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ALV2 is a potent and selective Helios degrader. ALV2 binds CRBN, with an IC50 of 0.57 μM. Helios is the zinc-finger transcription factor that can maintain a stable Treg cell phenotype in the inflammatory tumor microenvironment .
Cemsidomide (CFT7455) is an orally active zinc finger transcription factors Ikaros (IKZF1), Aiolos (IKZF3) degrader. Cemsidomide is an anti-cancer agent that binds with high affinity to the cereblon E3 ligase (Kd of 0.9 nM) (WO2022032132A1; Compound 1) .
Glaucocalyxin A, an ent-kauranoid diterpene from Rabdosia japonica var., induces apoptosis in osteosarcoma by inhibiting nuclear translocation of Five-zinc finger Glis 1 (GLI1) via regulating PI3K/Akt signaling pathway. Glaucocalyxin A has antitumor effect .
FPFT-2216, a “molecular glue” compound, degrades phosphodiesterase 6D (PDE6D), zinc finger transcription factors Ikaros (IKZF1), Aiolos (IKZF3), and casein kinase 1α (CK1α). FPFT-2216 can be used for the research of cancer and inflammatory disease .
CC-3060 is a Cereblon modulator that promotes ZBTB16 degradation. CC-3060 degrades ZBTB16 with a DC50 of 0.47 nM in HT-1080 cells. CC-3060 targets ZBTB16 for degradation by primarily engaging distinct structural degrons on different zinc finger domains .
YPC-22026 is a zinc-finger protein 143 (ZNF143) inhibitor with an IC50 value of 9.0 μM. YPC-22026 is a potent tumor regression inducer. YPC-22026 exhibits anti‐tumor activities .
WIZ degrader 1 (Compound 141) is a degrader for widely interspaced zinc finger motifs (WIZ) with an AC50 of 2 nM. WIZ degrader 1 induces the expression of fetal hemoglobin (HbF) with an EC50 of 6 mM. WIZ degrader 1 is used in research of inherited blood disorders .
WIZ degrader 2 (Compound 142) is a degrader for widely interspaced zinc finger motifs with an AC50 of 0.011 μM. WIZ degrader 2 induces the expression of fetal hemoglobin (HbF) with an EC50 of 0.038 μM. WIZ degrader 2 can be used in research about inherited blood disorders .
WIZ degrader 3 (Compound 29) is a degrader for widely interspaced zinc finger motifs (WIZ), with an AC50 of 6.4 nM. WIZ degrader 3 induces the expression of fetal hemoglobin (HbF), with an EC50 of 45 nM. WIZ degrader 3 can be used for the research of blood disorders, such as sickle cell disease and β- thalassemia .
Naringin is a major flavanone glycoside obtained from tomatoes, grapefruits, and many other citrus fruits. Naringin exhibits biological properties such as antioxidant, anti-inflammatory, and antiapoptotic activities. Naringin also inhibits proliferation and invasion and induces apoptosis in human osteosarcoma cells by inhibiting zinc finger E-box binding homeobox 1 (Zeb1) .
Naringin is a major flavanone glycoside obtained from tomatoes, grapefruits, and many other citrus fruits. Naringin exhibits biological properties such as antioxidant, anti-inflammatory, and antiapoptotic activities. Naringin also inhibits proliferation and invasion and induces apoptosis in human osteosarcoma cells by inhibiting zinc finger E-box binding homeobox 1 (Zeb1) .
ZNF207-IN-1 (compound C16) is a potent inhibitor of Zinc Finger Protein 207 (ZNF207)， with IC50 values ranging from 0.5–2.5 μM for inhibiting sphere formation and 0.5–15 μM for cytotoxicity. ZNF207-IN-1 exhibites efficient permeability across the blood–brain barrier .
JWJ-01-306 is a molecular glue that targets the C2H2zinc finger transcription factor ZBTB11. JWJ-01-306 degrades ZBTB11, reduces the oxidative phosphorylation (OXPHOS) and tricarboxylic acid (TCA) cycle, and inhibits the proliferation of KAS-resistant PDAC cells. JWJ-01-306 exhibits good pharmacokinetic characteristics in mouse model .
(Rac)-Cemsidomide ((Rac)-CFT7455) is a zinc finger transcription factors Ikaros (IKZF1) and Aiolos (IKZF3) degrader, acting via the ubiquitin proteasome pathway, with a GI50 of 0.05 nM for NCIH929.1 cells. (Rac)-Cemsidomide is the racemic isomer of Cemsidomide (HY-144841A) which is a IKZF1/IKZF3 degrader with anticancer activity .
PT-179 is an orthogonal Thalidomide (HY-14658) derivative that targets cereblon without causing off-target degradation effects. PT-179 is able to specifically bind CRBN, form a ternary complex with a target protein fused to a zinc finger (ZF) degron, and mediate the degradation of the tagged protein. For example, PT-179 binds to the ubiquitin ligase substrate receptor cereblon by forming a complex with SD40 and efficiently degrades proteins N- or C-terminally fused to SD40 or SD36 (DC50 for eGFP: 4.5 nM and 14.3 nM). PT-179 can be used to develop compact protein degradation tagging platforms .
Glaucocalyxin A, an ent-kauranoid diterpene from Rabdosia japonica var., induces apoptosis in osteosarcoma by inhibiting nuclear translocation of Five-zinc finger Glis 1 (GLI1) via regulating PI3K/Akt signaling pathway. Glaucocalyxin A has antitumor effect .
Naringin is a major flavanone glycoside obtained from tomatoes, grapefruits, and many other citrus fruits. Naringin exhibits biological properties such as antioxidant, anti-inflammatory, and antiapoptotic activities. Naringin also inhibits proliferation and invasion and induces apoptosis in human osteosarcoma cells by inhibiting zinc finger E-box binding homeobox 1 (Zeb1) .
Naringin is a major flavanone glycoside obtained from tomatoes, grapefruits, and many other citrus fruits. Naringin exhibits biological properties such as antioxidant, anti-inflammatory, and antiapoptotic activities. Naringin also inhibits proliferation and invasion and induces apoptosis in human osteosarcoma cells by inhibiting zinc finger E-box binding homeobox 1 (Zeb1) .
zincfinger and BTB Domain-Containing Protein 17; Myc-Interacting zincfinger Protein 1; Miz-1; zincfinger Protein 151; zincfinger Protein 60; ZBTB17; MIZ1; ZNF151; ZNF60
The ZBTB17 protein is a multifunctional transcription factor that functions as a binding partner-based activator or repressor and a targeted regulator of cell cycle progression. It is essential for early lymphocyte development, preventing apoptosis and ensuring lineage commitment. ZBTB17 Protein, Human (His) is the recombinant human-derived ZBTB17 protein, expressed by E. coli , with N-6*His labeled tag. The total length of ZBTB17 Protein, Human (His) is 188 a.a., with molecular weight of ~18.0-26.0 kDa.
ZBTB7B; zincfinger and BTB domain-containing protein 7B; Krueppel-related zincfinger protein cKrox; hcKrox; T-helper-inducing POZ/Krueppel-like factor; zincfinger and BTB domain-containing protein 15; zincfinger protein 67 homolog; Zfp-67; zincfinger protein 857B; zincfinger protein Th-POK
The ZBTB7B protein is a transcriptional regulator that determines the lineage commitment of T cell precursors, which is critical for the fate of CD4 and CD8 cells. Essential for CD4 commitment, its absence results in CD8 commitment. ZBTB7B Protein, Human (Sf9) is the recombinant human-derived ZBTB7B protein, expressed by Sf9 insect cells , with tag free. The total length of ZBTB7B Protein, Human (Sf9) is 538 a.a., .
ZBTB7B; zincfinger and BTB domain-containing protein 7B; Krueppel-related zincfinger protein cKrox; hcKrox; T-helper-inducing POZ/Krueppel-like factor; zincfinger and BTB domain-containing protein 15; zincfinger protein 67 homolog; Zfp-67; zincfinger protein 857B; zincfinger protein Th-POK
The ZBTB7B protein is a transcriptional regulator that determines the lineage commitment of T cell precursors, which is critical for the fate of CD4 and CD8 cells. Essential for CD4 commitment, its absence results in CD8 commitment. ZBTB7B Protein, Human (Sf9, His, Strep) is the recombinant human-derived ZBTB7B protein, expressed by Sf9 insect cells , with N-Strep, N-8*His labeled tag. The total length of ZBTB7B Protein, Human (Sf9, His, Strep) is 538 a.a., .
GZF1, a transcriptional repressor, regulates gene expression by binding to the GZF1 responsive element (GRE) with the consensus sequence 5'-TGCGCN[TG][CA]TATA-3'. Its role includes potential regulation of VSX2/HOX10 expression, and it interacts with NCL, suggesting a molecular association that contributes to its transcriptional modulatory activities. GZF1 Protein, Human (Sf9) is the recombinant human-derived GZF1 protein, expressed by Sf9 insect cells , with tag free. The total length of GZF1 Protein, Human (Sf9) is 710 a.a., .
ZMYND19 Protein, implicated in GPR24/MCH-R1 signaling, suggests a role in modulating the associated pathways. Its interaction with GPR24/MCH-R1 indicates regulatory involvement. Mechanisms and downstream effects of ZMYND19 in GPR24/MCH-R1 signaling require further elucidation. Exploring ZMYND19's functions may provide insights into its role in cellular responses, offering potential interventions in G protein-coupled receptor pathways. ZMYND19 Protein, Human (His) is the recombinant human-derived ZMYND19 protein, expressed by E. coli , with N-6*His labeled tag. The total length of ZMYND19 Protein, Human (His) is 227 a.a., with molecular weight of ~32.0 kDa.
The ZFAND5 protein is a key player in protein degradation by the ubiquitin-proteasome system and serves as a potential anchor for ubiquitinated proteins, promoting their proteasomal targeting. It regulates NF-kappa-B activation and apoptosis by inhibiting NF-kappa-B activation induced by various stimuli, including RIPK1 and TRAF6 overexpression. ZFAND5 Protein, Human (Sf9) is the recombinant human-derived ZFAND5 protein, expressed by Sf9 insect cells , with tag free. The total length of ZFAND5 Protein, Human (Sf9) is 212 a.a., .
The ZNF70 protein itself is a potential regulator of transcriptional processes, suggesting that it may play a role in shaping cellular function through gene expression control. Although the specific mechanisms and target genes affected by ZNF70 are not fully understood, its versatility in transcriptional regulation implies potential effects on a variety of cellular pathways. ZNF70 Protein, Human (His) is the recombinant human-derived ZNF70 protein, expressed by E. coli , with N-6*His labeled tag. The total length of ZNF70 Protein, Human (His) is 446 a.a., with molecular weight of ~60.0 kDa.
GZF1, a transcriptional repressor, regulates gene expression by binding to the GZF1 responsive element (GRE) with the consensus sequence 5'-TGCGCN[TG][CA]TATA-3'. Its role includes potential regulation of VSX2/HOX10 expression, and it interacts with NCL, suggesting a molecular association that contributes to its transcriptional modulatory activities. GZF1 Protein, Human (Sf9, His, Strep) is the recombinant human-derived GZF1 protein, expressed by Sf9 insect cells , with N-Strep, N-8*His labeled tag. The total length of GZF1 Protein, Human (Sf9, His, Strep) is 710 a.a., .
The ZFAND5 protein is a key player in protein degradation by the ubiquitin-proteasome system and serves as a potential anchor for ubiquitinated proteins, promoting their proteasomal targeting. It regulates NF-kappa-B activation and apoptosis by inhibiting NF-kappa-B activation induced by various stimuli, including RIPK1 and TRAF6 overexpression. ZFAND5 Protein, Human (Sf9, His, Strep) is the recombinant human-derived ZFAND5 protein, expressed by Sf9 insect cells , with N-Strep, N-8*His labeled tag. The total length of ZFAND5 Protein, Human (Sf9, His, Strep) is 212 a.a., .
RIZ1 Protein, an S-adenosyl-L-methionine-dependent histone methyltransferase, specifically methylates 'Lys-9' of histone H3. Additionally, it acts as a DNA-binding transcription factor, showing affinity for the MTE within the HMOX1 gene. Implicated as a potential activator, RIZ1 suggests a regulatory role in HMOX1 gene expression beyond histone modification. RIZ1 Protein, Human is the recombinant human-derived RIZ1 protein, expressed by E. coli , with tag free. The total length of RIZ1 Protein, Human is 200 a.a., with molecular weight of ~26 kDa.
RIZ1 Protein, an S-adenosyl-L-methionine-dependent histone methyltransferase, specifically methylates 'Lys-9' of histone H3. Additionally, it acts as a DNA-binding transcription factor, showing affinity for the MTE within the HMOX1 gene. Implicated as a potential activator, RIZ1 suggests a regulatory role in HMOX1 gene expression beyond histone modification. RIZ1 Protein, Human (GST) is the recombinant human-derived RIZ1 protein, expressed by E. coli , with N-GST labeled tag. The total length of RIZ1 Protein, Human (GST) is 200 a.a., with molecular weight of ~49.6 kDa.
RIZ1 Protein, an S-adenosyl-L-methionine-dependent histone methyltransferase, specifically methylates 'Lys-9' of histone H3. Additionally, it acts as a DNA-binding transcription factor, showing affinity for the MTE within the HMOX1 gene. Implicated as a potential activator, RIZ1 suggests a regulatory role in HMOX1 gene expression beyond histone modification. RIZ1 Protein, Human (His) is the recombinant human-derived RIZ1 protein, expressed by E. coli , with N-6*His labeled tag. The total length of RIZ1 Protein, Human (His) is 200 a.a., with molecular weight of ~27 kDa.
OTUD7B; OTU domain-containing protein 7B; Cellular zincfinger anti-NF-kappa-B protein; Cezanne; zincfinger A20 domain-containing protein 1; zincfinger protein Cezanne
The OTUD7B protein acts as a negative regulator to inhibit the non-canonical NF-kappa-B pathway by deubiquitinating TRAF3, thereby inhibiting B cell responses. It prevents degradation of “Lys-48”-linked polyubiquitin chains on TRAF3 during atypical NF-kappa-B stimulation, avoiding overactivation of the pathway and affecting mucosal immunity. OTUD7B Protein, Human (Sf9) is the recombinant human-derived OTUD7B protein, expressed by Sf9 insect cells , with tag free. The total length of OTUD7B Protein, Human (Sf9) is 842 a.a., .
OTUD7B; OTU domain-containing protein 7B; Cellular zincfinger anti-NF-kappa-B protein; Cezanne; zincfinger A20 domain-containing protein 1; zincfinger protein Cezanne
The OTUD7B protein acts as a negative regulator to inhibit the non-canonical NF-kappa-B pathway by deubiquitinating TRAF3, thereby inhibiting B cell responses. It prevents degradation of “Lys-48”-linked polyubiquitin chains on TRAF3 during atypical NF-kappa-B stimulation, avoiding overactivation of the pathway and affecting mucosal immunity. OTUD7B Protein, Human (Sf9, His, Strep) is the recombinant human-derived OTUD7B protein, expressed by Sf9 insect cells , with N-Strep, N-8*His labeled tag. The total length of OTUD7B Protein, Human (Sf9, His, Strep) is 842 a.a., .
The ZNF100 protein emerged as a potential regulator of transcriptional processes, suggesting that it may influence cellular function through gene expression control. Although the specific mechanisms and target genes are not fully understood, the multifunctional nature of ZNF100 in the field of transcriptional regulation suggests its potential impact on various cellular pathways. ZNF100 Protein, Human (His) is the recombinant human-derived ZNF100 protein, expressed by E. coli , with N-6*His labeled tag. The total length of ZNF100 Protein, Human (His) is 108 a.a., with molecular weight of ~15.0 kDa.
The ZNF75A protein appears to be a potential influencer of transcriptional regulation, suggesting that it may play a role in shaping cellular function through gene expression control. Although the specific mechanisms and target genes affected by ZNF75A are not fully understood, its multifunctional nature in transcriptional regulation implies potential effects on a variety of cellular pathways. ZNF75A Protein, Human (His) is the recombinant human-derived ZNF75A protein, expressed by E. coli , with N-6*His labeled tag. The total length of ZNF75A Protein, Human (His) is 105 a.a., with molecular weight of ~14.0 kDa.
ZBTB9 Protein appears as a potential regulator in transcriptional processes, implying a role in modulating cellular functions through gene expression regulation. While specific targets and mechanisms are yet to be fully understood, ZBTB9's versatile nature suggests its potential impact on diverse cellular pathways. This makes ZBTB9 an intriguing candidate for further exploration in the realm of gene regulation and cellular homeostasis. ZBTB9 Protein, Human (His) is the recombinant human-derived ZBTB9 protein, expressed by E. coli , with C-6*His labeled tag. The total length of ZBTB9 Protein, Human (His) is 473 a.a., with molecular weight of ~60.0 kDa.
HKR3 Protein, Human (His, Strep) is the recombinant human-derived HKR3, expressed by E. coli , with Strep, His labeled tag. The total length of HKR3 Protein, Human (His, Strep) is 119 a.a.,
KIAA0136; Microrchidia 3; MORC family CW type zincfinger 3; MORC family CW type zincfinger protein 3; MORC family CW-type zincfinger protein 3; MORC3; MORC3_HUMAN; Nuclear matrix protein 2; Nuclear matrix protein NXP2; NXP2; ZCW5; ZCWCC3
MORC3 protein is a nuclear matrix protein that forms MORC3-NB through an ATP-dependent mechanism to restrict viruses through IFN response regulation, which is critical for innate immunity.It regulates IFNB1 activation and has secondary IFN inhibitory functions.MORC3 Protein, Human (His-SUMO) is the recombinant human-derived MORC3 protein, expressed by E.coli , with N-His, N-SUMO labeled tag.
RNF114; E3 ubiquitin-protein ligase RNF114; RING finger protein 114; RING-type E3 ubiquitin transferase RNF114; zincfinger protein 228; zincfinger protein 313
The RNF114 protein is an E3 ubiquitin protein ligase that critically regulates a variety of cellular processes by ubiquitinating various substrates. RNF114 is involved in cell cycle progression, apoptosis, osteoclastogenesis and immunity, serving as a negative regulator of NF-kappa-B-dependent transcription, affecting immune responses by ubiquitinating TNFAIP3 and potentially TRAF6. RNF114 Protein, Human is the recombinant human-derived RNF114 protein, expressed by E. coli , with tag free. The total length of RNF114 Protein, Human is 227 a.a., .
The RNF141 protein emerged as a potential player in spermatogenesis, suggesting a role in male germ cell development. This implication highlights its importance in the complex regulatory networks that control reproductive biology. RNF141 Protein, Human is the recombinant human-derived RNF141 protein, expressed by E. coli , with tag free. The total length of RNF141 Protein, Human is 229 a.a., .
RNF114; E3 ubiquitin-protein ligase RNF114; RING finger protein 114; RING-type E3 ubiquitin transferase RNF114; zincfinger protein 228; zincfinger protein 313
The RNF114 protein is an E3 ubiquitin protein ligase that critically regulates a variety of cellular processes by ubiquitinating various substrates. RNF114 is involved in cell cycle progression, apoptosis, osteoclastogenesis and immunity, serving as a negative regulator of NF-kappa-B-dependent transcription, affecting immune responses by ubiquitinating TNFAIP3 and potentially TRAF6. RNF114 Protein, Human (GST) is the recombinant human-derived RNF114 protein, expressed by E. coli , with N-GST labeled tag. The total length of RNF114 Protein, Human (GST) is 227 a.a., .
The RNF141 protein emerged as a potential player in spermatogenesis, suggesting a role in male germ cell development. This implication highlights its importance in the complex regulatory networks that control reproductive biology. RNF141 Protein, Human (His) is the recombinant human-derived RNF141 protein, expressed by E. coli , with N-6*His labeled tag. The total length of RNF141 Protein, Human (His) is 229 a.a., .
CTCF protein is a chromatin-binding factor that plays multiple roles in transcriptional regulation and epigenetic control. It binds to DNA at specific sites and acts as a transcriptional repressor by binding to chromatin insulators to prevent undesirable interactions between promoters and neighboring enhancers or silencers. CTCF Protein, Human is the recombinant human-derived CTCF protein, expressed by E. coli , with tag free.
OTUD7A Protein, with deubiquitinating activity, specifically targets 'Lys-11'-linked polyubiquitin chains. OTUD7A Protein, Human (FLAG) is the recombinant human-derived OTUD7A protein, expressed by E. coli , with C-Flag labeled tag. The total length of OTUD7A Protein, Human (FLAG) is 508 a.a., .
The RING finger (RNF) protein contains the RING domain, and exerts E3 ubiquitin ligase that mediates the covalent attachment of ubiquitin to target proteins. RNF113B belongs to the RNF protein family. RNF113B Protein, Human is the recombinant human-derived RNF113B protein, expressed by E. coli , with tag free. The total length of RNF113B Protein, Human is 321 a.a., .
ZFAND3 is a transcriptional regulatory protein that regulates the expression of adhesion and invasion related genes, and can drive the invasion of glioblastoma. In addition, ZFAND3 can improve glucose tolerance by improving insulin resistance and inhibiting gluconeogenesis, and is identified as a susceptibility gene for type 2 diabetes. ZFAND3 Protein, Human (Sf9) is the recombinant human-derived ZFAND3 protein, expressed by Sf9 insect cells , with tag free. The total length of ZFAND3 Protein, Human (Sf9) is 226 a.a., .
The RING finger (RNF) protein contains the RING domain, and exerts E3 ubiquitin ligase that mediates the covalent attachment of ubiquitin to target proteins. RNF113B belongs to the RNF protein family. RNF113B Protein, Human (His) is the recombinant human-derived RNF113B protein, expressed by E. coli , with N-6*His labeled tag. The total length of RNF113B Protein, Human (His) is 321 a.a., .
ZFAND3 is a transcriptional regulatory protein that regulates the expression of adhesion and invasion related genes, and can drive the invasion of glioblastoma. In addition, ZFAND3 can improve glucose tolerance by improving insulin resistance and inhibiting gluconeogenesis, and is identified as a susceptibility gene for type 2 diabetes. ZFAND3 Protein, Human (Sf9, His, Strep) is the recombinant human-derived ZFAND3 protein, expressed by Sf9 insect cells , with N-Strep, N-8*His labeled tag. The total length of ZFAND3 Protein, Human (Sf9, His, Strep) is 226 a.a., .
As an E3-type SUMO ligase, ZBED1 protein catalyzes CHD3/Mi2-α sumoylation, relieves transcriptional repression and promotes the recruitment of RNA polymerase II to gene promoters. This positively regulates H1-5, RPS6, RPL10A and RPL12 transcription, enhancing cell proliferation and growth. ZBED1 Protein, Human (His) is the recombinant human-derived ZBED1 protein, expressed by E. coli , with C-6*His labeled tag. The total length of ZBED1 Protein, Human (His) is 98 a.a., with molecular weight of ~14.0 kDa.
ZRANB1 is a ubiquitin thioesterase that specifically hydrolyzes “Lys-29”-linked and “Lys-33”-linked diubiquitins, with additional activity on “Lys-63”-linked chains. It positively regulates the Wnt pathway by deubiquitinating APC, an inhibitor of Wnt-mediated transcription. ZRANB1 Protein, Human (Sf9) is the recombinant human-derived ZRANB1 protein, expressed by Sf9 insect cells , with tag free. The total length of ZRANB1 Protein, Human (Sf9) is 708 a.a., .
ZRANB1 is a ubiquitin thioesterase that specifically hydrolyzes “Lys-29”-linked and “Lys-33”-linked diubiquitins, with additional activity on “Lys-63”-linked chains. It positively regulates the Wnt pathway by deubiquitinating APC, an inhibitor of Wnt-mediated transcription. ZRANB1 Protein, Human (Sf9, His) is the recombinant human-derived ZRANB1 protein, expressed by Sf9 insect cells , with C-8*His labeled tag. The total length of ZRANB1 Protein, Human (Sf9, His) is 708 a.a., .
RNF113A is an important spliceosome component that participates in pre-mRNA splicing and contributes to U12-type intron splicing within the small spliceosome. As an E3 ubiquitin protein ligase, it catalyzes the transfer of ubiquitin to target proteins. RNF113A Protein, Human is the recombinant human-derived RNF113A protein, expressed by E. coli , with tag free. The total length of RNF113A Protein, Human is 342 a.a., .
TRIM38 Protein: E3 ligase regulating innate immunity. Degrades AZI2/NAP1, suppressing IFN-beta production. Inhibits TLR3 signaling by degrading TICAM1. Activates cGAS-STING pathway via SUMOylation of CGAS and STING. Negatively regulates NF-kappa-B signaling by degrading TAB2 and TAB3 adapters via lysosomes. TRIM38 Protein, Human (GST) is the recombinant human-derived TRIM38 protein, expressed by E. coli , with N-GST labeled tag. The total length of TRIM38 Protein, Human (GST) is 464 a.a., .
RNF113A is an important spliceosome component that participates in pre-mRNA splicing and contributes to U12-type intron splicing within the small spliceosome. As an E3 ubiquitin protein ligase, it catalyzes the transfer of ubiquitin to target proteins. RNF113A Protein, Human (His) is the recombinant human-derived RNF113A protein, expressed by E. coli , with N-6*His labeled tag. The total length of RNF113A Protein, Human (His) is 342 a.a., .
ANKFY1 is a proposed Rab5 effector that critically participates in endosomal dynamics by binding to PI(3)P, promoting homotypic early endosomal fusion and participating in heterotypic fusion. It plays a crucial role in macropinocytosis, is dependent on Rab5-GTP, and is essential for the correct localization of activated tyrosine kinase receptors such as PDGFRB. ANKFY1 Protein, Human (Sf9, His, Strep) is the recombinant human-derived ANKFY1 protein, expressed by Sf9 insect cells , with N-Strep, N-8*His labeled tag. The total length of ANKFY1 Protein, Human (Sf9, His, Strep) is 1168 a.a., .
SWSAP1, an ATPase selectively activated by single-stranded DNA, is vital for homologous recombination repair (HRR). In addition to ATPase activity, SWSAP1 independently binds DNA. Teaming up with ZSWIM7, it forms a complex crucial for HRR, with mutual stabilization. SWSAP1 interacts with key HRR proteins—RAD51, RAD51B, RAD51C, RAD51D, and XRCC3—underscoring its role in facilitating homologous recombination repair processes. SWSAP1 Protein, Human (His) is the recombinant human-derived SWSAP1 protein, expressed by E. coli , with N-6*His labeled tag. The total length of SWSAP1 Protein, Human (His) is 229 a.a., with molecular weight of ~30.0 kDa.
BCL6 is a key transcriptional repressor of germinal centers and regulates multiple biological functions and lineages. It forms a complex with corepressors and histone deacetylase, directly binds to 5'-TTCCTAGAA-3', and inhibits genes involved in differentiation, inflammation, apoptosis and cell cycle control in GC B cells. BCL6 Protein, Human is the recombinant human-derived BCL6 protein, expressed by E. coli , with tag free. The total length of BCL6 Protein, Human is 706 a.a., with molecular weight of 79.0 kDa.
rHuEarly growth response protein 1/EGR1, His; EGR-1; Early growth response protein 1; Zif268; zincfinger protein 225; NGFI-A ; nerve growth factor-induced protein A;
The EGR1/ZNF225 protein is a multifunctional transcriptional regulator that binds to the EGR site in the promoter of target genes and is independent of cytosine methylation. It controls the transcription of multiple target genes, affecting responses to growth factors, DNA damage, and ischemia. EGR1/ZNF225 Protein, Human (His) is the recombinant human-derived EGR1/ZNF225 protein, expressed by E. coli , with N-6*His labeled tag. The total length of EGR1/ZNF225 Protein, Human (His) is 152 a.a., with molecular weight of ~20.0 kDa.
BCL6 is a key transcriptional repressor of germinal centers and regulates multiple biological functions and lineages. It forms a complex with corepressors and histone deacetylase, directly binds to 5'-TTCCTAGAA-3', and inhibits genes involved in differentiation, inflammation, apoptosis and cell cycle control in GC B cells. BCL6 Protein, Human (GST) is the recombinant human-derived BCL6 protein, expressed by E. coli , with N-GST labeled tag. The total length of BCL6 Protein, Human (GST) is 706 a.a., with molecular weight of ~105.5 kDa.
ZNHIT1 is a key chromatin remodeling protein that regulates gene expression by promoting the incorporation of histone variants H2AZ1/H2A.Z. In muscle differentiation, ZNHIT1 is recruited to the MYOG promoter, mediating H2AZ1 binding and inducing muscle-specific gene expression. ZNHIT1 Protein, Human (His) is the recombinant human-derived ZNHIT1 protein, expressed by E. coli , with N-6*His labeled tag. The total length of ZNHIT1 Protein, Human (His) is 154 a.a., with molecular weight of ~21.0 kDa.
DHHC20 Protein, Human (Sf9) is the recombinant human-derived DHHC20, expressed by Sf9 insect cells , with tag Free labeled tag. The total length of DHHC20 Protein, Human (Sf9) is 365 a.a.,
The RNF216 protein accepts ubiquitin from specific enzymes and transfers it to the substrate, promoting its ubiquitination. It has antiviral activity, inhibits TNF- and IL-1-mediated NF-kappa-B activation, and promotes TNF- and RIP-mediated apoptosis. RNF216 Protein, Human is the recombinant human-derived RNF216 protein, expressed by E. coli , with tag free. The total length of RNF216 Protein, Human is 865 a.a., .
The RNF216 protein accepts ubiquitin from specific enzymes and transfers it to the substrate, promoting its ubiquitination. It has antiviral activity, inhibits TNF- and IL-1-mediated NF-kappa-B activation, and promotes TNF- and RIP-mediated apoptosis. RNF216 Protein, Human (His) is the recombinant human-derived RNF216 protein, expressed by E. coli , with N-6*His labeled tag. The total length of RNF216 Protein, Human (His) is 865 a.a., .
KDM2A; Lysine-specific demethylase 2A; CXXC-type zincfinger protein 8; F-box and leucine-rich repeat protein 11; F-box protein FBL7; F-box protein Lilina; F-box/LRR-repeat protein 11; JmjC domain-containing histone demethylation protein 1A; [Histone-H3]-lysine-36 demethylase 1A
The KDM2A protein is a histone demethylase targeting "Lys-36" of histone H3. It plays a key role in the histone code, especially the demethylation of dimethylated H3 "Lys-36". Methylation. In addition to histone demethylation, KDM2A also recognizes and binds phosphorylated proteins, promoting their ubiquitination and degradation. KDM2A Protein, Human is the recombinant human-derived KDM2A protein, expressed by E. coli , with tag free. The total length of KDM2A Protein, Human is 115 a.a., .
KDM2A; Lysine-specific demethylase 2A; CXXC-type zincfinger protein 8; F-box and leucine-rich repeat protein 11; F-box protein FBL7; F-box protein Lilina; F-box/LRR-repeat protein 11; JmjC domain-containing histone demethylation protein 1A; [Histone-H3]-lysine-36 demethylase 1A
The KDM2A protein is a histone demethylase targeting "Lys-36" of histone H3. It plays a key role in the histone code, especially the demethylation of dimethylated H3 "Lys-36". Methylation. In addition to histone demethylation, KDM2A also recognizes and binds phosphorylated proteins, promoting their ubiquitination and degradation. KDM2A Protein, Human (His) is the recombinant human-derived KDM2A protein, expressed by E. coli , with N-6*His labeled tag. The total length of KDM2A Protein, Human (His) is 115 a.a., .
RBCK1 is an E3 ubiquitin protein ligase that cooperates with specific E2 enzymes such as UBE2L3/UBCM4 to transfer ubiquitin to substrates. It acts as an E3 ligase that oxidizes IREB2, relying on heme and oxygen for IREB2 ubiquitination. RBCK1 Protein, Human is the recombinant human-derived RBCK1 protein, expressed by E. coli , with tag free. The total length of RBCK1 Protein, Human is 509 a.a., .
RBCK1 is an E3 ubiquitin protein ligase that cooperates with specific E2 enzymes such as UBE2L3/UBCM4 to transfer ubiquitin to substrates. It acts as an E3 ligase that oxidizes IREB2, relying on heme and oxygen for IREB2 ubiquitination. RBCK1 Protein, Human (His) is the recombinant human-derived RBCK1 protein, expressed by E. coli , with N-6*His labeled tag. The total length of RBCK1 Protein, Human (His) is 509 a.a., .
UHRF2; E3 ubiquitin-protein ligase UHRF2; Np95/ICBP90-like RING finger protein; Np95-like RING finger protein; Nuclear protein 97; Nuclear zincfinger protein Np97; RING finger protein 107; RING-type E3 ubiquitin transferase UHRF2; Ubiquitin-like PHD and RING finger domain-containing protein 2; Ubiquitin-like-containing PHD and RING finger domains protein 2
UHRF2 protein is an E3 ubiquitin ligase involved in DNA methylation, histone modification, cell cycle regulation and DNA repair. UHRF2 Protein, Human (His, SUMO) is the recombinant human-derived UHRF2 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag. The total length of UHRF2 Protein, Human (His, SUMO) is 230 a.a., .
Endothelial Kruppel like zincfinger protein; Epithelial zincfinger protein EZF; EZF; GKLF; Gut-enriched krueppel-like factor; KLF; KLF4; KLF4_HUMAN; Krueppel-like factor 4; Kruppel like factor 4; Epithelial zincfinger protein EZF; Gut enriched Krueppel
WB
Human, Mouse, Rat
KLF4 Antibody (YA716) is a non-conjugated and Mouse origined monoclonal antibody about 55 kDa, targeting to KLF4 (3B3). It can be used for WB assays with tag free, in the background of Transfected.
zincfinger protein 160; zincfinger protein HZF5; zincfinger protein Kr18
WB, IP
Human, Mouse, Rat
ZNF160 Antibody (YA2453) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2453), targeting ZNF160, with a predicted molecular weight of 94 kDa (observed band size: 74 kDa). ZNF160 Antibody (YA2453) can be used for WB, IP experiment in human, mouse, rat background.
Sall4 Antibody (YA1899) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1899), targeting Sall4, with a predicted molecular weight of 112 kDa (observed band size: 112 kDa). Sall4 Antibody (YA1899) can be used for WB, IHC-P experiment in human background.
IKZF3; ZNFN1A3; zincfinger protein Aiolos; Ikaros family zincfinger protein 3
WB, IHC-P, ICC/IF, FC
Human, Mouse, Rat
IKZF3 Antibody (YA2116) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2116), targeting IKZF3, with a predicted molecular weight of 58 kDa (observed band size: 70 kDa). IKZF3 Antibody (YA2116) can be used for WB, IHC-P, ICC/IF, FC experiment in human, mouse, rat background.
CLL associated antigen KW 6; DNA-binding protein Ikaros; hIk 1; hIk-1; Hs.54452; IK1; Ikaros (zincfinger protein); IKAROS; IKAROS family zincfinger 1 (Ikaros); Ikaros family zincfinger protein 1; Ikzf1; IKZF1_HUMAN; LYF1; Lymphoid transcription factor LyF-1; PRO0758; zincfinger protein subfamily 1A 1 (Ikaros); zincfinger protein subfamily 1A 1; zincfinger protein; subfamily 1A; member 1; ZNFN1A1.
WB, IP
Human
Ikaros Antibody (YA987) is a mouse-derived non-conjugated IgG1 antibody (Clone NO.: YA987), targeting Ikaros, with a predicted molecular weight of 58 kDa (observed band size: 58 kDa). Ikaros Antibody (YA987) can be used for WB, IP experiment in human background.
CLL associated antigen KW 6; DNA-binding protein Ikaros; hIk 1; hIk-1; Hs.54452; IK1; Ikaros (zincfinger protein); IKAROS; IKAROS family zincfinger 1 (Ikaros); Ikaros family zincfinger protein 1; Ikzf1; IKZF1_HUMAN; LYF1; Lymphoid transcription factor LyF-1; PRO0758; zincfinger protein subfamily 1A 1 (Ikaros); zincfinger protein subfamily 1A 1; zincfinger protein; subfamily 1A; member 1; ZNFN1A1.
IHC-P
Human
Ikaros Antibody (YA988) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA988), targeting Ikaros. Ikaros Antibody (YA988) can be used for IHC-P experiment in human background.
ZIC; Zic protein member 1; zincfinger protein 201; zincfinger protein ZIC1; ZNF201
WB, ICC/IF, FC
Human, Mouse, Rat
ZIC 1 Antibody (YA3372) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3372), targeting ZIC 1, with a predicted molecular weight of 48 kDa (observed band size: 48 kDa). ZIC 1 Antibody (YA3372) can be used for WB, ICC/IF, FC experiment in human, mouse, rat background.
RNF8 Antibody (YA1344) is a biotin-conjugated non-conjugated IgG antibody, targeting RNF8, with a predicted molecular weight of 56 kDa (observed band size: 60 kDa). RNF8 Antibody (YA1344) can be used for WB experiment in human, rat background.
CTCF Antibody (YA2570) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2570), targeting CTCF, with a predicted molecular weight of 83 kDa (observed band size: 140 kDa). CTCF Antibody (YA2570) can be used for WB, IHC-F, IHC-P, ICC/IF experiment in human, mouse, rat background.
ZEB1 Antibody (YA1153) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1153), targeting ZEB1. ZEB1 Antibody (YA1153) can be used for IHC-P experiment in human background.
AFP regulator 1; zincfinger and homeodomain protein 2
WB, ICC/IF
Human, Rat
ZHX2 Antibody (YA1746) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1746), targeting ZHX2, with a predicted molecular weight of 92 kDa (observed band size: 110 kDa). ZHX2 Antibody (YA1746) can be used for WB, ICC/IF experiment in human, rat background.
E3 ubiquitin-protein ligase RNF115; Rabring 7; zincfinger protein 364
WB
Human, Rat
ZNF364 Antibody (YA1579) is a biotin-conjugated non-conjugated IgG antibody, targeting ZNF364, with a predicted molecular weight of 34 kDa (observed band size: 34 kDa). ZNF364 Antibody (YA1579) can be used for WB experiment in human, rat background.
BCL6; BCL5; LAZ3; ZBTB27; ZNF51; B-cell lymphoma 6 protein; BCL-6; B-cell lymphoma 5 protein; BCL-5; Protein LAZ-3; zincfinger and BTB domain-containing protein 27; zincfinger protein 51
IHC-P
Human
Bcl6 Antibody (YA1281) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1281), targeting Bcl6. Bcl6 Antibody (YA1281) can be used for IHC-P experiment in human background.
DBF4; ASK; DBF4A; ZDBF1; Protein DBF4 homolog A; Activator of S phase kinase; Chiffon homolog A; DBF4-type zincfinger-containing protein 1
WB
Human
DBF4 Antibody (YA2652) is a biotin-conjugated non-conjugated IgG antibody, targeting DBF4, with a predicted molecular weight of 77 kDa (observed band size: 77 kDa). DBF4 Antibody (YA2652) can be used for WB experiment in human background.
CHD3 Antibody (YA944) is a mouse-derived non-conjugated IgG1 antibody (Clone NO.: YA944), targeting CHD3, with a predicted molecular weight of 227 kDa (observed band size: 260 kDa). CHD3 Antibody (YA944) can be used for WB, ICC/IF, IP experiment in human, mouse, rat background.
CHD3 Antibody (YA945) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA945), targeting CHD3, with a predicted molecular weight of 227 kDa (observed band size: 260 kDa). CHD3 Antibody (YA945) can be used for WB, IHC-P, ICC/IF, FC experiment in human, mouse, rat background.
SP7/Osterix Antibody is an unconjugated, approximately 45 kDa, rabbit-derived, anti-SP7/Osterix monoclonal antibody. SP7/Osterix Antibody can be used for: WB, IHC-P, IF-Tissue, IHC-Fr expriments in human, mouse, and rat background without labeling.
CSDD1; FLJ12457; LIN 28; Lin-28A; LIN28; LIN28A; LN28A_HUMAN; Protein lin-28 homolog A; ZCCHC1; zincfinger CCHC domain-containing protein 1.
WB
Human, Mouse
LIN28A Antibody (YA711) is a non-conjugated and Mouse origined monoclonal antibody about 23 kDa, targeting to LIN28A (2C1). It can be used for WB assays with tag free, in the background of Human, Mouse.
EGR2; KROX20; E3 SUMO-protein ligase EGR2; AT591; E3 SUMO-protein transferase ERG2 Curated; Early growth response protein 2 (EGR-2); zincfinger protein Krox-20;
WB
Human, Mouse, Rat
EGR2 Antibody (YA1926) is a biotin-conjugated non-conjugated IgG antibody, targeting EGR2, with a predicted molecular weight of 50 kDa (observed band size: 53 kDa). EGR2 Antibody (YA1926) can be used for WB experiment in human, mouse, rat background.
SNAI1_HUMAN; zincfinger protein SNAI1; SNAI1; SNAH; SNAI 1; SNA; SNAIL1; dJ710H13.1; Protein snail homolog 1 (Protein sna); Protein snail homolog 1; Protein sna
WB, IHC-P, ICC/IF, ELISA
Human, Mouse
SNAI1 Antibody is an unconjugated, approximately 29 kDa, rabbit-derived, anti-SNAI1 polyclonal antibody. SNAI1 Antibody can be used for: WB,IHC-P,ICC/IF,ELISA expriments in human,and mouse background without labeling.
TNFAIP3; OTUD7C; Tumor necrosis factor alpha-induced protein 3; TNF alpha-induced protein 3; OTU domain-containing protein 7C; Putative DNA-binding protein A20; zincfinger protein A20
WB, IHC-F, IHC-P, ICC/IF
Human
TNFAIP3 Antibody (YA2231) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2231), targeting TNFAIP3, with a predicted molecular weight of 90 kDa (observed band size: 82 kDa). TNFAIP3 Antibody (YA2231) can be used for WB, IHC-F, IHC-P, ICC/IF experiment in human background.
RCHY1; ARNIP; CHIMP; PIRH2; RNF199; ZNF363; RING finger and CHY zincfinger domain-containing protein 1; Androgen receptor N-terminal-interacting protein; CH-rich-interacting match with PLAG1; E3 ubiquitin-protein ligase Pirh2; RING finger
WB
Human
Pirh2 Antibody (YA1743) is a biotin-conjugated non-conjugated IgG antibody, targeting Pirh2, with a predicted molecular weight of 30 kDa (observed band size: 30 kDa). Pirh2 Antibody (YA1743) can be used for WB experiment in human background.
TRIM25; EFP; RNF147; ZNF147; E3 ubiquitin/ISG15 ligase TRIM25; Estrogen-responsive finger protein; RING finger protein 147; Tripartite motif-containing protein 25; Ubiquitin/ISG15-conjugating enzyme TRIM25; zincfinger protein 147
WB, ICC/IF, IP
Human, Rat
TRIM25 Antibody (YA2278) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2278), targeting TRIM25, with a predicted molecular weight of 71 kDa (observed band size: 71 kDa). TRIM25 Antibody (YA2278) can be used for WB, ICC/IF, IP experiment in human, rat background.
PRDM1/Blimp1 Antibody (YA1101) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1101), targeting PRDM1/Blimp1. PRDM1/Blimp1 Antibody (YA1101) can be used for IHC-P experiment in human background.
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