LCK - LCK proto-oncogene, Src family tyrosine kinase Gene

Homo sapiens

Also known as LSK; YT16; IMD22; p56lck; pp58lck

Gene ID: 3932 | Gene type: protein coding

About LCK

Cytogenetic location: 1p35.2 Genomic coordinates (GRCh38): 1:32,251,265-32,286,165 (from NCBI)

This gene has 14 transcripts (splice variants), 120 orthologues, 32 paralogues and is associated with 67 phenotypes. Biased expression in lymph node (RPKM 46.5), appendix (RPKM 22.7) and 9 other tissues.

Summary

This gene is a member of the Src family of Protein Tyrosine Kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to the plasma membrane and pericentrosomal vesicles, and binds to cell surface receptors, including CD4 and CD8, and Other signaling molecules. Multiple alternatively spliced variants encoding different isoforms have been described. [provided by RefSeq, Aug 2016]

LCK Products(3)

mRNA	Protein	Name
NM_001042771.3	NP_001036236.1	tyrosine-protein kinase Lck isoform a
NM_001330468.2	NP_001317397.1	tyrosine-protein kinase Lck isoform b
NM_005356.5	NP_005347.3	tyrosine-protein kinase Lck isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATPase binding	IPI IPI: Inferred from physical interaction	15671290	GOA
enables CD4 receptor binding	IPI IPI: Inferred from physical interaction	7486703	GOA
enables CD8 receptor binding	IPI IPI: Inferred from physical interaction	2470098	GOA
enables SH2 domain binding	IPI IPI: Inferred from physical interaction	7852312	GOA
enables T cell receptor binding	IPI IPI: Inferred from physical interaction	8681956	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	17118402	GOA
enables non-membrane spanning protein tyrosine kinase activity	IDA IDA: Inferred from direct assay	8681956	GOA
enables phosphatidylinositol 3-kinase binding	IPI IPI: Inferred from physical interaction	7504174	GOA
enables phospholipase activator activity	IDA IDA: Inferred from direct assay	11606584	GOA
enables phospholipase binding	IPI IPI: Inferred from physical interaction	11606584	GOA
enables phosphotyrosine residue binding	IPI IPI: Inferred from physical interaction	20624904	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	7507203	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	8618896	GOA
enables protein phosphatase binding	IPI IPI: Inferred from physical interaction	22080863	GOA
enables protein serine/threonine phosphatase activity	IDA IDA: Inferred from direct assay	8506364	GOA
enables protein tyrosine kinase activity	EXP EXP: Inferred from Experiment	1381360	GOA
enables protein tyrosine kinase activity	IDA IDA: Inferred from direct assay	214242	GOA
enables protein tyrosine kinase activity	IMP IMP: Inferred from mutant phenotype	8681956	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in CD27 signaling pathway	IDA IDA: Inferred from direct assay	38354704	GOA
involved in Fc-gamma receptor signaling pathway	IDA IDA: Inferred from direct assay	8478617	GOA
involved in T cell activation	IDA IDA: Inferred from direct assay	38354704	GOA
involved in T cell differentiation	IMP IMP: Inferred from mutant phenotype	1579166	GOA
involved in T cell receptor signaling pathway	IDA IDA: Inferred from direct assay	8943371	GOA
involved in activation of cysteine-type endopeptidase activity involved in apoptotic process	IDA IDA: Inferred from direct assay	16116473	GOA
involved in intracellular signal transduction	IDA IDA: Inferred from direct assay	8681956	GOA
involved in intracellular zinc ion homeostasis	IEP IEP: Inferred from expression pattern	11739864	GOA
involved in peptidyl-tyrosine autophosphorylation	IDA IDA: Inferred from direct assay	8478617	GOA
involved in peptidyl-tyrosine phosphorylation	IMP IMP: Inferred from mutant phenotype	8681956	GOA
involved in positive regulation of T cell activation	IDA IDA: Inferred from direct assay	8943371	GOA
involved in positive regulation of heterotypic cell-cell adhesion	IMP IMP: Inferred from mutant phenotype	27400149	GOA
involved in positive regulation of intrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	16116473	GOA
involved in positive regulation of leukocyte cell-cell adhesion	IMP IMP: Inferred from mutant phenotype	27400149	GOA
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	214242	GOA
involved in response to xenobiotic stimulus	IDA IDA: Inferred from direct assay	16116473	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in immunological synapse	IDA IDA: Inferred from direct assay	20007709	GOA
located in membrane raft	IDA IDA: Inferred from direct assay	12150984	GOA
located in pericentriolar material	IDA IDA: Inferred from direct assay	7513706	GOA
is active in plasma membrane	IDA IDA: Inferred from direct assay	12218089	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	12150984	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LCK Protein Structure

SH3_1

SH2

Pkinase_Tyr

0
100
200
300
400
509 a.a.

Protein Preferred Names

Protein Names

tyrosine-protein kinase Lck

T-lymphocyte specific protein tyrosine kinase p56lck

LCK Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	LCK	P06239	CDKAL1	Homo sapiens	Q5VV42	Validated Y2H	25416956
Intra	LCK	P06239	CDKAL1	Homo sapiens	Q5VV42	Y2H Prey Pooling	25416956
Intra	LCK	P06239	MET	Homo sapiens	P08581	FPS	24728074
Intra	LCK	P06239	ZAP70	Homo sapiens	P43403	Anti Tag CoIP	10318843
Intra	LCK	P06239	LAT	Homo sapiens	O43561	Protein Kinase Assay	16938345
Intra	LCK	P06239	PTPRC	Homo sapiens	P08575	Phosphatase Assay	7507203
Intra	LCK	P06239	PTPRC	Homo sapiens	P08575	Anti Bait CoIP	7507203
Intra	LCK	P06239	PTPRC	Homo sapiens	P08575	Affinity Chrom	8576115
Intra	LCK	P06239	PTPRC	Homo sapiens	P08575	Phosphatase Assay	19167335
Intra	LCK	P06239	KHDRBS1	Homo sapiens	Q07666	Pull Down	7852312
Intra	LCK	P06239	KIT	Homo sapiens	P10721	FPS	24728074
Intra	LCK	P06239	THEMIS	Homo sapiens	Q8N1K5-1	Protein Kinase Assay	23460737
Intra	LCK	P06239	HSP90AA1	Homo sapiens	P07900	Anti Tag CoIP	31980649
Intra	LCK	P06239	HSP90AA1	Homo sapiens	P07900	Anti Bait CoIP	16888650
Intra	LCK	P06239	UBC	Homo sapiens	P0CG48	Pull Down	18539162
Intra	LCK	P06239	HSP90AB1	Homo sapiens	P08238	Anti Tag CoIP	31980649
Intra	LCK	P06239	HSP90AB1	Homo sapiens	P08238	Lumier	22939624
Intra	LCK	P06239	HSP90AB1	Homo sapiens	P08238	Anti Tag CoIP	22939624
Intra	LCK	P06239	CD4	Homo sapiens	P01730	Anti Bait CoIP	16888650
Intra	LCK	P06239	YWHAE	Homo sapiens	P62258	Crosslink	36931259
Intra	LCK	P06239	PRKCQ	Homo sapiens	Q04759	Anti Tag CoIP	21964608
Intra	LCK	P06239	SH2D2A	Homo sapiens	Q9NP31	Pull Down	16839418
Intra	LCK	P06239	SH2D2A	Homo sapiens	Q9NP31	Anti Tag CoIP	15827961
Intra	LCK	P06239	SH2D2A	Homo sapiens	Q9NP31	Pull Down	15827961
Intra	LCK	P06239	SH2D2A	Homo sapiens	Q9NP31	Anti Bait CoIP	16839418
Intra	LCK	P06239	NR3C1	Homo sapiens	P04150	Imaging	16888650
Intra	LCK	P06239	MED28	Homo sapiens	Q9H204	Y2H	10656681
Intra	LCK	P06239	MED28	Homo sapiens	Q9H204	Pull Down	16899217
Intra	LCK	P06239	GAB1	Homo sapiens	Q13480	FPS	24728074
Intra	LCK	P06239	AR	Homo sapiens	P10275	FPS	24728074
Intra	LCK	P06239	GATA3	Homo sapiens	P23771	Validated Y2H	26871637
Intra	LCK	P06239	GATA3	Homo sapiens	P23771	Y2H Array	26871637
Intra	LCK	P06239	GATA3	Homo sapiens	P23771	Y2H Prey Pooling	26871637
Intra	LCK	P06239	LZTS2	Homo sapiens	Q9BRK4	Y2H Prey Pooling	25416956
Cross	LCK	P06239	tio_athv3	Ateline herpesvirus 3	Q9YJQ8	Anti Tag CoIP	16051843
Intra	LCK	P06239	ADAM15	Homo sapiens	Q13444	Pull Down	11741929
Intra	LCK	P06239	PTPN6	Homo sapiens	P29350	Phosphatase Assay	19167335
Intra	LCK	P06239	SYK	Homo sapiens	P43405	Far-WB	8798676
Intra	LCK	P06239	SYK	Homo sapiens	P43405	Y2H	15536084
Intra	LCK	P06239	SYK	Homo sapiens	P43405	Y2H	8798676
Intra	LCK	P06239	SYK	Homo sapiens	P43405	CoIP	8621719
Intra	LCK	P06239	SYK	Homo sapiens	P43405	Pull Down	8798676
Intra	LCK	P06239	BCL3	Homo sapiens	P20749	Anti Bait CoIP	16099425
Intra	LCK	P06239	BCL3	Homo sapiens	P20749	Anti Tag CoIP	16099425
Cross	LCK	P06239	tip_shv2c	Saimiriine herpesvirus 2	P22575	Anti Bait CoIP	17005671
Cross	LCK	P06239	tip_shv2c	Saimiriine herpesvirus 2	P22575	NMR	15554700

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant LCK Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73269	Lck Protein, Human (sf9, GST)	P06239 (M1-P509)	≥95%

LCK Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80743	Lck Antibody (YA712)	WB	Human

Related Diseases

Diseases

Alias

Immunodeficiency 22

Severe Combined Immunodeficiency Due To Lck Deficiency	IMD22
Scid Due To Lck Deficiency	Scid Due To Lymphocyte-Specific Protein Tyrosine Kinase Deficiency
Severe Combined Immunodeficiency Due To Lymphocyte-Specific Protein Tyrosine Kinase Deficiency	Immunodeficiency, Type 22

T-Cell Acute Lymphoblastic Leukemia

T-Cell Leukemia	Acute T Cell Leukemia
Precursor T Lymphoblastic Leukemia	Precursor T-Lymphoblastic Lymphoma/Leukemia
T Acute Lymphoblastic Leukemia	T-Cell Acute Lymphocytic Leukaemia
T-Cell Lymphoblastic Leukemia/Lymphoma	Leukemia T-Cell
Leukemia, T-Cell	Leukemia, Acute, Lymphoblastic, T-Cell
Leukemia, T-Cell Acute Lymphoblastic	Leukemia, Acute T-Cell
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	Precursor T-Cell Lymphoblastic Lymphoma
Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma

Thymoma

Primary Thymic Epithelial Neoplasm	Primary Thymic Epithelial Tumor
Thymus Neoplasms

Immunodeficiency 17

IMD17	Cd3-Gamma Deficiency
Scid-Like Immunodeficiency, T Cell-Partial, B Cell-Positive, Nk Cell-Positive	Combined Immunodeficiency Due To Cd3gamma Deficiency
Immunodeficiency 17, Cd3 Gamma Deficient	Cd3gamma Deficiency
Immunodeficiency, Type 17

Lymphopenia

Lymphocytopenia

Cd45 Deficiency

Combined Immunodeficiency

Combined T Cell And B Cell Immunodeficiency	Congenital Combined Immunodeficiency
Syndrome With Combined Immunodeficiency	Combined T And B Cell Immunodeficiency
Combined Immunity Deficiency	Combined Immunodeficiency Syndrome
Combined T-Cell And B-Cell Immunodeficiency	Lymphopenic Agammaglobulinaemia

Common Variable Immunodeficiency

Cvid	Common Variable Agammaglobulinemia
Common Variable Immune Deficiency	Acquired Hypogammaglobulinemia
Hypogamma-Globulinemia, Acquired	Idiopathic Immunoglobulin Deficiency
Primary Antibody Deficiency	Primary Hypogammaglobulinemia
Acquired Agammaglobulinemia	Sporadic Hypogammaglobulinemia
Common Variable Hypogamma-Globulinemia	Immunoglobulin Deficiency, Late-Onset
Common Variable Hypogammaglobulinemia	Immunodeficiency, Common Variable

Severe Combined Immunodeficiency

Scid	Severe Combined Immunodeficiency Disease
Combined T And B Cell Inborn Immunodeficiency	Immunodeficiency, Severe Combined
Scid - [Severe Combined Immunodeficiencies]

Autoimmune Disease

Autoimmune Diseases	Autoimmune Hypersensitivity Disease
Hypersensitivity Reaction Type Ii Disease	Type Ii Hypersensitivity Reaction Disease

Immunodeficiency 13

Idiopathic Cd4 Lymphopenia	IMD13
Icl	Immunodeficiency, Type 13

Immune Deficiency Disease

Immunodeficiency	Primary Immunodeficiency
Primary Immunodeficiency Disease	Immunologic Deficiency Syndromes
Hypoimmunity	Immune Deficiency Disorder
Immunodeficiency Syndrome	Immune Disorder
Primary Immune Deficiency Disorder	Immune System Diseases
Human Immunodeficiency Virus Infection	Hiv - [Human Immunodeficiency Virus Infection]
Hiv Positive Nos	Hiv Disease
Acquired Immune Deficiency Syndrome-Related Complex	Aids-Like Syndrome
Aids-Related Complex Nos	Arc - [Aids-Related Complex]
Immunodeficiency Due To Human Immunodeficiency Virus Infection	Unspecified Human Immunodeficiency Virus Disease
Hiv Disease Nos	Human Immunodeficiency Virus Positive Nos
Hiv Nos	Deficiency Of Complement Initial Pathway
Deficiency Of Complement Terminal Pathway	Cfdd - [Complement Factor D Deficiency]
Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency	Nonfamilial Hypogammaglobulinaemia
Common Variable Immune Deficiency	Nonfamilial Agammaglobulinaemia
Common Variable Agammaglobulinaemia	Agammaglobulinaemia Nos
Agammaglobulinaemia Antibody Deficiency Syndrome	Hypogammaglobulinaemia Antibody Deficiency Syndrome
Acquired Agammaglobulinaemia Nos	Hypogammaglobulinaemia Nos
Hyper Igm

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Thrombocytopenia

Low Platelet Count	Low Platelets
Decreased Platelets	Platelet Dysfunction Nos

Thymus Gland Disease

Disease Of Thymus Gland

Thymus Cancer

Thymic Neoplasm	Thymic Tumor
Thymus Neoplasm	Thymus Neoplasms
Malignant Neoplasm Of Thymus	Neoplasm Of Thymus
Thymic Neoplasms	Thymoma, Familial
Thymic Carcinoma	Thymoma, Type C
Cancer Of Thymus	Malignant Tumour Of Thymus
Primary Malignant Neoplasm Of Thymus	Thymic Glandular Cancer
Thymus Gland Cancer

Asthma

Chronic Obstructive Asthma	Asthma, Diminished Response To Antileukotriene Treatment In
Bronchial Hyperreactivity	Asthma, Susceptibility To
Asthma, Bronchial	Asthma, Protection Against
Asthma, Nocturnal, Susceptibility To	Nocturnal Asthma
Asthma-Related Traits	Asthma-Related Traits, Susceptibility To
Asthma, Nocturnal	Chronic Obstructive Asthma With Acute Exacerbation
Chronic Obstructive Asthma With Status Asthmaticus	Exercise Induced Asthma
Exercise-Induced Asthma	Bronchial Asthma
Asthma, Exercise-Induced	Idiosyncratic Asthma
Unspecified Asthma With Acute Exacerbation	Asthma, Unspecified, With Stated Status Asthmaticus
Status Asthmaticus Nos	Acute Severe Asthma
Acute Severe Bronchial Asthma	Status Asthma
Status Post Asthmaticus

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Complement Component 7 Deficiency

C7 Deficiency

C7D

Lymphoma, Non-Hodgkin, Familial

Non-Hodgkin Lymphoma	Lymphoma, Non-Hodgkin
NHL	Lymphoma, Non-Hodgkin, Somatic
Lymphoma, Follicular, Somatic	Familial Non-Hodgkin Lymphoma
Lymphoma Non-Hodgkins	Follicular Lymphoma, Somatic
Lymphosarcoma	Non-Hodgkins Lymphoma

Co-Trimoxazole Allergy

Bactrim Allergy	Cotrimoxazol Allergy
Tmp/Smx Allergy	Trimethoprim/Sulfamethoxazole Allergy

Epidermodysplasia Verruciformis 1

Epidermodysplasia Verruciformis	Epidermodysplasia Verruciformis, Susceptibility To, 1
Lutz-Lewandowsky Epidermodysplasia Verruciformis	EV1
Lewandowsky-Lutz Syndrome	Ev

Leukemia, Chronic Lymphocytic

Chronic Lymphocytic Leukemia	B-Cell Chronic Lymphocytic Leukemia
CLL	B-Cell Chronic Lymphoid Leukemia
Chronic Lymphatic Leukemia	Chronic Lymphocytic Leukaemia
Lymphoplasmacytic Leukemia	Small Lymphocytic Lymphoma
Leukemia, Chronic Lymphatic	B-Cell Chronic Lymphocytic Leukaemia
Chronic Lymphatic Leukaemia	Lymphoplasmacytic Leukaemia
B Cell Chronic Lymphocytic Leukemia	Chronic B-Cell Lymphocytic Leukemia
Leukemia, Lymphocytic, Chronic	B-Cll
Chronic Lymphoid Leukemia	Leukemia Lymphocytic Chronic
Lymphoma Small Lymphocytic	Leukemia, Lymphocytic, Chronic, B-Cell

Leukemia, Acute Myeloid

Acute Myeloid Leukemia	Leukemia, Acute Myelogenous
Acute Myelogenous Leukemia	AML
Leukemia, Acute Myeloid, Susceptibility To	Acute Myeloblastic Leukemia
Leukemia, Acute Myeloid, Reduced Survival In, Somatic	Acute Myeloid Leukaemia
Leukemia, Myelocytic, Acute	Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome
Secondary Aml	Acute Myelocytic Leukemia
Acute Myeloid Leukemia, Somatic	Leukemia, Acute Myeloid, Somatic
Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic	Acute Myeloblastic Leukaemia
Acute Myelogenous Leukaemia	Aml - Acute Myeloid Leukemia
Acute Myeloid Leukemia With Cebpa Somatic Mutations	Aml With Cebpa Somatic Mutations
Inherited Acute Myeloid Leukemia	Familial Aml
Inherited Aml	Pure Familial Aml
Pure Familial Acute Myeloid Leukemia	Secondary Acute Myeloid Leukemia
Therapy-Related Aml And Myelodysplastic Syndrome	Acute Myeloid Leukemia, Secondary
Acute Non-Lymphoblastic Leukemia	Acute Non-Lymphocytic Leukemia
Acute Biphenotypic Leukemia	Acute Undifferentiated Leukemia
Acute Myeloblastic Leukaemia With Multilineage Dysplasia	Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission
Acute Myeloid Leukaemia With Myelodysplasia-Related Features

Dilated Cardiomyopathy

Familial Dilated Cardiomyopathy	Primary Dilated Cardiomyopathy
Idiopathic Dilated Cardiomyopathy	Congestive Cardiomyopathy
Idiopathic Dilation Cardiomyopathy	Primary Familial Dilated Cardiomyopathy
Cardiomyopathy, Dilated	DCM
Cardiomyopathy, Familial Dilated	Dilated Cardiomyopathy, Familial
Hypokinetic Dilated Cardiomyopathy, Familial	Familial Idiopathic Cardiomyopathy
Fdc	Cardiomyopathy, Familial Idiopathic
Idiopathic Cardiomegaly	Dilated Congestive Cardiomyopathy
Chronic Dilated Cardiomyopathy	Ccm - [Congestive Cardiomyopathy]
Cocm - [Congestive Cardiomyopathy]	Dcm - [Dilated Cardiomyopathy]
Dilated-Hypokinetic Cardiomyopathy	Congestive Idiopathic Cardiomyopathy
Primary Idiopathic Dilated Cardiomyopathy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-15323	PRT062607 Hydrochloride	Inhibitor	98.07%	Phase 2

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15324	PRT062607 acetate	Inhibitor	99.83%	Unkown
HY-112291	SB 220025	Inhibitor	99.90%	Unkown
HY-118105	RK-20448	Inhibitor	99.38%	Unkown
HY-163278	Lck-IN-2	Inhibitor	/	Unkown
HY-120622	BMS-243117	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	LCK	VGNC	VGNC:99997
Mus musculus	LCK	MGD	MGI:96756
Canis familiaris	LCK	VGNC	VGNC:42607
Felis catus	LCK	VGNC	VGNC:68023
Rattus norvegicus	LCK	RGD	RGD:2994
Bos taurus	LCK	VGNC	VGNC:30810
Others	LCK	NCBI