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Pathways Recommended:	Stem Cell/Wnt Cell Cycle/DNA Damage

Results for "

Vero cells

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (1) Amyloid-β (1) Antibiotic (8) Apoptosis (8) Arenavirus (2) Bacterial (13) Bcl-2 Family (5) Biochemical Assay Reagents (1) Calcium Channel (1) Cathepsin (2) CDK (6) Dengue virus (4) DNA Methyltransferase (2) Elastase (1) Endogenous Metabolite (1) Estrogen Receptor/ERR (2) Flavivirus (5) Fungal (1) HCV (2) HIV (4) HIV Protease (1) HSV (5) iGluR (1) Influenza Virus (11) Interleukin Related (1) Isotope-Labeled Compounds (1) Lipoxygenase (1) NF-κB (1) Orthopoxvirus (7) p38 MAPK (1) Parasite (18) RSV (2) SARS-CoV (29) Ser/Thr Protease (3) Sodium Channel (1) STAT (7) Virus Protease (7)
By Research Areas:	Cancer (24) Cardiovascular Disease (3) Endocrinology (2) Infection (77) Inflammation/Immunology (6) Metabolic Disease (2) Neurological Disease (8)
Click Chemistry:	Azide (2) Alkynes (1)

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Targets Recommended: Nuclear Factor of activated T Cells (NFAT)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-150306

IM-250	HSV	Infection
IM-250 is an orally active helicase-primase inhibitor. IM-250 is effective against HSV infection. IM-250 inhibits HSV-1 infection in Vero cells (IC₅₀: ~20 nM) .

HY-138102

SSAA09E3	SARS-CoV	Infection
SSAA09E3 is a SARS-CoV entry inhibitor that inhibits SARS/HIV pseudotyped virus entry with an EC₅₀ of 9.7 μM in 293T cells and inhibits SARS-CoV infection of Vero cells with an EC₅₀ of 0.15 μM .

HY-135855

SARS-CoV-IN-1 1 Publications Verification	SARS-CoV Parasite	Infection
SARS-CoV-IN-1 is an effective inhibitor of SARS-CoV replication. SARS-CoV-IN-1 shows anti-Coronavirus activity with an EC₅₀ of 4.9 μM in Vero cells. SARS-CoV-IN-1 inhibits the 3D7 and W2 strains of P. falciparum with IC₅₀s of 15.4 and 133.2 nM; and IC₉₀s of 25.7 and 459.1 nM; respectively. Antimalarial and antiviral activities .

HY-135858

SARS-CoV-IN-3 1 Publications Verification	SARS-CoV Parasite HIV	Infection
SARS-CoV-IN-3 is an effective inhibitor of SARS-CoV replication. SARS-CoV-IN-3 shows anti-Coronavirus activity with an EC₅₀ of 3.6 μM in Vero cells. SARS-CoV-IN-3 inhibits the 3D7 and W2 strains of P. falciparum with IC₅₀s of 11.7 and 20.4 nM; and IC₉₀s of 29.19 and 56 nM; respectively. SARS-CoV-IN-3 reduces HIV-1-induced cytopathic effect with an EC₅₀ of 10 μM in MT-4 cells .

HY-135856

SARS-CoV-IN-2 1 Publications Verification	SARS-CoV Parasite HIV	Infection
SARS-CoV-IN-2 is an effective inhibitor of SARS-CoV replication. SARS-CoV-IN-2 shows anti-Coronavirus activity with an EC₅₀ of 1.9 μM in Vero cells. SARS-CoV-IN-2 inhibits the 3D7 and W2 strains of P. falciparum with IC₅₀s of 21.5 and 30 nM; and IC₉₀s of 51.0 and 99.9 nM; respectively. SARS-CoV-IN-2 reduces HIV-1-induced cytopathic effect with an EC₅₀ of 2.9 μM in MT-4 cells. Antimalarial and Antiviral Activities .

HY-141841

SARS-CoV-2-IN-7	SARS-CoV	Infection
SARS-CoV-2-IN-7 inhibits viral replication with a nanomolar IC₅₀ value (844 nM) in SARS-CoV-2-infected Vero E6 cells.

HY-155119

SARS-CoV-2-IN-54	SARS-CoV	Infection
SARS-CoV-2-IN-54 (Compound 2) is a SARS-CoV-2 inhibitor. SARS-CoV-2-IN-54 has antiviral activity. SARS-CoV-2-IN-54 inhibits SARS-CoV-2 in Vero E6 cells, with an IC₅₀ of 21.4 μM .

HY-155121

SARS-CoV-2-IN-56	SARS-CoV	Infection
SARS-CoV-2-IN-56 (Compound 63) is a SARS-CoV-2 inhibitor. SARS-CoV-2-IN-56 has antiviral activity. SARS-CoV-2-IN-56 inhibits SARS-CoV-2 in Vero E6 cells, with an IC₅₀ of 0.7 μM .

HY-149058

Neuraminidase-IN-13	Influenza Virus	Infection
Neuraminidase-IN-13 (Compound 10) is a neuraminidase inhibitor with antiviral activity and low cytotoxicity. Neuraminidase-IN-13 significantly inhibits NDV infection of Vero cells by preventing the release of viral particles from infected cells . Neuraminidase-IN-13 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-N9394

(+)-Norlirioferine	Others	Others
(+)-Norlirioferine is an alkaloid compound. (+)-Norlirioferine inhibits the cell growth of macrophages and VERO cells .

HY-N1716

2′′-Acetylastragalin	Parasite	Infection
2’’-Acetylastragalin (Compound 2) is a compound isolated from the aerial parts of Delphinium staphisagria, with an IC₅₀ value of 6.5 μM for Vero cells. 2’’-Acetylastragalin has trypanoidal activity .

HY-W011100

Cyclofenil	Dengue virus Estrogen Receptor/ERR Flavivirus	Infection Endocrinology
Cyclofenil is a selective estrogen receptor modulator and an ovulation-inducing agent. Cyclofenil shows an inhibitory effect on dengue virus replication in Vero cells with an EC₅₀ of 1.62 μM. Cyclofenil has anti-dengue-virus activity .

HY-N10351

27-O-(tert-Butyldimethylsilyl)withaferin A	Apoptosis	Cancer
27-O-(tert-Butyldimethylsilyl)withaferin A (compound 9a), a natural withanolide, is an apoptosis inducer. 27-O-(tert-Butyldimethylsilyl)withaferin A shows antiproliferative activity against HeLa, A-549 and MCF-7 human cancer cell lines, and against normal Vero cells .

HY-B1123

Auranofin 25+ Cited Publications SKF-39162	Bacterial SARS-CoV	Infection Inflammation/Immunology Cancer
Auranofin (SKF-39162) is a thioredoxin reductase (TrxR) inhibitor with an IC₅₀ of 0.2 μM. Auranofin exhibits antiviral activity against SARS-CoV21, with a CC₅₀ of 4.2 μM for monkey kidney Vero E6 cells.

HY-117105

DAPD-NHc-pr	HIV	Infection
DAPD-NHc-pr (compound 12) is an HIV inhibitor with EC₅₀/EC90 values of 0.85 μM and 13 μM, respectively. DAPD-NHc-pr shows no toxicity to normal cells (PBM, CEM, VERO) .

HY-169246

CDK2-IN-32	CDK Apoptosis	Cancer
CDK2-IN-32 (Compound 5g) is a selective CDK2 inhibitor with an IC₅₀ of 0.21 μM. CDK2-IN-32 shows cytotoxicity against Vero cells with an IC₅₀ of 28.52 μM .

HY-B0497

Niclosamide 25+ Cited Publications BAY2353	STAT Parasite Antibiotic	Infection Cancer
Niclosamide (BAY2353) is an orally active antihelminthic agent used in parasitic infection research . Niclosamide is a STAT3 inhibitor with an IC₅₀ of 0.25 μM in HeLa cells . Niclosamide has biological activities against cancer, inhibits DNA replication in Vero E6 cells .

HY-B0497B

Niclosamide monohydrate BAY2353 monohydrate	STAT Antibiotic Parasite	Infection Cancer
Niclosamide (BAY2353) monohydrate is an orally active antihelminthic agent used in parasitic infection research . Niclosamide monohydrate is a STAT3 inhibitor with an IC₅₀ of 0.25 μM in HeLa cells . Niclosamide monohydrate has biological activities against cancer, and inhibits DNA replication in Vero E6 cells .

HY-146104

Antimycobacterial agent-1	Bacterial	Infection
Antimycobacterial agent-1 (compound 33) has selectively antimycobacterial activity against Mycobacterium tuberculosis (M. tuberculosis) H37Ra with a MIC value of 1 μg/ml. Antimycobacterial agent-1 has relatively low cytotoxicity in normal cells (Vero cells IC₅₀ = 143.2 μg/ml) .

HY-B0497A

Niclosamide sodium BAY2353 sodium	Antibiotic STAT Parasite	Infection Cancer
Niclosamide (BAY2353) sodium is an orally active antihelminthic agent used in parasitic infection research . Niclosamide sodium is a STAT3 inhibitor with an IC₅₀ of 0.25 μM in HeLa cells . Niclosamide sodium has biological activities against cancer, and inhibits DNA replication in Vero E6 cells .

HY-N7302

Anthracophyllone	Others	Cancer
Anthracophyllone is an aristolane sesquiterpene that can be isolated from the mushroom Anthracophyllum. Anthracophyllone has cytotoxicity against MCF-7, KB, NCI-H187, Vero cells (IC₅₀: 32.97, 18.02, 15.17, 18.06 μM) .

HY-146374

Antibacterial agent 96	Bacterial	Infection
Antibacterial agent 96 (compound 4k) is a potent antibacterial agent. Antibacterial agent 96 shows antitubercular activity against agent-susceptible and multidrug-resistantMycobacterium tuberculosis (M. tuberculosis) strains. Antibacterial agent 96 shows toxicity to HepG2 and Vero cells .

HY-B0497C

Niclosamide olamine 25+ Cited Publications BAY2353 olamine	STAT Parasite Antibiotic	Infection Cancer
Niclosamide (BAY2353) olamine is an orally active antihelminthic agent used in parasitic infection research . Niclosamide olamin is a STAT3 inhibitor with an IC₅₀ of 0.25 μM in HeLa cells . Niclosamide olamin has biological activities against cancer, and inhibits DNA replication in Vero E6 cells .

HY-B0497BS

Niclosamide-13C6 monohydrate BAY2353-¹³C₆ monohydrate	STAT Parasite Antibiotic	Cancer
Niclosamide- ¹³C₆ (monohydrate) is the ¹³C labeled Niclosamide monohydrate[1]. Niclosamide (BAY2353) monohydrate is an orally active antihelminthic agent used in parasitic infection research[2]. Niclosamide monohydrate is a STAT3 inhibitor with an IC50 of 0.25 μM in HeLa cells[5]. Niclosamide monohydrate has biological activities against cancer, and inhibits DNA replication in Vero E6 cells[3][4][6].

HY-N3445

Jaceidin triacetate	SARS-CoV	Infection
Jaceidin triacetate(compound 54) is a natural compound isolated formmarulabark.Jaceidin triacetatecan inhibitSARS-CoV-2 Mpro, with theIC₅₀of 11.9μM.Jaceidin triacetateinhibits the replication of Sars-Cov-2 Viral in Vero-E6 cells .

HY-149957

Antileishmanial agent-16	Parasite	Infection
Antileishmanial agent-16 (compound 14c) is an anti-Leishmania agent. Antileishmanial agent-16 has superior anti-Leishmania major promastigotes activity (IC₅₀ = 0.59 µM) and anti-Leishmania major amastigotes activity (IC₅₀ = 0.81 µM). Antileishmanial agent-16 has good safety to mammalian cells (VERO cells) .

HY-156325

SARS-CoV-2-IN-62	SARS-CoV	Infection
SARS-CoV-2-IN-62 (Compound R3b) is an inhibitor of SARS-CoV-2 replication and has low cytotoxicity. SARS-CoV-2-IN-62 inhibits viral replication in Vero E6 cells and Calu-3 cells, with EC₅₀ values of 2.97 μM and 3.82 μM, respectively .

HY-156337

SARS-CoV-2-IN-63	SARS-CoV	Infection
SARS-CoV-2-IN-63 (Compound R3e) is an inhibitor of SARS-CoV-2 replication and has low cytotoxicity. SARS-CoV-2-IN-63 inhibits viral replication in Vero E6 cells and Calu-3 cells, with EC₅₀ values of 1.99 μM and 1.92 μM, respectively .

HY-N10850

Blepharotriol	Bacterial	Cancer
Blepharotriol is a phenolic triterpene that can be found in Maytenus blepharodes. Blepharotriol shows antimicrobial activity with a MIC value of 8-4 µg/ml for Bacillus subtilis. Blepharotriol shows cytotoxic activity with IC₅₀s of 12.2, >20, >20 µM for HeLa, Hep-2, Vero cells, respectively .

HY-169166

HIV-1 protease-IN-14	HIV Protease	Infection
HIV-1 protease-IN-14 (compound 5ae) is a potent HIV-1 protease inhibitor with K_i values of 0.28, 56.9 nM for WT HIV-1 PR, R41T HIV-1 PR, respectively. HIV-1 protease-IN-14 shows low cytotoxicity .

HY-W009245

Bz-RS-iSer(3-Ph)-OMe	HIV	Infection
Bz-RS-iSer(3-Ph)-OMe (compound 2), a Taxol derivative, inhibits HSV replication cycle at low cytotoxicity, blocks mitotic divisions of Vero cells, influences M-MSV induced tumor size and affects immune response by inhibiting PHA-induced T lymphocyte proliferation .

HY-N9351

Cleistanthin B Diphyllin O-glucoside	SARS-CoV	Infection Cardiovascular Disease Metabolic Disease Cancer
Cleistanthin B (Diphyllin O-glucoside) is an orally active arylnaphthalene lignan lactone glycoside. Cleistanthin B exhibits anti-SARS-CoV-2 effects in Vero cells, with EC₅₀ of 6.51 µM. Cleistanthin B also exhibits antitumor, diuretic and antihypertensive effects in vivo .

HY-W011100R

Cyclofenil (Standard)	Dengue virus Estrogen Receptor/ERR Flavivirus	Infection Endocrinology
Cyclofenil (Standard) is the analytical standard of Cyclofenil. This product is intended for research and analytical applications. Cyclofenil is a selective estrogen receptor modulator and an ovulation-inducing agent. Cyclofenil shows an inhibitory effect on dengue virus replication in Vero cells with an EC50 of 1.62 μM. Cyclofenil has anti-dengue-virus activity .

HY-B0497R

Niclosamide (Standard)	STAT Parasite Antibiotic	Infection Cancer
Niclosamide (Standard) is the analytical standard of Niclosamide. This product is intended for research and analytical applications. Niclosamide (BAY2353) is an orally active antihelminthic agent used in parasitic infection research . Niclosamide is a STAT3 inhibitor with an IC₅₀ of 0.25 μM in HeLa cells . Niclosamide has biological activities against cancer, inhibits DNA replication in Vero E6 cells .

HY-118362

Netzahualcoyonol	Bacterial	Infection
Netzahualcoyonol is a quinone methyl triterpene isolated from the roots of Salacia multiflora (Lam.) DC. Netzahualcoyonol exhibits antibacterial and anti-biofilm activities. Netzahualcoyonol inhibits Gram-positive bacteria (MIC=3.26–52 μM). Additionally, Netzahualcoyonol demonstrates cytotoxicity against Hep G2 cells (IC₅₀ = 1.95 μM) but exhibits low toxicity towards Vero cells .

HY-168152

SARS-CoV-2 3CLpro-IN-26	SARS-CoV Virus Protease	Infection
SARS-CoV-2 3CLpro-IN-26 (Compound (S,R)-4y) is an allosteric inhibitor for SARS-CoV-2 3CLpro with an IC₅₀ of 0.43 μM. SARS-CoV-2 3CLpro-IN-26 exhibits good cell permeability and is able to effectively cross the cell membrane, after co-incubation with Vero-E6 cells .

HY-145379

Miaosporone A	Parasite Endogenous Metabolite	Infection
Miaosporone A, an angucyclic quinone, exhibits antimalarial activity against Plasmodium falciparum K1 and antibacterial activity against Mycobacterium tuberculosis with respective IC₅₀ values of 2.5 and 2.4 μM and displays cytotoxic activities against both cancerous (MCF-7 and NCI-H187) and nonmalignant (Vero) cells .

HY-146078

Antimicrobial agent-1	Bacterial	Infection
Antimicrobial agent-1 (compound 6C) possesses potent activity against TolC mutant E. coli with an MIC value of 2 μg/mL. Antimicrobial agent-1 and Colistin exhibit synergistic activity against Gram-negative bacteria. Antimicrobial agent-1 has no cytotoxicity on mammalian cell lines, with MICs > 128 μg/mL in Caco-2 and Vero cell lines .

HY-16952

Bepridil (±)-Bepridil; Org 5730	Calcium Channel Sodium Channel SARS-CoV	Infection Cardiovascular Disease
Bepridil ((±)-Bepridil) is a calcium channel blocking agent used as antiarrhythmic agent. Bepridil inhibits both calcium and sodium currents, has research potential in certain ischemia-induced ventricular arrhythmias. Bepridil also has strong inhibition of SARS-CoV-2 from entry and replication inside Vero E6 and A549 cells .

HY-121763

SCH-43478	HSV	Infection
SCH-43478 is a non-nucleoside antiviral agent. SCH-43478 shows potent and selective activity against herpes simplex virus type 2 (HSV-2) with an IC₅₀ of 1.8 μg/mL using Vero cells. SCH-43478 demonstrates significant efficacy in the guinea pig genital model of HSV infection .

HY-B0497G

Niclosamide BAY2353	Antibiotic Parasite STAT	Cancer
Niclosamide (GMP) is Niclosamide (HY-B0497) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Niclosamide (BAY2353) is an orally active antihelminthic agent used in parasitic infection research . Niclosamide is a STAT3 inhibitor with an IC₅₀ of 0.25 μM in HeLa cells . Niclosamide has biological activities against cancer, inhibits DNA replication in Vero E6 cells .

HY-150554

Antitubercular agent-29	Bacterial	Infection
Antitubercular agent-29 (compound 6xa) is a potent agent resistant (DR) Mycobacterium tuberculosis (Mtb) inhibitor with MIC of 0.03 μg/mL against agent-susceptible (DS)-Mtb strains, MIC of 0.03-0.06 μg/mL against DR-Mtb strains, and favourable selectivity (SI>40) against Vero cells .

HY-162069

Antiviral agent 47	HSV	Infection
Antiviral agent 47 (Compound 26) is an antiviral agent, which inhibits HSV-1 with ID₅₀ of 16 μM, through suppression of herpes virus replication .

HY-161247

5-HT2A antagonist 2	5-HT Receptor	Metabolic Disease
5HT2A antagonist 2 is an orally active, selective antagonist for 5HT_2A with IC₅₀ of 14 nM. 5-HT2A antagonist 2 exhibits good chemical, hepatocyte, and plasma stability, without significant cytotoxicity in cell lines VERO, HFL-1, L929, NIH3T3, CHO-K1 .

HY-162719

RH12	SARS-CoV	Infection
RH12 is a dual inhibitor for SARS-CoV-2 related RNA-dependent RNA polymerase (RdRp, IC₅₀ is 4.42 nM) and human transmembrane serine protease 2 (TMPRSS2, IC₅₀ is 4.2 nM). RH12 exhibits antiviral efficacy. RH12 inhibits viral replication and absorption, and exhibits a 90.5% virucidal effects on Vero-E6 cells. RH12 inhibits cell viability of Calu-3 with an IC₅₀ of 17.5 nM .

HY-151988

SARS-CoV-2-IN-36	SARS-CoV	Infection
SARS-CoV-2-IN-36 is a potent SARS-CoV-2 Mpro (SARS-CoV) inhibitor with an IC₅₀ of 2.37 μM and a K_d of 1.19 μM in enzymatic assays. SARS-CoV-2-IN-36 shows antiviral activity against UC-1074, RG2674, and NVDBB-2220 SARS-CoV-2 variants in Vero cells .

HY-149900

Antiviral agent 33	Biochemical Assay Reagents	Infection
Antiviral agent 33 (compound 1c) is a double-stranded DNA (dsDNA) virus inhibitor with IC₅₀ values of 0.0790 and 0.1572 µM for VACV and AdV5, respectively. Antiviral agent 33 also has potential for oral administration .

HY-149958

Antileishmanial agent-17	Parasite	Infection
Antileishmanial agent-17 is a coumarin hybrid compound with antileishmanial effects (IC₅₀ <0.78 μM). Antileishmanial agent-17 is safe to normal VERO cells. Antileishmanial agent-17 binds to folate pathway enzymes pteridine reductase and DHFR-TS. And Antileishmanial agent-17 shows the most potent with IC₅₀ value of 0.40 μM against promastigote and 0.68 μM against amastigote, respectivley.

HY-155540

SARS-CoV-2 3CLpro-IN-14	SARS-CoV	Infection
SARS-CoV-2 3CLpro-IN-14 (compound 11j) is an orally active SARS-CoV-2 3CLpro inhibitor. SARS-CoV-2 3CLpro-IN-14 shows significant anti-SARS-CoV-2 activity (EC₅₀ = 0.18 μM) and low cytotoxicity (CC₅₀ > 50 μM) in Vero E6 cells .

HY-155981

SARS-CoV-2 3CLpro-IN-18	SARS-CoV	Infection
SARS-CoV-2 3CLpro-IN-18 (Compound 3C) is a covalent SARS-CoV-2 3CLpro inhibitor (IC₅₀s: 0.478 μM). SARS-CoV-2 3CLpro-IN-18 inhibits SARS-CoV-2 in Vero E6 cells (EC₅₀= 2.499 μM) with low cytotoxicity (CC₅₀ > 200 μM) .

Cat. No.	Product Name	Type

HY-B0497G

Niclosamide (GMP)

BAY2353 (GMP)

Fluorescent Dye

Niclosamide (GMP) is Niclosamide (HY-B0497) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Niclosamide (BAY2353) is an orally active antihelminthic agent used in parasitic infection research . Niclosamide is a STAT3 inhibitor with an IC₅₀ of 0.25 μM in HeLa cells . Niclosamide has biological activities against cancer, inhibits DNA replication in Vero E6 cells .

Cat. No.	Product Name	Type

HY-B0497G

Niclosamide (GMP)

BAY2353 (GMP)

Biochemical Assay Reagents

Cat. No.	Product Name	Target	Research Area

HY-P3626

Astodrimer SPL7013 free base	Bacterial HCV SARS-CoV	Infection
Astodrimer (SPL7013 free base) is a large (3-4 nm, ~ 16.5 kDa), negatively charged, highly-branched dendrimer, is a potent virucidal agent. Astodrimer shows antiviral and virucidal activity against a broad spectrum of viruses, including SARS-CoV-2, HIV-1, HSV-1, HSV-2, HPV. Astodrimer also has antibacterial properties .

HY-18234

Leupeptin	Ser/Thr Protease Virus Protease Cathepsin	Infection Inflammation/Immunology
Leupeptin is a broad-spectrum, membrane-permeable protease inhibitor. Leupeptin potently inhibits serine, cysteine and threonine proteases. Leupeptin inhibits M ^pro (the main protease of SARS-CoV-2) and also has anti-inflammatory activity .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N9351

Cleistanthin B Diphyllin O-glucoside	Cardiovascular Disease Infection other families Classification of Application Fields Source classification Lignans Metabolic Disease Phenylpropanoids Plants Disease Research Fields	SARS-CoV
Cleistanthin B (Diphyllin O-glucoside) is an orally active arylnaphthalene lignan lactone glycoside. Cleistanthin B exhibits anti-SARS-CoV-2 effects in Vero cells, with EC₅₀ of 6.51 µM. Cleistanthin B also exhibits antitumor, diuretic and antihypertensive effects in vivo .

HY-N9394

(+)-Norlirioferine	Alkaloids Piperidine Alkaloids Monophenols other families Classification of Application Fields Source classification Other Diseases Phenols Plants Disease Research Fields	Others
(+)-Norlirioferine is an alkaloid compound. (+)-Norlirioferine inhibits the cell growth of macrophages and VERO cells .

HY-N1716

2′′-Acetylastragalin	Structural Classification Flavonoids Flavones Ranunculaceae Source classification Plants Delphinium staphisagria L.	Parasite
2’’-Acetylastragalin (Compound 2) is a compound isolated from the aerial parts of Delphinium staphisagria, with an IC₅₀ value of 6.5 μM for Vero cells. 2’’-Acetylastragalin has trypanoidal activity .

HY-N10351

27-O-(tert-Butyldimethylsilyl)withaferin A	Classification of Application Fields Source classification Withania somnifera Plants Solanaceae Disease Research Fields Steroids Cancer	Apoptosis
27-O-(tert-Butyldimethylsilyl)withaferin A (compound 9a), a natural withanolide, is an apoptosis inducer. 27-O-(tert-Butyldimethylsilyl)withaferin A shows antiproliferative activity against HeLa, A-549 and MCF-7 human cancer cell lines, and against normal Vero cells .

HY-N7302

Anthracophyllone	Structural Classification Microorganisms Terpenoids Sesquiterpenes Source classification	Others
Anthracophyllone is an aristolane sesquiterpene that can be isolated from the mushroom Anthracophyllum. Anthracophyllone has cytotoxicity against MCF-7, KB, NCI-H187, Vero cells (IC₅₀: 32.97, 18.02, 15.17, 18.06 μM) .

HY-N3445

Jaceidin triacetate	Sclerocarya birrea (A.Rich.) Hochst. Structural Classification Flavonoids Flavones Source classification Plants Anacardiaceae	SARS-CoV
Jaceidin triacetate(compound 54) is a natural compound isolated formmarulabark.Jaceidin triacetatecan inhibitSARS-CoV-2 Mpro, with theIC₅₀of 11.9μM.Jaceidin triacetateinhibits the replication of Sars-Cov-2 Viral in Vero-E6 cells .

HY-N10850

Blepharotriol	Triterpenes Structural Classification Terpenoids Source classification Celastraceae Plants	Bacterial
Blepharotriol is a phenolic triterpene that can be found in Maytenus blepharodes. Blepharotriol shows antimicrobial activity with a MIC value of 8-4 µg/ml for Bacillus subtilis. Blepharotriol shows cytotoxic activity with IC₅₀s of 12.2, >20, >20 µM for HeLa, Hep-2, Vero cells, respectively .

HY-145379

Miaosporone A	Infection Quinones Structural Classification Monophenols Classification of Application Fields Anthraquinones Source classification Phenols Endogenous metabolite Disease Research Fields	Parasite Endogenous Metabolite
Miaosporone A, an angucyclic quinone, exhibits antimalarial activity against Plasmodium falciparum K1 and antibacterial activity against Mycobacterium tuberculosis with respective IC₅₀ values of 2.5 and 2.4 μM and displays cytotoxic activities against both cancerous (MCF-7 and NCI-H187) and nonmalignant (Vero) cells .

HY-126640

Phomoxanthone A	Quinones Structural Classification Microorganisms Anthraquinones Source classification	Parasite
Phomoxanthone A is a xanthone dimer, which can be isolated from Phomopsis. Phomoxanthone A exhibits antimalarial and antitubercular activities against Plasmodium falciparum (K1, multidrug-resistant strain, IC₅₀ is 0.11 µg/mL) and Mycobacterium tuberculosis (H37Ra strain, MIC is 0.50 µg/mL). Phomoxanthone A exhibits cytotoxicity in cells KB, BC-1 and Vero, IC₅₀ is 0.99, 0.51 and 1.4 µg/mL, respectively .

HY-N12792

5,8-Dihydroxy-3',4',6,7-tetramethoxyflavone	Structural Classification Flavonoids Euryops arabicus Steud. ex Jaub. & Spach Flavones Source classification Plants Compositae	Others
5,8-Dihydroxy-3',4',6,7-tetramethoxyflavone (Compound 8) is a flavonoid with anticancer activity. 5,8-Dihydroxy-3',4',6,7-tetramethoxyflavone can be isolated from Euryops arabicus .

HY-N12231

Carbazomycin B	Structural Classification Monophenols Microorganisms Source classification Phenols	Antibiotic Bacterial Lipoxygenase
Carbazomycin B is a bacterial metabolite and can be isolated from Streptomyces. Carbazomycin B is an antifungal and antibacterial agent. Carbazomycin B inhibits 5-lipoxygenase (5-LO) activity in extract from RBL-1 cell with the IC₅₀ Of 1.5 µM sup>[2]sup>[3]sup>[4].

HY-N10441

3β-Hydroxy-hop-22(29)-ene	Cnidoscolus spinosus Lundell Triterpenes Terpenoids Source classification Euphorbiaceae Plants	Parasite
3β-Hydroxy-hop-22(29)-ene (compound 3) is a potent antiparasitic agent. 3β-Hydroxy-hop-22(29)-ene shows moderate activity against Trypanosoma cruzi and Leishmania mexicana .

HY-N11650

(22S,24E)-3β,22-Diacetoxylanosta-7,9(11),24-trien-26-oic acid	Triterpenes Structural Classification Microorganisms Terpenoids Source classification	Bacterial
(22S,24E)-3β,22-Diacetoxylanosta-7,9(11),24-trien-26-oic acid (compound 15) is an antitubercular agent with MIC value of 12.5 μg/mL for Mycobacterium tuberculosis H37Ra. (22S,24E)-3β,22-Diacetoxylanosta-7,9(11),24-trien-26-oic acid shows cytotoxicity with IC₅₀ value of 32 μM for Vero cells .

HY-18234A

Leupeptin hemisulfate 35+ Cited Publications	Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Inflammation/Immunology Disease Research Fields	Cathepsin Ser/Thr Protease Virus Protease
Leupeptin hemisulfate is a broad-spectrum, membrane-permeable protease inhibitor. Leupeptin hemisulfate potently inhibits serine, cysteine and threonine proteases. Leupeptin hemisulfate inhibits M ^pro (the main protease of SARS-CoV-2) and also has anti-inflammatory activity .

HY-N2127

Pinostrobin 1 Publications Verification	Structural Classification Monophenols Flavonoids other families Classification of Application Fields Flavonones Source classification Phenols Plants Inflammation/Immunology Disease Research Fields	Amyloid-β Apoptosis Ser/Thr Protease HSV Interleukin Related
Pinostrobin is a flavonoid with anti-cancer, antioxidant, antiviral and neuroprotective activities. Pinostrobin has oral activity. Pinostrobin is a potent PCSK9 inhibitor that inhibits the catalytic activity of PCSK9. Pinostrobin can be used in the research of viral infections, cancer, leukemia, cardiovascular and cerebrovascular diseases, cirrhosis, inflammation and neurological diseases .

Cat. No.	Product Name	Chemical Structure

HY-B0497BS

Niclosamide-13C6 monohydrate

Niclosamide- ¹³C₆ (monohydrate) is the ¹³C labeled Niclosamide monohydrate[1]. Niclosamide (BAY2353) monohydrate is an orally active antihelminthic agent used in parasitic infection research[2]. Niclosamide monohydrate is a STAT3 inhibitor with an IC50 of 0.25 μM in HeLa cells[5]. Niclosamide monohydrate has biological activities against cancer, and inhibits DNA replication in Vero E6 cells[3][4][6].

HY-W653905

Amantadine-d15 hydrochloride

Amantadine-d₁₅ hydrochloride is deuterated labeled Amantadine. Amantadine (1-Adamantanamine) is an orally avtive and potent antiviral agent with activity against influenza A viruses. Amantadine inhibits several ion channels such as NMDA and M2, and also inhibits Coronavirus ion channels. Amantadine also has anti-orthopoxvirus and anticancer activity. Amantadine can be used for Parkinson's disease, postoperative cognitive dysfunction (POCD) and COVID-19 research .

Cat. No.	Product Name		Classification

HY-149058

Neuraminidase-IN-13		Azide
Neuraminidase-IN-13 (Compound 10) is a neuraminidase inhibitor with antiviral activity and low cytotoxicity. Neuraminidase-IN-13 significantly inhibits NDV infection of Vero cells by preventing the release of viral particles from infected cells . Neuraminidase-IN-13 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-168152

SARS-CoV-2 3CLpro-IN-26		Alkynes
SARS-CoV-2 3CLpro-IN-26 (Compound (S,R)-4y) is an allosteric inhibitor for SARS-CoV-2 3CLpro with an IC₅₀ of 0.43 μM. SARS-CoV-2 3CLpro-IN-26 exhibits good cell permeability and is able to effectively cross the cell membrane, after co-incubation with Vero-E6 cells .

HY-149057

Neuraminidase-IN-12		Azide
NDV-IN-1 is an antiviral agent with high neuraminidase inhibitory activity. NDV-IN-1 exhibits in vitro inhibitory activity against Newcastle disease virus (NDV). NDV-IN-1 significantly inhibits NDV infection of Vero cells by preventing the release of virus particles from infected cells . Neuraminidase-IN-12 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

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