Search Result

Pathways Recommended:	NF-κB

Results for "

NF-κB p65

" in MedChemExpress (MCE) Product Catalog:

By Targets:	NF-κB (45) Akt (1) Amyloid-β (1) Apoptosis (10) Autophagy (4) Bacterial (3) c-Myc (1) Caspase (2) COX (12) Endogenous Metabolite (8) ERK (3) Ferroptosis (3) GLUT (2) HDAC (2) HIV (2) HSV (2) IAP (1) IGF-1R (2) IKK (4) Influenza Virus (3) Interleukin Related (4) IRAK (2) Isotope-Labeled Compounds (1) Keap1-Nrf2 (3) MEK (1) Microtubule/Tubulin (1) Mitophagy (2) MMP (1) Na+/K+ ATPase (3) NO Synthase (4) NOD-like Receptor (NLR) (3) p38 MAPK (2) Parasite (3) PKC (1) PPAR (2) PROTACs (2) Reactive Oxygen Species (2) SARS-CoV (2) Sirtuin (1) STING (1) TGF-beta/Smad (1) TNF Receptor (5) Toll-like Receptor (TLR) (1)
By Research Areas:	Cancer (32) Cardiovascular Disease (5) Endocrinology (2) Infection (7) Inflammation/Immunology (47) Metabolic Disease (7) Neurological Disease (4)

By Targets:

NF-κB (45)

Akt (1)

Amyloid-β (1)

Apoptosis (10)

Autophagy (4)

Bacterial (3)

c-Myc (1)

Caspase (2)

COX (12)

Endogenous Metabolite (8)

ERK (3)

Ferroptosis (3)

GLUT (2)

HDAC (2)

HIV (2)

HSV (2)

IAP (1)

IGF-1R (2)

IKK (4)

Influenza Virus (3)

Interleukin Related (4)

IRAK (2)

Isotope-Labeled Compounds (1)

Keap1-Nrf2 (3)

MEK (1)

Microtubule/Tubulin (1)

Mitophagy (2)

MMP (1)

Na+/K+ ATPase (3)

NO Synthase (4)

NOD-like Receptor (NLR) (3)

p38 MAPK (2)

Parasite (3)

PKC (1)

PPAR (2)

PROTACs (2)

Reactive Oxygen Species (2)

SARS-CoV (2)

Sirtuin (1)

STING (1)

TGF-beta/Smad (1)

TNF Receptor (5)

Toll-like Receptor (TLR) (1)

By Research Areas:

Cancer (32)

Cardiovascular Disease (5)

Endocrinology (2)

Infection (7)

Inflammation/Immunology (47)

Metabolic Disease (7)

Neurological Disease (4)

Inhibitors & Agonists

Screening Libraries

Peptides

Natural
Products

Isotope-Labeled Compounds

Antibodies

Targets Recommended: NF-κB

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N0629

Maslinic acid 5+ Cited Publications Crategolic acid; 2α-Hydroxyoleanolic acid	NF-κB Bacterial HIV Endogenous Metabolite	Inflammation/Immunology Cancer
Maslinic acid can inhibit the DNA-binding activity of NF-κB p65 and abolish the phosphorylation of IκB-α, which is required for p65 activation.

HY-N0694

Schisantherin A 1 Publications Verification Gomisin-C; Schizantherin-A; Wuweizi ester-A	NF-κB	Inflammation/Immunology
Schisantherin A is a dibenzocyclooctadiene lignan. Schisantherin A inhibits *p65-NF-κB* translocation into the nucleus by IκBα degradation.

HY-119970

Helenalin 5 Publications Verification	NF-κB	Inflammation/Immunology Cancer
Helenalin is an anti-inflammatory sesquiterpene lactone. Helenalin selectively inhibits transcription factor *NF-κB* by directly targeting p65. Helenalin has alkylating activity, targets the cysteine sulfhydryl groups in the p65 subunit of NF-κB, thereby inhibits its DNA binding .

HY-P1832A

PTD-p65-P1 Peptide TFA 3 Publications Verification	NF-κB Apoptosis	Inflammation/Immunology Cancer
PTD-p65-P1 Peptide TFA is a potent, selective nuclear transcription factor *NF-κB* inhibitor and derives from the p65 subunit of NF-κB amino acid residues 271-282, which selectively inhibits NF-κB activation induced by various inflammatory stimulation, down-regulate NF-κB-mediated gene expression and up-regulate apoptosis .

HY-N1956

Rubiadin-1-methyl ether	NF-κB	Metabolic Disease
Rubiadin-1-methyl ether is a natural anthraquinone isolated from Morinda officinalis How, and inhibits osteoclastic bone resorption via inhibition on the phosphorylation of NF-κB p65 and the degradation of IκBα as well as decrease in the nuclear translocation of p65 .

HY-N1987

Cucurbitacin IIb 1 Publications Verification	Apoptosis	Inflammation/Immunology
Cucurbitacin IIb is an active component isolated from Hemsleya amabilis, induces apoptosis with anti-inflammatory activity. Cucurbitacin IIb inhibits phosphorylation of STAT3, JNK and Erk1/2, enhances the phosphorylation of IκB and NF-κB (p65), blocks nuclear translocation of NF-κB (p65) and decreases mRNA levels of IκBα and TNF-α .

HY-N0629R

Maslinic acid (Standard)	NF-κB Bacterial HIV Endogenous Metabolite	Inflammation/Immunology Cancer
Maslinic acid (Standard) is the analytical standard of Maslinic acid. This product is intended for research and analytical applications. Maslinic acid can inhibit the DNA-binding activity of NF-κB p65 and abolish the phosphorylation of IκB-α, which is required for p65 activation.

HY-P1832

PTD-p65-P1 Peptide	NF-κB Apoptosis	Inflammation/Immunology Cancer
PTD-p65-P1 Peptide is a potent, selective nuclear transcription factor *NF-κB* inhibitor and derives from the p65 subunit of NF-κB amino acid residues 271-282, which selectively inhibits NF-κB activation induced by various inflammatory stimulation, down-regulate NF-κB-mediated gene expression and up-regulate apoptosis .

HY-139833

Anti-inflammatory agent 6	NF-κB IKK	Inflammation/Immunology
Anti-inflammatory agent 6 blocks the phosphorylation of I kappa b kinase α/β (IKKα/β), IκBα, and nuclear factor kB p65 (NF-κB p65) which is a key controller of inflammation, thereby showing anti-inflammatory potential.

HY-N0694R

Schisantherin A (Standard)	NF-κB	Inflammation/Immunology
Schisantherin A (Standard) is the analytical standard of Schisantherin A. This product is intended for research and analytical applications. Schisantherin A is a dibenzocyclooctadiene lignan. Schisantherin A inhibits p65-NF-κB translocation into the nucleus by IκBα degradation.

HY-162092

Multi-target Pt	NF-κB IKK	Cancer
Multi-target Pt (IV), an antitumor agent, suppresses the IKKβ phosphorylation, IκBα phosphorylation and NF-κB p65 phosphorylation and nuclear translocation, leading to blocked the NF-kB signal pathway .

HY-10496

SC75741 10+ Cited Publications	NF-κB Influenza Virus	Infection Cancer
SC75741 is a broad and efficient *NF-κB* inhibitor with an IC₅₀ of 200 nM for *p65* . SC75741 blocks influenza viruses (IV) replication. SC75741 impairs DNA binding of the *NF-κB* subunit p65, resulting in reduced expression of cytokines, chemokines, and pro-apoptotic factors. SC75741 subsequently inhibits caspase activation and blocks caspase-mediated nuclear export of viral ribonucleoproteins .

HY-N0191

Andrographolide 15+ Cited Publications Andrographis	NF-κB SARS-CoV Influenza Virus Autophagy Parasite	Infection Inflammation/Immunology Cancer
Andrographolide is a *NF-κB* inhibitor, which inhibits NF-κB activation through covalent modification of a cysteine residue on p50 in endothelial cells without affecting IκBα degradation or p50/p65 nuclear translocation. Andrographolide has antiviral effects.

HY-13982

JSH-23 Maximum Cited Publications 91 Publications Verification	NF-κB	Metabolic Disease Inflammation/Immunology Cancer
JSH-23 is an *NF-κB* inhibitor which inhibits NF-κB transcriptional activity with an IC₅₀ of 7.1 μM in lipopolysaccharide (LPS)-stimulated macrophages RAW 264.7. JSH-23 inhibits nuclear translocation of NF-κB p65 without affecting IκBα degradation .

HY-N0191R

Andrographolide (Standard)	NF-κB SARS-CoV Influenza Virus Autophagy Parasite	Infection Inflammation/Immunology Cancer
Andrographolide (Standard) is the analytical standard of Andrographolide. This product is intended for research and analytical applications. Andrographolide is a NF-κB inhibitor, which inhibits NF-κB activation through covalent modification of a cysteine residue on p50 in endothelial cells without affecting IκBα degradation or p50/p65 nuclear translocation. Andrographolide has antiviral effects.

HY-N4187

Licochalcone D 2 Publications Verification	NF-κB Apoptosis Reactive Oxygen Species	Metabolic Disease Inflammation/Immunology Cancer
Licochalcone D, a flavonoid compound mainly existing in the root of Glycyrrhiza uralensis, is a potent and orally active inhibitor of NF-kappaB (NF-κB) p65. Licochalcone D possesses antioxidant, anti-inflammatory, anti-cancer properties .

HY-N0290

Mangiferin 5+ Cited Publications	NF-κB Keap1-Nrf2 Apoptosis	Cancer
Mangiferin is a Nrf2 activator. Mangiferin suppresses nuclear translocation of the *NF-κB* subunits *p65* and p50. Mangiferin exhibits antioxidant, antidiabetic, antihyperuricemic, antiviral, anticancer and antiinflammatory activities .

HY-120515

7-Oxostaurosporine	PKC	Cancer
7-Oxostaurosporine is a potent protein kinase C (PKC) inhibitor that effectively inhibits tumor growth by inducing apoptosis and inhibiting the nuclear factor (NF)-κB/p-p65 pathway .

HY-162170

Anti-inflammatory agent 72	NF-κB Keap1-Nrf2 p38 MAPK	Inflammation/Immunology
Anti-inflammatory agent 72 (compound 5) is a novel resveratrol derivative hybrid with benzoylhydrazine. Anti-inflammatory agent 72 shows anti-inflammatory and antioxidant activities by activating Nrf2 and inhibiting *NF-κB p65/iNOS and MAPKs* signaling pathways .

HY-N0001

(-)-Epicatechin 3 Publications Verification (-)-Epicatechol; Epicatechin; epi-Catechin	COX Ferroptosis Endogenous Metabolite	Inflammation/Immunology Cancer
(-)-Epicatechin inhibits cyclooxygenase-1 (COX-1) with an IC₅₀ of 3.2 μM. (-)-Epicatechin inhibits the IL-1β-induced expression of iNOS by blocking the nuclear localization of the p65 subunit of NF-κB.

HY-N12604

Penicisteck acid F	NF-κB	Others
Penicisteck acid F (Compound 2) is a Marine derived tanzanic acid derivative that is a *NF-κB* inhibitor. Penicisteck acid F inhibits osteoclast expression by decreasing RANKL-induced IκBα degradation, NF-κB p65 nuclear translocation, NFATc1 activation and nuclear translocation, and related mRNA expression. Penicisteck acid F can be used in osteoporosis research .

HY-161329

NLRP3-IN-32	NOD-like Receptor (NLR) Reactive Oxygen Species NF-κB IKK	Inflammation/Immunology
NLRP3-IN-32 (compound 7a), a 3, 4-dihydronaphthalene-1(2H)-one derivative, is a potential NLRP3 inflammatory vesicles inhibitor. NLRP3-IN-32 can block the assembly and activation of NLRP3 inflammasome by down-regulating the expression of NLPR3 and apoptosis-associated speck-like protein containing a CARD (ASC), and inhibiting the production of reactive oxygen species (ROS) and other inflammatory mediators. NLRP3-IN-32 inhibits the phosphorylation of IκBα and NF-κB/p65 and the nuclear translocation of p65, thereby inhibiting *NF-κB* signaling .

HY-N0039

Ginsenoside Rb1 5 Publications Verification Gypenoside III	Na+/K+ ATPase IRAK NF-κB Autophagy Mitophagy HSV	Inflammation/Immunology Cancer
Ginsenoside Rb1, a main constituent of the root of Panax ginseng, inhibits Na ⁺, K ⁺-ATPase activity with an IC₅₀ of 6.3±1.0 μM. Ginsenoside also inhibits IRAK-1 activation and phosphorylation of NF-κB p65 .

HY-114981

SRTCX1002	Sirtuin	Inflammation/Immunology
SRTCX1002 is a potent activator of SIRT1 (STAC), suppresses inflammatory responses through promotion of p65 deacetylation and inhibition of NF-κB Activity. SRTCX1002 suppresses stimuli-induced NF-κB transcriptional activation and LPS-induced TNFα secretion with IC₅₀s of 0.71 and 7.58 µM, respectively .

HY-N0222

Avicularin 3 Publications Verification	COX NF-κB PPAR ERK GLUT Apoptosis	Infection Neurological Disease Inflammation/Immunology Cancer
Avicularin is an orally active flavonoid. Avicularin inhibits NF-κB (p65), COX-2 and PPAR-γ activities. Avicularin has anti-inflammatory, anti-infectious anti-allergic, anti-oxidant, hepatoprotective, and anti-tumor activities .

HY-152089

SB26019	Microtubule/Tubulin	Neurological Disease Inflammation/Immunology
SB26019 is a potent anti-neuroinflammatory agent. SB26019 regulates NF-κB activation by inducing monomeric α-tubulin formation. SB26019-induced α-tubulin monomer inhibits p65 translocation .

HY-121471

Chrysoeriol 1 Publications Verification	Endogenous Metabolite	Metabolic Disease
Chrysoeriol is a kind of natural yellow ash, which can be used for heating plants Coronopus didymus. Chrysoeriol suppresses the JAK2/STAT3, IκB/p65, and NF-κB pathways, and has strong anti-inflammatory activity .

HY-162316

NF-κB-IN-15	NF-κB	Inflammation/Immunology
NF-κB-IN-15 (compound 14r) is a potent *NF-κB* inhibitor. NF-κB-IN-15 decreases the NO levels and inhibits the release of IL-6, TNF-α, and IL-1β in LPS (HY-D1056) -induced cells. NF-κB-IN-15 inhibits LPS-induced phosphorylation of p65 and degradation of IκBα. NF-κB-IN-15 shows anti-inflammatory activity has the potential for the research of acute lung injury (ALI) .

HY-100581

CORM-3 1 Publications Verification	NF-κB NOD-like Receptor (NLR)	Inflammation/Immunology
CORM-3, a carbon monoxide-releasing molecule, attenuates NF-κB p65 nuclear translocation, reduces ROS generation and enhances intracellular glutathione and superoxide dismutase levels. CORM-3 reduces NLRP3 inflammasome activation .

HY-N9149

Cryptanoside A	Na+/K+ ATPase Akt NF-κB	Cardiovascular Disease Inflammation/Immunology Cancer
Cryptanoside A, a cardiac glycoside epoxide, can be isolated from the stems of Cryptolepis dubia. Cryptanoside A has potent cytotoxicity against cancer cells. Cryptanoside A also inhibits Na+/K+-ATPase activity. Cryptanoside A increases the expression of Akt and the p65 subunit of NF-κB .

HY-155998

NF-κB-IN-11	NF-κB	Inflammation/Immunology
NF-κB-IN-11 (Compound 3i) is a *NF-κB* inhibitor. NF-κB-IN-11 inhibits TNF-α induced activation of NF-κB pathway, and inhibits nuclear translocation of NF-κB. NF-κB-IN-11 down-regulates the expression levels of phosphor-IKK, IκBα, and NF-κB p65. NF-κB-IN-11 has anti-inflammatory activity, and alleviates dextran sulfate sodium-induced colitis in mice. NF-κB-IN-11 (p.o.) shows a MTD more than 1852 mg/kg in mice acute toxicity assay .

HY-N3552

Catalposide	NF-κB	Inflammation/Immunology
Catalposide, an iridoid glycoside that could be isolated from Catalpa ovate G. Don (Bignoniaceae), inhibits TNF-α, IL-1β, and IL-6 productions and NF-κB (p65) activation in lipopolysaccharide-activated RAW 264.7 macrophages .

HY-149513

EP12	c-Myc Apoptosis	Cancer
EP12 is a c-Myc inhibitor. EP12 is a c-Myc G4 stabilizer. EP12 induces apoptosis and DNA damage in multiple myeloma cells. EP12 disrupts the nuclear translocation of P65/P50 by interfering with the NF-κB signaling pathway. EP12 inhibits multiple myeloma growth .

HY-111172

Inotilone	MMP NF-κB	Cancer
Inotilone is an inhibitor of matrix metalloproteinase MMP-2 and MMP-9, to against metastatic in lung cancer cells. Inotilone enhances the activity of the antioxidant enzymes to support its anti-metastatic activity. Inotilone also inhibits IκBα phosphorylation and NFκB p65 nuclear translocation, involving in FAK, PI3K/AKT, MAPKs and NFκB pathways .

HY-N0290R

Mangiferin (Standard)	NF-κB Keap1-Nrf2 Apoptosis	Cancer
Mangiferin (Standard) is the analytical standard of Mangiferin. This product is intended for research and analytical applications. Mangiferin is a Nrf2 activator. Mangiferin suppresses nuclear translocation of the NF-κB subunits p65 and p50. Mangiferin exhibits antioxidant, antidiabetic, antihyperuricemic, antiviral, anticancer and antiinflammatory activities .

HY-P10462

SAP15 Synthetic anti-iNFlammatory peptide 15	HDAC NF-κB	Inflammation/Immunology
SAP15 (Synthetic anti-inflammatory peptide 15) is a synthetic anti-inflammatory peptide consisting of 15 amino acids designed from human beta-defensin 3. SAP15 has the ability to penetrate cells and is able to induce downregulation of intracellular inflammation. SAP15 inhibits inflammation by inhibiting the phosphorylation of HDAC5 and thereby reducing the phosphorylation of NF-κB p65. In LPS-induced macrophages, SAP15 inhibits HDAC5 and NF-κB p65 phosphorylation. In addition, SAP15 treatment increased the expression of aggrecan and type II collagen and decreased the expression of osteocalcin in LPS-induced chondrocytes. SAP15 can be used in the study of inflammation regulation and anti-inflammatory therapy of biomaterials .

HY-159516

Sabialimon P	NO Synthase TNF Receptor NF-κB COX Interleukin Related	Inflammation/Immunology
Sabialimon P (compound 16) is a NO release inhibitor (IC₅₀=18.12 μM) with anti-inflammatory activity. Sabialimon P significantly reduces the secretion of TNF-α, iNOS, IL-6 and *NF-κB* and inhibits the expression of COX-2 and *NF-κB/p65* in RAW264.7 cells induced by LPS (HY-D1056) .

HY-168070

COX-2-IN-48	COX NF-κB NO Synthase	Inflammation/Immunology
COX-2-IN-48 (5-25), a COX-2 inhibitor with an IC₅₀ of 51.7 nM for human COX-2, exerts anti-inflammatory and analgesic effects in various rodent models by inhibiting *NF-κB* pathway. COX-2-IN-48 (5-25) inhibits the degradation of IκB, the phosphorylation and nuclear translocation of NF-κB p65, and the expression of COX-2 and iNOS .

HY-N0722

Neochlorogenic acid 1 Publications Verification trans-5-O-Caffeoylquinic acid	NF-κB Interleukin Related TNF Receptor COX	Inflammation/Immunology Cancer
Neochlorogenic acid is a natural polyphenolic compound found in dried fruits and other plants. Neochlorogenic acid inhibits the production of TNF-α and IL-1β. Neochlorogenic acid suppresses iNOS and COX-2 protein expression. Neochlorogenic acid also inhibits phosphorylated NF-κB p65 and p38 MAPK activation.

HY-125171

IAXO-102 4 Publications Verification	Toll-like Receptor (TLR)	Inflammation/Immunology
IAXO-102 is a TLR4 antagonist which negatively regulates TLR4 signalling. IAXO-102 inhibits MAPK and p65 NF-κB phosphorylation and expression of TLR4 dependent proinflammatory protein. IAXO-102 also prevents experimental abdominal aortic aneurysm development .

HY-149331

TNF-α-IN-11	TNF Receptor Caspase NF-κB	Inflammation/Immunology
TNF-α-IN-11 (Compound 10) is a TNF-α inhibitor with a K_D value of 12.06 μM. TNF-α-IN-11 binds to TNF-α and blocks the activation of TNF-α-trigged caspase and *NF-κB* signaling pathway. TNF-α-IN-11 inhibits the phosphorylation of IκBα, as well as the nuclear translocation of NF κB p65. TNF-α-IN-11 can be used for research of TNF-α-mediated autoimmune diseases .

HY-N0001R

(-)-Epicatechin (Standard) (-)-Epicatechol(Standard); Epicatechin(Standard); epi-Catechin (Standard)	COX Ferroptosis Endogenous Metabolite	Inflammation/Immunology Cancer
(-)-Epicatechin (Standard) is the analytical standard of (-)-Epicatechin. This product is intended for research and analytical applications. (-)-Epicatechin inhibits cyclooxygenase-1 (COX-1) with an IC₅₀ of 3.2 μM. (-)-Epicatechin inhibits the IL-1β-induced expression of iNOS by blocking the nuclear localization of the p65 subunit of NF-κB.

HY-121471R

Chrysoeriol (Standard)	Endogenous Metabolite	Metabolic Disease
Chrysoeriol (Standard) is the analytical standard of Chrysoeriol. This product is intended for research and analytical applications. Chrysoeriol is a kind of natural yellow ash, which can be used for heating plants Coronopus didymus. Chrysoeriol suppresses the JAK2/STAT3, IκB/p65, and NF-κB pathways, and has strong anti-inflammatory activity .

HY-N6009

8-Deoxygartanin	Parasite NF-κB	Infection
8-Deoxygartanin, a prenylated xanthones from G. mangostana, is a selective inhibitor of butyrylcholinesterase (BChE) . 8-Deoxygartanin exhibits antiplasmodial activity with an IC₅₀ of 11.8 μM for the W2 strain of Plasmodium falciparum . 8-Deoxygartanin inhibits NF-κB (p65) activation with an IC₅₀ of 11.3 μM .

HY-N0222R

Avicularin (Standard)	COX NF-κB PPAR ERK GLUT Apoptosis	Infection Neurological Disease Inflammation/Immunology Cancer
Avicularin (Standard) is the analytical standard of Avicularin. This product is intended for research and analytical applications. Avicularin is an orally active flavonoid. Avicularin inhibits NF-κB (p65), COX-2 and PPAR-γ activities. Avicularin has anti-inflammatory, anti-infectious anti-allergic, anti-oxidant, hepatoprotective, and anti-tumor activities .

HY-N0001S

(±)-Epicatechin-13C3	Isotope-Labeled Compounds COX Endogenous Metabolite Ferroptosis	Inflammation/Immunology Cancer
(±)-Epicatechin- ¹³C₃ is the ¹³C labeled (±)-Epicatechin. (-)-Epicatechin (HY-N0001) inhibits cyclooxygenase-1 (COX-1) with an IC50 of 3.2 μM. (-)-Epicatechin inhibits the IL-1β-induced expression of iNOS by blocking the nuclear localization of the p65 subunit of NF-κB[1].

HY-N0039R

Ginsenoside Rb1 (Standard) Gypenoside III (Standard)	Na+/K+ ATPase IRAK NF-κB Autophagy Mitophagy HSV	Inflammation/Immunology Cancer
Ginsenoside Rb1 (Standard) is the analytical standard of Ginsenoside Rb1. This product is intended for research and analytical applications. Ginsenoside Rb1, a main constituent of the root of Panax ginseng, inhibits Na ⁺, K ⁺-ATPase activity with an IC₅₀ of 6.3±1.0 μM. Ginsenoside also inhibits IRAK-1 activation and phosphorylation of NF-κB p65 .

HY-149724

Anti-inflammatory agent 65	STING NO Synthase	Inflammation/Immunology
Anti-inflammatory agent 65 (compound 29) is a Hederagonic acid derivative with potent anti-inflammatory activity. Anti-inflammatory agent 65 inhibits nitric oxide (NO) release. Anti-inflammatory agent 65 inhibits the nuclear translocation of IRF3 and p65, and disrupts the STING/IRF3/NF-κB signaling pathway, thereby attenuating the inflammatory response .

HY-123984

LTβR-IN-1	NF-κB	Metabolic Disease
LTβR-IN-1 is a potent, selective lymphotoxin β receptor (LTβR) inhibitor. LTβR-IN-1 also selectively inhibits the nuclear translocation of p52 depended on TNF12A, instead of the nuclear translocation of p65 mediated by TNF-α receptor. LTβR-IN-1 regulates the NF-kB signaling pathway IN a ligand-independent manner .

HY-N0722R

Neochlorogenic acid (Standard)	NF-κB Interleukin Related TNF Receptor COX	Inflammation/Immunology Cancer
Neochlorogenic acid (Standard) is the analytical standard of Neochlorogenic acid. This product is intended for research and analytical applications. Neochlorogenic acid is a natural polyphenolic compound found in dried fruits and other plants. Neochlorogenic acid inhibits the production of TNF-α and IL-1β. Neochlorogenic acid suppresses iNOS and COX-2 protein expression. Neochlorogenic acid also inhibits phosphorylated NF-κB p65 and p38 MAPK activation.

Cat. No.	Product Name

HY-L014

NF-κB Signaling Compound Library

876 compounds

Nuclear factor-κB (NF-κB)/Rel proteins include NF-κB2 p52/p100, NF-κB1 p50/p105, c-Rel, RelA/p65, and RelB. These proteins function as dimeric transcription factors that regulate the expression of genes and influence a broad range of biological processes including innate and adaptive immunity, inflammation, stress responses, B-cell development, and lymphoid organogenesis. NF-κB plays a key role in regulating the immune response to infection. In addition, activation of the NF-κB pathway is involved in the pathogenesis of chronic inflammatory diseases, such as asthma, rheumatoid arthritis, and inflammatory bowel disease. Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development.

MCE owns a unique collection of 876 small molecule compounds that can be used in the research of NF-κB signaling pathway or high throughput screening (HTS) related drug discovery.

Cat. No.	Product Name	Target	Research Area

HY-P1832A

PTD-p65-P1 Peptide TFA 3 Publications Verification	NF-κB Apoptosis	Inflammation/Immunology Cancer
PTD-p65-P1 Peptide TFA is a potent, selective nuclear transcription factor *NF-κB* inhibitor and derives from the p65 subunit of NF-κB amino acid residues 271-282, which selectively inhibits NF-κB activation induced by various inflammatory stimulation, down-regulate NF-κB-mediated gene expression and up-regulate apoptosis .

HY-P1832

PTD-p65-P1 Peptide	NF-κB Apoptosis	Inflammation/Immunology Cancer
PTD-p65-P1 Peptide is a potent, selective nuclear transcription factor *NF-κB* inhibitor and derives from the p65 subunit of NF-κB amino acid residues 271-282, which selectively inhibits NF-κB activation induced by various inflammatory stimulation, down-regulate NF-κB-mediated gene expression and up-regulate apoptosis .

HY-P10462

SAP15 Synthetic anti-iNFlammatory peptide 15	HDAC NF-κB	Inflammation/Immunology
SAP15 (Synthetic anti-inflammatory peptide 15) is a synthetic anti-inflammatory peptide consisting of 15 amino acids designed from human beta-defensin 3. SAP15 has the ability to penetrate cells and is able to induce downregulation of intracellular inflammation. SAP15 inhibits inflammation by inhibiting the phosphorylation of HDAC5 and thereby reducing the phosphorylation of NF-κB p65. In LPS-induced macrophages, SAP15 inhibits HDAC5 and NF-κB p65 phosphorylation. In addition, SAP15 treatment increased the expression of aggrecan and type II collagen and decreased the expression of osteocalcin in LPS-induced chondrocytes. SAP15 can be used in the study of inflammation regulation and anti-inflammatory therapy of biomaterials .

Cat. No.	Product Name	Chemical Structure

HY-N0001S

(±)-Epicatechin-13C3
(±)-Epicatechin- ¹³C₃ is the ¹³C labeled (±)-Epicatechin. (-)-Epicatechin (HY-N0001) inhibits cyclooxygenase-1 (COX-1) with an IC50 of 3.2 μM. (-)-Epicatechin inhibits the IL-1β-induced expression of iNOS by blocking the nuclear localization of the p65 subunit of NF-κB[1].

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P80245

	*NF-κB p65* Antibody** 2 Publications Verification	WB, ICC/IF, IHC-P, IP, FC	Human, Mouse
	NF-κB p65 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 65 kDa, targeting to NF-κB p65. It can be used for WB,ICC/IF,IHC-P,IP,FC assays with tag free, in the background of Human, Mouse.

HY-P80470

	*Phospho-NF-κB p65* (Ser529) Antibody**	WB, IP, FC, IHC-P	Human
	Phospho-NF-κB p65 (Ser529) Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 60 kDa, targeting to Phospho-NF-κB p65(S529). It can be used for WB,IP,FC,IHC-P assays with tag free, in the background of Human.

HY-P81238

	*Phospho-NF-κB p65* (Ser536) Antibody** NF-kB p65 (phospho S536); p-NF-κB p65(Phospho-Ser536); RELA(phospho S536); NF kB p65; NF-kB p65; NFKBp65; NF-κBp65; p65 NF kappaB; p65 NFkB; NFKBp65; RELA; Transcription Factor p65; v rel avian reticuloendotheliosis viral oncogene homolog A (nuclear factor of kappa light polypeptide gene enhancer in B cells 3 (p65)); V Rel Avian Reticuloendotheliosis Viral Oncogene Homolog A; v rel reticuloendotheliosis viral oncogene homolog A (avian); v-rel reticuloendotheliosis viral oncogene homolog A; p65NFKB; Avian reticuloendotheliosis viral (v rel) oncogene homolog A; MGC131774; NFKB 3; NFKB3; Nuclear Factor NF Kappa B p65 Subunit; Nuclear factor of kappa light polypeptide gene enhancer in B cells 3; Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B Cells; TF65_HUMAN. NFκB-p65; NFκB p65; NF κB-p65; NFκBp65	WB, IHC-P, FC	Human, Mouse, Rat
	Phospho-NF-κB p65 (Ser536) Antibody is a rabbit-derived non-conjugated IgG antibody, targeting Phospho-NF-κB p65 (Ser536), with a predicted molecular weight of 61 kDa. Phospho-NF-κB p65 (Ser536) Antibody can be used for WB, IHC-P, FC experiments in human, mouse, rat backgrounds.

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