β-Thujaplicinol (Synonyms: 3-Hydroxy-5-isopropyltropolone)

Cat. No.: HY-W060316: FAQs
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β-Thujaplicinol (3-Hydroxy-5-isopropyltropolone) is an inhibitor of hepatitis B virus (HBV) ribonuclease H. β-Thujaplicinol inhibits RNAseHs of HBV genotypes D and H with IC₅₀ values of 5.9 and 2.3 μM, respectively.

For research use only. We do not sell to patients.

β-Thujaplicinol Chemical Structure

CAS No. : 29346-20-1

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Biological Activity
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References
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Description

Cellular Effect

Cell Line	Type	Value	Description	References
MT4	CC₅₀	2.5 μM Compound: 1	Cytotoxicity against human MT4 cells assessed as reduction in cell viability measured after 5 days by MTT assay Cytotoxicity against human MT4 cells assessed as reduction in cell viability measured after 5 days by MTT assay	[PMID: 35780636]
MT4	CC₅₀	2.83 μM Compound: Fig 1, Cpd 2	Cytotoxicity in mock-infected human MT4 cells assessed as reduction in cell viability incubated for 5 days by MTT assay Cytotoxicity in mock-infected human MT4 cells assessed as reduction in cell viability incubated for 5 days by MTT assay	[PMID: 31324562]
Vero	CC₅₀	> 100 μM Compound: beta-thujaplicinol	Cytotoxicity against African green monkey Vero cells incubated for 24 hrs by MTT assay Cytotoxicity against African green monkey Vero cells incubated for 24 hrs by MTT assay	[PMID: 31391890]
Vero	EC₅₀	1.7 μM Compound: beta-thujaplicinol	Inhibition of NTS in HSV-2 infected in African green monkey Vero cells assessed as suppression of viral replication by measuring viral titer after 24 hrs by plaque reduction assay based phase contrast microscopy Inhibition of NTS in HSV-2 infected in African green monkey Vero cells assessed as suppression of viral replication by measuring viral titer after 24 hrs by plaque reduction assay based phase contrast microscopy	[PMID: 31391890]
Vero	EC₅₀	2 μM Compound: beta-thujaplicinol	Inhibition of NTS in HSV-1 infected in African green monkey Vero cells assessed as suppression of viral replication by measuring viral titer after 24 hrs by plaque reduction assay based phase contrast microscopy Inhibition of NTS in HSV-1 infected in African green monkey Vero cells assessed as suppression of viral replication by measuring viral titer after 24 hrs by plaque reduction assay based phase contrast microscopy	[PMID: 31391890]

Molecular Weight

180.20

Formula

C₁₀H₁₂O₃

CAS No.

29346-20-1

SMILES

CC(C1=CC(C(O)=C(C=C1)O)=O)C

Structure Classification

Ketones, Aldehydes, Acids

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Hu Y, et al. β-Thujaplicinol inhibits hepatitis B virus replication by blocking the viral ribonuclease H activity[J]. Antiviral research, 2013, 99(3): 221-229. [Content Brief]

β-Thujaplicinol Related Classifications

Infection

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

β-Thujaplicinol29346-20-13-Hydroxy-5-isopropyltropoloneHBVDNA/RNA SynthesisHepatitis B virusinhibitorsviral replicationnuclease HInhibitorinhibitorinhibit

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