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Results for "

alkylating agent

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Cytotoxin (10) Antibiotic (5) Apoptosis (26) Autophagy (7) Bacterial (6) Biochemical Assay Reagents (1) Caspase (1) DNA Alkylator/Crosslinker (73) DNA-PK (1) DNA/RNA Synthesis (4) Drug Metabolite (1) Drug-Linker Conjugates for ADC (6) Endogenous Metabolite (3) Estrogen Receptor/ERR (1) FLAP (1) Isotope-Labeled Compounds (9) MDM-2/p53 (1) NAMPT (1) Necroptosis (1) Nucleoside Antimetabolite/Analog (2)
By Research Areas:	Cancer (102) Infection (4) Inflammation/Immunology (2) Neurological Disease (1)

By Targets:

ADC Cytotoxin (10)

Antibiotic (5)

Apoptosis (26)

Autophagy (7)

Bacterial (6)

Biochemical Assay Reagents (1)

Caspase (1)

DNA Alkylator/Crosslinker (73)

DNA-PK (1)

DNA/RNA Synthesis (4)

Drug Metabolite (1)

Drug-Linker Conjugates for ADC (6)

Endogenous Metabolite (3)

Estrogen Receptor/ERR (1)

FLAP (1)

Isotope-Labeled Compounds (9)

MDM-2/p53 (1)

NAMPT (1)

Necroptosis (1)

Nucleoside Antimetabolite/Analog (2)

By Research Areas:

Cancer (102)

Infection (4)

Inflammation/Immunology (2)

Neurological Disease (1)

107

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0181

Altretamine 2 Publications Verification ENT-50852; RB-1515; WR-95704	DNA Alkylator/Crosslinker	Cancer
Altretamine is an *alkylating* antineoplastic agent.

HY-17576

Satraplatin BMS182751; BMY45594; JM216	DNA Alkylator/Crosslinker	Cancer
Satraplatin is an *alkylating* agent, with potent antitumor effect.

HY-115826

AB-163	Others	Cancer
AB-163 is an alkylating agent with anti-tumor activity. AB-163 exerts LD₅₀s of 198 (p.o.) and 159 (i.p.) mg/kg in ICR/Ha male mice and can be utilized in cancer research .

HY-105815

Chlornaphazine	DNA Alkylator/Crosslinker	Cancer
Chlornaphazine, a nitrogen mustard derivative, is a bifunctional alkylating agent. Chlornaphazine is an antineoplastic agent, which can be used for the study of polycythemia vera and Hodgkin’s disease .

HY-19412

DMS-612 NSC-281612	Others	Cancer
DMS-612 (NSC-281612) is an alkylating agent with anti-renal cell carcinoma activity. DMS-612 can be used in cancer research .

HY-B0078A

Dacarbazine citrate Imidazole Carboxamide citrate	Apoptosis Antibiotic	Cancer
Dacarbazine citrate is a cell cycle nonspecific antineoplastic alkylating agent. Dacarbazine citrate inhibits T and B lymphoblastic response, with IC₅₀ values of 50 and 10 μg/mL, respectively. Dacarbazine Citrate can be used for the research of apoptosis and various cancers such as metastatic malignant melanoma .

HY-127005

Ritrosulfan	DNA Alkylator/Crosslinker	Cancer
Ritrosulfan is a member of the alkylating sugar alcohol. Ritrosulfan is a hydrolyzing alkylating agent with anti-tumor activity .

HY-B0181A

Altretamine hydrochloride ENT-50852 hydrochloride; RB-1515 hydrochloride; WR-95704 hydrochloride	DNA Alkylator/Crosslinker	Cancer
Altretamine hydrochloride is an *alkylating* antineoplastic agent.

HY-B0733

Fotemustine S10036	DNA Alkylator/Crosslinker	Cancer
Fotemustine is a *DNA-alkylating* agent, with antitumor activity.

HY-16325

Miriplatin hydrate SM-11355 hydrate	DNA Alkylator/Crosslinker	Cancer
Miriplatin hydrate (SM-11355 hydrate) is a chemotherapy agent which belongs to the class of *alkylating* agents.

HY-16325A

Miriplatin 3 Publications Verification SM-11355	DNA Alkylator/Crosslinker	Cancer
Miriplatin (SM-11355) is a chemotherapy agent which belongs to the class of *alkylating* agents.

HY-17574

Thio-TEPA 1 Publications Verification	DNA Alkylator/Crosslinker Bacterial Antibiotic	Infection Cancer
Thio-TEPA is a DNA alkylating agent, with antitumor activity.

HY-N0780

Isoalantolactone 4 Publications Verification (+)-Isoalantolactone; Isohelenin	Apoptosis Autophagy Bacterial Endogenous Metabolite	Cancer
Isoalantolactone is an apoptosis inducer, which also acts as an alkylating agent.

HY-17419

Ifosfamide 5+ Cited Publications	DNA Alkylator/Crosslinker	Cancer
Ifosfamide is an *alkylating* chemotherapeutic agent with activity against a wide range of tumors.

HY-13669

Lomustine 5 Publications Verification CCNU; NSC 79037	DNA Alkylator/Crosslinker Autophagy Apoptosis	Cancer
Lomustine (CCNU; NSC 79037) is a DNA alkylating agent, with antitumor activity.

HY-U00155

NCI172112 NSC172112; NSC268497	DNA Alkylator/Crosslinker	Cancer
NCI172112 is a classical bifunctional alkylating agent synthesized in an effort to develop antitumor agents effective against CNS tumors.

HY-17420

Cyclophosphamide 25+ Cited Publications	DNA Alkylator/Crosslinker	Cancer
Cyclophosphamide is a synthetic *alkylating* agent chemically related to the nitrogen mustards with antineoplastic activity, a immunosuppressant.

HY-17420A

Cyclophosphamide hydrate 25+ Cited Publications Cyclophosphamide monohydrate	DNA Alkylator/Crosslinker	Cancer
Cyclophosphamide hydrate is a synthetic *alkylating* agent chemically related to the nitrogen mustards with antineoplastic and immunosuppressive activities.

HY-Y0643

Pivaloyloxymethyl chloride Pivaloyloxymethyl chloride	Biochemical Assay Reagents	Others
Pivaloyloxymethyl chloride can be used as electrolyte solvent for lithium batteries, or used as alkylating agent to improve the biomembrane transport of an agent .

HY-34477

2-Iodoacetamide 2 Publications Verification Iodoacetamide	DNA Alkylator/Crosslinker	Others
2-Iodoacetamide (Iodoacetamide), an alkylating agent, is a commonly used agent for alkylation of cysteine during sample preparation for proteomics .

HY-161051

Anticancer agent 177	NAMPT DNA Alkylator/Crosslinker	Cancer
Anticancer agent 177 (Compound 11b) is a NAMPT inhibitor and DNA alkylating agent. Anticancer agent 177 has antitumor activity in vitro and in vivo .

HY-16513

VAL-083 1 Publications Verification Dianhydrodulcitol; Dianhydrogalactitol	DNA Alkylator/Crosslinker	Cancer
VAL-083 is an *alkylating* agent that creates N7 methylation on DNA, with antitumor activity.

HY-16117A

Brostallicin PNU-166196	Others	Cancer
Brostallicin (PNU-166196) is a DNA alkylating agent with potent cytotoxicity and low myelotoxicity .

HY-136327

Phenylacetic acid mustard	DNA Alkylator/Crosslinker	Cancer
Phenylacetic acid mustard is the major metabolite of the cancer chemotherapeutic agent Chlorambucil (HY-13593). Chlorambucil is an alkylating* agent* with antitumor activity .

HY-16503

Treosulfan 3 Publications Verification NSC 39069; Treosulphan	DNA Alkylator/Crosslinker	Cancer
Treosulfan (NSC 39069) is a bifunctional *alkylating* agent with activity in ovarian cancer and other solid tumor types.

HY-B0181R

Altretamine (Standard)	DNA Alkylator/Crosslinker	Cancer
Altretamine (Standard) is the analytical standard of Altretamine. This product is intended for research and analytical applications. Altretamine is an alkylating antineoplastic agent.

HY-W415824A

Mannomustine dihydrochloride	Others	Cancer
Mannomustine dihydrochloride is an alkylating agent with antineoplastic activity. Mannomustine dihydrochloride causes severe bone marrow depression. Mannomustine dihydrochloride is a powerful vesicant.

HY-128873

Duocarmycin GA	ADC Cytotoxin DNA Alkylator/Crosslinker	Cancer
Duocarmycin GA is an antibody agent conjugates (ADCs) toxin. Duocarmycin is a DNA alkylating agent that binds in the minor groove. Duocarmycin GA can be used against multi-agent resistant cell lines.

HY-107770

Duocarmycin MB	ADC Cytotoxin DNA Alkylator/Crosslinker	Cancer
Duocarmycin MB is an antibody agent conjugates (ADCs) toxin. Duocarmycin is a DNA alkylating agent that binds in the minor groove. Duocarmycin MB can be used against multi-agent resistant cell lines.

HY-18987

Duocarmycin MA	ADC Cytotoxin DNA Alkylator/Crosslinker	Cancer
Duocarmycin MA is an antibody agent conjugates (ADCs) toxin. Duocarmycin is a DNA alkylating agent that binds in the minor groove. Duocarmycin MA can be used against multi-agent resistant cell lines.

HY-13733

Procarbazine Hydrochloride 3 Publications Verification	DNA Alkylator/Crosslinker	Cancer
Procarbazine Hydrochloride is an orally active **alkylating agent**, with anticancer activity. Procarbazine Hydrochloride can be used in Hodgkin's disease research .

HY-16232

GLUFOSFAMIDE D 19575; Glucosylifosfamide mustard	Others	Cancer
Glufosfamide is a novel alkylating agent in which the active metabolite of isophosphoramide mustard is glycosidically linked to β-D-glucose.

HY-13733A

Procarbazine	DNA Alkylator/Crosslinker	Cancer
Procarbazine is an orally active **alkylating agent**, with anticancer activity. Procarbazine can be used in Hodgkin's disease research .

HY-119696

MTIC	Drug Metabolite	Neurological Disease Cancer
MTIC, the active metabolite of Temozolomide (TMZ), is a DNA alkylating agent. MTIC has antitumor activity .

HY-13739

Ranimustine MCNU	DNA Alkylator/Crosslinker	Cancer
Ranimustine (MCNU) is a nitrosourea alkylating agent, can be used for research of chronic myelogenous leukemia and polycythemia vera .

HY-17419A

(R)-Ifosfamide	Others	Cancer
(R)-Ifosfamide is a chemotherapeutic agent primarily used in the treatment of aggressive tumors such as rhabdomyosarcoma, exhibiting alkylating activity that interferes with DNA replication.

HY-114577

Palifosfamide tromethamine Isophosphoramide mustard tromethamine; IPM tromethamine; ZIO-201 tromethamine	DNA Alkylator/Crosslinker	Cancer
Palifosfamide (tromethamine) is a synthetic alkylating agent with potential antineoplastic activity. As the stabilized active metabolite of ifosfamide, palifosfamide (tromethamine) irreversibly alkylates and crosslinks DNA through GC base pairs. This leads to an inhibition of DNA replication and ultimately cell death. Compared to ifosfamide, palifosfamide (tromethamine) is less toxic.

HY-19577

Ambamustine PTT119	DNA Alkylator/Crosslinker	Infection Cancer
Ambamustine (PTT119) is a new bifunctional **alkylating agent** and induces DNA damage by alkylating mechanisms. Ambamustine interferes with late steps in murine mammary tumor virus (MuMTV) processing and maturation and reduces production of the B-type retrovirus MuMTV. Ambamustine possesses cytolytic and antiviral activities .

HY-128957

Vc-seco-DUBA 1 Publications Verification SYD985	Drug-Linker Conjugates for ADC	Cancer
Vc-seco-DUBA (SYD985) is a agent-linker conjugate for ADC with potent antitumor activity by using DUBA (DNA alkylating agent), linked via the ADC linker Vc-seco .

HY-13567S

Bendamustine-d4 SDX-105-d₄ free base	Isotope-Labeled Compounds DNA Alkylator/Crosslinker	Cancer
Bendamustine-d₄ is the deuterium labeled Bendamustine. Bendamustine is a DNA cross-linking agent that causes DNA breaks, with alkylating and antimetabolite properties.

HY-17420S1

Cyclophosphamide-d8	Isotope-Labeled Compounds DNA Alkylator/Crosslinker	Cancer
Cyclophosphamide-d₈ is deuterium labeled Cyclophosphamide. Cyclophosphamide is a synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic activity, a immunosuppressant.

HY-N0780R

Isoalantolactone (Standard)	Apoptosis Autophagy Bacterial Endogenous Metabolite	Cancer
Isoalantolactone (Standard) is the analytical standard of Isoalantolactone. This product is intended for research and analytical applications. Isoalantolactone is an apoptosis inducer, which also acts as an alkylating agent.

HY-136289

MB-VC-MGBA	Drug-Linker Conjugates for ADC	Cancer
MB-VC-MGBA is a agent-linker conjugate for ADC with potent antitumor activity by using MGBA (minor-groove-binding DNA-alkylating agent), linked via the ADC linker MB-VC .

HY-17419S1

Ifosfamide-d4	Isotope-Labeled Compounds DNA Alkylator/Crosslinker	Cancer
Ifosfamide-d₄ is the deuterium labeled Ifosfamide. Ifosfamide is an alkylating chemotherapeutic agent with activity against a wide range of tumors[1][2].

HY-13669R

Lomustine (Standard) CCNU (Standard); NSC 79037 (Standard)	DNA Alkylator/Crosslinker Autophagy Apoptosis	Cancer
Lomustine (Standard) is the analytical standard of Lomustine. This product is intended for research and analytical applications. Lomustine (CCNU; NSC 79037) is a DNA alkylating agent, with antitumor activity.

HY-17419R

Ifosfamide (Standard)	DNA Alkylator/Crosslinker	Cancer
Ifosfamide (Standard) is the analytical standard of Ifosfamide. This product is intended for research and analytical applications. Ifosfamide is an alkylating chemotherapeutic agent with activity against a wide range of tumors.

HY-17574R

Thio-TEPA (Standard)	DNA Alkylator/Crosslinker Bacterial Antibiotic	Infection Cancer
Thio-TEPA (Standard) is the analytical standard of Thio-TEPA. This product is intended for research and analytical applications. Thio-TEPA is a DNA alkylating agent, with antitumor activity.

HY-128880

(+)-CBI-CDPI1	ADC Cytotoxin DNA Alkylator/Crosslinker	Cancer
(+)-CBI-CDPI1 is an enhanced functional analog of CC-1065. (+)-CBI-CDPI1 is a DNA alkylating agent. (+)-CBI-CDPI1 is an antibody agent conjugates (ADCs) toxin.

HY-128881

(+)-CBI-CDPI2	ADC Cytotoxin DNA Alkylator/Crosslinker	Cancer
(+)-CBI-CDPI2 is an enhanced functional analog of CC-1065. (+)-CBI-CDPI1 is a DNA alkylating agent. (+)-CBI-CDPI2 is an antibody agent conjugates (ADCs) toxin.

HY-B0245

Busulfan 10+ Cited Publications	DNA Alkylator/Crosslinker Apoptosis	Inflammation/Immunology Cancer
Busulfan is a potent *alkylating* antineoplastic agent. Busulfan causes DNA damage by cross-linking DNAs and DNA and proteins. Busulfan inhibits thioredoxin reductase. Busulfan induces apoptosis. Busulfan is an immunosuppressive and myeloablative chemotherapeutic agent .

Cat. No.	Product Name

HY-L112

Chemotherapy Drug Library

103 compounds

Chemotherapy is one of the most common treatments for cancer. It can be used alone for some types of cancer or in combination with other treatments such as radiation or surgery. Chemotherapy drugs usually target cells at different phases of the cell cycle and inhibit tumor proliferation and avoid cancer cell invasion and metastasis. It is a cancer treatment method that kills cancer cells with drugs.

Chemotherapeutic agents can be classified into alkylating agents, antimetabolites, antimicrotubular agents, antibiotics, etc. according to the mechanism of action. MCE offers a unique collection of 103 chemotherapy drugs, which is a useful tool for cancer treatment research.

Cat. No.	Product Name	Target	Research Area

HY-105019

Melflufen Melphalan flufenamide	DNA Alkylator/Crosslinker Apoptosis	Cancer
Melflufen (Melphalan flufenamide), a dipeptide proagent of Melphalan, is an alkylating agent. Melflufen shows antitumor activity against multiple myeloma (MM) cells and inhibits angiogenesis. Melflufen induces irreversible DNA damage and cytotoxicity in MM cells .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0780

Isoalantolactone 4 Publications Verification (+)-Isoalantolactone; Isohelenin	Structural Classification Classification of Application Fields Terpenoids Dalbergia velutina Benth. Sesquiterpenes Source classification Plants Compositae Endogenous metabolite Disease Research Fields Cancer	Apoptosis Autophagy Bacterial Endogenous Metabolite
Isoalantolactone is an apoptosis inducer, which also acts as an alkylating agent.

HY-N0780R

Isoalantolactone (Standard)	Structural Classification Terpenoids Dalbergia velutina Benth. Sesquiterpenes Source classification Plants Compositae Endogenous metabolite	Apoptosis Autophagy Bacterial Endogenous Metabolite
Isoalantolactone (Standard) is the analytical standard of Isoalantolactone. This product is intended for research and analytical applications. Isoalantolactone is an apoptosis inducer, which also acts as an alkylating agent.

HY-12457

Rachelmycin CC-1065; NSC 298223	Structural Classification Classification of Application Fields Source classification Disease Research Other Antibiotics Infection Monophenols Microorganisms Antibiotics Phenols Anticancer Disease Research Fields Cancer	Antibiotic DNA/RNA Synthesis
Rachelmycin (CC-1065) is an antitumor antibiotic and a DNA-alkylating agent. Rachelmycin has cytotoxic potency that can be used as a cytotoxin to synthesis ADC. Rachelmycin effectively inhibits DNA synthesis. Rachelmycin can be used for cancer and infection research .

Cat. No.	Product Name	Chemical Structure

HY-34477S1

2-Iodoacetamide-d4
2-Iodoacetamide-d₄ is the deuterium labeled 2-Iodoacetamide[1]. 2-Iodoacetamide (Iodoacetamide), an alkylating agent, is a commonly used agent for alkylation of cysteine during sample preparation for proteomics[2][3].

HY-B0245S

Busulfan-d8
Busulfan-d₈ is a deuterium labeled Busulfan. Busulfan is a potent alkylating antineoplastic agent. Busulfan causes DNA damage by cross-linking DNAs and DNA and proteins. Busulfan inhibits thioredoxin reductase. Busulfan induces apoptosis. Busulfan is an immunosuppressive and myeloablative chemotherapeutic agent[1][2][3].

HY-13567S

Bendamustine-d4
Bendamustine-d₄ is the deuterium labeled Bendamustine. Bendamustine is a DNA cross-linking agent that causes DNA breaks, with alkylating and antimetabolite properties.

HY-17420S1

Cyclophosphamide-d8
Cyclophosphamide-d₈ is deuterium labeled Cyclophosphamide. Cyclophosphamide is a synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic activity, a immunosuppressant.

HY-17419S1

Ifosfamide-d4
Ifosfamide-d₄ is the deuterium labeled Ifosfamide. Ifosfamide is an alkylating chemotherapeutic agent with activity against a wide range of tumors[1][2].

HY-17420S

Cyclophosphamide-d4
Cyclophosphamide-d₄ is the deuterium labeled Cyclophosphamide. Cyclophosphamide is a synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic activity, a immunosuppressant[1][2].

HY-17420AS

Cyclophosphamide-d8 hydrate
Cyclophosphamide-d₈ (hydrate) is the deuterium labeled Cyclophosphamide hydrate. Cyclophosphamide hydrate is a synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic and immunosuppressive activities[1][2].

HY-13593S

Chlorambucil-d8
Chlorambucil-d₈ is the deuterium labeled Chlorambucil. Chlorambucil (CB-1348), an orally active antineoplastic agent, is a bifunctional alkylating agent belonging to the nitrogen mustard group. Chlorambucil can be used for the research of lymphocytic leukemia, ovarian and breast carcinomas, and Hodgkin’s disease[1][2][3][4].

HY-13593S1

Chlorambucil-d8-1
Chlorambucil-d₈-1 is the deuterium labeled Chlorambucil. Chlorambucil (CB-1348), an orally active antineoplastic agent, is a bifunctional alkylating agent belonging to the nitrogen mustard group. Chlorambucil can be used for the research of lymphocytic leukemia, ovarian and breast carcinomas, and Hodgkin’s disease[1][2][3][4].

HY-B0077S1

Bendamustine-d8 hydrochloride
Bendamustine-d₈ (hydrochloride) is deuterium labeled Bendamustine (hydrochloride). Bendamustine hydrochloride (SDX-105), a purine analogue, is a DNA cross-linking agent. Bendamustine hydrochloride activats DNA-damage stress response and apoptosis. Bendamustine hydrochloride has potent alkylating, anticancer and antimetabolite properties[1].

HY-113081S

1-Methyladenosine-d3
1-Methyl Adenosine-d3 is the deuterium labeled 1-Methyladenosine. 1-Methyladenosine is an RNA modification originating essentially from two different reaction types, one catalyzed by enzymes and the other the result of the reaction of RNA with certain alkylating agents.

HY-13567S1

Bendamustine-d8
Bendamustine-d₈ is the deuterium labeled Bendamustine[1]. Bendamustine (SDX-105 free base), a purine analogue, is a DNA cross-linking agent. Bendamustine activates DNA-damage stress response and apoptosis. Bendamustine has potent alkylating, anticancer and antimetabolite properties[2].

HY-17364S

Temozolomide-d3

Temozolomide-d₃ is the deuterium labeled Temozolomide. Temozolomide (NSC 362856) is an oral active DNA alkylating agent that crosses the blood-brain barrier. Temozolomide is also a proautophagic and proapoptotic agent. Temozolomide is effective against tumor cells that are characterized by low levels of O6-alkylguanine DNA alkyltransferase (OGAT) and a functional mismatch repair system. Temozolomide has antitumor and antiangiogenic effects[1][2].

HY-132451S

(R,S)-4-Hydroxy Cyclophosphamide-d4 Preparation Kit
(R,S)-4-Hydroxy Cyclophosphamide-d₄ Preparation Kit is the deuterium labeled (R,S)-4-Hydroxy Cyclophosphamide Preparation Kit. (R,S)-4-Hydroxy Cyclophosphamide is an isomer of 4-Hydroxycyclophosphamide, the active metabolite of the cytotoxic alkylating agent Cyclophosphamide (HY-17420) .

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