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carbonic anhydrase II

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Carbonic Anhydrase (83) Adenosine Receptor (1) Apoptosis (6) Bacterial (2) Calcium Channel (2) CDK (2) Cholinesterase (ChE) (4) COX (2) Dipeptidyl Peptidase (1) Drug Metabolite (1) Endogenous Metabolite (1) Fungal (1) Glucosidase (1) Isotope-Labeled Compounds (3) Phosphatase (1) Phosphodiesterase (PDE) (1) Reactive Oxygen Species (1) Sodium Channel (3)
By Research Areas:	Cancer (39) Cardiovascular Disease (1) Endocrinology (4) Infection (6) Inflammation/Immunology (11) Metabolic Disease (6) Neurological Disease (21)

Inhibitors & Agonists

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Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Carbonic anhydrase inhibitor 2	Carbonic Anhydrase	Endocrinology
Carbonic anhydrase inhibitor 1 (compound 7c) is a carbonic anhydrase II inhibitor. Carbonic anhydrase inhibitor 3 reduces the intraocular pressure in glaucomatous rabbits .

Brinzolamide 3 Publications Verification AL-4862	Carbonic Anhydrase	Others Neurological Disease
Brinzolamide (AL-4862) is a selective carbonic anhydrase II inhibitor with anIC₅₀ value of 3.2 nM. Brinzolamide hydrochloride reduces intraocular pressure (IOP) by inhibiting ciliary CA-II and decreasing atrial fluid secretion. Brinzolamide can be used in glaucoma disease research .

N-Desethyl Brinzolamide oxalate AL-8520 oxalate	Carbonic Anhydrase	Cancer
N-Desethyl Brinzolamide oxalate is a dual inhibitor of Carbonic anhydrase II and Carbonic anhydrase IV with IC₅₀s of 1.28 and 128 nM, respectively .

Carbonic anhydrase inhibitor 3	Carbonic Anhydrase	Endocrinology
Carbonic anhydrase inhibitor 3 (compound 11g) is a carbonic anhydrase II inhibitor. Carbonic anhydrase inhibitor 3 reduces the intraocular pressure in glaucomatous rabbits .

hCAII-IN-6	Carbonic Anhydrase	Endocrinology
hCAII-IN-6 (Compound S-13) is a potent human carbonic anhydrase II (hCA II) inhibitor with a K_i of 4.4 nM. hCAII-IN-6 also inhibits other hCAs isoforms I, IV and IX, with K_i values of 9.2 nM, 480.2 nM and 14.7 nM, respectively. hCAII-IN-6 can be used for glaucoma research .

Brinzolamide hydrochloride AL-4862 hydrochloride	Carbonic Anhydrase	Neurological Disease
Brinzolamide (AL-4862) hydrochloride is a selective carbonic anhydrase II inhibitor with an IC₅₀ value of 3.2 nM. Brinzolamide hydrochloride reduces intraocular pressure (IOP) by inhibiting ciliary CA-II and decreasing atrial fluid secretion. Brinzolamide hydrochloride can be used in glaucoma disease research .

1,3-Dimethyluracil	Endogenous Metabolite	Metabolic Disease
1,3-Dimethyluracil is a pyrimidone derives from a uracil. 1,3-Dimethyluracil found occasionally in human urine. 1,3-Dimethyluracil shows inhibition activity against hCA I and hCA II (human carbonic anhydrase) with K_i of 316.2 μM and 166.4 μM, respectively .

hCAIX/XII-IN-6	Carbonic Anhydrase	Infection
hCAIX/XII-IN-6 is an orally active carbonic anhydrase (CA) inhibitor. hCAIX/XII-IN-6 inhibits human CA isoforms hCA I, II, IV, IX, and XII with K_i values of 6697 nM, 2950 nM, 4093 nM, 4.1 nM and 7.7 nM, respectively. hCAIX/XII-IN-6 can be used for the research of rheumatoid arthritis (RA) .

Carbonic anhydrase inhibitor 15	Carbonic Anhydrase	Neurological Disease Inflammation/Immunology
Carbonic anhydrase inhibitor 15 (Compound 8) is a **carbonic anhydrase inhibitor (K_i*: 8.5 nM for hCA II). Carbonic* anhydrase inhibitor 15 has analgesic effect .

Carbonic anhydrase inhibitor 25	Carbonic Anhydrase	Others
Carbonic anhydrase inhibitor 25 (compound 6a) is a potent **carbonic anhydrase** inhibitor. Carbonic anhydrase inhibitor 25 shows inhibition for hCA I and hCA II receptor .

Carbonic anhydrase inhibitor 20	Carbonic Anhydrase	Cancer
Carbonic anhydrase inhibitor 20 (compound 11) is an inhibitor of piperazinosulfonamide carbonic anhydrase (Carbonic *Anhydrase). The Ki of Carbonic* anhydrase inhibitor 20 for hCA I, hCA II, hCA IX, and hCA XII are 47.6 nM, 36.5 nM, 8.3 nM, and 2.7 nM respectively .

Carbonic anhydrase inhibitor 17	Carbonic Anhydrase	Neurological Disease
Carbonic anhydrase inhibitor 17 (compound 7c) ,pyridazine-tethered sulfonamide, is a carbonic anhydrase II inhibitor with IC₅₀ of 0.63 nM .

Carbonic anhydrase inhibitor 11	Carbonic Anhydrase	Cancer
Carbonic anhydrase inhibitor 11 (compound VI) is a potent, selective carbonic anhydrase inhibitor. Carbonic anhydrase inhibitor 11 shows K_i values of 40, 39, 200 and 900 nM against CA II, IX, and XII, respectively .

Carbonic anhydrase inhibitor 9	Carbonic Anhydrase	Cancer
Carbonic anhydrase inhibitor 9 is a potent carbonic anhydrase (CA) inhibitor with K_is of 56.4 and 56.9 nM for hCA II and IX, respectively. Antiproliferative activity .

Carbonic anhydrase inhibitor 16	Carbonic Anhydrase	Infection
Carbonic anhydrase inhibitor 16 (compound 1) is a dengue protease inhibitor with inhibitory activity against **carbonic anhydrase hCA I and hCA II** (K_i: 28.5 nM, 2.2 nM) .

Carbonic anhydrase inhibitor 23	Carbonic Anhydrase	Infection
Carbonic anhydrase inhibitor 23 (compound 40) is a potent inhibitor of carbonic anhydrase (CA), with the K_i of 617.2 nM and 434.1 nM for hCA I (α) and hCA II (α), respectively .

CAII-IN-1	Carbonic Anhydrase	Cancer
CAII-IN-1 (compound 3n), a thiosemicarbazide derivative, is a potent, selective **carbonic anhydrase-II (CA-II) inhibitor with an IC₅₀** value of 10.3 µM for bovine CA-II. CAII-IN-1 can be used in research of carbonic anhydrase related biological disorders .

CAII-IN-2	Carbonic Anhydrase	Cancer
CAII-IN-2 (compound 3g), a thiosemicarbazide derivative, is a potent, selective **carbonic anhydrase-II (CA-II) inhibitor with an IC₅₀** value of 12.1 µM for bovine CA-II. CAII-IN-2 can be used in research of carbonic anhydrase related biological disorders .

Carbonic anhydrase/AChE-IN-1	Carbonic Anhydrase Cholinesterase (ChE)	Neurological Disease
Carbonic anhydrase/AChE-IN-1 (compound 16) is a **carbonic anhydrase and AChE inhibitor with K_i**s of 24.42 nM, 19.95 nM, and 5.07 nM for hCA I, hCA II, and AChE, respectively .

Carbonic anhydrase inhibitor 14	Carbonic Anhydrase CDK	Cancer
Carbonic anhydrase inhibitor 14 (Compound 8b) is a carbonic anhydrase (CA) inhibitor with K_i values of 1203, 99.7, 9.4 and 27.7 nM against hCA I, hCA II, hCA IX and hCA XII, respectively. Carbonic anhydrase inhibitor 14 can also inhibit CDK2 with an IC₅₀ of 20.3 μM. Carbonic anhydrase inhibitor 14 shows antitumor activity .

Carbonic anhydrase inhibitor 18	Carbonic Anhydrase	Cancer
Carbonic anhydrase inhibitor 18 (Compound 9) is a human carbonic anhydrase (hCA) isoform inhibitor, with K_is of 604.8, 333.6, 1.9 and 6.7 nM for hCA I, hCA II, hCA IX and hCA XII, respectively. Carbonic anhydrase inhibitor 18 can be used for the research of cancer .

Carbonic anhydrase inhibitor 12	Carbonic Anhydrase	Cancer
Carbonic anhydrase inhibitor 12 is a potent CA II inhibitor, also has inhibitory activity in CA I (K_is of 1.72 and 271 nM in CA II and CA I, respectively). Carbonic anhydrase inhibitor 12 has potent anticancer activity against different cancer cell lines .

Carbonic anhydrase inhibitor 5	Carbonic Anhydrase	Infection Inflammation/Immunology Cancer
Carbonic anhydrase inhibitor 5 is a potent and selective *human carbonic* anhydrase (hCA) inhibitor with IC₅₀**s of 42.9, 47,6 and 6.7 nM for hCA II, hCA IX and hCA XII, respectively .

Phenylsulfamide	Carbonic Anhydrase	Others
Phenylsulfamide (Compound 10) is a human carbonic anhydrase-II (hCA-II) inhibitor with a K_d of 45.50 μM and a K_i of 79.60 μM .

*ALP/Carbonic* anhydrase-IN-1**	Carbonic Anhydrase Phosphatase	Inflammation/Immunology
ALP/Carbonic anhydrase-IN-1 (Compound 1e) is a dual carbonic anhydrase (CA) and alkaline phosphatase (ALP) inhibitor. ALP/Carbonic anhydrase-IN-1 shows IC₅₀ values of 0.44 µM, 1.61 µM, 0.51 µM, and 0.107 µM for CA-II, CA-IX, CA-XII, and ALP, respectively .

Methazolamide 2 Publications Verification L584601	Carbonic Anhydrase	Inflammation/Immunology Cancer
Methazolamide (L584601) is a sulfonamide derivative used as a **carbonic anhydrase inhibitor with a K_i** of 14 nM for human carbonic anhydrase II. Methazolamide, an intraocular pressure-lowering agent, reduces intraocular pressure elevations associated with glaucoma and other ocular disorders .

Carbonic anhydrase inhibitor 19	Carbonic Anhydrase	Others
Carbonic anhydrase inhibitor 19 (compound 26a) inhibits the Glaucoma related isoforms hCA II and hCA XII with K_is of 9.4 nM and 6.7 nM, respectively. Carbonic anhydrase inhibitor 19 reveals an intraocular pressure (IOP) lowering effect .

*Enpp/Carbonic* anhydrase-IN-1**	Apoptosis Carbonic Anhydrase Phosphodiesterase (PDE)	Cancer
Enpp/Carbonic anhydrase-IN-1 (compound 1e) is a potent Enpp and **carbonic anhydrase inhibitor with IC₅₀*s of 1.36, 1.35, 3.00, 0.88, 1.02 μM for NPP1, NPP2, NPP3, CA-II, CA-IX respectively. Enpp/Carbonic* anhydrase-IN-1 shows antiproliferative activity for cancer cells and low cytotoxic against normal cells. Enpp/Carbonic anhydrase-IN-1 induces Apoptosis .

Benzenesulphonamide	Carbonic Anhydrase	Cancer
Benzenesulphonamide (compound 1) is a potent **carbonic anhydrase** inhibitor. Benzenesulphonamide shows CA II inhibitory activity .

L-662583	Carbonic Anhydrase	Others
L-662583 is a locally active carbonic anhydrase II inhibitor with an IC₅₀ value of 0.7 nM .

Carbonic anhydrase inhibitor 7	Carbonic Anhydrase	Cancer
Carbonic anhydrase inhibitor 7 (compound 5b) is a potent inhibitor of *human carbonic* anhydrase (hCA), with K_is of 6.5 nM, 7.1 nM, 72.1 nM, and 255.8 nM for hCA IX, hCA II, hCA XII and hCA I**, respectively .

Carbonic anhydrase inhibitor 6	Carbonic Anhydrase	Cancer
Carbonic anhydrase inhibitor 6 (compound 9b) is a potent inhibitor of *human carbonic* anhydrase (hCA), with K_is of 9.7 nM, 35.2 nM, 88.5 nM, and 91.8 nM for hCA IX, hCA II, hCA XII and hCA I**, respectively .

Carbonic anhydrase inhibitor 22	Carbonic Anhydrase	Neurological Disease
Carbonic anhydrase inhibitor 22 (Compd 2g), a sulfonamide **carbonic anhydrase inhibitor, with K_i** values of 762 nM (hCA I), 20.3 nM (hCA II), 8.3 nM (hCA VII), 17.9 nM (hCA IX) and 10.5 nM (hCA XII), repectively .

CAII-IN-3	Carbonic Anhydrase	Cancer
CAII-IN-3 (compound 3h), a thiosemicarbazones derivatives, is a potent carbonic anhydrase-II (CA-II) inhibitor with an IC₅₀ value of 13.4 µM .

4-Acetylphenylboronic acid	Carbonic Anhydrase	Metabolic Disease
4-Acetylphenylboronic acid is a potent inhibitor of carbonic anhydrases II(CA II), with IC₅₀s of 246 μM and 281.40 μM for bovine CA II (bCA II) and human CA II (hCA II), respectively .

hCAI/II-IN-1	Carbonic Anhydrase	Cancer
hCAI/II-IN-1 (Compound 3h) is a *human carbonic* anhydrase I** and II (hCA I/II) inhibitor with IC₅₀ values of 0.047 µM and 0.024 µM against hCA I and hCA II, respectively .

Methazolamide (Standard)	Carbonic Anhydrase	Inflammation/Immunology Cancer
Methazolamide (Standard) is the analytical standard of Methazolamide. This product is intended for research and analytical applications. Methazolamide (L584601) is a sulfonamide derivative used as a **carbonic anhydrase inhibitor with a K_i** of 14 nM for human carbonic anhydrase II. Methazolamide, an intraocular pressure-lowering agent, reduces intraocular pressure elevations associated with glaucoma and other ocular disorders .

hCAII-IN-8	Carbonic Anhydrase	Cancer
hCAII-IN-8, an amide, is a highly selective carbonic anhydrase (CA) inhibitor with an IC₅₀ value of 0.18 μM against hCA II .

hCAI/II-IN-7	Carbonic Anhydrase	Neurological Disease
hCAI/II-IN-7 (compound 1F) is a potent carbonic anhydrase (CA) inhibitor with K_i values of 23 nM, 44 nM and 20.57 µM for hCA-I, hCA-II and bovine CA, respectively .

hCA I-IN-3	Carbonic Anhydrase	Cancer
hCA I-IN-3 (compound 24), an aryl ether derivative, is a potent carbonic anhydrase inhibitor. hCA I-IN-3 can inhibit carbonic anhydrase hCA I and hCA II isoenzymes, with IC₅₀ values of 4.77 and 9.66 nM, respectively. hCA I-IN-3 can be used for cancer research .

Dorzolamide hydrochloride 3 Publications Verification L671152 hydrochloride; MK507 hydrochloride	Carbonic Anhydrase	Others
Dorzolamide (L671152) hydrochloride is a potent carbonic anhydrase II inhibitor, with IC₅₀ values of 0.18 nM and 600 nM for red blood cell CA-II and CA-I respectively. Dorzolamide possesses anti-tumor activity .

Dorzolamide L671152; MK507	Carbonic Anhydrase	Cancer
Dorzolamide (L671152) is a potent carbonic anhydrase II inhibitor, with IC₅₀ values of 0.18 nM and 600 nM for red blood cell CA-II and CA-I respectively. Dorzolamide possesses anti-tumor activity .

O-Desmethyl Brinzolamide hydrochloride	Carbonic Anhydrase Drug Metabolite	Neurological Disease
O-Desmethyl Brinzolamide hydrochloride (compound 6a), an active metabolite of Brinzolamide, is a carbonic anhydrase (CA) inhibitor with a K_d of 0.136 nM for CA II and an IC₅₀ of 165 nM for CA IV .

Halazone	Bacterial Carbonic Anhydrase Sodium Channel	Infection
Halazone is an atypical antimicrobial sulfonamide derivative and a carbonic anhydrase II inhibitor with a K_d value of 1.45 µM. Halazone protects sodium channels from inactivation. Halazone is widely used for disinfection of drinking water .

Species:	Human (4) Mouse (1)
Tag:	His (5)
Source:	HEK293 (3) E. coli (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P72861

	Carbonic Anhydrase 2 Protein, Mouse (His) carbonic anhydrase 2; carbonic anhydrase C; CAC; CA-II; CA2	Mouse	HEK293
	Carbonic Anhydrase 2 Protein is a member of the carbonic anhydrase isozyme family, responsible for catalyzing the reversible hydration of carbon dioxide. Mutations in CA2 are linked to osteopetrosis and renal tubular acidosis. The gene exhibits biased expression in various tissues, notably in the stomach and colon. CA2 plays vital role in the regulation of ion transport and pH balance and is involved in many biological processes. Carbonic Anhydrase 2 Protein, Mouse (His) is the recombinant mouse-derived Carbonic Anhydrase 2 protein, expressed by HEK293 , with C-His labeled tag. The total length of Carbonic Anhydrase 2 Protein, Mouse (His) is 259 a.a., with molecular weight of 30-35 kDa.

HY-P72860

	Carbonic Anhydrase 2 Protein, Human (C-His, Solution) carbonic anhydrase 2; carbonic anhydrase C; CAC; CA-II; CA2	Human	E. coli
	Carbonic Anhydrase 2 (CA2) catalyzes the reversible hydration of carbon dioxide. Mutations in CA2 are linked to osteopetrosis and renal tubular acidosis. The gene exhibits biased expression in various tissues, notably in the stomach and colon. Two transcript variants, encoding different isoforms, have been identified. Carbonic Anhydrase 2 Protein, Human (C-His, Solution) is the recombinant human-derived Carbonic Anhydrase 2 protein, expressed by E. coli , with C-His labeled tag. The total length of Carbonic Anhydrase 2 Protein, Human (C-His, Solution) is 259 a.a., with molecular weight of ~30 kDa.

HY-P72860A

	Carbonic Anhydrase 2 Protein, Human (C-His) carbonic anhydrase 2; carbonic anhydrase C; CAC; CA-II; CA2	Human	E. coli
	Carbonic Anhydrase 2 (CA2) catalyzes the reversible hydration of carbon dioxide. Mutations in CA2 are linked to osteopetrosis and renal tubular acidosis. The gene exhibits biased expression in various tissues, notably in the stomach and colon. Two transcript variants, encoding different isoforms, have been identified. Carbonic Anhydrase 2 Protein, Human (C-His) is the recombinant human-derived Carbonic Anhydrase 2 protein, expressed by E. coli , with C-6*His labeled tag.

HY-P7729

	Carbonic Anhydrase 11 Protein, Human (HEK293, His) rHucarbonic anhydrase 11, His; carbonic anhydrase-Related Protein 11; CARP XI; carbonic anhydrase-Related Protein 2; CA-RP II; CA11; CARP2	Human	HEK293
	Carbonic Anhydrase 11 Protein, Human (HEK293, His) is an approximately 38.0 kDa carbonic anhydrase 11 protein with a His-flag. Carbonic anhydrases (CAs) are found in many organisms, in which they contribute to several important biological processes.

HY-P78746

	Carbonic Anhydrase 2 Protein, Human (HEK293, His) CA2; CA-II; CAII; Car2	Human	HEK293
	Carbonic Anhydrase 2 (CA2) catalyzes the reversible hydration of carbon dioxide. Mutations in CA2 are linked to osteopetrosis and renal tubular acidosis. The gene exhibits biased expression in various tissues, notably in the stomach and colon. Two transcript variants, encoding different isoforms, have been identified. Carbonic Anhydrase 2 Protein, Human (HEK293, His) is the recombinant human-derived Carbonic Anhydrase 2 protein, expressed by HEK293 , with C-His labeled tag. The total length of Carbonic Anhydrase 2 Protein, Human (HEK293, His) is 260 a.a., with molecular weight of approximately 31.72 kDa.

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Cat. No.	Product Name	Chemical Structure

HY-B0124S

Zonisamide-d4
Zonisamide-d₄ is the deuterium labeled Zonisamide. Zonisamide (AD 810) is an inhibitor of zinc enzyme carbonic anhydrase (CA), with Kis of 35.2 nM and 20.6 nM for human mitochondrial isozyme hCA II and hCA V, respectively. Zonisamide has antiepileptic activity. Zonisamide can be used for the rsearch for epilepsy, seizures and Parkinson's disease[1][2].

HY-B0553S

Methazolamide-d6
Methazolamide-d₆ is the deuterium labeled Methazolamide. Methazolamide (L584601) is a sulfonamide derivative used as a carbonic anhydrase inhibitor with a Ki of 14 nM for human carbonic anhydrase II. Methazolamide, an intraocular pressure-lowering agent, reduces intraocular pressure elevations associated with glaucoma and other ocular disorders[1][2].

HY-B0588S

Brinzolamide-d5
Brinzolamide-d₅ is the deuterium labeled Brinzolamide. Brinzolamide (AL 4862) is a potent carbonic anhydrase II inhibitor with IC50 of 3.19 nM.

HY-B0109S

Dorzolamide-d5
Dorzolamide-d₅ is the deuterium labeled Dorzolamide. Dorzolamide (L671152) is a potent carbonic anhydrase II inhibitor, with IC50 values of 0.18 nM and 600 nM for red blood cell CA-II and CA-I respectively. Dorzolamide possesses anti-tumor activity[1][2].

HY-B0109AS

Dorzolamide-d3 hydrochloride
Dorzolamide-d₃ hydrochloride is deuterated labeled Dorzolamide hydrochloride (HY-B0109A). Dorzolamide (L671152) hydrochloride is a potent carbonic anhydrase II inhibitor, with IC₅₀ values of 0.18 nM and 600 nM for red blood cell CA-II and CA-I respectively. Dorzolamide possesses anti-tumor activity .

HY-B0588AS

Brinzolamide-d5 hydrochloride

Brinzolamide-d₅ (hydrochloride) is the deuterium labeled Brinzolamide hydrochloride[1]. Brinzolamide (AL-4862) hydrochloride is a selective carbonic anhydrase II inhibitor with an IC50 value of 3.2 nM. Brinzolamide hydrochloride reduces intraocular pressure (IOP) by inhibiting ciliary CA-II and decreasing atrial fluid secretion. Brinzolamide hydrochloride can be used in glaucoma disease research[2][3].

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P83617

	Carbonic Anhydrase 2 Antibody (YA3362) CA2; carbonic anhydrase 2; Carbonate dehydratase II; carbonic anhydrase C; CAC; carbonic anhydrase II; CA-II	WB, IHC-P	Human, Mouse, Rat
	Carbonic Anhydrase 2 Antibody (YA3362) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3362), targeting Carbonic Anhydrase 2, with a predicted molecular weight of 29 kDa (observed band size: 29 kDa). Carbonic Anhydrase 2 Antibody (YA3362) can be used for WB, IHC-P experiment in human, mouse, rat background.

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