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Results for "

GPX4

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (1) Apoptosis (10) Autophagy (1) Bcl-2 Family (2) Caspase (2) CDK (1) COX (2) Drug Isomer (1) EGFR (1) Endogenous Metabolite (3) Ferroptosis (54) Glutathione Peroxidase (41) IFNAR (1) Interleukin Related (1) Isotope-Labeled Compounds (1) JNK (2) Keap1-Nrf2 (2) Ligands for E3 Ligase (1) MDM-2/p53 (3) Microtubule/Tubulin (1) Mitochondrial Metabolism (1) mTOR (1) p62 (1) PARP (1) PI3K (1) Prostaglandin Receptor (2) PROTAC Linkers (1) PROTACs (7) Pyroptosis (1) Reactive Oxygen Species (12) Small Interfering RNA (siRNA) (1) STAT (1) STING (1) TrxR (1) YAP (3)
By Research Areas:	Cancer (55) Cardiovascular Disease (3) Endocrinology (2) Infection (2) Inflammation/Immunology (8) Metabolic Disease (3) Neurological Disease (6)
Click Chemistry:	Azide (1) Alkynes (2)
Oligonucleotides:	Human Pre-designed siRNA Sets (1) siRNAs (1)

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Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-161929

GPX4 activator 2	Glutathione Peroxidase Ferroptosis	Cardiovascular Disease
GPX4 activator 2 (Compound C3) is an activator of *GPX4. GPX4* activator 2 exhibits cardioprotective effects and can inhibit cellular ferroptosis (EC₅₀ = 7.8 μM)。GPX4 activator 2 can be used in the research of myocardial injury .

HY-141809

GPX4-IN-3 2 Publications Verification	Glutathione Peroxidase Ferroptosis	Cancer
GPX4-IN-3 (26a) is a potent glutathione peroxidase 4 (GPX4) inhibitor as a selective ferroptosis inducer. GPX4-IN-3 (26a) exhibits 71.7% inhibition for GPX4 with 1 μM .

HY-138556

GPX4-IN-2	Glutathione Peroxidase	Cancer
GPX4-IN-2 is a potent *GPX4* inhibitor. GPX4 shows antiproliferative activity. GPX4-IN-2 has the potential for the research of cancer .

HY-161928

GPX4 activator 1	Glutathione Peroxidase Ferroptosis	Cancer
GPX4 activator 1 (Compound A9) is a allosteric activator of *GPX4* (K_d = 5.86 μM, EC₅₀ = 19.19 μM). GPX4 activator 1 can selectively act on ferroptosis and prevent the accumulation of intracellular lipid peroxides caused by ferroptosis inducers .

HY-RS05767

GPX4 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
GPX4 Human Pre-designed siRNA Set A contains three designed siRNAs for GPX4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

GPX4 Human Pre-designed siRNA Set A GPX4 Human Pre-designed siRNA Set A

HY-163272

GPX4/CDK-IN-1	Glutathione Peroxidase CDK	Cancer
GPX4/CDK-IN-1 (Compound B9) is a dual inhibitor of *GPX4* and CDK, with IC₅₀ values of 542.5 nM, 191.2 nM and 68.1 nM for GPX4, CDK4 and CDK6, reapectively. GPX4/CDK-IN-1 shows strong cancer cell growth inhibition in vivo .

HY-163995

GPX4-IN-13	Ferroptosis Glutathione Peroxidase	Cancer
GPX4-IN-13 (compound 16) is a *GPX4* inhibitor with anticancer activity. GPX4-IN-13 reduces thyroid cell proliferation and induces ferroptosis by inhibiting the expression level of *GPX4. GPX4*-IN-13 inhibits the growth of three thyroid cancer cell lines: N-thy-ori-3-1 (IC₅₀=8.39 μM), MDA-T32 (IC₅₀=10.28 μM) and MDA-T41 (IC₅₀=8.18 μM) .

HY-156286

GPX4-IN-7	Ferroptosis	Cancer
GPX4-IN-7 (Compound 31), indirubin derivative, is a ferroptosis inducer for colon cancer. GPX4-IN-7 has strong antitumor activity against HCT-116 cells with an IC₅₀ value of 0.49 μM. GPX4-IN-7 can promote the degradation of GPX4, causing the accumulation of lipid ROS to induce ferroptosis .

HY-168879

GPX4-IN-16	Glutathione Peroxidase	Cancer
GPX4-IN-16 ((R)-9i) is a potent *GPX4* inhibitor with an K_D value of 20.4 nM. GPX4-IN-16 shows cytotoxicity. GPX4-IN-16 shows anticancer activity .

HY-149455

GPX4-IN-8	Glutathione Peroxidase	Cancer
GPX4-IN-8 (compound A80) is a potent *GPX4* inhibitor. GPX4-IN-8 shows antiproliferative activity .

HY-149923

GPX4-IN-4	Glutathione Peroxidase	Cancer
GPX4-IN-4 (Compound 24) is a potent *GPX4* inhibitor. GPX4-IN-4 can be used for the research of cancer .

HY-162717

GPX4-IN-11	Glutathione Peroxidase Ferroptosis	Cancer
GPX4-IN-11 (compound I14) is a potent inhibitor of *GPX4, with the K_D* of 45.7 μM. GPX4-IN-11 plays an important role in ferroptosis research .

HY-162718

GPX4-IN-12	Ferroptosis	Cancer
GPX4-IN-12 (compound I22) is a non-covalent *GPX4* inhibitor. GPX4-IN-12 induces ferroptosis and inhibits cell growth of HT1080 cells .

HY-162716

GPX4-IN-10	Ferroptosis	Cancer
GPX4-IN-10 (compound I20) is a non-covalent *GPX4* inhibitor. GPX4-IN-10 induces ferroptosis and inhibits cell growth of HT1080 cells .

HY-157762

GPX4-IN-9	Glutathione Peroxidase Ferroptosis	Cancer
GPX4-IN-9 (Compound A16) is a glutathione peroxidase 4 (GPX4) inhibitor that specifically targets *GPX4* under both in vitro and in vivo conditions, inducing ferroptosis. GPX4-IN-9 exhibits cytotoxicity against pancreatic cancer cells and can be used in cancer research .

HY-159990

GPX4-IN-15	Glutathione Peroxidase	Cancer
GPX4-IN-15 (Compound C1) is an inhibitor for *GPX4, that inhibits 19.8% GPX4* at 1 μM. GPX4-IN-15 inhibits the proliferation of cancer cell MDA-MB-468, BT-549 and MDA-MB-231 with IC₅₀ of 0.86, 0.96 and 0.48 μM .

HY-155664

GPX4-IN-6	Glutathione Peroxidase Ferroptosis	Cancer
GPX4-IN-6 (Compound C25) is a *GPX4* covalent inhibitor with an IC₅₀ value of 0.13 μM. GPX4-IN-6 (Compound C25) can induce ferroptosis for the research of triple-negative breast cancer (TNBC) .

HY-155663

GPX4-IN-5	Glutathione Peroxidase Ferroptosis	Cancer
GPX4-IN-5 (Compound C18) is a *GPX4* covalent inhibitor with an IC₅₀ value of 0.12 μM. GPX4-IN-5 (Compound C18) can induce ferroptosis for the research of triple-negative breast cancer (TNBC) .

HY-168011

GPX4-IN-14	Ferroptosis Glutathione Peroxidase Reactive Oxygen Species	Cancer
GPX4-IN-14 (compound 2c) is an inhibitor of *GPX4, with free radical scavenging activity (maximum scavenging rate is 72.52%) and anti-tumor proliferation activity in vitro. GPX4-IN-14 inhibits GPX4* protein, increases lipid peroxide levels and intracellular Reactive Oxygen Species (ROS) levels, thereby inducing ferroptosis and exerting anti-tumor proliferation effects .

HY-115627

PKUMDL-LC-101-D04 2 Publications Verification GPX4-Activator-1d4	Glutathione Peroxidase	Inflammation/Immunology
PKUMDL-LC-101-D04 (GPX4-Activator-1d4) is a glutathione peroxidase 4 *(GPX4)* allosteric activator (pEC₅₀=4.7). PKUMDL-LC-101-D04 can inhibit ferroptosis and inflammation .

HY-161930

*PROTAC GPX4* degrader-3**	PROTACs Ferroptosis	Cancer
PROTAC GPX4 degrader-3 is a potent PROTAC *GPX4* degrader with a DC₅₀ (24h) of 0.019 μM and an IC₅₀ of 0.024 μM in HT1080 cell .

HY-149236

*PROTAC GPX4* degrader-1**	PROTACs Glutathione Peroxidase Ferroptosis	Cancer
PROTAC GPX4 degrader-1 (DC-2) is a PROTAC-based *GPX4* degrader, with a DC₅₀ of 0.03 μM in HT1080 cells .

HY-162106

*PROTAC GPX4* degrader-2**	Ferroptosis PROTACs Glutathione Peroxidase	Cancer
PROTAC GPX4 degrader-2 (compound 18a) is a proteolysis targeting chimeras (PROTACs) that can degrade glutathione peroxidase 4 (GPX4), with the DC_{50, 48h} value of 1.68 μM. PROTAC GPX4 degrader-2 induces the accumulation of lipid peroxides and mitochondrial depolarization, subsequently triggering ferroptosis. PROTAC GPX4 degrader-2 has anti-proliferative effect .

HY-100003

ML-210 10+ Cited Publications	Glutathione Peroxidase Ferroptosis	Cancer
ML-210 is a selective and covalent glutathione peroxidase 4 (GPX4) inhibitor with an EC₅₀ of 30 nM. ML-210 binds the GPX4 selenocysteine residue. ML-210 has anti-cancer activity .

HY-103087

FIN56 10+ Cited Publications	Ferroptosis	Others
FIN56 is a specific inducer of ferroptosis. FIN56 induces ferroptosis by inducing degradation of GPX4. FIN56 also binds to and activates squalene synthase .

HY-100002

ML162 5+ Cited Publications	Glutathione Peroxidase Ferroptosis	Cancer
ML162 is a covalent glutathione peroxidase 4 (GPX4) inhibitor. ML162 has a selective lethal effect on mutant RAS oncogene-expressing cell lines

HY-139001

JKE-1716	Glutathione Peroxidase Ferroptosis	Others
JKE-1716 is a potent and selective nitrolic acid-containing *GPX4* inhibitor. JKE-1716 is able of inducing ferroptosis selectively through covalent *GPX4* inhibition .

HY-129457

FINO2 5 Publications Verification	Ferroptosis	Cancer
FINO2 is a potent ferroptosis inducer. FINO2 inhibits GPX4 activity. FINO2 is a stable oxidant that oxidizes ferrous iron and stable at varying pH levels. FINO2 causes widespread lipid peroxidation .

HY-157068

icFSP1	Ferroptosis Glutathione Peroxidase	Cancer
icFSP1 is a potent ferroptosis suppressor protein-1 (FSP1) inhibitor. icFSP1 triggers subcellular relocalization of FSP1 from the membrane and FSP1 condensation, in synergism with *GPX4* inhibition. icFSP1 induces ferroptosis. icFSP1 shows antitumor activity against melanoma. .

HY-169133

GDCNF-11	PROTACs Glutathione Peroxidase Ferroptosis	Cancer
GDCNF-11 is a HIM-PROTAC GPX4 degrader based on the chaperone protein HSP90. GDCNF-11 promotes the ubiquitination and degradation of *GPX4* through the HSP 90 chaperone complex, reduces endogenous *GPX4* expression to induce ferroptosis in HT-1080 cells, and the DC₅₀ value is 0.08 μM (Pink: Target protein ligand (HY-153748); Blue: HSP90 ligand (HY-10212); Black: Linker (HY-W169526)) .

HY-155852

Lepadin H	Ferroptosis	Others
Lepadin H is a marine alkaloid and ferroptosis inducer. Lepadin H exhibits significant cytotoxicity, promotes p53 expression, increases ROS production and lipid peroxidation, decreases SLC7A11 and GPX4 levels, and upregulates ACSL4 expression. Lepadin H induces ferroptosis through the p53-SLC7A11-GPX4 pathway .

HY-155952

LOC1886	Glutathione Peroxidase	Cancer
LOC1886 is a covalent inhibitor of *GPX4* with slightly lower potency than RSL3 and ML162 .

HY-162065

N6F11	Ferroptosis	Cancer
N6F11 is a selective ferroptosis inducer, and can selectively induce ferroptosis by targeting TRIM25-mediated *GPX4* degradation in cancer cells while sparing immune cells. N6F11 initiates HMGB1-dependent antitumor immunity mediated by CD8 ⁺ T cells ^[4].

HY-155851

Lepadin E	Ferroptosis MDM-2/p53 Glutathione Peroxidase	Cancer
Lepadin E is a significantly cytotoxic ferroptosis inducer that induces iron death through the classical p53-SLC7A11-GPX4 pathway. Lepadin E promoted p53 expression, decreases SLC7A11 and GPX4 levels, and leads to increased ROS and lipid peroxide production, and upregulated ACSL4 expression, thus causes cell death. Lepadin E has significant antitumor effect .

HY-N0070

Solasonine 2 Publications Verification	Ferroptosis Glutathione Peroxidase Reactive Oxygen Species	Cancer
Solasonine is a ferroptosis inducer which can be isolated from Solanum melongena that has anti-infection, anti-cancer, and neurogenesis promoting properties. Solasonine promotes ferroptosis of HCC cells via destruction of the glutathione redox system induced by inhibiting GPX4, and can be used for cancer research .

HY-100218A

RSL3 Maximum Cited Publications 287 Publications Verification (1S,3R)-RSL3	p62 Glutathione Peroxidase Ferroptosis Reactive Oxygen Species	Cancer
RSL3 ((1S,3R)-RSL3) is an inhibitor of glutathione peroxidase 4 (GPX4) (ferroptosis activator), reduces the expression of GPX4 protein, and induces ferroptotic death of head and neck cancer cell. RSL3 increases the expression of p62 and Nrf2 and inactivates Keap1 in HN3-rslR cells .

HY-120912

Gingerenone A	Keap1-Nrf2 Glutathione Peroxidase Ferroptosis	Metabolic Disease Inflammation/Immunology Cancer
Gingerenone A is an Nrf2-Gpx4 activator that can induce Ferroptosis in liver damage with oral activity. Gingerenone A has anti-inflammatory, anti-diabetic, anti-tumor, and pro-aging effects in mice ^[4].

HY-N0070R

Solasonine (Standard)	Ferroptosis Glutathione Peroxidase Reactive Oxygen Species	Cancer
Solasonine (Standard) is the analytical standard of Solasonine. This product is intended for research and analytical applications. Solasonine is a ferroptosis inducer which can be isolated from Solanum melongena that has anti-infection, anti-cancer, and neurogenesis promoting properties. Solasonine promotes ferroptosis of HCC cells via destruction of the glutathione redox system induced by inhibiting GPX4, and can be used for cancer research .

HY-138153

JKE-1674 3 Publications Verification	Glutathione Peroxidase Ferroptosis	Cancer
JKE-1674 is an orally active glutathione peroxidase 4 (GPX4) inhibitor and an active metabolite of *GPX4* inhibitor ML-210. JKE-1674, an analog of ML-210 in which the nitroisoxazole ring is replaced with an α-nitroketoxime. JKE-1674 can convert into a nitrile oxide JKE-1777. JKE-1674 kills LOX-IMVI cells in a manner that is equipotent to ML-210 and is completely rescued by ferroptosis inhibitors .

HY-153748

ML162-yne	Glutathione Peroxidase	Cancer
ML162-yne is a potent GPX4-inhibitor affinity probe . ML162-yne is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-100218C

(1R,3R)-RSL3	Drug Isomer Ferroptosis	Cancer
(1R,3R)-RSL3 is an isomer of RSL3 (HY-100218A). RSL3 ((1S,3R)-RSL3) is an inhibitor of glutathione peroxidase 4 (GPX4) (ferroptosis activator), reduces the expression of GPX4 protein, and induces ferroptotic death of head and neck cancer cell. RSL3 increases the expression of p62 and Nrf2 and inactivates Keap1 in HN3-rslR cells .

HY-161933

1-Adamantane-amide-C7-NH2	PROTAC Linkers	Cancer
1-Adamantane-amide-C7-NH2 is the linker, which can be used for syntheisis of PROTAC GPX4 degrader-3 (HY-161930) .

HY-167888

NPD4928	Ferroptosis Glutathione Peroxidase	Cancer
NPD4928, a *GPX4* inhibitor, enhances RSL3 (HY-100218A)-dependent ferroptosis. NPD4928 binds to ferroptosis suppressor protein 1 (FSP1) and inhibits its enzymatic activity .

HY-151212

BCP-T.A	Ferroptosis Glutathione Peroxidase	Cancer
BCP-T.A, a tunable heterocyclic electrophile, is a potent ferroptosis inducer by binding to *GPX4* . BCP-T.A is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-151429

Antitumor agent-77	Apoptosis Ferroptosis Bcl-2 Family COX	Cancer
Antitumor agent-77 is an antitumor agent, inhibits cancer cells growth and migration. Antitumor agent-77 triggers ferroptosis by inhibiting GPx-4 and elevating COX2. Antitumor agent-77 also activates intrinsic apoptotic pathway (Bax-Bcl-2-caspase-3) and hinders Epithelial-mesenchymal transition (EMT) process of cancer cells .

HY-151428

Antitumor agent-78	Ferroptosis Apoptosis Bcl-2 Family COX	Cancer
Antitumor agent-78 is an antitumor agent, inhibits cancer cells growth and migration. Antitumor agent-78 triggers ferroptosis by inhibiting GPx-4 and elevating COX2. Antitumor agent-78 also activates intrinsic apoptotic pathway (Bax-Bcl-2-caspase-3) and hinders Epithelial-mesenchymal transition (EMT) process of cancer cells .

HY-155075

NC-R17	PROTACs Glutathione Peroxidase Ferroptosis	Cancer
NC-R17 is a PROTAC-class, non-covalent *GPX4* degrader based on RSL3, involved in ferroptosis. NC-R17 has antitumor activity and is used for non-covalent GPX4 PROTAC design . NC-R17 consists of a target protein ligand (red part) Demethyl-RSL3 (HY-135832); an E3 ubiquitin ligase ligand (blue part) Lenalidomide (HY-A0003) and a PROTAC linker (black part) (HY-169376). E3 ubiquitin ligase and linker can form Lenalidomide-C13-piperazine-Boc (HY-169377) .

HY-136057

iFSP1 15+ Cited Publications	Ferroptosis	Cancer
iFSP1 is a potent, selective and glutathione-independent inhibitor of ferroptosis suppressor protein 1 (FSP1) (AIFM2) with an EC₅₀ of 103 nM. iFSP1 selectively induces ferroptosis in GPX4-knockout cells which overexpressed FSP1. iFSP1 is able to sensitize a variety of human cancer cell lines to the ferroptosis inducer, such as (1S,3R)-RSL3 (HY-100218A) .

HY-B0774

Seratrodast 4 Publications Verification AA 2414	Ferroptosis JNK MDM-2/p53 Prostaglandin Receptor Reactive Oxygen Species	Neurological Disease Inflammation/Immunology Endocrinology Cancer
Seratrodast (AA 2414), an orally active antiasthmatic agent, is a thromboxane A2 receptor (TP) antagonist and ferroptosis inhibitor. Seratrodast reduces lipid ROS production, modulates the systemic xc-/GSH/GPX4 axis, and inhibits JNK phosphorylation and p53 expression. Seratrodast exhibits anti-asthmatic and anti-epileptic activity .

HY-157788

ZX703	PROTACs Reactive Oxygen Species Ferroptosis Glutathione Peroxidase	Cancer
ZX703 (compound 5I) is a PROTAC that significantly degrades *GPX4* in a dose- and time-dependent manner through the ubiquitin-proteasome and autophagy-lysosome pathways (DC₅₀=0.315 µM). ZX703 induces ferroptosis by inducing Reactive Oxygen Species (ROS) accumulation in cells. ZX703 can be used for cancer research .

Cat. No.	Product Name	Type

HY-Y0669

Pipecolic acid

2 Publications Verification

Cell Assay Reagents

Pipecolic acid is a metabolite of lysine and an immunomodulator, which can induce systemic acquired resistance (SAR) in plants. Pipecolic acid inhibits ferroptosis in diabetic retinopathy through the YAP-GPX4 signaling pathway. Pipecolic acid can induce apoptosis in neuronal cells. In addition, Pipecolic acid can be used as a diagnostic marker for pyridoxin-dependent epilepsy ^[4] .

HY-Y0669R

Pipecolic acid (Standard)

Cell Assay Reagents

Pipecolic acid (Standard) is the analytical standard of Pipecolic acid. This product is intended for research and analytical applications. Pipecolic acid is a metabolite of lysine and an immunomodulator, which can induce systemic acquired resistance (SAR) in plants. Pipecolic acid inhibits ferroptosis in diabetic retinopathy through the YAP-GPX4 signaling pathway. Pipecolic acid can induce apoptosis in neuronal cells. In addition, Pipecolic acid can be used as a diagnostic marker for pyridoxin-dependent epilepsy .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0070

Solasonine 2 Publications Verification	Alkaloids Piperidine Alkaloids Structural Classification Classification of Application Fields Source classification Solanum nigrum Linn. Solanaceae Plants Disease Research Fields Cancer	Ferroptosis Glutathione Peroxidase Reactive Oxygen Species
Solasonine is a ferroptosis inducer which can be isolated from Solanum melongena that has anti-infection, anti-cancer, and neurogenesis promoting properties. Solasonine promotes ferroptosis of HCC cells via destruction of the glutathione redox system induced by inhibiting GPX4, and can be used for cancer research .

HY-120912

Gingerenone A	Zingiber officinale Roscoe Structural Classification Source classification Phenols Polyphenols Plants Zingiberaceae	Keap1-Nrf2 Glutathione Peroxidase Ferroptosis
Gingerenone A is an Nrf2-Gpx4 activator that can induce Ferroptosis in liver damage with oral activity. Gingerenone A has anti-inflammatory, anti-diabetic, anti-tumor, and pro-aging effects in mice ^[4].

HY-155852

Lepadin H	Structural Classification Alkaloids Animals Source classification Marine natural products Other marine organisms Quinoline Alkaloids	Ferroptosis
Lepadin H is a marine alkaloid and ferroptosis inducer. Lepadin H exhibits significant cytotoxicity, promotes p53 expression, increases ROS production and lipid peroxidation, decreases SLC7A11 and GPX4 levels, and upregulates ACSL4 expression. Lepadin H induces ferroptosis through the p53-SLC7A11-GPX4 pathway .

HY-155851

Lepadin E	Structural Classification Alkaloids Animals Source classification Marine natural products Other marine organisms Quinoline Alkaloids	Ferroptosis MDM-2/p53 Glutathione Peroxidase
Lepadin E is a significantly cytotoxic ferroptosis inducer that induces iron death through the classical p53-SLC7A11-GPX4 pathway. Lepadin E promoted p53 expression, decreases SLC7A11 and GPX4 levels, and leads to increased ROS and lipid peroxide production, and upregulated ACSL4 expression, thus causes cell death. Lepadin E has significant antitumor effect .

HY-N0070R

Solasonine (Standard)	Alkaloids Piperidine Alkaloids Structural Classification Source classification Solanum nigrum Linn. Solanaceae Plants	Ferroptosis Glutathione Peroxidase Reactive Oxygen Species
Solasonine (Standard) is the analytical standard of Solasonine. This product is intended for research and analytical applications. Solasonine is a ferroptosis inducer which can be isolated from Solanum melongena that has anti-infection, anti-cancer, and neurogenesis promoting properties. Solasonine promotes ferroptosis of HCC cells via destruction of the glutathione redox system induced by inhibiting GPX4, and can be used for cancer research .

Species:	Human (2)
Tag:	His (1) Flag (1)
Source:	HEK293 (1) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P703942

	GPX4 Protein, Human (HEK293, Flag) Phospholipid hydroperoxide glutathione peroxidase; PHGPX; Glutathione peroxidase 4; GPX-4; GSHPx-4	Human	HEK293

HY-P702646

	GPX4 Protein, Human (U73S, His) PHGPX; Glutathione peroxidase 4; GPX-4; GSHPx-4	Human	E. coli
	GPX4 Protein, Human (U73S, His) is the recombinant human-derived GPX4, expressed by E. coli , with N-6*His labeled tag. ,

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HY-Y0669S

Pipecolic acid-d9

Pipecolic acid-d₉ is the deuterium labeled Pipecolic acid. Pipecolic acid is a metabolite of lysine and an immunomodulator, which can induce systemic acquired resistance (SAR) in plants. Pipecolic acid inhibits ferroptosis in diabetic retinopathy through the YAP-GPX4 signaling pathway. Pipecolic acid can induce apoptosis in neuronal cells. In addition, Pipecolic acid can be used as a diagnostic marker for pyridoxin-dependent epilepsy .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P80450

	GPX4 Antibody 3 Publications Verification	WB, IHC-P, ICC/IF	Human, Mouse, Rat
	GPX4 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 22 kDa, targeting to GPX4. It can be used for WB,IHC-P,ICC assays with tag free, in the background of Human, Mouse, Rat.

HY-P80692

	Glutathione Peroxidase 4 Antibody Phospholipid hydroperoxide glutathione peroxidase; mitochondrial; PHGPX; EC 1.11.1.12; Glutathione peroxidase 4; GPX-4; GSHPx-4	WB, IHC-F, IHC-P, ICC/IF	Human, Mouse, Rat
	Glutathione Peroxidase 4 Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 22 kDa, targeting to Glutathione Peroxidase 4. It can be used for WB,IHC-F,IHC-P,ICC/IF assays with tag free, in the background of Human, Mouse, Rat.