

Results for "

anti HIV-1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	HIV (93) HIV Integrase (6) HIV Protease (13) 11β-HSD (1) AMPK (1) Antibiotic (6) Apoptosis (10) Autophagy (7) Bacterial (12) Bcl-2 Family (1) Calcium Channel (1) CCR (7) CDK (1) Complement System (2) CXCR (5) Dengue Virus (2) DNA/RNA Synthesis (1) FAK (2) Flavivirus (2) Fungal (1) HBV (1) HSV (3) IKK (2) Influenza Virus (2) Isotope-Labeled Compounds (1) JAK (2) Microtubule/Tubulin (1) Mitophagy (2) MMP (3) Parasite (6) Phosphatase (1) PKC (1) Reactive Oxygen Species (3) Reverse Transcriptase (7) SARS-CoV (8) Src (1) STAT (1) ULK (1) Virus Protease (1)
By Research Areas:	Cancer (26) Cardiovascular Disease (2) Endocrinology (2) Infection (100) Inflammation/Immunology (18) Metabolic Disease (2) Neurological Disease (2)
Click Chemistry:	Alkynes (1)

111

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Click Chemistry

Targets Recommended: HIV HIV Integrase HIV Protease

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-109056

Elsulfavirine R-1206	HIV	Infection
Elsulfavirine is a reverse transcriptase inhibitors for *HIV-1* infection and is a new anti-HIV agent .

HY-104012

Islatravir 2 Publications Verification MK-8591	HIV Reverse Transcriptase	Infection
Islatravir (MK-8591) is a potent anti-HIV-1 agent, acting as a nucleoside reverse transcriptase inhibitor, with EC₅₀s of 0.068 nM, 3.1 nM and 0.15 nM for HIV-1 (WT), HIV-1 (M184V), HIV-1 (MDR), respectively. Islatravir is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-N1111

Uncaric acid 6β,19α-Dihydroxyursolic acid	HIV	Infection
Uncaric acid (6β,19α-Dihydroxyursolic acid) (compound 6) is a triterpene that can be found in Eriobotrya japonica. Uncaric acid shows anti HIV-1, HRV 1B, SNV activity .

HY-161986

HIV-1 inhibitor-74	HIV	Infection
HIV-1 inhibitor-74 (compound 10c) is a potent *HIV-1* inhibitor with an EC₅₀ value of 0.0047 µM for HIV-1 IIIB. HIV-1 inhibitor-74 shows cytotoxicity. HIV-1 inhibitor-74 inhibits WT HIV-1 RT activity with an IC₅₀ value of 0.134 µM. HIV-1 inhibitor-74 shows broad-spectrum anti HIV-1 activity .

HY-152539

HIV-1 inhibitor-54	HIV	Infection
HIV-1 inhibitor-54 is a potent *HIV-1* inhibitor. HIV-1 inhibitor-54 has anti-HIV activity in MT-4 cells against WT HIV-1 (strain IIIB) with an EC₅₀ value of 0.032 μM. HIV-1 inhibitor-54 can be used for the research of virus infection .

HY-168189

HIV-1 inhibitor-76	HIV	Infection
HIV-1 inhibitor-76 (compound 9t-2) is a non-nucleoside reverse transcriptase inhibitor of *HIV-1. HIV-1* inhibitor-76 can be used in anti-HIV research .

HY-147723

HIV-1 inhibitor-39	HIV	Infection
HIV-1 inhibitor-39 (compound 3c) is a potent *HIV-1* inhibitor with an EC₅₀ of >112.88 µM. HIV-1 inhibitor-39 shows anti-RT (HIV-1 reverse transcriptase) activities with an IC₅₀ of 15.75 µM. HIV-1 inhibitor-39 shows cytotoxicity for MT-4 cells with an CC₅₀ of 112.9 µM .

HY-P1586

HIV-1 Rev (34-50) HIV-1 rev Protein (34-50)	HIV	Infection
HIV-1 Rev (34-50) is a 17-aa peptide derived from the Rev-responsive element (RRE)-binding domains of Rev in HIV-1, with anti-HIV-1 activity.

HY-126900

HI-253	HIV Reverse Transcriptase	Others
HI-253 is a non-nucleoside inhibitor of HIV-1 reverse transcriptase that has demonstrated greater activity than multiple anti-HIV compounds against both resistant and sensitive HIV-1 strains.

HY-146353

HIV-1 inhibitor-29	HIV	Infection Inflammation/Immunology
HIV-1 inhibitor-29 (compound 14d2) is a potent *HIV-1* inhibitor with an EC₅₀ of 2.18 μM for HIV-1 IIIB. HIV-1 inhibitor-29 has high anti-resistance profile toward F227L/V106A strain (EC₅₀ = 0.974 μM), and exhibits low cytotoxicity in MT-4 cells (CC₅₀ = 211 μM). HIV-1 inhibitor-29 can be used for researching AIDS .

HY-P10517

Sifuvirtide SFT	HIV	Infection
Sifuvirtide (SFT) is a potent *HIV* fusion inhibitor. Sifuvirtide inhibits *HIV-1* mediated cell fusion in a dose-dependent manner and is highly potent against infection by primary and laboratory-adapted *HIV-1* isolates of multiple genotypes. Sifuvirtide can be used in the research of anti-HIV drugs .

HY-P10517A

Sifuvirtide acetate SFT acetate	HIV	Infection
Sifuvirtide (SFT) acetate is a potent *HIV* fusion inhibitor. Sifuvirtide acetate inhibits *HIV-1* mediated cell fusion in a dose-dependent manner and is highly potent against infection by primary and laboratory-adapted *HIV-1* isolates of multiple genotypes. Sifuvirtide acetate can be used in the research of anti-HIV drugs .

HY-114731

Adenallene	HIV	Infection
Adenallene, a nucleoside analogue, is an anti-HIV compound. Adenallene inhibits replication and cytopathic effect of HIV-1 and HIV-2 .

HY-W325699

HIV-1 inhibitor-48	HIV Reverse Transcriptase	Infection
HIV-1 inhibitor-48 (compound 13o) is a novel non-nucleoside reverse transcriptase inhibitor (NNRTI) and exhibits anti-HIV-1 activity .

HY-N2010

Methyl gallate 1 Publications Verification Gallincin; NSC 363001	Bacterial HIV Reactive Oxygen Species	Infection Cardiovascular Disease Cancer
Methyl gallate is a plant phenolic with antioxidant, anticancer, and anti-inflammatory activities. Methyl gallate also shows bacterial inhibition activity. Methyl gallate also has anti-HIV-1 and *HIV-1* enzyme inhibitory activities.

HY-116469

ZP7	HIV	Infection
ZP7 (compound 7c) is a potent anti-HIV-1 agent with an EC₅₀ of 36.4nM. ZP7 can be utilized in HIV-1 research .

HY-119120

JTK-101	HIV CDK	Infection Inflammation/Immunology
JTK-101 is a selective *HIV* inhibitor. JTK-101 selectively reduces *HIV-1* mRNA synthesis by inhibiting Tat cofactors, including CDK9 and cyclin T1, thereby suppressing the transcriptional activity of HIV-1. JTK-101 may be used in the field of anti-HIV virus research .

HY-17605A

Bictegravir sodium 10+ Cited Publications GS-9883 sodium	HIV Integrase HIV	Infection
Bictegravir sodium is a potent inhibitor of HIV-1 integrase, with an IC₅₀ of 7.5 nM. Bictegravir sodium exhibits potent and selective anti-HIV activity and low cytotoxicity .

HY-N1372A

Fangchinoline 5+ Cited Publications	HIV FAK Apoptosis Autophagy	Infection Cancer
Fangchinoline is isolated from Stephania tetrandra with extensive biological activities, such as enhancing immunity, anti-inflammatory sterilization and anti-atherosclerosis. Fangchinoline, a novel *HIV-1* inhibitor, inhibits HIV-1 replication by impairing gp160 proteolytic processing . Fangchinoline targets Focal adhesion kinase (FAK) and suppresses FAK-mediated signaling pathway in tumor cells which highly expressed FAK . Fangchinoline induces apoptosis and adaptive autophagy in bladder cancer .

HY-161924

HIV-1 inhibitor-73	HIV	Infection
HIV-1 inhibitor-73 (compound 13c) is a potent anti-HIV-1 agent, against the whole tested viral panel with EC50 ranging from 4.68 to 229 nM .

HY-111964A

Lenacapavir sodium GS-6207 sodium	HIV	Infection
Lenacapavir (GS-6207) sodium is a *HIV-1* capsid inhibitor. Lenacapavir sodium shows anti-HIV activity with an EC₅₀ of 100 pM in MT-4 cells. Lenacapavir sodium displays a mean EC₅₀ of 50 pM (20-160 pM) against 23 HIV-1 clinical isolates from different subtypes in peripheral blood mononuclear cells (PBMCs) .

HY-116528

GCA-186	HIV	Infection
GCA-186 is a potent *anti-HIV-1* agent. GCA-186 is highly active against both wild type and mutated HIV-1 strains with EC₅₀s of 1, 180, 1, and 40 nM for III_B, III_B-R(Y181C), NL4-3 and NL4-3_K103N of HIV-1 strains, respectively .

HY-125028

Hck-IN-1 1 Publications Verification	Src HIV	Infection
Hck-IN-1 (compound B9), a diphenylpyrazolo compound, is a selective Nef-dependent Hck inhibitor with IC₅₀s of 2.8 μM, >20 μM for Nef:Hck complex and Hck, respectively. Hck-IN-1 is a direct and wide HIV-1 Nef antagonists with an IC₅₀ of 100-300 nM for wild-type HIV-1 replication. Hck-IN-1 binds pocket residue Asn126 and has anti-retroviral activity .

HY-N1372AR

Fangchinoline (Standard)	HIV FAK Apoptosis Autophagy	Infection Cancer
Fangchinoline (Standard) is the analytical standard of Fangchinoline. This product is intended for research and analytical applications. Fangchinoline is isolated from Stephania tetrandra with extensive biological activities, such as enhancing immunity, anti-inflammatory sterilization and anti-atherosclerosis. Fangchinoline, a novel HIV-1 inhibitor, inhibits HIV-1 replication by impairing gp160 proteolytic processing . Fangchinoline targets Focal adhesion kinase (FAK) and suppresses FAK-mediated signaling pathway in tumor cells which highly expressed FAK . Fangchinoline induces apoptosis and adaptive autophagy in bladder cancer .

HY-N2010R

Methyl gallate (Standard)	Bacterial HIV Reactive Oxygen Species	Infection Cardiovascular Disease Cancer
Methyl gallate (Standard) is the analytical standard of Methyl gallate. This product is intended for research and analytical applications. Methyl gallate is a plant phenolic with antioxidant, anticancer, and anti-inflammatory activities. Methyl gallate also shows bacterial inhibition activity. Methyl gallate also has anti-HIV-1 and HIV-1 enzyme inhibitory activities.

HY-14882A

Cenicriviroc Mesylate 5+ Cited Publications TAK-652 Mesylate; TBR-652 Mesylate	CCR HIV	Infection Inflammation/Immunology Endocrinology
Cenicriviroc Mesylate (TAK-652 Mesylate) is a dual CCR2/CCR5 antagonist, also inhibits both HIV-1 and HIV-2, and displays potent anti-inflammatory and antiinfective activity.

HY-100870

Obefazimod ABX464	HIV	Infection
Obefazimod (ABX464) is a potent *anti-HIV* agent. Obefazimod inhibits *HIV-1* replication in stimulated peripheral blood mononuclear cells (PBMCs) with an IC₅₀ ranging between 0.1 μM and 0.5 μM.

HY-18300

Filgotinib 15+ Cited Publications GLPG0634	JAK HIV	Cancer
Filgotinib (GLPG0634) is a selective, orally available JAK1 inhibitor with anti-inflammatory and antiviral activities. Filgotinib can effectively inhibit the activities of JAK1, JAK2, JAK3 and TYK2 with IC₅₀ values of 10 nM, 28 nM, 810 nM and 116 nM, respectively. Filgotinib also inhibits *HIV-1* driven gene transcription and reduces proliferation of *HIV-1* infected cells. Filgotinib can be used in the study of rheumatoid arthritis and inflammatory bowel disease .

HY-18300A

Filgotinib maleate 15+ Cited Publications GLPG0634 maleate	JAK HIV	Inflammation/Immunology
Filgotinib maleate (GLPG0634 maleate) is a selective, orally available JAK1 inhibitor with anti-inflammatory and antiviral activities. Filgotinib maleate can effectively inhibit the activities of JAK1, JAK2, JAK3 and TYK2 with IC₅₀ values of 10 nM, 28 nM, 810 nM and 116 nM, respectively. Filgotinib maleate also inhibits *HIV-1* driven gene transcription and reduces proliferation of *HIV-1* infected cells. Filgotinib maleate can be used in the study of rheumatoid arthritis and inflammatory bowel disease .

HY-A0162R

Quinupristin (Standard)	Antibiotic Bacterial	Infection
Bictegravir (sodium) (Standard) is the analytical standard of Bictegravir (sodium). This product is intended for research and analytical applications. Bictegravir sodium is a potent inhibitor of HIV-1 integrase, with an IC50 of 7.5 nM. Bictegravir sodium exhibits potent and selective anti-HIV activity and low cytotoxicity .

HY-17605AR

Bictegravir (sodium) (Standard)	HIV Integrase HIV	Infection
Bictegravir (sodium) (Standard) is the analytical standard of Bictegravir (sodium). This product is intended for research and analytical applications. Bictegravir sodium is a potent inhibitor of HIV-1 integrase, with an IC50 of 7.5 nM. Bictegravir sodium exhibits potent and selective anti-HIV activity and low cytotoxicity .

HY-14882

Cenicriviroc 5+ Cited Publications TAK-652; TBR-652	CCR HIV	Infection Endocrinology
Cenicriviroc (TAK-652) is an orally active, dual CCR2/CCR5 antagonist, also inhibits both HIV-1 and HIV-2, and displays potent anti-inflammatory and antiinfective activity .

HY-118747

Scirpusin A	HIV	Infection
Scirpusin A is a naturally occurring compound extracted from the legume plant Caragana rosea Turcz, exhibiting anti-HIV activity. Scirpusin A demonstrates significant inhibitory effects against *HIV-1* (EC₅₀=7 μg/mL). Scirpusin A is utilized in research towards the development of anti-HIV therapeutics .

HY-111964

Lenacapavir 10+ Cited Publications GS-6207	HIV	Infection
Lenacapavir (GS-6207) is a HIV-1 capsid inhibitor. Lenacapavir shows anti-HIV activity with an EC₅₀ of 100 pM in MT-4 cells. Lenacapavir displays a mean EC₅₀ of 50 pM (20-160 pM) against 23 HIV-1 clinical isolates from different subtypes in peripheral blood mononuclear cells (PBMCs) . Lenacapavir is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-19149

Ro24-7429	HIV Apoptosis	Infection Inflammation/Immunology Cancer
Ro24-7429 is a potent and orally active HIV-1 transactivator protein Tat antagonist. Ro24-7429 is also a runt-related transcription factor 1 (RUNX1) inhibitor. Ro24-7429 has anti-HIV, antifibrotic and anti-inflammatory effects .

HY-122058

KRH-3955	HIV	Infection
KRH-3955 is a CXCR4 antagonist with good bioavailability and potent anti-HIV-1 activity. KRH-3955 can effectively inhibit the replication of X4 HIV-1, including clinical isolates from different donors. KRH-3955 also shows activity against recombinant X4 HIV-1 containing reverse transcriptase, protease and tyrosinase resistance mutations. KRH-3955 can inhibit the binding of SDF-1alpha to CXCR4 and calcium ion signaling through this receptor. KRH-3955 inhibits the binding of an antibody against CXCR4 to CXCR4, showing a potent antagonistic effect on CXCR4. KRH-3955 shows an oral bioavailability of 25.6% in rats and can inhibit the replication of X4 HIV-1 in vivo .

HY-P4810

Polyphemusin II-Derived Peptide T140	CXCR	Infection
Polyphemusin II-Derived Peptide (T140), a CXCR4 inhibitor, shows high inhibitory activity against HIV-1 entry and the inhibitory effect on the binding of an anti-CXCR4 monoclonal antibody (12G5) to CXCR4 .

HY-161945

IN-RNA-IN-2	HIV HIV Integrase	Infection
IN-RNA-IN-2 (compound 1a) is an inhibitor (IC₅₀=70 nM) of the interaction between HIV-1 integrase and the viral RNA genome. IN-RNA-IN-2 exerts its anti-HIV activity by inhibiting the viral replication process .

HY-N11097

FK-3000	Apoptosis HSV HIV	Infection Cancer
FK-3000 is a potent anti-tumor agent that inhibits the growth of carcinoma cells through apoptosis and induction cell cycle arrest. FK-3000 also exhibit antiviral effects against HSV-1 and *HIV-1* .

HY-106395A

(Rac)-Telinavir (Rac)-SC-52151	HIV Protease	Infection
(Rac)-Telinavir ((Rac)-SC-52151) is a potent, selective, tight-binding human immunodeficiency virus (HIV) protease inhibitor that exhibits significant anti-HIV activity. (Rac)-Telinavir has a mean 50% effective concentration of 26 ng/ml (43 nM) against various strains of HIV, including HIV-1, HIV-2, and simian immunodeficiency virus. (Rac)-Telinavir, in combination with nucleoside reverse transcriptase inhibitors, demonstrates synergistic effects on inhibiting HIV-1 replication without additive toxicity. (Rac)-Telinavir is highly protein bound in human plasma and exhibits low partitioning into erythrocytes.

HY-19827

Aeroplysinin 1 (+)-Aeroplysinin-1	Bacterial HIV Apoptosis	Infection Cancer
Aeroplysinin 1 ((+)-Aeroplysinin-1), a secondary metabolite isolated from marine sponges, shows potent antibiotic effects on Gram-positive bacteria and exerts antiviral activity against *HIV-1* (IC₅₀=14.6 μM). Aeroplysinin 1 has anti-inflammatory, anti-angiogenic and anti-tumor activities. Aeroplysinin 1 induces apoptosis in endothelial cells .

HY-130000

Pirmitegravir STP0404	HIV Integrase HIV	Infection
Pirmitegravir is a potent and first-in-class inhibitor of allosteric integrase (ALLINI) that targets LEDGF/p75 binding site. Pirmitegravir displays picomolar IC₅₀ in human PBMCs with a >24,000 therapeutic index against HIV-1. Pirmitegravir harbors outstanding anti-virus and safety properties .

HY-163617

c-PB2(OH)2	HIV	Infection
c-PB2(OH)2 is a 4-carboxyphenyl / 4-hydroxyphenyl meso-substituted porphyrin compound. c-PB2(OH)2 shows anti *HIV-1* activity under non-photodynamic and photodynamic conditions .

HY-P99697

Leronlimab PRO 140	CCR HIV	Infection Cancer
Leronlimab (PRO 140) is a humanized IgG4 *anti-CCR5* monoclonal antibody. Leronlimab inhibits CCR5-mediated HIV-1 viral and lung metastasis in mouse tumor models. Leronlimab can be used for the research of HIV nonalcoholic steatohepatitis (NASH) and cancer .

HY-149928

NNRT-IN-1	HIV	Infection
NNRTIs-IN-1 is a potent non-nucleoside reverse transcriptase inhibitor featuring significantly anti-resistance efficacy. NNRTIs-IN-1 inhibits the wild-type HIV-1 and five mutant strains with EC₅₀s in the nanomolar range. NNRTIs-IN-1 displays favorable pharmacokinetic properties .

HY-N0554

Escin IA	HIV Protease	Infection Cancer
Escin IA is a triterpene saponin isolated from Aesculus hippocastanum, which inhibits HIV-1 protease with IC₅₀ values of 35 μM. Escin IA has anti-TNBC metastasis activity, and its action mechanisms involved inhibition of epithelial-mesenchymal transition process by down-regulating LOXL2 expression .

HY-A0097

Teicoplanin 1 Publications Verification antibiotic MDL-507; MDL-507	Bacterial Antibiotic	Infection
Teicoplanin is a glycopeptide antibiotic indicated for use in serious infections caused by Gram-positive bacteria, including Methicillin-resistant Staphylococcus aureus and Enterococcus aureus.Teicoplanin shows antiviral activity for HIV-1, SARS-CoV1 and SARS-CoV2. Teicoplanin sodium shows anti-MRSA activity .

HY-15353

Emivirine MKC-442	HIV	Infection Inflammation/Immunology
Emivirine (MKC-442) is a non-nucleoside reverse transcriptase inhibitors (NNRTIs) with K_i values of 0.20 and 0.01 μM for dTTP- and dGTP-dependent DNA or RNA polymerase activity, respectively. Emivirine displays potent and selective anti-human immunodeficiency virus type 1 (HIV-1) activity .

HY-A0097A

Teicoplanin sodium antibiotic MDL-507 sodium; MDL-507 sodium	Antibiotic HIV SARS-CoV	Infection
Teicoplanin sodium is a glycopeptide antibiotic indicated for use in serious infections caused by Gram-positive bacteria, including Methicillin-resistant Staphylococcus aureus and Enterococcus aureus.Teicoplanin sodium shows antiviral activity for HIV-1, SARS-CoV1 and SARS-CoV2. Teicoplanin sodium shows anti-MRSA activity .

HY-144731

gp120-IN-2	HIV	Inflammation/Immunology
gp120-IN-2 (compound 4i) is a potent HIV-1 gp120 inhibitor with an IC₅₀ of 7.5 µM and CC₅₀ of 112.93 µM. gp120-IN-2 shows anti-HIV-1 activity. gp120-IN-2 shows cytotoxicity in a dose dependent manner in SUP-T1 cells .

Cat. No.	Product Name	Type

HY-116282

Dextran sulfate sodium salt (MW 5000)

1 Publications Verification

DSS (MW 5000); DXS (MW 5000)

Carbohydrates

Dextran sulfate sodium salt (DSS) (MW 5000) is a polymer of dehydrated glucose with a molecular weight of approximately 5000. Dextran sulfate sodium salt (DSS) with different molecular weights exhibits different biological activities. Dextran sulfate sodium salt (MW 5000) is an inhibitor of complement and coagulation pathways, and belongs to the glycosaminoglycans (GAG) family. Dextran sulfate sodium salt (MW 5000) acts as an anticoagulant, antiviral, and anti-lipemic agent. Dextran sulfate sodium salt (DSS) stops HIV-1 virus adsorption to host cells. Dextran sulfate sodium salt (MW 5000) prevents NK cell-mediated cytotoxicity. Dextran sulfate sodium salt (MW 5000) inhibits instant blood-mediated inflammatory reaction (IBMIR) .

Cat. No.	Product Name	Target	Research Area

HY-P10517A

Sifuvirtide acetate SFT acetate	HIV	Infection
Sifuvirtide (SFT) acetate is a potent *HIV* fusion inhibitor. Sifuvirtide acetate inhibits *HIV-1* mediated cell fusion in a dose-dependent manner and is highly potent against infection by primary and laboratory-adapted *HIV-1* isolates of multiple genotypes. Sifuvirtide acetate can be used in the research of anti-HIV drugs .

HY-P0052A

Enfuvirtide acetate 3 Publications Verification T20 acetate; DP178 acetate	HIV	Infection
Enfuvirtide (T20; DP178) acetate is an anti-HIV-1 fusion inhibitor peptide.

HY-P0052

Enfuvirtide 3 Publications Verification T20; DP178	HIV	Infection
Enfuvirtide (T20;DP178) is an anti-HIV-1 fusion inhibitor peptide.

HY-P1586

HIV-1 Rev (34-50) HIV-1 rev Protein (34-50)	HIV	Infection
HIV-1 Rev (34-50) is a 17-aa peptide derived from the Rev-responsive element (RRE)-binding domains of Rev in HIV-1, with anti-HIV-1 activity.

HY-P10517

Sifuvirtide SFT	HIV	Infection
Sifuvirtide (SFT) is a potent *HIV* fusion inhibitor. Sifuvirtide inhibits *HIV-1* mediated cell fusion in a dose-dependent manner and is highly potent against infection by primary and laboratory-adapted *HIV-1* isolates of multiple genotypes. Sifuvirtide can be used in the research of anti-HIV drugs .

HY-A0162R

Quinupristin (Standard)	Antibiotic Bacterial	Infection
Bictegravir (sodium) (Standard) is the analytical standard of Bictegravir (sodium). This product is intended for research and analytical applications. Bictegravir sodium is a potent inhibitor of HIV-1 integrase, with an IC50 of 7.5 nM. Bictegravir sodium exhibits potent and selective anti-HIV activity and low cytotoxicity .

HY-P4810

Polyphemusin II-Derived Peptide T140	CXCR	Infection
Polyphemusin II-Derived Peptide (T140), a CXCR4 inhibitor, shows high inhibitory activity against HIV-1 entry and the inhibitory effect on the binding of an anti-CXCR4 monoclonal antibody (12G5) to CXCR4 .

HY-P1757

HIV p17 Gag (77-85)	HIV	Infection
HIV p17 Gag (77-85) is an HLA-A0201(A2)-restricted CTL epitope, used in the research of anti-HIV .*

Cat. No.	Product Name	Target	Research Area

HY-P99697

Leronlimab PRO 140	CCR HIV	Infection Cancer
Leronlimab (PRO 140) is a humanized IgG4 *anti-CCR5* monoclonal antibody. Leronlimab inhibits CCR5-mediated HIV-1 viral and lung metastasis in mouse tumor models. Leronlimab can be used for the research of HIV nonalcoholic steatohepatitis (NASH) and cancer .

HY-P99584

Suvizumab KD-247	HIV	Infection
Suvizumab (KD-247) is an neutralizing antibody anti-HIV-1. Suvizumab effectively neutralizes HIV-1_MN, HIV-1_SF2 and HIV-1_89.6 with IC₅₀ values of 0.1 µg/mL, 1.0 µg/mL and 0.2 µg/mL, respectively. Suvizumab reduces the viral load of HIV. Suvizumab has good tolerance and can be used to prevent HIV infection .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N2010

Methyl gallate 1 Publications Verification Gallincin; NSC 363001	Infection Cardiovascular Disease Structural Classification Paeonia lactiflora Pall. Classification of Application Fields Source classification Phenols Polyphenols Plants Paeoniaceae Disease Research Fields	Bacterial HIV Reactive Oxygen Species
Methyl gallate is a plant phenolic with antioxidant, anticancer, and anti-inflammatory activities. Methyl gallate also shows bacterial inhibition activity. Methyl gallate also has anti-HIV-1 and *HIV-1* enzyme inhibitory activities.

HY-N1372A

Fangchinoline 5+ Cited Publications	Stephania tetrandra S. Moore Infection Alkaloids Structural Classification Monophenols Classification of Application Fields Source classification Phenols Plants Isoquinoline Alkaloids Menispermaceae Disease Research Fields	HIV FAK Apoptosis Autophagy
Fangchinoline is isolated from Stephania tetrandra with extensive biological activities, such as enhancing immunity, anti-inflammatory sterilization and anti-atherosclerosis. Fangchinoline, a novel *HIV-1* inhibitor, inhibits HIV-1 replication by impairing gp160 proteolytic processing . Fangchinoline targets Focal adhesion kinase (FAK) and suppresses FAK-mediated signaling pathway in tumor cells which highly expressed FAK . Fangchinoline induces apoptosis and adaptive autophagy in bladder cancer .

HY-19827

Aeroplysinin 1 (+)-Aeroplysinin-1	Structural Classification Anti-inflammation/Immunoregulatory Classification of Application Fields Source classification Marine natural products Antibacterial Disease Research Other Antibiotics Infection Animals Antibiotics Antiviral Sponge Anticancer Disease Research Fields	Bacterial HIV Apoptosis
Aeroplysinin 1 ((+)-Aeroplysinin-1), a secondary metabolite isolated from marine sponges, shows potent antibiotic effects on Gram-positive bacteria and exerts antiviral activity against *HIV-1* (IC₅₀=14.6 μM). Aeroplysinin 1 has anti-inflammatory, anti-angiogenic and anti-tumor activities. Aeroplysinin 1 induces apoptosis in endothelial cells .

HY-N0554

Escin IA	Infection Triterpenes Structural Classification other families Classification of Application Fields Terpenoids Hippocastanaceae Aesculus hippocastanum Source classification Plants Disease Research Fields Cancer	HIV Protease
Escin IA is a triterpene saponin isolated from Aesculus hippocastanum, which inhibits HIV-1 protease with IC₅₀ values of 35 μM. Escin IA has anti-TNBC metastasis activity, and its action mechanisms involved inhibition of epithelial-mesenchymal transition process by down-regulating LOXL2 expression .

HY-A0097

Teicoplanin 1 Publications Verification antibiotic MDL-507; MDL-507	Infection Structural Classification Microorganisms Source classification Polyphenols Disease Research Fields	Bacterial Antibiotic
Teicoplanin is a glycopeptide antibiotic indicated for use in serious infections caused by Gram-positive bacteria, including Methicillin-resistant Staphylococcus aureus and Enterococcus aureus.Teicoplanin shows antiviral activity for HIV-1, SARS-CoV1 and SARS-CoV2. Teicoplanin sodium shows anti-MRSA activity .

HY-N1111

Uncaric acid 6β,19α-Dihydroxyursolic acid	Triterpenes Structural Classification Terpenoids Source classification Rosaceae Plants Eriobotrya japonica (Thunb.) Lindl.	HIV
Uncaric acid (6β,19α-Dihydroxyursolic acid) (compound 6) is a triterpene that can be found in Eriobotrya japonica. Uncaric acid shows anti HIV-1, HRV 1B, SNV activity .

HY-N1372AR

Fangchinoline (Standard)	Stephania tetrandra S. Moore Alkaloids Structural Classification Monophenols Source classification Phenols Plants Isoquinoline Alkaloids Menispermaceae	HIV FAK Apoptosis Autophagy
Fangchinoline (Standard) is the analytical standard of Fangchinoline. This product is intended for research and analytical applications. Fangchinoline is isolated from Stephania tetrandra with extensive biological activities, such as enhancing immunity, anti-inflammatory sterilization and anti-atherosclerosis. Fangchinoline, a novel HIV-1 inhibitor, inhibits HIV-1 replication by impairing gp160 proteolytic processing . Fangchinoline targets Focal adhesion kinase (FAK) and suppresses FAK-mediated signaling pathway in tumor cells which highly expressed FAK . Fangchinoline induces apoptosis and adaptive autophagy in bladder cancer .

HY-N2010R

Methyl gallate (Standard)	Structural Classification Paeonia lactiflora Pall. Source classification Phenols Polyphenols Plants Paeoniaceae	Bacterial HIV Reactive Oxygen Species
Methyl gallate (Standard) is the analytical standard of Methyl gallate. This product is intended for research and analytical applications. Methyl gallate is a plant phenolic with antioxidant, anticancer, and anti-inflammatory activities. Methyl gallate also shows bacterial inhibition activity. Methyl gallate also has anti-HIV-1 and HIV-1 enzyme inhibitory activities.

HY-118747

Scirpusin A	Structural Classification Caragana rosea Turcz. ex Maxim. Source classification Phenols Polyphenols Plants Fabaceae	HIV
Scirpusin A is a naturally occurring compound extracted from the legume plant Caragana rosea Turcz, exhibiting anti-HIV activity. Scirpusin A demonstrates significant inhibitory effects against *HIV-1* (EC₅₀=7 μg/mL). Scirpusin A is utilized in research towards the development of anti-HIV therapeutics .

HY-N11097

FK-3000	Structural Classification Alkaloids Piperidine Alkaloids Source classification Plants Stephania delavayi Diels Menispermaceae	Apoptosis HSV HIV
FK-3000 is a potent anti-tumor agent that inhibits the growth of carcinoma cells through apoptosis and induction cell cycle arrest. FK-3000 also exhibit antiviral effects against HSV-1 and *HIV-1* .

HY-A0097A

Teicoplanin sodium antibiotic MDL-507 sodium; MDL-507 sodium	Structural Classification Source classification Phenols Polyphenols Endogenous metabolite	Antibiotic HIV SARS-CoV
Teicoplanin sodium is a glycopeptide antibiotic indicated for use in serious infections caused by Gram-positive bacteria, including Methicillin-resistant Staphylococcus aureus and Enterococcus aureus.Teicoplanin sodium shows antiviral activity for HIV-1, SARS-CoV1 and SARS-CoV2. Teicoplanin sodium shows anti-MRSA activity .

HY-N2571

Corydine	Infection Alkaloids Monophenols other families Classification of Application Fields Source classification Phenols Plants Isoquinoline Alkaloids Disease Research Fields	Reverse Transcriptase HIV
Corydine is a naturally occurring alkaloid which can be extracted from plants such as Croton echinocarpus leaves. Corydine is efficient on inhibiting reverse transcriptase (RT) activity with an IC₅₀ of 356.8 μg/mL. Corydine displays significant in vitro anti-HIV potential, inhibiting 40% of the HIV-1 reverse transcriptase enzyme activity at a concentration of 450 μg/mL of Corydine .

HY-N0554R

Escin IA (Standard)	Triterpenes Structural Classification other families Terpenoids Hippocastanaceae Aesculus hippocastanum Source classification Plants	HIV Protease
Escin IA (Standard) is the analytical standard of Escin IA. This product is intended for research and analytical applications. Escin IA is a triterpene saponin isolated from Aesculus hippocastanum, which inhibits HIV-1 protease with IC50 values of 35 μM. Escin IA has anti-TNBC metastasis activity, and its action mechanisms involved inhibition of epithelial-mesenchymal transition process by down-regulating LOXL2 expression .

HY-N6711

Equisetin	Infection Structural Classification Microorganisms Classification of Application Fields Antibiotics Source classification Antibacterial Disease Research Disease Research Fields Other Antibiotics	HIV Integrase Bacterial Antibiotic Reactive Oxygen Species STAT AMPK 11β-HSD
Equisetin is an N-methylserine-derived acyl tetramic acid, quorum sensing inhibitor (QSI), herbicides and antibiotics. Equisetin specifically inhibits the anionic carriers of substrates in the inner mitochondrial membrane. Equisetin inhibits the activity of HIV-1 integrase, 11β-HSD1, and 2,4-dinitrophenol (Dnp)-stimulated ATPase (IC₅₀ = ~8 nmol per mg of protein). Equisetin exhibits growth inhibition of bacteria, anti-inflammatory, amelioration of lipid-associated disorders, and cytotoxic effects .

HY-15310

Ivermectin Maximum Cited Publications 30 Publications Verification MK-933; CD-5024; K-237	Structural Classification Microorganisms Macrolide Antibiotics Classification of Application Fields Antibiotics Source classification Antiviral Anti-parasitic Disease Research Disease Research Fields Cancer	Flavivirus Dengue Virus Parasite HIV Mitophagy HSV SARS-CoV Antibiotic Autophagy Bacterial
Ivermectin (MK-933) is a broad-spectrum anti-parasite agent. Ivermectin (MK-933) is a specific inhibitor of Impα/β1-mediated nuclear import and has potent antiviral activity towards both HIV-1 and dengue virus. It is a positive allosteric effector of P2X₄ and the α7 neuronal nicotinic acetylcholine receptor (nAChRs). Ivermectin also inhibits bovine herpesvirus1 (BoHV-1) replication and inhibits BoHV-1 DNA polymerase nuclear import . Ivermectin is a candidate therapeutic against SARS-CoV-2/COVID-19 .

HY-15310R

Ivermectin (Standard)	Structural Classification Microorganisms Macrolide Antibiotics Antibiotics Source classification Antiviral Anti-parasitic Disease Research	Dengue Virus Flavivirus Parasite HIV Mitophagy HSV SARS-CoV Antibiotic Autophagy Bacterial
Ivermectin (Standard) is the analytical standard of Ivermectin. This product is intended for research and analytical applications. Ivermectin (MK-933) is a broad-spectrum anti-parasite agent. Ivermectin (MK-933) is a specific inhibitor of Impα/β1-mediated nuclear import and has potent antiviral activity towards both HIV-1 and dengue virus. It is a positive allosteric effector of P2X₄ and the α7 neuronal nicotinic acetylcholine receptor (nAChRs). Ivermectin also inhibits bovine herpesvirus1 (BoHV-1) replication and inhibits BoHV-1 DNA polymerase nuclear import . Ivermectin is a candidate therapeutic against SARS-CoV-2/COVID-19 .

HY-116931

Kelletinin I	Structural Classification Animals Source classification Phenols Polyphenols	Others
Kelletinin I is a coumarin compound with anti-HIV-1 activity.

HY-N1352

Rhuscholide A	Structural Classification Natural Products Monophenols Rhus chinensis Mill. Source classification Phenols Plants Anacardiaceae	HIV
Rhuscholide A is a benzofuran lactone that shows significant anti-HIV-1 activity, with an EC₅₀ of 1.62 μM .

HY-N10958

Wikstrol A	Structural Classification Flavonols Flavonoids Microorganisms Source classification	Fungal HIV Microtubule/Tubulin
Wikstrol A is a potent antifungal, antimitotic and anti-HIV-1 Agent. Wikstrol A induces morphological deformation of P. oryzae mycelia with an MMDC value of 70.1 µM. Wikstrol A shows activity against microtubule polymerization with an IC₅₀ value of 131 µM. Wikstrol A shows anti-HIV-1 activity with an IC₅₀ value of 67.8 µM .

HY-N0556

Isoescin IA	Other Terpenoids Infection Aesculus chinensis Bunge Classification of Application Fields Terpenoids Hippocastanaceae Source classification Plants Disease Research Fields	HIV Protease
Isoescin IA is a triterpenoid saponin isolated from the seeds of Aesculus chinensis. Isoescin IA has anti-HIV-1 protease activity .

HY-N12047

Schineolignin C	Structural Classification Source classification Phenols Polyphenols Plants Schisandraceae Schisandra chinensis (Turcz.) Baill.	HIV
Schineolignin C is a Lignan that can be isolated from the fruit of schisandra chinensis. schisandra chinensis has antihepatitis, antitumor, and anti-HIV-1 activities .

HY-N12046

Schineolignin B	Structural Classification Monophenols Source classification Phenols Plants Schisandraceae Schisandra chinensis (Turcz.) Baill.	HIV
Schineolignin B is a Lignan that can be isolated from the fruit of schisandra chinensis. schisandra chinensis has antihepatitis, antitumor, and anti-HIV-1 activities .

HY-N10934

Ganoderic acid GS-1	Triterpenes Structural Classification Microorganisms Terpenoids Source classification	HIV Protease
Ganoderic acid GS-1, a highly oxygenated lanostane-type triterpenoid, has anti-HIV-1 protease activities with an IC₅₀ of 58 μM .

HY-W707365

Docosyl trans-ferulate	Structural Classification Monophenols Zingiber mekongense Gagnep. Source classification Phenols Plants Zingiberaceae	HIV
Docosyl trans-ferulate (compound 2) is an antiviral compound. Docosyl trans-ferulate exhibits anti-HIV-1 activity in anti-syncytial assays using the ^ΔTat/revMC99 virus and 1A2 cell line systems .

HY-113818

Kadsuracoccinic acid A	Structural Classification Natural Products Source classification Plants Kadsura coccinea (Lem.) A. C. Smith Schisandraceae	HIV
Kadsuracoccinic acid A is a tetracyclic natural compound that can be isolated from the stems of Kadsura coccinea. Kadsuracoccinic acid A has vitro *anti-HIV-1* activitiy with an EC₅₀ value of 68.7 μM .

HY-N3502

20(21)-Dehydrolucidenic acid A	Infection Triterpenes Classification of Application Fields Terpenoids Source classification Polyporaceae Plants Disease Research Fields	HIV Protease
20(21)-Dehydrolucidenic acid A is a triterpenoid isolated from the fruiting body of the fungus Ganoderma sinense. 20(21)-Dehydrolucidenic acid A has weak anti-HIV-1 protease activity .

HY-116529

Lamellarin E	Structural Classification Alkaloids Microorganisms Other Alkaloids Source classification	Others
Lamellarin E is a biologically active marine alkaloid, while the Lamellarin series of alkaloids show potential cytotoxicity, topoisomerase I inhibition, protein kinase inhibition, multidrug resistance reversal, and anti-HIV-1 activity .

HY-N12345

5-Dexyexcoecafolin B	Triterpenes Structural Classification Excoecaria acertiflia Didr Terpenoids Source classification Euphorbiaceae Plants	Others
5-Dexyexcoecafolin B is a tigliane-type diterpenoid isolated from the EtOAc extract of Excoecaria acerifolia Didr. 5-Dexyexcoecafolin B has anti-HIV-1 activity with a EC₅₀ value of 0.036 μM .

HY-N0556R

Isoescin IA (Standard)	Other Terpenoids Aesculus chinensis Bunge Structural Classification Terpenoids Hippocastanaceae Source classification Plants	HIV Protease
Isoescin IA (Standard) is the analytical standard of Isoescin IA. This product is intended for research and analytical applications. Isoescin IA is a triterpenoid saponin isolated from the seeds of Aesculus chinensis. Isoescin IA has anti-HIV-1 protease activity .

HY-N10801

Salvianan A	Structural Classification Terpenoids Labiatae Source classification Samanea saman (Jacq.) Merr. Magnoliaceae Phenols Diterpenoids Plants	HIV
1,6,11-Trimethyl-1,2-dihydrofuro[2',3':1,2]phenanthro[4,3-d]oxazole (compound 1) is a potent *anti-HIV-1* agent .

HY-105231

Bryostatin 1 2 Publications Verification	Structural Classification Anti-inflammation/Immunoregulatory Neurological Disease Classification of Application Fields Marine natural products Source classification Other marine organisms Disease Research Infection Macrolide Antibiotics Animals Antibiotics Anticancer Inflammation/Immunology Disease Research Fields	PKC HIV Bacterial
Bryostatin 1 is a natural macrolide isolated from the bryozoan Bugula neritina and is a potent and central nervous system (CNS)-permeable PKC modulator. Bryostatin 1 binds to the isolated C1 domain of Munc13-1 and the full-length Munc13-1 protein with K_is of 8.07 nM and 0.45 nM, respectively. Bryostatin 1 has anti-cancer, anti-inflammatory, neuroprotective, anti-HIV-1 infection properties .

HY-N6924

Zingibroside R1	Infection Structural Classification Panax notoginseng (Burkill) F. H. Chen ex C. H. Chow Classification of Application Fields Panax japonicas C. A. Mey. Source classification Metabolic Disease Plants Disease Research Fields Saccharides Araliaceae	HIV
Zingibroside R1 is dammaranae-type triterpenoid saponin, isolated from rhizomes, taproots, and lateral roots of Panax japonicas C. A. Meyer, shows excellent anti-tumor effects as well as anti-angiogenic activity . Zingibroside R1 possesses some anti-HIV-1 activity. Zingibroside R1 has inhibitory effects on the 2-deoxy-D-glucose (2-DG) uptake by EAT cells (IC₅₀=91.3 μM) .

HY-N3094

Periglaucine A	Structural Classification Alkaloids Pyrrole Alkaloids Labiatae Source classification Plants Erigeron breviscapus (Vant.) Hand.-Mazz.	HBV HIV
Periglaucine A, a hasubanane-type alkaloid, can be isolated from Pericampylus glaucus. Periglaucine A can inhibits HBV surface antigen (HBsAg) secretion in Hep G2.2.15 cells. Periglaucine A also shows anti-HIV-1 activity in C8166 cells (EC₅₀: 204 μM) .

HY-N2996

Ganodermanondiol	Infection Triterpenes Structural Classification Microorganisms Classification of Application Fields Terpenoids Polyporaceae Source classification Ganoderma lucidum (Leyss. Ex Fr.) Karst. Plants Disease Research Fields	HIV Protease
Ganodermanondiol is a melanogenesis inhibitor isolated from the Ganoderma lucidum .Ganodermanondiol exhibits potent cytoprotective effects on tert-butyl hydroperoxide-induced hepatotoxicity . Ganodermanondiol shows significant anti-HIV-1 protease activity with an IC₅₀ of 90 μM . Ganodermanondiol exhibits a strong anticomplement activity against the classical pathway of the complement system with an IC₅₀ of 41.7μM .

HY-N0867

13-Oxyingenol-13-dodecanoate	Structural Classification Classification of Application Fields Terpenoids Gramineae Source classification Other Diseases Diterpenoids Leptochloa chinensis (Linn.) Nees Plants Disease Research Fields	HIV ULK Bcl-2 Family
13-Oxyingenol-dodecanoate (13OD) is a tumor suppressor agent. 13-Oxyingenol-dodecanoate has anti-HIV-1 activity with EC₅₀ value of 33.7 nM .13-Oxyingenol-dodecanoate can induce the expression of ULK1 to effect mitochondrial dysfunction and cellular autophagy. 13-Oxyingenol-dodecanoate also increases the expression of BAX and suppresses the expression of BCL-2 to effect apoptosis .

Cat. No.	Compare	Product Name	Species	Source

HY-P704059

	Rev Protein, HIV-1 group M subtype C (GST) rev; Protein Rev; ART/TRS; anti-repression transactivator; Regulator of expression of viral proteins	Virus	E. coli

Compare Products


Products	In-stock - + Add to Cart
Cat. No.
Species
Source
Tag
Accession
Gene ID
Molecular Weight
Purity
Endotoxin Level
Biological Activity
Appearance
Formulation
Storage & Stability
Shipping
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Product Name	Chemical Structure

HY-12687S

Tizoxanide-d4
Tizoxanide-d₄ is the deuterium labeled Tizoxanide. Tizoxanide is the active metabolite of Nitazoxanide, which is a thiazolide anti-infective compound against anaerobic bacteria, protozoa, and a range of viruses. Tizoxanide has anti-HIV-1 activities[1][2].

Cat. No.	Product Name		Classification

HY-125810

4'-Ethynyl-2'-deoxyadenosine		Alkynes
4'-Ethynyl-2'-deoxyadenosine (4'-E-dA), a nucleoside reverse transcriptase (RT) inhibitor, is an antiretroviral agent which is potent against drug-resistant HIV variants, with an EC₅₀ of 98 nM in MT-4 cells for anti-HIV-1 activity . 4'-Ethynyl-2'-deoxyadenosine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks