Bax - BCL2-associated X protein Gene

Mus musculus

Gene ID: 12028 | Gene type: protein coding

About Bax

Chromosome 7: 45,111,121-45,116,322 reverse strand.GRCm39:CM001000.3

This gene has 6 transcripts (splice variants), 206 orthologues, 10 paralogues and is associated with 27 phenotypes. Ubiquitous expression in ovary adult (RPKM 2.8), placenta adult (RPKM 19.6) and 28 other tissues.

Summary

Enables HSP70 protein binding activity; chaperone binding activity; and identical protein binding activity. Involved in activation of cysteine-type endopeptidase activity involved in apoptotic process. Acts upstream of or within several processes, including animal organ development; apoptotic signaling pathway; and regulation of apoptotic process. Located in cytosol; endoplasmic reticulum; and mitochondrial outer membrane. Part of Bax complex. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; ataxia telangiectasia; colon adenocarcinoma; colorectal cancer; and lung non-small cell carcinoma. Orthologous to human Bax (BCL2 associated X, Apoptosis regulator). [provided by Alliance of Genome Resources, Apr 2022]

Bax Products(4)

mRNA	Protein	Name
NM_001411996.1	NP_001398925.1	apoptosis regulator BAX isoform 4
NM_001411994.1	NP_001398923.1	apoptosis regulator BAX isoform 2
NM_007527.4	NP_031553.1	apoptosis regulator BAX isoform 1
NM_001411995.1	NP_001398924.1	apoptosis regulator BAX isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables Hsp70 protein binding	IDA IDA: Inferred from direct assay	14752510	MGI
enables identical protein binding	IPI IPI: Inferred from physical interaction	8631771	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	7650488	MGI
enables protein-folding chaperone binding	IPI IPI: Inferred from physical interaction	14752510	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of B cell apoptotic process	IGI IGI: Inferred from genetic interaction	11604501	MGI
acts upstream of or within B cell apoptotic process	IGI IGI: Inferred from genetic interaction	16055554	MGI
acts upstream of or within B cell homeostasis	IGI IGI: Inferred from genetic interaction	15967824	MGI
acts upstream of or within B cell homeostasis	IMP IMP: Inferred from mutant phenotype	16055554	MGI
acts upstream of or within B cell homeostatic proliferation	IMP IMP: Inferred from mutant phenotype	7569956	MGI
acts upstream of or within B cell negative selection	IGI IGI: Inferred from genetic interaction	16055554	MGI
acts upstream of or within DNA damage response	IMP IMP: Inferred from mutant phenotype	9454845	MGI
acts upstream of or within Sertoli cell proliferation	IGI IGI: Inferred from genetic interaction	11784036	MGI
acts upstream of or within T cell homeostatic proliferation	IMP IMP: Inferred from mutant phenotype	7569956	MGI
involved in activation of cysteine-type endopeptidase activity involved in apoptotic process	IDA IDA: Inferred from direct assay	16735463	MGI
acts upstream of or within activation of cysteine-type endopeptidase activity involved in apoptotic process	IGI IGI: Inferred from genetic interaction	12847083	MGI
acts upstream of or within activation of cysteine-type endopeptidase activity involved in apoptotic process	IMP IMP: Inferred from mutant phenotype	14502238	MGI
acts upstream of or within activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c	IDA IDA: Inferred from direct assay	9560217	MGI
acts upstream of or within activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c	IMP IMP: Inferred from mutant phenotype	11836241	MGI
acts upstream of or within activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	10479688	MGI
acts upstream of or within apoptotic mitochondrial changes	IDA IDA: Inferred from direct assay	12925707	MGI
acts upstream of or within apoptotic process	IDA IDA: Inferred from direct assay	9560217	MGI
acts upstream of apoptotic process	IGI IGI: Inferred from genetic interaction	17107997	MGI
acts upstream of apoptotic process	IMP IMP: Inferred from mutant phenotype	9988273	MGI
acts upstream of or within apoptotic process	IMP IMP: Inferred from mutant phenotype	10201940	MGI
acts upstream of or within apoptotic process involved in blood vessel morphogenesis	IGI IGI: Inferred from genetic interaction	15955981	MGI
acts upstream of or within apoptotic process involved in embryonic digit morphogenesis	IGI IGI: Inferred from genetic interaction	15967824	MGI
acts upstream of apoptotic process involved in mammary gland involution	IMP IMP: Inferred from mutant phenotype	10363969	MGI
acts upstream of apoptotic signaling pathway	IGI IGI: Inferred from genetic interaction	18436203	MGI
acts upstream of or within apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	12925707	MGI
acts upstream of or within blood vessel remodeling	IGI IGI: Inferred from genetic interaction	15955981	MGI
acts upstream of calcium ion transport into cytosol	IGI IGI: Inferred from genetic interaction	15613488	MGI
acts upstream of or within cell population proliferation	IGI IGI: Inferred from genetic interaction	10762311	MGI
acts upstream of or within cellular response to UV	IGI IGI: Inferred from genetic interaction	14963330	MGI
acts upstream of or within cerebral cortex development	IMP IMP: Inferred from mutant phenotype	15342910	MGI
acts upstream of or within development of secondary sexual characteristics	IMP IMP: Inferred from mutant phenotype	15944391	MGI
acts upstream of or within ectopic germ cell programmed cell death	IGI IGI: Inferred from genetic interaction	14660547	MGI
acts upstream of ectopic germ cell programmed cell death	IMP IMP: Inferred from mutant phenotype	9988273	MGI
acts upstream of or within ectopic germ cell programmed cell death	IMP IMP: Inferred from mutant phenotype	14660547	MGI
acts upstream of epithelial cell apoptotic process	IMP IMP: Inferred from mutant phenotype	9988273	MGI
acts upstream of or within epithelial cell proliferation	IDA IDA: Inferred from direct assay	9176392	MGI
acts upstream of establishment of localization in cell	IGI IGI: Inferred from genetic interaction	15613488	MGI
acts upstream of establishment of localization in cell	IMP IMP: Inferred from mutant phenotype	15947791	MGI
acts upstream of or within extrinsic apoptotic signaling pathway in absence of ligand	IGI IGI: Inferred from genetic interaction	15680329	MGI
acts upstream of or within extrinsic apoptotic signaling pathway via death domain receptors	IDA IDA: Inferred from direct assay	10597216	MGI
acts upstream of or within fertilization	IGI IGI: Inferred from genetic interaction	10894153	MGI
acts upstream of or within germ cell development	IGI IGI: Inferred from genetic interaction	10894153	MGI
acts upstream of or within glycosphingolipid metabolic process	IMP IMP: Inferred from mutant phenotype	18308723	MGI
acts upstream of or within homeostasis of number of cells	IGI IGI: Inferred from genetic interaction	11163212	MGI
acts upstream of or within homeostasis of number of cells	IMP IMP: Inferred from mutant phenotype	10931486	MGI
acts upstream of or within homeostasis of number of cells within a tissue	IMP IMP: Inferred from mutant phenotype	11413548	MGI
acts upstream of or within hypothalamus development	IMP IMP: Inferred from mutant phenotype	15342910	MGI
acts upstream of intrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	14502238	MGI
acts upstream of or within intrinsic apoptotic signaling pathway by p53 class mediator	IMP IMP: Inferred from mutant phenotype	10479688	MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage	IGI IGI: Inferred from genetic interaction	15901672	MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage	IMP IMP: Inferred from mutant phenotype	12952892	MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IGI IGI: Inferred from genetic interaction	12847083	MGI
acts upstream of or within kidney development	IGI IGI: Inferred from genetic interaction	9241272	MGI
acts upstream of or within leukocyte homeostasis	IGI IGI: Inferred from genetic interaction	11163212	MGI
acts upstream of or within limb morphogenesis	IGI IGI: Inferred from genetic interaction	11163212	MGI
acts upstream of or within male gonad development	IGI IGI: Inferred from genetic interaction	9241272	MGI
acts upstream of or within male gonad development	IMP IMP: Inferred from mutant phenotype	16270031	MGI
acts upstream of or within mitochondrial fusion	IGI IGI: Inferred from genetic interaction	16893972	MGI
acts upstream of or within mitochondrion organization	IGI IGI: Inferred from genetic interaction	20671748	MGI
acts upstream of motor neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	15944391	MGI
acts upstream of or within motor neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	12917363	MGI
acts upstream of or within myeloid cell homeostasis	IGI IGI: Inferred from genetic interaction	15967824	MGI
acts upstream of or within negative regulation of apoptotic signaling pathway	IGI IGI: Inferred from genetic interaction	18436203	MGI
acts upstream of or within negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	10762311	MGI
acts upstream of or within negative regulation of endoplasmic reticulum calcium ion concentration	IGI IGI: Inferred from genetic interaction	15613488	MGI
acts upstream of or within negative regulation of fibroblast proliferation	IMP IMP: Inferred from mutant phenotype	12952892	MGI
acts upstream of or within negative regulation of neuron apoptotic process	IDA IDA: Inferred from direct assay	8625820	MGI
acts upstream of or within negative regulation of peptidyl-serine phosphorylation	IGI IGI: Inferred from genetic interaction	15613488	MGI
acts upstream of or within nervous system development	IMP IMP: Inferred from mutant phenotype	12810599	MGI
acts upstream of neuron apoptotic process	IDA IDA: Inferred from direct assay	8625820	MGI
acts upstream of neuron apoptotic process	IGI IGI: Inferred from genetic interaction	9096145	MGI
acts upstream of or within neuron apoptotic process	IGI IGI: Inferred from genetic interaction	10762311	MGI
acts upstream of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	9699561	MGI
acts upstream of or within neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	10479688	MGI
acts upstream of or within neuron migration	IMP IMP: Inferred from mutant phenotype	15590937	MGI
acts upstream of or within odontogenesis of dentin-containing tooth	IGI IGI: Inferred from genetic interaction	15967824	MGI
acts upstream of or within ovarian follicle development	IGI IGI: Inferred from genetic interaction	10894153	MGI
acts upstream of or within ovarian follicle development	IMP IMP: Inferred from mutant phenotype	17244737	MGI
acts upstream of peptidyl-serine phosphorylation	IGI IGI: Inferred from genetic interaction	15613488	MGI
acts upstream of or within positive regulation of B cell apoptotic process	IGI IGI: Inferred from genetic interaction	11604501	MGI
acts upstream of or within positive regulation of apoptotic process	IDA IDA: Inferred from direct assay	15753097	MGI
acts upstream of or within positive regulation of apoptotic process	IGI IGI: Inferred from genetic interaction	8798452	MGI
acts upstream of or within positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	9241272	MGI
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	26949185	MGI
acts upstream of or within positive regulation of apoptotic process involved in mammary gland involution	IMP IMP: Inferred from mutant phenotype	10363969	MGI
acts upstream of or within positive regulation of calcium ion transport into cytosol	IGI IGI: Inferred from genetic interaction	15613488	MGI
acts upstream of or within positive regulation of developmental pigmentation	IGI IGI: Inferred from genetic interaction	9241272	MGI
acts upstream of or within positive regulation of developmental process	IMP IMP: Inferred from mutant phenotype	9988273	MGI
acts upstream of or within positive regulation of epithelial cell apoptotic process	IMP IMP: Inferred from mutant phenotype	9988273	MGI
acts upstream of or within positive regulation of intrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	14502238	MGI
acts upstream of or within positive regulation of mitochondrial membrane permeability involved in apoptotic process	IGI IGI: Inferred from genetic interaction	15967824	MGI
acts upstream of or within positive regulation of motor neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	15944391	MGI
acts upstream of or within positive regulation of neuron apoptotic process	IGI IGI: Inferred from genetic interaction	9096145	MGI
acts upstream of or within positive regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	8816704	MGI
involved in positive regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	27098698	MGI
acts upstream of or within positive regulation of release of sequestered calcium ion into cytosol	IMP IMP: Inferred from mutant phenotype	15947791	MGI
acts upstream of or within positive regulation of reproductive process	IMP IMP: Inferred from mutant phenotype	9988273	MGI
acts upstream of or within post-embryonic camera-type eye morphogenesis	IGI IGI: Inferred from genetic interaction	15955981	MGI
acts upstream of or within post-embryonic development	IGI IGI: Inferred from genetic interaction	9241272	MGI
acts upstream of or within protein insertion into mitochondrial membrane	IMP IMP: Inferred from mutant phenotype	12952892	MGI
involved in regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	33712461	MGI
acts upstream of or within regulation of cell cycle	IGI IGI: Inferred from genetic interaction	16055554	MGI
acts upstream of or within regulation of cysteine-type endopeptidase activity involved in apoptotic process	IMP IMP: Inferred from mutant phenotype	14507967	MGI
acts upstream of or within regulation of mammary gland epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	10363969	MGI
acts upstream of or within regulation of mitochondrial membrane permeability involved in apoptotic process	IGI IGI: Inferred from genetic interaction	14963330	MGI
acts upstream of or within regulation of mitochondrial membrane permeability involved in programmed necrotic cell death	IMP IMP: Inferred from mutant phenotype	22493254	MGI
NOT acts upstream of or within regulation of mitochondrial membrane potential	IDA IDA: Inferred from direct assay	14614769	MGI
acts upstream of or within regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	19029045	MGI
acts upstream of or within regulation of nitrogen utilization	IGI IGI: Inferred from genetic interaction	9241272	MGI
acts upstream of or within release of cytochrome c from mitochondria	IDA IDA: Inferred from direct assay	9560217	MGI
acts upstream of or within release of cytochrome c from mitochondria	IGI IGI: Inferred from genetic interaction	14963330	MGI
acts upstream of release of sequestered calcium ion into cytosol	IMP IMP: Inferred from mutant phenotype	15947791	MGI
acts upstream of or within response to axon injury	IMP IMP: Inferred from mutant phenotype	16103918	MGI
acts upstream of or within response to gamma radiation	IMP IMP: Inferred from mutant phenotype	17068116	MGI
acts upstream of or within response to ionizing radiation	IGI IGI: Inferred from genetic interaction	10639175	MGI
acts upstream of or within response to ionizing radiation	IMP IMP: Inferred from mutant phenotype	15578100	MGI
acts upstream of or within response to salt stress	IGI IGI: Inferred from genetic interaction	16571598	MGI
acts upstream of or within response to toxic substance	IMP IMP: Inferred from mutant phenotype	9454845	MGI
acts upstream of or within response to wounding	IMP IMP: Inferred from mutant phenotype	14507967	MGI
acts upstream of or within retina development in camera-type eye	IMP IMP: Inferred from mutant phenotype	9699561	MGI
acts upstream of or within retinal cell programmed cell death	IMP IMP: Inferred from mutant phenotype	14517994	MGI
acts upstream of or within sex differentiation	IMP IMP: Inferred from mutant phenotype	15342910	MGI
acts upstream of or within spermatid differentiation	IMP IMP: Inferred from mutant phenotype	16270031	MGI
acts upstream of or within spermatogenesis	IGI IGI: Inferred from genetic interaction	10894153	MGI
acts upstream of or within spermatogenesis	IMP IMP: Inferred from mutant phenotype	7569956	MGI
acts upstream of or within thymocyte apoptotic process	IGI IGI: Inferred from genetic interaction	15967824	MGI
acts upstream of or within vagina development	IGI IGI: Inferred from genetic interaction	11163212	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of BAX complex	IPI IPI: Inferred from physical interaction	11060313	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	10464378	MGI
located in cytosol	IDA IDA: Inferred from direct assay	9553144	MGI
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	12847083	MGI
located in intracellular anatomical structure	IDA IDA: Inferred from direct assay	9008714	MGI
located in mitochondrial membrane	IDA IDA: Inferred from direct assay	11369777	MGI
located in mitochondrial outer membrane	IDA IDA: Inferred from direct assay	12910269	MGI
located in mitochondrion	IDA IDA: Inferred from direct assay	11369777	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Bax Protein Structure

bcl-2

0
100
192 a.a.

Protein Preferred Names

Protein Names

apoptosis regulator BAX

Related Agents

Approval

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0402	Amantadine	Modulator	99.90%	Yes
HY-B1192	Estradiol benzoate		99.89%	Unkown
HY-B1357	Digitoxin		99.36%	Yes
HY-B0402A	Amantadine hydrochloride	Modulator	≥98.0%	Yes
HY-B0621	Triclabendazole		98.72%	Yes
HY-B0402B	Amantadine sulfate	Modulator	/	Unkown

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-13755	Sulforaphane	Inhibitor	99.75%	Phase 4
HY-13560	AVN-944	Modulator	99.77%	Phase 2

Pre-clinical Phase

Bioactive Molecules (50)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-107202	Polyinosinic-polycytidylic acid		99.40%	Unkown
HY-13594	Chlorin e6		98.31%	Unkown
HY-103269	BAI1	Inhibitor	99.89%	Unkown
HY-N0674	Dehydrocorydaline	Modulator	99.77%	Unkown
HY-P0081	Bax inhibitor peptide V5	Inhibitor	99.77%	Unkown
HY-N0361	Dihydrocapsaicin	Modulator	99.86%	Unkown
HY-123054	BTSA1	Activator	99.49%	Unkown
HY-120079	MSN-125	Inhibitor	99.00%	Unkown
HY-13108	Bz 423	Activator	99.72%	Unkown
HY-B1971	Deltamethrin		99.93%	Unkown
HY-13755A	(R)-Sulforaphane	Inhibitor	99.48%	Unkown
HY-N0060B	(E)-Ferulic acid	Activator	99.89%	Unkown
HY-N6626	Pyraclostrobin		99.91%	Unkown
HY-P1928	Humanin	Inhibitor	99.83%	Unkown
HY-N0831	Jaceosidin	Activator	99.51%	Unkown
HY-W082785A	L6H21	Modulator	99.46%	Unkown
HY-118948	MSN-50	Inhibitor	98.68%	Unkown
HY-15341	BAM7	Activator	98.53%	Unkown
HY-157176	BAX-IN-1	Inhibitor	≥98.0%	Unkown
HY-108164	Aspidin BB	Modulator	98.08%	Unkown
HY-132173	GL0388	Activator	98.01%	Unkown
HY-122760	Bax activator-1	Activator	98.45%	Unkown
HY-N1157	Thevetiaflavone	Modulator	≥98.0%	Unkown
HY-N9802	n-Butyl-β-D-fructofuranoside	Activator	≥97.0%	Unkown
HY-147889	BBR-BODIPY	Activator	98.15%	Unkown
HY-N0905	Ginsenoside Rh4	Activator	99.28%	Unkown
HY-146253	CDK1/2/4-IN-1	Activator	/	Unkown
HY-N0831R	Jaceosidin (Standard)	Activator	/	Unkown
HY-144792	Bcl-2-IN-7	Modulator	/	Unkown
HY-101996	SMBA1	Agonist	/	Unkown
HY-143235	BRD4 Inhibitor-15	Modulator	/	Unkown
HY-N10481	Aviculin	Modulator	/	Unkown
HY-146548	Anticancer agent 43	Inducer	98.58%	Unkown
HY-148368	CYD-4-61	Activator	/	Unkown
HY-146105	Anticancer agent 65	Modulator	/	Unkown
HY-N10313	Dehydrobruceine B	Modulator	/	Unkown
HY-161659	Apoptosis inducer 19	Modulator	/	Unkown
HY-162360	EGFR-IN-109	Inhibitor	/	Unkown
HY-P3148	Astin B	Modulator	/	Unkown
HY-147928	Apoptotic agent-2	Activator	/	Unkown
HY-151428	Antitumor agent-78	Inhibitor	/	Unkown
HY-117652	Lobetyol	Modulator	/	Unkown
HY-168623	EGFR-IN-134	Inhibitor	/	Unkown
HY-144791	Bcl-2-IN-6	Modulator	/	Unkown
HY-151429	Antitumor agent-77	Inhibitor	/	Unkown
HY-147929	Apoptotic agent-3	Activator	/	Unkown
HY-147514	Anticancer agent 64	Modulator	/	Unkown
HY-150540	Bcl-2-IN-10	Inhibitor	/	Unkown
HY-119682	Bax agonist 1		/	Unkown
HY-122481	Thaspine acetate		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Bax	NCBI	NCBI:581

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