Mmp2 - matrix metallopeptidase 2 Gene

Rattus norvegicus

Gene ID: 81686 | Gene type: protein coding

About Mmp2

Primary_assembly 19: 14,154,657-14,182,870 reverse strand.mRatBN7.2:CM026992.1

This gene has 2 transcripts (splice variants), 210 orthologues, 23 paralogues and is associated with 166 phenotypes. Biased expression in Uterus (RPKM 651.), Lung (RPKM 536.) and 8 other tissues.

Summary

Enables fibronectin binding activity and peptidase activity. Involved in several processes, including cellular response to estradiol stimulus; circulatory system development; and reproductive structure development. Located in cytoplasm and extracellular space. Used to study artery disease (multiple); conjunctivitis; and transient cerebral ischemia. Biomarker of several diseases, including acute necrotizing pancreatitis; artery disease (multiple); bile duct disease (multiple); brain ischemia (multiple); and liver cirrhosis (multiple). Human ortholog(s) of this gene implicated in artery disease (multiple); eye disease (multiple); pseudoxanthoma elasticum; and temporal arteritis. Orthologous to human MMP2 (matrix metallopeptidase 2). [provided by Alliance of Genome Resources, Apr 2022]

Mmp2 Products(1)

mRNA	Protein	Name
NM_031054.2	NP_112316.2	72 kDa type IV collagenase precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables fibronectin binding	IPI IPI: Inferred from physical interaction	18039280	RGD
enables peptidase activity	IDA IDA: Inferred from direct assay	8531210	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	28659595	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in angiogenesis	IEP IEP: Inferred from expression pattern	12234794	RGD
involved in cell migration	IMP IMP: Inferred from mutant phenotype	20371087	RGD
involved in cellular response to cytokine stimulus	IEP IEP: Inferred from expression pattern	19909738	RGD
involved in cellular response to estradiol stimulus	IMP IMP: Inferred from mutant phenotype	19861308	RGD
involved in cellular response to fluid shear stress	IEP IEP: Inferred from expression pattern	21637818	RGD
involved in cellular response to interleukin-1	IEP IEP: Inferred from expression pattern	16046515	RGD
involved in collagen catabolic process	IDA IDA: Inferred from direct assay	22410640	RGD
involved in female pregnancy	IEP IEP: Inferred from expression pattern	15044600	RGD
involved in heart development	IDA IDA: Inferred from direct assay	12061388	RGD
involved in luteinization	IEP IEP: Inferred from expression pattern	10537164	RGD
involved in macrophage chemotaxis	IDA IDA: Inferred from direct assay	20110414	RGD
involved in negative regulation of cell adhesion	IDA IDA: Inferred from direct assay	14645107	RGD
involved in negative regulation of vasoconstriction	IDA IDA: Inferred from direct assay	19482300	RGD
involved in ovarian follicle development	IDA IDA: Inferred from direct assay	15617683	RGD
involved in ovulation from ovarian follicle	IEP IEP: Inferred from expression pattern	14668206	RGD
involved in parturition	IEP IEP: Inferred from expression pattern	19923067	RGD
involved in peripheral nervous system axon regeneration	IDA IDA: Inferred from direct assay	15026117	RGD
involved in positive regulation of apoptotic process	IDA IDA: Inferred from direct assay	16857167	RGD
involved in positive regulation of cell migration	IMP IMP: Inferred from mutant phenotype	21637818	RGD
involved in positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	27614125	RGD
involved in prostate gland epithelium morphogenesis	IMP IMP: Inferred from mutant phenotype	20108352	RGD
involved in protein catabolic process	IDA IDA: Inferred from direct assay	16899336	RGD
involved in proteolysis	IDA IDA: Inferred from direct assay	20110414	RGD
involved in response to activity	IEP IEP: Inferred from expression pattern	19685505	RGD
involved in response to cytokine	IEP IEP: Inferred from expression pattern	17822627	RGD
involved in response to electrical stimulus	IEP IEP: Inferred from expression pattern	19660200	RGD
involved in response to estrogen	IDA IDA: Inferred from direct assay	16765374	RGD
involved in response to hydrogen peroxide	IDA IDA: Inferred from direct assay	16934674	RGD
involved in response to hyperoxia	IEP IEP: Inferred from expression pattern	19099751	RGD
involved in response to hypoxia	IDA IDA: Inferred from direct assay	16980344	RGD
involved in response to mechanical stimulus	IDA IDA: Inferred from direct assay	15350851	RGD
involved in response to nicotine	IEP IEP: Inferred from expression pattern	19879865	RGD
involved in response to oxidative stress	IDA IDA: Inferred from direct assay	15642321	RGD
involved in response to retinoic acid	IEP IEP: Inferred from expression pattern	19099751	RGD
involved in response to xenobiotic stimulus	IDA IDA: Inferred from direct assay	16846501	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	19874802	RGD
involved in tissue remodeling	IDA IDA: Inferred from direct assay	16740171	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	23911909	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Mmp2 Protein Structure

PG_binding_1

Peptidase_M10

FN2

0
200
400
600
662 a.a.

Protein Preferred Names

Protein Names

72 kDa type IV collagenase

72 kDa gelatinase	MMP-2
gelatinase A	matrix metalloproteinase-2

Recombinant Mmp2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P700573	MMP-2 Protein, Rat (P. pastoris, His)	P33436 (Y110-C662)	≥95%

Related Agents

Approval

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0689A	Indinavir sulfate		99.97%	Yes
HY-B0493	Niflumic acid	Inhibitor	99.88%	Unkown
HY-B0689	Indinavir		/	Unkown
HY-B0689B	Indinavir sulfate ethanolate		/	Unkown

Clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Phase
HY-12169	Marimastat	Inhibitor	99.81%	Phase 3
HY-12170	Prinomastat		99.27%	Phase 3
HY-12170A	Prinomastat hydrochloride		98.18%	Phase 3
HY-15768	Ilomastat	Inhibitor	98.39%	Phase 2
HY-10398	CTS-1027	Inhibitor	99.19%	Phase 2
HY-106992	S 3304	Inhibitor	99.11%	Phase 2
HY-19485	XL-784	Inhibitor	98.13%	Phase 2
HY-112160	XL-784 free base	Inhibitor	/	Phase 2

Pre-clinical Phase

Bioactive Molecules (87)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N0431	Astragaloside IV	Inhibitor	99.93%	Unkown
HY-122022	JR-AB2-011	Inhibitor	99.16%	Unkown
HY-13564	Batimastat	Inhibitor	98.92%	Unkown
HY-12354	SB-3CT	Inhibitor	99.59%	Unkown
HY-122214	AC-73	Inducer	99.89%	Unkown
HY-110397	KP-457	Inhibitor	99.18%	Unkown
HY-103444	ARP-100	Inhibitor	≥99.0%	Unkown
HY-N0069	Solamargine		99.97%	Unkown
HY-W068119A	N-(2-Aminoethyl)maleimide hydrochloride		99.97%	Unkown
HY-N0532	Morroniside	Inhibitor	99.88%	Unkown
HY-107394	UK 356618	Inhibitor	98.91%	Unkown
HY-N0084	Betulinaldehyde	Inhibitor	98.72%	Unkown
HY-107428	PD-166793	Inhibitor	99.45%	Unkown
HY-131498	MOCAc-PLGL(Dpa)AR		99.86%	Unkown
HY-P3513	β-Neo-Endorphin	Activator	98.22%	Unkown
HY-112546	MMP-2 Inhibitor I	Inhibitor	99.23%	Unkown
HY-120213	YH-306		98.01%	Unkown
HY-P0273A	Histatin 5 TFA	Inhibitor	99.98%	Unkown
HY-107639	UK-370106	Inhibitor	≥99.0%	Unkown
HY-124373	ND-336	Inhibitor	95.4%	Unkown
HY-101535	ARP101	Inhibitor	99.39%	Unkown
HY-116399	MMP-2/MMP-9-IN-1	Inhibitor	99.25%	Unkown
HY-117970	MMPI-1154	Inhibitor	99.87%	Unkown
HY-12168	Tanomastat	Inhibitor	99.5%	Unkown
HY-122506	Salviolone	Inhibitor	99.61%	Unkown
HY-146754	MMP2-IN-1		99.18%	Unkown
HY-147746	MMP2-IN-3	Inhibitor	99.64%	Unkown
HY-148571	TP0597850	Inhibitor	99.09%	Unkown
HY-114911	Feprazone	Inhibitor	99.88%	Unkown
HY-147031	JAMM protein inhibitor 2	Inhibitor	98.20%	Unkown
HY-147745	MMP2-IN-2	Inhibitor	98.80%	Unkown
HY-P2213A	GPLGIAGQ TFA	Inducer	98.40%	Unkown
HY-W001925	7-Methoxy-1-tetralone		99.93%	Unkown
HY-110116	SD-2590 hydrochloride	Inhibitor	99.1%	Unkown
HY-131417	cis-ACCP	Inhibitor	≥97.0%	Unkown
HY-14240	PG 116800	Inhibitor	99.81%	Unkown
HY-N5136	25(R,S)-Ruscogenin	Inhibitor	99.83%	Unkown
HY-P1789A	CTTHWGFTLC, CYCLIC TFA	Inhibitor	98.91%	Unkown
HY-W011085	CP-471474	Inhibitor	99.2%	Unkown
HY-77813S	Benzyl isothiocyanate-d7		/	Unkown
HY-110397G	KP-457 (GMP)	Inhibitor	/	Unkown
HY-111172	Inotilone	Inhibitor	/	Unkown
HY-114396	BR351	Inhibitor	/	Unkown
HY-114785	BPHA	Inhibitor	/	Unkown
HY-120349	LL-Z1640-4	Inhibitor	/	Unkown
HY-12168B	(Rac)-Tanomastat	Inhibitor	/	Unkown
HY-124373A	(R)-ND-336	Inhibitor	/	Unkown
HY-130076	MMP-2 Inhibitor II	Inhibitor	/	Unkown
HY-136699	Excisanin A		/	Unkown
HY-143407	FAK-IN-3	Inhibitor	/	Unkown
HY-147867	MMP-2/9-IN-1	Inhibitor	/	Unkown
HY-147936	TP0556351	Inhibitor	/	Unkown
HY-149378	MMP13-IN-5	Inhibitor	/	Unkown
HY-152030	Tubulin/MMP-IN-2		/	Unkown
HY-154698	Homouridine		/	Unkown
HY-155201	YJ182	Inhibitor	/	Unkown
HY-155721	22-(4′-py)-JA	Inhibitor	/	Unkown
HY-156247	IVMT-Rx-3	Inhibitor	/	Unkown
HY-157382	AChE-IN-51	Inhibitor	/	Unkown
HY-161707	MMP2-IN-4	Inhibitor	/	Unkown
HY-162038	RXP03	Inhibitor	/	Unkown
HY-162344	Ir-CA	Inducer	/	Unkown
HY-164525	SD-7300	Inhibitor	/	Unkown
HY-168560	MMP Inhibitor 4	Inhibitor	/	Unkown
HY-168605	DH-18		/	Unkown
HY-N10176	D-Isofloridoside	Inhibitor	/	Unkown
HY-N7385	Nudol		/	Unkown
HY-P1789	CTTHWGFTLC, CYCLIC	Inhibitor	/	Unkown
HY-P2213	GPLGIAGQ	Inducer	/	Unkown
HY-P3477	Mca-PLA-Nva-Dap(Dnp)-AR-NH2		/	Unkown
HY-P3513A	β-Neo-Endorphin acetate	Activator	/	Unkown
HY-P4574	VPLSLYSG		/	Unkown
HY-P5380	TNO211		/	Unkown
HY-RS08537	MMP2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS08538	Mmp2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS08539	Mmp2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-W277900	2-Methoxy-2,4-diphenylfuran-3-one		/	Unkown
HY-119110	LY52	Inhibitor	/	Unkown
HY-119185	AZD-6605		/	Unkown
HY-123130	ABT-770	Inhibitor	/	Unkown
HY-124341	ND-378	Inhibitor	/	Unkown
HY-13564A	Batimastat sodium salt	Inhibitor	/	Unkown
HY-18694	CGS 27023A	Inhibitor	/	Unkown
HY-35513	3-Aminobenzene-1,2-diol	Inhibitor	/	Unkown
HY-43586	BR351 precursor	Inhibitor	/	Unkown
HY-N13208	Stevia Powder		/	Unkown
HY-P0273	Histatin 5	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Mmp2	NCBI	NCBI:4313

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