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Chondroitin sulfate sodium (from shark cartilage), one of five classes of glycosaminoglycans, has been widely used in the treatment of osteoarthritis. Chondroitin sulfate reduces inflammation mediators and the apoptotic process and is able to reduce protein production of inflammatory cytokines, iNOS and MMPs .
Highly purified Type II collagen, from bovine articular cartilage (Bovine Type II collagen, immunization grade), an immunization grade, is the major matrix protein in cartilage that can be used for the study of arthritis .
ADAMTS-5-IN-3 (Example 37-2) is a potent inhibitor of ADAMTS-5 and ADAMTS-4 with IC50s of 8 and 12 nM, respectively. ADAMTS-5-IN-3 can be used for the research of diseases involving degradation of cartilage or disruption of cartilage homeostasis, in particular osteoarthrosis and/or rheumatoid arthritis .
SGK1-IN-3 hydrochloride (compound 3a) is a potent and orally active inhibitor of SGK1. The serine/threonine kinase SGK1 is an activator of the β-catenin pathway and a powerful stimulator of cartilage degradation that is found to be upregulated under genomic control in diseased osteoarthritic cartilage. SGK1-IN-3 hydrochloride has the potential for the research of osteoarthritis .
Chondroitin sulfate (from shark cartilage) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
WYRGRL, a collagen II-targeting peptide, can bind to collagen II α1. WYRGRL is a short cartilage-targeting peptide sequence. WYRGRL leads to about 72-fold increase of cartilage-targeting efficiency for the peptide-functionalized nanoplatform in vivo .
Pivalylbenzhydrazine (Pivhydrazine) is a potent monoamine oxidase (MAO) inhibitor. Pivalylbenzhydrazine decreases cartilage growth in normal rats. Pivalylbenzhydrazine can be used in research of depression .
SGK1-IN-3 (compound 3a) is a potent and orally active inhibitor of SGK1. The serine/threonine kinase SGK1 is an activator of the β-catenin pathway and a powerful stimulator of cartilage degradation that is found to be upregulated under genomic control in diseased osteoarthritic cartilage. SGK1-IN-3 has the potential for the research of osteoarthritis .
Highly purified Type II collagen, from porcine articular cartilage (Porcine Type II collagen, immunization grade) is an immune grade collagen derived from porcine articular cartilage, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .
Highly purified Type XI collagen, from porcine articular cartilage (Porcine Type XI collagen, immunization grade) is an immune grade collagen derived from porcine articular cartilage, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .
Highly purified Type II collagen, from chick sternal cartilage (Chick Type II collagen, immunization grade) is an immune grade collagen derived from chick sternal cartilage, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .
Highly purified Type IX collagen, from bovine articular cartilage (Bovine Type IX collagen, immunization grade) is an immune grade collagen derived from bovine articular cartilage, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .
Highly purified type II collagen, from rat sternal cartilage (Rat Type II collagen, immunization grade) is an immune grade collagen derived from rat sternal cartilage, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .
Highly purified Type II collagen, from mouse sternal cartilage (Mouse Type II collagen, immunization grade) is an immune grade collagen derived from mouse sternal cartilage, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .
Highly purified Type IX collagen, from chick articular cartilage (Chick Type IX collagen, immunization grade) is an immune grade collagen derived from chick articular cartilage, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .
Highly purified Type XI collagen, from human sternal cartilage (Human Type XI collagen, immunization grade) is an immune grade collagen derived from human sternal cartilage, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .
Highly purified Type IX collagen, from porcine articular cartilage (Porcine Type IX collagen, immunization grade) is an immune grade collagen derived from porcine articular cartilage, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .
Highly purified Type II collagen, from sheep articular cartilage (Sheep Type II collagen, immunization grade) is an immune grade collagen derived from sheep articular cartilage, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .
Highly purified Type II collagen, from goat articular cartilage (Goat Type II collagen, immunization grade) is an immune grade collagen derived from goat articular cartilage, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .
Highly purified Type II collagen, from human sternal cartilage (Human Type II collagen, immunization grade) is an immune grade collagen derived from human sternal cartilage, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .
Highly purified Type XI collagen, from bovine articular cartilage (Bovine Type XI collagen, immunization grade) is an immune grade collagen derived from bovine articular cartilage, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .
Highly purified Type XI collagen, from chick articular cartilage (Chick Type XI collagen, immunization grade) is an immune grade collagen derived from chick articular cartilage, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .
Ioxaglic acid (P-286) is negatively charged contrast agent, is useful as an inverse indicator for glycosaminoglycan (GAG) used in computed tomography (CT). Ioxaglic acid can be used for imaging of human osteoarthritic cartilage via quantitative assessment of glycosaminoglycan content .
Ocrylate is a tissue adhesive that contains an 8-carbon alkyl cyanoacrylate in its structure. Ocrylate can be used in research on gastric fundal varices, bone and cartilage grafting, cerebrospinal fluid leakage repair, and skin closure. Additionally, the rapid polymerization property of Ocrylate makes it suitable for inhibiting vascular embolization .
Anti-inflammatory agent 21 (compound 9o) is an orally active and low cytotoxic anti-inflammatory agent, with an IC50 value of 0.76 μM for NO. Anti-inflammatory agent 21 acts via accumulation ROS and blocks the NF-κB/MAPK signaling pathway. Anti-inflammatory agent 21 can ameliorate cartilage destruction and inflammatory cell infiltration in arthritis rats model .
Pamidronic acid, the second-generation nitrogen-containing bisphosphonate, is an inhibitor of bone loss. Pamidronic acid significantly inhibits subchondral bone loss in early osteoarthritis by upregulating the expression of OPG in cartilage and subchondral bone, and inhibiting the expression of RANKL and MMP-9 in both tissues, as well as TLR-4 in cartilage, thereby alleviating cartilage degeneration. Additionally, Pamidronic acid can inhibit the signaling of Wnt and β-catenin, and is applicable for research on osteoporosis and osteosarcoma .
Pamidronic acid sodium, the second-generation nitrogen-containing bisphosphonate, is an inhibitor of bone loss. Pamidronic acid sodium significantly inhibits subchondral bone loss in early osteoarthritis by upregulating the expression of OPG in cartilage and subchondral bone, and inhibiting the expression of RANKL and MMP-9 in both tissues, as well as TLR-4 in cartilage, thereby alleviating cartilage degeneration. Additionally, Pamidronic acid sodium can inhibit the signaling of Wnt and β-catenin, and is applicable for research on osteoporosis and osteosarcoma .
Glucosamine (D-Glucosamine) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids, is used as a dietary supplement. Glucosamine also is a natural constituent of glycosaminoglycans in the cartilage matrix and synovial fluid, which when administered exogenously, exerts pharmacological effects on osteoarthritic cartilage and chondrocytes .
Glucosamine hydrochloride (D-Glucosamine hydrochloride) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids, is used as a dietary supplement. Glucosamine hydrochloride also is a natural constituent of glycosaminoglycans in the cartilage matrix and synovial fluid, which when administered exogenously, exerts pharmacological effects on osteoarthritic cartilage and chondrocytes .
Pamidronate disodium, the second-generation nitrogen-containing bisphosphonate, is an inhibitor of bone loss. Pamidronate disodium significantly inhibits subchondral bone loss in early osteoarthritis by upregulating the expression of OPG in cartilage and subchondral bone, and inhibiting the expression of RANKL and MMP-9 in both tissues, as well as TLR-4 in cartilage, thereby alleviating cartilage degeneration. Additionally, Pamidronate disodium can inhibit the signaling of Wnt and β-catenin, and is applicable for research on osteoporosis and osteosarcoma .
Glucosamine sulfate (D-Glucosamine sulfate) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids, is used as a dietary supplement. Glucosamine sulfate also is a natural constituent of glycosaminoglycans in the cartilage matrix and synovial fluid, which when administered exogenously, exerts pharmacological effects on osteoarthritic cartilage and chondrocytes .
Ginsenoside F4 (GF4), ginseng saponinis, isolated from notoginseng or red ginseng. Ginsenoside F4 (GF4) has inhibitory effect on human lymphocytoma JK cell by inducing its apoptosis .
Ginsenoside F4 (GF4) inhibits matrix metalloproteinase 13 (MMP 13) expression in IL-1β-treated chondrocytes and blocks cartilage breakdown in rabbit cartilage tissue culture, shows therapeutic potential for preventing cartilage collagen matrix breakdown in diseased tissues .
Pamidronate disodium (Standard) is the analytical standard of Pamidronate disodium.Pamidronate disodium (Standard), the second-generation nitrogen-containing bisphosphonate, is an inhibitor of bone loss. Pamidronate disodium (Standard) significantly inhibits subchondral bone loss in early osteoarthritis by upregulating the expression of OPG in cartilage and subchondral bone, and inhibiting the expression of RANKL and MMP-9 in both tissues, as well as TLR-4 in cartilage, thereby alleviating cartilage degeneration. Additionally, Pamidronate disodium (Standard) can inhibit the signaling of Wnt and β-catenin, and is applicable for research on osteoporosis and osteosarcoma .
Glucosamine (hydrochloride) (Standard) is the analytical standard of Glucosamine (hydrochloride). This product is intended for research and analytical applications. Glucosamine hydrochloride (D-Glucosamine hydrochloride) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids, is used as a dietary supplement. Glucosamine hydrochloride also is a natural constituent of glycosaminoglycans in the cartilage matrix and synovial fluid, which when administered exogenously, exerts pharmacological effects on osteoarthritic cartilage and chondrocytes .
Fructosamine hydrochloride (D-Isoglucosamine hydrochloride) is a metabolic intermediate and component of cell membranes and cartilage. Fructosamine hydrochloride induces site-specific breaks in DNA chains, especially in the presence of Cu 2+ .
CGS 27023A is a non-peptidic and orally active MMP inhibitor with the Ki values of 43, 33, 20 and 8 nM for MMP-3, MMP-1, MMP-2 amd MMP-9, respectively. CGS 27023A can be used for study of arthritis .
3′-Phosphoadenosine 5′-phosphosulfate tetralithium salt (PAPS tetralithium salt) is the cosubstrate and the source of sulfonic acid groups in sulfation reactions. 3′-Phosphoadenosine 5′-phosphosulfate tetralithium salt is important for maintaining sulfation balance in living organisms .
T26c sodium is a potent and selective MMP13 inhibitor with IC50 value of 6.9 pM. T26c sodium can inhibit the degradation of bovine nasal septal cartilage explants .
Collagen, Type I, from bovine achilles tendon are extracellular matrix proteins and show many applications in food, cosmetic, pharmaceutical and biomedical industries. Collagens play an important role in the structure and function of skin, cartilage, bone and connective tissue .
Isecarosmab (M-6495) is an anti-ADAMTS monoclonal antibody (mAb) with a KD value of 3.65 pM. Isecarosmab has chondroprotective and anti-inflammatory activities. Isecarosmab can bind albumin to extend plasma half-life .
Kartogenin (KGN) is an inducer of chondrogenic tissue formation (EC50: 100 nM). Kartogenin induces chondrogenesis by binding to fibrin A, disrupting its interaction with the transcription factor core binding factor beta subunit (CBFβ), and by modulating the CBFβ-RUNX1 transcriptional program. Kartogenin also promotes tendon-bone junction (TBJ) wound healing by stimulating collagen synthesis. Kartogenin is widely used in cell-free therapy in the field of regeneration for cartilage regeneration and protection, tendon-bone healing, wound healing and limb development. Kartogenin promotes cartilage repair, coordinates limb development, and is also used in osteoarthritis (OA) research .
Kartogenin (KGN) sodium is an inducer of chondrogenic tissue formation (EC50: 100 nM). Kartogenin sodium induces chondrogenesis by binding to fibrin A, disrupting its interaction with the transcription factor core binding factor beta subunit (CBFβ), and by modulating the CBFβ-RUNX1 transcriptional program. Kartogenin sodium also promotes tendon-bone junction (TBJ) wound healing by stimulating collagen synthesis. Kartogenin sodium is widely used in cell-free therapy in the field of regeneration for cartilage regeneration and protection, tendon-bone healing, wound healing and limb development. Kartogenin sodium promotes cartilage repair, coordinates limb development, and is also used in osteoarthritis (OA) research .
ADAMTS-5 Inhibitor is a potent ADAMTS-5 (aggrecanase-2) inhibitor, with an IC50 of 1.1 µM. ADAMTS-5 Inhibitor shows >40-fold functional selectivity over ADAMTS-4 (aggrecanase-1) .
MDL 101146 is an orally active neutrophil elastase inhibitor. MDL 101146 inhibits neutrophil elastase for human with a Ki value of 25 nM. MDL 101146 can be used for the research of arthritis .
Cynaropicrin is a sesquiterpene lactone which can inhibit tumor necrosis factor (TNF-α) release with IC50s of 8.24 and 3.18 μM for murine and human macrophage cells, respectively. Cynaropicrin also inhibits the increase of cartilage degradation factor (MMP13) and suppresses NF-κB signaling.
Triamcinolone acetonide inhibits basic fibroblast growth factor (bFGF) induced proliferation of retinal endothelial cells. Triamcinolone acetonide reduces chondrocyte viability and leads to cartilage destruction. Triamcinolone acetonide activates macrophage with anti-inflammatory characteristics. Triamcinolone acetonide can be used in the study of diseases such as atopic dermatitis .
Δ14-Triamcinolone acetonide is a potential impurity. Triamcinolone acetonide inhibits basic fibroblast growth factor (bFGF) induced proliferation of retinal endothelial cells. Triamcinolone acetonide reduces chondrocyte viability and leads to cartilage destruction. Triamcinolone acetonide can be used in the study of diseases such as atopic dermatitis .
Cynaropicrin (Standard) is the analytical standard of Cynaropicrin. This product is intended for research and analytical applications. Cynaropicrin is a sesquiterpene lactone which can inhibit tumor necrosis factor (TNF-α) release with IC50s of 8.24 and 3.18 μM for murine and human macrophage cells, respectively. Cynaropicrin also inhibits the increase of cartilage degradation factor (MMP13) and suppresses NF-κB signaling.
Enpp-1-IN-21 (compound 4g) is an inhibitor of ecto-nucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1), with IC50 values for ENPP1 and ENPP3 at 0.45 and 0.19 μM, respectively .
Golimumab (CNTO-148) is a potent human IgG1 TNFα antagonist monoclonal antibody. Golimumab has anti-inflammation activitity and inhibits IL-6 and IL-1β production. Golimumab acts via targeting and neutralizing TNF to prevent inflammation and destruction of cartilage and bone. Golimumab has the anticancer activity and induces cell apoptosis. Golimumab can be used for rheumatoid arthritis, Crohn's disease and cancer research .
Collagenase, Type VI (EC 3.4.24.3) is a collagenase that can degrade type VI collagen. Type VI collagen is a component of cell membranes in various tissues (such as skin, heart, blood vessels, cartilage, and synovial fluid). Excessive collagenase can cause extracellular matrix lesions. Collagenase is also a biomarker for tumor invasion and metastasis. Collagenase, Type VI can specifically act on the peptide bond between proline and glycine. This feature can be used to quickly and sensitively detect its concentration level in experiments using corresponding modified electrodes .
MMP13-IN-2 is a potent, selective and orally active MMP-13 inhibitor. MMP13-IN-2 exhibits excellent potency for MMP-13 (IC50=0.036 nM) and selectivities (greater than 1,500-fold) over MMP-1, 3, 7, 8, 9, 14, and TACE. MMP13-IN-2 has the ability to block the release of collagen from cartilage in vitro. MMP13-IN-2 has the potential for collagenase related disease research .
SD-7300 (SC-81490) is an orally active inhibitor of MMP-2, MMP-9, and MMP-13 with Ki values ??of 0.03, 0.01, and 0.03 nM, respectively. SD-7300 can reduce the degradation of extracellular matrix by tumor cells, thereby inhibiting the invasion and metastasis of tumor cells. In addition, SD-7300 is also a dose-dependent inhibitor of mouse corneal angiogenesis and an inhibitor of interleukin-1-induced bovine cartilage degradation. SD-7300 can be used in breast cancer research .
CMC2.24 (TRB-N0224), an orally active tricarbonylmethane agent, is effective against pancreatic tumor in mice by inhibiting Ras activation and its downstream effector ERK1/2 pathway. CMC2.24 is also a potent inhibitor of zinc-dependent MMPs with IC50s ranging from 2.0-69 μM. CMC2.24 alleviates osteoarthritis progression by restoring cartilage homeostasis and inhibiting chondrocyte apoptosis via the NF-κB/HIF-2α axis .
Red Fluorescent Gelatin Methacryloyl (Red Fluorescent GelMA) is methacryloyl gelatin (GelMA) with red fluorescence, which is obtained by "grafting" fluorescent molecules on GelMA. Red Fluorescent Gelatin Methacryloyl acts as a scaffold and can be used to engineer tissue analogs from the vasculature to cartilage and bone, allowing cells to proliferate and spread . GelMA, 30% methacrylation, Red Fluorescent needs to self-assemble into fibrous hydrogel under the action of photoinitiator LAP (HY-44076), and target bioactive adhesion sites, play an inherent supporting role for tissue cells and biodegradable activity. Application: cell culture, biological 3D printing, tissue engineering, etc.
Green Fluorescent Gelatin Methacryloyl (Green Fluorescent GelMA) is methacryloyl gelatin (GelMA) with green fluorescence, which is obtained by "grafting" fluorescent molecules on GelMA. Green Fluorescent Gelatin Methacryloyl acts as a scaffold and can be used to engineer tissue analogs from the vasculature to cartilage and bone, allowing cells to proliferate and spread . GelMA, 30% methacrylation, Green Fluorescent needs to self-assemble into fibrous hydrogel under the action of photoinitiator LAP (HY-44076), and target bioactive adhesion sites, play an inherent supporting role for tissue cells and biodegradable activity. Application: cell culture, biological 3D printing, tissue engineering, etc.
Red Fluorescent Gelatin Methacryloyl (Red Fluorescent GelMA) is methacryloyl gelatin (GelMA) with red fluorescence, which is obtained by "grafting" fluorescent molecules on GelMA. Red Fluorescent Gelatin Methacryloyl acts as a scaffold and can be used to engineer tissue analogs from the vasculature to cartilage and bone, allowing cells to proliferate and spread . GelMA, 90% methacrylation, Red Fluorescent needs to self-assemble into fibrous hydrogel under the action of photoinitiator LAP (HY-44076), and target bioactive adhesion sites, play an inherent supporting role for tissue cells and biodegradable activity. Application: cell culture, biological 3D printing, tissue engineering, etc.
Red Fluorescent Gelatin Methacryloyl (Red Fluorescent GelMA) is methacryloyl gelatin (GelMA) with red fluorescence, which is obtained by "grafting" fluorescent molecules on GelMA. Red Fluorescent Gelatin Methacryloyl acts as a scaffold and can be used to engineer tissue analogs from the vasculature to cartilage and bone, allowing cells to proliferate and spread . GelMA, 60% methacrylation, Red Fluorescent needs to self-assemble into fibrous hydrogel under the action of photoinitiator LAP (HY-44076), and target bioactive adhesion sites, play an inherent supporting role for tissue cells and biodegradable activity. Application: cell culture, biological 3D printing, tissue engineering, etc.
Green Fluorescent Gelatin Methacryloyl (Green Fluorescent GelMA) is methacryloyl gelatin (GelMA) with green fluorescence, which is obtained by "grafting" fluorescent molecules on GelMA. Green Fluorescent Gelatin Methacryloyl acts as a scaffold and can be used to engineer tissue analogs from the vasculature to cartilage and bone, allowing cells to proliferate and spread . GelMA, 60% methacrylation, Green Fluorescent needs to self-assemble into fibrous hydrogel under the action of photoinitiator LAP (HY-44076), and target bioactive adhesion sites, play an inherent supporting role for tissue cells and biodegradable activity. Application: cell culture, biological 3D printing, tissue engineering, etc.
Green Fluorescent Gelatin Methacryloyl (Green Fluorescent GelMA) is methacryloyl gelatin (GelMA) with green fluorescence, which is obtained by "grafting" fluorescent molecules on GelMA. Green Fluorescent Gelatin Methacryloyl acts as a scaffold and can be used to engineer tissue analogs from the vasculature to cartilage and bone, allowing cells to proliferate and spread . GelMA, 90% methacrylation, Green Fluorescent needs to self-assemble into fibrous hydrogel under the action of photoinitiator LAP (HY-44076), and target bioactive adhesion sites, play an inherent supporting role for tissue cells and biodegradable activity. Application: cell culture, biological 3D printing, tissue engineering, etc.
Toluidine blue (ZnCl2) is a basic thiazine dye commonly used as a biological stain for microscopy. It has a deep bluish-purple color and is commonly used to stain nucleic acids such as DNA and RNA, as well as to stain mast cells, cartilage, and other connective tissues. Toluidine blue (ZnCl2) stains the acidic components of these tissues, such as sulfated or carboxylated mucopolysaccharides. It is frequently used in histology, cytology, and pathology applications to aid in the diagnosis of various diseases and conditions. The dye is usually applied to tissue sections prior to microscopic examination and can be differentiated using an acidic alcohol solution. Toluidine blue (ZnCl2) is a relatively simple and inexpensive stain with good reproducibility, making it a popular choice for many laboratories.
Gelatin Methacryloyl (GelMA), 30% methacrylation, blue fluorescent is methacrylated gelatin (GelMA) with blue fluorescence, which is obtained by "grafting" fluorescent molecules on GelMA. Gelatin Methacryloyl, 30% methacrylation, blue fluorescent has a scaffolding effect and can be used to design tissue analogs from vasculature to cartilage and bone, allowing cell proliferation and spreading. Gelatin Methacryloyl, 30% methacrylation, blue fluorescent needs to be self-assembled into fibrous hydrogels under the action of the photoinitiator LAP (HY-44076), and target bioactive adhesion sites, exert inherent support for tissue cells and biodegradation activity. Application direction: cell culture, biological 3D printing, tissue engineering, etc.
Gelatin Methacryloyl (GelMA), 90% methacrylation, blue fluorescent is methacrylated gelatin (GelMA) with blue fluorescence, which is obtained by "grafting" fluorescent molecules on GelMA. Gelatin Methacryloyl, 90% methacrylation, blue fluorescent has a scaffolding effect and can be used to design tissue analogs from vasculature to cartilage and bone, allowing cell proliferation and spreading. Gelatin Methacryloyl, 30% methacrylation, blue fluorescent needs to be self-assembled into fibrous hydrogels under the action of the photoinitiator LAP (HY-44076), and target bioactive adhesion sites, exert inherent support for tissue cells and biodegradation activity. Application direction: cell culture, biological 3D printing, tissue engineering, etc.
Gelatin Methacryloyl (GelMA), 60% methacrylation, blue fluorescent is methacrylated gelatin (GelMA) with blue fluorescence, which is obtained by "grafting" fluorescent molecules on GelMA. Gelatin Methacryloyl, 60% methacrylation, blue fluorescent has a scaffolding effect and can be used to design tissue analogs from vasculature to cartilage and bone, allowing cell proliferation and spreading. Gelatin Methacryloyl, 30% methacrylation, blue fluorescent needs to be self-assembled into fibrous hydrogels under the action of the photoinitiator LAP (HY-44076), and target bioactive adhesion sites, exert inherent support for tissue cells and biodegradation activity. Application direction: cell culture, biological 3D printing, tissue engineering, etc.
Toluidine blue (ZnCl2) is a basic thiazine dye commonly used as a biological stain for microscopy. It has a deep bluish-purple color and is commonly used to stain nucleic acids such as DNA and RNA, as well as to stain mast cells, cartilage, and other connective tissues. Toluidine blue (ZnCl2) stains the acidic components of these tissues, such as sulfated or carboxylated mucopolysaccharides. It is frequently used in histology, cytology, and pathology applications to aid in the diagnosis of various diseases and conditions. The dye is usually applied to tissue sections prior to microscopic examination and can be differentiated using an acidic alcohol solution. Toluidine blue (ZnCl2) is a relatively simple and inexpensive stain with good reproducibility, making it a popular choice for many laboratories.
Highly purified Type II collagen, from bovine articular cartilage (Bovine Type II collagen, immunization grade), an immunization grade, is the major matrix protein in cartilage that can be used for the study of arthritis .
Highly purified Type II collagen, from chick sternal cartilage (Chick Type II collagen, immunization grade) is an immune grade collagen derived from chick sternal cartilage, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .
Chondroitin sulfate (from shark cartilage) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
Highly purified Type II collagen, from porcine articular cartilage (Porcine Type II collagen, immunization grade) is an immune grade collagen derived from porcine articular cartilage, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .
Highly purified Type XI collagen, from porcine articular cartilage (Porcine Type XI collagen, immunization grade) is an immune grade collagen derived from porcine articular cartilage, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .
Highly purified Type IX collagen, from bovine articular cartilage (Bovine Type IX collagen, immunization grade) is an immune grade collagen derived from bovine articular cartilage, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .
Highly purified type II collagen, from rat sternal cartilage (Rat Type II collagen, immunization grade) is an immune grade collagen derived from rat sternal cartilage, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .
Highly purified Type II collagen, from mouse sternal cartilage (Mouse Type II collagen, immunization grade) is an immune grade collagen derived from mouse sternal cartilage, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .
Highly purified Type IX collagen, from chick articular cartilage (Chick Type IX collagen, immunization grade) is an immune grade collagen derived from chick articular cartilage, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .
Highly purified Type XI collagen, from human sternal cartilage (Human Type XI collagen, immunization grade) is an immune grade collagen derived from human sternal cartilage, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .
Highly purified Type IX collagen, from porcine articular cartilage (Porcine Type IX collagen, immunization grade) is an immune grade collagen derived from porcine articular cartilage, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .
Highly purified Type II collagen, from sheep articular cartilage (Sheep Type II collagen, immunization grade) is an immune grade collagen derived from sheep articular cartilage, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .
Highly purified Type II collagen, from goat articular cartilage (Goat Type II collagen, immunization grade) is an immune grade collagen derived from goat articular cartilage, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .
Highly purified Type II collagen, from human sternal cartilage (Human Type II collagen, immunization grade) is an immune grade collagen derived from human sternal cartilage, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .
Highly purified Type XI collagen, from bovine articular cartilage (Bovine Type XI collagen, immunization grade) is an immune grade collagen derived from bovine articular cartilage, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .
Highly purified Type XI collagen, from chick articular cartilage (Chick Type XI collagen, immunization grade) is an immune grade collagen derived from chick articular cartilage, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .
Collagen, Type I, from bovine achilles tendon are extracellular matrix proteins and show many applications in food, cosmetic, pharmaceutical and biomedical industries. Collagens play an important role in the structure and function of skin, cartilage, bone and connective tissue .
Red Fluorescent Gelatin Methacryloyl (Red Fluorescent GelMA) is methacryloyl gelatin (GelMA) with red fluorescence, which is obtained by "grafting" fluorescent molecules on GelMA. Red Fluorescent Gelatin Methacryloyl acts as a scaffold and can be used to engineer tissue analogs from the vasculature to cartilage and bone, allowing cells to proliferate and spread . GelMA, 30% methacrylation, Red Fluorescent needs to self-assemble into fibrous hydrogel under the action of photoinitiator LAP (HY-44076), and target bioactive adhesion sites, play an inherent supporting role for tissue cells and biodegradable activity. Application: cell culture, biological 3D printing, tissue engineering, etc.
Green Fluorescent Gelatin Methacryloyl (Green Fluorescent GelMA) is methacryloyl gelatin (GelMA) with green fluorescence, which is obtained by "grafting" fluorescent molecules on GelMA. Green Fluorescent Gelatin Methacryloyl acts as a scaffold and can be used to engineer tissue analogs from the vasculature to cartilage and bone, allowing cells to proliferate and spread . GelMA, 30% methacrylation, Green Fluorescent needs to self-assemble into fibrous hydrogel under the action of photoinitiator LAP (HY-44076), and target bioactive adhesion sites, play an inherent supporting role for tissue cells and biodegradable activity. Application: cell culture, biological 3D printing, tissue engineering, etc.
Red Fluorescent Gelatin Methacryloyl (Red Fluorescent GelMA) is methacryloyl gelatin (GelMA) with red fluorescence, which is obtained by "grafting" fluorescent molecules on GelMA. Red Fluorescent Gelatin Methacryloyl acts as a scaffold and can be used to engineer tissue analogs from the vasculature to cartilage and bone, allowing cells to proliferate and spread . GelMA, 90% methacrylation, Red Fluorescent needs to self-assemble into fibrous hydrogel under the action of photoinitiator LAP (HY-44076), and target bioactive adhesion sites, play an inherent supporting role for tissue cells and biodegradable activity. Application: cell culture, biological 3D printing, tissue engineering, etc.
Red Fluorescent Gelatin Methacryloyl (Red Fluorescent GelMA) is methacryloyl gelatin (GelMA) with red fluorescence, which is obtained by "grafting" fluorescent molecules on GelMA. Red Fluorescent Gelatin Methacryloyl acts as a scaffold and can be used to engineer tissue analogs from the vasculature to cartilage and bone, allowing cells to proliferate and spread . GelMA, 60% methacrylation, Red Fluorescent needs to self-assemble into fibrous hydrogel under the action of photoinitiator LAP (HY-44076), and target bioactive adhesion sites, play an inherent supporting role for tissue cells and biodegradable activity. Application: cell culture, biological 3D printing, tissue engineering, etc.
Green Fluorescent Gelatin Methacryloyl (Green Fluorescent GelMA) is methacryloyl gelatin (GelMA) with green fluorescence, which is obtained by "grafting" fluorescent molecules on GelMA. Green Fluorescent Gelatin Methacryloyl acts as a scaffold and can be used to engineer tissue analogs from the vasculature to cartilage and bone, allowing cells to proliferate and spread . GelMA, 60% methacrylation, Green Fluorescent needs to self-assemble into fibrous hydrogel under the action of photoinitiator LAP (HY-44076), and target bioactive adhesion sites, play an inherent supporting role for tissue cells and biodegradable activity. Application: cell culture, biological 3D printing, tissue engineering, etc.
Green Fluorescent Gelatin Methacryloyl (Green Fluorescent GelMA) is methacryloyl gelatin (GelMA) with green fluorescence, which is obtained by "grafting" fluorescent molecules on GelMA. Green Fluorescent Gelatin Methacryloyl acts as a scaffold and can be used to engineer tissue analogs from the vasculature to cartilage and bone, allowing cells to proliferate and spread . GelMA, 90% methacrylation, Green Fluorescent needs to self-assemble into fibrous hydrogel under the action of photoinitiator LAP (HY-44076), and target bioactive adhesion sites, play an inherent supporting role for tissue cells and biodegradable activity. Application: cell culture, biological 3D printing, tissue engineering, etc.
Gelatin Methacryloyl (GelMA), 30% methacrylation, blue fluorescent is methacrylated gelatin (GelMA) with blue fluorescence, which is obtained by "grafting" fluorescent molecules on GelMA. Gelatin Methacryloyl, 30% methacrylation, blue fluorescent has a scaffolding effect and can be used to design tissue analogs from vasculature to cartilage and bone, allowing cell proliferation and spreading. Gelatin Methacryloyl, 30% methacrylation, blue fluorescent needs to be self-assembled into fibrous hydrogels under the action of the photoinitiator LAP (HY-44076), and target bioactive adhesion sites, exert inherent support for tissue cells and biodegradation activity. Application direction: cell culture, biological 3D printing, tissue engineering, etc.
Gelatin Methacryloyl (GelMA), 90% methacrylation, blue fluorescent is methacrylated gelatin (GelMA) with blue fluorescence, which is obtained by "grafting" fluorescent molecules on GelMA. Gelatin Methacryloyl, 90% methacrylation, blue fluorescent has a scaffolding effect and can be used to design tissue analogs from vasculature to cartilage and bone, allowing cell proliferation and spreading. Gelatin Methacryloyl, 30% methacrylation, blue fluorescent needs to be self-assembled into fibrous hydrogels under the action of the photoinitiator LAP (HY-44076), and target bioactive adhesion sites, exert inherent support for tissue cells and biodegradation activity. Application direction: cell culture, biological 3D printing, tissue engineering, etc.
Gelatin Methacryloyl (GelMA), 60% methacrylation, blue fluorescent is methacrylated gelatin (GelMA) with blue fluorescence, which is obtained by "grafting" fluorescent molecules on GelMA. Gelatin Methacryloyl, 60% methacrylation, blue fluorescent has a scaffolding effect and can be used to design tissue analogs from vasculature to cartilage and bone, allowing cell proliferation and spreading. Gelatin Methacryloyl, 30% methacrylation, blue fluorescent needs to be self-assembled into fibrous hydrogels under the action of the photoinitiator LAP (HY-44076), and target bioactive adhesion sites, exert inherent support for tissue cells and biodegradation activity. Application direction: cell culture, biological 3D printing, tissue engineering, etc.
KLD-12 is a 12-residue self-assembling peptide that is used in tissue-engineering. KLD-12 combined with SDF-1 self-assembled polypeptide enhances chondrogenic differentiation of bone marrow stromal cells (BMSCs). KLD-12 hydrogel can fill full-thickness osteochondral defects in situ and improve cartilage repair .
WAAG-3R TFA is a biological active peptide. (Aggrecanases belong to the ADAMTS (A disintegrin and metalloprotease with thrombospondin motif) family of proteases. Aggrecanases cleave aggrecan, the major structural component of cartilage. Aggrecanase-1 (ADAMTS-4) is a major aggrecanase in human osteoarthritic cartilage. This FRET peptide was used in an ADAMTS-4 (Aggrecanase-1) and ADAMTS-5 (Aggrecanase-2) assay . (Ex/Em = 340/420 nm)
G4RGDSP, Integrin-binding peptide is a cell integrin-binding peptide that targets integrin receptors. G4RGDSP, integrin-binding peptide is coupled to alginate to increase the viability of cells in the scaffold. G4RGDSP, integrin-binding peptide can be used as an extrudable carrier for chondrocyte delivery for the study of 3D printing technology
KLD-12 TFA is the TFA salt form of KLD-12 (HY-P2263). KLD-12 TFA is a self a 12-residue self-assembling peptide that is used in tissue-engineering. KLD-12 TFA combined with SDF-1 self-assembled polypeptide enhances chondrogenic differentiation of bone marrow stromal cells (BMSCs). KLD-12 TFA hydrogel can fill full-thickness osteochondral defects in situ and improve cartilage repair .
WYRGRL, a collagen II-targeting peptide, can bind to collagen II α1. WYRGRL is a short cartilage-targeting peptide sequence. WYRGRL leads to about 72-fold increase of cartilage-targeting efficiency for the peptide-functionalized nanoplatform in vivo .
WAAG-3R is a biological active peptide. (Aggrecanases belong to the ADAMTS (A disintegrin and metalloprotease with thrombospondin motif) family of proteases. Aggrecanases cleave aggrecan, the major structural component of cartilage. Aggrecanase-1 (ADAMTS-4) is a major aggrecanase in human osteoarthritic cartilage. This FRET peptide was used in an ADAMTS-4 (Aggrecanase-1) and ADAMTS-5 (Aggrecanase-2) assay . (Ex/Em = 340/420 nm)
Isecarosmab (M-6495) is an anti-ADAMTS monoclonal antibody (mAb) with a KD value of 3.65 pM. Isecarosmab has chondroprotective and anti-inflammatory activities. Isecarosmab can bind albumin to extend plasma half-life .
Golimumab (CNTO-148) is a potent human IgG1 TNFα antagonist monoclonal antibody. Golimumab has anti-inflammation activitity and inhibits IL-6 and IL-1β production. Golimumab acts via targeting and neutralizing TNF to prevent inflammation and destruction of cartilage and bone. Golimumab has the anticancer activity and induces cell apoptosis. Golimumab can be used for rheumatoid arthritis, Crohn's disease and cancer research .
Chondroitin sulfate sodium (from shark cartilage), one of five classes of glycosaminoglycans, has been widely used in the treatment of osteoarthritis. Chondroitin sulfate reduces inflammation mediators and the apoptotic process and is able to reduce protein production of inflammatory cytokines, iNOS and MMPs .
Glucosamine (D-Glucosamine) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids, is used as a dietary supplement. Glucosamine also is a natural constituent of glycosaminoglycans in the cartilage matrix and synovial fluid, which when administered exogenously, exerts pharmacological effects on osteoarthritic cartilage and chondrocytes .
Glucosamine hydrochloride (D-Glucosamine hydrochloride) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids, is used as a dietary supplement. Glucosamine hydrochloride also is a natural constituent of glycosaminoglycans in the cartilage matrix and synovial fluid, which when administered exogenously, exerts pharmacological effects on osteoarthritic cartilage and chondrocytes .
Glucosamine sulfate (D-Glucosamine sulfate) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids, is used as a dietary supplement. Glucosamine sulfate also is a natural constituent of glycosaminoglycans in the cartilage matrix and synovial fluid, which when administered exogenously, exerts pharmacological effects on osteoarthritic cartilage and chondrocytes .
Ginsenoside F4 (GF4), ginseng saponinis, isolated from notoginseng or red ginseng. Ginsenoside F4 (GF4) has inhibitory effect on human lymphocytoma JK cell by inducing its apoptosis .
Ginsenoside F4 (GF4) inhibits matrix metalloproteinase 13 (MMP 13) expression in IL-1β-treated chondrocytes and blocks cartilage breakdown in rabbit cartilage tissue culture, shows therapeutic potential for preventing cartilage collagen matrix breakdown in diseased tissues .
Glucosamine (hydrochloride) (Standard) is the analytical standard of Glucosamine (hydrochloride). This product is intended for research and analytical applications. Glucosamine hydrochloride (D-Glucosamine hydrochloride) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids, is used as a dietary supplement. Glucosamine hydrochloride also is a natural constituent of glycosaminoglycans in the cartilage matrix and synovial fluid, which when administered exogenously, exerts pharmacological effects on osteoarthritic cartilage and chondrocytes .
Cynaropicrin is a sesquiterpene lactone which can inhibit tumor necrosis factor (TNF-α) release with IC50s of 8.24 and 3.18 μM for murine and human macrophage cells, respectively. Cynaropicrin also inhibits the increase of cartilage degradation factor (MMP13) and suppresses NF-κB signaling.
Cynaropicrin (Standard) is the analytical standard of Cynaropicrin. This product is intended for research and analytical applications. Cynaropicrin is a sesquiterpene lactone which can inhibit tumor necrosis factor (TNF-α) release with IC50s of 8.24 and 3.18 μM for murine and human macrophage cells, respectively. Cynaropicrin also inhibits the increase of cartilage degradation factor (MMP13) and suppresses NF-κB signaling.
The COMP protein is critical for cartilage integrity and interacts with extracellular matrix proteins to promote the connection of chondrocytes to the cartilage matrix through integrin receptors. Its role in the pathogenesis of osteoarthritis emphasizes the significance of joint health. COMP Protein, Human (HEK293, His) is the recombinant human-derived COMP protein, expressed by HEK293 , with C-His labeled tag. The total length of COMP Protein, Human (HEK293, His) is 737 a.a., with molecular weight of 120-130 kDa.
TGFB1 proprotein is the precursor of latency-associated peptide (LAP) and active transforming growth factor Beta-1 (TGF-β-1) chain, which maintains TGF-β-1 latency in the extracellular matrix. TGFB1 binds non-covalently to TGF-β-1 and regulates its activation through interactions with “environmental molecules” (LTBP1, LRRC32/GARP, LRRC33/NRROS). Animal-Free TGF beta 1/TGFB1 Protein, Pig (His) is the recombinant pig-derived animal-FreeTGF beta 1/TGFB1 protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free TGF beta 1/TGFB1 Protein, Pig (His) is 112 a.a., with molecular weight of ~13.7 kDa.
The GDF-5 protein is critical in bone and cartilage formation, complexly regulating chondrogenic tissue differentiation through dual pathways. It positively affects cartilage formation by inducing SMAD protein signaling by binding to BMPR1B and BMPR1A. Animal-Free GDF-5 Protein, Human (His) is the recombinant human-derived animal-FreeGDF-5 protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free GDF-5 Protein, Human (His) is 120 a.a., with molecular weight of ~14.52 kDa.
HAPLN1 protein is vital in stabilizing proteoglycan monomer aggregates in cartilage's extracellular matrix. Through interaction with hyaluronic acid, it ensures structural integrity and stability, facilitating proteoglycan binding and organization. HAPLN1's role is crucial for maintaining the extracellular environment, providing proper support and resilience in cartilage tissues. HAPLN1 Protein, Human (HEK293, His) is the recombinant human-derived HAPLN1 protein, expressed by HEK293 , with C-His labeled tag. The total length of HAPLN1 Protein, Human (HEK293, His) is 339 a.a., with molecular weight of ~52 KDa.
The CHI3L1 protein is a binding lectin that lacks chitinase activity. CHI3L1 contributes to tissue remodeling, cellular adaptation to environmental changes, and T helper type 2 inflammatory responses. CHI3L1 also controls hyperoxia-induced injury, inflammation, and epithelial cell apoptosis. Animal-Free CHI3L1 Protein, Human (His) is the recombinant human-derived animal-FreeCHI3L1 protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free CHI3L1 Protein, Human (His) is 362 a.a., with molecular weight of ~41.43 kDa.
The CHI3L1 protein is a binding lectin that lacks chitinase activity. CHI3L1 contributes to tissue remodeling, cellular adaptation to environmental changes, and T helper type 2 inflammatory responses. CHI3L1 also controls hyperoxia-induced injury, inflammation, and epithelial cell apoptosis. CHI3L1 Protein, Human (HEK293, His) is the recombinant human-derived CHI3L1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of CHI3L1 Protein, Human (HEK293, His) is 362 a.a., with molecular weight of 41-48 kDa.
UCMA proteins are key regulators of the complex control of osteogenic differentiation, particularly in the fetal cartilage periphery and at the cartilage-bone interface. Its involvement suggests a crucial role in negatively regulating osteochondral precursor cell differentiation. UCMA Protein, Human is the recombinant human-derived UCMA protein, expressed by E. coli , with tag free. The total length of UCMA Protein, Human is 74 a.a., with molecular weight of ~14.0 kDa.
CLEC3A protein plays a key role in promoting cell adhesion to laminin and fibronectin, indicating its crucial function in mediating cellular interactions with the extracellular matrix. This ability underscores its importance in regulating cell attachment, spreading, and signaling behaviors, contributing to the intricate network of molecular interactions governing cell-matrix interactions. CLEC3A Protein, Mouse (sf9, His) is the recombinant mouse-derived CLEC3A protein, expressed by Sf9 insect cells , with C-His labeled tag.
ACAN Antibody is an unconjugated, rabbit-derived, anti-ACAN monoclonal antibody. ACAN Antibody can be used for:IHC-P expriments in human background without labeling.
Collagen II alpha 1; COL2A1; COL2A1 protein; collagen, type II, alpha 1; collagen alpha-1(II); type II collagen; alpha-1 type II collagen; alpha1 type II collagen; Col2a1; AOM; cartilage collagen; Chondrocalcin; COL11A3; Collagen alpha 1(II) chain precursor; Collagen II alpha 1 polypeptide; Collagen type II alpha 1 (primary osteoarthritis spondyloepiphyseal dysplasia congenital); MGC131516; SEDC; Collagen alpha-1(II) chain; Alpha-1 type II collagen; CO2A1_HUMAN.; CollagenII;
WB, ELISA, IHC-P, ICC/IF
Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit, Guinea Pig
Collagen II Antibody is an unconjugated, approximately 117 KDa, rabbit-derived, anti-Collagen II polyclonal antibody. Collagen II Antibody can be used for: WB, ELISA, IHC-P, IF expriments in human, mouse, rat, chicken, dog, pig, cow, rabbit, guinea pig background without labeling.
Hyaluronan and proteoglycan link protein 1; cartilage-linking protein 1; cartilage-link protein; Proteoglycan link protein; HAPLN1; CRTL1
WB, IHC-P, ICC/IF
Human, Mouse, Rat
HAPLN1 Antibody (YA2805) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2805), targeting HAPLN1, with a predicted molecular weight of 40 kDa (observed band size: 48 kDa). HAPLN1 Antibody (YA2805) can be used for WB, IHC-P, ICC/IF experiment in human, mouse, rat background.
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