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Isoforms Recommended:	TRPV

Results for "

TRPV1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (1) Adrenergic Receptor (2) Akt (2) Apoptosis (10) Autophagy (6) Bacterial (3) Bcl-2 Family (2) Cannabinoid Receptor (8) Caspase (3) CGRP Receptor (2) Chloride Channel (1) Cholinesterase (ChE) (2) COX (1) Endogenous Metabolite (16) FAAH (2) Fungal (2) GPR55 (2) Histamine Receptor (1) HSV (2) Insulin Receptor (1) Interleukin Related (1) Isotope-Labeled Compounds (4) Lipoxygenase (1) Melatonin Receptor (1) MMP (1) Oxytocin Receptor (1) P2X Receptor (1) PI3K (2) Potassium Channel (2) PPAR (2) RAR/RXR (1) Reactive Oxygen Species (2) Small Interfering RNA (siRNA) (2) Sodium Channel (2) Tau Protein (2) TNF Receptor (1) TRP Channel (113)
By Research Areas:	Cancer (20) Cardiovascular Disease (6) Endocrinology (1) Infection (8) Inflammation/Immunology (33) Metabolic Disease (11) Neurological Disease (80)
Oligonucleotides:	Pre-designed siRNA Sets (1) siRNAs (3)

128

Inhibitors & Agonists

Peptides

Natural
Products

Isotope-Labeled Compounds

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-144372

TRPV1 antagonist 3	TRP Channel	Neurological Disease
TRPV1 antagonist 3 (Compound 7q) is a potent *TRPV1* antagonist with an IC₅₀ of 2.66 nM against capsaicin. TRPV1 antagonist 3 is mode-selective, oral bioavailable (F = 60%) and CNS-penetrant ^[1].

HY-148751

TRPV1 activator-1	TRP Channel	Cancer
TRPV1 activator-1 (compound 8), a capsaicin analog, has an altered neck structure. TRPV1 activator-1 interacts specifically with T551 residue ^[1].

HY-111218

TRPV1 antagonist 5	TRP Channel	Neurological Disease
TRPV1 antagonist 5 (compound 1) is a potent *TRPV1* antagonist ^[1].

HY-161420

TRPV1 antagonist 7	TRP Channel	Neurological Disease
TRPV1 antagonist 7 (Compound 36) is a selective *TRPV1* antagonist that effectively blocks capsaicin activation (IC₅₀=2.31 nM). TRPV1 antagonist 7 can be used in analgesic research ^[1].

HY-148752

TRPV1 activator-2	TRP Channel	Metabolic Disease
TRPV1 activator-2 (compound 9), a capsaicin head analog, makes specific interactions with channel residues at the lipid-water ^[1].

HY-161273

TRPV1 antagonist 6	TRP Channel	Neurological Disease
TRPV1 antagonist 6 (compound 51) is a mode-selective antagonist for transient receptor potential vanilloid member 1 (TRPV1), which shows antagonism with IC₅₀ of 2.85 nM to capsaicin activation and 28.48 % inhibition against proton activation at a 3 µM concentration ^[1].

HY-RS15121

TRPV1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
TRPV1 Human Pre-designed siRNA Set A contains three designed siRNAs for TRPV1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

TRPV1 Human Pre-designed siRNA Set A TRPV1 Human Pre-designed siRNA Set A

HY-P10465

TRPV1-Tat	TRP Channel	Inflammation/Immunology
TRPV1-Tat is an antagonistic peptide that fuses the *TRPV1* (transient receptor potential vanilla subtype 1) of the cell-penetrating peptide Tat. TRPV1-Tat blocks this phosphorylation process by competitively binding to the AKAP79 binding site of *TRPV1, thereby inhibiting the sensitization of TRPV1. TRPV1*-Tat can be used in the study of inflammatory pain ^[1].

HY-162856

TRPV1-IN-2	TRP Channel	Neurological Disease
TRPV1-IN-2 ((R)-32) is a *TRPV1* inhibitor. TRPV1-IN-2 has protective effects on ED epilepsy models ^[1].

HY-162908

TRPV1/CB2 agonist 1	TRP Channel Cannabinoid Receptor	Neurological Disease
TRPV1/CB2 agonist 1 (compound 41) is a *TRPV1/CB2* agonist, with an EC₅₀ of 26.8 μM for hTRPV1. TRPV1/CB2 agonist 1 can be used in nervous system related research ^[1].

HY-157766

*FAAH/TRPV1* blocker-1**	FAAH TRP Channel	Inflammation/Immunology
FAAH/TRPV1 blocker-1 (compound 2R) is a dual *FAAH/TRP*V1 blocker, with IC₅₀ of 0.12 and 94.9 μM, respectively. FAAH/TRPV1 blocker-1 plays an important role in analgesic and anti-inflammatory research ^[1].

HY-121122

A778317	Others	Others
A778317 is a *TRPV1* antagonists. A778317 can block changes in intracellular calcium levels mediated by TRPV1 receptors, with a pIC₅₀ value of 8.31. A-778317 can also block the activation of natural rat TRPV1 receptors in dorsal root ganglion neurons by capsaicin and acid ^[1].

HY-110209

AC4	TRP Channel	Others
AC4 is a trans antagonist upon voltageactivation of *TRPV1* and as cis antagonist of *TRPV1* currents upon stimulation with Capsaicin (HY-10448). AC4 demonstrates that a photoswitchable antagonist and an agonist can be used in concert ^[1].

HY-108453A

6'-Iodoresiniferatoxin 6'-IRTX	TRP Channel	Neurological Disease
6'-Iodoresiniferatoxin (6'-IRTX) is a *TRPV1* agonist used in the study of neuropathic pain ^[1].

HY-W747573

N-Linolenoylethanolamine 18:3 NAE; α-Linolenoyl ethanolamide	TRP Channel	Neurological Disease
N-Linolenoylethanolamine (18:3 NAE) is an endocannabinoid. N-Linolenoylethanolamine is a vanillin receptor (TRPV1) agonist ^[1].

HY-10635A

(S)-ABT-102	TRP Channel	Inflammation/Immunology Cancer
(S)-ABT-102 is a *TRPV1* Antagonist, with an IC₅₀ of 123 nM. (S)-ABT-102 has analgesic activity ^[1].

HY-P10654

RhTx	TRP Channel	Neurological Disease
RhTx is a transient receptor potential vanillin-1 (TRPV1) activator. RhTx can be used to study pain perception ^[1].

HY-118785

MSP-3	TRP Channel	Neurological Disease
MSP-3 is a potent *TRPV1* agonist, with an EC₅₀ of 0.87 μM. MSP-3 exhibits neuroprotective and antinociceptive effects ^[1].

HY-114630

Protokylol Caytine; JB-251	TRP Channel Adrenergic Receptor	Cardiovascular Disease
Protokylol (Caytine; JB-251) is a beta-adrenergic receptor agonist and *TRPV1* agonist. Protokylol is used as a bronchodilator ^[1].

HY-108448

N-Oleoyldopamine OLDA	TRP Channel	Cardiovascular Disease
N-Oleoyldopamine (OLDA) is a product of condensation of oleic acid and dopamine (DA) and an endogenous *TRPV1* selective agonist. N-Oleoyldopamine (OLDA) can crosses the blood-brain barrier. N-oleoyl-dopamine protects the heart against ischemia-reperfusion injury via activation of TRPV1 ^[1] .

HY-113654

AMG 7905	TRP Channel	Others
AMG 7905 is a hypothermia-inducing transient receptor potential vanilloid type 1 (TRPV1) antagonist. AMG 7905 potentiates *TRPV1* channels activation by protons and drives the reflectory inhibition of thermogenesis and tail-skin vasoconstriction, while potently blocking channel activation by capsaicin ^[1] .

HY-101323

Olvanil NE-19550; N-Vanillyloleamide	TRP Channel	Neurological Disease
Olvanil (NE-19550) is an analgesic and an agonist of transient receptor potential vanilloid type 1 (TRPV1) channels with an EC₅₀ of 0.7 nM ^[1].

HY-10448A

Capsaicin (Purity 65%) 15+ Cited Publications	TRP Channel Autophagy Apoptosis Endogenous Metabolite	Neurological Disease Inflammation/Immunology Cancer
Capsaicin (Purity 65%) is a mixture of Capsaicin and Dihydrocapsaicin (Ratio >2:1).Capsaicin (Purity 65%) is an orally active capsaicin receptor (TRPV1) agonist ^[1] .

HY-110292

A-425619	TRP Channel	Inflammation/Immunology
A-425619, a potent and selective *TRPV1* receptor antagonist, is effective in alleviating acute and chronic inflammatory pain and postoperative pain ^[1].

HY-108458

SB 452533	TRP Channel	Inflammation/Immunology
SB 452533 is a potent and selective *TRPV1* antagonist with the pK_b of 7.8 ^[1].

HY-123374

(Rac)-AMG 628	TRP Channel	Neurological Disease
(Rac)-AMG 628 is the racemate of AMG 628, a potent *TRPV1* antagonist with an IC₅₀ of 3.7nM. AMG 628 can be used in chronic pain research ^[1].

HY-132596A

Tivanisiran sodium SYL1001 sodium	TRP Channel	Neurological Disease
Tivanisiran sodium is a siRNA used for the study of dry eye disease. Tivanisiran sodium was designed to silence *transient receptor potential vanilloid 1 (TRPV1) mRNA* ^[1].

HY-132596

Tivanisiran SYL1001	Small Interfering RNA (siRNA) TRP Channel	Neurological Disease
Tivanisiran (SYL1001) is a siRNA used for the study of dry eye disease. Tivanisiran was designed to silence transient receptor potential vanilloid 1 (TRPV1) ^[1].

HY-108460

A-784168	TRP Channel	Neurological Disease
A-784168 is a potent and orally active inhibitor of vanilloid receptor type 1 (TRPV1). Vanilloid receptor type 1 (TRPV1) is a ligand-gated nonselective cation channel that is considered to be an important integrator of various pain stimuli such as endogenous lipids, capsaicin, heat, and low pH. A-784168 has good CNS penetration ^[1].

HY-109841

Oleoyl serotonin	TRP Channel	Neurological Disease
Oleoyl Serotonin is a *TRPV1* antagonist with IC₅₀ value of 2.57 μM for human TRPV1 ^[1].

HY-12428

A-1165442 2 Publications Verification	TRP Channel	Neurological Disease
A-1165442 is a potent, competitive and orally available *TRPV1* antagonist with an IC₅₀ of 9 nM for human TRPV1.

HY-128479

JYL-273	Others	Neurological Disease
JYL-273 is a *TRPV1* agonist, with the IC₅₀ of 361 nM in CHO-TRPV1 cell lines ^[1].

HY-124382

AS1928370	TRP Channel	Neurological Disease
AS1928370 is a novel and central nervous system (CNS) penetrant *TRPV1* antagonist and can prevent ligand-induced activation in vivo. AS1928370 is a promising agent for neuropathic pain treatment research ^[1].

HY-101389

(R)-Methanandamide AM-356	Cannabinoid Receptor TRP Channel	Neurological Disease
(R)-Methanandamide (AM-356), an analog of the endocannabinoid ligand Anandamide, is a potent *CB1* agonist with a K_i of 20 nM. (R)-Methanandamide also activates *vanilloid (TRPV1) receptors* ^[1] .

HY-16413

Protokylol hydrochloride Caytine hydrochloride; JB-251 hydrochloride	TRP Channel Adrenergic Receptor	Others
Protokylol hydrochloride (Caytine hydrochloride; JB-251 hydrochloride) is the hydrochloride salt form of Protokylol (HY-114630). Protokylol hydrochloride is an agonist for β2-adrenergic receptor and *TRPV1*. Protokylol hydrochloride exhibits activity as a bronchodilator ^[1].

HY-10448

Capsaicin Maximum Cited Publications 39 Publications Verification (E)-Capsaicin	TRP Channel Autophagy Apoptosis Endogenous Metabolite	Neurological Disease Inflammation/Immunology Cancer
Capsaicin ((E)-Capsaicin), an active component of chili peppers, is a *TRPV1* agonist. Capsaicin has pain-relieving, antioxidant, anti-inflammatory, anti-cancer and certain neurotoxic effects ^[1] .

HY-101736

AMG9810 4 Publications Verification	TRP Channel	Neurological Disease
AMG9810 is a selective and competitive vanilloid receptor 1 (TRPV1) antagonist with IC₅₀ values of 24.5 and 85.6 nM for human and rat TRPV1, repectively.

HY-10448AR

Capsaicin (Purity 65%) (Standard)	TRP Channel Autophagy Apoptosis Endogenous Metabolite	Neurological Disease Inflammation/Immunology Cancer
Capsaicin (Purity 65%) (Standard) is the analytical standard of Capsaicin (Purity 65%). This product is intended for research and analytical applications. Capsaicin (Purity 65%) is a mixture of Capsaicin and Dihydrocapsaicin (Ratio >2:1).Capsaicin (Purity 65%) is an orally active capsaicin receptor (TRPV1) agonist ^[1] .

HY-121636

Resolvin D2 RvD2	TRP Channel	Infection Neurological Disease Inflammation/Immunology
Resolvin D2 is a metabolite of docosahexaenoic acid (DHA), with anti-inflammatory, anti-infective activities. Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis. Resolvin D2 is a remarkably potent inhibitor of *TRPV1* (IC₅₀ = 0.1 nM) and *TRPA1* (IC₅₀ = 2 nM) in primary sensory neurons ^[1] .

HY-108453

5-Iodoresiniferatoxin I-RTX	TRP Channel	Neurological Disease
5-Iodoresiniferatoxin (I-RTX) is a selective *TRPV1* antagonist, with an IC₅₀s of 0.7 and 5.4 nM for rat and human receptors, respectively. 5-Iodoresiniferatoxin induces TRPV1-dependent hypothermia in vivo ^[1].

HY-117683

BCTP	TRP Channel	Neurological Disease
BCTP is a *TRPV1* antagonist. BCTP activated at low pH showed functional antagonist activity against human *TRPV1* in CHO cells (IC₅₀=18 nM). BCTP can be used in the study of chronic pain ^[1].

HY-100668

JYL 1421 SC 0030	TRP Channel	Neurological Disease
JYL 1421 is a TRPV1 receptor antagonist, with an IC₅₀ of 8 nM.

HY-111038

Capsiconiate Coniferyl (E)-8-methyl-6-nonenoate	TRP Channel	Neurological Disease Inflammation/Immunology
Capsiconiate (Coniferyl (E)-8-methyl-6-nonenoate) is a *TRPV1* agonist (EC₅₀= 3.2 μM). Capsiconiate can be used to study TRPV1-mediated diseases such as pain, inflammation, and epilepsy(EC₅₀= 3.2 μM) ^[1].

HY-10448S4

Capsaicin-d7 (E)-Capsaicin-d₇	TRP Channel Autophagy Endogenous Metabolite Apoptosis Isotope-Labeled Compounds	Cancer
Capsaicin-d₇ is deuterated labeled Capsaicin (HY-10448). Capsaicin ((E)-Capsaicin), an active component of chili peppers, is a *TRPV1* agonist. Capsaicin has pain relief, antioxidant, anti-inflammatory, neuroprotection and anti-cancer effects ^[1] .

HY-19589

JTS-653	TRP Channel	Neurological Disease Inflammation/Immunology
JTS-653 is a highly potent and selective transient receptor potential vanilloid 1 (TRPV1) antagonist in vitro and in vivo. JTS-653 attenuates chronic pain refractory to non-steroidal anti-inflammatory agents ^[1].

HY-N2333

Resiniferatoxin 1 Publications Verification (+)-Resiniferatoxin	TRP Channel	Cardiovascular Disease
Resiniferatoxin ((+)-Resiniferatoxin), is a selective agonist of *transient receptor potential vanilloid 1 (TRPV1) receptor* agonist. Resiniferatoxin can be isolated from the Euphorbia resinifera plant. Resiniferatoxin eliminates TRPV1+ primary sensory afferents and blunt cardiac sympathetic afferent reflex for a relatively long period ^[1] .

HY-15640

Capsazepine 30+ Cited Publications	TRP Channel Apoptosis	Cancer
Capsazepine is a synthetic analogue of the sensory neurone excitotoxin, and an antagonist of TRPV1 receptor with an IC₅₀ of 562 nM.

HY-N0172

Caffeic acid 3 Publications Verification	TRP Channel Lipoxygenase Endogenous Metabolite	Inflammation/Immunology Cancer
Caffeic acid is an inhibitor of both *TRPV1* ion channel and 5-Lipoxygenase (5-LO).

HY-W554764

Cyclo(-asp-gly)	TRP Channel	Neurological Disease
Cyclo(-asp-gly) is a cyclic dipeptide composed of amino acids and is a potential TRPV1 stimulator ^[1].

HY-10634

AMG 517 5+ Cited Publications	TRP Channel	Neurological Disease
AMG 517 is a potent and selective vanilloid receptor-1 (TRPV1) antagonist with an IC₅₀ of 0.5 nM.

Cat. No.	Product Name	Target	Research Area

HY-P3467

(Thr4,Gly7)-Oxytocin	Oxytocin Receptor Potassium Channel	Neurological Disease
(Thr4,Gly7)-Oxytocin, an Oxytocin analogue, is a specific OT receptor agonist. (Thr4,Gly7)-Oxytocin also excites subicular neurons via activation of TRPV1 channels, and depression of K ⁺ channels. ^[1] .

HY-P1441A

Mambalgin 1 TFA	Sodium Channel	Neurological Disease
Mambalgin 1 TFA is a selective ASIC1a inhibitor (IC₅₀ values are 192 and 72 nM for human ASIC1a and ASIC1a/1b dimer, respectively). Mambalgin 1 TFA binds to closed/inactive channel. Mambalgin 1 TFA is selective for ASIC1a over ASIC2a, ASIC3, TRPV1, P2X2, 5-HT3, Nav1.8, Cav3.2 and Kv1.2 channels. Mambalgin 1 TFA increases latency of withdrawal response in mouse tail-flick and paw-flick tests.

HY-P10465

TRPV1-Tat	TRP Channel	Inflammation/Immunology
TRPV1-Tat is an antagonistic peptide that fuses the *TRPV1* (transient receptor potential vanilla subtype 1) of the cell-penetrating peptide Tat. TRPV1-Tat blocks this phosphorylation process by competitively binding to the AKAP79 binding site of *TRPV1, thereby inhibiting the sensitization of TRPV1. TRPV1*-Tat can be used in the study of inflammatory pain ^[1].

HY-P10654

RhTx	TRP Channel	Neurological Disease
RhTx is a transient receptor potential vanillin-1 (TRPV1) activator. RhTx can be used to study pain perception ^[1].

HY-P10464

Tat-AKAP79 (326-336)	TRP Channel	Neurological Disease Inflammation/Immunology
TAT-AKAP79 326-336 is a cytoosmotic peptide. TAT-AKAP79 326-336 mimics a specific region on the AKAP79 protein that binds to TRPV1 ion channels (amino acid sequence 326-336). TAT-AKAP79 326-336 inhibits the sensitization of *TRPV1* and reduce the overresponse of *TRPV1* channels to stimuli caused by the activation of cellular kinases such as protein kinase A (PKA) and protein kinase C (PKC) by inflammatory mediators. TAT-AKAP79 326-336 can be used to study the mechanism of pain transduction and inflammatory hyperalgesia ^[1].

HY-P1175

L-R4W2	TRP Channel	Neurological Disease
L-R4W2 is a potent antagonist of vanilloid receptor 1 (VR1, TRPV1), with an IC₅₀ of 0.1 μM. L-R4W2 may act as a potent analgesic ^[1] .

HY-P1175A

L-R4W2 TFA	TRP Channel	Neurological Disease
L-R4W2 TFA is a potent antagonist of vanilloid receptor 1 (VR1, TRPV1), with an IC₅₀ of 0.1 μM. L-R4W2 TFA may act as a potent analgesic ^[1] .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-10448A

Capsaicin (Purity 65%) 15+ Cited Publications	Structural Classification Monophenols Capsicum annuum L. Neurological Disease Classification of Application Fields Source classification Phenols Solanaceae Plants Inflammation/Immunology Disease Research Fields	TRP Channel Autophagy Apoptosis Endogenous Metabolite
Capsaicin (Purity 65%) is a mixture of Capsaicin and Dihydrocapsaicin (Ratio >2:1).Capsaicin (Purity 65%) is an orally active capsaicin receptor (TRPV1) agonist ^[1] .

HY-10448

Capsaicin Maximum Cited Publications 39 Publications Verification (E)-Capsaicin	Structural Classification Monophenols Capsicum annuum L. Classification of Application Fields Source classification Phenols Solanaceae Plants Disease Research Fields Biological Pesticide Research Cancer Agricultural Research	TRP Channel Autophagy Apoptosis Endogenous Metabolite
Capsaicin ((E)-Capsaicin), an active component of chili peppers, is a *TRPV1* agonist. Capsaicin has pain-relieving, antioxidant, anti-inflammatory, anti-cancer and certain neurotoxic effects ^[1] .

HY-N2333

Resiniferatoxin 1 Publications Verification (+)-Resiniferatoxin	Cardiovascular Disease Euphorbia resinifera O. Berg Classification of Application Fields Source classification Euphorbiaceae Plants Disease Research Fields	TRP Channel
Resiniferatoxin ((+)-Resiniferatoxin), is a selective agonist of *transient receptor potential vanilloid 1 (TRPV1) receptor* agonist. Resiniferatoxin can be isolated from the Euphorbia resinifera plant. Resiniferatoxin eliminates TRPV1+ primary sensory afferents and blunt cardiac sympathetic afferent reflex for a relatively long period ^[1] .

HY-N0172

Caffeic acid 3 Publications Verification	Structural Classification Classification of Application Fields Anti-aging Food Preservation Research Source classification Plants Endogenous metabolite Agricultural Research Human Gut Microbiota Metabolites Microorganisms other families Simple Phenylpropanols Sunscreen Phenols Polyphenols Phenylpropanoids Cosmetic Research Inflammation/Immunology Disease Research Fields Cancer	TRP Channel Lipoxygenase Endogenous Metabolite
Caffeic acid is an inhibitor of both *TRPV1* ion channel and 5-Lipoxygenase (5-LO).

HY-124073

Dihydrocapsiate	Structural Classification Monophenols Capsicum annuum L. Classification of Application Fields Source classification Phenols Metabolic Disease Plants Solanaceae Disease Research Fields	TRP Channel
Dihydrocapsiate, as a compound of capsinoid family, is an orally active *TRPV1* agonist. Dihydrocapsiate can be used for the research of metabolism disease ^[1].

HY-17568

Nonivamide Pelargonic acid vanillylamide; Nonanoic acid vanillylamide; Pseudocapsaicin	Alkaloids Structural Classification Monophenols Capsicum annuum L. Other Alkaloids Source classification Phenols Solanaceae Plants	TRP Channel
Nonivamide is a agonist, which exhibits 4d-EC₅₀ value of 5.1 mg/L in static toxicity tests.

HY-N8377

Capsiate 1 Publications Verification	Structural Classification Monophenols Capsicum annuum L. Classification of Application Fields Source classification Phenols Solanaceae Plants Inflammation/Immunology Disease Research Fields	TRP Channel
Capsiate, as a capsaicin analogue extracted from a non-pungent cultivar of CH-19 sweet red pepper, is an orally active agonist of *TRPV1* ^[1].

HY-10448AR

Capsaicin (Purity 65%) (Standard)	Structural Classification Monophenols Capsicum annuum L. Source classification Phenols Solanaceae Plants	TRP Channel Autophagy Apoptosis Endogenous Metabolite
Capsaicin (Purity 65%) (Standard) is the analytical standard of Capsaicin (Purity 65%). This product is intended for research and analytical applications. Capsaicin (Purity 65%) is a mixture of Capsaicin and Dihydrocapsaicin (Ratio >2:1).Capsaicin (Purity 65%) is an orally active capsaicin receptor (TRPV1) agonist ^[1] .

HY-111038

Capsiconiate Coniferyl (E)-8-methyl-6-nonenoate	Structural Classification Monophenols Source classification Phenols Plants Solanaceae Capsicum baccatum L.	TRP Channel
Capsiconiate (Coniferyl (E)-8-methyl-6-nonenoate) is a *TRPV1* agonist (EC₅₀= 3.2 μM). Capsiconiate can be used to study TRPV1-mediated diseases such as pain, inflammation, and epilepsy(EC₅₀= 3.2 μM) ^[1].

HY-137988

Palvanil	Monophenols Capsicum annuum L. Source classification Solanaceae Plants	TRP Channel
Palvanil is a Capsaicin (HY-10448) analogue, shows strong desensitizing capability against the TRPV1 receptor. Palvanil shows anti-nociceptive and anti-inflammation effects ^[1] .

HY-124073R

Dihydrocapsiate (Standard)	Structural Classification Monophenols Capsicum annuum L. Source classification Phenols Solanaceae Plants	TRP Channel
Dihydrocapsiate (Standard) is the analytical standard of Dihydrocapsiate. This product is intended for research and analytical applications. Dihydrocapsiate, as a compound of capsinoid family, is an orally active TRPV1 agonist. Dihydrocapsiate can be used for the research of metabolism disease ^[1].

HY-N7536

Voacangine	Alkaloids Structural Classification other families Classification of Application Fields Source classification Other Diseases Plants Disease Research Fields Indole Alkaloids	TRP Channel
Voacangine is an antagonist for *TRPV1* and TRPM8 but as an agonist for *TRPA1* (EC₅₀=8 μM). Voacangine competitively blockes capsaicin binding to *TRPV1* (IC₅₀=50 μM). Voacangine competitively inhibits the binding of menthol to TRPM8 (IC₅₀=9 μM) and it shows noncompetitive inhibition against icilin (IC₅₀=7 μM). Voacangine selectively abrogates chemical agonist-induced TRPM8 activation and did not affect cold-induced activation. Voacangine is an alkaloid isolated from the root bark of Voacanga africana ^[1].

HY-17568R

Nonivamide (Standard)	Alkaloids Structural Classification Monophenols Capsicum annuum L. Other Alkaloids Source classification Phenols Solanaceae Plants	TRP Channel
Nonivamide (Standard) is the analytical standard of Nonivamide. This product is intended for research and analytical applications. Nonivamide is a <b<TRPV1 agonist, which exhibits 4d-EC50 value of 5.1 mg/L in static toxicity tests.

HY-N8377R

Capsiate (Standard)	Structural Classification Monophenols Capsicum annuum L. Source classification Phenols Solanaceae Plants	TRP Channel
Capsiate (Standard) is the analytical standard of Capsiate. This product is intended for research and analytical applications. Capsiate, as a capsaicin analogue extracted from a non-pungent cultivar of CH-19 sweet red pepper, is an orally active agonist of TRPV1 ^[1].

HY-N0285

Imperatorin 2 Publications Verification Ammidin	Structural Classification Source classification Coumarins Phenylpropanoids Umbelliferae Helogyne apaloidea Nutt. Plants	Cholinesterase (ChE) TRP Channel
Imperatorin is an effective of NO synthesis inhibitor (IC₅₀=9.2 μmol), which also is a BChE inhibitor (IC₅₀=31.4 μmol). Imperatorin is a weak agonist of *TRPV1* with EC₅₀ of 12.6±3.2 μM.

HY-N0447

8-Gingerol 1 Publications Verification	Zingiber officinale Roscoe Structural Classification Monophenols Classification of Application Fields Source classification Phenols Plants Inflammation/Immunology Disease Research Fields Zingiberaceae Cancer	TRP Channel Bacterial
8-Gingerol, found in the rhizomes of ginger (Z. officinale) with oral bioavailability, activates *TRPV1, with an EC₅₀ of 5.0 µM. 8-Gingerol inhibits COX-2, and inhibits the growth of H. pylori* in vitro ^[1] .

HY-120294

Chrysin 6-C-glucoside 8-C-arabinoside	Structural Classification Flavonoids Rheum palmatum L. Flavones Polygonaceae Source classification Plants	CGRP Receptor TRP Channel
Chrysin 6-C-glucoside 8-C-arabinoside can inhibit the CGRP releasing and the activation of *TRPV1* channel. Chrysin 6-C-glucoside 8-C-arabinoside can be used for anti-migraine research ^[1].

HY-N6825

Hydroxy-α-sanshool 3 Publications Verification	Zanthoxylum bungeanum Maxim. Alkaloids Structural Classification Other Alkaloids Source classification Rutaceae Plants Endogenous metabolite	TRP Channel Endogenous Metabolite
Hydroxy-α-sanshool is a transient receptor potential ankyrin 1 (TRPA1) and TRP vanilloid 1 (TRPV1) agonist with EC₅₀s of 69 and 1.1 μM, respectively. Hydroxy-α-sanshool can be used for pain research ^[1] .

HY-10448R

Capsaicin (Standard) Maximum Cited Publications 39 Publications Verification (E)-Capsaicin (Standard)	Structural Classification Capsicum annuum L. Classification of Application Fields Source classification Phenols Solanaceae Plants Disease Research Fields Biological Pesticide Research Cancer Agricultural Research	TRP Channel Autophagy Apoptosis Endogenous Metabolite
Capsaicin (Standard) is the analytical standard of Capsaicin. This product is intended for research and analytical applications. Capsaicin ((E)-Capsaicin), an active component of chili peppers, is a *TRPV1* agonist. Capsaicin has pain relief, antioxidant, anti-inflammatory, neuroprotection and anti-cancer effects ^[1] .

HY-135882

OMDM-6	Structural Classification Alkaloids Monophenols Neurological Disease Classification of Application Fields Other Alkaloids Source classification Phenols Endogenous metabolite Disease Research Fields	TRP Channel Cannabinoid Receptor Endogenous Metabolite
OMDM-6 is a hybrid agonist of vanilloid receptor type 1 (VR1, TRPV1) (EC₅₀=75 nM) and cannabinoid receptor type 1 (CB1) (K_i=3.2 μM). OMDM-6 inhibits anandamide cellular uptake (ACU) with a K_i of 7.0 μM ^[1].

HY-N0285R

Imperatorin (Standard)	Structural Classification Source classification Coumarins Phenylpropanoids Umbelliferae Helogyne apaloidea Nutt. Plants	Cholinesterase (ChE) TRP Channel
Imperatorin (Standard) is the analytical standard of Imperatorin. This product is intended for research and analytical applications. Imperatorin is an effective of NO synthesis inhibitor (IC50=9.2 μmol), which also is a BChE inhibitor (IC50=31.4 μmol). Imperatorin is a weak agonist of TRPV1 with EC50 of 12.6±3.2 μM.

HY-135881

OMDM-5	Structural Classification Alkaloids Monophenols Neurological Disease Classification of Application Fields Other Alkaloids Source classification Phenols Endogenous metabolite Disease Research Fields	TRP Channel Endogenous Metabolite
OMDM-5 is a selective inhibitor of anandamide cellular uptake (ACU), with a K_i of 4.8 μM. OMDM-5 is also a potent vanilloid receptor type 1 (VR1, TRPV1) agonist, with an EC₅₀ of 75 nM, and shows weakly active as cannabinoid receptor type 1 (CB1) ligand (K_i=4.9 μM) ^[1].

HY-N0447R

8-Gingerol (Standard)	Zingiber officinale Roscoe Structural Classification Monophenols Source classification Phenols Plants Zingiberaceae	TRP Channel Bacterial
8-Gingerol (Standard) is the analytical standard of 8-Gingerol. This product is intended for research and analytical applications. 8-Gingerol, found in the rhizomes of ginger (Z. officinale) with oral bioavailability, activates TRPV1, with an EC₅₀ of 5.0 μM. 8-Gingerol inhibits COX-2, and inhibits the growth of H. pylori in vitro ^[1] .

HY-N8264

Moringin 1 Publications Verification	Structural Classification Natural Products Neurological Disease Classification of Application Fields Moringa oleifera Lam. Source classification Moringaceae Plants Inflammation/Immunology Disease Research Fields	TRP Channel
Moringin is a potent and selective TRPA1 ion channel natural agonist with an EC₅₀ of 3.14 μM. Moringin does not activate or activates very weakly the vanilloids somatosensory channels TRPV1, TRPV2, TRPV3 and TRPV4, and the melastatin cooling receptor TRPM8. Moringin has hypoglycemic, antimicrobial, anti-inflammatory, anticancer and neuroprotection activities ^[1] .

HY-N0361

Dihydrocapsaicin 2 Publications Verification	Alkaloids Structural Classification Monophenols Capsicum annuum L. Classification of Application Fields Other Alkaloids Source classification Phenols Metabolic Disease Solanaceae Plants Disease Research Fields	TRP Channel Reactive Oxygen Species Apoptosis Caspase Bcl-2 Family Akt PI3K
Dihydrocapsaicin, a capsaicin, is a potent and selective *TRPV1* (transient receptor potential vanilloid channel 1) agonist. Dihydrocapsaicin reduces AIF, Bax, and Caspase-3 expressions, and increased Bcl-2, Bcl-xL and p-Akt levels. Dihydrocapsaicin enhances the hypothermia-induced neuroprotection following ischemic stroke via PI3K/Akt regulation in rat ^[1] .

HY-N6962

α-Spinasterol	Structural Classification Natural Products Plants Caryophyllaceae Melandrium firmum (S. et Z . ) Rohrb.	TRP Channel COX Bacterial
α-Spinasterol is an orally taken antagonist of transient receptor potential vanilloid 1 ( *TRPV1), and it's also an inhibitor of COX-1* and COX-2, with IC₅₀ values of 16.17 μM and 7.76 μM, respectively. α-Spinasterol exhibits antibacterial, anti-inflammatory, antidepressant, and antioxidant effects, has the ability to cross the blood-brain barrier, and can improve diabetes in mice ^[1] .

HY-10863

Anandamide 1 Publications Verification AEA	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Cannabinoid Receptor PPAR TRP Channel GPR55 Fungal Tau Protein Endogenous Metabolite
Anandamide is an endocannabinoid. Anandamide modulates both neuronal and immune functions through two protein-coupled cannabinoid receptors (CB1 and CB2). Anandamide can activate numerous other receptors like PPARS, *TRPV1, and GPR18/GPR55. Anandamide also has potential anti-fungal* and anti-inflammatory activities. Anandamide can be used for the research of Alzheimer’s disease (AD) and ulcerative colitis ^[1] .

HY-N0361R

Dihydrocapsaicin (Standard)	Alkaloids Structural Classification Monophenols Capsicum annuum L. Other Alkaloids Source classification Phenols Solanaceae Plants	TRP Channel Reactive Oxygen Species Apoptosis Caspase Bcl-2 Family Akt PI3K
Dihydrocapsaicin (Standard) is the analytical standard of Dihydrocapsaicin. This product is intended for research and analytical applications. Dihydrocapsaicin, a capsaicin, is a potent and selective TRPV1 (transient receptor potential vanilloid channel 1) agonist. Dihydrocapsaicin reduces AIF, Bax, and Caspase-3 expressions, and increased Bcl-2, Bcl-xL and p-Akt levels. Dihydrocapsaicin enhances the hypothermia-induced neuroprotection following ischemic stroke via PI3K/Akt regulation in rat ^[1] .

HY-124001

N-Docosanoyl taurine	Structural Classification Natural Products Source classification Endogenous metabolite	TRP Channel
N-Docosanoyl taurine is a lipoamino acid. N-Docosanoyl taurine is a discriminatory metabolity that drive the classification of brain regions ^[1].

Cat. No.	Product Name	Chemical Structure

HY-10448S4

Capsaicin-d7
Capsaicin-d₇ is deuterated labeled Capsaicin (HY-10448). Capsaicin ((E)-Capsaicin), an active component of chili peppers, is a *TRPV1* agonist. Capsaicin has pain relief, antioxidant, anti-inflammatory, neuroprotection and anti-cancer effects ^[1] .

HY-10448S1

Capsaicin-d3
Capsaicin-d₃ is the deuterium labeled Capsaicin. Capsaicin ((E)-Capsaicin), an active component of chili peppers, is a TRPV1 agonist. Capsaicin has pain relief, antioxidant, anti-inflammatory, neuroprotection and anti-cancer effects[1][2].

HY-121636S

Resolvin D2-d5
Resolvin D2-d₅ is the deuterium labeled Resolvin D2. Resolvin D2 is a metabolite of docosahexaenoic acid (DHA), with anti-inflammatory, anti-infective activities. Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis. Resolvin D2 is a remarkably potent inhibitor of TRPV1 (IC50 = 0.1 nM) and TRPA1 (IC50 = 2 nM) in primary sensory neurons[1][2][3].

HY-N0361S

Dihydrocapsaicin-d3

Dihydrocapsaicin-d₃is the deuterium labeledDihydrocapsaicin(HY-N0361) ^[1]. Dihydrocapsaicin, a capsaicin, is a potent and selective TRPV1 (transient receptor potential vanilloid channel 1) agonist. Dihydrocapsaicin reduces AIF, Bax, and Caspase-3 expressions, and increased Bcl-2, Bcl-xL and p-Akt levels. Dihydrocapsaicin enhances the hypothermia-induced neuroprotection following ischemic stroke via PI3K/Akt regulation in rat .

HY-10863S

Anandamide-d8

Anandamide-d8 is a deuterated labeled Anandamide ^[1]. Anandamide is an endocannabinoid. Anandamide modulates both neuronal and immune functions through two protein-coupled cannabinoid receptors (CB1 and CB2). Anandamide can activate numerous other receptors like PPARS, TRPV1, and GPR18/GPR55. Anandamide also has potential anti-fungal and anti-inflammatory activities. Anandamide can be used for the research of Alzheimer’s disease (AD) and ulcerative colitis .

Cat. No.	Product Name		Classification