Search Result

Results for "

caspases-1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Caspase (56) Adenosine Receptor (1) AIM2 (2) Akt (1) Angiotensin-converting Enzyme (ACE) (1) Antibiotic (4) Apoptosis (12) Bacterial (4) Bcl-2 Family (1) Biochemical Assay Reagents (1) Cathepsin (2) Checkpoint Kinase (Chk) (1) Cholinesterase (ChE) (1) COX (3) DNA/RNA Synthesis (1) Drug Metabolite (1) Endogenous Metabolite (3) Fluorescent Dye (3) Glutathione Peroxidase (1) GPR55 (2) HIF/HIF Prolyl-Hydroxylase (1) HIV (1) IFNAR (2) Influenza Virus (1) Integrin (2) Interleukin Related (18) Isotope-Labeled Compounds (1) Lactate Dehydrogenase (1) MDM-2/p53 (1) MicroRNA (1) Mitochondrial Metabolism (1) Neurokinin Receptor (1) NF-κB (4) NOD-like Receptor (NLR) (13) PARP (2) PI3K (1) Potassium Channel (3) Pyroptosis (9) Reactive Oxygen Species (3) RIP kinase (1) SARS-CoV (1) TNF Receptor (3) Tyrosinase (3) VEGFR (1) Wnt (3) β-catenin (3)
By Research Areas:	Cancer (30) Cardiovascular Disease (2) Infection (10) Inflammation/Immunology (48) Metabolic Disease (1) Neurological Disease (11)

By Targets:

Caspase (56)

Adenosine Receptor (1)

AIM2 (2)

Akt (1)

Angiotensin-converting Enzyme (ACE) (1)

Antibiotic (4)

Apoptosis (12)

Bacterial (4)

Bcl-2 Family (1)

Biochemical Assay Reagents (1)

Cathepsin (2)

Checkpoint Kinase (Chk) (1)

Cholinesterase (ChE) (1)

COX (3)

DNA/RNA Synthesis (1)

Drug Metabolite (1)

Endogenous Metabolite (3)

Fluorescent Dye (3)

Glutathione Peroxidase (1)

GPR55 (2)

HIF/HIF Prolyl-Hydroxylase (1)

HIV (1)

IFNAR (2)

Influenza Virus (1)

Integrin (2)

Interleukin Related (18)

Isotope-Labeled Compounds (1)

Lactate Dehydrogenase (1)

MDM-2/p53 (1)

MicroRNA (1)

Mitochondrial Metabolism (1)

Neurokinin Receptor (1)

NF-κB (4)

NOD-like Receptor (NLR) (13)

PARP (2)

PI3K (1)

Potassium Channel (3)

Pyroptosis (9)

Reactive Oxygen Species (3)

RIP kinase (1)

SARS-CoV (1)

TNF Receptor (3)

Tyrosinase (3)

VEGFR (1)

Wnt (3)

β-catenin (3)

By Research Areas:

Cancer (30)

Cardiovascular Disease (2)

Infection (10)

Inflammation/Immunology (48)

Metabolic Disease (1)

Neurological Disease (11)

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Peptides

MCE Kits

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Caspase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-111675

Ac-FLTD-CMK 5+ Cited Publications	Caspase Pyroptosis	Inflammation/Immunology
Ac-FLTD-CMK, a gasdermin D (GSDMD)-derived inhibitor, is a specific inflammatory caspases inhibitor. Ac-FLTD-CMK is effective against *caspases-1* (IC₅₀ of 46.7 nM), *caspases-4* (IC₅₀ of 1.49 μM), *caspases-5* (IC₅₀ of 329 nM), and *caspases-11* , but not the apoptotic caspases such as caspase-3 ^[1].

HY-P2091

Ac-YVAD-pNA	Caspase	Inflammation/Immunology
Ac-YVAD-pNA is a specific *Caspase-1* substrate. Ac-YVAD-pNA can be used to detect Caspase-1 activity. Caspase-1 is a key mediator of inflammatory processes ^[1] .

HY-P2617A

Ac-WEHD-AFC TFA	Caspase	Inflammation/Immunology Cancer
Ac-WEHD-AFC TFA is a *fluorogenic caspase-1* substrate*. Ac-WEHD-AFC TFA can measure caspase-1* fluorogenic activity and can be used for the research of tumor and inflammation ^[1].

HY-P4547

Ac-Trp-Glu-His-Asp-AMC AC-WEHD-AMC	Caspase	Others
Ac-Trp-Glu-His-Asp-AMC (AC-WEHD-AMC) is a potent fluorogenic substrate of caspase-1 ^[1].

HY-P10084

Ac-VAD-pNA	Caspase	Others
Ac-VAD-pNA is a *caspase-1* substrate. Ac-VAD-pNA can be used to detect caspase-1 activity ^[1].

HY-P2617

Ac-WEHD-AFC	Caspase	Inflammation/Immunology Cancer
Ac-WEHD-AFC is a *fluorogenic caspase-1* substrate*. Ac-WEHD-AFC can measure caspase-1* fluorogenic activity and can be used for the research of tumor and inflammation ^[1].

HY-136728

Ac-YVAD-AOM	Caspase	Cancer
Ac-YVAD-AOM is the inhibitor of *caspase*-1 that shows antitumor activity ^[1].

HY-W792412

Z-YVAD-CMK	Caspase	Cancer
Z-YVAD-CMK is a *caspase-1* and *caspase-3* inhibitor ^[1].

HY-P5974

Z-YVAD-pNA Z-Tyr-Val-Ala-Asp-pNA	Caspase	Others
Z-YVAD-pNA (Z-Tyr-Val-Ala-Asp-pNA) is a *caspase-1* substrate ^[1].

HY-P5938

Ac-AAVALLPAVLLALLAP-YVAD-CHO	Caspase	Cancer
Ac-AAVALLPAVLLALLAP-YVAD-CHO is a cell-permeable *caspase*-1 inhibitor that has antitumor activity ^[1].

HY-P2377

Ac-YVAD-AFC 4 Publications Verification	Fluorescent Dye	Others
Ac-YVAD-AFC is the the fluorometric peptide substrate of caspase-1, with λ excitation of 400 nm and λ emission of 505 nm ^[1] .

HY-P2616

Mca-YVADAP-Lys(Dnp)-OH	Caspase Angiotensin-converting Enzyme (ACE)	Others
Mca-YVADAP-Lys(Dnp)-OH is a fluorogenic substrate for *caspase-1* and angiotensin-converting enzyme 2 (ACE2) ^[1].

HY-P4535

Ac-Trp-Glu-His-Asp-Aldehyde	Caspase	Inflammation/Immunology
Ac-Trp-Glu-His-Asp-Aldehyde is a potent and selective *caspase-1* inhibitor with a K_i value of 56 pM ^[1] .

HY-16990

Ac-YVAD-cmk 10+ Cited Publications Caspase-1 Inhibitor II	Caspase	Inflammation/Immunology
Ac-YVAD-cmk (Caspase-1 Inhibitor II) is a selective *caspase-1* (IL-1beta converting enzyme, ICE)) inhibitor with neuroprotective and anti-inflammatory effects. Ac-YVAD-cmk effectively suppresses the expression of IL-1β and IL-18. Ac-YVAD-cmk inhibits pyroptosis in many diseases ^[1] .

HY-P2616A

Mca-YVADAP-Lys(Dnp)-OH TFA	Cholinesterase (ChE) Caspase	Others
Mca-YVADAP-Lys(Dnp)-OH TFA is a fluorogenic substrate for caspase-1 and angiotensin-converting enzyme 2 (ACE2) ^[1].

HY-153068

CZL55	Caspase	Inflammation/Immunology
CZL55 is a *caspase-1* inhibitor with an IC₅₀ value of 24 nM. CZL55 can be used for the research of febrile seizures (FS) ^[1].

HY-W075517

ZIF-8 2-Methylimidazole zinc salt	Caspase Pyroptosis	Cancer
ZIF-8 is an anticancer agent that intrinsically induces pyroptosis through a caspase-1/gasdermin D (GSDMD)-dependent pathway ^[1].

HY-131204

CZL80	Caspase	Neurological Disease
CZL80, a brain-penetrable *caspase-1* inhibitor with an IC₅₀ of 0.01 μM, could be used in the study of febrile seizures and later enhanced epileptogenic susceptibility ^[1].

HY-156415

NLRP3 agonist 2	NOD-like Receptor (NLR)	Inflammation/Immunology
NLRP3 agonist 2 (compound 22) is a orally active NLRP3 agonist.NLRP3 agonist 2 activates *Caspase-1* in THP1 cells ^[1].

HY-P5122

Z-LEED-FMK	Caspase	Inflammation/Immunology
Z-LEED-FMK is a *caspase-13* and *caspase-4* inhibitor. Z-LEED-FMK also inhibits caspase-1 processing in S. typhimurium-infected macrophages ^[1] .

HY-P3761

Ac-Tyr-Val-Lys-Asp-aldehyde	Caspase	Others
Ac-Tyr-Val-Lys-Asp-aldehyde is a *caspase-1* inhibitor, can be used for disease research including anemia-associated to chronic diseases, chemotherapy-induced anemia and Diamond-Blackfan anemia ^[1].

HY-152670

JC2-11 1 Publications Verification	NOD-like Receptor (NLR) AIM2	Inflammation/Immunology
JC2-11 is an inhibitor of inflammatory corpuscles. JC2-11 inhibits domain-containing protein NLRC 4, absent in melanoma 2 (AIM 2) and non-canonical (NC) inflammatory corpuscles. JC2-11 reduces the secretion of caspase-1 (p20), the cleavage of gasdermin D (GSDMD), and the releases of *IL-1β* and lactate dehydrogenases (LDH) in inflammatory bodies. JC2-11 inhibits the activation of inflammatory bodies by destroying the production of reactive oxygen species and the activity of caspase-1 ^[1].

HY-P10240

Ac-WVAD-AMC	Fluorescent Dye	Others
Ac-WVAD-AMC is a fluorogenic substrate for *caspase 1* ^[1].

HY-P10243

Ac-VAD-CMK	Caspase	Neurological Disease
Ac-VAD-CMK is a pan inhibitor for *caspase 1* ^[1].

HY-121988

INF4E	NOD-like Receptor (NLR)	Inflammation/Immunology
INF4E is a potent NLRP3 inflammasome inhibitor. INF4E inhibits caspase-1 and NLRP3 ATPase activities. INF4E shows protection against the IR-induced myocardial injury and dysfunction ^[1] .

HY-13205

Belnacasan 120+ Cited Publications VX-765	Caspase	Inflammation/Immunology
Belnacasan (VX-765) is an orally bioactive proagent of VRT-043198, which is a potent and selective inhibitor of IL-converting enzyme (ICE)/caspase-1 with K_is of 0.8 nM and less than 0.6 nM for caspase-1 and caspase-4, respectively. Belnacasan (VX-765) inhibits the release of LPS-induced IL-1β and IL-18 by human PBMCs with an IC₅₀ of ~0.7 μM ^[1] .

HY-P10244

Ac-YVAD-FMK	Caspase	Others
Ac-YVAD-FMK is an inhibitor for caspase 1-like protease ^[1].

HY-12412

ML132 NCGC-00183434	Caspase	Inflammation/Immunology Cancer
ML132 (NCGC-00183434) is a selective *caspase 1* inhibitor with an IC₅₀ of 34.9 nM. ML132 shows good stability that can be utilized as molecular probes of *caspase 1*. ML132 can be used for research in the field of anti-cancer and anti-inflammatory ^[1].

HY-W041489

Chelidonic acid 1 Publications Verification	NF-κB Caspase	Inflammation/Immunology Cancer
Chelidonic acid is a component of Chelidonium majus L., used as an antimicrobial. Chelidonic acid also shows anti-inflammatory activity. Chelidonic acid has potential to inhibit IL-6 production by blocking NF-κB and *caspase-1* ^[1]. Chelidonic acid is a glutamate decarboxylase inhibitor, with a K_i of 1.2 μM .

HY-141622

SDZ 224-015	Interleukin Related Caspase SARS-CoV	Infection Inflammation/Immunology
SDZ 224-015 is an orally active inhibitor of the **interleukin-1 beta (IL-1β) converting enzyme and caspase-1**. SDZ 224-015 possesses anti-COVID-19 activity, targeting M ^pro (IC₅₀ of 30 nM) ^[1] .

HY-130480

Fructose-arginine	AIM2	Inflammation/Immunology
Fructose-arginine, an amino-sugar, is an AIM2 inflammasome activation inhibitor. Fructose-arginine attenuates the secretion of IL-1β, IL-18, and caspase-1, and Asc pyroptosome formation and Gsdmd cleavage resulting from AIM2 inflammasome activation ^[1].

HY-101019

Ossirene 2 Publications Verification AS101	Interleukin Related Caspase	Inflammation/Immunology Cancer
Ossirene (AS101), an immunomodulatory tellurium compound, is a potent *IL-1β* inhibitor ^[1]. Ossirene abolishes phosphorylation of STAT3 by inhibiting IL-10. Ossirene potently inhibits *Caspase-1* and is used for the autoimmune diseases and certain malignancies .

HY-156413

NLRP3 agonist 1	NOD-like Receptor (NLR)	Inflammation/Immunology
NLRP3 agonist 1 (compound 23) is a potent and orally active NLRP3 agonist. NLRP3 agonist 1 can activate the enzyme Caspase-1 to cleave pro-IL-1β and pro-IL-18 proinflammatory cytokines into their mature forms ^[1].

HY-168503

NLRP3-IN-54	NOD-like Receptor (NLR) Interleukin Related	Inflammation/Immunology
NLRP3-IN-54 (Compound C4) is an NLRP3 inhibitor. NLRP3-IN-54 can significantly reduce the levels of active *Caspase-1* and active *IL-1β* (IC₅₀ = 0.805 μM), can be used for inflammation research ^[1].

HY-P10276

Ac-VAD-AFC	Caspase	Cancer
Ac-VAD-AFC is a fluorescent substrate for caspases and can be used to test the activity of caspases .

HY-107541

O-1602 2 Publications Verification	GPR55	Neurological Disease
O-1602 is an agonist of GPR55 (G protein-coupled receptor 55). O-1602 reduces the number and activation of hippocampal microglia induced by METH (methamphetamine). O-1602 decreases the expression levels of NLRP3 inflammasome proteins, including NLRP3, ASC and Caspase-1 ^[1].

HY-P1093

Ac-LEHD-AFC 1 Publications Verification	Caspase	Others
Ac-LEHD-AFC is a fluorescent substrate for caspase-9, can be used to assess the activity of caspase .

HY-130476

Satratoxin G	Caspase Apoptosis	Cancer
Satratoxin G is a large cyclic mucor toxin. Satratoxin G induces apoptosis by activation of *caspase* .

HY-112226

VRT-043198 2 Publications Verification	Caspase Drug Metabolite	Inflammation/Immunology
VRT-043198, the agent metabolite of VX-765 (Belnacasan), is a potent, selective and blood-brain barrier permeable inhibitor of interleukin-converting enzyme/caspase-1 subfamily caspases. VRT-043198 exhibits K_i values of 0.8 nM and 0.6 nM for ICE/caspase-1 and caspase-4, respectively ^[1].

HY-120019A

Ac-YVAD-CHO acetate L-709049 acetate	Interleukin Related Caspase Apoptosis	Inflammation/Immunology
Ac-YVAD-CHO (L-709049) acetate is a potent, reversible, specific tetrapeptide interleukin-lβ converting enzyme (ICE) inhibitor with mouse and human K_i values of 3.0 and 0.76 nM. Ac-YVAD-CHO acetate is also a *caspase-1* inhibitor. Ac-YVAD-CHO acetate can suppress the production of mature IL-lβ ^[1] .

HY-120019

Ac-YVAD-CHO L-709049	Interleukin Related Apoptosis Caspase	Inflammation/Immunology
Ac-YVAD-CHO (L-709049) is a potent, reversible, specific tetrapeptide interleukin-lβ converting enzyme (ICE) inhibitor with mouse and human K_i values of 3.0 and 0.76 nM. Ac-YVAD-CHO is also a *caspase-1* inhibitor. Ac-YVAD-CHO can suppress the production of mature IL-lβ ^[1] .

HY-N12235

Sarglaroids F	Caspase	Inflammation/Immunology
Sarglaroids F (compound 6) is an anti-inflammatory agent isolated from the roots of Grass Coral. Sarglaroids F inhibits LPS/ATP-induced IL-1β release by affecting K+ efflux and reducing Caspase-1(P20) levels. Sarglaroids F is not cytotoxic to RAW264.7 cells ^[1].

HY-W041489R

Chelidonic acid (Standard)	NF-κB Caspase	Inflammation/Immunology Cancer
Chelidonic acid (Standard) is the analytical standard of Chelidonic acid. This product is intended for research and analytical applications. Chelidonic acid is a component of Chelidonium majus L., used as an antimicrobial. Chelidonic acid also shows anti-inflammatory activity. Chelidonic acid has potential to inhibit IL-6 production by blocking NF-κB and caspase-1 ^[1]. Chelidonic acid is a glutamate decarboxylase inhibitor, with a Ki of 1.2 μM .

HY-P10236

Ac-WEHD-pNA	Caspase	Others
Ac-WEHD-pNA is a colorimetric substrate for *caspase* 1, 4, 5 and 14, which is utilized to measure the caspase activity ^[1].

HY-146765

AMS-17	NOD-like Receptor (NLR)	Neurological Disease Inflammation/Immunology
AMS-17 is a potent NLRP3 inhibitor, inhibiting microglia activation in vitro and in vivo. AMS-17 also inhibits cytokines such as caspase-1, TNF-α, IL-1β and inducible nitric oxide synthase (iNOS) in N9 cells. AMS-17 can be used for researching inflammation-associated neurological disorders ^[1].

HY-P1009

Z-YVAD-FMK 15+ Cited Publications	Caspase	Cancer
Z-YVAD-FMK is a cell-permeable caspase-1 and -4 inhibitor with anti-inflammatory and anti-tumor activities ^[1].

HY-N0816

Polyphyllin VI 4 Publications Verification	Apoptosis Pyroptosis	Cancer
Polyphyllin VI, an active saponin, possess anti-cancer activities. Polyphyllin VI induces G2/M cell cycle arrest and triggers apoptosis. Polyphyllin VI induces *caspase-1*-mediated pyroptosis via the induction of ROS/NF-κB/NLRP3/GSDMD signal axis in non-small cell lung cancer ^[1] .

HY-N6037

Gardenin B 1 Publications Verification	Apoptosis	Cancer
Gardenin B is a flavonoid isolated from Gardenia jasminoides. Gardenin B induces cell death in human leukemia cells involves multiple caspases .

HY-P0109

(S,S)-Z-FA-FMK	Cathepsin	Others
(S,S)-Z-FA-FMK is a cell-permeable, irreversible cathepsin B inhibitor. (S,S)-Z-FA-FMK blocks LPS-induced production of IL-1α and IL-1β. (S,S)-Z-FA-FMK can be used as a negative control for caspase-1 and caspase-2 inhibitors because it lacks an aspartic acid residue at the P1 position ^[1] .

HY-107541R

O-1602 (Standard)	GPR55	Neurological Disease
O-1602 (Standard) is the analytical standard of O-1602. This product is intended for research and analytical applications. O-1602 is an agonist of GPR55 (G protein-coupled receptor 55). O-1602 reduces the number and activation of hippocampal microglia induced by METH (methamphetamine). O-1602 decreases the expression levels of NLRP3 inflammasome proteins, including NLRP3, ASC and Caspase-1 ^[1].

Cat. No.	Product Name

HY-L059

Pyroptosis Compound Library

1,574 compounds

Programmed cell death pathways, including apoptosis, pyroptosis and necroptosis, are regulated by unique sets of host proteins that coordinate a variety of biological outcomes. Pyroptosis is a highly inflammatory form of programmed cell death that occurs most frequently upon infection with intracellular pathogens and is likely to form part of the antimicrobial response. This process promotes the rapid clearance of various bacterial, viral, fungal and protozoan infections by removing intracellular replication niches and enhancing the host's defensive responses. Pyroptosis has been widely studied in inflammatory and infection disease models. Recently, there are growing evidences that pyroptosis also plays an important role in the development of cancer, cardiovascular diseases and Metabolic disorder, etc.

MCE designs a unique collection of 1,574 pyroptosis-related compounds mainly focusing on the key targets in the pyroptosis signaling pathway and can be used in the research of pyroptosis signal pathway and related diseases.

HY-L175

Inflammasomes related Compound Library

92 compounds

Inflammasomes are classic pattern recognition receptors for natural immune responses. Inflammasomes are polymeric protein complexes that regulate inflammatory responses and pyrolytic cell death, thereby exerting the host's defense against microorganisms. Inflammasomes sensors are associated with adapter proteins, activating inflammatory caspase-1, releasing inflammatory cytokines and inducing cell death, endowing the host with defense against pathogens. NLRP1, NLRP3, NLRC4, AIM2, and pyrin are considered typical inflammasomes because they convert cysteine asparaginase-1 into catalytically active capsaicin-1. In addition to infectious diseases, the importance of inflammasomes is also related to various clinical diseases, such as autoimmune diseases, neurodegeneration and metabolic disorders, and the development of cancer. Therefore, it is necessary to strictly regulate the activation and function of inflammasomes to avoid accidental host tissue damage while inducing pathogens to kill the inflammatory response.

MCE designs a unique collection of 92 inflammasomes related compounds. It is a good tool to be used for research on Inflammation, cancer and other diseases.

Cat. No.	Product Name	Type

HY-P2377

Ac-YVAD-AFC 4 Publications Verification	Dyes
Ac-YVAD-AFC is the the fluorometric peptide substrate of caspase-1, with λ excitation of 400 nm and λ emission of 505 nm ^[1] .

HY-P1093

Ac-LEHD-AFC 1 Publications Verification	Chromogenic Substrates
Ac-LEHD-AFC is a fluorescent substrate for caspase-9, can be used to assess the activity of caspase .

HY-P2616

Mca-YVADAP-Lys(Dnp)-OH	Chromogenic Substrates
Mca-YVADAP-Lys(Dnp)-OH is a fluorogenic substrate for *caspase-1* and angiotensin-converting enzyme 2 (ACE2) ^[1].

Cat. No.	Product Name	Target	Research Area

HY-P2091

Ac-YVAD-pNA	Caspase	Inflammation/Immunology
Ac-YVAD-pNA is a specific *Caspase-1* substrate. Ac-YVAD-pNA can be used to detect Caspase-1 activity. Caspase-1 is a key mediator of inflammatory processes ^[1] .

HY-P2617A

Ac-WEHD-AFC TFA	Caspase	Inflammation/Immunology Cancer
Ac-WEHD-AFC TFA is a *fluorogenic caspase-1* substrate*. Ac-WEHD-AFC TFA can measure caspase-1* fluorogenic activity and can be used for the research of tumor and inflammation ^[1].

HY-P4547

Ac-Trp-Glu-His-Asp-AMC AC-WEHD-AMC	Caspase	Others
Ac-Trp-Glu-His-Asp-AMC (AC-WEHD-AMC) is a potent fluorogenic substrate of caspase-1 ^[1].

HY-P10084

Ac-VAD-pNA	Caspase	Others
Ac-VAD-pNA is a *caspase-1* substrate. Ac-VAD-pNA can be used to detect caspase-1 activity ^[1].

HY-P4429

Z-YVAD-AFC	Peptides	Others
Z-YVAD-AFC is a fluorescent substrate for Caspase-1, which can be used to detect and measure the activity of Caspase-1 ^[1].

HY-P2617

Ac-WEHD-AFC	Caspase	Inflammation/Immunology Cancer
Ac-WEHD-AFC is a *fluorogenic caspase-1* substrate*. Ac-WEHD-AFC can measure caspase-1* fluorogenic activity and can be used for the research of tumor and inflammation ^[1].

HY-136728

Ac-YVAD-AOM	Caspase	Cancer
Ac-YVAD-AOM is the inhibitor of *caspase*-1 that shows antitumor activity ^[1].

HY-W792412

Z-YVAD-CMK	Caspase	Cancer
Z-YVAD-CMK is a *caspase-1* and *caspase-3* inhibitor ^[1].

HY-P5974

Z-YVAD-pNA Z-Tyr-Val-Ala-Asp-pNA	Caspase	Others
Z-YVAD-pNA (Z-Tyr-Val-Ala-Asp-pNA) is a *caspase-1* substrate ^[1].

HY-P5938

Ac-AAVALLPAVLLALLAP-YVAD-CHO	Caspase	Cancer
Ac-AAVALLPAVLLALLAP-YVAD-CHO is a cell-permeable *caspase*-1 inhibitor that has antitumor activity ^[1].

HY-P2377

Ac-YVAD-AFC 4 Publications Verification	Fluorescent Dye	Others
Ac-YVAD-AFC is the the fluorometric peptide substrate of caspase-1, with λ excitation of 400 nm and λ emission of 505 nm ^[1] .

HY-P2616

Mca-YVADAP-Lys(Dnp)-OH	Caspase Angiotensin-converting Enzyme (ACE)	Others
Mca-YVADAP-Lys(Dnp)-OH is a fluorogenic substrate for *caspase-1* and angiotensin-converting enzyme 2 (ACE2) ^[1].

HY-P4535

Ac-Trp-Glu-His-Asp-Aldehyde	Caspase	Inflammation/Immunology
Ac-Trp-Glu-His-Asp-Aldehyde is a potent and selective *caspase-1* inhibitor with a K_i value of 56 pM ^[1] .

HY-P2616A

Mca-YVADAP-Lys(Dnp)-OH TFA	Cholinesterase (ChE) Caspase	Others
Mca-YVADAP-Lys(Dnp)-OH TFA is a fluorogenic substrate for caspase-1 and angiotensin-converting enzyme 2 (ACE2) ^[1].

HY-P5122

Z-LEED-FMK	Caspase	Inflammation/Immunology
Z-LEED-FMK is a *caspase-13* and *caspase-4* inhibitor. Z-LEED-FMK also inhibits caspase-1 processing in S. typhimurium-infected macrophages ^[1] .

HY-P3761

Ac-Tyr-Val-Lys-Asp-aldehyde	Caspase	Others
Ac-Tyr-Val-Lys-Asp-aldehyde is a *caspase-1* inhibitor, can be used for disease research including anemia-associated to chronic diseases, chemotherapy-induced anemia and Diamond-Blackfan anemia ^[1].

HY-P10240

Ac-WVAD-AMC	Fluorescent Dye	Others
Ac-WVAD-AMC is a fluorogenic substrate for *caspase 1* ^[1].

HY-P10243

Ac-VAD-CMK	Caspase	Neurological Disease
Ac-VAD-CMK is a pan inhibitor for *caspase 1* ^[1].

HY-P10244

Ac-YVAD-FMK	Caspase	Others
Ac-YVAD-FMK is an inhibitor for caspase 1-like protease ^[1].

HY-P10276

Ac-VAD-AFC	Caspase	Cancer
Ac-VAD-AFC is a fluorescent substrate for caspases and can be used to test the activity of caspases .

HY-120019

Ac-YVAD-CHO L-709049	Interleukin Related Apoptosis Caspase	Inflammation/Immunology
Ac-YVAD-CHO (L-709049) is a potent, reversible, specific tetrapeptide interleukin-lβ converting enzyme (ICE) inhibitor with mouse and human K_i values of 3.0 and 0.76 nM. Ac-YVAD-CHO is also a *caspase-1* inhibitor. Ac-YVAD-CHO can suppress the production of mature IL-lβ ^[1] .

HY-P10236

Ac-WEHD-pNA	Caspase	Others
Ac-WEHD-pNA is a colorimetric substrate for *caspase* 1, 4, 5 and 14, which is utilized to measure the caspase activity ^[1].

HY-P1009

Z-YVAD-FMK Maximum Cited Publications 17 Publications Verification	Caspase	Cancer
Z-YVAD-FMK is a cell-permeable caspase-1 and -4 inhibitor with anti-inflammatory and anti-tumor activities ^[1].

HY-P0109

(S,S)-Z-FA-FMK	Cathepsin	Others
(S,S)-Z-FA-FMK is a cell-permeable, irreversible cathepsin B inhibitor. (S,S)-Z-FA-FMK blocks LPS-induced production of IL-1α and IL-1β. (S,S)-Z-FA-FMK can be used as a negative control for caspase-1 and caspase-2 inhibitors because it lacks an aspartic acid residue at the P1 position ^[1] .

HY-P10244F

Biotin-YVAD-FMK	Peptides	Infection
Biotin-YVAD-FMK is an inhibitor for vacuolar processing enzyme (VPE), with a 64% inhibition at 5 μM. Biotin-YVAD-FMK is an irreversible substrate for caspase 1 ^[1] .

HY-P5890

YVAD-CHO	Interleukin Related Caspase	Neurological Disease
YVAD-CHO is an interleukin-1β converting enzyme (ICE, caspase 1) inhibitor that can partially delay motoneurone death in lesioned facial nerve mice ^[1].

HY-P10142

Ac-YEVD-AMC	Fluorescent Dye	Others
Ac-YEVD-AMC is a fluorescent substrate of *caspase-1/11*. Ac-YEVD-AMC releases amino-4-methylcoumarin (AMC) for fluorescence detection when treating with cell lysate ^[1].

HY-W650842

Boc-Asp(OBzl)-CMK	Caspase	Cancer
Boc-Asp(OBzl)-CMK is an inhibitor for IL-1 converting enzyme (ICE, caspase1). Boc-Asp(OBzl)-CMK prevents death of CHP100 neuroblastoma cell, and IL-1β release elicited by the viral coat protein ^[1].

HY-12290

Arg-Gly-Asp-Ser 5 Publications Verification RGDS peptide; Fibronectin tetrapeptide	Integrin	Inflammation/Immunology
Arg-Gly-Asp-Ser is an integrin binding sequence that inhibits integrin receptor function. Arg-Gly-Asp-Ser directly and specifically bind pro-caspase-8, pro-caspase-9 and pro-caspase-3, while it does not bind pro-caspase-1.

HY-P2630

Suc-YVAD-pNA	Interleukin Related	Inflammation/Immunology
Suc-YVAD-pNA is a substrate of ICE. Interleukin-1β-converting enzyme (ICE) is a cysteine protease responsible for the cleavage of pre-interleukin-1β (pre-IL-1β) to the mature cytokine and a member of a family of related proteases (the caspases) .

HY-P0111

Z-WEHD-FMK 2 Publications Verification Z-WE(OMe)HD(OMe)-FMK	Caspase Cathepsin	Cancer
Z-WEHD-FMK is a potent, cell-permeable and irreversible *caspase-1/5* inhibitor. Z-WEHD-FMK also exhibits a robust inhibitory effect on cathepsin B activity (IC₅₀=6 μM). Z-WEHD-FMK can be used to investigate cells for evidence of apoptosis ^[1] .

HY-12290A

Arg-Gly-Asp-Ser TFA RGDS peptide TFA; Fibronectin tetrapeptide TFA	Integrin	Inflammation/Immunology
Arg-Gly-Asp-Ser (TFA) is an integrin binding sequence that inhibits integrin receptor function. Arg-Gly-Asp-Ser (TFA) directly and specifically bind pro-caspase-8, pro-caspase-9 and pro-caspase-3, while it does not bind pro-caspase-1 ^[1].

HY-P10674

QMT-CBT	Biochemical Assay Reagents	Neurological Disease
QMT-CBT is a near-infrared aggregation-induced luminescent photon. After activation of caspase1 (Cas1), QMT-CBT undergoes a CBT-Cys click reaction to form a cyclic dimer QMT-Dimer (the first aggregate) and assembles into nanoparticles (the second aggregate), turning the AIE signal "on" to enhance imaging of Alzheimer's disease (AD) ^[1].

Cat. No.	Product Name

HY-K2610

Caspase 1 Activity Assay Kit 1 Publications Verification
MCE Caspase 1 Activity Assay Kit provides a simple and convenient way for detecting the activity of detection of Caspase 1 activity that based on the spectrophotometric.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W041489

Chelidonic acid 1 Publications Verification	Classification of Application Fields Chelidonium majus Ketones, Aldehydes, Acids Source classification Plants Disease Research Fields Papaveraceae Cancer	NF-κB Caspase
Chelidonic acid is a component of Chelidonium majus L., used as an antimicrobial. Chelidonic acid also shows anti-inflammatory activity. Chelidonic acid has potential to inhibit IL-6 production by blocking NF-κB and *caspase-1* ^[1]. Chelidonic acid is a glutamate decarboxylase inhibitor, with a K_i of 1.2 μM .

HY-N0816

Polyphyllin VI 4 Publications Verification	Structural Classification other families Classification of Application Fields Source classification Plants Disease Research Fields Steroids Cancer	Apoptosis Pyroptosis
Polyphyllin VI, an active saponin, possess anti-cancer activities. Polyphyllin VI induces G2/M cell cycle arrest and triggers apoptosis. Polyphyllin VI induces *caspase-1*-mediated pyroptosis via the induction of ROS/NF-κB/NLRP3/GSDMD signal axis in non-small cell lung cancer ^[1] .

HY-N6037

Gardenin B 1 Publications Verification	Structural Classification Monophenols Flavonoids Classification of Application Fields Flavones Source classification Rubiaceae Phenols Plants Gardenia jasminoides Ellis Disease Research Fields Cancer	Apoptosis
Gardenin B is a flavonoid isolated from Gardenia jasminoides. Gardenin B induces cell death in human leukemia cells involves multiple caspases .

HY-N0619

Mulberroside A 3 Publications Verification	Structural Classification Stilbenes Classification of Application Fields Source classification Phenols Polyphenols Morus alba L. Plants Moraceae Inflammation/Immunology Disease Research Fields	TNF Receptor Interleukin Related Tyrosinase
Mulberroside A is one of the main bioactive constituent in mulberry (Morus alba L.) ^[1]. Mulberroside A decreases the expressions of TNF-α, *IL-1β, and IL-6* and inhibits the activation of NALP3, caspase-1, and NF-κB and the phosphorylation of ERK, JNK, and p38, exhibiting anti-inflammatory antiapoptotic effects . Mulberroside A shows inhibitory activity against mushroom tyrosinase with an IC₅₀ of 53.6 μM .

HY-101092

QS-21 4 Publications Verification Stimulon	Triterpenes Structural Classification other families Classification of Application Fields Terpenoids Source classification Plants Inflammation/Immunology Disease Research Fields	NOD-like Receptor (NLR)
QS-21, an immunostimulatory saponin, could be used as a potent vaccine adjuvant. QS-21 stimulates Th2 humoral and *Th1* cell-mediated immune responses through action on antigen presenting cells (APCs) and T cells. QS-21 can activate the NLRP3 inflammasome with subsequent release of caspase-1 dependent cytokines, IL-1β and IL-18 ^[1] .

HY-130476

Satratoxin G	Structural Classification Microorganisms Terpenoids Sesquiterpenes Source classification	Caspase Apoptosis
Satratoxin G is a large cyclic mucor toxin. Satratoxin G induces apoptosis by activation of *caspase* .

HY-N12235

Sarglaroids F	Structural Classification Ketones, Aldehydes, Acids Source classification Sarcandra glabra (Thunb.) Nakai Chloranthaceae Plants	Caspase
Sarglaroids F (compound 6) is an anti-inflammatory agent isolated from the roots of Grass Coral. Sarglaroids F inhibits LPS/ATP-induced IL-1β release by affecting K+ efflux and reducing Caspase-1(P20) levels. Sarglaroids F is not cytotoxic to RAW264.7 cells ^[1].

HY-W041489R

Chelidonic acid (Standard)	Structural Classification Chelidonium majus Ketones, Aldehydes, Acids Source classification Plants Papaveraceae	NF-κB Caspase
Chelidonic acid (Standard) is the analytical standard of Chelidonic acid. This product is intended for research and analytical applications. Chelidonic acid is a component of Chelidonium majus L., used as an antimicrobial. Chelidonic acid also shows anti-inflammatory activity. Chelidonic acid has potential to inhibit IL-6 production by blocking NF-κB and caspase-1 ^[1]. Chelidonic acid is a glutamate decarboxylase inhibitor, with a Ki of 1.2 μM .

HY-N0816R

Polyphyllin VI (Standard)	Structural Classification other families Source classification Plants Steroids	Apoptosis Pyroptosis
Polyphyllin VI (Standard) is the analytical standard of Polyphyllin VI. This product is intended for research and analytical applications. Polyphyllin VI, an active saponin, possess anti-cancer activities. Polyphyllin VI induces G2/M cell cycle arrest and triggers apoptosis. Polyphyllin VI induces caspase-1-mediated pyroptosis via the induction of ROS/NF-κB/NLRP3/GSDMD signal axis in non-small cell lung cancer ^[1] .

HY-N0619A

cis-Mulberroside A Mulberroside D	Stilbenes Classification of Application Fields Source classification Phenols Polyphenols Plants Moraceae Inflammation/Immunology Disease Research Fields Morus alba Linn.	TNF Receptor Interleukin Related Tyrosinase
cis-Mulberroside A (Mulberroside D) is the cis-isomer of Mulberroside A. Mulberroside A is one of the main bioactive constituent in mulberry (Morus alba L.) ^[1]. Mulberroside A decreases the expressions of TNF-α, *IL-1β, and IL-6* and inhibits the activation of NALP3, caspase-1, and NF-κB and the phosphorylation of ERK, JNK, and p38, exhibiting anti-inflammatory and anti-apoptotic effects . Mulberroside A shows inhibitory activity against mushroom tyrosinase with an IC₅₀ of 53.6 μM .

HY-N0619R

Mulberroside A (Standard)	Structural Classification Stilbenes Source classification Phenols Polyphenols Morus alba L. Plants Moraceae	TNF Receptor Interleukin Related Tyrosinase
Mulberroside A (Standard) is the analytical standard of Mulberroside A. This product is intended for research and analytical applications. Mulberroside A is one of the main bioactive constituent in mulberry (Morus alba L.) ^[1]. Mulberroside A decreases the expressions of TNF-α, IL-1β, and IL-6 and inhibits the activation of NALP3, caspase-1, and NF-κB and the phosphorylation of ERK, JNK, and p38, exhibiting anti-inflammatory antiapoptotic effects . Mulberroside A shows inhibitory activity against mushroom tyrosinase with an IC₅₀ of 53.6 μM .

HY-W011978

N-Acetyl-L-tryptophan	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite Mitochondrial Metabolism Neurokinin Receptor Caspase Interleukin Related
N-Acetyl-L-tryptophan is an antagonist of the neurokinin-1 receptor (NK-1R), disrupting the binding of substance P (SP) to *NK-1R. This action provides neuroprotective effects, improving memory deficits and motor impairments. N-Acetyl-L-tryptophan is also an inhibitor of cytochrome c (Cytochrome c), and it exerts antioxidant and anti-inflammatory effects by inhibiting the expression of IL-1β* and the activation of *caspase-1*. N-Acetyl-L-tryptophan holds promise for research in neurodegenerative and inflammatory diseases ^[1] .

HY-N6037R

Gardenin B (Standard)	Structural Classification Monophenols Flavonoids Flavones Source classification Rubiaceae Phenols Plants Gardenia jasminoides Ellis	Apoptosis
Gardenin B (Standard) is the analytical standard of Gardenin B. This product is intended for research and analytical applications. Gardenin B is a flavonoid isolated from Gardenia jasminoides. Gardenin B induces cell death in human leukemia cells involves multiple caspases .

HY-N0530

Dryocrassin ABBA 2 Publications Verification Dryocrassin	Infection Structural Classification Classification of Application Fields Dryopteridaceae Source classification Phenols Polyphenols Dryopteris crassirhizoma Nakai Plants Disease Research Fields	Apoptosis Influenza Virus
Dryocrassin ABBA (Dryocrassin) is an orally active phloroglucinol derivative that can be extracted from Phyllopteris officinalis. Dryocrassin ABBA has antitumor and antiviral activity. Dryocrassin ABBA induced apoptosis of human hepatocellular carcinoma cells through mitochondrial pathway mediated by *Caspase* .

HY-100381

Nigericin sodium salt Maximum Cited Publications 142 Publications Verification	Infection Structural Classification Microorganisms Classification of Application Fields Antibiotics Source classification Disease Research Disease Research Fields Other Antibiotics Cancer	Potassium Channel NOD-like Receptor (NLR) Bacterial Antibiotic Pyroptosis Wnt β-catenin
Nigericin sodium salt is an antibiotic derived from Streptomyces hygroscopicus that act as a K ⁺/H ⁺ ionophore, promoting K ⁺/H ⁺ exchange across mitochondrial membranes. Nigericin sodium salt is a NLRP3 activator. Nigericin sodium salt shows promising anti-cancer activities through decreasing intracellular pH (pHi), and inactivation of Wnt/β-catenin signals. Nigericin sodium salt induces pyroptosis through *caspase 1*/GSDMD in TNBC ^[1] .

HY-B2176R

ATP (Standard)	Structural Classification Alkaloids Human Gut Microbiota Metabolites Microorganisms other families Animals Other Alkaloids Source classification Plants Endogenous metabolite	Endogenous Metabolite
ATP (Standard) is the analytical standard of ATP. This product is intended for research and analytical applications. ATP (Adenosine 5'-triphosphate) is a central component of energy storage and metabolism in vivo. ATP provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP is an important endogenous signaling molecule in immunity and inflammation ^[1] . In Vitro: ATP (5 mM; 1 hour) co-treatment with LPS (1 μg/mL) has a synergistic effect on the activation of the NLRP3 inflammasome in HGFs . ATP (2 mM; 0.5-24 hours) induces secretion of IL-1β, KC and MIP-2 from BMDMs in a caspase-1 activation-dependent manner . ATP promotes neutrophil chemotaxis in vitro . In Vivo: ATP (50 mg/kg; i.p.) protects mice against bacterial infection in vivo . ATP induces the secretion of IL-1β, KC and MIP-2 and neutrophils recruitment in vivo .

HY-130413

Protectin D1 Neuroprotectin D1; NPD1	Structural Classification Neurological Disease Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Disease Research Fields	Endogenous Metabolite PI3K Akt HIF/HIF Prolyl-Hydroxylase Reactive Oxygen Species Caspase Interleukin Related MicroRNA
Protectin D1, a neuroprotectin D1 produced by neuronal cells, is a member of a newly discovered family of bioactive products derived from docosahexaenoic acid. Protectin D1 also serves as a specialized pro-resolving mediator, exhibiting effective in vivo pro-resolving activity in various human disease models. Additionally, Protectin D1 is an inhibitor of NALP3 inflammasomes and regulates the PI3K/AKT and *HIF-1α* signaling pathways. Protectin D1 exerts anti-inflammatory effects by reducing ROS levels, inhibiting the expression of NALP3, ASC, and *Caspase-1, and consequently decreasing the release of pro-inflammatory cytokines IL-1β* and IL-18. Furthermore, Protectin D1 enhances miRNA-210 expression, activates the PI3K/AKT signaling pathway, and exerts cardioprotective effects. Protectin D1 holds promise for research in cardiovascular diseases and inflammatory disorders ^[1] .

HY-100381R

Nigericin (sodium salt) (Standard)	Structural Classification Microorganisms Antibiotics Source classification Disease Research Other Antibiotics	Potassium Channel NOD-like Receptor (NLR) Bacterial Antibiotic Pyroptosis Wnt β-catenin
Nigericin (sodium salt) (Standard) is the analytical standard of Nigericin (sodium salt). This product is intended for research and analytical applications. Nigericin sodium salt is an antibiotic derived from Streptomyces hygroscopicus that act as a K ⁺/H ⁺ ionophore, promoting K ⁺/H ⁺ exchange across mitochondrial membranes. Nigericin sodium salt is a NLRP3 activator. Nigericin sodium salt shows promising anti-cancer activities through decreasing intracellular pH (pHi), and inactivation of Wnt/β-catenin signals. Nigericin sodium salt induces pyroptosis through *caspase 1*/GSDMD in TNBC ^[1] .

Cat. No.	Product Name	Chemical Structure

HY-B1138S

Fenbufen-d9

Fenbufen-d₉ (CL-82204-d9) is the deuterium labeled Fenbufen. Fenbufen (CL-82204) is an orally active non-steroidal anti-inflammatory drug (NSAID), with antipyretic effects. Fenbufen has potent activity in a variety of animal model, including carageenin edema, UV erythema and adjuvant arthritis. Fenbufen has inhibitory activities against COX-1 and COX-2 with IC50s of 3.9 μM and 8.1 μM, respectively. Fenbufen is a caspases (caspase-1, 3, 4, 5, 9) inhibitor[1][2][3][4][5].

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