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TRAIL/TNFSF10 protein binds to TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, and possibly TNFRSF11B, inducing apoptosis.It can be modulated by decoy receptors TNFRSF10C, TNFRSF10D, and TNFRSF11B, which do not induce apoptosis.TRAIL/TNFSF10 exists as a homotrimer, interacting with its receptor monomers.This complex molecular interaction governs apoptotic signaling pathways.TRAIL/TNFSF10 Protein, Mouse (His) is the recombinant mouse-derived TRAIL/TNFSF10 protein, expressed by E.coli , with N-6*His labeled tag.
The transthyretin/TTR protein is a thyroid hormone binder that may transport thyroxine from the blood to the brain.It exists as a homotetramer forming a dimer of dimers with a ligand-regulated central channel suggested to play a role in thyroxine binding and transport.Transthyretin/TTR Protein, Mouse (HEK293, His) is the recombinant mouse-derived Transthyretin/TTR protein, expressed by HEK293 , with C-10*His labeled tag.
The transferrin R2 protein is a key player in iron-independent cellular uptake of transferrin-bound iron, underscoring its role in delicate iron metabolism. Among other things, it may have crucial effects on liver cell function and red blood cell differentiation. Transferrin R2 Protein, Mouse (HEK293, mFc) is the recombinant mouse-derived Transferrin R2 protein, expressed by HEK293 , with N-mFc labeled tag.
Transferrin is an important iron-binding transport protein that combines two Fe(3+) ions with an anion, usually bicarbonate.Its main function is to transport iron from the site of absorption to the site of storage and utilization.Transferrin Protein, Mouse (HEK293, His) is the recombinant mouse-derived Transferrin protein, expressed by HEK293 , with C-10*His labeled tag.
TRAIL R2/TNFRSF10B protein is the receptor of TNFSF10/TRAIL and activates apoptosis through FADD-mediated recruitment of caspase-8 to form death-inducing signaling complex (DISC).It initiates caspase cascade-mediated apoptosis and promotes NF-kappa-B activation, which is critical for ER stress-induced apoptosis.TRAIL R2/TNFRSF10B Protein, Mouse (HEK293, hFc) is the recombinant mouse-derived TRAIL R2/TNFRSF10B protein, expressed by HEK293 , with C-hFc labeled tag.
TRAIL R2/TNFRSF10B protein is the receptor of TNFSF10/TRAIL and activates apoptosis through FADD-mediated recruitment of caspase-8 to form death-inducing signaling complex (DISC).It initiates caspase cascade-mediated apoptosis and promotes NF-kappa-B activation, which is critical for ER stress-induced apoptosis.TRAIL R2/TNFRSF10B Protein, Mouse (HEK293, His) TRAIL R2/TNFRSF10B Protein, Mouse (HEK293, His) is the recombinant mouse-derived TRAIL R2/TNFRSF10B protein, expressed by HEK293 , with C-His labeled tag.
Transferrin is an important iron-binding transport protein that combines two Fe(3+) ions with an anion, usually bicarbonate.Its main function is to transport iron from the site of absorption to the site of storage and utilization.Transferrin Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived Transferrin protein, expressed by HEK293 , with C-hFc labeled tag.
The transmembrane protease serine 4 (TMPRSS4) protein is a plasma membrane-anchored serine protease that is critical for activating molecular pathways. Its proteolytic activity directly processes pro-uPA/PLAU into its active form. Transmembrane protease serine 4 Protein, Mouse (His-SUMO) is the recombinant mouse-derived Transmembrane protease serine 4 protein, expressed by E. coli , with N-His, N-SUMO labeled tag.
TRAIL R2/TNFRSF10B protein is the receptor of TNFSF10/TRAIL and activates apoptosis through FADD-mediated recruitment of caspase-8 to form death-inducing signaling complex (DISC).It initiates caspase cascade-mediated apoptosis and promotes NF-kappa-B activation, which is critical for ER stress-induced apoptosis.TRAIL R2/TNFRSF10B Protein, Mouse (HEK293, His-Fc) is the recombinant mouse-derived TRAIL R2/TNFRSF10B protein, expressed by HEK293 , with C-hFc, C-His labeled tag.
TRAIL R2/TNFRSF10B protein is the receptor of TNFSF10/TRAIL and activates apoptosis through FADD-mediated recruitment of caspase-8 to form death-inducing signaling complex (DISC).It initiates caspase cascade-mediated apoptosis and promotes NF-kappa-B activation, which is critical for ER stress-induced apoptosis.TRAIL R2/TNFRSF10B Protein, Mouse (HEK293, Avi-His) is the recombinant mouse-derived TRAIL R2/TNFRSF10B protein, expressed by HEK293 , with C-Avi, C-6*His labeled tag.
PLET1 protein orchestrates leading keratinocyte migration and enhances cellular adhesion to matrix proteins, crucial for wound healing. Its role extends to promoting efficient wound repair, emphasizing its significance in tissue regeneration. Additionally, PLET1 may influence trichilemmal differentiation in the hair follicle, indicating a broader impact on skin biology and homeostasis. Placenta-expressed transcript 1 Protein, Mouse (His-SUMO) is the recombinant mouse-derived Placenta-expressed transcript 1 protein, expressed by E. coli , with N-His, N-SUMO labeled tag. The total length of Placenta-expressed transcript 1 Protein, Mouse (His-SUMO) is 191 a.a..
The TGM2/transglutaminase 2 protein is a calcium-dependent acyltransferase involved in bone development, angiogenesis, wound healing, and apoptosis.TGM2 is also involved in neurotransmission-independent actions and serves as a signal transducer in α-1 adrenergic receptor-mediated pathways.TGM2/Transglutaminase 2 Protein, Mouse (His) is the recombinant mouse-derived TGM2/Transglutaminase 2 protein, expressed by E.coli , with N-His labeled tag.
TRAIL/TNFSF10 protein binds to TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, and possibly TNFRSF11B, inducing apoptosis.It can be modulated by decoy receptors TNFRSF10C, TNFRSF10D, and TNFRSF11B, which do not induce apoptosis.TRAIL/TNFSF10 exists as a homotrimer, interacting with its receptor monomers.This complex molecular interaction governs apoptotic signaling pathways.Animal-Free TRAIL/TNFSF10 Protein, Mouse (His) is the recombinant mouse-derived animal-FreeTRAIL/TNFSF10 protein, expressed by E.coli , with C-His labeled tag.
The TCN2/Transcobalamin-2 protein plays a key role as the primary vitamin B12 binding and transporter, ensuring efficient delivery of cobalamin to cells.Its complex interactions involve binding to CD320, specifically to the LDL receptor class A domain.TCN2/Transcobalamin-2 Protein, Mouse (HEK293, C-His) is the recombinant mouse-derived TCN2/Transcobalamin-2 protein, expressed by HEK293 , with C-6*His labeled tag.
The TGM2/transglutaminase 2 protein is a calcium-dependent acyltransferase involved in bone development, angiogenesis, wound healing, and apoptosis.TGM2 is also involved in neurotransmission-independent actions and serves as a signal transducer in α-1 adrenergic receptor-mediated pathways.TGM2/Transglutaminase 2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived TGM2/Transglutaminase 2 protein, expressed by HEK293 , with C-6*His labeled tag.
The TGM2/transglutaminase 2 protein is a calcium-dependent acyltransferase involved in bone development, angiogenesis, wound healing, and apoptosis.TGM2 is also involved in neurotransmission-independent actions and serves as a signal transducer in α-1 adrenergic receptor-mediated pathways.TGM2/Transglutaminase 2 Protein, Mouse (HEK293, C-His) is the recombinant mouse-derived TGM2/Transglutaminase 2 protein, expressed by HEK293 , with C-10*His labeled tag.
The TROP-2 protein functions as a growth factor receptor and has been shown to play a critical role in mediating cellular responses associated with growth regulation. Its involvement indicates that it plays a crucial role in signal transduction during cell growth. TROP-2 Protein, Mouse (HEK293, hFc) is the recombinant mouse-derived TROP-2 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of TROP-2 Protein, Mouse (HEK293, hFc) is 246 a.a., with molecular weight of ~66 kDa.
The TROP-2 protein functions as a growth factor receptor and has been shown to play a critical role in mediating cellular responses associated with growth regulation. Its involvement indicates that it plays a crucial role in signal transduction during cell growth. TROP-2 Protein, Mouse (246a.a, HEK293, His) is the recombinant mouse-derived TROP-2 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of TROP-2 Protein, Mouse (246a.a, HEK293, His) is 246 a.a., with molecular weight of 38-55 kDa.
SLC30A8 Protein, a proton-coupled zinc ion antiporter, crucially regulates insulin secretion. Serving as a mediator, SLC30A8 enables zinc entry into pancreatic beta cell secretory granules, maintaining the required zinc concentration. This process finely tunes insulin release dynamics, emphasizing SLC30A8's pivotal role in physiological insulin secretion control and glucose homeostasis. SLC30A8 Protein, Mouse (Cell-Free, His) is the recombinant mouse-derived SLC30A8 protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of SLC30A8 Protein, Mouse (Cell-Free, His) is 367 a.a., with molecular weight of 43.0&86 kDa.
TREML2 protein acts as a cell surface receptor for SEMA6A and affects key intercellular signaling in cerebellar development. It regulates granule cell migration, coordinates actin cytoskeletal reorganization, and contributes significantly to axonal guidance in the central nervous system. TREML2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived TREML2 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of TREML2 Protein, Mouse (HEK293, His) is 246 a.a., with molecular weight of 58-62 kDa.
Niemann Pick C2/NPC2 Protein, a lysosomal protein, plays a critical role in cholesterol trafficking and lipid metabolism. It facilitates the transport of cholesterol from lysosomes to other cellular compartments. Understanding the functions of NPC2 Protein is vital for studying lipid disorders and developing therapeutic strategies targeting abnormal cholesterol metabolism. Niemann Pick C2/NPC2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Niemann Pick C2/NPC2 protein, expressed by HEK293 , with C-His labeled tag. The total length of Niemann Pick C2/NPC2 Protein, Mouse (HEK293, His) is 130 a.a., with molecular weight of ~15.9-19 kDa.
TREML1 is a trigger receptor 1 expressed on myeloid cells that activates myeloid cells via the adaptor protein DAP12. TREML1 promotes microglial phagocytosis of Aβ and is associated with the immune response to AD. TREML1 Protein, Mouse (HEK293, hFc) is the recombinant mouse-derived TREML1 protein, expressed by HEK293 , with C-hFc labeled tag.
The ACP5 protein may have a crucial role in bone resorption, particularly in the enzymatic activities involved in breaking down bone tissue. ACP5 is linked to the osteoclastic trap, which has higher affinity for nucleotide tri- and diphosphates. Understanding ACP5's mechanisms in bone resorption and its interactions with nucleotide substrates could offer insights into its role in maintaining bone health. ACP5 Protein, Mouse (HEK293, His) is the recombinant mouse-derived ACP5 protein, expressed by HEK293 , with C-His labeled tag. The total length of ACP5 Protein, Mouse (HEK293, His) is 305 a.a., with molecular weight of ~35.8-38 kDa.
CD40L (CD154; TRAP) is a ligand to CD40/TNFRSF5, acts function by generating a costimulatory signal that up-regulates IL-4 synthesis. CD40L is specifically expressed on activated CD4+ T-lymphocytes and involves in activation of NF-κB/MAPK pathway. CD40L also involves in B cell differentiation, maturation, and apoptosis. CD40L in mouse, cleaved into 2 chains of membrane form (1-260 a.a.) and soluble form (112-260 a.a.) which serves as a ligand for integrins (ITGA5:ITGB1 and ITGAV:ITGB3). CD40L/CD154/TRAP Protein, Mouse (HEK293, Fc) is expressed in HEK392 cells with N-terminal hFc-tag.
OX40 (TNFRSF4), is a receptor for OX40 Ligand. OX40 is preferentially expressed by T cells. OX40 can be activated by OX40 Ligand, thereby functioning as a T cell co-stimulatory molecule. The OX40-OX40 Ligand interaction promotes effector T-cell survival and effectively induces memory T-cell generation, as well as enhances the helper function of Tfh for B cells, and also promotes the differentiation and maturation of DCs. OX40/TNFRSF4 Protein, Mouse (Biotinylated, HEK293, His-Avi) is a recombinant biotinylated mouse OX40 (V20-P211) with C-terminal Avi and His tag, which is produced in HEK293.
CD40L (CD154; TRAP) is a ligand to CD40/TNFRSF5, acts function by generating a costimulatory signal that up-regulates IL-4 synthesis. CD40L is specifically expressed on activated CD4+ T-lymphocytes and involves in activation of NF-κB/MAPK pathway. CD40L also involves in B cell differentiation, maturation, and apoptosis. CD40L in mouse, cleaved into 2 chains of membrane form (1-260 a.a.) and soluble form (112-260 a.a.) which serves as a ligand for integrins (ITGA5:ITGB1 and ITGAV:ITGB3). CD40L/CD154/TRAP Trimer Protein, Mouse (HEK293, Fc) has a total length of 149 amino acids (M112-L260), is expressed in HEK392 cells with N-terminal hFc-tag.
Cyclophilin A protein catalyzes the isomerization of proline imide peptide bonds in oligopeptides. Cyclophilin A Protein, Mouse is the recombinant mouse-derived Cyclophilin A protein, expressed by E. coli , with tag free.
Cyclophilin A protein catalyzes the isomerization of proline imide peptide bonds in oligopeptides. Cyclophilin A Protein, Mouse (solution) is the recombinant mouse-derived Cyclophilin A protein, expressed by E. coli , with tag free. The total length of Cyclophilin A Protein, Mouse is 164 a.a., with molecular weight of ~17.0 kDa.
ART4/CD297 Protein , a protein that contains a mono-ADP-ribosylation (ART) motif, is involved in peptidyl-arginine ADP-ribosylation. It is a member of the ADP-ribosyltransferase gene family. ART4 is expressed in several structures, including cardiovascular system, genitourinary system, integumental system, liver; and sensory organ. In addition, ART4 plays an important role in erythrocyte invasion by P. falciparum. ART4/CD297 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived ART4/CD297 protein, expressed by HEK293 , with C-hFc labeled tag.
ART4/CD297 Protein , a protein that contains a mono-ADP-ribosylation (ART) motif, is involved in peptidyl-arginine ADP-ribosylation. It is a member of the ADP-ribosyltransferase gene family. ART4 is expressed in several structures, including cardiovascular system, genitourinary system, integumental system, liver; and sensory organ. In addition, ART4 plays an important role in erythrocyte invasion by P. falciparum. ART4/CD297 Protein, Mouse (HEK293, His) is the recombinant mouse-derived ART4/CD297 protein, expressed by HEK293 , with C-His labeled tag.
CD40L (CD154; TRAP) is a ligand to CD40/TNFRSF5, acts function by generating a costimulatory signal that up-regulates IL-4 synthesis. CD40L is specifically expressed on activated CD4+ T-lymphocytes and involves in activation of NF-κB/MAPK pathway. CD40L also involves in B cell differentiation, maturation, and apoptosis. CD40L in mouse, cleaved into 2 chains of membrane form (1-260 a.a.) and soluble form (112-260 a.a.) which serves as a ligand for integrins (ITGA5:ITGB1 and ITGAV:ITGB3). CD40L/CD154/TRAP Protein, Mouse (HEK293, His) has a total length of 149 amino acids (M112-L260), is expressed in HEK392 cells with N-terminal 6*His-tag.
RANKL (TNFSF11), a type II transmembrane protein, is a receptor activator of NF-κB (RANK) ligand. RANKL is an activator of RANK. When binding to RANK, it induces the differentiation of monocyte/macrophage-lineage cells into osteoclasts and leads to osteoclast precursor maturation. RANKL is critical for osteoclasts maturation, bone modeling, and bone remodeling, as well as the development of lymph nodes (LNs). RANKL/TNFSF11 Protein, Mouse is a recombinant mouse RANKL (Q137-D316) without tag, which is produced in E.coli.
Cyclophilin A (PPIA) protein, with integrin binding and peptidyl-prolyl cis-trans isomerase activity, influences platelet aggregation and neuron differentiation. It is found in the extracellular space and myelin sheath, showing ubiquitous expression in various tissues, including the liver and central nervous system. PPIA is associated with cholangiocarcinoma and HIV disease, suggesting its role in fundamental cellular processes. Cyclophilin A Protein, Mouse (His) is the recombinant mouse-derived Cyclophilin A protein, expressed by E. coli , with C-His labeled tag.
Serpin A6 Protein serves as the primary transport protein for glucocorticoids and progestins in the blood of nearly all vertebrate species. Serpin A6 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Serpin A6 protein, expressed by HEK293 , with C-His labeled tag. The total length of Serpin A6 Protein, Mouse (HEK293, His) is 375 a.a., with molecular weight of 50-60 kDa.
CHODL proteins contribute significantly to nervous system development, particularly in neurite growth and elongation. There is evidence that it is involved in guiding motor axon growth and shaping the structural framework of the nervous system. CHODL Protein, Mouse (HEK293, His) is the recombinant mouse-derived CHODL protein, expressed by HEK293 , with C-His labeled tag.
The FKBP12 protein is multifunctional and critical in TGF-β signaling by maintaining TGFBR1 in an inactive conformation, thereby preventing receptor activation in the absence of ligand. It recruits SMAD7 to ACVR1B, blocks the binding of SMAD2 and SMAD3 to the activin receptor complex, and thereby inhibits activin signaling. FKBP12 Protein, Mouse (His) is the recombinant mouse-derived FKBP12 protein, expressed by E. coli , with N-His labeled tag. The total length of FKBP12 Protein, Mouse (His) is 107 a.a., with molecular weight of ~13 KDa.
The LRRTM3 protein may contribute to the development and maintenance of the vertebrate nervous system, and in vitro studies highlight its synaptic activity. LRRTM3 specifically affects the differentiation of excitatory presynaptic elements, emphasizing its role in shaping synaptic connections associated with excitatory neurotransmission. LRRTM3 Protein, Mouse (CHO, His) is the recombinant mouse-derived LRRTM3 protein, expressed by CHO , with C-His labeled tag.
RANKL/TNFSF11 Protein, Mouse (CHO) is a TNF-related activation-induced cytokine produced in CHO. Mouse and human RANK Ligand share 85% amino acid identity. RANK L/TNFSF11 Protein, Mouse (CHO, His) induces the activation of the c-jun N terminal kinase, enhances T cell growth and dendritic cell function, induces osteoclastogenesis, and lymph node organogenesis.
LRRTM4 protein is crucial for vertebrate nervous system development and maintenance. It exhibits synaptogenic activity, limited to excitatory presynaptic differentiation. LRRTM4 is associated with the AMPAR complex, regulating AMPAR complex function and synaptic processes. Understanding LRRTM4's interactions within the complex could offer insights into its role in synaptic regulation and neural connectivity. LRRTM4 Protein, Mouse (HEK293, His) is the recombinant mouse-derived LRRTM4 protein, expressed by HEK293 , with C-His labeled tag.
The TMEM106B protein is a key player in neurons involved in trafficking to late endosomes/lysosomes and potentially affects dendritic morphogenesis and maintenance by regulating lysosomal trafficking. It may act as a molecular brake on retrograde transport by interacting with MAP6. TMEM106B Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived TMEM106B protein, expressed by HEK293 , with C-hFc labeled tag. The total length of TMEM106B Protein, Mouse (HEK293, Fc) is 157 a.a., with molecular weight of 65-68 kDa.
GPNMB/bone active protein shows promise as a melanogenic enzyme, possibly involved in melanin synthesis. Its regulatory influence on melanin production highlights its critical role in pigment formation. GPNMB/Osteoactivin Protein, Mouse (HEK293, His) is the recombinant mouse-derived GPNMB/Osteoactivin protein, expressed by HEK293 , with C-His labeled tag. The total length of GPNMB/Osteoactivin Protein, Mouse (HEK293, His) is 480 a.a., with molecular weight of ~96 kDa.
The Collectrin protein plays a crucial role in amino acid transport by binding to SLC6A18 and SLC6A19 and regulating their surface transport and activity. Furthermore, it may affect the trafficking of SLC3A1 and SLC7A9 to the renal cortical cell membrane. Collectrin/TMEM27 Protein, Mouse (Myc, His-SUMO) is the recombinant mouse-derived Collectrin protein, expressed by E. coli , with N-His, C-Myc, N-SUMO labeled tag.
The CD24 protein may coordinate cellular differentiation of various cell types, particularly in early thymocyte development. Activation of its signaling involves binding of a lectin-like ligand to the CD24 carbohydrate, triggering the release of second messengers from GPI anchors. CD24 Protein, Mouse (HEK293, hFc) is the recombinant mouse-derived CD24 protein, expressed by HEK293 , with C-hFc labeled tag.
TFRC is a key protein in cellular iron uptake, coordinating receptor-mediated endocytosis of the ligand transferrin into specialized endosomes, where endosomal acidification triggers iron release.TFRC actively regulates T and B cell proliferation through iron uptake.TFRC Protein, Mouse (HEK293, His) is the recombinant mouse-derived TFRC protein, expressed by HEK293 , with N-8*His labeled tag.
The FLRT2 protein plays a key role in cell-cell adhesion, migration, and axonal guidance. Its interaction with ADGRL3 promotes cell-cell adhesion and promotes cortical neuronal migration through interaction with UNC5D. FLRT2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived FLRT2 protein, expressed by HEK293 , with C-His labeled tag. The total length of FLRT2 Protein, Mouse (HEK293, His) is 504 a.a., with molecular weight of 60-80 kDa.
The CDCP1 protein has been implicated in cell adhesion and matrix association, suggesting a role in important cellular interactions. Its phosphorylation suggests a dynamic function in regulating anchorage, migration, proliferation, or differentiation. CDCP1 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived CDCP1 protein, expressed by HEK293 , with C-hFc labeled tag.
OSTM1 Protein is crucial for osteoclast and melanocyte maturation and function, forming heteromers with alpha subunits (CLCN7) to create chloride channel 7. OSTM1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived OSTM1 protein, expressed by HEK293 , with C-His labeled tag. The total length of OSTM1 Protein, Mouse (HEK293, His) is 254 a.a., with molecular weight of ~29.7 KDa.
The CDCP1 protein has been implicated in cell adhesion and matrix association, suggesting a role in important cellular interactions. Its phosphorylation suggests a dynamic function in regulating anchorage, migration, proliferation, or differentiation. CDCP1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived CDCP1 protein, expressed by HEK293 , with C-His labeled tag.
TFAM proteins are critical in the regulation of mitochondrial transcription, bind to light chain promoters and are essential for basal mitochondrial DNA transcription.In the initiation complex of TFB2M and POLRMT, TFAM recruits POLRMT, and TFB2M induces structural changes in POLRMT, promoting promoter opening.TFAM Protein, Mouse (His, Myc) is the recombinant mouse-derived TFAM protein, expressed by E.coli , with N-10*His, C-Myc labeled tag.
The TSPO protein was originally thought to be a peripheral benzodiazepine receptor that binds protoporphyrin IX and isoquinoline carboxamide. TSPO Protein, Mouse (Cell-Free, His) is the recombinant mouse-derived TSPO protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of TSPO Protein, Mouse (Cell-Free, His) is 169 a.a., with molecular weight of 21.7 kDa.
TROY Protein also known as TAJ, TNFRSF19, a type I transmembrane receptor, is a member of the TNF receptor superfamily. TROY Protein is involved in embryonic development and the development of skin and hair follicles. TROY Protein inhibits cell proliferation in vitro and shows antitumor activity in xenografted models. TROY/TNFRSF19 Protein, Mouse (HEK293, His) is a recombinant protein with a C-Terminal His label, It consists of 170 amino acids (M1-L170) and is produced in HEK293 cells.
TROY Protein also known as TAJ, TNFRSF19, a type I transmembrane receptor, is a member of the TNF receptor superfamily. TROY Protein is involved in embryonic development and the development of skin and hair follicles. TROY Protein inhibits cell proliferation in vitro and shows antitumor activity in xenografted models. TROY/TNFRSF19 Protein, Mouse (HEK293, Fc) is a recombinant protein with a C-Terminal Fc label, It consists of 141 amino acids (E30-L170) and is produced in HEK293 cells.
The ATP1B1 protein is a noncatalytic component that forms a heterodimer with the α subunit and catalyzes ATP hydrolysis and Na(+) and K(+) ion exchange across the plasma membrane. These heterodimers critically regulate sodium pumping at the plasma membrane, affecting ion balance. ATP1B1 Protein, Mouse (Cell-Free, His) is the recombinant mouse-derived ATP1B1 protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of ATP1B1 Protein, Mouse (Cell-Free, His) is 304 a.a., with predicted molecular weight of 36.7 kDa.
RANKL (TNFSF11), a type II transmembrane protein, is a receptor activator of NF-κB (RANK) ligand. RANKL is an activator of RANK. When binding to RANK, it induces the differentiation of monocyte/macrophage-lineage cells into osteoclasts and leads to osteoclast precursor maturation. RANKL is critical for osteoclasts maturation, bone modeling, and bone remodeling, as well as the development of lymph nodes (LNs). RANK L/TNFSF11 Protein, Mouse (HEK293, C-His) is a recombinant mouse RANKL (R72-D316) with N-terminal 6*His tag, which is produced in HEK293.
The DR3/TNFRSF25 protein displays defects in conserved residues critical for propagation feature annotation. This defect in DR3/TNFRSF25 prevents the propagation of specific functional features associated with this protein. DR3/TNFRSF25 Protein, Mouse (HEK293, His) is the recombinant mouse-derived DR3/TNFRSF25 protein, expressed by HEK293 , with C-His labeled tag. The total length of DR3/TNFRSF25 Protein, Mouse (HEK293, His) is 166 a.a., with molecular weight of 35-48 kDa.
The dermapontin (DPT) protein mediates adhesion by binding to integrins on the cell surface and serves as a communication link between dermal fibroblasts and the extracellular matrix. It enhances TGFB1 activity, inhibits cell proliferation, accelerates collagen fiber formation, and stabilizes its resistance to low-temperature dissociation. Dermatopontin/DPT Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived Dermatopontin/DPT protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Dermatopontin/DPT Protein, Mouse (HEK293, Fc) is 183 a.a., with molecular weight of ~55 kDa.
RNF43 Protein, a receptor tyrosine kinase, regulates the Wnt signaling pathway by promoting the degradation of Frizzled receptors. It plays a crucial role in embryonic development and tissue homeostasis. Dysregulation of RNF43 Protein is associated with various cancers, making it a potential therapeutic target in cancer treatment. RNF43 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived RNF43 protein, expressed by HEK293 , with C-hFc labeled tag.
The CDCP1 protein has been implicated in cell adhesion and matrix association, suggesting a role in important cellular interactions. Its phosphorylation suggests a dynamic function in regulating anchorage, migration, proliferation, or differentiation. CDCP1 Protein, Mouse (Biotinylated, HEK293, His-Avi) is the recombinant mouse-derived CDCP1 protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of CDCP1 Protein, Mouse (Biotinylated, HEK293, His-Avi) is 643 a.a., with molecular weight of 80-110 kDa.
Contactin-2/CNTN2 Protein collaborates with transmembrane protein CNTNAP2, crucially organizing axonal domains at nodes of Ranvier.This partnership maintains voltage-gated potassium channels at the juxtaparanodal region, emphasizing Contactin-2's pivotal role in the intricate molecular architecture essential for efficient nerve impulse propagation along myelinated axons.Contactin-2/CNTN2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Contactin-2/CNTN2 protein, expressed by HEK293 , with C-His labeled tag.
TMED1, or Transmembrane p24 trafficking protein 1, is a member of the EMP24/GP25L family. TMED1 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived TMED1 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of TMED1 Protein, Mouse (HEK293, Fc) is 170 a.a., with molecular weight of ~56-60 KDa.
TGF beta 1/TGFB1 Protein is initially identified as a growth factor that induces the growth of rodent fibroblasts. TGF beta 1/TGFB1 Protein inhibits the cell cycle in the G1 phase. TGF beta 1/TGFB1 is an endogenous factor controlling apoptosis in normal and pathological tissues. TGF beta 1/TGFB1 Protein, Mouse (HEK293) is a recombinant protein (A279-S390) produced by HEK293 cells.
RANKL (TNFSF11), a type II transmembrane protein, is a receptor activator of NF-κB (RANK) ligand. RANKL is an activator of RANK. When binding to RANK, it induces the differentiation of monocyte/macrophage-lineage cells into osteoclasts and leads to osteoclast precursor maturation. RANKL is critical for osteoclasts maturation, bone modeling, and bone remodeling, as well as the development of lymph nodes (LNs). RANKL/TNFSF11 Protein, Mouse (HEK293, Fc) is a recombinant mouse RANKL (R72-D316) with N-terminal hFc tag, which is produced in HEK293.
In its proprotein form, the TGF beta-1/TGFB1 protein serves as a precursor to latency-associated peptide (LAP) and active transforming growth factor beta-1 (TGF-beta-1) chains.Critical to maintaining the latent state of TGF-β-1 within the extracellular matrix, preprotein interacts with “environmental molecules” such as LTBP1, LRRC32/GARP, and LRRC33/NRROS to regulate TGF-β-1 activation.Animal-Free TGF beta 1/TGFB1 Protein, Mouse (His) is the recombinant mouse-derived animal-FreeTGF beta 1/TGFB1 protein, expressed by E.coli , with C-His labeled tag.
TCblR/CD320 Protein, the receptor for cobalamin-saturated transcobalamin (TCbl), plays a pivotal role in cobalamin uptake, expressed on the plasma membrane and notably on follicular dendritic cells (FDC). As a costimulator, TCblR promotes B cell responses, fostering differentiation and proliferation. It's particularly influential in differentiating germinal center-B cells, engaging in collaborative interactions with T-cells and FDC. CD320 enhances IL-10-induced precursor proliferation, underscoring its significance in cobalamin homeostasis and cellular processes through interactions with TCN2. TCblR/CD320 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived TCblR/CD320 protein, expressed by HEK293, with C-hFc labeled tag. The total length of TCblR/CD320 Protein, Mouse (HEK293, Fc) is 208 a.a., with molecular weight of ~72.5 kDa.
TCblR/CD320 Protein, the receptor for cobalamin-saturated transcobalamin (TCbl), plays a pivotal role in cobalamin uptake, expressed on the plasma membrane and notably on follicular dendritic cells (FDC). As a costimulator, TCblR promotes B cell responses, fostering differentiation and proliferation. It's particularly influential in differentiating germinal center-B cells, engaging in collaborative interactions with T-cells and FDC. CD320 enhances IL-10-induced precursor proliferation, underscoring its significance in cobalamin homeostasis and cellular processes through interactions with TCN2. TCblR/CD320 Protein, Mouse (HEK293, His) is the recombinant mouse-derived TCblR/CD320 protein, expressed by HEK293, with C-His labeled tag. The total length of TCblR/CD320 Protein, Mouse (HEK293, His) is 208 a.a., with molecular weight of ~47.7 kDa.
TMEFF1/Tomoregulin-1 Protein is a transmembrane protein involved in the physiological functions of the central nervous system, embryonic development, and other biological processes. TMEFF1 may inhibit NODAL and BMP signaling during neural patterning. And it may be a tumor suppressor in brain cancers. Additionally, the protein may interact with ST14, implying a molecular association that may contribute to its regulatory and signaling functions. TMEFF1/Tomoregulin-1 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived TMEFF1/Tomoregulin-1 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of TMEFF1/Tomoregulin-1 Protein, Mouse (HEK293, Fc) is 298 a.a., with molecular weight of ~69 kDa.
PVRIG Protein, a member of the nectin and nectin-like family, is an immune checkpoint molecule with potential for development. PVRIG binds with high affinity to PVRL2 are inhibitory receptors on effector T cells, suppressing cytokine production and cytotoxic activity. PVRIG blocking antibodies significantly increased NK-cell cytotoxicity. PVRIG Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived PVRIG protein, expressed by HEK293 , with C-hFc labeled tag. The total length of PVRIG Protein, Mouse (HEK293, Fc) is 131 a.a., with molecular weight of 48-55 kDa.
TGFBR3/TGF-beta RIII Protein is pivotal, binding to TGF-beta, indicating a potential role in capturing and presenting TGF-beta to signaling receptors.In gonadotrope cells, it acts as an inhibin A coreceptor, regulating FSH levels and impacting female fertility.Its interaction with DYNLT4 emphasizes diverse functional associations in cellular processes, suggesting a multifaceted role for TGFBR3 in cellular regulation and fertility control.TGFBR3/TGF-beta RIII Protein, Mouse (HEK293, His) is the recombinant mouse-derived TGFBR3/TGF-beta RIII protein, expressed by HEK293 , with C-6*His labeled tag.
TIGIT protein, with signaling receptor binding activity, functions upstream of T cell activation suppression. Active on the cell surface, it shares orthology with human TIGIT. Associated with modulating T cell responses, TIGIT exhibits biased expression, notably in the large intestine, small intestine, and other tissues. This highlights its potential in immune regulation within these contexts. TIGIT Protein, Mouse (110a.a, HEK293, His) is the recombinant mouse-derived TIGIT protein, expressed by HEK293 , with C-6*His labeled tag. The total length of TIGIT Protein, Mouse (110a.a, HEK293, His) is 110 a.a., with molecular weight of 15-22 kDa.
The cathepsin C/DPPI protein is a thiol protease that acts as a dipeptidyl peptidase with multiple substrate specificities, excluding proline at the P1 position and arginine at the P2 position. It has both exopeptidase and endopeptidase functions and can activate serine proteases such as elastase, cathepsin G, and granzymes A and B. Cathepsin C/DPPI Protein, Mouse (His-Myc) is the recombinant mouse-derived Cathepsin C/DPPI protein, expressed by E. coli , with N-10*His, C-Myc labeled tag. The total length of Cathepsin C/DPPI Protein, Mouse (His-Myc) is 110 a.a., with molecular weight of 20.1 kDa.
RANKL (TNFSF11), a type II transmembrane protein, is a receptor activator of NF-κB (RANK) ligand. RANKL is an activator of RANK. When binding to RANK, it induces the differentiation of monocyte/macrophage-lineage cells into osteoclasts and leads to osteoclast precursor maturation. RANKL is critical for osteoclasts maturation, bone modeling, and bone remodeling, as well as the development of lymph nodes (LNs). Animal-Free RANK L/TNFSF11 Protein, Mouse (His) is a recombinant mouse RANKL (P143-D316) with C-terminal His tag, which is produced in E.coli.
RET protein is an important receptor tyrosine protein kinase that drives a variety of cellular processes such as proliferation, migration, and differentiation when bound to GDNF ligand. It coordinates organogenesis, shapes the enteric nervous system and promotes kidney development. RET Protein, Mouse (HEK293, His) is the recombinant mouse-derived RET protein, expressed by HEK293 , with C-6*His labeled tag and F174S mutation. The total length of RET Protein, Mouse (HEK293, His) is 609 a.a.
Transforming growth factor-beta 2 (TGF-β2), an extracellular glycosylated protein, is a member of the TGF-β superfamily. TGFβ2 controls key physiological processes including cell migration, proliferation and differentiation via signalling through type I and type II receptors (TGFβR1 and TGFβR2). TGF-β2 is an immune suppressor involved in the development of immune tolerance, and also regulates embryonic development. TGF beta 2/TGFB2 Protein, Mouse/Rat (HEK293) is produced in HEK293 cells.
TRIM21 is an E3 ubiquitin protein ligase that forms complexes with E2 enzymes including UBE2D1 and UBE2E2.It cooperates with UBE2D2 to ubiquitinate USP4, IKBKB and itself, and binds to SCF E3 ligase to mediate ubiquitination of CDKN1B.TRIM21 Protein, Mouse (His-SUMO) is the recombinant mouse-derived TRIM21 protein, expressed by E.coli , with N-His, N-SUMO labeled tag.
TGF beta 1/TGFB1 Protein, Mouse/Rat (HEK293), is a recombinant cytokine produced in HEK293 cells, is implicated as a key regulator of the development and cyclic remodelling characteristic of reproductive tissues.
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