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tricyclic antidepressant

" in MedChemExpress (MCE) Product Catalog:

59

Inhibitors & Agonists

1

Natural
Products

16

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-142122
    Imipramine N-oxide

    		Drug Metabolite Neurological Disease
    Imipramine N-oxide is the metabolite of Imipramine. Imipramine is a tertiary amine tricyclic antidepressant .
    Imipramine N-oxide
  • HY-100046
    Nordoxepin hydrochloride

    Desmethyldoxepin hydrochloride

    		 Drug Metabolite Neurological Disease
    Nordoxepin hydrochloride is the major metabolite of Doxepin. Doxepin is a tricyclic antidepressant that is widely prescribed for the research of mild depression .
    Nordoxepin hydrochloride
  • HY-B1417
    Nortriptyline hydrochloride
    2 Publications Verification

    Desmethylamitriptyline hydrochloride; Desitriptilina hydrochloride

    		 Autophagy Drug Metabolite Apoptosis Neurological Disease Cancer
    Nortriptyline (Desmethylamitriptyline) hydrochloride, the main active metabolite of Amitriptyline, is a tricyclic antidepressant. Nortriptyline hydrochloride is a potent autophagy inhibitor and has anticancer effects .
    Nortriptyline hydrochloride
  • HY-118620
    Nortriptyline
    2 Publications Verification

    Desmethylamitriptyline; Desitriptilina

    		 Autophagy Drug Metabolite Apoptosis Neurological Disease Cancer
    Nortriptyline (Desmethylamitriptyline), the main active metabolite of Amitriptyline, is a tricyclic antidepressant. Nortriptyline is a potent autophagy inhibitor and has anticancer effects . N
    Nortriptyline
  • HY-12388A
    N-Desmethyl clomipramine hydrochloride

    Desmethylclomipramine hydrochloride; Norclomipramine hydrochloride

    		 Drug Metabolite Neurological Disease
    N-Desmethyl Clomipramine hydrochloride (Desmethylclomipramine hydrochloride) is a primary plasma N-desmethyl metabolite of Clomipramine. Clomipramine is a tricyclic antidepressant .
    N-Desmethyl clomipramine hydrochloride
  • HY-B0725S
    Doxepin D3 Hydrochloride

    		Histamine Receptor Cytochrome P450 Neurological Disease
    Doxepin-d3 (hydrochloride) is a deuterium labeled Doxepin Hydrochloride. Doxepin hydrochloride is an orally active tricyclic antidepressant. Doxepin hydrochloride is a potent and selective histamine receptor H1 antagonist. Doxepin hydrochloride is also a potent CYP450 inhibitor and significantly inhibits CYP450 2C19 and 1A2[1][2].
    Doxepin D3 Hydrochloride
  • HY-B1417R
    Nortriptyline hydrochloride (Standard)

    		Autophagy Drug Metabolite Apoptosis Neurological Disease Cancer
    Nortriptyline (hydrochloride) (Standard) is the analytical standard of Nortriptyline (hydrochloride). This product is intended for research and analytical applications. Nortriptyline (Desmethylamitriptyline) hydrochloride, the main active metabolite of Amitriptyline, is a tricyclic antidepressant. Nortriptyline hydrochloride is a potent autophagy inhibitor and has anticancer effects .
    Nortriptyline hydrochloride (Standard)
  • HY-100046R
    Nordoxepin hydrochloride (Standard)

    		Drug Metabolite Neurological Disease
    Nordoxepin (hydrochloride) (Standard) is the analytical standard of Nordoxepin (hydrochloride). This product is intended for research and analytical applications. Nordoxepin hydrochloride is the major metabolite of Doxepin. Doxepin is a tricyclic antidepressant that is widely prescribed for the research of mild depression .
    Nordoxepin hydrochloride (Standard)
  • HY-121778
    Melitracen

    Melitracene; N 7001; Trausabun

    		 Others Neurological Disease
    Melitracen (Melitracene) is an orally active tricyclic antidepressant and it is also a bipolar thymoleptic with activating properties. Melitracen inhibits 3H-5-HT and 14H-5-HT with IC50s of 670 nM and 5500 nM, respectively. Melitracen can be used for the research of depression and anxiety .
    Melitracen
  • HY-A0175
    Butriptyline

    Butriptylene

    		 Others Neurological Disease
    Butriptyline (Butriptylene) is an orally active tricyclic antidepressant agent .
    Butriptyline
  • HY-B0949
    Protriptyline hydrochloride
    3 Publications Verification

    		 Cholinesterase (ChE) Neurological Disease
    Protriptyline hydrochloride is a tricyclic antidepressant (TCA), specifically a secondary amine, for the treatment of depression and ADHD.
    Protriptyline hydrochloride
  • HY-106079
    Fezolamine

    		Others Neurological Disease
    Fezolamine is an orally active non-tricyclic compound , and shows antidepressant activity .
    Fezolamine
  • HY-101684
    Nitroxazepine

    CIBA 2330Go

    		 Serotonin Transporter Neurological Disease
    Nitroxazepine is a tricyclic antidepressant (TCA) for the research of depression. Nitroxazepine acts as a serotonin-norepinephrine reuptake inhibitor.
    Nitroxazepine
  • HY-12392
    Iprindole

    		5-HT Receptor Neurological Disease Metabolic Disease
    Iprindole, a tricyclic indole antidepressant, is a weak inhibitor of the uptake of noradrenaline and 5-HT .
    Iprindole
  • HY-101684A
    Nitroxazepine hydrochloride

    CIBA 2330Go hydrochloride

    		 Serotonin Transporter Neurological Disease
    Nitroxazepine hydrochloride is a tricyclic antidepressant (TCA) for the treatment of depression. Nitroxazepine acts as a serotonin-norepinephrine reuptake inhibitor.
    Nitroxazepine hydrochloride
  • HY-133771AS
    Nordoxepin-d3 hydrochloride

    Desmethyldoxepin-d3 (hydrochloride)

    		 Drug Metabolite Neurological Disease
    Nordoxepin-d3 (hydrochloride) is the deuterium labeled Nordoxepin hydrochloride. Nordoxepin hydrochloride is an active metabolite of Doxepin hydrochloride (HY-B0725), which is an orally active tricyclic antidepressant[1].
    Nordoxepin-d3 hydrochloride
  • HY-100651
    Desmethylnortriptyline

    		Drug Metabolite Neurological Disease
    Desmethylnortriptyline is a metabolite of Nortriptyline. Nortriptyline is a tricyclic antidepressant and the main active metabolite of Amitriptyline, and is used to relieve the symptoms of depression .
    Desmethylnortriptyline
  • HY-121203A
    Citalopram oxalate

    		Others Neurological Disease
    Citalopram oxalate is a serotonin uptake inhibitor that serves as an antidepressant, effectively reducing ethanol uptake in alcoholics and offering a preferable option for depressed patients experiencing tardive dyskinesia compared to tricyclic antidepressants, which may worsen this condition.
    Citalopram oxalate
  • HY-100646
    (E)-10-Hydroxynortriptyline maleate

    		Drug Metabolite Neurological Disease
    (E)-10-Hydroxynortriptyline maleate is a metabolite of Nortriptyline. Nortriptyline is a tricyclic antidepressant and the main active metabolite of Amitriptyline, and is used to relieve the symptoms of depression .
    (E)-10-Hydroxynortriptyline maleate
  • HY-100646A
    (Z)-10-Hydroxynortriptyline

    		Drug Metabolite Neurological Disease
    (Z)-10-Hydroxynortriptyline is a metabolite of Nortriptyline. Nortriptyline is a tricyclic antidepressant and the main active metabolite of Amitriptyline, and is used to relieve the symptoms of depression .
    (Z)-10-Hydroxynortriptyline
  • HY-106456
    Depramine

    GP 31406

    		 Cholinesterase (ChE) Neurological Disease
    Depramine (GP 31406) is a tricyclic antidepressant with pharmacologically activity. Depramine inhibits acetylcholinesterase，Mg 2+-ATPase，and Na+/K+ ATPase activity .
    Depramine
  • HY-12390
    Lofepramine

    Lopramine

    		 Others Neurological Disease
    Lofepramine (Lopramine) is a potent tricyclic antidepressant and is extensively metabolised to Desipramine. The antidepressant activity of Lofepramine stems from the facilitation of noradrenergic neurotransmission by uptake inhibition. Lofepramine may also potentiate serotoninergic neurotransmission by inhibition of the neuronal uptake of serotonin and the enzyme tryptophan pyrrolase. Lofepramine has significant anxiolytic efficacy in addition to its antidepressant properties .
    Lofepramine
  • HY-12390A
    Lofepramine hydrochloride

    Lopramine hydrochloride

    		 Others Neurological Disease
    Lofepramine (Lopramine) hydrochloride is a potent tricyclic antidepressant and is extensively metabolised to Desipramine. The antidepressant activity of Lofepramine hydrochloride stems from the facilitation of noradrenergic neurotransmission by uptake inhibition. Lofepramine hydrochloride may also potentiate serotoninergic neurotransmission by inhibition of the neuronal uptake of serotonin and the enzyme tryptophan pyrrolase. Lofepramine hydrochloride has significant anxiolytic efficacy in addition to its antidepressant properties .
    Lofepramine hydrochloride
  • HY-B1417S
    Nortriptyline-d3 hydrochloride

    Desmethylamitriptyline-d3 (hydrochloride); Desitriptilina-d3 (hydrochloride)

    		 Autophagy Apoptosis Drug Metabolite Neurological Disease Cancer
    Nortriptyline-d3 (hydrochloride) is the deuterium labeled Nortriptyline hydrochloride. Nortriptyline hydrochloride (Desmethylamitriptyline hydrochloride) is a tricyclic antidepressant and the main active metabolite of Amitriptyline, and used to relieve the symptoms of depression[1].
    Nortriptyline-d3 hydrochloride
  • HY-101753
    Cianopramine

    Cyanimipramine; Ro 11-2465

    		 5-HT Receptor Neurological Disease
    Cianopramine (Cyanimipramine) is a tricyclic antidepressant, and a potent inhibitor of neuronal serotonin (5-HT) uptake. Cianopramine blocks central and peripheral 5-HT receptors .
    Cianopramine
  • HY-B0457
    Clomipramine hydrochloride
    2 Publications Verification

    Chlorimipramine hydrochloride; G-34586 hydrochloride; NSC-169865 hydrochloride

    		 Serotonin Transporter Neurological Disease
    Clomipramine (Chlorimipramine) hydrochloride is a potent 5-HT reuptake blocker with the IC50 value of 1.5 nM. Clomipramine hydrochloride is a tricyclic antidepressant that can be used for the research of depression and obsessive compulsive disorder (OCD) .
    Clomipramine hydrochloride
  • HY-B0457A
    Clomipramine
    2 Publications Verification

    Chlorimipramine; G-34586; NSC-169865

    		 Serotonin Transporter Neurological Disease
    Clomipramine (Chlorimipramine) is a potent 5-HT reuptake blocker with the IC50 value of 1.5 nM. Clomipramine is a tricyclic antidepressant that can be used for the research of depression and obsessive compulsive disorder (OCD) .
    Clomipramine
  • HY-B0725
    Doxepin Hydrochloride
    4 Publications Verification

    		 Histamine Receptor Cytochrome P450 Neurological Disease Cancer
    Doxepin hydrochloride is an orally active tricyclic antidepressant agent. Doxepin hydrochloride is a potent and selective histamine receptor H1 antagonist. Doxepin hydrochloride is also a potent CYP450 inhibitor and significantly inhibits CYP450 2C19 and 1A2 . Doxepin inhibits reuptake of serotonin and norepinephrine as a tricyclic antidepressant .
    . Doxepin has therapeutic effects in atopic dermatitis，chronic urticarial，can improve cognitive processes， protect central nervous system .
    . Doxepin has also been proposed as a protective factor against oxidative stress .
    .
    Doxepin Hydrochloride
  • HY-12390S
    Lofepramine-d3

    		Isotope-Labeled Compounds Neurological Disease
    Lofepramine-d3 (Lopramine-d3) is the deuterium labeled Lofepramine. Lofepramine (Lopramine) is a potent tricyclic antidepressant and is extensively metabolised to Desipramine. The antidepressant activity of Lofepramine stems from the facilitation of noradrenergic neurotransmission by uptake inhibition. Lofepramine may also potentiate serotoninergic neurotransmission by inhibition of the neuronal uptake of serotonin and the enzyme tryptophan pyrrolase. Lofepramine has significant anxiolytic efficacy in addition to its antidepressant properties[1].
    Lofepramine-d3
  • HY-B1272A
    Desipramine

    		Adrenergic Receptor Neurological Disease
    Desipramine is a tricyclic psychotic compound, possessing antidepressant activity. Desipramine inhibits the norepinephrine reuptake receptor in the central nervous system and reduces the sleep-related loss of genioglossus activity, can be used to research the improvement of pharyngeal collapsibility .
    Desipramine
  • HY-12388AR
    N-Desmethyl clomipramine hydrochloride (Standard)

    Desmethylclomipramine hydrochloride (Standard); Norclomipramine hydrochloride (Standard)

    		 Drug Metabolite Neurological Disease
    N-Desmethyl Clomipramine (hydrochloride) (Standard) is the analytical standard of N-Desmethyl Clomipramine (hydrochloride). This product is intended for research and analytical applications. N-Desmethyl Clomipramine hydrochloride (Desmethylclomipramine hydrochloride) is a primary plasma N-desmethyl metabolite of Clomipramine. Clomipramine is a tricyclic antidepressant .
    N-Desmethyl clomipramine hydrochloride (Standard)
  • HY-118901
    Opipramol

    Ensidon; G-33040

    		 Sigma Receptor Neurological Disease
    Opipramol (Ensidon) is an atypical tricyclic antidepressant (TCA). Opipramol acts primarily as a sigma (σ) receptor agonist and can potently interact with sigma recognition sites with a Ki value of 50 nM. Opipramol can be used for the research of generalized anxiety disorder (GAD) .
    Opipramol
  • HY-B0725R
    Doxepin Hydrochloride (Standard)

    		Histamine Receptor Cytochrome P450 Neurological Disease Cancer
    Doxepin (Hydrochloride) (Standard) is the analytical standard of Doxepin (Hydrochloride). This product is intended for research and analytical applications. Doxepin hydrochloride is an orally active tricyclic antidepressant agent. Doxepin hydrochloride is a potent and selective histamine receptor H1 antagonist. Doxepin hydrochloride is also a potent CYP450 inhibitor and significantly inhibits CYP450 2C19 and 1A2 . Doxepin inhibits reuptake of serotonin and norepinephrine as a tricyclic antidepressant .
    . Doxepin has therapeutic effects in atopic dermatitis，chronic urticarial，can improve cognitive processes， protect central nervous system .
    . Doxepin has also been proposed as a protective factor against oxidative stress .
    .
    Doxepin Hydrochloride (Standard)
  • HY-B0457S1
    Clomipramine-d6 hydrochloride

    Chlorimipramine-d6 (hydrochloride); G-34586-d6 (hydrochloride); NSC-169865-d6 (hydrochloride)

    		 Serotonin Transporter Neurological Disease
    Clomipramine-d6 (hydrochloride) is the deuterium labeled Clomipramine hydrochloride. Clomipramine (Chlorimipramine) hydrochloride is a potent 5-HT reuptake blocker with the IC50 value of 1.5 nM. Clomipramine hydrochloride is a tricyclic antidepressant that can be used for the research of depression and obsessive compulsive disorder (OCD)[1].
    Clomipramine-d6 hydrochloride
  • HY-B0457AR
    Clomipramine (Standard)

    		Serotonin Transporter Neurological Disease
    Clomipramine (Standard) is the analytical standard of Clomipramine. This product is intended for research and analytical applications. Clomipramine (Chlorimipramine) is a potent 5-HT reuptake blocker with the IC50 value of 1.5 nM. Clomipramine is a tricyclic antidepressant that can be used for the research of depression and obsessive compulsive disorder (OCD) .
    Clomipramine (Standard)
  • HY-B0457R
    Clomipramine hydrochloride (Standard)

    		Serotonin Transporter Neurological Disease
    Clomipramine (hydrochloride) (Standard) is the analytical standard of Clomipramine (hydrochloride). This product is intended for research and analytical applications. Clomipramine (Chlorimipramine) hydrochloride is a potent 5-HT reuptake blocker with the IC50 value of 1.5 nM. Clomipramine hydrochloride is a tricyclic antidepressant that can be used for the research of depression and obsessive compulsive disorder (OCD) .
    Clomipramine hydrochloride (Standard)
  • HY-B0949S
    Protriptyline (N-methyl-d3) (hydrochloride)

    		Cholinesterase (ChE) Neurological Disease
    Protriptyline (N-methyl-d3) (hydrochloride) is the deuterium labeled Protriptyline hydrochloride. Protriptyline hydrochloride is a tricyclic antidepressant (TCA), specifically a secondary amine, for the treatment of depression and ADHD. Unique among the TCAs, protriptyline tends to be energizing instead of sedating, used for narcolepsy to achieve a wakefulness-promoting effect[1].
    Protriptyline (N-methyl-d3) (hydrochloride)
  • HY-107031
    Metapramine

    19560 RP

    		 iGluR Others
    Metapramine (19560 RP) is an antidepressant agent, belonging to the class of tricyclic compounds . Metapramine inhibits norepinephrine reuptake, without affecting the reuptake of serotonin or dopamine . Metapramine is a low-affinity antagonist of the N-methyl-D-aspartic acid (NMDA) receptor complex channel .
    Metapramine
  • HY-B0725A
    Doxepin

    		mTOR PI3K Akt Neurological Disease
    Doxepin inhibits reuptake of serotonin and norepinephrine as a tricyclic antidepressant. Doxepin has therapeutic effects in atopic dermatitis，chronic urticarial，can improve cognitive processes， protect central nervous system. Doxepin has also been proposed as a protective factor against oxidative stress .
    Doxepin
  • HY-U00050S
    (E)-10-Hydroxynortriptyline-d3

    E-10-OH-NT-d3

    		 Isotope-Labeled Compounds Drug Metabolite Neurological Disease
    (E)-10-Hydroxynortriptyline-d3 is a deuterium labeled (E)-10-Hydroxy Nortriptyline. (E)-10-Hydroxy Nortriptyline is a metabolite of Nortriptyline. Nortriptyline is a tricyclic antidepressant and the main active metabolite of Amitriptyline, and is used to relieve the symptoms of depression[1].
    (E)-10-Hydroxynortriptyline-d3
  • HY-B0457S2
    Clomipramine-13C,d3 hydrochloride

    Chlorimipramine-13C,d3 hydrochloride; G-34586-13C,d3 hydrochloride; NSC-169865-13C,d3 hydrochloride

    		 Isotope-Labeled Compounds Serotonin Transporter Neurological Disease
    Clomipramine- 13C,d3 (hydrochloride) is the 13C- and deuterium labeled Clomipramine (hydrochloride). Clomipramine (Chlorimipramine) hydrochloride is a potent 5-HT reuptake blocker with the IC50 value of 1.5 nM. Clomipramine hydrochloride is a tricyclic antidepressant that can be used for the research of depression and obsessive compulsive disorder (OCD)[1].
    Clomipramine-13C,d3 hydrochloride
  • HY-B1272AS1
    Desipramine-d3

    		Dopamine Transporter Serotonin Transporter Metabolic Disease
    Desipramine-d3 is the deuterium labeled Desipramine. Desipramine is a tricyclic psychotic compound, possessing antidepressant activity. Desipramine inhibits the norepinephrine reuptake receptor in the central nervous system and reduces the sleep-related loss of genioglossus activity, can be used to research the improvement of pharyngeal collapsibility[1][2][3].
    Desipramine-d3
  • HY-12388AS
    N-Desmethyl clomipramine-d3 hydrochloride

    Desmethylclomipramine-d3 (hydrochloride)；Norclomipramine-d3 hydrochloride

    		 Drug Metabolite Neurological Disease
    N-Desmethyl Clomipramine-d3 (hydrochloride) is the deuterium labeled N-Desmethyl Clomipramine. N-Desmethyl Clomipramine hydrochloride (Desmethylclomipramine hydrochloride) is a primary plasma N-desmethyl metabolite of Clomipramine[1]
    N-Desmethyl clomipramine-d3 hydrochloride
  • HY-118901R
    Opipramol (Standard)

    		Sigma Receptor Neurological Disease
    Opipramol (Standard) is the analytical standard of Opipramol. This product is intended for research and analytical applications. Opipramol (Ensidon) is an atypical tricyclic antidepressant (TCA). Opipramol acts primarily as a sigma (σ) receptor agonist and can potently interact with sigma recognition sites with a Ki value of 50 nM. Opipramol can be used for the research of generalized anxiety disorder (GAD) .
    Opipramol (Standard)
  • HY-100646AS
    (Z)-10-Hydroxynortriptyline-d3

    		Drug Metabolite Neurological Disease
    (Z)-10-Hydroxynortriptyline-d3 is the deuterium labeled (Z)-10-Hydroxynortriptyline (HY-100646A). (Z)-10-Hydroxynortriptyline is a metabolite of Nortriptyline (HY-118620). Nortriptyline is a tricyclic antidepressant and the main active metabolite of Amitriptyline, and is used to relieve the symptoms of depression[1][2].
    (Z)-10-Hydroxynortriptyline-d3
  • HY-B1482
    Mesoridazine benzenesulfonate

    TPS-23 benzenesulfonate

    		 Potassium Channel Neurological Disease
    Mesoridazine (TPS-23) benzenesulfonate, a metabolite of Thioridazine (HY-B0965A), acts as an orally active phenothiazine antipsychotic agent. Mesoridazine benzenesulfonate is a potent and rapid open-channel blocker of human ether-a-go-go related gene (hERG) channels and blocks hERG currents with an IC50 of 550 nM (at 0 mV) in human embryonic kidney 293 cells .Mesoridazine benzenesulfonate can be used for the research of schizophrenia, as well as certain other psychiatric disorders .
    Mesoridazine benzenesulfonate
  • HY-B1482A
    Mesoridazine

    TPS-23

    		 Potassium Channel Neurological Disease
    Mesoridazine (TPS-23) , a metabolite of Thioridazine (HY-B0965A), acts as an orally active phenothiazine antipsychotic agent. Mesoridazine is a potent and rapid open-channel blocker of human ether-a-go-go related gene (hERG) channels and blocks hERG currents with an IC50 of 550 nM (at 0 mV) in human embryonic kidney 293 cells .Mesoridazine can be used for the research of schizophrenia, as well as certain other psychiatric disorders .
    Mesoridazine
  • HY-B1490
    Imipramine hydrochloride
    5 Publications Verification

    		 Serotonin Transporter Apoptosis Autophagy Neurological Disease Inflammation/Immunology Cancer
    Imipramine hydrochloride is an orally active tertiary amine tricyclic antidepressant. Imipramine hydrochloride is a Fascin1 inhibitor with antitumor activities. Imipramine hydrochloride also inhibits serotonin transporter with an IC50 value of 32 nM. Imipramine hydrochloride stimulates U-87MG glioma cells autophagy and induces HL-60 cell apoptosis. Imipramine hydrochloride shows neuroprotective and immunomodulatory effects .
    Imipramine hydrochloride
  • HY-B1490A
    Imipramine
    5 Publications Verification

    		 Serotonin Transporter Autophagy Apoptosis Neurological Disease Inflammation/Immunology Cancer
    Imipramine is an orally active tertiary amine tricyclic antidepressant. Imipramine is a Fascin1 inhibitor with antitumor activities. Imipramine also inhibits serotonin transporter with an IC50 value of 32 nM. Imipramine stimulates U-87MG glioma cells autophagy and induces HL-60 cell apoptosis. Imipramine shows neuroprotective and immunomodulatory effects .
    Imipramine
  • HY-U00050
    (E)-10-Hydroxynortriptyline

    E-10-OH-NT

    		 Drug Metabolite Neurological Disease
    (E)-10-Hydroxynortriptyline (E-10-OH-NT) is a metabolite of Nortriptyline (HY-B1417). Nortriptyline is a tricyclic antidepressant and the main active metabolite of Amitriptyline (HY-B0527A) . E-10-OH-NT is about 50% as potent as nortriptyline as an inhibitor of the neuronal uptake of norepinephrine in vitro and exhibits less anticholinergic effects in man.
    (E)-10-Hydroxynortriptyline

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