p38 MAPK

MAPK

p38 MAPK

p38 MAPK Isoform Specific Products:

p38 MAPK Related Products (568)
Recombinant Proteins (4)
Antibodies (20)
p38 MAPK Isoform Comparison

By Effects:	Control (1) Inhibitors (416) Agonists (3) Degrader (1) Activators (94) Modulators (5) p53 Inhibitor (1) Inducers (8)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-10401

VX-702	Inhibitor	99.54%
VX-702 is a highly selective inhibitor of p38α MAPK, 14-fold higher potency against the p38α versus p38β.

HY-14654R

Aspirin (Standard)	Activator	99.85%
Aspirin (Standard) is the analytical standard of Aspirin. This product is intended for research and analytical applications. Aspirin (Acetylsalicylic Acid) is an orally active, potent and irreversible inhibitor of cyclooxygenase COX-1 and COX-2, with IC₅₀ values of 5 and 210 μg/mL, respectively. Aspirin induces apoptosis. Aspirin inhibits the activation of NF-κB. Aspirin also inhibits platelet prostaglandin synthetase, and can prevent coronary artery and cerebrovascular thrombosis.

HY-111431A

p-Cresyl sulfate potassium	Activator	99.92%
p-Cresyl sulfate potassium is a uremic toxin that binds to a prototype protein. p-Cresyl sulfate potassium activates the JNK and p38 MAPK signaling pathways. p-Cresyl sulfate potassium has pro-inflammatory activity.

HY-N0890

Tubeimoside I	Inhibitor	99.96%
Tubeimoside I is an orally active HSPD1 inhibitor. Tubeimoside I inhibits NF-κB, MAPK, as well as regulates eNOS-VEGF. Tubeimoside I induces cytoprotective Autophagy via an Akt-mediated pathway. Tubeimoside I inhibits proinflammatory cytokine (IL-6 and IL-1β) production. Tubeimoside I exhibits anti-inflammatory activities. Tubeimoside I promotes angiogenesis and improves sepsis symptoms. Tubeimoside I is used in the research of inflammatory diseases, various cancers, sepsis and ischemic diseases.

HY-W007355

Skatole	Activator	99.97%
Skatole (3-methylindole) is a heterocyclic compound naturally found in the feces of vertebrates and can be found in certain plants. Skatole can be produced by intestinal bacteria, inducing apoptosis of intestinal epithelial cells through activating aryl hydrocarbon receptors (AhR) and p38. Skatole has been used in specific products of the perfume industry or as a flavor additive in ice cream.

HY-N0031

Plantamajoside		99.80%
Plantamajoside is an orally active phenylpropanoid glycoside. Plantamajoside can be isolated from Plantago asiatica L.(Plantaginaceae). Plantamajoside inactivates NF-κB, PI3K/akt, induces Apoptosis, and improves Autophagy. Plantamajoside regulates MAPK, integrin-linked kinase/c-Src. Plantamajoside inhibits multiple cancers, improves lung and kidney damage. Plantamajoside has neuroprotective and anti-inflammatory effects.

HY-A0012

Darifenacin hydrobromide	Inhibitor	99.97%
Darifenacin (UK-88525) hydrobromide is a selective and orally active M3 muscarinic receptor (M3R) antagonist with a pKi of 8.9. Darifenacin hydrobromide binds >20-fold more specifically to M3R than to other muscarinic receptors. Darifenacin hydrobromide can be used in the study of urinary incontinence and other symptoms of overactive bladder. Darifenacin hydrobromide inhibits tumor growth in colorectal cancer cells and has anti-tumor effects.

HY-N0022

Isoacteoside	Inhibitor	99.73%
Isoacteoside is a natural product that can significantly inhibit the formation of glycation end products. Isoacteoside regulates the AKT/PI3K/m-TOR/NF-κB signaling pathway, induces apoptosis in OVCAR-3 cell. Isoacteoside exhibits antitumor, anti-inflammatory, anti-obesity and neuroprotective activities.

HY-P10408

Candidalysin	Activator	99.38%
Candidalysin is a cytolytic peptide toxin secreted by the fungus Candida albicans. Candidalysin drives epithelial immune responses by activating the EGFR-MAPK signaling pathway, inducing MMP expression and calcium influx, and regulating the c-Fos transcription factor and MKP1 via p38 MAPK and ERK1/2 respectively. Candidalysin is essential for mucosal and systemic infections, activating NLRP3 to promote inflammatory responses, neutrophil recruitment, and Th17 immunity. Candidalysin activates LDH causing membrane damage and exhibiting cytotoxicity

HY-107427

PF-3644022	Inhibitor	99.65%
PF-3644022 is a potent, selective, orally active and ATP-competitive MAPKAPK2 (MK2) inhibitor with an IC₅₀ of 5.2 nM and a K_i of 3 nM. PF-3644022 also inhibits MK3 and p38 regulated/activated kinase (PRAK) with IC₅₀s of 53 nM and 5.0 nM, respectively. PF-3644022 potently inhibits TNFα production and has anti-inflammatory effect.

HY-152185

BSJ-04-122		99.86%
BSJ-04-122 is a covalent MKK4/7 dual inhibitor. BSJ-04-122 inhibits MKK4 and MKK7 with IC₅₀ values of 4 nM and 181 nM, respectively. BSJ-04-122 can be used for the research of cancer.

HY-116522

AR420626		98.29%
AR420626 is a selective agonist of free fatty acid receptor 3 (FFAR3) (IC₅₀=117 nM). AR420626 has anti-inflammatory, anticancer and antidiabetic activities. AR420626 improves neurogenic diarrhea by inhibiting nAChR mediated neural pathways. AR420626 inhibits the growth of HepG2 xenografts and inhibits the proliferation of hepatoma cells by inducing apoptosis. AR420626 also suppresses allergic asthma and eczema and has the ability to activate GPR41 to increase Ca²⁺ signal-mediated glucose uptake and improve diabetes.

HY-N0188

Esculin	Inhibitor	99.47%
Esculin is a fluorescent coumarin glucoside, the active ingredient in ash bark. Esculin has antidiabetic effects, improves cognitive impairment in experimental diabetic nephropathy (DN) via the MAPK signaling pathway, and exerts antioxidant stress and anti-inflammatory effects. Esculin also has anticancer, antibacterial, antiviral, neuroprotective, antithrombotic, and therapeutic properties for eye diseases.

HY-113556

Sappanone A	Inhibitor	99.87%
Sappanone A is an orally active homoisoflavone found in sappan L. Sappanone A is a PDE4 and NF-κB inhibitor with anti-inflammatory and antioxidant effect. Sappanone A induces HO-1 expression through activation of Nrf2 pathway. Sappanone A also inhibits RANKL-induced osteoclastogenesis. Sappanone A has great potential in the research of inflammation-related and cardiovascular .

HY-N8518

Malabaricone C	Inhibitor	99.61%
Malabaricone C is an orally active and noncompetitive sphingomyelin synthase (SMS) inhibitor with IC₅₀ values of 3 μM and 1.5 μM for SMS 1 and SMS 2, respectively. Malabaricone C reduces body weight gain, improves glucose tolerance, and decreases lipid accumulation in the liver, showing significant prevention of high fat diet-induced fatty liver in mice. Malabaricone C has anti-inflammatory effects, which is found in the fruits of Myristica cinnamomea King. Malabaricone C is promising for research of obesity and immunological disorders caused due to hyper-activation of T-cells.

HY-N0638

Dendrobine	Activator	99.92%
Dendrobine is an alkaloid isolated from Dendrobium nobile. Dendrobine possesses antiviral activity against influenza A viruses, with IC₅₀s of 3.39 μM, 2.16 μM and 5.32 μM for A/FM-1/1/47 (H1N1), A/Puerto Rico/8/34 H274Y (H1N1) and A/Aichi/2/68 (H3N2), respectively. Dendrobine activates the JNK/p38/Nrf2 signaling pathway. Dendrobine exhibits antiviral, antitumor, anti-inflammatory, and neuroprotective properties.

HY-N0755

Rhoifolin	Activator	99.25%
Rhoifolin is a flavone glycoside can be isolated from Rhus succedanea. Rhoifolin has anti-diabetic effect acting through enhanced adiponectin secretion, tyrosine phosphorylation of insulin receptor-β and glucose transporter 4 (GLUT 4) translocation. Rhoifolin has an anti-inflammatory action via multi-level regulation of inflammatory mediators. Rhoifolin ameliorates titanium particle-stimulated osteolysis and attenuates osteoclastogenesis via RANKL-induced NF-κB and MAPK pathways. Rhoifolin also has cytotoxic activity against different cancer cell lines.

HY-N0498

Nitidine chloride	Inhibitor	99.75%
Nitidine chloride, a potential anti-malarial lead compound derived from Zanthoxylum nitidum (Roxb) DC, exerts potent anticancer activity through diverse pathways, including inducing apoptosis, inhibiting STAT3 signaling cascade, DNA topoisomerase 1 and 2A, ERK and c-Src/FAK associated signaling pathway, also has anti-inflammatory activity. Nitidine chloride inhibits LPS-induced inflammatory cytokines production via MAPK and NF-kB pathway.

HY-B0435

Roxithromycin	Activator	99.86%
Roxithromycin (RU-28965) is an orally active semi-synthethic macrolide antibiotic. Roxithromycin inhibits protein biosynthesis in the elongation step by binding to 50S bacterial ribosome. Roxithromycin has antimicrobial, antiproliferative, anti-inflammatory, tumour vasculature inhibiting and lung injury ameliorating effects.

HY-N0235

Bakuchiol	Inhibitor	99.25%
Bakuchiol is a phytoestrogen that can be obtained from psoralen seeds. Bakuchiol has been proven to be a non-competitive inhibitor of multiple enzymes, including UDP-glucuronosyltransferase 2B7 (UGT2B7) and human carboxylesterase 2 (hCE2) , with IC₅₀s values of 40.9 μM and 7.28 μM, respectively. Bakuchiol exhibits significant research and application potential in areas such as anti-inflammatory, antibacterial, antitumor therapies, as well as drug metabolism regulation.

Adezmapimod	p38, IC₅₀: 50 nM		p38β2, IC₅₀: 500 nM				99.96%
SB 202190		p38α, IC₅₀: 50 nM	p38β2, IC₅₀: 100 nM				99.89%
Doramapimod	p38 MAP kinase, Kd: 0.1 nM	p38α, IC₅₀: 38 nM	p38β, IC₅₀: 65 nM		p38δ, IC₅₀: 520 nM	p38γ, IC₅₀: 200 nM	99.98%
Adezmapimod hydrochloride	p38, IC₅₀: 50 nM		p38β2, IC₅₀: 500 nM				99.71%
Muramyl dipeptide	p38 MAPK						≥98.0%
Diprovocim	p38 MAPK						98.82%
Naporafenib		p38α, IC₅₀: 2.1 μM					99.86%
Ralimetinib dimesylate		p38α MAPK, IC₅₀: 5.3 nM	p38β MAPK, IC₅₀: 3.2 nM				99.94%
Neflamapimod		p38α, IC₅₀: 10 nM	p38β, IC₅₀: 220 nM				99.32%
Exarafenib	p38 MAPK						99.68%
Skatole	p38						99.97%
Esculin	p38 MAPK						99.47%
Talmapimod		p38α, IC₅₀: 9 nM	p38β, IC₅₀: 90 nM				98.68%
p38 MAPK-IN-1	p38 MAPK, IC₅₀: 68 nM						99.58%
SB 202190 hydrochloride		p38α, IC₅₀: 50 nM	p38β2, IC₅₀: 100 nM				99.66%
Tpl2 Kinase Inhibitor 1	p38, IC₅₀: 180 μM						99.22%
Paris saponin VII	p38						99.96%
AMG-548 dihydrochloride		p38α, Ki: 0.5 nM dog p38α, Ki: 5.0 nM	p38β, Ki: 3.6 nM		p38δ, Ki: 2600 nM	p38γ, Ki: 4100 nM	99.86%
Broussonin E	p38 MAPK						98.18%
Semapimod tetrahydrochloride	p38 MAPK						98.43%
TAK-715		p38α, IC₅₀: 7.1 nM	p38β, IC₅₀: 200 nM		p38δ, IC₅₀: >10 μM	p38γ, IC₅₀: >10 μM	99.76%
Gossypetin	p38 MAP kinase						99.82%
Peimine	p38						99.43%
Dihydrocaffeic acid	p38 MAPK						99.65%
Teneligliptin hydrobromide	p38 MAPK						99.99%
MAPK13-IN-1				MAPK13 (p38δ), IC₅₀: 620 nM			98.93%
Pamapimod		p38α, IC₅₀: 14 nM p38α, Ki: 1.3 nM	p38β, IC₅₀: 480 p38β, Ki: 120 nM				99.92%
NF-κB/MAPK-IN-1	p38						98.42%
UM-164		p38α	p38β				99.15%
Cornuside	p38 MAP kinase						99.99%
SM-7368	p38 MAP kinase						99.77%
Ferulic acid methyl ester	p38						99.95%
Emprumapimod		p38α					99.04%
EW-7195		p38α, IC₅₀: 1.5 μM					98.84%
SR-318		p38α, IC₅₀: 5 nM	p38β, IC₅₀: 32 nM				99.89%
BMS-582949 hydrochloride		p38α MAPK, IC₅₀: 13 nM					98.90%
CK1-IN-1		p38α MAPK, IC₅₀: 73 nM					99.19%
N-Feruloyloctopamine	p38 MAPK						99.91%
Isoliquiritin apioside	p38 MAPK						99.87%
MW-150		p38α, Ki: 101 nM					99.89%
MKK7-COV-9	p38 MAP kinase
R1487 Hydrochloride		p38α, Kd: 0.2 nM	p38β, Kd: 29 nM				99.33%
TA-01	p38 MAP kinase, IC₅₀: 6.7 nM						99.86%
SJFα		p38α, DC₅₀: 7.16 nM			p38δ, DC₅₀: 299 nM		99.61%
RWJ-67657		p38α, IC₅₀: 1 μM	p38β, IC₅₀: 11 μM				99.75%
JNJ-49095397		p38α				p38γ	99.85%
Rotundic acid	p38 MAPK						99.41%
p38α inhibitor 2		p38α MAPK, pIC₅₀: 9.6					98.03%
Anti-inflammatory agent 35	p38 MAPK						99.77%
p38 MAP Kinase Inhibitor III	p38 MAP kinase, IC₅₀: 0.9 μM						98.77%
SD-169		p38α MAPK, IC₅₀: 3.2 nM	p38β MAPK, IC₅₀: 122 nM				99.91%
PF-05381941		p38α, IC₅₀: 186 nM					99.73%
p38 MAP Kinase Inhibitor IV		p38α, IC₅₀: 0.13 μM	p38β, IC₅₀: 0.55 μM		p38δ, IC₅₀: 8.63 μM		98.0%
AMG-548		p38α, Ki: 0.5 nM dog p38α, Ki: 5.0 nM	p38β, Ki: 3.6 nM		p38δ, Ki: 2600 nM	p38γ, Ki: 4100 nM	≥99.0%
SB 220025	p38, IC₅₀: 60 nM						99.90%
p38 MAPK-IN-4	p38, IC₅₀: 35 nM						98.45%
p38α inhibitor 1		p38α					98.91%
AL 8697		p38α, IC₅₀: 6 nM	p38β, IC₅₀: 82 nM				99.83%
Emprumapimod hydrochloride		p38α					≥98.0%
SX 011		p38α, IC₅₀: 9 nM	p38β, IC₅₀: 90 nM		p38δ, IC₅₀: > 300 (Pan)	p38γ, IC₅₀: > 300 (Pan)	99.33%
NR-11c		p38α					99.75%
Sugiol	p38 MAPK						99.88%
MW-150 hydrochloride		p38α, Ki: 101 nM
MW-150 dihydrochloride dihydrate		p38α, Ki: 101 nM
Ralimetinib		p38α MAPK, IC₅₀: 5.3 nM	p38β MAPK, IC₅₀: 3.2 nM
Talmapimod hydrochloride		p38α, IC₅₀: 9 nM	p38β, IC₅₀: 90 nM
Casein kinase 1δ-IN-27		p38α, IC₅₀: 14.8 nM
p38-α MAPK-IN-4		p38α MAPK, IC₅₀: 1.5 μM
Casein kinase 1δ-IN-29		p38α, IC₅₀: 0.041 μM
Halociline	p38 MAP kinase
SJFδ		p38α, DC₅₀: 46.17 nM
p38-α MAPK-IN-5		p38α, IC₅₀: 0.1 nM	p38β, IC₅₀: 0.2 nM		p38δ, IC₅₀: 4100 nM	p38γ, IC₅₀: 944 nM
p38 MAPK-IN-3		p38α MAPK
SB-284851-BT		p38α, Kd: 0.47 nM
J-1149		p38α MAPK
p38α inhibitor 7		p38α
MW108 hydrochloride		p38α MAPK, Ki: 114 nM
p38α-MK2-IN-1		p38α
DCZ19931	p38 MAPK
Lucidone	p38 MAPK
AMG-548 hydrochloride		p38α, Ki: 0.5 nM dog p38α, Ki: 5.0 nM	p38β, Ki: 3.6 nM		p38δ, Ki: 2600 nM	p38γ, Ki: 4100 nM
CHMFL-ABL-053	p38, IC₅₀: 62 nM
Semapimod	p38 MAPK
NDs-IN-1	p38 MAPK
(aS)-PH-797804		p38α, IC₅₀: 26 nM	p38β, IC₅₀: 102 nM
JNK3 inhibitor-5		p38α, IC₅₀: 215.8 nM
Balanophonin	p38
Doramapimod (GMP)		p38α, IC₅₀: 38 nM	p38β, IC₅₀: 65 nM		p38δ, IC₅₀: 520 nM	p38γ, IC₅₀: 200 nM
PF-03715455		p38α, IC₅₀: 0.88 nM	p38β, IC₅₀: 23 nM
SR-302		p38α, IC₅₀: 125 nM
BMS-582949		p38α, IC₅₀: 13 nM
CK1δ-IN-9		p38α, IC₅₀: 0.25 μM	p38β, IC₅₀: 0.78 μM
Cudraflavone B	p38 MAP kinase
p38α inhibitor 4		p38α, IC₅₀: 1.2 μM
Casein kinase 1δ-IN-31		p38α, IC₅₀: 18 nM
p38α inhibitor 8		p38α, IC₅₀: 0.21 μM
p38-α MAPK-IN-10		p38α, IC₅₀: 4 nM

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p38 MAPK

p38 MAPK

p38 MAPK Isoform Specific Products:

p38 MAPK Isoform Specific Products:

p38 MAPK Related Products (568)

Recombinant Proteins (4)

Antibodies (20)

p38 MAPK Isoform Comparison

p38 MAPK Related Products (568):