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Results for "

GTPases

" in MedChemExpress (MCE) Product Catalog:

65

Inhibitors & Agonists

3

Peptides

5

Natural
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2

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-117149
    MLS000532223

    		Ras Cancer
    MLS000532223 is a high affinity, selective inhibitor of Rho family GTPases, with EC50 values ranging from 16 μM to 120 μM. MLS000532223 prevents GTP binding to several GTPases .
    MLS000532223
  • HY-113849
    MLS-573151
    1 Publications Verification

    MLS000573151

    		 Ras Inflammation/Immunology
    MLS-573151 (MLS000573151) is a selective GTPase Cdc42 inhibitor with an EC50 of 2 μM. MLS-573151 is inactive against other GTPases family members, such as Rab2, Rab7, H-Ras, Rac1, Rac 2 and RhoA wild-type. MLS-573151 acts by blocking the binding of GTP to Cdc42 .
    MLS-573151
  • HY-W174279
    Tyrphostin 8

    		EGFR Ras Phosphatase Metabolic Disease
    Tyrphostin 8 is a tyrosine kinase, with an IC50 of 560 μM for EGFR kinase. Tyrphostin 8 is also a GTPase inhibitor. Tyrphostin 8 can inhibit the protein serine/threonine phosphatase calcineurin (IC50=21 μM) .
    Tyrphostin 8
  • HY-13452
    CID-1067700
    5+ Cited Publications

    ML282

    		 Ras Inflammation/Immunology
    CID-1067700 (ML282) is a pan GTPase inhibitor, and competitively inhibits Ras-related in brain 7 (Rab7) with a Ki of 13 nM.
    CID-1067700
  • HY-152218
    Clathrin-IN-4

    		Dynamin Neurological Disease
    Clathrin-IN-4 (compound 8b), a Wiskostatin (HY-12534) analogue, is a potent inhibitor of clathrin mediated endocytosis with an IC50 of 2.1 μM. Clathrin-IN-4 is a dynamin I GTPase activity inhibitor with an IC50 of 9.1 μM .
    Clathrin-IN-4
  • HY-136197
    StRIP16

    		Ras Cancer
    StRIP16, bioavailable StRIP3 analogue, is a double-stapled peptide which can bind to Rab8a GTPase, with a Kd of 12.7 μM .
    StRIP16
  • HY-W549903
    p67phox-IN-1

    		NADPH Oxidase Ras Cancer
    p67phox-IN-1 (Formula IIIa Compound) is an inhibitor targeting the interaction between Rac GTPase and p67 phox protein .
    p67phox-IN-1
  • HY-146330
    FtsZ-IN-2

    		Bacterial Infection
    FtsZ-IN-2 (Compound 19) is an inhibitor of the bacterial cell division protein FtsZ with GTPase inhibitory activity. FtsZ-IN-2 exhibits anti-staphylococcal activity with MIC values of 2 µg/ml for MSSA and MRSA .
    FtsZ-IN-2
  • HY-134274
    8-Br-GTP

    8-Bromoguanosine-5'-triphosphate

    		 Bacterial Infection
    8-Br-GTP, a GTP analog, is a competitive FtsZ polymerization and GTPase activity (Ki of 31.8 μM) inhibitor. 8-Br-GTP can be used for nucleic acid modification .
    8-Br-GTP
  • HY-152217
    Clathrin-IN-2

    		Dynamin Neurological Disease Metabolic Disease Cancer
    Clathrin-IN-2 is potent inhibitor of clathrin mediated endocytosis (CME) with an IC50 value of 2.3 μM. Clathrin-IN-2 also has inhibitiory for dyn I GTPase with an IC50 value of 7.7 μM .
    Clathrin-IN-2
  • HY-125987
    RBC6

    		Others Cancer
    RBC6 is an inhibitor of GTPases RalA. RBC6 inhibits binding of Ral to its effector RALBP1. RBC6 also inhibits Ral-mediated cell spreading of murine embryonic fibroblasts, as well as anchorage-independent growth of human cancer celllines .
    RBC6
  • HY-125355
    SEC

    		Apoptosis Cancer
    SEC induces activation of ANXA7 GTPase via the AMPK/mTORC1/STAT3 signaling pathway. SEC selectively promotes apoptosis in cancer cells, expressing a high level of ITGB4 by inducing ITGB4 nuclear translocation .
    SEC
  • HY-145080
    Dynole 2−24

    		Dynamin Neurological Disease
    Dynole 2−24 is an indole-based dynamin GTPase inhibitor (IC50=0.56 μM for dynamin I). Dynole 2−24 is nontoxic and shows increased potency against dynamin I and II in vitro and in cells (IC₅₀(CME)=1.9 μM). Dynole 2−24 also shows 4.4-fold selectivity for dynamin I. Dynole 2−24 is active in-cell inhibitor of clathrin-mediated endocytosis . CME: Clathrin mediated endocytosis
    Dynole 2−24
  • HY-149223
    FtsZ-IN-5

    		Bacterial Infection
    FtsZ-IN-5 is a potent FtsZ inhibitor, to promote FtsZ polymerization and inhibit GTPase activity of FtsZ. Thus, FtsZ-IN-5 inhibits bacterial division to lead to death of bacterial cells. FtsZ-IN-5 shows bactericidal activity with no significant tendency to trigger bacterial resistance as well as rapid bactericidal properties. And FtsZ-IN-5 shows low hemolytic activity and cytotoxicity to mammalian cells .
    FtsZ-IN-5
  • HY-149224
    FtsZ-IN-6

    		Bacterial Infection
    FtsZ-IN-6 is a potent FtsZ inhibitor, to promote FtsZ polymerization and inhibit GTPase activity of FtsZ. Thus, FtsZ-IN-6 inhibits bacterial division to lead to death of bacterial cells. FtsZ-IN-6 shows bactericidal activity with no significant tendency to trigger bacterial resistance as well as rapid bactericidal properties. And FtsZ-IN-6 shows low hemolytic activity and cytotoxicity to mammalian cells .
    FtsZ-IN-6
  • HY-149225
    FtsZ-IN-7

    		Bacterial Infection
    FtsZ-IN-7 is a potent FtsZ inhibitor, to promote FtsZ polymerization and inhibit GTPase activity of FtsZ. Thus, FtsZ-IN-7 inhibits bacterial division to lead to death of bacterial cells. FtsZ-IN-7 shows bactericidal activity with no significant tendency to trigger bacterial resistance as well as rapid bactericidal properties. And FtsZ-IN-7 shows low hemolytic activity and cytotoxicity to mammalian cells .
    FtsZ-IN-7
  • HY-149226
    FtsZ-IN-8

    		Bacterial Infection
    FtsZ-IN-8 is a potent FtsZ inhibitor, to promote FtsZ polymerization and inhibit GTPase activity of FtsZ. Thus, FtsZ-IN-8 inhibits bacterial division to lead to death of bacterial cells. FtsZ-IN-8 shows bactericidal activity with no significant tendency to trigger bacterial resistance as well as rapid bactericidal properties. And FtsZ-IN-8 shows low hemolytic activity and cytotoxicity to mammalian cells .
    FtsZ-IN-8
  • HY-152095
    PPI-GIT1/β-Pix interaction-IN-1

    		Ras Cancer
    PPI-GIT1/β-Pix interaction-IN-1 is a potent and orally active GIT1/β-Pix protein-protein interaction (PPI) inhibitor with a KD value of 7.7 µM. PPI-GIT1/β-Pix interaction-IN-1 disrupts the GIT/PIX interaction can impact the activation of the downstream Rho GTPase Rac1 and Cdc42. PPI-GIT1/β-Pix interaction-IN-1 inhibits metastasis of gastric cancer .
    PPI-GIT1/β-Pix interaction-IN-1
  • HY-129189
    RAS GTPase inhibitor 1

    		Ras Cancer
    RAS GTPase inhibitor 1 (example 51) is a RAS GTPase inhibitor with anti-tumor activity, extracted from patent WO2018212774A1. RAS GTPase inhibitor 1 (example 51) exhibits an EC50 less than 1 μM for at least one nucleotide exchange and an IC50 less than 1 μM in H727 cells .
    RAS GTPase inhibitor 1
  • HY-15723
    NSC 23766
    Maximum Cited Publications
    35 Publications Verification

    		 Ras Cancer
    NSC 23766 is a cell-permeable, reversible and specific inhibitor of Rac GTPase, used for cancer treatment.
    NSC 23766
  • HY-129422
    Diallyl G

    		Opioid Receptor Neurological Disease
    Diallyl G is a delta-opioid receptor antagonist. Diallyl G shows inhibitory effect on GTPase .
    Diallyl G
  • HY-115739
    RTIL 13

    		Ras Neurological Disease Cancer
    RTIL 13 is a potent inhibitor of dynamin GTPase, with an IC50 of 2.3 μM for dynamin I GTPase. RTIL 13 also targets pleckstrin homology lipid binding domain. RTIL 13 can inhibit receptor-mediated and synaptic vesicle endocytosis, with IC50s of 9.3 μM and 7.1 μM, respectively .
    RTIL 13
  • HY-12874
    CASIN
    5+ Cited Publications

    		 Ras Apoptosis Cancer
    CASIN is a selective GTPase Cdc42 inhibitor with an IC50 of 2 uM. CASIN can be used for the research of cancer .
    CASIN
  • HY-W013706
    Inosine-5'-triphosphate trisodium salt

    		Endogenous Metabolite Metabolic Disease
    Inosine-5'-triphosphate trisodium salt is a nucleoside triphosphate and functions as an substrate for ATPases and GTPases .
    Inosine-5'-triphosphate trisodium salt
  • HY-113066A
    Guanosine 5'-diphosphate disodium salt
    2 Publications Verification

    GDP disodium salt

    		 Endogenous Metabolite Potassium Channel Neurological Disease Inflammation/Immunology
    Guanosine 5'-diphosphate (GDP) disodium salt, a purine nucleoside diphosphate, is interconverted to guanosine by the action of exonucleotidase and phosphorylation of nucleoside to guanine. Guanosine 5'-diphosphate disodium salt activates adenosine 5'-triphosphate-sensitive K + channel and is used to study the kinetics and characteristics of GTPases such as those associated with G-protein coupled receptors (GPCR). Guanosine 5'-diphosphate disodium salt is a potential iron mobilizer, which prevents the Hepcidin (HY-P70400)-ferroportin interaction and modulates the interleukin-6 (IL-6)/stat-3 pathway. Elevated levels of guanosine 5’-diphosphate are associated with the pathogenesis of neurological diseases. Guanosine 5'-diphosphate disodium salt is promising for the research of inflammation, such as anemia of inflammation (AI) .
    Guanosine 5'-diphosphate disodium salt
  • HY-107545
    Dynole 34-2
    1 Publications Verification

    		 Dynamin Cancer
    Dynole 34-2 is a dynamin GTPase inhibitor (IC50s=6.9 and 14.2 µM for dynamin1 and dynamin2 GTPase activity, respectively) with antimitotic effect. Dynole 34-2 induces apoptosis, as revealed by cell blebbing, DNA fragmentation, and PARP cleavage . Dynole 34-2 also potently inhibits receptor mediated endocytosis (RME) .
    Dynole 34-2
  • HY-158359
    5′-XDP sodium

    Xanthosine 5′-diphosphate sodium

    		 Others Others
    5’-XDP sodium (Xanthosine 5' -diphosphate sodium) is an ADP analog involved in the synthesis of ribosomes .
    5′-XDP sodium
  • HY-154959
    AZD4747

    		Ras Cancer
    AZD4747 is a selective, blood-brain barrier-permeable mutant GTPase KRAS G12C inhibitor. AZD4747 has the potential to study cancer .
    AZD4747
  • HY-12873
    RBC8

    		Ras Cancer
    RBC8 is a novel small molecule inhibitor of Ral GTPase; has IC50 of 3.5 μM in H2122 cell and 3.4 μM in H358 cell.
    RBC8
  • HY-146223
    AZD4625

    		Ras Cancer
    AZD4625 (Compound 21) is a highly potent, selective, covalent and allosteric inhibitor of the mutant GTPase KRAS G12C. AZD4625 has high oral bioavailability .
    AZD4625
  • HY-118208
    ML-097
    1 Publications Verification

    CID-2160985

    		 Ras Cancer
    ML-097 (CID-2160985) is a pan Ras-related GTPases activator that can activate Rac1, cell division cycle 42, Ras, and Rab7 .
    ML-097
  • HY-12755
    ML141
    15+ Cited Publications

    CID-2950007

    		 Ras Apoptosis Cancer
    ML141 (CID-2950007) is a potent, allosteric, selective and reversible non-competitive inhibitor of Cdc42 GTPase. ML141 inhibits Cdc42 wild type and Cdc42 Q61L mutant with EC50s of 2.1 and 2.6 μM, respectively. ML141 shows low micromolar potency and selectivity against other members of the Rho family of GTPases (Rac1, Rab2, Rab7). ML141 do not show cytotoxicity in multiple cell lines .
    ML141
  • HY-124306
    ML-099
    2 Publications Verification

    CID-888706

    		 Ras Cancer
    ML-099 (CID-888706) is a pan Ras-related GTPases activator that can activate Rac1, cell division cycle 42, Ras, Rab7, and Rab-2A .
    ML-099
  • HY-149464
    ARN22089

    		Ras Cancer
    ARN22089 is a oral active novel class of trisubstituted pyrimidine, blocks the interaction of CDC42 GTPases with specific downstream effectors. ARN22089 blocks tumor growth in BRAF mutant mouse melanoma model .
    ARN22089
  • HY-16563
    Narciclasine
    10+ Cited Publications

    Lycoricidinol

    		 ROCK Cancer
    Narciclasine is a plant growth modulator. Narciclasine modulates the Rho/Rho kinase/LIM kinase/cofilin signaling pathway, greatly increasing GTPase RhoA activity as well as inducing actin stress fiber formation in a RhoA-dependent manner.
    Narciclasine
  • HY-106423
    Mivobulin

    CI-980 free base; NSC 613862; (S)-(-)-NSC 613862

    		 Microtubule/Tubulin Cancer
    Mivobulin (NSC 613862) is a tubulin inhibitor, binds to tubulin in the region that overlaps the colchicine site, and inhibits tubulin polymerization. Mivobulin (NSC 613862) promotes the formation of abnormal polymers and a GTPase activity in the tubulin dimer. Anti-cancer activity .
    Mivobulin
  • HY-164290
    Rhodady C10

    		Dynamin Infection Neurological Disease
    Rhodady C10 (Compound C10) is a dynamin I GTPase inhibitor. Rhodady C10 blocks receptor-mediated endocytosis (IC50: 7 μM). Dynamin is involved in clathrin-independent endocytosis, phagocytosis, and caveolae internalization .
    Rhodady C10
  • HY-123345
    CRT 0105446

    		LIM Kinase (LIMK) Cancer
    CRT 0105446 (compound 22d) is a LIMK1 inhibitor, with an IC50 of 8 nM .
    CRT 0105446
  • HY-16659
    EHT 1864
    10+ Cited Publications

    		 Ras Neurological Disease Cancer
    EHT 1864 is an inhibitor of Rac family small GTPases. EHT 1864 directly binds and impairs the ability of this small GTPase to engage critical downstream effectors required for growth transformation. The Kd values are 40, 50, 60, and 230 nM for Rac1, Rac1b, Rac2 and Rac3, respectively. EHT 1864 also potently inhibits other Rac-dependent transformation processes, Tiam1- and Ras-mediated growth transformation. EHT 1864 prevents Aβ 40 and Aβ 42 production in vivo. EHT 1864 dependently suppresses the release of migrasomes from podocytes induced by LPS, PAN, or HG .
    EHT 1864
  • HY-152216
    Dynamin IN-2

    		Dynamin Neurological Disease
    Dynamin IN-2 (compound 43), a Wiskostatin (HY-12534) analogue, is a potent dynamin inhibitor, with an IC50 of 1.0 μM for dynamin I GTPase. Dynamin IN-2 also blocks clathrin mediated endocytosis (CME), with an IC50 of 9.5 μM .
    Dynamin IN-2
  • HY-155656
    Anti-inflammatory agent 49

    		Others Inflammation/Immunology
    nti-inflammatory agent 49 (compound SC9) is a quite potent and selective inhibitor of Drp1-Fis1 interaction and can reduce FIS1-mediated mitochondrial dysfunction. The IC50 of SC9 inhibiting GTPase in vitro is 270 nM .
    Anti-inflammatory agent 49
  • HY-12762
    QS11
    1 Publications Verification

    		 Others Cancer
    QS11 is an inhibitor of ARFGAP1 (ADP-ribosylation factor GTPase-activating protein 1), with an EC50 of 1.5 μM. QS11 modulates Wnt/β-catenin signaling through an effect on protein trafficking. QS11 inhibits migration of ARFGAP overexpressing breast cancer cells .
    QS11
  • HY-154959A
    (9R,12aR)-AZD4747

    		Others Cancer
    (9R,12aR)-AZD4747 is a diastereomer of AZD4747 (HY-154959). AZD4747 is a selective mutant GTPase KRAS G12C inhibitor with blood-brain barrier permeability. AZD4747 has the potential to study cancer .
    (9R,12aR)-AZD4747
  • HY-111549
    Bragsin1

    		Others Cancer
    Bragsin1 is a potent, selective and noncompetitive inhibitor of the ArfGEF BRAG2, inhibits Arf GTPase activation, with an IC50 of 3 μM. Bragsin1 binds to PH domain of BRAG2, and is a noncompetitive interfacial inhibitor. Bragsin1 has no effect on the Sec7 domain of human ArfGEFs. Anti-cancer activity .
    Bragsin1
  • HY-16563R
    Narciclasine (Standard)

    		ROCK Cancer
    Narciclasine (Standard) is the analytical standard of Narciclasine. This product is intended for research and analytical applications. Narciclasine is a plant growth modulator. Narciclasine modulates the Rho/Rho kinase/LIM kinase/cofilin signaling pathway, greatly increasing GTPase RhoA activity as well as inducing actin stress fiber formation in a RhoA-dependent manner.
    Narciclasine (Standard)
  • HY-111550
    Bragsin2
    1 Publications Verification

    		 Others Cancer
    Bragsin2 is a potent, selective and noncompetitive nucleotide exchange factor BRAG2 inhibitor, with an IC50 of 3 μM. Bragsin2 binds at the interface between the PH domain of BRAG2 and the lipid bilayer, leads BRAG2 unable to activate lipidated Arf GTPase. Bragsin2 affects breast cancer stem cells .
    Bragsin2
  • HY-131649
    Compound C108

    		Others Cancer
    Compound C108 is a G3BP2 inhibitor. Compound C108 also targeted stress granule-associated proteins and Gtpase-activating protein (SH3 domain) binding protein 2. Compound C108 potently inhibits esophageal squamous cell carcinoma (ESCC) cell metastasis .
    Compound C108
  • HY-13863
    Hydroxy-Dynasore
    3 Publications Verification

    Dyngo-4a

    		 Dynamin Neurological Disease
    Hydroxy Dynasore (Dyngo-4a), a structural mimetic analog of Dynasore (HY-15304), is an improved, less cytotoxic and versatile dynamin inhibitor with IC50 values ​​of 0.38 μM and 2.3 μM for brain recombinant dynamin I and recombinant mouse dynamin II, respectively. Hydroxy Dynasore inhibits dynamin-dependent transferrin endocytosis with an IC50 of 5.7 μM.
    Hydroxy-Dynasore
  • HY-126992
    Sarasinoside A1

    		Others Cancer
    Sarasinoside A1 is a triterpenoid saponin that inhibits breast cancer cell invasion and induces re-epithelialization. Sarasinoside A1 activates Rap GTPase and promotes the relocalization of β-catenin and ZO-1 at cell-cell contact points. Sarasinoside A1 also increases intercellular space stability and the formation of cell-cell junctions.
    Sarasinoside A1
  • HY-165040
    1-Palmitoyl-2-stearoyl-rac-glycerol

    DG(16:0/18:0/0:0); 1-Palmitin-2-Stearin

    		 Others Others
    1-Palmitoyl-2-stearoyl-rac-glycerol (DG(16:0/18:0/0:0)) is a compound mentioned in the study of the activation of ADP-ribosylation factor 1 GTPase activating protein by phosphatidylcholine-derived diacylglycerol, and related studies have shown that it may be involved in certain feedback mechanisms within cells.
    1-Palmitoyl-2-stearoyl-rac-glycerol

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