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Results for "

thromboxanes

" in MedChemExpress (MCE) Product Catalog:

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122

Inhibitors & Agonists

Biochemical Assay Reagents

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-120980

Thromboxane B1 TXB1	Prostaglandin Receptor	Cardiovascular Disease
Thromboxane B1 (TXB1) is one of thromboxane B (TXB) family members. Thromboxane is a member of the family of lipids known as eicosanoids. Thromboxane is named for its role in blood clot formation (thrombosis) .

HY-A0221

Ridogrel R 68070	Prostaglandin Receptor	Inflammation/Immunology
Ridogrel (R 68070) is an orally active *combined thromboxane* A2 synthetase** inhibitor and thromboxane A2/prostaglandin endoperoxide receptor blocker. Ridogrel is potent antiplatelet agent. Anti-inflammatory activities .

HY-125781

*Carbocyclic thromboxane* A2** CTA2	Prostaglandin Receptor	Endocrinology
Carbocyclic thromboxane A2 (CTA2) is a thromboxane A2 analog. Carbocyclic thromboxane A2 causes an increase in [ ³ H]thymidine incorporation and cell number and enhances the angiotensin II-induced DNA synthesis in smooth muscle cells .

HY-106066

Dazmegrel UK38485	Prostaglandin Receptor	Cardiovascular Disease
Dazmegrel (UK-38485) is a thromboxane synthetase inhibitor which inhibits Thromboxane A2 (TXA2) synthesis and exhibits antiplatelet vasodilator effects. Dazmegrel can be utilized in thrombosis research .

HY-124353

*11-Dehydro thromboxane* B3** 11-Dehydro-TXB3	Endogenous Metabolite	Others
11-Dehydro thromboxane B3 (11-Dehydro-TXB3) is a urinary metabolite of Thromboxane A3 (TXA3) .

HY-105114

Imitrodast	Cytochrome P450	Inflammation/Immunology
Imitrodast is an inhibitor of thromboxane synthase. Imitrodast can be used in the research of bronchoconstriction .

HY-10419A

AH23848 hemicalcium salt	Prostaglandin Receptor	Cardiovascular Disease
AH23848 hemicalcium salt is a potent, specific and orally active thromboxane receptor blocker. AH23848 hemicalcium salt inhibits platelet deposition .

HY-129614

LG 82-4-01	Prostaglandin Receptor	Metabolic Disease
LG 82-4-01 is a thromboxane (TX) synthetase specific inhibitor, with an IC₅₀ of 1.3 μM .

HY-116281

ICI D1542	Prostaglandin Receptor	Cardiovascular Disease
ICI D1542 is a selective and potent inhibitor of thromboxane A2 (TXA2) synthase and the thromboxane A2 receptor (TP-receptor). ICI D1542 is effective at preventing thrombus formation by redirection of arachidonic acid metabolism .

HY-123293

UK 34787	Prostaglandin Receptor	Cardiovascular Disease
UK 34787 is a selective thromboxane synthetase inhibitor with little or no activity against cyclooygenase or prostacyclin synthetase .

HY-136500

Prostaglandin H2 PGH2	Endogenous Metabolite	Cardiovascular Disease
Prostaglandin H2 (PGH2), a potent vasoconstrictor, is produced by the conversion of Arachidonic acid (AA). Prostaglandin H2 is asubstrate for the production of Prostaglandins (PGs) and thromboxanes (TXs) .

HY-123328

AGN 191976	Prostaglandin Receptor	Cardiovascular Disease
AGN 191976 is a potent and selective thromboxane A₂-sensitive (TP) receptor agonist with EC₅₀ values of 0.23 nM and 24 nM in rat aorta and human platelets, respectively. AGN 191976 has potent IOP-lowering effects in dogs and monkeys. AGN 191976 can be used to study vascular biology and the role of thromboxane A₂ in vascular function .

HY-108972

SQ 29548	Prostaglandin Receptor	Metabolic Disease
SQ 29548, a high affinity radioligand, is a selective thromboxane-prostanoid (TP) receptor antagonist .

HY-119410

Linotroban HN11500	Prostaglandin Receptor	Cardiovascular Disease
Linotroban (HN11500), a Sulotroban (HY-158332) derivative, is an orally active, potent non-prostanoid thromboxane receptor antagonist (TXRA) with a strong antiplatelet profile. Linotroban is used as antithrombotic agent .

HY-120178

(±)7(8)-DiHDPA	COX	Cardiovascular Disease
(±)7(8)-DiHDPA is a epoxygenase metabolite of docosahexaenoic acid (HY-B2167). (±)7(8)-DiHDPA inhibits platelet aggregation at concentrations below those affecting thromboxane synthesis .

HY-19249

Z-335 sodium	Prostaglandin Receptor	Metabolic Disease Inflammation/Immunology
Z-335 sodium is an orally active thromboxane a₂ (TXA₂) receptor antagonist, with IC₅₀ values of 29.9 nM and 32.5 nM for human and Guinea pig platelets, respectively .

HY-120442

(±)16(17)-DiHDPA	COX	Cardiovascular Disease
(±)16(17)-DiHDPA is a epoxygenase metabolite of docosahexaenoic acid (HY-B2167). (±)16(17)-DiHDPA inhibits platelet aggregation at concentrations below those affecting thromboxane synthesis .

HY-160664

TP receptor antagonist-2	Prostaglandin Receptor	Cardiovascular Disease
TP receptor antagonist-2 (example 7n) is a thromboxane A₂ receptor (TP receptor) antagonist, with IC₅₀ values of 5.64 and 5.27 μM for TPα and TPβ, respectively. TP receptor antagonist-2 inhibits platelet aggregation .

HY-B0428B

Ozagrel hydrochloride 1 Publications Verification OKY-046 hydrochloride	Prostaglandin Receptor	Cardiovascular Disease
Ozagrel hydrochloride (OKY-046 hydrochloride) is a thromboxane A2 (TXA2) synthase inhibitor. Ozagrel hydrochloride is an antiplatelet agent, which selectively inhibits human platelet aggregationwith an IC₅₀ of 53.12 μM .

HY-B0428A

Ozagrel sodium 1 Publications Verification OKY-046 sodium	Prostaglandin Receptor	Cardiovascular Disease
Ozagrel sodium (OKY-046 sodium) is a thromboxane A2 (TXA2) synthase inhibitor. Ozagrel sodium is an antiplatelet agent, which selectively inhibits human platelet aggregation with an IC₅₀ of 53.12 μM .

HY-116560

ONO-8809	Histamine Receptor	Inflammation/Immunology
ONO-8809 is a Thromboxane A2 receptor antagonist. ONO-8809 inhibits the LTC4-induced airway hyperresponsiveness to histamine in a dose-dependent manner .

HY-B0428

Ozagrel 1 Publications Verification OKY-046	Prostaglandin Receptor	Cardiovascular Disease
Ozagrel (OKY-046)is an anti-asthmatic agent and a thromboxane A2 (TXA2) synthase inhibitor. Ozagrel is an antiplatelet agent, which selectively inhibits human platelet aggregation with an IC₅₀ of 53.12 μM .

HY-B0428BR

Ozagrel (hydrochloride) (Standard)	Prostaglandin Receptor	Cardiovascular Disease
Ozagrel (hydrochloride) (Standard) is the analytical standard of Ozagrel (hydrochloride). This product is intended for research and analytical applications. Ozagrel hydrochloride (OKY-046 hydrochloride) is a thromboxane A2 (TXA2) synthase inhibitor. Ozagrel hydrochloride is an antiplatelet agent, which selectively inhibits human platelet aggregationwith an IC₅₀ of 53.12 μM .

HY-129496

NP-313	Thrombin	Cardiovascular Disease
NP-313 is a potent antithrombotic agent that inhibits platelet aggregation and activation. NP-313 has dual inhibition of thromboxane A 2 synthesis and selective inhibition of SOCC-mediated Ca ²⁺ inward flow .

HY-129851

NTP42	Prostaglandin Receptor	Cardiovascular Disease
NTP42 is a thromboxane A2 (TXA2) receptor antagonist with an IC₅₀ of 3.278 nM for antagonizing T prostanoid receptor (TP)- mediated [Ca ²⁺] mobilization following stimulation of cells with the alternative TP agonist U46619 . NTP42 can be used for the treatment of pulmonary arterial hypertension (PAH) .

HY-129786

LG 82-4-00	Prostaglandin Receptor	Cardiovascular Disease
LG 82-4-00 is a thromboxane (TX) synthase inhibitor with an IC₅₀ value of 1.1 μM. LG 82-4-00 can inhibit collagen-induced TXB₂ formation and platelet aggregation in plasma. LG 82-4-00 can be used in studies related to thrombotic diseases .

HY-105120A

Vapiprost hydrochloride GR 32191 hydrochloride	Prostaglandin Receptor	Others
Vapiprost hydrochloride (GR 32191 hydrochloride) is a thromboxane A2 receptor antagonist. Vapiprost hydrochloride (GR 32191 hydrochloride) inhibits the aggregation and ATP release stimulated with U-46619, collagen or arachidonic acid (AA) at an IC₅₀ of less than 2.1×10 ^-8 M .

HY-W273690

Pentifylline 1-Hexyltheobromine; Hexyltheobromine	Collagen	Cardiovascular Disease
Pentifylline is a vasodilator with anti-inflammatory activity. Pentifylline inhibits platelet aggregation and thromboxane A2 synthesis, reduces the release of free radicals, and decreases the production of type 1 collagen and laminin in fibroblasts. Pentifylline has the potential to be studied in acute ischemic stroke .

HY-114846

Ro 22-9194	Prostaglandin Receptor	Cardiovascular Disease
Ro 22-9194 inhibits aggregation and thromboxane Az (TXA2) synthetase activity in rabbit and human platelets. Ro 22-9194 has a potent inhibitory action against various types of model arrhythmias. Ro 22-9194 has non-cholinergic cardiac depressant properties with its vasodilating action .

HY-130304

8-Isoprostaglandin E2 iPE2-III	Prostaglandin Receptor	Cardiovascular Disease
8-Isoprostaglandin E2 (iPE2-III) is a member of the isoprostane class of prostanoids. 8-Isoprostaglandin E2 acts at the receptor for thromboxane A₂ (the TP) in vivo to induce vasoconstriction and platelet aggregation. 8-Isoprostaglandin E2 enhances receptor-activated NFkappa B ligand (RANKL)-dependent osteoclastic potential of marrow hematopoietic precursors via the cAMP pathway .

HY-106961

ONO 1301 ONO-AP 500-02	Prostaglandin Receptor	Cardiovascular Disease
ONO 1301 (ONO-AP 500-02), a prostaglandin (PG) I2 mimetic, is an orally active, long-acting prostacyclin agonist with thromboxane-synthase inhibitory activity. ONO 1301 promotes production of hepatocyte growth factor (HGF) from various cell types and ameliorates ischemia-induced left ventricle dysfunction in the mouse, rat and pig .

HY-113331S1

Thromboxane B2-d9	Isotope-Labeled Compounds Prostaglandin Receptor	Inflammation/Immunology
Thromboxane B2-d₉ is deuterium labeled Thromboxane B2. Thromboxane B2 is a prostaglandin derivative that is released during anaphylaxis. Thromboxane B2 induces arterial contraction and platelet aggregation .

HY-113331S

Thromboxane B2-d4	Isotope-Labeled Compounds	Inflammation/Immunology
Thromboxane B2-D4 is the deuterium labeled Thromboxane B2. Thromboxane B2 is a prostaglandin derivative that is released during anaphylaxis. Thromboxane B2 induces arterial contraction and platelet aggregation .

HY-113420S2

*11-Dehydro-thromboxane* B2-13C5**	Endogenous Metabolite Isotope-Labeled Compounds	Metabolic Disease
11-Dehydro-thromboxane B2- ¹³C₅ is ¹³C labeled 11-Dehydro-thromboxane B2 (HY-113420). 11-Dehydro-thromboxane B2 is a platelet hemagglutinin. Thromboxane inhibition was assessed by urinary excretion levels of 11-Dehydro-thromboxane B2. 11-Dehydro-thromboxane B2 can be used in the study of atherosclerotic thrombosis .

HY-113350

Thromboxane A2 TXA2	Prostaglandin Receptor Endogenous Metabolite	Inflammation/Immunology Endocrinology Cancer
Thromboxane A2 (TXA2) is a prostanoid mediator produced by the metabolism of Arachidonic acid (HY-109590) through the cyclooxygenase pathway. Thromboxane A2 activates the thromboxane-prostanoid (TP) receptors. Thromboxane A2 is a potent vasoconstrictor eicosanoid. Thromboxane A2 (TXA2) leads to potent vasoconstriction by stimulation of smooth muscle cells. Thromboxane A2 acts as s tonic immunoregulator to regulate adaptive immune responses .

HY-113420

*11-Dehydro-thromboxane* B2**	Endogenous Metabolite	Metabolic Disease
11-Dehydro-thromboxane B2 is a platelet hemagglutinin. Thromboxane inhibition was assessed by urinary excretion levels of 11-Dehydro-thromboxane B2. 11-Dehydro-thromboxane B2 can be used in the study of atherosclerotic thrombosis .

HY-160615

TP receptor antagonist-1	Prostaglandin Receptor	Cardiovascular Disease Inflammation/Immunology
TP receptor antagonist-1 (compound 7m) is a thromboxane A₂ receptor (TP receptor) antagonist, with IC₅₀ values of 9.46 μM for TPa and 8.49 μM for TPb, respectively. TP receptor antagonist-1 can be used for the research of cardiovascular disease .

HY-N0652

2,3,5,4'-Tetrahydroxystilbene 2-O-β-D-glucoside 1 Publications Verification 2,3,4',5-Tetrahydroxystilbene 2-O-D-glucoside	ERK NF-κB	Cardiovascular Disease Neurological Disease
2,3,5,4'-Tetrahydroxystilbene 2-O-β-D-glucoside isolats from the roots of Polygonaceae species, inhibits the formation of 5-HETE, HHT and thromboxane B2. 2,3,5,4'-Tetrahydroxystilbene 2-O-β-D-glucoside has hypotensive, anti-ageing, anti-inflammatory, hypolipidemic, cardioprotective, and neuroprotective actions .

HY-106961A

(Z)-ONO 1301 (Z)-ONO-AP 500-02	Prostaglandin Receptor	Cardiovascular Disease
(Z)-ONO 1301 is the isomer of ONO 1301 (HY-106961), and can be used as an experimental control. ONO 1301 (ONO-AP 500-02), a prostaglandin (PG) I2 mimetic, is an orally active, long-acting prostacyclin agonist with thromboxane-synthase inhibitory activity. ONO 1301 promotes production of hepatocyte growth factor (HGF) from various cell types and ameliorates ischemia-induced left ventricle dysfunction in the mouse, rat and pig .

HY-113331

Thromboxane B2	Prostaglandin Receptor	Inflammation/Immunology
Thromboxane B2 is a prostaglandin derivative that is released during anaphylaxis. Thromboxane B2 induces arterial contraction and platelet aggregation.

HY-120975

*2,3-Dinor thromboxane* b1**	Prostaglandin Receptor	Inflammation/Immunology
2,3-Dinor thromboxane b1 is an urinary metabolite of Thromboxane B2 (HY-113331) .

HY-113445

Thromboxane B3	COX Endogenous Metabolite	Endocrinology
Thromboxane B3 is a prostaglandin analog derived from arachidonic acid (AA) in the cyclooxygenase (COX) metabolic pathway. Thromboxane B3 is generated from arachidonic acid (AA) in platelets and vascular endothelial cells through the catalysis of cyclooxygenase (COX) and thromboxane synthase (TXS). Thromboxane B3 has been reported to be formed by human platelets upon ingestion of eicosapentaenoic acid (C20: 5ω3) .

HY-19189

Terbogrel BIBV 308SE	Prostaglandin Receptor	Cardiovascular Disease Endocrinology
Terbogrel is an orally available thromboxane A2 receptor antagonist and a thromboxane A2 synthase inhibitor, with both IC₅₀s of about 10 nM.

HY-126923

*2,3-Dinor thromboxane* B2** 2,3-Dinor-TXB2	Endogenous Metabolite	Cardiovascular Disease Metabolic Disease
2,3-Dinor thromboxane B2 (2,3-Dinor-TXB2), a metabolite of urine, serves as an indicator of the production of thromboxane A2 (TxA2) in the body, and can be used as a tool to study the role of thromboxane in various pathophysiological processes in the human body .

HY-113420S

*11-Dehydro-thromboxane* B2-d4**	Isotope-Labeled Compounds	Others
11-Dehydro-thromboxane B2-d₄ is the deuterium labeled 11-Dehydro-thromboxane B2[1].

HY-U00072

RS-601	Leukotriene Receptor Prostaglandin Receptor	Inflammation/Immunology Endocrinology
RS-601 is a novel *leukotriene D4 (LTD4)/thromboxane* A2 (TxA2)** dual receptor antagonist, with antiasthmatic activities.

HY-101692

AZ-1355	Prostaglandin Receptor	Metabolic Disease Endocrinology
AZ-1355 is an effctive lipid-lowering compound, which also inhibits platelet aggregation in vivo and elevates the prostaglandin I₂/thromboxane A₂ ratio in vitro.

HY-B1263

Chlorobutanol	Bacterial Fungal	Infection Neurological Disease
Chlorobutanol is an orally active and potent inhibitor of platelet aggregation and release and a pharmaceutical preservative with antibacterial activity. Chlorobutanol inhibits thromboxane B2 formation, ATP release, and elevation of cytosolic free calcium caused by collagen, ADP, epinephrine, arachidonic acid and thrombin. Chlorobutanol is active against a wide variety of Gram-positive and Gram-negative bacteria, and several mold spores and fungi. Chlorobutanol is widely used in food and cosmetic industry .

HY-N0652R

2,3,5,4'-Tetrahydroxystilbene 2-O-β-D-glucoside (Standard)	ERK NF-κB	Cardiovascular Disease Neurological Disease
2,3,5,4'-Tetrahydroxystilbene 2-O-β-D-glucoside (Standard) is the analytical standard of 2,3,5,4'-Tetrahydroxystilbene 2-O-β-D-glucoside. This product is intended for research and analytical applications. 2,3,5,4'-Tetrahydroxystilbene 2-O-β-D-glucoside isolats from the roots of Polygonaceae species, inhibits the formation of 5-HETE, HHT and thromboxane B2. 2,3,5,4'-Tetrahydroxystilbene 2-O-β-D-glucoside has hypotensive, anti-ageing, anti-inflammatory, hypolipidemic, cardioprotective, and neuroprotective actions .

HY-124150

BM567	Prostaglandin Receptor	Cardiovascular Disease
BM567 is a sulfonylurea compound (compound 1), which exhibits antithrombogenic efficacy as thromboxane A₂ receptor (TXR) antagonists and thromboxane A₂ synthase (TXS) inhibitors, with IC₅₀s of 1.1 and 12 nM, respectively .

Cat. No.	Product Name	Type

HY-D0837

Imidazole

2 Publications Verification

Glyoxaline; 1,3-Diaza-2,4-cyclopentadiene

Cell Assay Reagents

Imidazole (Glyoxaline; 1,3-Diaza-2,4-cyclopentadiene) is a heterocyclic aromatic compound. Imidazole bearing molecules have been used as corrosion, acetylcholinesterase (AChEI) and xanthine oxidase (XO) inhibitors, performing biological activities such as antifungal, antituberculosis, anti-inflammatory, antioxidant, and analgesic, amongst many others. Imidazole inhibits the enzymatic conversion of the endoperoxides (PGG₂ and PGH₂) to thromboxane A2 by platelet microsomes. Imidazole derivatives exhibits inhibition on SARS-CoV-2 3CL ^Pro enzyme, which is promising for research in the field of Alzheimer’s disease, gout, COVID-19 and thrombo-embolic disease .

HY-D0837R

Imidazole (Standard)

Cell Assay Reagents

Imidazole (Standard) is the analytical standard of Imidazole. This product is intended for research and analytical applications. Imidazole (Glyoxaline; 1,3-Diaza-2,4-cyclopentadiene) is a heterocyclic aromatic compound. Imidazole bearing molecules have been used as corrosion, acetylcholinesterase (AChEI) and xanthine oxidase (XO) inhibitors, performing biological activities such as antifungal, antituberculosis, anti-inflammatory, antioxidant, and analgesic, amongst many others. Imidazole inhibits the enzymatic conversion of the endoperoxides (PGG2 and PGH2) to thromboxane A2 by platelet microsomes. Imidazole derivatives exhibits inhibition on SARS-CoV-2 3CLPro enzyme, which is promising for research in the field of Alzheimer’s disease, gout, COVID-19 and thrombo-embolic disease .

HY-130444

PTA2 Pinanethromboxane A2	Carbohydrates
PTA2 (Pinane thromboxane A2) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-113420

*11-Dehydro-thromboxane* B2**	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
11-Dehydro-thromboxane B2 is a platelet hemagglutinin. Thromboxane inhibition was assessed by urinary excretion levels of 11-Dehydro-thromboxane B2. 11-Dehydro-thromboxane B2 can be used in the study of atherosclerotic thrombosis .

HY-N0652

2,3,5,4'-Tetrahydroxystilbene 2-O-β-D-glucoside 1 Publications Verification 2,3,4',5-Tetrahydroxystilbene 2-O-D-glucoside	Structural Classification Stilbenes Classification of Application Fields Polygonaceae Source classification Other Diseases Phenols Polyphenols Fallopia multiflora (Thunb.) Harald. Plants Disease Research Fields	ERK NF-κB
2,3,5,4'-Tetrahydroxystilbene 2-O-β-D-glucoside isolats from the roots of Polygonaceae species, inhibits the formation of 5-HETE, HHT and thromboxane B2. 2,3,5,4'-Tetrahydroxystilbene 2-O-β-D-glucoside has hypotensive, anti-ageing, anti-inflammatory, hypolipidemic, cardioprotective, and neuroprotective actions .

HY-N3617

Coniferin 1 Publications Verification Laricin	Infection Structural Classification Microorganisms other families Classification of Application Fields Simple Phenylpropanols Source classification Phenylpropanoids Plants Disease Research Fields	Fungal Prostaglandin Receptor
Coniferin (Laricin) is a glucoside of coniferyl alcohol. Coniferin inhibits fungal melanization. Coniferin inhibits the release of certain hormones from cells, including Prostaglandin E2 and Thromboxane B2 .

HY-N2391

p-Hydroxycinnamic acid	Structural Classification Monophenols Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Endogenous metabolite Disease Research Fields Endocrinology	Endogenous Metabolite Prostaglandin Receptor
p-Hydroxycinnamic acid, a common dietary phenol, could inhibit platelet activity, with IC₅₀s of 371 μM, 126 μM for thromboxane B₂ production and lipopolysaccharide-induced prostaglandin E₂ generation, respectively.

HY-120178

(±)7(8)-DiHDPA	Structural Classification Ketones, Aldehydes, Acids Source classification Endogenous metabolite	COX
(±)7(8)-DiHDPA is a epoxygenase metabolite of docosahexaenoic acid (HY-B2167). (±)7(8)-DiHDPA inhibits platelet aggregation at concentrations below those affecting thromboxane synthesis .

HY-113350

Thromboxane A2 TXA2	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields Endocrinology Cancer	Prostaglandin Receptor Endogenous Metabolite
Thromboxane A2 (TXA2) is a prostanoid mediator produced by the metabolism of Arachidonic acid (HY-109590) through the cyclooxygenase pathway. Thromboxane A2 activates the thromboxane-prostanoid (TP) receptors. Thromboxane A2 is a potent vasoconstrictor eicosanoid. Thromboxane A2 (TXA2) leads to potent vasoconstriction by stimulation of smooth muscle cells. Thromboxane A2 acts as s tonic immunoregulator to regulate adaptive immune responses .

HY-N0652R

2,3,5,4'-Tetrahydroxystilbene 2-O-β-D-glucoside (Standard)	Structural Classification Stilbenes Polygonaceae Source classification Phenols Polyphenols Fallopia multiflora (Thunb.) Harald. Plants	ERK NF-κB
2,3,5,4'-Tetrahydroxystilbene 2-O-β-D-glucoside (Standard) is the analytical standard of 2,3,5,4'-Tetrahydroxystilbene 2-O-β-D-glucoside. This product is intended for research and analytical applications. 2,3,5,4'-Tetrahydroxystilbene 2-O-β-D-glucoside isolats from the roots of Polygonaceae species, inhibits the formation of 5-HETE, HHT and thromboxane B2. 2,3,5,4'-Tetrahydroxystilbene 2-O-β-D-glucoside has hypotensive, anti-ageing, anti-inflammatory, hypolipidemic, cardioprotective, and neuroprotective actions .

HY-N5031

Mulberrofuran Q	other families Classification of Application Fields Source classification Phenols Polyphenols Plants Disease Research Fields Inflammation/Immunology	Others
Mulberrofuran Q inhibits the formation of 12-hydroxy-5,8,10-heptadecatrienoic acid (HHT) and thromboxane B2 (cyclooxygenase products) .

HY-N3617R

Coniferin (Standard) Laricin (Standard)	Structural Classification Microorganisms other families Simple Phenylpropanols Source classification Phenylpropanoids Plants	Fungal
Coniferin (Standard) is an analytical standard for Coniferin. This product is intended for research and analytical applications. Coniferin (Laricin) is a glucoside of coniferyl alcohol. Coniferin inhibits fungal melanization. Coniferin inhibits the release of certain hormones from cells, including Prostaglandin E2 and Thromboxane B2 .

HY-118736

Ganodermic acid S	Triterpenes Structural Classification Microorganisms Ketones, Aldehydes, Acids Terpenoids Source classification	Others
Ganodermic acid S is an oxygenated triterpenoid, that can be isolated from the Chinese medicinal fungus Ganoderma lucidum (Fr.) Karst (Polyporaceae). Ganodermic acid S exerts a concentration dependent inhibition on the response of human gel-filtered platelets (GFP) to U-46619 (HY-108566), a thromboxane (TX) A2 mimetic .

HY-W612338

9-Oxononanoic acid 9-ONA	Structural Classification Arachis hypogaea L. Leguminosae Ketones, Aldehydes, Acids Source classification Plants	Phospholipase Prostaglandin Receptor
9-Oxononanoic acid (9-ONA) is secondary reaction product of lipid peroxidation. 9-Oxononanoic acid induces phospholipase A2 (PLA2) activity and thromboxane A2 (HY-113350) production (TXA2). 9-Oxononanoic acid induces the platelet aggregation in human blood. 9-Oxononanoic acid is orally active .

HY-125122

Mulberrofuran A	Structural Classification Monophenols Source classification Phenols Morus alba L. Plants Moraceae	Others
Mulberrofuran A is a natural product, that can be isolated from the root bark of mulberry tree. Mulberrofuran A inhibits the formations of 12-hydroxy-,8,10-heptadecatrienoic acid (HHT) and thromboxane B2 (cyclooxygenase products), but it increases the formation of 12-hydroxy-5,8,10,14-eicosatetraenoic acid (12-HETE) (12-lipoxygenase product) .

Cat. No.	Product Name	Chemical Structure

HY-113331S1

Thromboxane B2-d9
Thromboxane B2-d₉ is deuterium labeled Thromboxane B2. Thromboxane B2 is a prostaglandin derivative that is released during anaphylaxis. Thromboxane B2 induces arterial contraction and platelet aggregation .

HY-113331S

Thromboxane B2-d4
Thromboxane B2-D4 is the deuterium labeled Thromboxane B2. Thromboxane B2 is a prostaglandin derivative that is released during anaphylaxis. Thromboxane B2 induces arterial contraction and platelet aggregation .

HY-113420S2

*11-Dehydro-thromboxane* B2-13C5**
11-Dehydro-thromboxane B2- ¹³C₅ is ¹³C labeled 11-Dehydro-thromboxane B2 (HY-113420). 11-Dehydro-thromboxane B2 is a platelet hemagglutinin. Thromboxane inhibition was assessed by urinary excretion levels of 11-Dehydro-thromboxane B2. 11-Dehydro-thromboxane B2 can be used in the study of atherosclerotic thrombosis .

HY-113420S

*11-Dehydro-thromboxane* B2-d4**
11-Dehydro-thromboxane B2-d₄ is the deuterium labeled 11-Dehydro-thromboxane B2[1].

HY-165674S

*11-dehydro-2,3-dinor Thromboxane* B2-d9**
11-dehydro-2,3-dinor Thromboxane B2-d₉ (11-dehydo-2,3-dio TXB2-d₉) is deuterium labeled 11-dehydro-2,3-dinor Thromboxane B2 .

HY-B0745S

Ramatroban-d4
Ramatroban-d₄ is deuterium labeled Ramatroban. Ramatroban is a selective thromboxane A2 (TxA2, IC50=14 nM) antagonist, which also antagonizes CRTH2 (IC50=113 nM) by inhibiting PGD2 binding.

HY-18763S

Indobufen-d5
Indobufen-d₅ is deuterium labeled Indobufen. Indobufen is a platelet aggregation inhibitor. Indobufen is a reversible platelet cyclooxygenase (Cox) activity inhibitor. Indobufen suppresses thromboxane A2 (TxA2) synthesis. Indobufen down-regulates tissue factor (TF) in monocytes[1].

HY-130304S

8-Isoprostaglandin E2-d4

8-Isoprostaglandin E2-d₄ (iPE2-III-d₄) is deuterium labeled 8-Isoprostaglandin E2. 8-Isoprostaglandin E2 (iPE2-III) is a member of the isoprostane class of prostanoids. 8-Isoprostaglandin E2 acts at the receptor for thromboxane A₂ (the TP) in vivo to induce vasoconstriction and platelet aggregation. 8-Isoprostaglandin E2 enhances receptor-activated NFkappa B ligand (RANKL)-dependent osteoclastic potential of marrow hematopoietic precursors via the cAMP pathway .

HY-W699983

Imidazole-15N2

Imidazole- ¹⁵N₂ (Glyoxaline- ¹⁵N₂) is ¹⁵N labeled Imidazole. Imidazole (Glyoxaline; 1,3-Diaza-2,4-cyclopentadiene) is a heterocyclic aromatic compound. Imidazole bearing molecules have been used as corrosion, acetylcholinesterase (AChEI) and xanthine oxidase (XO) inhibitors, performing biological activities such as antifungal, antituberculosis, anti-inflammatory, antioxidant, and analgesic, amongst many others. Imidazole inhibits the enzymatic conversion of the endoperoxides (PGG₂ and PGH₂) to thromboxane A2 by platelet microsomes. Imidazole derivatives exhibits inhibition on SARS-CoV-2 3CL ^Pro enzyme, which is promising for research in the field of Alzheimer’s disease, gout, COVID-19 and thrombo-embolic disease .

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