MDM4 - MDM4 regulator of p53 Gene

Homo sapiens

Also known as HDMX; MDMX; MRP1; BMFS6

Gene ID: 4194 | Gene type: protein coding

About MDM4

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:204,516,406-204,558,120 (from NCBI)

This gene has 16 transcripts (splice variants), 218 orthologues, 1 paralogue and is associated with 75 phenotypes. Ubiquitous expression in bone marrow (RPKM 9.7), skin (RPKM 6.5) and 24 other tissues.

Summary

This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation domain. This protein also interacts with MDM2 protein via the RING finger domain, and inhibits the latter's degradation. So this protein can reverse MDM2-targeted degradation of p53, while maintaining suppression of p53 transactivation and apoptotic functions. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Feb 2011]

MDM4 Products(7)

mRNA	Protein	Name
NM_001204171.2	NP_001191100.1	protein Mdm4 isoform 2
NM_001204172.2	NP_001191101.1	protein Mdm4 isoform 3
NM_001278516.2	NP_001265445.1	protein Mdm4 isoform 4
NM_001278517.2	NP_001265446.1	protein Mdm4 isoform 5
NM_001278518.2	NP_001265447.1	protein Mdm4 isoform 6
NM_001278519.2	NP_001265448.1	protein Mdm4 isoform 7
NM_002393.5	NP_002384.2	protein Mdm4 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables enzyme binding	IPI IPI: Inferred from physical interaction	19838211	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10469568	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA damage response, signal transduction by p53 class mediator	IEP IEP: Inferred from expression pattern	14660608	GOA
involved in cellular response to hypoxia	IEP IEP: Inferred from expression pattern	20810912	GOA
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	9271120	GOA
involved in negative regulation of protein catabolic process	IMP IMP: Inferred from mutant phenotype	10608892	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	9226370	GOA
involved in protein stabilization	IEP IEP: Inferred from expression pattern	10608892	GOA
involved in protein-containing complex assembly	IDA IDA: Inferred from direct assay	10608892	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of transcription repressor complex	IPI IPI: Inferred from physical interaction	8875929	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MDM4 Protein Structure

SWIB

zf-RanBP

zf-C3HC4_3

0
100
200
300
400
490 a.a.

Protein Preferred Names

Protein Names

protein Mdm4

MDM4, p53 regulator

Recombinant MDM4 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74756	MDM4/MDMX Protein, Human (His)	O15151-1/NP_002384.2 (M1-D134)	≥95%

Related Diseases

Diseases

Alias

Bone Marrow Failure Syndrome 6

BMFS6

Intraocular Retinoblastoma

Pediatric Intraocular Retinoblastoma

Retinoblastoma

RB	Trilateral Retinoblastoma
RB1	Retinoblastoma, Trilateral
Neuroblastoma Of Retina	Rb - Retinoblastoma
Eye Cancer, Retinoblastoma	Retinal Cancer
Retinal Tumor	Glioma, Retinal
Non-Hereditary Retinoblastoma	Childhood Cancer Retinoblastoma
Malignant Neoplasm Of Retina	Retinal Neoplasms

Extraocular Retinoblastoma

Pediatric Extraocular Retinoblastoma

Bilateral Retinoblastoma

Unilateral Retinoblastoma

Leukocoria

Leucocoria

Glioblastoma

Glioblastoma Multiforme	Gbm
Adult Glioblastoma Multiforme	Grade Iv Adult Astrocytic Tumor
Primary Glioblastoma Multiforme	Spongioblastoma Multiforme
Adult Glioblastoma	Primary Glioblastoma

Burkitt Lymphoma

Burkitt'S Lymphoma	BL
Burkitt Lymphoma, Somatic	Burkitt Lymphoma/Leukaemia
Burkitt'S Tumor	Burkitt'S Tumor Or Lymphoma
Malignant Lymphoma, Burkitt'S Type	Small Non-Cleaved Cell Lymphoma, Burkitt'S Type
Small Non-Cleaved Cell Lymphoma	Burkitt Tumor
Burkitts Lymphoma	Lymphoma, Small Noncleaved-Cell
Burkitt Tumour	Diffuse Small Noncleaved Malignant Burkitt Lymphoma
Malignant Burkitt Lymphoma	“Burkitt-Like” Lymphoma
Undifferentiated Burkitt Lymphoma	Small Noncleaved Cell Burkitt Lymphoma

Li-Fraumeni Syndrome

Sarcoma Family Syndrome Of Li And Fraumeni	Sbla Syndrome
LFS	Li-Fraumeni Familiar Cancer Susceptibility Syndrome
Sarcoma, Breast, Leukaemia And Adrenal Gland Syndrome	Lfs1
Li Fraumeni Syndrome	Sarcoma, Breast, Leukemia, And Adrenal Gland Syndrome
Lfl	Sbla Syndrome Li-Fraumeni-Like Syndrome
Li-Fraumeni Syndrome 1

Familial Retinoblastoma

Hereditary Retinoblastoma

Retinoblastoma

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-148409	MMRi62		99.58%	Unkown
HY-10412	CEP-1347		98.50%	Unkown
HY-123544	RDR03871	MDM2 Inhibitor	/	Unkown
HY-146806	YL93	Inhibitor	/	Unkown
HY-151169	MDM2/4-p53-IN-1	MDM2 Inhibitor	/	Unkown
HY-151170	MDM2/4-p53-IN-2		/	Unkown
HY-151171	MDM2/4-p53-IN-3	Inhibitor	/	Unkown
HY-RS08267	MDM4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	MDM4	MGD	MGI:107934
Canis familiaris	MDM4	VGNC	VGNC:43107
Felis catus	MDM4	VGNC	VGNC:68224
Macaca mulatta	MDM4	VGNC	VGNC:74693
Rattus norvegicus	MDM4	RGD	RGD:1309306
Bos taurus	MDM4	VGNC	VGNC:31337
Others	MDM4	NCBI

Name
Email *

	Sorry, but the email address you supplied was invalid.