Search Result

Results for "

LPS stimulate

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adrenergic Receptor (1) AIM2 (1) Akt (1) AMPK (3) Amyloid-β (2) Angiotensin Receptor (1) Antibiotic (2) Apoptosis (2) Bacterial (6) Casein Kinase (3) COX (12) Cytochrome P450 (1) Endogenous Metabolite (8) ERK (1) Flavivirus (2) Formyl Peptide Receptor (FPR) (1) Fungal (3) HDAC (1) IKK (1) Indoleamine 2,3-Dioxygenase (IDO) (1) Interleukin Related (9) IRAK (1) Isotope-Labeled Compounds (1) JNK (1) Keap1-Nrf2 (2) Leukotriene Receptor (1) MAP3K (1) Microtubule/Tubulin (1) Monoamine Oxidase (1) NF-κB (18) NO Synthase (10) NOD-like Receptor (NLR) (1) P2Y Receptor (3) p38 MAPK (8) Parasite (2) PGE synthase (1) PI3K (1) PPAR (1) Pyroptosis (1) Reactive Oxygen Species (2) TGF-beta/Smad (1) Thyroid Hormone Receptor (2) TNF Receptor (9) Toll-like Receptor (TLR) (3)
By Research Areas:	Cancer (13) Cardiovascular Disease (3) Endocrinology (3) Infection (6) Inflammation/Immunology (67) Metabolic Disease (2) Neurological Disease (7)

By Targets:

Adrenergic Receptor (1)

AIM2 (1)

Akt (1)

AMPK (3)

Amyloid-β (2)

Angiotensin Receptor (1)

Antibiotic (2)

Apoptosis (2)

Bacterial (6)

Casein Kinase (3)

COX (12)

Cytochrome P450 (1)

Endogenous Metabolite (8)

ERK (1)

Flavivirus (2)

Formyl Peptide Receptor (FPR) (1)

Fungal (3)

HDAC (1)

IKK (1)

Indoleamine 2,3-Dioxygenase (IDO) (1)

Interleukin Related (9)

IRAK (1)

Isotope-Labeled Compounds (1)

JNK (1)

Keap1-Nrf2 (2)

Leukotriene Receptor (1)

MAP3K (1)

Microtubule/Tubulin (1)

Monoamine Oxidase (1)

NF-κB (18)

NO Synthase (10)

NOD-like Receptor (NLR) (1)

P2Y Receptor (3)

p38 MAPK (8)

Parasite (2)

PGE synthase (1)

PI3K (1)

PPAR (1)

Pyroptosis (1)

Reactive Oxygen Species (2)

TGF-beta/Smad (1)

Thyroid Hormone Receptor (2)

TNF Receptor (9)

Toll-like Receptor (TLR) (3)

By Research Areas:

Cancer (13)

Cardiovascular Disease (3)

Endocrinology (3)

Infection (6)

Inflammation/Immunology (67)

Metabolic Disease (2)

Neurological Disease (7)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N10120

Methylsyringin	Others	Inflammation/Immunology
Methylsyringin exhibits anti-inflammatory activity in the LPS-stimulated RAW264.7 cells.

HY-124789

TBT1	Bacterial Antibiotic	Infection
TBT1 is a first-generation inhibitor of the MsbA transporter. TBT1 is an LPS transport inhibitor and MsbA ATPase stimulator in strains from the Acinetobacter genus. TBT1 stimulated ATPase activity with an EC₅₀ of 13 µM .

HY-N1380

Guaiacol 2-Methoxyphenol	COX NF-κB Endogenous Metabolite	Inflammation/Immunology
Guaiacol, a phenolic compound, inhibits LPS-stimulated COX-2 expression and NF-κB activation . Anti-inflammatory activity .

HY-N0358

1,4-Dicaffeoylquinic acid 1 Publications Verification 1,4-DCQA	TNF Receptor Interleukin Related	Inflammation/Immunology
1,4-Dicaffeoylquinic acid (1,4-DCQA) is a phenylpropanoid from Xanthii fructus, inhibits LPS-stimulated TNF-α production .

HY-153579

Anti-inflammatory agent 42	Interleukin Related	Inflammation/Immunology
Anti-inflammatory agent 42 (Compound 10j) is an anti-inflammatory agent. Anti-inflammatory agent 42 shows excellent inhibition on the expression of TNF-α and IL-6 in LPS (HY-D1056)-stimulated macrophages .

HY-N3473

Isomaculosidine	NO Synthase	Neurological Disease
Isomaculosidine is an alkaloid that can be isolated from D. dasycarpus. Isomaculosidine can inhibit nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated BV2 microglial cells .

HY-N3480

Isogosferol (+)-Isogospherol; Isogospherol	Others	Inflammation/Immunology
Isogosferol ((+)-Isogospherol; Isogospherol) is a potent anti-inflammatory agent. Isogosferol decreases LPS (HY-D1056)-stimulated NO and IL-1β expression. Isogosferol decreases the LPS (HY-D1056)-stimulated expression of iNOS, COX-2, NF-κB, and pERK1/2 .

HY-133098

Juncutol	NO Synthase	Inflammation/Immunology
Juncutol is a potent inducible nitric oxide synthase (iNOS) inhibitor. Juncutol decreases the LPS (HY-D1056)-stimulated iNOS protein expression .

HY-N1080

Vitexdoin A	Others	Inflammation/Immunology
Vitexdoin A is a nitric oxide scavenging lignin. Vitexdoin A inhibits NO production with an IC₅₀ of 0.38 μM in LPS (HY-D1056)-stimulated RAW 264.7 cells .

HY-N13175

Panaxcerol B	NO Synthase	Cancer
Panaxcerol B is a monogalactosyl monoacylglyceride, with an IC₅₀ of 59.4 μM for NO production in LPS-stimulated RAW264.7 cells .

HY-N8277

Kdo2-Lipid A ammonium 2 Publications Verification	Toll-like Receptor (TLR) TNF Receptor	Cancer
Kdo2-Lipid A ammonium is a chemically defined lipopolysaccharide (LPS) with endotoxin activity equal to LPS. Kdo2-Lipid A ammonium is highly selective for TLR4. Kdo2-Lipid A ammonium stimulates the release of both TNF and PGE2 .

HY-124508

Lambertellin	Antibiotic Bacterial Fungal p38 MAPK NF-κB	Infection Inflammation/Immunology
Lambertellin is an effective antibiotic that can be used as a bactericide and as a fungicide. Lambertellin exerts its anti-inflammatory effect in LPS (HY-D1056)-stimulated RAW 264.7 macrophage cells by modulating the activation of the MAPK and NF-κB signaling pathways .

HY-146971

Anti-inflammatory agent 38	NO Synthase Reactive Oxygen Species	Inflammation/Immunology
Anti-inflammatory agent 38 (compound 23d) is a potent Nrf2/HO-1 pathway inhibitor, with an IC₅₀ value of 0.38 μM for NO. Anti-inflammatory agent 38 can significantly reduce the level of ROS in cells. Anti-inflammatory agent 38 can be used for researching anti-inflammatory .

HY-132248

C5 Lenalidomide Lenalidomide 5'-amine	TNF Receptor	Inflammation/Immunology
C5 Lenalidomide (Lenalidomide 5'-amine) is a thalidomide analog and is a potent inhibitor of TNF-alpha production (IC₅₀=100 μM in LPS stimulated human PBMC) .

HY-N2989

3-O-Acetyl-16α-hydroxydehydrotrametenolic acid	NO Synthase	Inflammation/Immunology
3-O-Acetyl-16α-hydroxydehydrotrametenolic acid, an anti-inflammatory triterpenoid, inhibits NO production and iNOS expression in LPS-stimulated Raw264.7 cells .

HY-N9891

12-Dehydrogingerdione 12-DHGD	NO Synthase Interleukin Related	Inflammation/Immunology
12-Dehydrogingerdione is an inhibitor of NO Synthase. 12-Dehydrogingerdione signi?cantly inhibits LPS-stimulated production of NO, IL-6 and PGE2 in Raw 264.7 cells .

HY-169340

SAR-150640	Adrenergic Receptor	Inflammation/Immunology
SAR-150640, a selective β₃-adrenoceptor agonist, prevents the increase in MMP activity and production observed after LPS stimulation or in cases of chorioamnionitis .

HY-118984

CRX-526	Toll-like Receptor (TLR)	Inflammation/Immunology
CRX-526 is a TLR4 antagonist that can block the interaction of lipopolysaccharide (LPS, HY-D1056) with the immune system, including preventing the expression of pro-inflammatory genes stimulated by LPS, as well as blocking the release of TNF-α induced by LPS. CRX-526 exhibits anti-inflammatory effects in two mouse models of colitis (namely, the dextran sodium sulfate-induced colitis model and the multidrug resistance gene 1a-deficient mouse model) .

HY-N2495

Isomucronulatol	Others	Inflammation/Immunology
Isomucronulatol is a flavonoid isolated from the roots of A. membranaceus. Isomucronulatol exhibits inhibitory effects on LPS-stimulated production IL-12 p40 in vitro and has potential anti-inflammatory effect .

HY-N1494

(+)-14-Deoxy-ε-caesalpin 14-Deoxy-ε-caesalpin	NO Synthase	Inflammation/Immunology
(+)-14-Deoxy-ε-caesalpin (14-Deoxy-ε-caesalpin), a cassane diterpenoid, inhibits nitric oxide (NO) production release of RAW 264.7 cells stimulated by Lipopolysaccharide (LPS) .

HY-N1912

Andropanolide	Others	Cancer
Andropanolide is a natural product that exerts cytotoxicity toward carcinoma cells and significantly inhibits the overproduction of nitric oxide (NO) in Lipopolysaccharides (HY-D1056) (LPS)-stimulated RAW264.7 macrophages .

HY-138050

Nyasol (-)-Nyasol; (Z)-Hinokiresinol; cis-Hinokiresinol	NO Synthase Bacterial Fungal Parasite Leukotriene Receptor	Infection Inflammation/Immunology
Nyasol ((-)-Nyasol) is an active compound that has antifungal, antibacterial, antileishmanial, hyaluronidase inhibition activities. Nyasol inhibits LTB4 binding to human neutrophils. Nyasol suppresses neuroinflammatory response through the inhibition of I-κB degradation in LPS (HY-D1056)-stimulated BV-2 microglial cells .

HY-N1380S1

Guaiacol-d3 2-Methoxyphenol-d₃	Isotope-Labeled Compounds COX NF-κB	Inflammation/Immunology
Guaiacol-d₃ is the deuterium labeled Guaiacol. Guaiacol, a phenolic compound, inhibits LPS-stimulated COX-2 expression and NF-κB activation. Guaiacol has an anti-inflammatory activity[1].

HY-108661

NF546	P2Y Receptor	Inflammation/Immunology
NF546 is a selective non-nucleotide P2Y11 agonist with a pEC₅₀ of 6.27. NF546 stimulates release of interleukin-8 from human monocyte-derived dendritic cells .

HY-108661A

NF546 hydrate	P2Y Receptor	Inflammation/Immunology
NF546 (hydrate) is a selective non-nucleotide P2Y11 agonist with a pEC₅₀ of 6.27. NF546 (hydrate) stimulates release of interleukin-8 from human monocyte-derived dendritic cells .

HY-N1195

Sugiol (+)-Sugiol; 10-Deoxoxanthoperol	p38 MAPK ERK JNK Interleukin Related TNF Receptor	Inflammation/Immunology
Sugiol is an abietane diterpenoid, can be isolated from Calocedrus formosana bark. Sugiol has anti-inflammatory activity, could effectively reduce intracellular reactive oxygen species (ROS) production in lipopolysaccharide (LPS)-stimulated macrophages .

HY-N1380R

Guaiacol (Standard) 2-Methoxyphenol (Standard)	COX Endogenous Metabolite NF-κB	Inflammation/Immunology
Guaiacol (Standard) is the analytical standard of Guaiacol. This product is intended for research and analytical applications. Guaiacol, a phenolic compound, inhibits LPS-stimulated COX-2 expression and NF-κB activation . Anti-inflammatory activity .

HY-N0589

Dehydrodiisoeugenol 1 Publications Verification	NF-κB COX Bacterial	Infection Inflammation/Immunology
Dehydrodiisoeugenol is isolated from Myristica fragrans Houtt, shows anti-inflammatory and anti-bacterial actions . Dehydrodiisoeugenol inhibits LPS- stimulated NF-κB activation and cyclooxygenase (COX)-2 gene expression in murine macrophages .

HY-N1380S

Guaiacol-d7 2-Methoxyphenol-d₇	COX NF-κB Endogenous Metabolite	Inflammation/Immunology
Guaiacol-d₇ is the deuterium labeled Guaiacol[1]. Guaiacol, a phenolic compound, inhibits LPS-stimulated COX-2 expression and NF-κB activation[1]. Anti-inflammatory activity[2].

HY-N1380S3

Guaiacol-d4 2-Methoxyphenol-d₄	COX NF-κB Endogenous Metabolite	Inflammation/Immunology
Guaiacol-d₄ is the deuterium labeled Guaiacol[1]. Guaiacol, a phenolic compound, inhibits LPS-stimulated COX-2 expression and NF-κB activation[1]. Anti-inflammatory activity[2].

HY-N1380S2

Guaiacol-13C6 2-Methoxyphenol-¹³C₆	COX NF-κB Endogenous Metabolite	Inflammation/Immunology
Guaiacol- ¹³C₆ is the ¹³C labeled Guaiacol[1]. Guaiacol, a phenolic compound, inhibits LPS-stimulated COX-2 expression and NF-κB activation[1]. Anti-inflammatory activity[2].

HY-N1380S4

Guaiacol-d4-1 2-Methoxyphenol-d₄-1	COX NF-κB Endogenous Metabolite	Inflammation/Immunology
Guaiacol-d₄-1 is the deuterium labeled Guaiacol[1]. Guaiacol, a phenolic compound, inhibits LPS-stimulated COX-2 expression and NF-κB activation[1]. Anti-inflammatory activity[2].

HY-115770

8-Methylsulfinyloctyl isothiocyanate	Bacterial	Inflammation/Immunology
8-Methylsulfinyloctyl isothiocyanate, an isothiocyanate, has antimicrobial activity and remarkable inhibitory activity against plant growth . 8-Methylsulfinyloctyl isothiocyanate impair COX-2 mediated inflammatory responses in LPS stimulated raw macrophages .

HY-N4233

Bisabolangelone	p38 MAPK	Inflammation/Immunology
Bisabolangelone, a sesquiterpene derivative, is isolated from the roots of Osterici Radix. Bisabolangelone possesses anti-inflammatory properties, which inhibits LPS-stimulated inflammation through the blocking of NF-kappaB and MAPK pathways in macrophages. Bisabolangelone has anti-ulcer activities .

HY-N12494

Diplacol	NO Synthase	Inflammation/Immunology
Diplacol is a geranylated flavanone that can be isolated from paulownia trees (Paulownia coreana UYEKI). Diplacol has anti-inflammatory activity. Diplacol inhibits NO production in LPS-stimulated Raw264.7 cells with an IC₅₀ value of 4.53 μM .

HY-N8719

Pratol 7-Hydroxy-4'-methoxyflavone	NF-κB	Inflammation/Immunology
Pratol is a potent inhibitor of NF-κB. Pratol significantly reduces NO and prostaglandin PGE2 production without any cytotoxic in LPS-stimulated RAW 264.7 cells. Pratol reduces proinflammatory cytokines. Pratol can be used in study inflammatory diseases and cancer .

HY-N0602

Ginsenoside Rg2 3 Publications Verification Chikusetsusaponin I; Panaxoside Rg2; Prosapogenin C2	NF-κB Amyloid-β	Cardiovascular Disease Neurological Disease Cancer
Ginsenoside Rg2 is one of the major active components of ginseng. Ginsenoside Rg2 inhibits VCAM-1 and ICAM-1 expressions stimulated with lipopolysaccharide (LPS). Ginsenoside Rg2 also reduces Aβ_1-42 accumulation.

HY-N6250

Isomucronulatol 7-O-glucoside Isomucronulatol 7-O-β-glucoside	Others	Inflammation/Immunology
Isomucronulatol 7-O-glucoside is a flavonoid isolated from the roots of A. membranaceus. Isomucronulatol 7-O-glucoside exhibits weak inhibitory effects on LPS-stimulated production IL-12 p40 in vitro and has potential anti-inflammatory effect .

HY-N10175

Berkeleyacetal C	Fungal Endogenous Metabolite	Inflammation/Immunology
Berkeleyacetal C, a meroterpenoid compound, shows favorable activity of inhibiting nitrogen oxide (NO) production of macrophages stimulated by lipopolysaccharide (LPS). Berkeleyacetal C exerts anti-inflammatory effects via inhibiting NF-κB, ERK1/2 and IRF3 signaling pathways .

HY-W573700

Methyl everninate	Others	Others
Methyl everninate is the major constituent of the deuterochloroform. Methyl everninate, rhodomollosides A and B are the derivatives of Methyl everninate, with cytotoxicity against RAW264.7 cells. Both of they shows inhibitory effects with a lipopolysaccharide (LPS)-stimulated murine macrophages RAW 264.7 cells model .

HY-167853

KR-31080 SK-1080	Angiotensin Receptor	Metabolic Disease
KR-31080 is an derivative of imidazo [4,5-b] pyridine. KR-31080 inhibits angiotensin II receptor. KR-31080 inhibits the NO production in LPS-stimulated BV-2 cells at a concentration of 2 μm with inhibition of 8.3% .

HY-N0358R

1,4-Dicaffeoylquinic acid (Standard)	TNF Receptor Interleukin Related	Inflammation/Immunology
1,4-Dicaffeoylquinic acid (Standard) is the analytical standard of 1,4-Dicaffeoylquinic acid. This product is intended for research and analytical applications. 1,4-Dicaffeoylquinic acid (1,4-DCQA) is a phenylpropanoid from Xanthii fructus, inhibits LPS-stimulated TNF-α production .

HY-N4061

Hedycoronen A	Interleukin Related	Inflammation/Immunology
Hedycoronen A has inhibitory activity on the IL-6, IL-12 p40, and TNF-α production in LPS-Stimulated BMDCs, with IC₅₀s of 9.1 μM, 5.6 μM, and 46.0 μM. Hedycoronen A can be isolated from Hedychium coronarium .

HY-N7422

Kauran-16,17-diol ent-Kauran-16β,17-diol	Apoptosis	Inflammation/Immunology Cancer
Kauran-16,17-diol (ent-Kauran-16β,17-diol), a natural diterpene, posseses anti-tumor and inducing-apoptosis activity, with a IC₅₀ of 17 μM on inhibiting NO production in LPS-stimulated RAW 264.7 macrophages .

HY-117921

DA-E 5090	Others	Inflammation/Immunology
DA-E 5090 is an orally effective inhibitor of IL-1 production that can be converted into a pharmacologically active deacetylated form (DA-E5090) in vivo. In this study, the effects of DA-E5090 on IL-1 production in vitro were examined by LPS-stimulated human monocytes. The results showed that DA-E5090 could dose-dependently inhibit the production of IL-1α and IL-1β (1-10 μM) by LPS-stimulated human monocytes, as determined by LAF assay and ELISA. Northern blotting analysis showed that DA-E5090 inhibited the transcription of IL-1α and IL-1β mRNA.

HY-B1201

Tiratricol 3,3',5-Triiodothyroacetic acid	Flavivirus Thyroid Hormone Receptor TNF Receptor	Endocrinology
Tiratricol is an orally available thyroid hormone analog that inhibits pituitary thyroid-stimulating hormone secretion. Tiratricol is an intracellular toxin neutralizer that inhibits LPS and lipid A cytotoxicity with IC₅₀s of 20 μM and 32 μM, respectively. Tiratricol reduces TNF production in lipopolysaccharide-stimulated macrophages. Tiratricol also has antiviral activity and is an inhibitor of yellow fever virus (Flavivirus). It can bind to the RdRp domain of the viral NS5 protein to hinder YFV replication. .

HY-163368

HDAC6-IN-34	HDAC	Inflammation/Immunology
HDAC6-IN-34 (compound 21) is an oral active and selective HDAC6 inhibitor with the IC₅₀ of 18 nM. HDAC6-IN-34 increases the acetylation level of tubulin without affecting histone acetylation in cutaneous T-cell lymphoma cells and inhibits TNF-α secretion in LPS (HY-D1056)-stimulated macrophage cells. HDAC6-IN-34 shows excellent anti-arthritic efficacy in rat .

HY-N0589R

Dehydrodiisoeugenol (Standard)	NF-κB COX Bacterial	Infection Inflammation/Immunology
Dehydrodiisoeugenol (Standard) is the analytical standard of Dehydrodiisoeugenol. This product is intended for research and analytical applications. Dehydrodiisoeugenol is isolated from Myristica fragrans Houtt, shows anti-inflammatory and anti-bacterial actions . Dehydrodiisoeugenol inhibits LPS-stimulated NF-κB activation and cyclooxygenase (COX)-2 gene expression in murine macrophages .

HY-13982

JSH-23 Maximum Cited Publications 92 Publications Verification	NF-κB	Metabolic Disease Inflammation/Immunology Cancer
JSH-23 is an NF-κB inhibitor which inhibits NF-κB transcriptional activity with an IC₅₀ of 7.1 μM in lipopolysaccharide (LPS)-stimulated macrophages RAW 264.7. JSH-23 inhibits nuclear translocation of NF-κB p65 without affecting IκBα degradation .

HY-169057

BI1543673	IRAK Toll-like Receptor (TLR)	Inflammation/Immunology
BI1543673 is an interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor. BI1543673 can reduce the inflammatory response stimulated by TLR4 and TLR7/8 in human lung tissue. BI1543673 can decrease inflammatory signaling in a mouse model of lung inflammation induced by LPS .

Cat. No.	Product Name	Category	Target	Chemical Structure