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Results for "

HMG-CoA Reductase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Acetyl-CoA Carboxylase (1) HMG-CoA Reductase (HMGCR) (91) Antibiotic (3) Apoptosis (15) Autophagy (54) Bacterial (8) Biochemical Assay Reagents (3) Cytochrome P450 (2) Dengue virus (1) Drug Metabolite (25) Endogenous Metabolite (12) Farnesyl Transferase (2) Fatty Acid Synthase (FASN) (1) Ferroptosis (19) Flavivirus (1) Fungal (1) Glucosidase (1) HCV (2) HIV Protease (1) Isotope-Labeled Compounds (14) Mitophagy (12) p38 MAPK (1) Potassium Channel (8) Reactive Oxygen Species (6)
By Research Areas:	Cancer (49) Cardiovascular Disease (79) Endocrinology (1) Infection (7) Inflammation/Immunology (24) Metabolic Disease (77) Neurological Disease (8)

By Targets:

Acetyl-CoA Carboxylase (1)

HMG-CoA Reductase (HMGCR) (91)

Antibiotic (3)

Apoptosis (15)

Autophagy (54)

Bacterial (8)

Biochemical Assay Reagents (3)

Cytochrome P450 (2)

Dengue virus (1)

Drug Metabolite (25)

Endogenous Metabolite (12)

Farnesyl Transferase (2)

Fatty Acid Synthase (FASN) (1)

Ferroptosis (19)

Flavivirus (1)

Fungal (1)

Glucosidase (1)

HCV (2)

HIV Protease (1)

Isotope-Labeled Compounds (14)

Mitophagy (12)

p38 MAPK (1)

Potassium Channel (8)

Reactive Oxygen Species (6)

By Research Areas:

Cancer (49)

Cardiovascular Disease (79)

Endocrinology (1)

Infection (7)

Inflammation/Immunology (24)

Metabolic Disease (77)

Neurological Disease (8)

144

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Targets Recommended: HMG-CoA Reductase (HMGCR) Glutathione Reductase Aldose Reductase 5 alpha Reductase Dihydrofolate reductase (DHFR) Stearoyl-CoA Desaturase (SCD) Acetyl-CoA Carboxylase TrxR GSNOR Acyltransferase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-114294A

DL-3-Hydroxy-3-methylglutaryl coenzyme A disodium hydrate HMG-CoA disodium hydrate	Biochemical Assay Reagents	Metabolic Disease
DL-3-Hydroxy-3-methylglutaryl coenzyme A disodium hydrate is a disodium salt compound of HMG-CoA, is a intermediate of terpenes and ketone bodies. DL-3-Hydroxy-3-methylglutaryl coenzyme A disodium also involves in ester metabolism in vivo, as a precursor for cholesterol synthesis, and regulates cholesterol synthesis by coupling LDL receptor .

HY-123672

Lovastatin hydroxy acid sodium Mevinolinic acid sodium	HMG-CoA Reductase (HMGCR)	Metabolic Disease
Lovastatin hydroxy acid sodium (Mevinolinic acid sodium) is a highly potent inhibitor of HMG-CoA reductase with a K_i of 0.6 nM .

HY-14664AS

Fluvastatin-d6 sodium XU 62-320-d₆	HMG-CoA Reductase (HMGCR) Autophagy	Cardiovascular Disease Cancer
Fluvastatin-d₆ (sodium) is deuterium labeled Fluvastatin sodium. Fluvastatin sodium (XU 62320) is a first fully synthetic, competitive HMG-CoA reductase inhibitor with an IC50 of 8 nM.

HY-155668

HMG-CoA Reductase-IN-1	HMG-CoA Reductase (HMGCR)	Metabolic Disease
HMG-CoA Reductase-IN-1 is a HMG-CoA reductase inhibitor. HMG-CoA Reductase-IN-1has high HMGR inhibitory activity and OATP1B1 affinity with pIC₅₀ and pKm values of 8.54 and 1.98, respectively. HMG-CoA Reductase-IN-1 can be used for the research of hypercholesterolemia .

HY-W712674

*HMG-CoA* 3-Hydroxy-3-methylglutaryl-CoA	Others	Metabolic Disease
HMG-CoA is a product generated by the hydration reaction of (E)-3-methylglutaconyl-CoA (MG-CoA) catalyzed by methylglutaconyl-CoA hydratase (MGCH) .

HY-16152

Crilvastatin PMD 387	HMG-CoA Reductase (HMGCR)	Metabolic Disease
Crilvastatin (PMD 387) is a potent inhibitor of HMG-CoA reductase .

HY-135402

2'-Ethyl Simvastatin	HMG-CoA Reductase (HMGCR)	Cardiovascular Disease Cancer
2'-Ethyl Simvastatin (compound 6) is a Mevinolin analog, with HMG-CoA reductase inhibition .

HY-16166

Dalvastatin RG-12561	HMG-CoA Reductase (HMGCR)	Inflammation/Immunology
Dalvastatin (RG-12561) inhibitor of HMG-CoA reductase and cholesterol-lowering synthesis .

HY-122439

Lovastatin acid Mevinolinic acid; MSD803	HMG-CoA Reductase (HMGCR) Drug Metabolite	Cardiovascular Disease Cancer
Lovastatin acid (Mevinolinic acid), an active metabolite of Lovastatin, is a potent competitive HMG-CoA reductase inhibitor with a K_i of 0.6 nM .

HY-N10076

Ganomycin I	HMG-CoA Reductase (HMGCR) Glucosidase HIV Protease	Infection Metabolic Disease
Ganomycin I is a dual inhibitor of α-Glucosidase and HMG-CoA reductase. Ganomycin I can also inhibits HIV protease. Ganomycin I exhibits anti-diabetic and anti-osteoclastogenesis effects .

HY-136185

Atorvastatin Epoxy Tetrahydrofuran Impurity	Drug Metabolite	Others
Atorvastatin Epoxy Tetrahydrofuran Impurity is an impurity isolated oxidative degradation products of Atorvastatin (HY-B0589) . Atorvastatin is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids.

HY-14664A

Fluvastatin sodium 10+ Cited Publications XU 62-320	HMG-CoA Reductase (HMGCR) Autophagy Ferroptosis	Cardiovascular Disease Cancer
Fluvastatin sodium (XU 62320) is a first fully synthetic, competitive HMG-CoA reductase inhibitor with an IC₅₀ of 8 nM. Fluvastatin sodium protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway .

HY-14664

Fluvastatin 10+ Cited Publications XU 62-320 free acid	HMG-CoA Reductase (HMGCR) Autophagy	Cardiovascular Disease Cancer
Fluvastatin (XU 62-320 free acid) is a first fully synthetic, competitive HMG-CoA reductase inhibitor with an IC₅₀ of 8 nM. Fluvastatin protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway .

HY-139134

S-2E	HMG-CoA Reductase (HMGCR) Acetyl-CoA Carboxylase	Cardiovascular Disease
S-2E is an orally active and noncompetitive HMG-CoA reductase and acetyl-CoA carboxylase inhibitor. S-2E has an anti-hyperlipidemic action. S-2E has the potential for familial hypercholesterolemia and mixed hyperlipidemia research .

HY-14664D

Fluvastatin sodium monohydrate XU 62-320 monohydrate	HMG-CoA Reductase (HMGCR) Apoptosis	Cardiovascular Disease Cancer
Fluvastatin (XU 62-320) sodium monohydrate is a first fully synthetic, competitive *HMG-CoA* reductaseinhibitor with an IC₅₀ of 8 nM. Fluvastatin (sodium monohydrate) protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway .

HY-117581

L-669,262 6-Oxo Simvastatin; Iso-simvastatin-6-one	HMG-CoA Reductase (HMGCR)	Metabolic Disease
L-669,262, a potent inhibitor of *3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, with an IC₅₀* of 0.10 ng/mL for rat liver HMG-CoA .

HY-14664AR

Fluvastatin sodium (Standard)	HMG-CoA Reductase (HMGCR) Autophagy Ferroptosis	Cardiovascular Disease Cancer
Fluvastatin (sodium) (Standard) is the analytical standard of Fluvastatin (sodium). This product is intended for research and analytical applications. Fluvastatin sodium (XU 62320) is a first fully synthetic, competitive HMG-CoA reductase inhibitor with an IC₅₀ of 8 nM. Fluvastatin sodium protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway .

HY-113342

7-Ketocholesterol 1 Publications Verification	Endogenous Metabolite p38 MAPK	Cardiovascular Disease Metabolic Disease
7-Ketocholesterol is an oxidation product of cholesterol, widely present in atherosclerotic plaques, and has a stronger atherogenic effect than cholesterol. 7-Ketocholesterol can inhibit the rate-limiting enzymes involved in bile acid and cholesterol synthesis, such as cholesterol 7α-hydroxylase and HMG-CoA reductase. 7-Ketocholesterol exhibits pro-inflammatory effects both in vivo and in vitro and can induce cell apoptosis (apoptosis) .

HY-N0504

Lovastatin 20+ Cited Publications Mevinolin	HMG-CoA Reductase (HMGCR) Autophagy Ferroptosis	Cardiovascular Disease Cancer
Lovastatin is a cell-permeable HMG-CoA reductase inhibitor used to lower cholesterol.

HY-17502

Simvastatin Maximum Cited Publications 47 Publications Verification MK 733	HMG-CoA Reductase (HMGCR) Autophagy Mitophagy Apoptosis Ferroptosis	Cardiovascular Disease Cancer
Simvastatin (MK 733) is a competitive inhibitor of HMG-CoA reductase with a K_i of 0.2 nM.

HY-13528

Clinofibrate S-8527	HMG-CoA Reductase (HMGCR) Autophagy	Metabolic Disease
Clinofibrate (S-8527) is a hypelipidemic agent and a *HMG-CoA* reductase inhibitor.

HY-104051

Monacolin J Antibiotic MB 530A; Lovastatin diol lactone	HMG-CoA Reductase (HMGCR) Autophagy	Metabolic Disease
Monacolin J is an inhibitor of cholesterol biosynthesis, and inhibits the activity of HMG-CoA reductase.

HY-14664B

(3R,5S)-Fluvastatin (3R,5S)-XU 62-320 free acid	HMG-CoA Reductase (HMGCR) Autophagy	Cardiovascular Disease Cancer
(3R,5S)-Fluvastatin is the 3R,5S-isomer Fluvastatin. Fluvastatin (XU 62-320 free acid) is a first fully synthetic, competitive HMG-CoA reductase inhibitor with an IC₅₀ of 8 nM. Fluvastatin protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway .

HY-135384

tert-Buthyl Pitavastatin	Drug Metabolite	Cardiovascular Disease
tert-Buthyl Pitavastatin is the metabolite of Pitavastatin. Pitavastatin is a potent *HMG-CoA* reductase inhibitor .

HY-135404

Anhydrosimvastatin Dehydro simvastatin	Drug Metabolite	Cardiovascular Disease Cancer
Anhydrosimvastatin (Impurity C) is an impurity of Simvastatin. Simvastatin is a competitive inhibitor of HMG-CoA reductase .

HY-138166

Rosuvastatin lactone	Drug Metabolite	Metabolic Disease
Rosuvastatin lactone is a metabolite of Rosuvastatin (HY-17504A) (HMG-CoA inhibitor) .

HY-B0144AS

Pitavastatin D4 NK-104 d₄	HMG-CoA Reductase (HMGCR) Autophagy Mitophagy Apoptosis	Metabolic Disease Cancer
Pitavastatin-d₄ is deuterium labeled Pitavastatin. Pitavastatin is a potent HMG-CoA reductase inhibitor.

HY-117780

Rawsonol	HMG-CoA Reductase (HMGCR)	Metabolic Disease
Rawsonol is a brominated diphenylmethane derivative obtained from the green alga Avrainuika rawsoni. Rawsonol exhibits inhibitory activity against 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, with activities related to cholesterol biosynthesis inhibition or other metabolic pathways involving HMG-CoA reductase activity .

HY-135405

4-Acetylsimvastatin	Others	Cardiovascular Disease Cancer
4-Acetylsimvastatin is an acetylated simvastatin. Simvastatin is a competitive inhibitor of HMG-CoA reductase with a K_i of 0.2 nM .

HY-B0165A

Pravastatin sodium 5 Publications Verification CS-514 sodium	HMG-CoA Reductase (HMGCR) Autophagy Ferroptosis	Cardiovascular Disease Cancer
Pravastatin sodium (CS-514 sodium) is an HMG-CoA reductase inhibitor against sterol synthesis with IC₅₀ of 5.6 μM.

HY-136347

3α-Hydroxy pravastatin sodium	HMG-CoA Reductase (HMGCR) Drug Metabolite	Cardiovascular Disease
3α-Hydroxy pravastatin sodium is the major metabolite of Pravastatin. Pravastatin is a competitive HMG-CoA reductase inhibitor .

HY-116241

L-157012	HMG-CoA Reductase (HMGCR)	Metabolic Disease
L-157012 is a HMG-CoA reductase (HMGCR) inhibitor. L-157012 is also a cholesterol-lowering agent .

HY-N2923

β-Amyrin acetate	HMG-CoA Reductase (HMGCR) Fungal	Infection Cardiovascular Disease Metabolic Disease Inflammation/Immunology
β-Amyrin acetate is a triterpenoid with potent anti-inflammatory, antifungal, anti-diabetic, anti-hyperlipidemic activities. β-Amyrin acetate can inhibit *HMG-CoA* reductase activity by locating in the hydrophobic binding cleft of HMG CoA reductase .

HY-B0165

Pravastatin CS-514	Autophagy HMG-CoA Reductase (HMGCR)	Cardiovascular Disease Cancer
Pravastatin (CS-514) is a competitive HMG-CoA reductase inhibitor against sterol synthesis with IC₅₀ of 5.6 μM .

HY-N0504S1

Lovastatin-d9	Isotope-Labeled Compounds HMG-CoA Reductase (HMGCR) Autophagy Ferroptosis	Cardiovascular Disease Cancer
Lovastatin-d₉ is the deuterium labeled Lovastatin. Lovastatin is a cell-permeable HMG-CoA reductase inhibitor used to lower cholesterol.

HY-135383A

(3S,5R)-Pitavastatin calcium	Others	Metabolic Disease
(3S,5R)-Pitavastatin cacium is the enantiomer of Pitavastatin. Pitavastatin is a potent HMG-CoA reductase inhibitor .

HY-136344

Simvastatin Acyl-β-D-glucuronide	Drug Metabolite	Others
Simvastatin Acyl-β-D-glucuronide is a metabolite of Simvastatin. Simvastatin is a competitive inhibitor of HMG-CoA reductase with a K_i of 0.2 nM .

HY-N0504S2

Lovastatin-d3 Mevinolin-d₃	Isotope-Labeled Compounds HMG-CoA Reductase (HMGCR) Autophagy Ferroptosis	Cardiovascular Disease Cancer
Lovastatin-d₃ is deuterium labeled Lovastatin. Lovastatin is a cell-permeable HMG-CoA reductase inhibitor used to lower cholesterol.

HY-128828

2-Hydroxy atorvastatin calcium salt	Drug Metabolite	Metabolic Disease
2-Hydroxy atorvastatin calcium salt is a hydroxy metabolite of Atorvastatin calcium salt. Atorvastatin is a potent HMG-CoA reductase inhibitor with an IC₅₀ value of 8 nM.

HY-125643

Pitavastatin lactone	Drug Metabolite	Cardiovascular Disease
Pitavastatin lactone is a major metabolite of Pitavastatin in humans. Pitavastatin is a potent competitive inhibitor of HMG-CoA reductase little metabolized in hepatic microsomes .

HY-136345

(Rac)-3′-Hydroxy simvastatin	Drug Metabolite	Others
(Rac)-3′-Hydroxy simvastatin is a metabolite of Simvastatin. Simvastatin is a competitive inhibitor of HMG-CoA reductase with a K_i of 0.2 nM .

HY-135383

(3S,5S)-Pitavastatin calcium	Others	Metabolic Disease
(3S,5S)-Pitavastatin cacium is the 3-epimer of Pitavastatin. Pitavastatin is a potent HMG-CoA reductase inhibitor .

HY-N2924

β-Amyrin palmitate	HMG-CoA Reductase (HMGCR)	Cardiovascular Disease Endocrinology
β-Amyrin palmitate shows HMG-CoA reductase inhibition . And β-Amyrin palmitate has anti-diabetes mellitus activity .

HY-N0504R

Lovastatin (Standard) 20+ Cited Publications Mevinolin (Standard)	HMG-CoA Reductase (HMGCR) Autophagy Ferroptosis	Cardiovascular Disease Cancer
Lovastatin (Standard) is the analytical standard of Lovastatin. This product is intended for research and analytical applications. Lovastatin is a cell-permeable HMG-CoA reductase inhibitor used to lower cholesterol.

HY-17502R

Simvastatin (Standard) Maximum Cited Publications 47 Publications Verification MK 733 (Standard)	HMG-CoA Reductase (HMGCR) Autophagy Mitophagy Apoptosis Ferroptosis	Cardiovascular Disease Cancer
Simvastatin (Standard) is the analytical standard of Simvastatin. This product is intended for research and analytical applications. Simvastatin (MK 733) is a competitive inhibitor of HMG-CoA reductase with a K_i of 0.2 nM.

HY-17502S

Simvastatin-d11 MK 733-d₁₁	Apoptosis Autophagy Ferroptosis HMG-CoA Reductase (HMGCR) Mitophagy Isotope-Labeled Compounds	Cardiovascular Disease Cancer
Simvastatin-d₁₁ is the deuterium labeled Simvastatin. Simvastatin (MK 733) is a competitive inhibitor of HMG-CoA reductase with a Ki of 0.2 nM[1][2].

HY-101873

Atorvastatin lactone	HMG-CoA Reductase (HMGCR)	Metabolic Disease Inflammation/Immunology
Atorvastatin lactone is a proagent form of atorvastatin. Atorvastatin is an orally active 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor .

HY-108774

Rosuvastatin zinc salt Rosuvastatin zinc	Others	Cardiovascular Disease Metabolic Disease
Rosuvastatin zinc salt (Rosuvastatin zinc) is a zinc-containing form of Rosuvastatin (HY-17504A). Rosuvastatin is a HMG-CoA reductase inhibitor and can be used for atherosclerosis research .

HY-121795

Pravastatin lactone	HMG-CoA Reductase (HMGCR)	Cardiovascular Disease
Pravastatin lactone is a potent *HMG-CoA* inhibitor. Pravastatin Lactone is a metabolite of pravastatin. Pravastatin lactone reduces blood cholesterol levels by inhibiting cholesterol synthesis .

HY-136346

2-Hydroxy atorvastatin lactone	Drug Metabolite	Cardiovascular Disease
2-Hydroxy atorvastatin lactone is a metabolite of Atorvastatin. Atorvastatin is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids .

Cat. No.	Product Name

HY-L012

Metabolism/Protease Compound Library

4,571 compounds

Metabolism is the set of life-sustaining chemical reactions in organisms. Metabolic pathways are enzyme-mediated biochemical reactions that lead to biosynthesis (anabolism) or breakdown (catabolism) of natural product small molecules within a cell or tissue. Acting as catalysts, enzymes are crucial to metabolism - they allow a reaction to proceed more rapidly - and they also allow the regulation of the rate of a metabolic reaction. Proteases are used throughout an organism for various metabolic processes. Proteases control a great variety of physiological processes that are critical for life, including the immune response, cell cycle, cell death, wound healing, food digestion, and protein and organelle recycling. Imbalances in metabolic activities have been found to be critical in a number of pathologies, such as cardiovascular diseases, inflammation, cancer, and neurodegenerative diseases.

MCE designs a unique collection of 4,571 Metabolism/Protease-related small molecules that act as a useful tool for drug discovery of metabolism-related diseases.

Cat. No.	Product Name	Type

HY-114294A

DL-3-Hydroxy-3-methylglutaryl coenzyme A disodium hydrate HMG-CoA disodium hydrate	Enzyme Substrates
DL-3-Hydroxy-3-methylglutaryl coenzyme A disodium hydrate is a disodium salt compound of HMG-CoA, is a intermediate of terpenes and ketone bodies. DL-3-Hydroxy-3-methylglutaryl coenzyme A disodium also involves in ester metabolism in vivo, as a precursor for cholesterol synthesis, and regulates cholesterol synthesis by coupling LDL receptor .

HY-141474

Glutaryl coenzyme A lithium	Enzyme Substrates
Glutaryl coenzyme A lithium is a Glutaryl coenzyme A derivative. Glutaryl coenzyme A is an important endogenous metabolites. Glutaryl coenzyme A lithium can be used in HMG-CoA or Glutaryl-CoA related experiment.

HY-N7392

Acetoacetyl-CoA	Biochemical Assay Reagents
Acetoacetyl CoA is the precursor of HMG-CoA in the mevalonate pathway. Acetoacetyl-CoA thiolase catalyzes the reaction to form acetoacetyl-CoA from two acetyl-CoA molecules. Acetoacetyl CoA is essential for cholesterol biosynthesis. Acetoacetyl-CoA is also a intermediate in the biological breakdown and synthesis of fatty acids .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-113342

7-Ketocholesterol 1 Publications Verification	Triterpenes Structural Classification Terpenoids Source classification Endogenous metabolite	Endogenous Metabolite p38 MAPK
7-Ketocholesterol is an oxidation product of cholesterol, widely present in atherosclerotic plaques, and has a stronger atherogenic effect than cholesterol. 7-Ketocholesterol can inhibit the rate-limiting enzymes involved in bile acid and cholesterol synthesis, such as cholesterol 7α-hydroxylase and HMG-CoA reductase. 7-Ketocholesterol exhibits pro-inflammatory effects both in vivo and in vitro and can induce cell apoptosis (apoptosis) .

HY-N0504

Lovastatin 20+ Cited Publications Mevinolin	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease Research Fields Cancer	HMG-CoA Reductase (HMGCR) Autophagy Ferroptosis
Lovastatin is a cell-permeable HMG-CoA reductase inhibitor used to lower cholesterol.

HY-B0165A

Pravastatin sodium 5 Publications Verification CS-514 sodium	Cardiovascular Disease Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease Research Fields Cancer	HMG-CoA Reductase (HMGCR) Autophagy Ferroptosis
Pravastatin sodium (CS-514 sodium) is an HMG-CoA reductase inhibitor against sterol synthesis with IC₅₀ of 5.6 μM.

HY-N2923

β-Amyrin acetate	Triterpenes Structural Classification Ficus exasperata Vahl Source classification Plants Moraceae	HMG-CoA Reductase (HMGCR) Fungal
β-Amyrin acetate is a triterpenoid with potent anti-inflammatory, antifungal, anti-diabetic, anti-hyperlipidemic activities. β-Amyrin acetate can inhibit *HMG-CoA* reductase activity by locating in the hydrophobic binding cleft of HMG CoA reductase .

HY-N0504R

Lovastatin (Standard) 20+ Cited Publications Mevinolin (Standard)	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease Research Fields Cancer	HMG-CoA Reductase (HMGCR) Autophagy Ferroptosis
Lovastatin (Standard) is the analytical standard of Lovastatin. This product is intended for research and analytical applications. Lovastatin is a cell-permeable HMG-CoA reductase inhibitor used to lower cholesterol.

HY-B0165AR

Pravastatin sodium (Standard) 4 Publications Verification CS-514 sodium (Standard)	Cardiovascular Disease Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease Research Fields Cancer	HMG-CoA Reductase (HMGCR) Autophagy Ferroptosis
Pravastatin (sodium) (Standard) is the analytical standard of Pravastatin (sodium). This product is intended for research and analytical applications. Pravastatin sodium (CS-514 sodium) is an HMG-CoA reductase inhibitor against sterol synthesis with IC₅₀ of 5.6 μM.

HY-W712674

*HMG-CoA* 3-Hydroxy-3-methylglutaryl-CoA	Human Gut Microbiota Metabolites Microorganisms Source classification Endogenous metabolite	Others
HMG-CoA is a product generated by the hydration reaction of (E)-3-methylglutaconyl-CoA (MG-CoA) catalyzed by methylglutaconyl-CoA hydratase (MGCH) .

HY-N10076

Ganomycin I	Structural Classification Microorganisms Source classification Phenols Polyphenols	HMG-CoA Reductase (HMGCR) Glucosidase HIV Protease
Ganomycin I is a dual inhibitor of α-Glucosidase and HMG-CoA reductase. Ganomycin I can also inhibits HIV protease. Ganomycin I exhibits anti-diabetic and anti-osteoclastogenesis effects .

HY-117780

Rawsonol	Structural Classification Microorganisms Source classification Phenols Polyphenols	HMG-CoA Reductase (HMGCR)
Rawsonol is a brominated diphenylmethane derivative obtained from the green alga Avrainuika rawsoni. Rawsonol exhibits inhibitory activity against 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, with activities related to cholesterol biosynthesis inhibition or other metabolic pathways involving HMG-CoA reductase activity .

HY-N2924

β-Amyrin palmitate	Triterpenes other families Classification of Application Fields Terpenoids Source classification Plants Disease Research Fields Endocrinology	HMG-CoA Reductase (HMGCR)
β-Amyrin palmitate shows HMG-CoA reductase inhibition . And β-Amyrin palmitate has anti-diabetes mellitus activity .

HY-W017522

Adipic acid	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease markers Endocrine diseases Metabolic Disease Endogenous metabolite Disease Research Fields Cardiovascular System Disorder Cancer	Drug Metabolite Endogenous Metabolite
Adipic acid is found to be associated with HMG-CoA lyase deficiency, carnitine-acylcarnitine translocase deficiency, malonyl-Coa decarboxylase deficiency, and medium Chain acyl-CoA dehydrogenase deficiency, which are inborn errors of metabolism.

HY-N11637

Ganoderenic acid K	Triterpenes Structural Classification Microorganisms Terpenoids Source classification	HMG-CoA Reductase (HMGCR)
Ganoderenic acid K is a natural product, that can be isolated from fruiting bodies of Ganoderma lucidum. Ganoderenic acid K shows strong inhibitory activity against HMG-CoA reductase (HMGCR) with IC₅₀ of 16.5 μM .

HY-125130

Hesperetin 7-O-glucoside	Structural Classification Flavonoids Classification of Application Fields Flavonones Source classification Phenols Polyphenols Metabolic Disease Plants Umbelliferae Disease Research Fields Carphephorus corymbosus (Nutt.) Torr. & A.Gray	HMG-CoA Reductase (HMGCR) Bacterial
Hesperetin 7-O-glucoside is produced by the enzymatic conversion of Hesperidin. Hesperetin 7-O-glucoside is a potent *human HMG-CoA* reductase inhibitor and also effectively inhibits the growth of Helicobacter pylori**. Antihypertensive effect .

HY-W017522R

Adipic acid (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification Disease markers Endocrine diseases Endogenous metabolite Cardiovascular System Disorder Cancer	Drug Metabolite Endogenous Metabolite
Adipic acid (Standard) is the analytical standard of Adipic acid. This product is intended for research and analytical applications. Adipic acid is found to be associated with HMG-CoA lyase deficiency, carnitine-acylcarnitine translocase deficiency, malonyl-Coa decarboxylase deficiency, and medium Chain acyl-CoA dehydrogenase deficiency, which are inborn errors of metabolism.

HY-N7392

Acetoacetyl-CoA	Human Gut Microbiota Metabolites Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Biochemical Assay Reagents
Acetoacetyl CoA is the precursor of HMG-CoA in the mevalonate pathway. Acetoacetyl-CoA thiolase catalyzes the reaction to form acetoacetyl-CoA from two acetyl-CoA molecules. Acetoacetyl CoA is essential for cholesterol biosynthesis. Acetoacetyl-CoA is also a intermediate in the biological breakdown and synthesis of fatty acids .

HY-B1189

Meglutol Dicrotalic acid; 3-Hydroxy-3-methylglutaric acid	Cardiovascular Disease Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Disease Research Fields	HMG-CoA Reductase (HMGCR) Autophagy Endogenous Metabolite
Meglutol is a lipid-lowering agent. Meglutol can reduces cholesterol, triglycerides, serum β-lipoprotein, and phospholipids, and inhibits the activity of HMG-CoA reductase (a rate-limiting enzyme in cholesterol biosynthesis). Meglutol can induce significant lipid oxidative damage in brain tissue. It is promising for research in the field of cardiovascular diseases and metabolic diseases .

HY-119695A

Simvastatin acid ammonium Tenivastatin ammonium	Cardiovascular Disease Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Disease Research Fields	HMG-CoA Reductase (HMGCR) Reactive Oxygen Species
Simvastatin acid (Tenivastatin) ammonium is a potent HMG-CoA reductase (HMGCR) inhibitor. Simvastatin acid ammonium reduces Indoxyl sulfate-mediated reactive oxygen species (ROS) production in human cardiomyocytes. Simvastatin acid ammonium can also modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene .

HY-17408

Mevastatin 5+ Cited Publications Compactin; ML236B	Infection Cardiovascular Disease Structural Classification Natural Products Microorganisms Neurological Disease Classification of Application Fields Source classification Metabolic Disease Disease Research Fields	HMG-CoA Reductase (HMGCR) Bacterial Autophagy Apoptosis Antibiotic
Mevastatin (Compactin) is a first HMG-CoA reductase inhibitor that belongs to the statins class. Mevastatin is a lipid-lowering agent, and induces apoptosis, arrests cancer cells in G₀/G₁ phase. Mevastatin also increases endothelial nitric oxide synthase (eNOS) mRNA and protein levels. Mevastatin has antitumor activity and has the potential for cardiovascular diseases treatment .

HY-112490

Atorvastatin calcium hydrate Maximum Cited Publications 38 Publications Verification	Cardiovascular Disease Classification of Application Fields Disease Research Fields	HMG-CoA Reductase (HMGCR)
Atorvastatin calcium salt trihydrate is a drug belonging to the statin class of drugs used to lower blood cholesterol levels. Atorvastatin calcium salt trihydrate has unique chemical properties that make it an effective tool in controlling high levels of low-density lipoprotein (LDL) cholesterol and triglycerides in the body, reducing the risk of heart attack and stroke. Atorvastatin calcium salt trihydrate works by inhibiting HMG-CoA reductase, the enzyme responsible for producing cholesterol in the liver.

HY-119695AR

Simvastatin acid ammonium (Standard)	Structural Classification Ketones, Aldehydes, Acids Source classification Endogenous metabolite	HMG-CoA Reductase (HMGCR) Reactive Oxygen Species
Simvastatin acid (ammonium) (Standard) is the analytical standard of Simvastatin acid (ammonium). This product is intended for research and analytical applications. Simvastatin acid (Tenivastatin) ammonium is a potent HMG-CoA reductase (HMGCR) inhibitor. Simvastatin acid ammonium reduces Indoxyl sulfate-mediated reactive oxygen species (ROS) production in human cardiomyocytes. Simvastatin acid ammonium can also modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene .

HY-129149

Ganoderic acid SZ	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification	Others
Ganoderic acid SZ is a natural product with 3-hydroxy-3-methylglutaryl-CoA reductase inhibitory activity. Ganoderic acid SZ shows stronger activity than the positive control atorvastatin in inhibiting HMG-CoA reductase. Ganoderic acid SZ exhibits significant inhibition of yeast-derived α-glucosidase with IC50 values achieved at very low concentrations. Ganoderic acid SZ also exhibits cytotoxicity against K562 cells with IC?? values in the range of 10-20 μM .

HY-17504A

Rosuvastatin ZD 4522	Classification of Application Fields Disease Research Fields Cancer	HMG-CoA Reductase (HMGCR) Autophagy Potassium Channel Bacterial
Rosuvastatin (ZD 4522) is a competitive *HMG-CoA* reductase inhibitor with an IC₅₀ of 11 nM. Rosuvastatin potently blocks hERG current with an IC₅₀ of 195 nM, delayed cardiac repolarization, and thereby prolonged action potential durations (APDs) and corrected QT interval (QTc) intervals. Rosuvastatin reduces the expression of the mature hERG and the interaction of heat shock protein 70 (Hsp70) with the hERG protein. Rosuvastatin effectively lowers low-density lipoprotein (LDL) cholesterol, triglycerides, and C-reactive protein levels .

HY-W020033

Lanosterol 3 Publications Verification	Triterpenes Structural Classification Human Gut Microbiota Metabolites Microorganisms Terpenoids Source classification Endogenous metabolite	Endogenous Metabolite
Lanosterol is an intermediate of cholesterol synthesis and use of lanosterol induces ubiquitination and degradation of a rate-controlling enzyme of cholesterol synthesis, i.e., HMG CoA reductase. Lanosterol suppresses the aggregation and cytotoxicity of misfolded proteins linked with neurodegenerative diseases .

HY-100313

YM-53601 free base	Structural Classification Alkaloids Carbazole Alkaloids	Farnesyl Transferase HCV
YM-53601 free base, a squalene synthase inhibitor, reduces plasma cholesterol and triglyceride levels in vivo . YM-53601 free base inhibits squalene synthase derived from human hepatoma cells with an IC₅₀ of 79 nM. Lipid-lowering agent . YM-53601 free base is also an inhibitor of farnesyl-diphosphate farnesyltransferase 1 (FDFT1) enzyme activity and abrogates HCV propagation .

Cat. No.	Compare	Product Name	Species	Source

HY-P72228

	HMGCR Protein, Human (His) 3 hydroxy 3 methylglutaryl CoA Reductase; 3 hydroxy 3 methylglutaryl Coenzyme A Reductase; 3 hydroxymethylglutaryl CoA Reductase; 3-hydroxy-3-methylglutaryl CoA Reductase NADPH; ; 3-hydroxy-3-methylglutaryl-coenzyme A Reductase; 3H3M; HMDH_HUMAN; HMG CoA Reductase; HMG CoAR; HMG-CoA Reductase; HMGcr; Hydroxymethylglutaryl CoA Reductase; LDLCQ3; MGC103269; Red	Human	E. coli
	As a key enzyme in cholesterol biosynthesis, HMGCR protein plays a central role in regulating cellular cholesterol levels. It catalyzes the conversion of HMG-CoA to mevalonate, a key step in the synthesis of cholesterol and other isoprenoids. HMGCR Protein, Human (His) is the recombinant human-derived HMGCR protein, expressed by E. coli , with N-6*His labeled tag.

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Cat. No.	Product Name	Chemical Structure

HY-14664AS

Fluvastatin-d6 sodium
Fluvastatin-d₆ (sodium) is deuterium labeled Fluvastatin sodium. Fluvastatin sodium (XU 62320) is a first fully synthetic, competitive HMG-CoA reductase inhibitor with an IC50 of 8 nM.

HY-B0144AS

Pitavastatin D4
Pitavastatin-d₄ is deuterium labeled Pitavastatin. Pitavastatin is a potent HMG-CoA reductase inhibitor.

HY-N0504S1

Lovastatin-d9
Lovastatin-d₉ is the deuterium labeled Lovastatin. Lovastatin is a cell-permeable HMG-CoA reductase inhibitor used to lower cholesterol.

HY-N0504S2

Lovastatin-d3
Lovastatin-d₃ is deuterium labeled Lovastatin. Lovastatin is a cell-permeable HMG-CoA reductase inhibitor used to lower cholesterol.

HY-17502S

Simvastatin-d11
Simvastatin-d₁₁ is the deuterium labeled Simvastatin. Simvastatin (MK 733) is a competitive inhibitor of HMG-CoA reductase with a Ki of 0.2 nM[1][2].

HY-17502S1

Simvastatin-d3
Simvastatin-d₃ is the deuterium labeled Simvastatin[1]. Simvastatin (MK 733) is a competitive inhibitor of HMG-CoA reductase with a Ki of 0.2 nM[2].

HY-123672S

Lovastatin-d3 hydroxy acid sodium
Lovastatin-d₃ hydroxy acid (sodium) is the deuterium labeled Lovastatin hydroxy acid sodium. Lovastatin hydroxy acid sodium (Mevinolinic acid sodium) is a highly potent inhibitor of HMG-CoA reductase with a Ki of 0.6 nM[1].

HY-B0165CS

Pravastatin-d3 sodium salt
Pravastatin-d₃ (sodium) is the deuterium labeled Pravastatin sodium salt. Pravastatin (CS-514) sodium salt is a competitive HMG-CoA reductase inhibitor against sterol synthesis with IC50 of 5.6 μM[1][2].

HY-B0165AS

Pravastatin-13C,d3 sodium
Pravastatin- ¹³C,d₃ (sodium) is the ¹³C- and deuterium labeled Pravastatin (sodium). Pravastatin sodium (CS-514 sodium) is an HMG-CoA reductase inhibitor against sterol synthesis with IC50 of 5.6 μM.

HY-B0165S

Pravastatin-d9 sodium
Pravastatin-d₉ sodium is deuterated labeled Pravastatin (HY-B0165). Pravastatin (CS-514) is a competitive HMG-CoA reductase inhibitor against sterol synthesis with IC₅₀ of 5.6 μM .

HY-14664DS

(3S,5R)-Fluvastatin-d6
(3S,5R)-Fluvastatin-d₆ is the deuterium labeled (3S,5R)-Fluvastatin sodium. Fluvastatin is a first fully synthetic, competitive HMG-CoA reductase inhibitor with an IC50 of 8 nM. Fluvastatin protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway[1].

HY-101873S

Atorvastatin lactone-d5
Atorvastatin lactone-d₅ is a deuterated form of Atorvastatin lactone (HY-101873). Atorvastatin lactone is a proagent form of atorvastatin. Atorvastatin is an orally active 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor[1].

HY-W017522S6

Adipic acid-13C2
Adipic acid- ¹³C₂ is ¹³C labeled Adipic acid. Adipic acid is found to be associated with HMG-CoA lyase deficiency, carnitine-acylcarnitine translocase deficiency, malonyl-Coa decarboxylase deficiency, and medium Chain acyl-CoA dehydrogenase deficiency, which are inborn errors of metabolism.

HY-136346S

Ortho-hydroxy atorvastatin lactone-d5
Ortho-hydroxy atorvastatin lactone-d₅ is deuterium labeled 2-Hydroxy atorvastatin lactone. 2-Hydroxy atorvastatin lactone is a metabolite of Atorvastatin. Atorvastatin is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids[1][2].

HY-W017522S3

Adipic acid-13C
Adipic acid- ¹³C is the ¹³C labeled Adipic acid[1]. Adipic acid is found to be associated with HMG-CoA lyase deficiency, carnitine-acylcarnitine translocase deficiency, malonyl-Coa decarboxylase deficiency, and medium Chain acyl-CoA dehydrogenase deficiency, which are inborn errors of metabolism[2].

HY-W017522S

Adipic acid-d10
Adipic acid-d₁₀ is the deuterium labeled Adipic acid[1]. Adipic acid is found to be associated with HMG-CoA lyase deficiency, carnitine-acylcarnitine translocase deficiency, malonyl-Coa decarboxylase deficiency, and medium Chain acyl-CoA dehydrogenase deficiency, which are inborn errors of metabolism[2].

HY-W017522S1

Adipic acid-13C6
Adipic acid- ¹³C₆ is the ¹³C labeled Adipic acid[1]. Adipic acid is found to be associated with HMG-CoA lyase deficiency, carnitine-acylcarnitine translocase deficiency, malonyl-Coa decarboxylase deficiency, and medium Chain acyl-CoA dehydrogenase deficiency, which are inborn errors of metabolism[2].

HY-W017522S2

Adipic acid-d4
Adipic acid-d₄ is the deuterium labeled Adipic acid[1]. Adipic acid is found to be associated with HMG-CoA lyase deficiency, carnitine-acylcarnitine translocase deficiency, malonyl-Coa decarboxylase deficiency, and medium Chain acyl-CoA dehydrogenase deficiency, which are inborn errors of metabolism[2].

HY-W017522S4

Adipic acid-d8
Adipic acid-d₈ is the deuterium labeled Adipic acid[1]. Adipic acid is found to be associated with HMG-CoA lyase deficiency, carnitine-acylcarnitine translocase deficiency, malonyl-Coa decarboxylase deficiency, and medium Chain acyl-CoA dehydrogenase deficiency, which are inborn errors of metabolism[2].

HY-W017522S5

Adipic acid-d4-1
Adipic acid-d₄-1 is the deuterium labeled Adipic acid[1]. Adipic acid is found to be associated with HMG-CoA lyase deficiency, carnitine-acylcarnitine translocase deficiency, malonyl-Coa decarboxylase deficiency, and medium Chain acyl-CoA dehydrogenase deficiency, which are inborn errors of metabolism[2].

HY-B0589S1

Atorvastatin-d5 sodium
Atorvastatin-d₅ (sodium) is the deuterium labeled Atorvastatin sodium. Atorvastatin sodium is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids. Atorvastatin sodium inhibits human SV-SMC proliferation and invasion with IC50s of 0.39 μM and 2.39 μM, respectively[1][2][3][4].

HY-B0589S

Atorvastatin-d5 hemicalcium
Atorvastatin-d₅ (hemicalcium) is the deuterium labeled Atorvastatin. Atorvastatin hemicalcium is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids. Atorvastatin hemicalcium inhibits human SV-SMC proliferation and invasion with IC50s of 0.39 μM and 2.39 μM, respectively[1][2][3].

HY-B0144AS1

Pitavastatin-d5 sodium
Pitavastatin-d₅ (sodium) is the deuterium labeled Pitavastatin sodium. Pitavastatin (NK-104) is a potent hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitor. Pitavastatin inhibits cholesterol synthesis from acetic acid with an IC50 of 5.8 nM in HepG2 cells. Pitavastatin is an efficient hepatocyte low-density lipoprotein-cholesterol (LDL-C) receptor inducer. Anti-cancer activity.

HY-17504AS

Rosuvastatin-d3
Rosuvastatin-d₃ is a deuterium labeled Rosuvastatin. Rosuvastatin (ZD 4522) is a competitive HMG-CoA reductase inhibitor with an IC50 of 11 nM[1]. Rosuvastatin potently blocks human ether-a-go-go related gene (hERG) current with an IC50 of 195 nM, delayed cardiac repolarization, and thereby prolonged action potential durations (APDs) and corrected QT interval (QTc) intervals[2].

HY-109523S

Cerivastatin-d3 sodium

Cerivastatin-d₃ sodium is deuterated labeled Cerivastatin sodium (HY-109523). Cerivastatin sodium is a synthetic lipid-lowering agent and a highly potent, well-tolerated and orally active HMG-CoA reductase inhibitor, with a Ki of 1.3 nM/L. Cerivastatin sodium reduces low-density lipoprotein cholesterol levels. Cerivastatin sodium also inhibits proliferation and invasiveness of MDA-MB-231 cells, mainly by RhoA inhibition, and has anti-cancer effect .

HY-119695AS1

Simvastatin acid-d9 ammonium

Simvastatin acid-d₉ ammonium is deuterated labeled Simvastatin acid ammonium (HY-119695A). Simvastatin acid (Tenivastatin) ammonium is a potent HMG-CoA reductase (HMGCR) inhibitor. Simvastatin acid ammonium reduces Indoxyl sulfate-mediated reactive oxygen species (ROS) production in human cardiomyocytes. Simvastatin acid ammonium can also modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene .

HY-B0144S

Pitavastatin-d4 hemicalcium

Pitavastatin-d₄ (hemicalcium) is deuterium labeled Pitavastatin (Calcium). Pitavastatin Calcium (NK-104 hemicalcium) is a potent hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitor. Pitavastatin Calcium (NK-104 hemicalcium) inhibits cholesterol synthesis from acetic acid with an IC50 of 5.8 nM in HepG2 cells. Pitavastatin Calcium is an efficient hepatocyte low-density lipoprotein-cholesterol (LDL-C) receptor inducer. Anti-cancer activity[1][2][3].

HY-17504BS2

Rosuvastatin-13C,d3 sodium

Rosuvastatin- ¹³C,d₃ sodium is ¹³C and deuterated labeled Rosuvastatin sodium (HY-17504B). Rosuvastatin Sodium is a competitive HMG-CoA reductase (HMGCR) inhibitor, with an IC₅₀ of 11 nM. Rosuvastatin Sodium potently blocks hERG current with an IC₅₀ of 195 nM . Rosuvastatin Sodium reduces the expression of the mature hERG and the interaction of heat shock protein 70 (Hsp70) with the hERG protein. Rosuvastatin Sodium effectively lowers low-density lipoprotein (LDL) cholesterol, triglycerides, and C-reactive protein levels .

HY-W020033S

Lanosterol-d6
Lanosterol-d₆ is deuterium labeled Lanosterol. Lanosterol is an intermediate of cholesterol synthesis and use of lanosterol induces ubiquitination and degradation of a rate-controlling enzyme of cholesterol synthesis, i.e., HMG CoA reductase. Lanosterol s

HY-14664CS

(3S,5R)-Fluvastatin-d6 sodium
(3S,5R)-Fluvastatin-d₆ (sodium) is the deuterium labeled (3S,5R)-Fluvastatin sodium. Fluvastatin is a first fully synthetic, competitive HMG-CoA reductase inhibitor with an IC50 of 8 nM. Fluvastatin protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway[1].

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P81197

	HMGCR Antibody 3 hydroxy 3 methylglutaryl CoA Reductase antibody; 3 hydroxy 3 methylglutaryl Coenzyme A Reductase antibody; 3 hydroxymethylglutaryl CoA Reductase antibody; 3-hydroxy-3-methylglutaryl CoA Reductase (NADPH) antibody; 3-hydroxy-3-methylglutaryl-coenzyme A Reductase antibody; 3H3M antibody; HMDH_HUMAN antibody; HMG CoA Reductase antibody; HMG CoAR antibody; HMG-CoA Reductase antibody; HMGcr antibody; Hydroxymethylglutaryl CoA Reductase antibody; LDLCQ3 antibody; MGC103269 antibody; Red antibody	WB, IP	Human, Mouse
	HMGCR Antibody is an unconjugated, approximately 97 kDa, rabbit-derived, anti-HMGCR monoclonal antibody. HMGCR Antibody can be used for: WB,IP expriments in human, mouse background without labeling.