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D1-receptors

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (12) Adenylate Cyclase (1) Adrenergic Receptor (13) Apoptosis (3) Arrestin (2) Dopamine Receptor (73) Drug Metabolite (1) Histone Demethylase (1) Isotope-Labeled Compounds (5) mGluR (2) Parasite (3) STAT (5) YAP (1)
By Research Areas:	Cancer (12) Cardiovascular Disease (4) Endocrinology (11) Inflammation/Immunology (1) Metabolic Disease (1) Neurological Disease (64)

Inhibitors & Agonists

Peptides

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Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-13720A

Pergolide mesylate 1 Publications Verification Pergolide methanesulfonate; LY127809	Dopamine Receptor	Neurological Disease
Pergolide mesylate (Pergolide methanesulfonate), an Ergoline derivative, is a potent and orally active dopamine D₁ and D₂ receptors agonist. Pergolide mesylate can be used for Parkinson's disease and hyperprolactinaemia research ^[1] .

HY-12236A

SKF 81297	Dopamine Receptor	Neurological Disease
SKF 81297 is a potent and selective dopamine D1 receptor agonist ^[1].

HY-12236

SKF 81297 hydrobromide	Dopamine Receptor	Neurological Disease
SKF 81297 hydrobromide is a potent and selective dopamine D1 receptor agonist ^[1].

HY-103431

A68930 hydrochloride	Dopamine Receptor	Others
A68930 hydrochloride, as a dopamine D1 receptor agonist, can be used for the research of bronchiectasis ^[1].

HY-13720AR

Pergolide (mesylate) (Standard)	Dopamine Receptor	Neurological Disease
Pergolide (mesylate) (Standard) is the analytical standard of Pergolide (mesylate). This product is intended for research and analytical applications. Pergolide mesylate (Pergolide methanesulfonate), an Ergoline derivative, is a potent and orally active dopamine D1 and D2 receptors agonist. Pergolide mesylate can be used for Parkinson's disease and hyperprolactinaemia research ^[1] .

HY-116773

A-69024	Dopamine Receptor	Neurological Disease
A-69024 is a selectivity dopamine D-1 receptor antagonist with the K_i values of 12.6 nM and 1290 nM for dopamine D-1 receptor and dopamine D-2 receptor, respectively ^[1].

HY-115553

DETQ	Dopamine Receptor	Neurological Disease
DETQ is a selective, allosteric and orally active dopamine D1 receptor (Dopamine Receptor) potentiator. In HEK293 cells expressing the human D1 receptor, DETQ increases cAMP with an EC₅₀ of 5.8 nM and a K_b of 26 nM. DETQ shows ~30-fold less potent at rat and mouse D1 receptors and is inactive at the human D5 receptor ^[1].

HY-103411

SKF83822 hydrobromide	Dopamine Receptor	Neurological Disease
SKF83822 hydrobromide is a potent dopamine D1 receptor agonist. SKF83822 hydrobromide activates G_s/_olf/adenylyl cyclase (AC)-coupled D1 receptors, but not phospholipase C (PLC)-coupled D1-like receptors ^[1].

HY-159527

Glovadalenum Glovadalen	Dopamine Receptor	Neurological Disease
Glovadalenum (Glovadalen) is a dopamine D1 receptor positive allosteric modulator ^[1].

HY-120687

A68930	Dopamine Receptor	Cancer
A68930, as a dopamine D1 receptor agonist, can be used for the research of bronchiectasis ^[1].

HY-101299

(+)-Dihydrexidine hydrochloride (+)-DAR-0100 hydrochloride	Dopamine Receptor	Neurological Disease
(+)-Dihydrexidine hydrochloride ((+)-DAR-0100 hydrochloride) is a dopamine D1 receptor agonist with an EC₅₀ of 72± 21 nM.

HY-N5140

Bacopaside X Bacopaside VII	Dopamine Receptor	Others
Bacopaside X is found in Bacopa monnieri, and shows a binding affinity toward the D1 receptor ^[1].

HY-106094

CY 208-243 2 Publications Verification	Dopamine Receptor	Neurological Disease
CY 208-243 is a selective dopamine D1 receptor agonist which exhibits antiparkinsonian activity ^[1].

HY-12520A

SKF 38393 hydrochloride Maximum Cited Publications 15 Publications Verification (±)-SKF-38393 hydrochloride; SKF-38393A	Dopamine Receptor	Neurological Disease
SKF 38393 hydrochloride is a selective agonist of the dopamine D1 receptor (D1DR) with an IC₅₀ of 110 nM ^[1].

HY-137254

SKF-80723	Dopamine Receptor	Neurological Disease
SKF-80723 is a D1 receptor agonist and can be used for study of Parkinson's disease ^[1] .

HY-B0735

Fenoldopam SKF 82526	Dopamine Receptor	Cardiovascular Disease
Fenoldopam(SKF 82526) is a drug and synthetic benzazepine derivative which acts as a selective D1 receptor partial agonist.

HY-141496

A-77636	Dopamine Receptor	Neurological Disease
A-77636 is an orally active, potent, selective and long-acting dopamine D1 receptor agonist (pEC50 = 8.13; EC50 = 1.1 nM). A-77636 shows the highest affinity (pKi = 7.40 ± 0.09; Ki = 39.8 nM) for the dopamine D1 receptor. A-77636 shows antiparkinsonian activity ^[1].

HY-14690B

rel-Ecopipam hydrobromide rel-SCH 39166 hydrobromide	Dopamine Receptor	Neurological Disease
rel-Ecopipam (rel-SCH 39166) (Compound 6b) hydrobromide is a D1 receptor antagonist (K_i: 1.30 nM) ^[1].

HY-U00077

Org-10490	Dopamine Receptor	Neurological Disease
Org-10490 is an antagonist of dopamine D1 receptor and dopamine D2 receptor, used for the treatment for psychiatric disease.

HY-10435

SKF-82958 (±)-SKF-82958; Chloro-APB	Dopamine Receptor	Neurological Disease
SKF-82958 ((±)-SKF 82958) is a dopamine D1 receptor full agonist (K_0.5=4 nM), displays selective for D1 over D2 receptors (K_0.5=73 nM). SKF-82958 induces dopamine D1 receptor-dependent adenylate cyclase activity in rat striatal membranes (EC₅₀=491 nM) ^[1].

HY-12237

SKF 38393 hydrobromide (±)-SKF-38393 hydrobromide	Dopamine Receptor	Neurological Disease
SKF 38393 ((±)-SKF-38393) hydrobromide is a selective agonist of the dopamine D1 receptor (D1DR) with an IC₅₀ of 110 nM ^[1].

HY-125043

SKF-75670 hydrobromide	Dopamine Receptor	Neurological Disease
SKF-75670 hydrochloride is a Dopamine D1 receptor partial agonist. SKF-75670 hydrochloride is also a Cocaine antagonist ^[1] .

HY-148867

UCM-1306 2-(Fluoromethoxy)-4'-(S-methylsulfonimidoyl)-1,1'-biphenyl	Dopamine Receptor	Neurological Disease
UCM-1306 is a potent and orally active human dopamine D1 receptor allosteric modulator (PAM). UCM-1306 increases the endogenous dopamine (DA) maximal effect both in human and mouse D1 receptors. UCM-1306 is not only for improving motor symptoms but also for addressing the key comorbid cognitive impairment associated with long-term Parkinson’s disease (PD) ^[1].

HY-10435A

SKF-82958 hydrobromide 3 Publications Verification (±)-SKF-82958 hydrobromide; Chloro-APB hydrobromide	Dopamine Receptor	Neurological Disease
SKF-82958 ((±)-SKF 82958) hydrobromide is a dopamine D1 receptor full agonist (K_0.5=4 nM), displays selective for D1 over D2 receptors (K_0.5=73 nM). SKF-82958 hydrobromide induces dopamine D1 receptor-dependent adenylate cyclase activity in rat striatal membranes (EC₅₀=491 nM) ^[1].

HY-103417

SKF 77434 hydrobromide	Dopamine Receptor	Neurological Disease
SKF 77434 hydrobromide is a selective dopamine D1 receptor partial agonist. SKF 77434 hydrobromide has the potential to study cocaine addiction ^[1].

HY-12236B

(R)-SKF-81297 hydrobromide	Dopamine Receptor	Neurological Disease
(R)-SKF-81297 hydrobromide is the R-enantiomer of SKF-81297 (HY-12236A). SKF-81297 is a selective agonist for dopamine D1 receptor ^[1].

HY-125020

NCGC00135472	Arrestin	Inflammation/Immunology
NCGC00135472 is a potent agonist of resolvin D1 receptor (DRV1), with the EC₅₀ of 0.37 nM and 0.05 μM for β-arrestin and cAMP activities, respectively ^[1].

HY-144291

LY3154885	Dopamine Receptor	Neurological Disease
LY3154885 is an orally active dopamine D1 receptor positive allosteric modulator (PAM). LY3154885 has an improved agent-agent interactions (DDI) risk profile ^[1].

HY-129059

Odapipam 1 Publications Verification NNC 756	Dopamine Receptor	Neurological Disease
Odapipam (NNC 756) is a selective, high affinity and benzazepine dopamine D₁ receptor antagonist with a K_d of 0.18 nM. Odapipam is also a superior positron emission tomography (PET) radiotracer ^[1] .

HY-128770

LY3154207 1 Publications Verification	Dopamine Receptor	Neurological Disease
LY3154207 is a potent, subtype selective, and orally available human dopamine D1 receptor positive allosteric modulator (PAM) with minimal allosteric agonist activity (EC₅₀=3 nM) ^[1].

HY-103427

NPEC-caged-dopamine	Dopamine Receptor	Neurological Disease
NPEC-caged-dopamine is a caged version of dopamine. NPEC-caged-Dopamine was used by applying focal photolysis with UV light (360 nm) to releases dopamine, which leads to D1 receptor activation ^[1].

HY-N5140R

Bacopaside X (Standard)	Dopamine Receptor	Others
Bacopaside X (Standard) is the analytical standard of Bacopaside X. This product is intended for research and analytical applications. Bacopaside X is found in Bacopa monnieri, and shows a binding affinity toward the D1 receptor ^[1].

HY-119943

PF-06256142 1 Publications Verification	Dopamine Receptor	Neurological Disease
PF-06256142 is a potent, selective, CNS-penetrant and orally active agonist of the D1 receptor, with an EC₅₀ and K_i of 33 nM and 12 nM, respectively. PF-06256142 has the potential for the research of schizophrenia and Parkinson's disease ^[1].

HY-119943B

(R)-PF-06256142	Dopamine Receptor	Neurological Disease
(R)-PF-06256142 is the R enantiomer of PF-06256142 with low active. PF-06256142 is a potent and selective orthosteric D1 receptor agonist that can reduce receptor desensitization relative to dopamine and other catechol-containing agonists ^[1].

HY-N2003

D-Tetrahydropalmatine	Dopamine Receptor	Metabolic Disease
D-Tetrahydropalmatine is an isoquinoline alkaloid, mainly in the genus Corydalis ^[1]. D-Tetrahydropalmatine is a dopamine (DA) receptor antagonist with preferential affinity toward the D1 receptors . D-Tetrahydropalmatine is a potent organic cation transporter 1 (OCT1) inhibitor .

HY-N6960

L-Stepholidine Stepholidine; (-)-Stepholidine; L-SPD	Dopamine Receptor	Neurological Disease
L-Stepholidine (Stepholidine) exhibits mixed dopamine D1 receptor agonist and D2 antagonist properties. L-Stepholidine has neuroprotective effect and inhibits Heroin-induced reinstatement. L-Stepholidine is a potential medication for the research of opiate addiction ^[1] .

HY-119943A

(Rac)-PF-06256142	Dopamine Receptor	Neurological Disease
(Rac)-PF-06256142 is the less effective enantiomer of PF-06256142 (HY-119943). (Rac)-PF-06256142 is an agonist of D1 receptor, with an EC₅₀ of 107 nM. (Rac)-PF-06256142 can be used for the research of schizophrenia and Parkinson's disease ^[1].

HY-116874

SKF 83822 1 Publications Verification	Dopamine Receptor	Neurological Disease
SKF 83822 is an atypical agonist of dopamine D1 receptor. SKF 83822 activates adenylyl cyclase (AC), but not phospholipase C (PLC). SKF 83822 is also proved to stimulate AC via cAMP production. SKF 83822 can be used for research of schizophrenia ^[1] .

HY-103416

A-77636 hydrochloride 1 Publications Verification	Dopamine Receptor	Neurological Disease
A-77636 hydrochloride is a potent, orally active, selective and long acting dopamine D1 receptor agonist (pK_i=7.40; K_i=39.8 nM) with antiparkinsonian activity. A-77636 hydrochloride is functionally inactive at dopamine D2 receptor ^[1] .

HY-106889

Zelandopam free base YM435 free base	Dopamine Receptor	Others
Zelandopam free base (YM435 free base) is an orally active and selective agonist of the dopamine D1 receptor. Zelandopam free base possesses potent renal vasodilatory properties and can effectively alleviate cisplatin (HY-17394)-induced acute renal failure ^[1].

HY-120879

PF2562	Dopamine Receptor	Neurological Disease
PF2562 (Example 6), a dopamine D1 ligand, ascts as a dopamine D1 agonist or partial agonist. PF2562 binds to human D1 receptor with a K_i of 113 nM. PF2562 exhibits activity against human D1 cAMP with an EC₅₀ of 568 nM in HTRF assay ^[1].

HY-12987

Pimozide 4 Publications Verification R6238	Dopamine Receptor Adrenergic Receptor STAT Parasite	Neurological Disease Endocrinology Cancer
Pimozide is a dopamine receptor antagonist, with K_is of 1.4 nM, 2.5 nM and 588 nM for dopamine D2, D3 and D1 receptors, respectively, and also has affinity at *α1-adrenoceptor, with a K_i* of 39 nM; Pimozide also inhibits STAT3 and STAT5.

HY-110021

Fenoldopam hydrochloride SKF 82526 hydrochloride	Dopamine Receptor Histone Demethylase Apoptosis	Cardiovascular Disease Cancer
Fenoldopam (SKF 82526) hydrochloride is a D₁ receptor agonist and a novel lysine-specific demethylase 1 (LSD1) inhibitor (IC₅₀=0.8974 μM). Fenoldopam hydrochloride shows anti-hypertensive effects, anti-cancer cell proliferation activity and can induce cells apoptosis ^[1] .

HY-B0735A

Fenoldopam mesylate 4 Publications Verification Fenoldopam methanesulfonate; SKF-82526 mesylate	Dopamine Receptor Apoptosis	Cardiovascular Disease Cancer
Fenoldopam mesylate (SKF-82526) is a *D₁ receptor* agonist and a novel lysine-specific demethylase 1 (LSD1) inhibitor (IC₅₀=0.8974 μM). Fenoldopam mesylate shows anti-hypertensive effects, anti-cancer cell proliferation activity and can induce cells apoptosis ^[1] .

HY-19100

ADX-10061 CEE 03-310; NNC 687	Dopamine Receptor Adenylate Cyclase	Neurological Disease
ADX-10061 (compound NNC 687) is a dopamine D1 receptor antagonist with the K_i values of 9.1 nM, 5.8 nM, > 10 000 nM and 355 nM for adenylyl cyclase, D1, D2 and 5-HT₂ receptor, respectively. ADX-10061 can be used for study of schizophrenia ^[1].

HY-19733

Lumateperone tosylate ITI-007 tosylate	5-HT Receptor Dopamine Receptor	Neurological Disease Cancer
Lumateperone (ITI-007) tosylate is a 5-HT2A receptor antagonist (Ki = 0.54 nM), a partial agonist of presynaptic D2 receptors and an antagonist of postsynaptic D2 receptors (Ki = 32 nM), and a dopamine D1 receptor modulator. Lumateperone tosylate has anticancer activity and can also be used in studies of psychiatric disorders such as schizophrenia ^[1] .

HY-118956

Adrogolide hydrochloride ABT-431 hydrochloride; DAS-431 hydrochloride	Dopamine Receptor	Neurological Disease
Adrogolide hydrochloride (ABT-431 hydrochloride) is a chemically stable prodrug that can convert to the dopamine D1 receptor agonist A-86929. Adrogolide hydrochloride ameliorates the MPTP (HY-15608)-induced Parkinson's Disease in marmoset model, reduces the dyskinesias tendency. Adrogolide hydrochloride reverses Risperidone (HY-11018)-induced cognitive deficits in monkey ^[1].

HY-101299A

Dihydrexidine DAR-0100	Dopamine Receptor YAP	Neurological Disease
Dihydrexidine (DAR-0100) is a high potent, selective and full efficacy D1-like dopamine receptor (D1/D5) agonist with an IC₅₀ of 10 nM for D1 receptor. Dihydrexidine exhibits potent antiparkinsonian activity ^[1] . Dihydrexidine can stimulate YAP phosphorylation .

HY-101299B

Dihydrexidine hydrochloride 4 Publications Verification DAR-0100 hydrochloride	Dopamine Receptor	Neurological Disease
Dihydrexidine hydrochloride (DAR-0100 hydrochloride) is a high potent, selective and full efficacy D1-like dopamine receptor (D1/D5) agonist, with an IC₅₀ of 10 nM for D1 receptor. Dihydrexidine hydrochloride exhibits potent antiparkinsonian activity ^[1] . Dihydrexidine hydrochloride can stimulate YAP phosphorylation .

HY-17637

Lumateperone ITI-007	Dopamine Receptor 5-HT Receptor	Neurological Disease Cancer
Lumateperone (ITI-007) is an orally active 5-HT2A receptor antagonist (Ki = 0.54 nM), a partial agonist of presynaptic D2 receptors and an antagonist of postsynaptic D2 receptors (Ki = 32 nM), and a dopamine D1 receptor modulator. Lumateperone has anticancer activity and can also be used for the study of schizophrenia and bipolar depression ^[1] .

Cat. No.	Product Name	Target	Research Area

HY-P10405

TAT-D1 peptide	Dopamine Receptor	Neurological Disease
TAT-D1 peptide is a selective *D1-D2* heterogeneous antagonist. TAT-D1 peptide destroys the heterodimer of the *D1-D2* receptor by interacting with the specific domain of the D2 receptor through its unique amino acid sequence, in particular the two glutamate residues at the C terminal of the D1 receptor. TAT-D1 peptide can be used to study the role of *D1-D2* receptor heterodimers in the regulation of depressive and anxiety-like behaviors ^[1].

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N5140

Bacopaside X Bacopaside VII	Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Other Diseases Scrophulariaceae Plants Disease Research Fields Bacopa monnieri (Linn.) Wettst.	Dopamine Receptor
Bacopaside X is found in Bacopa monnieri, and shows a binding affinity toward the D1 receptor ^[1].

HY-N2003

D-Tetrahydropalmatine	Alkaloids Structural Classification Corydalis yanhusuo W. T. Wang Classification of Application Fields Source classification Metabolic Disease Plants Isoquinoline Alkaloids Disease Research Fields Papaveraceae	Dopamine Receptor
D-Tetrahydropalmatine is an isoquinoline alkaloid, mainly in the genus Corydalis ^[1]. D-Tetrahydropalmatine is a dopamine (DA) receptor antagonist with preferential affinity toward the D1 receptors . D-Tetrahydropalmatine is a potent organic cation transporter 1 (OCT1) inhibitor .

HY-N6960

L-Stepholidine Stepholidine; (-)-Stepholidine; L-SPD	Alkaloids Stephania intermedia Source classification Plants Isoquinoline Alkaloids Menispermaceae	Dopamine Receptor
L-Stepholidine (Stepholidine) exhibits mixed dopamine D1 receptor agonist and D2 antagonist properties. L-Stepholidine has neuroprotective effect and inhibits Heroin-induced reinstatement. L-Stepholidine is a potential medication for the research of opiate addiction ^[1] .

HY-N5140R

Bacopaside X (Standard)	Triterpenes Structural Classification Terpenoids Source classification Scrophulariaceae Plants Bacopa monnieri (Linn.) Wettst.	Dopamine Receptor
Bacopaside X (Standard) is the analytical standard of Bacopaside X. This product is intended for research and analytical applications. Bacopaside X is found in Bacopa monnieri, and shows a binding affinity toward the D1 receptor ^[1].

Cat. No.	Product Name	Chemical Structure

HY-12987S

Pimozide-d4
Pimozide-d₄ is a deuterium labeled Pimozide. Pimozide is a dopamine receptor antagonist, with Kis of 1.4 nM, 2.5 nM and 588 nM for dopamine D2, D3 and D1 receptors, respectively, and also has affinity at α1-adrenoceptor, with a Ki of 39 nM; Pimozide also inhibits STAT3 and STAT5[1][2][3].

HY-12987S2

Pimozide-d4-1
Pimozide-d₄-1 is the deuterium labeled Pimozide. Pimozide is a dopamine receptor antagonist, with Kis of 1.4 nM, 2.5 nM and 588 nM for dopamine D2, D3 and D1 receptors, respectively, and also has affinity at α1-adrenoceptor, with a Ki of 39 nM; Pimozide also inhibits STAT3 and STAT5[1][2][3][4].

HY-15394S1

(Rac)-Rotigotine-d3 hydrochloride

(Rac)-Rotigotine-d₃ hydrochloride is a deuterium labeled (Rac)-Rotigotine (hydrochloride) (HY-15394). (Rac)-Rotigotine hydrochloride is a racemate of Rotigotine. Rotigotine is a full agonist of dopamine receptor, a partial agonist of the 5-HT1A receptor, and an antagonist of the α2B-adrenergic receptor, with K_is of 0.71 nM, 4-15 nM, and 83 nM for the dopamine D3 receptor and D2, D5, D4 receptors, and dopamine D1 receptor.

HY-12987S1

Pimozide-d5 N-Oxide
Pimozide-d₅ N-Oxide is the deuterium labeled Pimozide. Pimozide is a dopamine receptor antagonist, with Kis of 1.4 nM, 2.5 nM and 588 nM for dopamine D2, D3 and D1 receptors, respectively, and also has affinity at α1-adrenoceptor, with a Ki of 39 nM; Pimozide also inhibits STAT3 and STAT5[1][2].

HY-B0623AS3

Ropinirole-d14 hydrochloride

Ropinirole-d₁₄ hydrochloride is deuterated labeled Ropinirole hydrochloride (HY-B0623A). Ropinirole (SKF 101468) hydrochloride is an orally active, potent D₃/D₂ receptor agonist with a K_i of 29 nM for D₂ receptor. Ropinirole hydrochloride has pEC₅₀s of 7.4, 8.4 and 6.8 for hD₂, hD₃ and hD₄ receptors, respectively. Ropinirole hydrochloride has no affinity for the D₁ receptors. Ropinirole hydrochloride has the potential for Parkinson's disease ^[1] .

HY-B0623AS1

Ropinirole-d7 hydrochloride

Ropinirole-d₇ (hydrochloride) is the deuterium labeled Ropinirole hydrochloride[1]. Ropinirole (SKF 101468) hydrochloride is an orally active, potent D3/D2 receptor agonist with a Ki of 29 nM for D2 receptor. Ropinirole hydrochloride has pEC50s of 7.4, 8.4 and 6.8 for hD2, hD3 and hD4 receptors, respectively. Ropinirole hydrochloride has no affinity for the D1 receptors. Ropinirole hydrochloride has the potential for Parkinson's disease[2][3].

HY-B0623AS2

Ropinirole-d3 hydrochloride

Ropinirole-d₃ (hydrochloride) is the deuterium labeled Ropinirole hydrochloride[1]. Ropinirole (SKF 101468) hydrochloride is an orally active, potent D3/D2 receptor agonist with a Ki of 29 nM for D2 receptor. Ropinirole hydrochloride has pEC50s of 7.4, 8.4 and 6.8 for hD2, hD3 and hD4 receptors, respectively. Ropinirole hydrochloride has no affinity for the D1 receptors. Ropinirole hydrochloride has the potential for Parkinson's disease[2][3].

HY-15394S

(Rac)-Rotigotine-d7 hydrochloride

(Rac)-Rotigotine-d₇ (hydrochloride) is deuterium labeled (Rac)-Rotigotine (hydrochloride). (Rac)-Rotigotine hydrochloride is a racemate of Rotigotine. Rotigotine is a full agonist of dopamine receptor, a partial agonist of the 5-HT1A receptor, and an antagonist of the α2B-adrenergic receptor, with Kis of 0.71 nM, 4-15 nM, and 83 nM for the dopamine D3 receptor and D2, D5, D4 receptors, and dopamine D1 receptor.

HY-19733S

Lumateperone-13C,d3 tosylate

Lumateperone- ¹³C,d₃ (ITI-007- ¹³C,d₃) tosylate is ¹³C and deuterium labeled Lumateperone (tosylate). Lumateperone (ITI-007) tosylate is a 5-HT2A receptor antagonist (Ki = 0.54 nM), a partial agonist of presynaptic D2 receptors and an antagonist of postsynaptic D2 receptors (Ki = 32 nM), and a dopamine D1 receptor modulator. Lumateperone tosylate has anticancer activity and can also be used in studies of psychiatric disorders such as schizophrenia ^[1] .

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