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NeuropeptideY (18-36) (porcine) is a competitive neuropeptideY (NPY) cardiac receptor antagonist. NeuropeptideY (18-36) (porcine) inhibits the binding of I-NPY to cardiac ventricular membranes in a concentration-dependent manner with an IC50 value of 158 nM and an Ki value of 140 nM. NeuropeptideY (18-36) (porcine) can be used for the research of congestive heart failure .
[D-Trp34]-NeuropeptideY is a potent and selective neuropeptideY (NPY) Y5receptor agonist. [D-Trp34]-NeuropeptideY is a significantly less potent agonist at the NPY Y1,Y2,Y4, and y6receptors. [D-Trp34]-NeuropeptideY markedly increases food intake in rats .
NeuropeptideYY1 receptor antagonist 1 (compound 39), a fluorescent probe, is a potent antagonist of neuropeptideYY1receptor (Y1R), with a Ki of 0.19 nM .
NeuropeptideY (3-36) (porcine) is an agonist of neuropeptideY (NPY) receptor subtype Y2, and stimulates feeding in rats. NeuropeptideY (3-36) (porcine) is a highly Y2 selective ligand compared with nselective Y1/Y2 receptor ligand, NeuropeptideY 1-36 .
Y1R probe-1 (Compound 39) is a high-affinity fluorescence probe for the NeuropeptideYY1 Receptor. Y1R probe-1 has the potential for the research of cancer disease .
BIBO3304 (diTFA) is an orally effective and selective neuropeptideY (NPY) Y1receptor antagonist. BIBO3304 (diTFA) has a high affinity for both human and rat Y1 receptors, with IC50 values of 0.38 and 0.72 nM, respectively. BIBO3304 (diTFA) promotes bone-tendon healing through the Wnt/β-catenin signaling pathway .
NeuropeptideY (22-36), a 15 amino acid peptide, is a fragment of NeuropeptideY. NeuropeptideY (22-36) acts on Y2receptor and retains subnanomolar affinity for the Y2receptor .
[D-Trp34]-NeuropeptideY TFA is a potent and selective neuropeptideY (NPY) Y5receptor agonist. [D-Trp34]-NeuropeptideY TFA is a significantly less potent agonist at the NPY Y1,Y2,Y4, and y6receptors. [D-Trp34]-NeuropeptideY TFA markedly increases food intake in rats .
GR231118, an analogue of the C-terminus of neuropeptideY, is a potent , competitive and relative seletive antagonist at human neuropeptideYYreceptor with a pKi of 10.4. GR231118 a potent agonist at the human neuropeptideYY4 receptor (pEC50=8.6; pKi=9.6) and a weak agonist at the human and rat neuropeptide YY2 and Y5 receptors. GR231118 also has high affinity for the mouse neuropeptideYY6 receptor (pKi= 8.8) .
NeuropeptideY (2-36) (porcine) is a porcine-derived neuropeptide with 97.14% homology to rat/human origin. NeuropeptideY (2-36) (porcine) is also a rat neuropeptidereceptor agonist, with EC50 values of 1.2, 1.6 and 3.4 nM for receptor of Y5, Y2 and Y1 respectively. NeuropeptideY (2-36) (porcine) can be used in studies related to obesity and eating disorders .
[Leu31,Pro34]-NeuropeptideY(human,rat) is a specific neuropeptideYY1receptor agonist. [Leu31,Pro34]-NeuropeptideY(human,rat) slao activates Y4,Y5. [Leu31,Pro34]-NeuropeptideY(human,rat) can increase blood pressure in anesthetized rats and increases food intake .
[Leu31,Pro34]-NeuropeptideY(human,rat) TFA is a specific neuropeptideYY1receptor agonist. [Leu31,Pro34]-NeuropeptideY(human,rat) TFA slao activates Y4,Y5. [Leu31,Pro34]-NeuropeptideY(human,rat) TFA can increase blood pressure in anesthetized rats and increases food intake .
GR231118 TFA, an analogue of the C-terminus of neuropeptideY, is a potent , competitive and relative seletive antagonist at human neuropeptide YY receptor with a pKi of 10.4. GR231118 a potent agonist at the human neuropeptide YY4 receptor (pEC50=8.6; pKi=9.6) and a weak agonist at the human and rat neuropeptideYY2 and Y5 receptors. GR231118 also has high affinity for the mouse neuropeptide YY6 receptor (pKi= 8.8) .
NeuropeptideY (3-36) (human, rat), a neuropeptideY (NPY) metabolite formed from dipeptidyl peptidase-4 (DPP4), is a selective Y2 receptor agonist. NeuropeptideY (3-36) (human, rat) is a NPY metabolite formed from dipeptidyl peptidase-4 (DPP4). NeuropeptideY (3-36) (human, rat) decreases release of norepinephrine via the Y2 receptor .
BMS-193885 (L-Lactic acid) is a potent, selective, and brain-penetrant neuropeptideY1 receptor antagonist. BMS-193885 has a Ki value of 3.3 nM for the neuropeptideY1 receptor, competitively acts on the neuropeptideY binding site, and can reduce food intake and body weight through central Y1 inhibition .
[D-Arg25]-NeuropeptideY (human) ([D-Arg25] NPY) is a Y1receptor selective agonist. NeuropeptideY (human) is involved in Alzheimer's disease (AD) and protects rat cortical neurons against β-Amyloid toxicity .
CGP71683 hydrochloride is a competitive neuropeptideY5 receptor antagonist with a Ki of 1.3 nM, and shows no obvious activity at Y1 receptor (Ki, >4000 nM) and Y2 receptor (Ki, 200 nM) in cell membranes.
BWX 46 (((Cys31, Nva 34)-NeuropeptideY (27-36))2) is a selective Y5receptor agonist with an IC50 value of 0.85 nM. BWX 46 can inhibit the synthesis of cAMP in Y5 cells .
S 25585 is a potent and selective neuropeptideY (NPY) Y5 receptor antagonist. S 25585 reduces food intake but not through blockade of the NPY Y5 receptor .
BIBP3226 is a potent and selective neuropeptideYY1 (NPY Y1) and neuropeptide FF (NPFF) receptor antagonist, with Kis of 1.1, 79, and 108 nM for rNPY Y1, hNPFF2, and rNPFF, respectively. BIBP3226 displays anxiogenic-like effect .
Y1 receptor antagonist 1 formic (H 409-22 isomer formic) is the formic salt form of Y1 receptor antagonist 1 (HY-101704). Y1 receptor antagonist 1 formic is a neuropeptideY1 receptor antagonist.
BIBP3226 TFA is a potent and selective neuropeptideYY1 (NPY Y1) and neuropeptide FF (NPFF) receptor antagonist, with Kis of 1.1, 79, and 108 nM for rNPY Y1, hNPFF2, and rNPFF, respectively. BIBP3226 TFA displays anxiogenic-like effect .
BIBO3304 is a potent, orally active, and selective neuropeptideY (NPY) Y1 receptor antagonist, with subnanomolar affinity for both the human and the rat Y1 receptor (IC50=0.38 and 0.72 nM, respectively) .
JNJ-5207787 is a nonpeptidic, selective and penetrate the blood-brain barrier neuropeptideYY2receptor(Y2) antagonist. JNJ-5207787 inhibits the binding of peptide YY (PYY) with pIC50s of 7.0 and 7.1 for human Y2receptor and rat Y2receptor, respectively. JNJ-5207787 is >100-fold selective versus human Y1,Y4, and Y5receptors .
BIIE-0246 dihydrochloride (AR-H 053591 dihydrochloride) is a potent and highly selective non-peptideneuropeptideY (NPY) Y2receptor antagonist, with an IC50 value of 15 nM .
Neuropeptide AF (cattle), an amidated octadecapeptide, is RFamide neuropeptide. Neuropeptide AF (cattle) acts as a ligand of Mas-related gene receptor A4 (MrgprA4) (Mas-related G-protein-coupled Receptor (MRGPR)) (EC50 of ~60 nM) and MrgprC11 (EC50 of ~300 nM). Neuropeptide AF (cattle) also activate to the G protein-coupled receptorsNPFF1(NeuropeptideYReceptor) (EC50 of ~25-325 nM) and NPFF2 (EC50 of ~1-5 nM). Neuropeptide AF (cattle) shows anti-opiate and related pain modulation effects .
JNJ-31020028 is a selective and brain penetrant antagonist of neuropeptideYY2 receptor with pIC50 values of 8.07 and 8.22 for human and rat Y2 receptor, respectively. JNJ-31020028 can be used for the research of nervous disease .
SF-22 is a potent and brain-penetrant antagonist of neuropeptideYreceptor (Y2R), with the IC50 value of 750 nM. SF-22 plays an important role in neurological disease .
(R)-JNJ-31020028 is a high affinity, selective brain penetrant neuropeptideYY2 receptor antagonist, with pIC50 values of 8.07, 8.22 and 8.21 for human, rat, and mouse Y2 receptor, respectively. (R)-JNJ-31020028 shows >100-fold selective versus human Y1, Y4, and Y5 receptors. (R)-JNJ-31020028 has antidepressant like effects .
Peptide YY (PYY) (3-36), Human is an endogenous appetite suppressing peptide. Peptide YY (PYY) (3-36), Human, a neuropeptideY (NPY) Y2 receptor agonist, is a powerful inhibitor of intestinal secretion .
Lu AA33810 is a potent and selective antagonist of neuropeptideY5 receptor with a Ki of 1.5 nM for the human receptor. Lu AA33810 exhibts antianxiolytic-like and antidepressant-like effects .
BIBO3304 free base is a nonpeptide neuropeptideYY1receptor antagonist. BIBO3304 free base displays subnanomolar affinity for both the human and the rat Y1 receptor, with IC50 values of 0.38 nM and 0.72 nM, respectively. BIBO3304 free base significantly inhibits food intake induced by application of NPY or by fasting .
Peptide YY (PYY) is a gut hormone that regulates appetite and inhibits pancreatic secretion. Peptide YY (PYY) can mediate its effects through the NeuropeptideYreceptors.
L 152804 is an orally active and selective neuropeptideYY5 receptor (NPY5-R) antagonist, with a Ki of 26 nM for hY5. L 152804 causes weight loss in diet-induced obese mice by modulating food intake and energy expenditure .
FMS586 free base is a selective neuropeptideYY5 receptor antagonist with oral activity. FMS586 can completely block the significant increase in adrenocorticotropic hormone (ACTH) and cortisol caused by the Y(5) selective agonist hPP. FMS586 also reversed the significant upregulation of adrenocorticotropic hormone (CRF) and antidiuretic hormone (AVP) mRNA expression induced by central injection of hPP. FMS586 provides the first evidence that selective stimulation of Y(5) receptors triggers activation of the HPA axis .
BMS-193885 is a potent, selective, competitive, and brain penetrant neuropeptideY1receptor antagonist with a Ki of 3.3 nM, and has an IC50 of 5.9 nM for hY1, which displays > 100, > 160, > 160 and > 160-fold selectivity over α1, hY2, hY4 and hY5receptors, respectively .
2-Pyridylethylamine is a histamine-1 (H1R) receptor agonist. 2-Pyridylethylamine can reduce the joint injury induced by formalin in rats. 2-Pyridylethylamine can be used to study the spinal cord release of neuropeptide (NPY) .
[cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide is a potent and selective neuropeptideYY5receptor agonist with an IC50 of 0.24 nM for binding to the hY5receptor. [cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide induces a high amount of food intake .
[cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide is a potent and selective neuropeptideYY5receptor agonist with an IC50 of 0.24 nM for binding to the hY5receptor. [cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide induces a high amount of food intake .
BIIE-0246 (AR-H 053591) is a potent and selective NPY2R (neuropeptideYreceptor 2) antagonist with an IC50 value of 15 nM for rat [ 125I]PYY3-36. BIIE-0246 decreases the expression of p-AKT S473, P-p44/42 MAPK under the NPY-stimulated. BIIE-0246 reduces albuminuria in ADR nephropathy .
BIIE-0246 hydrochloride (AR-H 053591 hydrochloride) is a potent and selective NPY2R (neuropeptideYreceptor 2) antagonist with an IC50 value of 15 nM for rat [ 125I]PYY3-36. BIIE-0246 hydrochloride decreases the expression of p-AKT S473, P-p44/42 MAPK under the NPY-stimulated. BIIE-0246 hydrochloride reduces albuminuria in ADR nephropathy .
NeuropeptideYY1 receptor antagonist 1 (compound 39), a fluorescent probe, is a potent antagonist of neuropeptideYY1receptor (Y1R), with a Ki of 0.19 nM .
NeuropeptideY (18-36) (porcine) is a competitive neuropeptideY (NPY) cardiac receptor antagonist. NeuropeptideY (18-36) (porcine) inhibits the binding of I-NPY to cardiac ventricular membranes in a concentration-dependent manner with an IC50 value of 158 nM and an Ki value of 140 nM. NeuropeptideY (18-36) (porcine) can be used for the research of congestive heart failure .
[D-Trp34]-NeuropeptideY is a potent and selective neuropeptideY (NPY) Y5receptor agonist. [D-Trp34]-NeuropeptideY is a significantly less potent agonist at the NPY Y1,Y2,Y4, and y6receptors. [D-Trp34]-NeuropeptideY markedly increases food intake in rats .
NeuropeptideY (3-36) (porcine) is an agonist of neuropeptideY (NPY) receptor subtype Y2, and stimulates feeding in rats. NeuropeptideY (3-36) (porcine) is a highly Y2 selective ligand compared with nselective Y1/Y2 receptor ligand, NeuropeptideY 1-36 .
NeuropeptideY (22-36), a 15 amino acid peptide, is a fragment of NeuropeptideY. NeuropeptideY (22-36) acts on Y2receptor and retains subnanomolar affinity for the Y2receptor .
[D-Trp34]-NeuropeptideY TFA is a potent and selective neuropeptideY (NPY) Y5receptor agonist. [D-Trp34]-NeuropeptideY TFA is a significantly less potent agonist at the NPY Y1,Y2,Y4, and y6receptors. [D-Trp34]-NeuropeptideY TFA markedly increases food intake in rats .
GR231118, an analogue of the C-terminus of neuropeptideY, is a potent , competitive and relative seletive antagonist at human neuropeptideYYreceptor with a pKi of 10.4. GR231118 a potent agonist at the human neuropeptideYY4 receptor (pEC50=8.6; pKi=9.6) and a weak agonist at the human and rat neuropeptide YY2 and Y5 receptors. GR231118 also has high affinity for the mouse neuropeptideYY6 receptor (pKi= 8.8) .
NeuropeptideY (2-36) (porcine) is a porcine-derived neuropeptide with 97.14% homology to rat/human origin. NeuropeptideY (2-36) (porcine) is also a rat neuropeptidereceptor agonist, with EC50 values of 1.2, 1.6 and 3.4 nM for receptor of Y5, Y2 and Y1 respectively. NeuropeptideY (2-36) (porcine) can be used in studies related to obesity and eating disorders .
[Leu31,Pro34]-NeuropeptideY(human,rat) is a specific neuropeptideYY1receptor agonist. [Leu31,Pro34]-NeuropeptideY(human,rat) slao activates Y4,Y5. [Leu31,Pro34]-NeuropeptideY(human,rat) can increase blood pressure in anesthetized rats and increases food intake .
[Leu31,Pro34]-NeuropeptideY(human,rat) TFA is a specific neuropeptideYY1receptor agonist. [Leu31,Pro34]-NeuropeptideY(human,rat) TFA slao activates Y4,Y5. [Leu31,Pro34]-NeuropeptideY(human,rat) TFA can increase blood pressure in anesthetized rats and increases food intake .
GR231118 TFA, an analogue of the C-terminus of neuropeptideY, is a potent , competitive and relative seletive antagonist at human neuropeptide YY receptor with a pKi of 10.4. GR231118 a potent agonist at the human neuropeptide YY4 receptor (pEC50=8.6; pKi=9.6) and a weak agonist at the human and rat neuropeptideYY2 and Y5 receptors. GR231118 also has high affinity for the mouse neuropeptide YY6 receptor (pKi= 8.8) .
NeuropeptideY (3-36) (human, rat), a neuropeptideY (NPY) metabolite formed from dipeptidyl peptidase-4 (DPP4), is a selective Y2 receptor agonist. NeuropeptideY (3-36) (human, rat) is a NPY metabolite formed from dipeptidyl peptidase-4 (DPP4). NeuropeptideY (3-36) (human, rat) decreases release of norepinephrine via the Y2 receptor .
[D-Arg25]-NeuropeptideY (human) ([D-Arg25] NPY) is a Y1receptor selective agonist. NeuropeptideY (human) is involved in Alzheimer's disease (AD) and protects rat cortical neurons against β-Amyloid toxicity .
BWX 46 (((Cys31, Nva 34)-NeuropeptideY (27-36))2) is a selective Y5receptor agonist with an IC50 value of 0.85 nM. BWX 46 can inhibit the synthesis of cAMP in Y5 cells .
Neuropeptide AF (cattle), an amidated octadecapeptide, is RFamide neuropeptide. Neuropeptide AF (cattle) acts as a ligand of Mas-related gene receptor A4 (MrgprA4) (Mas-related G-protein-coupled Receptor (MRGPR)) (EC50 of ~60 nM) and MrgprC11 (EC50 of ~300 nM). Neuropeptide AF (cattle) also activate to the G protein-coupled receptorsNPFF1(NeuropeptideYReceptor) (EC50 of ~25-325 nM) and NPFF2 (EC50 of ~1-5 nM). Neuropeptide AF (cattle) shows anti-opiate and related pain modulation effects .
Peptide YY (PYY) (3-36), Human is an endogenous appetite suppressing peptide. Peptide YY (PYY) (3-36), Human, a neuropeptideY (NPY) Y2 receptor agonist, is a powerful inhibitor of intestinal secretion .
Peptide YY (PYY) is a gut hormone that regulates appetite and inhibits pancreatic secretion. Peptide YY (PYY) can mediate its effects through the NeuropeptideYreceptors.
[cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide is a potent and selective neuropeptideYY5receptor agonist with an IC50 of 0.24 nM for binding to the hY5receptor. [cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide induces a high amount of food intake .
[cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide is a potent and selective neuropeptideYY5receptor agonist with an IC50 of 0.24 nM for binding to the hY5receptor. [cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide induces a high amount of food intake .
NPY2R, the neuropeptide Y (NPY) and peptide YY (PYY) receptors, exhibit different affinities for pancreatic peptides. Preferences in descending order include PYY > NPY > PYY (3-36) > NPY (2-36) > [Ile-31, Gln-34] PP > [Leu-31, Pro-34] NPY > PP, [ Pro -34] PYY and NPY free acids. NPY2R Protein, Human (Cell-Free, His) is the recombinant human-derived NPY2R protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of NPY2R Protein, Human (Cell-Free, His) is 381 a.a., with molecular weight of 48.8 kDa.
The CXCR4 protein functions as a receptor for the CXC chemokine CXCL12/SDF-1, triggering an increase in intracellular calcium ions and activation of MAPK1/MAPK3. It is actively involved in AKT signaling, which is critical for regulating cell migration, especially in wound healing. CXCR4 Protein, Human (GST) is the recombinant human-derived CXCR4 protein, expressed by E. coli , with N-GST labeled tag. The total length of CXCR4 Protein, Human (GST) is 50 a.a., with molecular weight of ~32.6 kDa.
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