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Results for "

Embryonic

" in MedChemExpress (MCE) Product Catalog:

122

Inhibitors & Agonists

3

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4

Fluorescent Dye

2

Biochemical Assay Reagents

14

Peptides

4

MCE Kits

1

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9

Natural
Products

5

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2

Isotope-Labeled Compounds

2

Antibodies

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-103073
    Mesendogen

    		TRP Channel Others
    Mesendogen is a TRPM6 inhibitor. Mesendogen enhances the mesoderm and definitive endoderm (DE) differentiations of human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs). Mesendogen can be used for the research of magnesium homeostasis during early embryonic cell development .
    Mesendogen
  • HY-E70098
    RNase H2

    		Others Cancer
    RNase H2 is the predominant source of RNase H activity in mammalian and human cells. RNase H2 protects genome integrity. RNase H2 has been associated with ribonucleotide removal from genomic DNA in yeast and mouse, where it is required for embryonic development .
    RNase H2
  • HY-136977
    EEDi-5285

    		Histone Methyltransferase Cancer
    EEDi-5285 is an exceptionally potent and orally active embryonic ectoderm development (EED) inhibitor with an IC50 value of 0.2 nM for binds to the EED protein. EEDi-5285 has anti-cancer activity .
    EEDi-5285
  • HY-123464
    RBC10

    		Ras Cancer
    RBC10 is an anti-cancer agent. RBC10 inhibits the binding of Ral to its effector RALBP1. RBC10 also inhibits Ral-mediated cell spreading of murine embryonic fibroblasts and anchorage-independent growth of human cancer cell lines .
    RBC10
  • HY-125987
    RBC6

    		Others Ras Cancer
    RBC6 is an inhibitor of GTPases RalA. RBC6 inhibits binding of Ral to its effector RALBP1. RBC6 also inhibits Ral-mediated cell spreading of murine embryonic fibroblasts, as well as anchorage-independent growth of human cancer celllines .
    RBC6
  • HY-124838
    EG1

    		Others Cancer
    EG1, a specific Pax2 inhibitor, directly binds the paired domain of Pax2 (Kd=1.35-1.5 μM) and inhibits Pax2-DNA interactions. EG1 can inhibit embryonic kidney development, a process directly dependent on Pax2 activity .
    EG1
  • HY-114638A
    Diproteverine hydrochloride

    BRL 40015 hydrochloride

    		 Calcium Channel Cardiovascular Disease
    Diproteverine hydrochloride is an oral activity calcium channel blocker. Diproteverine hydrochloride embryonic toxicity. Diproteverine hydrochloride also shows antianginal properties .
    Diproteverine hydrochloride
  • HY-114638
    Diproteverine

    BRL 40015

    		 Calcium Channel Cardiovascular Disease
    Diproteverine (BRL 40015) is an oral activity calcium channel blocker. Diproteverine embryonic toxicity. Diproteverine also shows antianginal properties .
    Diproteverine
  • HY-P10706
    Ac-ILVAGK-NH2

    		Biochemical Assay Reagents Others
    Ac-ILVAGK-NH2 is a self-assembling peptide that helps human H1 embryonic stem cells maintain their pluripotency .
    Ac-ILVAGK-NH2
  • HY-103663A
    MAK683 hydrochloride

    		Histone Methyltransferase Cancer
    MAK683 hydrochloride is an embryonic ectoderm development (EED) inhibitor extracted from patent US20160176882 A1, compound example 2. MAK683 exhibits IC50s of 59, 89, 26 nM in EED Alphascreen binding, LC-MS and ELISA assay .
    MAK683 hydrochloride
  • HY-139400A
    Pociredir hydrochloride

    FTX-6058 hydrochloride

    		 Histone Methyltransferase Cardiovascular Disease
    Pociredir (FTX-6058) hydrochloride is a potent and orally active inhibitor of Embryonic Ectoderm Development (EED). Pociredir hydrochloride can induce HbF protein expression in cell and murine models. Pociredir hydrochloride can be used for the research of select hemoglobinopathies, including sickle cell disease and β-thalassemia .
    Pociredir hydrochloride
  • HY-139400
    Pociredir

    FTX-6058

    		 Histone Methyltransferase Cardiovascular Disease
    Pociredir (FTX-6058) is a potent and orally active inhibitor of Embryonic Ectoderm Development (EED). Pociredir can induce HbF protein expression in cell and murine models. Pociredir can be used for the research of select hemoglobinopathies, including sickle cell disease and β-thalassemia .
    Pociredir
  • HY-116057
    Stemazole

    		Apoptosis Others
    Stemazole is a protective agent that promotes stem cell survival. Stemazole has the protective effect of human embryonic stem cells (hESCs). Stemazole enhances clonal expansion of single cells and decreases apoptosis. Stemazole for the study of stem cell survival in starvation culture .
    Stemazole
  • HY-P3138
    (Sar1)-Angiotensin II

    		Angiotensin Receptor Cardiovascular Disease
    (Sar1)-Angiotensin II, an analogue of Angiotensin II, is a specific agonist of angiotensin AT1 receptor. (Sar1)-Angiotensin II binds to brain membrane-rich particles, with a Kd of 2.7 nM. (Sar1)-Angiotensin II can stimulate protein synthesis and cell growth in embryonic chick myocytes .
    (Sar1)-Angiotensin II
  • HY-W178327
    8-Chloro caffeine

    		Adenosine Receptor Cancer
    8-Chloro caffeine binds to adenosine receptors (Ki = 30 µM). 8-Chloro caffeine potentiates UV-induced chromosomal aberrations in Cl-I Chinese hamster embryonic lung cells. 8-Chloro caffeine is a derivative of the methylxanthine alkaloid caffeine .
    8-Chloro caffeine
  • HY-P5891
    TAT-SAMβA

    		PKC Cardiovascular Disease
    TAT-SAMβA is the peptide consist of RNAENFDRF (SAMβA; HY-P3429) conjugated to the cell penetrating TAT protein-derived peptide TAT47–57. TAT-SAMβA is a selective antagonist of Mfn1-βIIPKC association. TAT-SAMβA protects mouse embryonic fibroblast cells (MEFs) against oxidative stress-induced cytotoxicity .
    TAT-SAMβA
  • HY-130815
    MAK683-CH2CH2COOH

    		Histone Methyltransferase Ligands for Target Protein for PROTAC Cancer
    MAK683-CH2CH2COOH binds to EED (embryonic ectoderm development protein). MAK683-CH2CH2COOH and a VHL ligand for the E3 ubiquitin ligase have been used to design PROTAC EED degrader-1 (HY-130614) and PROTAC EED degrader-2 (HY-130615) .
    MAK683-CH2CH2COOH
  • HY-130815A
    MAK683-CH2CH2COOH hydrochloride

    		Ligands for Target Protein for PROTAC Histone Methyltransferase Cancer
    MAK683-CH2CH2COOH binds to EED (embryonic ectoderm development protein). MAK683-CH2CH2COOH and a VHL ligand for the E3 ubiquitin ligase have been used to design PROTAC EED degrader-1 (HY-130614) and PROTAC EED degrader-2 (HY-130615) .
    MAK683-CH2CH2COOH hydrochloride
  • HY-Y0278
    Chloranil

    Tetrachloro-p-benzoquinone; TCBQ

    		 Toll-like Receptor (TLR) MyD88 Apoptosis Ferroptosis JNK Fungal Reactive Oxygen Species Infection Neurological Disease Metabolic Disease Inflammation/Immunology
    Chloranil (Tetrachloro-p-benzoquinone), an orally active metabolite of pentachlorophenol and hexachlorobenzene, is a widely used fungicide. Chloranil can induce ROS production. Chloranil induces neutrophil extracellular traps through the ROS-JNK-NOX2 pathway. Chloranil induces ferroptosis and neuroinflammation. Chloranil induces apoptosis of mouse embryonic stem cells .
    Chloranil
  • HY-15838
    ID-8
    4 Publications Verification

    		 DYRK Cancer
    ID-8 is an inhibitor of dual-specificity tyrosine phosphorylation-regulated kinase (DYRK). ID-8 sustains embryonic stem cell (ESC) self-renewal and pluripotency. ID-8 enhances Wnt-mediated hESC survival and proliferation via inhibition of DYRKs .
    ID-8
  • HY-D1427
    Di-2-ANEPEQ

    		Fluorescent Dye Neurological Disease
    Di-2-ANEPEQ is a voltage sensitive membrane potential fluorescence dye. Di-2-ANEPEQ can be used for the evaluation of voltage-sensitive fluorescence dyes for monitoring neuronal activity in the embryonic central nervous system .
    Di-2-ANEPEQ
  • HY-Y0278R
    Chloranil (Standard)

    Tetrachloro-p-benzoquinone (Standard); TCBQ (Standard)

    		 Toll-like Receptor (TLR) MyD88 Apoptosis Ferroptosis JNK Reactive Oxygen Species Fungal Infection Neurological Disease Metabolic Disease Inflammation/Immunology
    Chloranil (Standard) is the analytical standard of Chloranil. This product is intended for research and analytical applications. Chloranil, an orally active metabolite of pentachlorophenol and hexachlorobenzene, is a widely used fungicide. Chloranil can induce ROS production. Chloranil induces neutrophil extracellular traps through the ROS-JNK-NOX2 pathway. Chloranil induces ferroptosis and neuroinflammation. Chloranil induces apoptosis of mouse embryonic stem cells .
    Chloranil (Standard)
  • HY-B1374S1
    Florfenicol-d3

    (-)-Florfenicol-d3; SCH-25298-d3

    		 Isotope-Labeled Compounds Bacterial Antibiotic Infection
    Florfenicol-d3 is the deuterium labeled Florfenicol. Florfenicol, a commonly used veterinary antibiotic, is currently indicated for bovine respiratory disease, and also used in aquaculture for the control of enteric septicemia in catfish. Florfenicol can induce early embryonic death in eggs, with an LC50 of 1.07 μg/g.
    Florfenicol-d3
  • HY-13306
    Pyrintegrin
    4 Publications Verification

    		 Integrin Metabolic Disease
    Pyrintegrin is an β1-integrin agonist and a 2,4-disubstituted pyrimidine that promotes embryonic stem cells survival. Pyrintegrin enhances cell-extracellular matrix (ECM) adhesion-mediated integrin signaling. Pyrintegrin can be used as a podocyte-protective agent and has robustly adipogenic .
    Pyrintegrin
  • HY-107408
    SANT 2

    		Hedgehog Cancer
    SANT 2 is a potent antagonist of Hh-signaling pathway. Hedgehog (Hh) signaling plays an important role in cell signaling of embryonic development and adult tissue homeostasis. SANT 2 has the potential for the research of several malignancies including Gorlin syndrome (a disorder predisposing to basal cell carcinoma, medulloblastoma and rhabdomyosarcoma), prostate, pancreatic and breast cancers .
    SANT 2
  • HY-116603
    SB-236057

    		5-HT Receptor Others
    SB-236057 is an inverse agonist of the 5-HT1B receptor that exhibits strong skeletal teratogenicity in rodents and rabbits. SB-236057 affects gene expression during embryonic development through interference with the Notch signaling pathway and interaction with r-esp1. SB-236057 induces somatic patterning and tail extension defects in rat embryos during early organogenesis .
    SB-236057
  • HY-114858
    Epiblastin A

    		Casein Kinase Cancer
    Epiblastin A is an ATP competitive casein kinase 1 (CK1) inhibitor with IC50s of 8.9, 0.5, and 4.7 µM for CK1α, CK1δ, and CK1 ɛ, respectively. Epiblastin A induces reprogramming of epiblast stem cells into embryonic stem cells by inhibition of CK1 .
    Epiblastin A
  • HY-100368
    MELK-8a
    3 Publications Verification

    NVS-MELK8a

    		 MELK PDGFR Haspin Kinase Cancer
    MELK-8a (NVS-MELK8a) is a highly potent and selective maternal embryonic leucine zipper kinase (MELK) inhibitor with IC50 of 2 nM. MELK-8a also inhibits Flt3 (ITD), Haspin, PDGFRα with IC50s of 0.18, 0.19, and 0.42 μM, respectively. MELK plays an essential role in regulating cell mitosis in a subset of cancer cells .
    MELK-8a
  • HY-W025074
    BML-278

    		Sirtuin Histone Methyltransferase Cancer
    BML-278 is a SIRT1 activator (EC150: 1 μM). BML-278 increases H3K9 methylation and inhibits H3K9 acetylation in both the paternal and maternal pronucleus. BML-278 improves early embryonic development. BML-278 arrests the cell cycle at the G1/S phase, and reduces senescence in primary human mesenchymal cells. BML-278 reduces tubulin acetylation in U937 cells. BML-278 also increases mitochondrial density in murine C2C12 myoblasts .
    BML-278
  • HY-12564
    Phthalazinone pyrazole

    		Aurora Kinase Apoptosis Cancer
    Phthalazinone pyrazole is a potent, selective, and orally active inhibitor of Aurora-A kinase with an IC50 of 0.031 μM. Phthalazinone pyrazole can arrests mitosis and subsequently inhibit tumor growth via apoptosis of proliferating cells. Phthalazinone pyrazole suppresses the epithelial-mesenchymal transition (EMT) during the differentiation of hepatocyte-like cells (HLCs) from human embryonic stem cells .
    Phthalazinone pyrazole
  • HY-W762011
    BDE 47

    		Apoptosis Reactive Oxygen Species JNK Oxidative Phosphorylation Neurological Disease Cancer
    BDE 47 targets mitochondria, inhibits mitochondrial oxidative phosphorylation (OXPHOS), decreases mitochondrial membrane potential (MMP) and induces apoptosis in embryonic cell. BDE 47 induces the generation of ROS, and activates the JNK signaling pathway. BDE 47 exhibits embryonic developmental toxicity in zebrafish .
    BDE 47
  • HY-100368A
    MELK-8a hydrochloride
    3 Publications Verification

    NVS-MELK8a hydrochloride

    		 MELK Cancer
    MELK-8a hydrochloride is a novel maternal embryonic leucine zipper kinase (MELK) inhibitor with an IC50 of 2 nM.
    MELK-8a hydrochloride
  • HY-13257
    Thiazovivin
    5 Publications Verification

    		 ROCK Cancer
    Thiazovivin is a potent ROCK inhibitor, which can protect human embryonic stem cells. Thiazovivin improves the efficiency of iPSC generation.
    Thiazovivin
  • HY-101515
    MELK-IN-1

    		MELK Cancer
    MELK-IN-1 is a potent inhibitor of maternal embryonic leucine zipper kinase (MELK) with an IC50 and a Ki of 3 nM and 0.39 nM, respectively.
    MELK-IN-1
  • HY-W762011R
    BDE 47 (Standard)

    		Apoptosis Reactive Oxygen Species JNK Oxidative Phosphorylation Neurological Disease Cancer
    BDE 47 (Standard) is the analytical standard of BDE 47. This product is intended for research and analytical applications. BDE 47 targets mitochondria, inhibits mitochondrial oxidative phosphorylation (OXPHOS), decreases mitochondrial membrane potential (MMP) and induces apoptosis in embryonic cell. BDE 47 induces the generation of ROS, and activates the JNK signaling pathway. BDE 47 exhibits embryonic developmental toxicity in zebrafish .
    BDE 47 (Standard)
  • HY-100534
    IDE 2

    		Organoid TGF-beta/Smad Others
    IDE2 is a small molecule cell-permeable inducer of definitive endoderm formation in mouse and human embryonic stem cells (ESCs) by activating the TGF-βsignaling pathway .
    IDE 2
  • HY-111002
    Displurigen

    NSC375009

    		 HSP Others
    Displurigen (NSC375009) disrupts human embryonic stem cell pluripotency by targeting HSPA8. Displurigen inhibits ATPase activity of HSP70 (IC50 = 225 μM) .
    Displurigen
  • HY-17597
    Febantel

    		Parasite Infection
    Febantel is an oral dewormer used to treat gastrointestinal nematodes in sheep, as well as roundworm and tapeworm infections in poultry and livestock, and it also inhibits the embryonic development of mouse hairworms and whipworm eggs .
    Febantel
  • HY-N2785
    Desmethylicaritin

    		Wnt Metabolic Disease
    Desmethylicaritin is a phytoestrogenic molecule, has inducible effect on directional differentiation of embryonic stem cells into cardiomyocytes. Desmethylicaritin also suppresses adipogenesis via Wnt/β-catenin signaling pathway .
    Desmethylicaritin
  • HY-123696
    CDy9

    		Fluorescent Dye Others
    CDy9 is a highly selective fluorescent probe. CDy9 can be used to detect mouse embryonic stem cells. ( λ exc. / λ em.：563 nm/578 nm) .
    CDy9
  • HY-130708
    UNC6852
    2 Publications Verification

    		 Histone Methyltransferase PROTACs Cancer
    UNC6852 is a selective polycomb repressive complex 2 (PRC2) degrader based on PROTAC and contains an EED (embryonic ectoderm development) ligand and a von Hippel-Lindau ligand, with an IC50 of 247 nM for EED .
    UNC6852
  • HY-P10858
    UCI-1

    		SARS-CoV Virus Protease Infection
    UCI-1 is a SARS-CoV-2 main protease (M pro) cyclic peptide inhibitor with an IC50 of 160 μM. UCI-1 shows no obvious cytotoxicity at the concentration of inhibiting M pro. UCI-1 can be used in the study of anti-COVID-19 drugs .
    UCI-1
  • HY-18330
    MI 63

    		MDM-2/p53 Cancer
    MI 63 is an activator for p53, by targeting the MDM2 (Ki is 3 nM). MI 63 inhibits the proliferation of embryonic and alveolar rhabdomyosarcoma (ERMS and ARMS) cells (IC50 is 0.58 μM in RH36 cells), and induces apoptosis in ERMS and ARMS .
    MI 63
  • HY-N6747
    Stauprimide

    		c-Myc Autophagy Cancer
    Stauprimide is a staurosporine analog that promotes embryonic stem cell (ESC) differentiation. Stauprimide is a non-broad spectrum inhibitor that binds to the MYC transcription factor NME2 and blocks its nuclear localization in ESCs, which results in down-regulation of MYC transcription .
    Stauprimide
  • HY-135146
    GSK-3484862
    10+ Cited Publications

    		 DNA Methyltransferase Cancer
    GSK-3484862 is a non-covalent inhibitor for DNA methyltransferase (Dnmt1). GSK-3484862 induces DNA hypomethylation to against cancer. GSK-3484862 mediates dramatic demethylation in murine embryonic stem cells with minimal non-specific toxicity .
    GSK-3484862
  • HY-156095
    F7H

    		Wnt Cancer
    F7H is a Frizzled receptor FZD7 antagonist (IC50: 1.25 μM). Frizzled receptors (FZDs) influence Wnt signaling, mediating embryonic development and tissue homeostasis. F7H is a potent ligand for the FZD7 transmembrane domain (TMD) .
    F7H
  • HY-103663
    MAK683
    2 Publications Verification

    		 Histone Methyltransferase Cancer
    MAK683 is an embryonic ectoderm development (EED) inhibitor extracted from patent US20160176882 A1, compound example 2. MAK683 exhibits IC50s of 59, 89, 26 nM in EED Alphascreen binding, LC-MS and ELISA assay .
    MAK683
  • HY-N7122
    Thymopentin

    		Endogenous Metabolite Inflammation/Immunology Cancer
    Thymopentin is a biologically active peptide secreted mainly by the epithelial cells of thymic cortex and medulla. Thymopentin is an effective immunomodulatory agent with a short plasma half-life of 30 seconds. Thymopentin enhances the generation of T-cell lineage derived from human embryonic stem cells (hESCs) .
    Thymopentin
  • HY-N7122A
    Thymopentin acetate

    		Endogenous Metabolite Inflammation/Immunology Cancer
    Thymopentin acetate is a biologically active peptide secreted mainly by the epithelial cells of thymic cortex and medulla. Thymopentin acetate is an effective immunomodulatory agent with a short plasma half-life of 30 seconds. Thymopentin acetate enhances the generation of T-cell lineage derived from human embryonic stem cells (hESCs) .
    Thymopentin acetate
  • HY-146385
    hCAI/II-IN-1

    		Carbonic Anhydrase Cancer
    hCAI/II-IN-1 (Compound 3h) is a human carbonic anhydrase I and II (hCA I/II) inhibitor with IC50 values of 0.047 µM and 0.024 µM against hCA I and hCA II, respectively .
    hCAI/II-IN-1

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