Mmp2 - matrix metallopeptidase 2 Gene

Mus musculus

Also known as GelA; Clg4a; MMP-2

Gene ID: 17390 | Gene type: protein coding

About Mmp2

Chromosome 8: 93,553,919-93,580,048 forward strand.GRCm39:CM001001.3

This gene has 4 transcripts (splice variants), 210 orthologues, 23 paralogues and is associated with 73 phenotypes. Broad expression in mammary gland adult (RPKM 186.), subcutaneous fat pad adult (RPKM 13.) and 15 other tissues.

Summary

This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading Enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded preproprotein undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase Enzyme that hydrolyzes collagens, gelatins, laminin, fibronectin and elastin. Mice lacking the encoded protein exhibit suppressed angiogenesis and attenuated features of human multicentric osteolysis with arthritis including abnormal skeletal and craniofacial development. [provided by RefSeq, Feb 2016]

Mmp2 Products(1)

mRNA	Protein	Name
NM_008610.3	NP_032636.1	72 kDa type IV collagenase preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables metalloendopeptidase activity	IDA IDA: Inferred from direct assay	12419962	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within blood vessel maturation	IGI IGI: Inferred from genetic interaction	11747814	MGI
acts upstream of or within bone trabecula formation	IGI IGI: Inferred from genetic interaction	17440987	MGI
acts upstream of or within cellular response to amino acid stimulus	IDA IDA: Inferred from direct assay	20548288	MGI
acts upstream of or within cellular response to reactive oxygen species	IMP IMP: Inferred from mutant phenotype	17561096	MGI
acts upstream of or within collagen catabolic process	IMP IMP: Inferred from mutant phenotype	17440987	MGI
acts upstream of or within embryo implantation	IDA IDA: Inferred from direct assay	18556655	MGI
acts upstream of or within face morphogenesis	IGI IGI: Inferred from genetic interaction	17440987	MGI
acts upstream of or within intramembranous ossification	IGI IGI: Inferred from genetic interaction	17440987	MGI
acts upstream of or within positive regulation of smooth muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	17561096	MGI
involved in response to amyloid-beta	IDA IDA: Inferred from direct assay	28912710	MGI
acts upstream of or within response to hypoxia	IDA IDA: Inferred from direct assay	17382917	MGI
acts upstream of or within skeletal system morphogenesis	IGI IGI: Inferred from genetic interaction	17440987	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	17349656	MGI
located in sarcomere	IDA IDA: Inferred from direct assay	17349656	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Mmp2 Protein Structure

PG_binding_1

Peptidase_M10

FN2

0
200
400
600
662 a.a.

Protein Preferred Names

Protein Names

72 kDa type IV collagenase

72 kDa gelatinase	72kD gelatinase
72kD type IV collagenase	72kDa gelatinase
72kDa type IV collagenase	gelatinase A
matrix metalloproteinase 2

Recombinant Mmp2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73810	MMP-2 Protein, Mouse (HEK293, His)	NP_032636.1 (M409-C662)	≥95%

Related Agents

Approval

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0689A	Indinavir sulfate		99.97%	Yes
HY-B0493	Niflumic acid	Inhibitor	99.88%	Unkown
HY-B0689	Indinavir		/	Unkown
HY-B0689B	Indinavir sulfate ethanolate		/	Unkown

Clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Phase
HY-12169	Marimastat	Inhibitor	99.81%	Phase 3
HY-12170	Prinomastat		99.27%	Phase 3
HY-12170A	Prinomastat hydrochloride		98.18%	Phase 3
HY-15768	Ilomastat	Inhibitor	98.39%	Phase 2
HY-10398	CTS-1027	Inhibitor	99.19%	Phase 2
HY-106992	S 3304	Inhibitor	99.11%	Phase 2
HY-19485	XL-784	Inhibitor	98.13%	Phase 2
HY-112160	XL-784 free base	Inhibitor	/	Phase 2

Pre-clinical Phase

Bioactive Molecules (87)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N0431	Astragaloside IV	Inhibitor	99.93%	Unkown
HY-122022	JR-AB2-011	Inhibitor	99.16%	Unkown
HY-13564	Batimastat	Inhibitor	98.92%	Unkown
HY-12354	SB-3CT	Inhibitor	99.59%	Unkown
HY-122214	AC-73	Inducer	99.89%	Unkown
HY-110397	KP-457	Inhibitor	99.18%	Unkown
HY-103444	ARP-100	Inhibitor	≥99.0%	Unkown
HY-N0069	Solamargine		99.97%	Unkown
HY-W068119A	N-(2-Aminoethyl)maleimide hydrochloride		99.97%	Unkown
HY-N0532	Morroniside	Inhibitor	99.88%	Unkown
HY-107394	UK 356618	Inhibitor	98.91%	Unkown
HY-N0084	Betulinaldehyde	Inhibitor	98.72%	Unkown
HY-107428	PD-166793	Inhibitor	99.45%	Unkown
HY-131498	MOCAc-PLGL(Dpa)AR		99.86%	Unkown
HY-P3513	β-Neo-Endorphin	Activator	98.22%	Unkown
HY-112546	MMP-2 Inhibitor I	Inhibitor	99.23%	Unkown
HY-120213	YH-306		98.01%	Unkown
HY-P0273A	Histatin 5 TFA	Inhibitor	99.98%	Unkown
HY-107639	UK-370106	Inhibitor	≥99.0%	Unkown
HY-124373	ND-336	Inhibitor	95.4%	Unkown
HY-101535	ARP101	Inhibitor	99.39%	Unkown
HY-116399	MMP-2/MMP-9-IN-1	Inhibitor	99.25%	Unkown
HY-117970	MMPI-1154	Inhibitor	99.87%	Unkown
HY-12168	Tanomastat	Inhibitor	99.5%	Unkown
HY-122506	Salviolone	Inhibitor	99.61%	Unkown
HY-146754	MMP2-IN-1		99.18%	Unkown
HY-147746	MMP2-IN-3	Inhibitor	99.64%	Unkown
HY-148571	TP0597850	Inhibitor	99.09%	Unkown
HY-114911	Feprazone	Inhibitor	99.88%	Unkown
HY-147031	JAMM protein inhibitor 2	Inhibitor	98.20%	Unkown
HY-147745	MMP2-IN-2	Inhibitor	98.80%	Unkown
HY-P2213A	GPLGIAGQ TFA	Inducer	98.40%	Unkown
HY-W001925	7-Methoxy-1-tetralone		99.93%	Unkown
HY-110116	SD-2590 hydrochloride	Inhibitor	99.1%	Unkown
HY-131417	cis-ACCP	Inhibitor	≥97.0%	Unkown
HY-14240	PG 116800	Inhibitor	/	Unkown
HY-N5136	25(R,S)-Ruscogenin	Inhibitor	99.83%	Unkown
HY-P1789A	CTTHWGFTLC, CYCLIC TFA	Inhibitor	98.91%	Unkown
HY-W011085	CP-471474	Inhibitor	99.2%	Unkown
HY-77813S	Benzyl isothiocyanate-d7		/	Unkown
HY-110397G	KP-457 (GMP)	Inhibitor	/	Unkown
HY-111172	Inotilone	Inhibitor	/	Unkown
HY-114396	BR351	Inhibitor	/	Unkown
HY-114785	BPHA	Inhibitor	/	Unkown
HY-120349	LL-Z1640-4	Inhibitor	/	Unkown
HY-12168B	(Rac)-Tanomastat	Inhibitor	/	Unkown
HY-124373A	(R)-ND-336	Inhibitor	/	Unkown
HY-130076	MMP-2 Inhibitor II	Inhibitor	/	Unkown
HY-136699	Excisanin A		/	Unkown
HY-143407	FAK-IN-3	Inhibitor	/	Unkown
HY-147867	MMP-2/9-IN-1	Inhibitor	/	Unkown
HY-147936	TP0556351	Inhibitor	/	Unkown
HY-149378	MMP13-IN-5	Inhibitor	/	Unkown
HY-152030	Tubulin/MMP-IN-2		/	Unkown
HY-154698	Homouridine		/	Unkown
HY-155201	YJ182	Inhibitor	/	Unkown
HY-155721	22-(4′-py)-JA	Inhibitor	/	Unkown
HY-156247	IVMT-Rx-3	Inhibitor	/	Unkown
HY-157382	AChE-IN-51	Inhibitor	/	Unkown
HY-161707	MMP2-IN-4	Inhibitor	/	Unkown
HY-162038	RXP03	Inhibitor	/	Unkown
HY-162344	Ir-CA	Inducer	/	Unkown
HY-164525	SD-7300	Inhibitor	/	Unkown
HY-168560	MMP Inhibitor 4	Inhibitor	/	Unkown
HY-168605	DH-18		/	Unkown
HY-N10176	D-Isofloridoside	Inhibitor	/	Unkown
HY-N7385	Nudol		/	Unkown
HY-P1789	CTTHWGFTLC, CYCLIC	Inhibitor	/	Unkown
HY-P2213	GPLGIAGQ	Inducer	/	Unkown
HY-P3477	Mca-PLA-Nva-Dap(Dnp)-AR-NH2		/	Unkown
HY-P3513A	β-Neo-Endorphin acetate	Activator	/	Unkown
HY-P4574	VPLSLYSG		/	Unkown
HY-P5380	TNO211		/	Unkown
HY-RS08537	MMP2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS08538	Mmp2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS08539	Mmp2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-W277900	2-Methoxy-2,4-diphenylfuran-3-one		/	Unkown
HY-119110	LY52	Inhibitor	/	Unkown
HY-119185	AZD-6605		/	Unkown
HY-123130	ABT-770	Inhibitor	/	Unkown
HY-124341	ND-378	Inhibitor	/	Unkown
HY-13564A	Batimastat sodium salt	Inhibitor	/	Unkown
HY-18694	CGS 27023A	Inhibitor	/	Unkown
HY-35513	3-Aminobenzene-1,2-diol	Inhibitor	/	Unkown
HY-43586	BR351 precursor	Inhibitor	/	Unkown
HY-N13208	Stevia Powder		/	Unkown
HY-P0273	Histatin 5	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Mmp2	NCBI	NCBI:4313
Rattus norvegicus	Mmp2	NCBI	NCBI:81686

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