Search Result

Results for "

erk1/2

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (4) Adenosine Receptor (1) Adenylate Cyclase (1) Adrenergic Receptor (3) Akt (10) Apoptosis (43) Arrestin (1) Aryl Hydrocarbon Receptor (1) Atg8/LC3 (1) Autophagy (9) Bacterial (2) Bcr-Abl (1) Beta-secretase (2) Bombesin Receptor (1) Bradykinin Receptor (1) c-Kit (1) c-Met/HGFR (5) Cannabinoid Receptor (2) Caspase (6) CCR (2) CDK (1) Chloride Channel (2) Cholinesterase (ChE) (2) COX (4) CXCR (1) Dopamine Receptor (1) EBV (1) EGFR (5) Endogenous Metabolite (11) ERK (84) Estrogen Receptor/ERR (2) FAK (1) Farnesyl Transferase (1) Ferroptosis (1) FGFR (1) Formyl Peptide Receptor (FPR) (1) Fungal (1) GABA Receptor (3) GnRH Receptor (2) GPR35 (1) GPR55 (4) HDAC (1) HIF/HIF Prolyl-Hydroxylase (1) Histone Methyltransferase (1) HSP (2) HSV (1) IKK (1) Integrin (2) Interleukin Related (4) Isotope-Labeled Compounds (1) Itk (1) JAK (1) JNK (8) Keap1-Nrf2 (2) MEK (6) Melanocortin Receptor (7) mGluR (1) Microtubule/Tubulin (1) MMP (8) MNK (1) NF-κB (12) Opioid Receptor (2) P2Y Receptor (2) p38 MAPK (8) PDGFR (3) PERK (2) Phosphatase (2) Phospholipase (2) PI3K (3) PKC (3) Potassium Channel (3) PPAR (2) Prostaglandin Receptor (1) PROTACs (1) Protease Activated Receptor (PAR) (2) Raf (1) Ras (4) Reactive Oxygen Species (4) ROS Kinase (1) SHP2 (1) Src (2) STAT (4) Syk (3) TNF Receptor (4) Toll-like Receptor (TLR) (2) VEGFR (4) Wnt (1) β-catenin (1)
By Research Areas:	Cancer (103) Cardiovascular Disease (17) Endocrinology (3) Infection (5) Inflammation/Immunology (51) Metabolic Disease (14) Neurological Disease (28)

By Targets:

5-HT Receptor (4)

Adenosine Receptor (1)

Adenylate Cyclase (1)

Adrenergic Receptor (3)

Akt (10)

Apoptosis (43)

Arrestin (1)

Aryl Hydrocarbon Receptor (1)

Atg8/LC3 (1)

Autophagy (9)

Bacterial (2)

Bcr-Abl (1)

Beta-secretase (2)

Bombesin Receptor (1)

Bradykinin Receptor (1)

c-Kit (1)

c-Met/HGFR (5)

Cannabinoid Receptor (2)

Caspase (6)

CCR (2)

CDK (1)

Chloride Channel (2)

Cholinesterase (ChE) (2)

COX (4)

CXCR (1)

Dopamine Receptor (1)

EBV (1)

EGFR (5)

Endogenous Metabolite (11)

ERK (84)

Estrogen Receptor/ERR (2)

FAK (1)

Farnesyl Transferase (1)

Ferroptosis (1)

FGFR (1)

Formyl Peptide Receptor (FPR) (1)

Fungal (1)

GABA Receptor (3)

GnRH Receptor (2)

GPR35 (1)

GPR55 (4)

HDAC (1)

HIF/HIF Prolyl-Hydroxylase (1)

Histone Methyltransferase (1)

HSP (2)

HSV (1)

IKK (1)

Integrin (2)

Interleukin Related (4)

Isotope-Labeled Compounds (1)

Itk (1)

JAK (1)

JNK (8)

Keap1-Nrf2 (2)

MEK (6)

Melanocortin Receptor (7)

mGluR (1)

Microtubule/Tubulin (1)

MMP (8)

MNK (1)

NF-κB (12)

Opioid Receptor (2)

P2Y Receptor (2)

p38 MAPK (8)

PDGFR (3)

PERK (2)

Phosphatase (2)

Phospholipase (2)

PI3K (3)

PKC (3)

Potassium Channel (3)

PPAR (2)

Prostaglandin Receptor (1)

PROTACs (1)

Protease Activated Receptor (PAR) (2)

Raf (1)

Ras (4)

Reactive Oxygen Species (4)

ROS Kinase (1)

SHP2 (1)

Src (2)

STAT (4)

Syk (3)

TNF Receptor (4)

Toll-like Receptor (TLR) (2)

VEGFR (4)

Wnt (1)

β-catenin (1)

By Research Areas:

Cancer (103)

Cardiovascular Disease (17)

Endocrinology (3)

Infection (5)

Inflammation/Immunology (51)

Metabolic Disease (14)

Neurological Disease (28)

180

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-153738

ERK1/2 inhibitor 9	ERK	Cancer
ERK1/2 inhibitor 9 (Probe 1) is a covalent *ERK1/2* inhibitor. ERK1/2 inhibitor 9 shows sub-micromolar activity in cells (A375 GI50=0.47 μM). ERK1/2 inhibitor 9 causes the downregulation of phospho-ERK1/2. ERK1/2 inhibitor 9 tagged trans-cyclo-octene (TCO) and Tz-Thalidomide (tetrazine tagged Thalidomide) can form the corresponding ERK-CLIPTAC to elicit degradation of ERK1/2 ^[1].

HY-112287

ERK1/2 inhibitor 1 5 Publications Verification	ERK	Cancer
ERK1/2 inhibitor 1 is a potent, orally bioavailable *ERK1/2 inhibitor, showing 60% inhibition at 1 nM and an IC₅₀* of 3.0 nM against ERK1 and ERK2, respectively ^[1].

HY-142433

ERK1/2 inhibitor 7	ERK	Cancer
ERK1/2 inhibitor 7 is a potent *ERK* inhibitor with an IC₅₀ of 0.94 nM for ERK2 (WO2021110168A1, WX006) ^[1].

HY-168171

ERK1/2 inhibitor 11	ERK Caspase Apoptosis	Cancer
ERK1/2 inhibitor 11 (compound L6) is a dual inhibitor of ERK1/2, lending to DSB accumulation and ERK1/2 expression degradation. ERK1/2 inhibitor 11 lowers the levels of BCL-2, and induces DNA damage by inhibiting PARP and ERK1/2. ERK1/2 inhibitor 11 activates caspase 3 to inducing apoptosis.

HY-162460

ERK1/2 inhibitor 10	ERK	Cancer
ERK1/2 inhibitor 10 (Compound 36c) is a potent *ERK1* and *ERK2* inhibitor (IC₅₀: 0.11 and 0.08 nM respectively). ERK1/2 inhibitor 10 inhibits ERK1/2 and blocks the phosphorylation expression of their downstream substrates p90RSK and c-Myc. ERK1/2 inhibitor 10 induces cell apoptosis and incomplete autophagy-related cell death. ERK1/2 inhibitor 10 shows potent antitumor efficacy against triple-negative breast cancer and colorectal cancer models harboring BRAF and RAS mutations ^[1].

HY-145026

ERK1/2 inhibitor 4	ERK	Inflammation/Immunology Cancer
ERK1/2 inhibitor 5 is a potent inhibitor of *ERK1/2. Mitogen-activated protein kinase (MAPK) plays an extremely important role in the signal transduction pathway, and extracellular signal regulated kinase (ERK) is a member of the MAPK family. ERK1*/2 inhibitor 5 has the potential for the research or prevention of cancer, inflammation or other proliferative diseases (extracted from patent WO2020238776A1) ^[1].

HY-145027

ERK1/2 inhibitor 5	ERK	Cancer
ERK1/2 inhibitor 5 is a potent inhibitor of *ERK1/2. Mitogen-activated protein kinase (MAPK) plays an extremely important role in the signal transduction pathway, and extracellular signal regulated kinase (ERK) is a member of the MAPK family. ERK1*/2 inhibitor 5 has the potential for the research or prevention of cancer, inflammation or other proliferative diseases (extracted from patent WO2020238776A1) ^[1].

HY-145025

ERK1/2 inhibitor 3	ERK	Inflammation/Immunology Cancer
ERK1/2 inhibitor 3 is a potent inhibitor of *ERK1/2. Mitogen-activated protein kinase (MAPK) plays an extremely important role in the signal transduction pathway, and extracellular signal regulated kinase (ERK) is a member of the MAPK family. ERK1*/2 inhibitor 3 has the potential for the research or prevention of cancer, inflammation or other proliferative diseases (extracted from patent WO2021218912A1, compound 1) ^[1].

HY-145028

ERK1/2 inhibitor 6	ERK	Inflammation/Immunology Cancer
ERK1/2 inhibitor 6 is a potent inhibitor of *ERK1/2. Mitogen-activated protein kinase (MAPK) plays an extremely important role in the signal transduction pathway, and extracellular signal regulated kinase (ERK) is a member of the MAPK family. ERK1*/2 inhibitor 6 has the potential for the research or prevention of cancer, inflammation or other proliferative diseases (extracted from patent WO2021063335A1, compound 1) ^[1].

HY-142437

ERK1/2 inhibitor 8	ERK	Cancer
ERK1/2 inhibitor 8 is a potent *ERK* inhibitor with an IC₅₀ of 0.48 nM for ERK2 (WO2021110168A1, WX007) ^[1].

HY-P5977

STE-MEK1(13) Ste-MPKKKPTPIQLNP-NH₂; erk Activation Inhibitor Peptide	ERK	Cancer
STE-MEK1(13) (Ste-MPKKKPTPIQLNP-NH ) is a cell permeable *ERK1/2* inhibitor (IC₅₀: 13-30 μM). STE-MEK1(13) inhibits ERK1/2 phosphorylation ^[1] .

HY-156393

Laxiflorin B	ERK	Cancer
Laxiflorin B, a herbal compound, is a novel selective *ERK*1/2 inhibitor that has antitumor activity ^[1].

HY-112181

KO-947 4 Publications Verification	ERK	Cancer
KO-947 is a potent and selective inhibitor of *ERK1/2* kinases with potential utility in MAPK pathway dysregulated tumors.

HY-B0513

Methylthiouracil 1 Publications Verification MTU	NF-κB TNF Receptor Interleukin Related ERK	Inflammation/Immunology Cancer
Methylthiouracil is an antithyroid agent. Methylthiouracil suppresses the production TNF-α and IL-6, and the activation of NF-κB and *ERK1/2*.

HY-N2283

Deltonin 1 Publications Verification	ERK Akt Endogenous Metabolite	Cancer
Deltonin, a steroidal saponin, isolated from Dioscorea zingiberensis, has antitumor activity; Deltonin inhibits *ERK1/2* and AKT activation.

HY-N2312

Mogrol 1 Publications Verification	ERK STAT	Cancer
Mogrol is a biometabolite of mogrosides, and acts via inhibition of the *ERK1/2* and STAT3 pathways, or reducing CREB activation and activating AMPK signaling.

HY-N1507

Tracheloside	Estrogen Receptor/ERR	Cancer
Tracheloside is an antiestrogenic lignin. Tracheloside promotes keratinocyte proliferation through ERK1/2 stimulation. Tracheloside is a good candidate to promote wound healing ^[1].

HY-16642A

LY2828360	Cannabinoid Receptor	Neurological Disease
LY2828360 is a slowly acting but efficacious G protein-biased cannabinoid (CB₂) agonist, inhibiting cAMP accumulation and activating ERK1/2 signaling.

HY-15312

WP1066 20+ Cited Publications	STAT JAK Apoptosis	Cancer
WP1066 is an inhibitor of JAK2 and STAT3, and also shows effect on STAT5 and ERK1/2, without affecting JAK1 and JAK3.

HY-126288

ASTX029 4 Publications Verification	ERK Apoptosis	Cancer
ASTX029 (Example 1) is a potent dual *ERK1/2* inhibitor (IC₅₀: 2.7 nM). ASTX029 has anti-cancer activity ^[1] .

HY-156394

Laxiflorin B-4	ERK	Cancer
Laxiflorin B-4 is modificative compound of Laxiflorin B (HY-156393), exhibited higher affinity for ERK1/2 and stronger tumor suppression ^[1].

HY-122246

ML192	GPR55 PKC ERK Arrestin	Metabolic Disease
ML192 is a selective ligand antagonist of GPR55. ML192 inhibits the β-arrestin trafficking, *ERK1/2* phosphorylation and PKCβII translocation ^[1].

HY-W001174

2,5-Dihydroxyacetophenone	ERK NF-κB	Inflammation/Immunology
2,5-Dihydroxyacetophenone, isolated from Rehmannia glutinosa, inhibits the production of inflammatory mediators in activated macrophages by blocking the *ERK1/2* and NF-κB signaling pathways ^[1].

HY-124740

ML00253764	Melanocortin Receptor	Cancer
ML00253764 is a selective melanocortin receptor 4 (MC4R) antagonist, can induce apoptosis by inhibiting ERK1/2 and Akt phosphorylation, and has anticancer activity ^[1].

HY-100403

Ro 67-7476 5+ Cited Publications	mGluR	Cancer
Ro 67-7476 is a potent positive allosteric modulator of *mGluR₁* and potentiates glutamate-induced calcium release in HEK293 cells expressing rat mGluR1a with an EC₅₀ of 60.1 nM ^[1] . Ro 67-7476 is a potent P-ERK1/2 agonist?and activates ERK1/2 phosphorylation in the absence of exogenously added glutamate (EC₅₀=163.3 nM) .

HY-50706

Selumetinib 60+ Cited Publications AZD6244; ARRY-142886	MEK Apoptosis	Cancer
Selumetinib (AZD6244) is selective, non-ATP-competitive oral *MEK1/2* inhibitor, with an IC₅₀ of 14 nM for MEK1. Selumetinib (AZD6244) inhibits ERK1/2 phosphorylation.

HY-P3751

[Tyr8] Bradykinin	Bradykinin Receptor ERK	Cardiovascular Disease Endocrinology
[Tyr8] Bradykinin is a B₂ kinin receptor agonist. [Tyr8] Bradykinin also stimulates ERK1/2 phosphorylation. [Tyr8] Bradykinin can be used as an internal standard ^[1].

HY-151367

SHR2415	ERK	Cancer
SHR2415 is a highly potent, selective and orally active *ERK1/2* inhibitor. SHR2415 has inhibition activity for ERK1 and ERK2 with IC₅₀ values of 2.8 nM and 5.9 nM, respectively. SHR2415 exhibits high potency with an IC₅₀ value of 44.6 nM in Colo205 cells. SHR2415 can be used for the research of cancer ^[1].

HY-50706A

Selumetinib sulfate 60+ Cited Publications AZD6244 sulfate; ARRY-142886 sulfate	MEK Apoptosis	Cancer
Selumetinib (AZD6244) is selective, non-ATP-competitive oral MEK1/2* inhibitor,* with an IC₅₀ of 14 nM for MEK1. Selumetinib (AZD6244) inhibits ERK1/2 phosphorylation.

HY-111407

MK-8353 2 Publications Verification SCH900353	ERK	Cancer
MK-8353 (SCH900353) is a potent, selective and orally available *ERK1/2* inhibitor, with IC₅₀s of 23.0 nM and 8.8 nM, respectively; MK-8353 has antitumor activity.

HY-N2858

Alpinumisoflavone acetate	Apoptosis	Cancer
Alpinumisoflavone acetate is a anticancer agent. Alpinumisoflavone acetate shows antiproliferative activity. Alpinumisoflavone acetate decreases the expression of phosphorylation of ERK1/2. Alpinumisoflavone acetate induces mitochondrial dysfunction and mitochondria-mediated Apoptosis. Alpinumisoflavone acetate has the potential for the research of HCC ^[1].

HY-B0513R

Methylthiouracil (Standard)	NF-κB TNF Receptor Interleukin Related ERK	Inflammation/Immunology Cancer
Methylthiouracil (Standard) is the analytical standard of Methylthiouracil. This product is intended for research and analytical applications. Methylthiouracil is an antithyroid agent. Methylthiouracil suppresses the production TNF-α and IL-6, and the activation of NF-κB and ERK1/2.

HY-N3828

epi-Eriocalyxin A	Apoptosis ERK JNK	Cancer
epi-Eriocalyxin A (Epieriocalyxin A), a diterpenoid isolated from Isodon eriocalyx, induces colon cancer apoptosis. epi-Eriocalyxin A also inhibits *ERK1/2* and JNK activation, which suppresses Bcl-2 expression ^[1].

HY-N2312R

Mogrol (Standard)	ERK STAT	Cancer
Mogrol (Standard) is the analytical standard of Mogrol. This product is intended for research and analytical applications. Mogrol is a biometabolite of mogrosides, and acts via inhibition of the ERK1/2 and STAT3 pathways, or reducing CREB activation and activating AMPK signaling.

HY-125522

Methyl helicterate	ERK Apoptosis	Inflammation/Immunology
Methyl helicterate is a triterpenoid, that can be isolated from Helicteres angustifolia (Sterculiaceae). Methyl helicterate inhibits hepatic stellate cell activation and promotes cell apoptosis through downregulating the *ERK1/2* signaling pathway ^[1] .

HY-N1507R

Tracheloside (Standard)	Estrogen Receptor/ERR	Cancer
Tracheloside (Standard) is the analytical standard of Tracheloside. This product is intended for research and analytical applications. Tracheloside is an antiestrogenic lignin. Tracheloside promotes keratinocyte proliferation through ERK1/2 stimulation. Tracheloside is a good candidate to promote wound healing ^[1].

HY-N0431

Astragaloside IV 15+ Cited Publications	MMP ERK JNK	Cancer
Astragaloside IV, an active component isolated from Astragalus membranaceus, suppresses the activation of *ERK1/2* and JNK, and downregulates matrix metalloproteases (MMP)-2, (MMP)-9 in MDA-MB-231 breast cancer cells.

HY-10520

CGP 57380 4 Publications Verification	MNK Apoptosis	Cancer
CGP 57380 is a cell-permeable pyrazolo-pyrimidine compound that acts as a selective inhibitor of *Mnk1* with IC₅₀ of 2.2 μM, but has no inhibitory activity against p38, JNK1, ERK1/2, PKC, or Src-like kinases.

HY-136579

ASN007 2 Publications Verification erk-IN-3	ERK	Cancer
ASN007 (ERK-IN-3) is a potent and orally active inhibitor of *ERK. ASN007 inhibits ERK1/2* with low single-digit nM IC₅₀ values. ASN007 can be used for the research of cancers driven by RAS mutations ^[1].

HY-136579A

ASN007 benzenesulfonate 2 Publications Verification erk-IN-3 benzenesulfonate	ERK	Cancer
ASN007 (ERK-IN-3) benzenesulfonate is a potent and orally active inhibitor of *ERK. ASN007 benzenesulfonate inhibits ERK1/2* with low single-digit nM IC₅₀ values. ASN007 benzenesulfonate can be used for the research of cancers driven by RAS mutations ^[1].

HY-113916

Onalespib lactate AT13387 lactate	HSP	Cancer
Onalespib lactate is a potent and cross the blood-brain barrier heat-shock-protein-90 (Hsp90) inhibitor with an K_d value of 0.71 nM. Onalespib lactate inhibits the proliferation, survival and migration. Onalespib lactate decreases the expression of EGFR, p-EGFR, AKT, P-AKT, ERK1/2, P-ERK1/2, S6, P-S6 protein. Onalespib lactate shows antitumor activity. Onalespib lactate has the potential for the research of non-small cell lung cancer (NSCLC) ^[1] .

HY-N10175

Berkeleyacetal C	Fungal Endogenous Metabolite	Inflammation/Immunology
Berkeleyacetal C, a meroterpenoid compound, shows favorable activity of inhibiting nitrogen oxide (NO) production of macrophages stimulated by lipopolysaccharide (LPS). Berkeleyacetal C exerts anti-inflammatory effects via inhibiting NF-κB, ERK1/2 and IRF3 signaling pathways ^[1].

HY-P5985

mSIRK 1 Publications Verification	ERK	Others
mSIRK (G-Protein βγ Binding Peptide) is an cell-permeable activator of *ERK*1/2, with EC₅₀ of 2.5-5 μM. mSIRK disrupts the interaction between α and βγ subunits and promotes α subunit dissociation without stimulating nucleotide exchange ^[1].

HY-P3513

β-Neo-Endorphin	ERK MMP	Neurological Disease
β-Neo-Endorphin is an endogenous opioid peptide. β-Neo-Endorphin is a hypothalamic “big” Leu-enkephalin of porcine origin. β-Neo-Endorphin shows activation of the *Erk1/2, MMP-2* and MMP-9 ^[1] .

HY-P3513A

β-Neo-Endorphin acetate	ERK MMP	Neurological Disease
β-Neo-Endorphin acetate is an endogenous opioid peptide. β-Neo-Endorphin acetate is a hypothalamic "big" Leu-enkephalin of porcine origin. β-Neo-Endorphin acetate shows activation of the *Erk1/2, MMP-2* and MMP-9 ^[1] .

HY-153445

MEK-IN-6	ERK MEK	Cancer
MEK-IN-6 (Example 69) is a MEK inhibitor. MEK-IN-6 inhibits *ERK1/2* (Thr202/Tyr204) phosphorylation in A375 cells (IC₅₀: 2 nM). MEK-IN-6 can be used for research of cancer ^[1].

HY-129566

Withanolide B	ERK Wnt β-catenin	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Withanolide B is an active component of W. somnifera Dunal. Withanolide B promotes osteogenic differentiation of hBMSCs via *ERK1/2* and Wnt/β-catenin signaling pathways. Withanolide B exhibits neuroprotective, anti-arthritic, anti-aging and anti-cancer effects ^[1] .

HY-B1456A

Fenoprofen 1 Publications Verification LILLY-53858	Melanocortin Receptor	Inflammation/Immunology
Fenoprofen (LILLY-53858) is a nonsteroidal anti-inflammatory agent (NSAID). Fenoprofen can be used to to relieve symptoms of arthritis (osteoarthritis and rheumatoid arthritis), such as inflammation, swelling, stiffness, and joint pain. Fenoprofen is an allosteric enhancer for melanocortin receptors. Fenoprofen also increases ERK1/2 activation ^[1] .

HY-158098

FGFR1 inhibitor-11	FGFR	Metabolic Disease
FGFR1 inhibitor-11 (compound 5g) binds to *FGFR1, inactivation of its downstream ERK1*/2 and IκBα/NF-κB signaling inhibited RANKL-induced osteoclastogenesis. FGFR1 inhibitor-11 has oral bioactivity ^[1].

HY-137977

DMU-212 2 Publications Verification	ERK Apoptosis	Cancer
DMU-212 is a methylated derivative of Resveratrol (HY-16561), with antimitotic, anti-proliferative, antioxidant and apoptosis promoting activities. DMU-212 induces mitotic arrest via induction of apoptosis and activation of *ERK1/2* protein. DMU-212 has orally active ^[1] .

Cat. No.	Product Name

HY-L010

MAPK Compound Library

544 compounds

MAPK families play an important role in complex cellular programs like proliferation, differentiation, development, transformation, and apoptosis. In mammalian cells, four MAPK families have been clearly characterized: ERK1/2, C-Jun N-terminal kinse/stress-activated protein kinase (JNK/SAPK) , p38 kinase and ERK5. They respond to different signals. Each MAPK-related cascade consists of three enzymes that are activated in series: a MAPK kinase kinase (MAPKKK), a MAPK kinase (MAPKK) and a MAP kinase (MAPK). MAPK signaling pathways has been implicated in the development of many human diseases including Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS) and various types of cancers.

MCE designs a unique collection of 544 MAPK signaling pathway inhibitors that act as a useful tool for MAPK-related drug screening and disease research.

Cat. No.	Product Name	Type

HY-W745090

Isomaltulose monohydrate

Biochemical Assay Reagents

Isomaltulose monohydrate is a fMLP inhibitor and also inhibits Src kinase, ERK1/2, p38 and AKT phosphorylation signals in immune regulation. Isomaltulose monohydrate can interfere with the interaction between the βγ subunit of the fMLP receptor Gi protein and its downstream molecules, thereby inhibiting fMLP-induced respiratory burst. Isomaltulose monohydrate inhibits fMLP (0.1 μM)-induced superoxide anion production (IC₅₀: 1.98 μM) , cathepsin G release (IC< sub>50: 2.76 μM) and chemotaxis. Isomaltulose monohydrate can improve excessive activation of neutrophils and reduce inflammation or tissue damage. A series of derivatives of Isomaltulose monohydrate are found to have inhibitory effects on FSGS-related TRPC6 functional mutants ^[1].

Cat. No.	Product Name	Target	Research Area

HY-P3751

[Tyr8] Bradykinin	Bradykinin Receptor ERK	Cardiovascular Disease Endocrinology
[Tyr8] Bradykinin is a B₂ kinin receptor agonist. [Tyr8] Bradykinin also stimulates ERK1/2 phosphorylation. [Tyr8] Bradykinin can be used as an internal standard ^[1].

HY-P5985

mSIRK 1 Publications Verification	ERK	Others
mSIRK (G-Protein βγ Binding Peptide) is an cell-permeable activator of *ERK*1/2, with EC₅₀ of 2.5-5 μM. mSIRK disrupts the interaction between α and βγ subunits and promotes α subunit dissociation without stimulating nucleotide exchange ^[1].

HY-P3513

β-Neo-Endorphin	ERK MMP	Neurological Disease
β-Neo-Endorphin is an endogenous opioid peptide. β-Neo-Endorphin is a hypothalamic “big” Leu-enkephalin of porcine origin. β-Neo-Endorphin shows activation of the *Erk1/2, MMP-2* and MMP-9 ^[1] .

HY-P0178A

LXW7 TFA	Integrin	Inflammation/Immunology
LXW7 TFA, a cyclic peptide containing Arg-Gly-Asp (RGD), is an integrin αvβ3 inhibitor. LXW7 has a high binding affinity to αvβ3 integrin with an IC₅₀ of 0.68 μM. LXW7 TFA increases phosphorylation of VEGFR-2 and activation of ERK1/2. Anti-inflammatory effect ^[1] .

HY-P3418

CKLF1-C27	CCR ERK	Inflammation/Immunology
CKLF1-C27, a C-terminal peptide of CKLF1, binds to CCR4 receptor and activates *ERK1/2* pathway. CKLF1-C27 can abrogate the effect of CKLF1 on cells by competing for CCR4 receptor. CKLF1-C27 shows great effect on promoting proliferation on HUVECs. CKLF1-C27 has the potential for psoriasis research ^[1].

HY-P5977

STE-MEK1(13) Ste-MPKKKPTPIQLNP-NH₂; erk Activation Inhibitor Peptide	ERK	Cancer
STE-MEK1(13) (Ste-MPKKKPTPIQLNP-NH ) is a cell permeable *ERK1/2* inhibitor (IC₅₀: 13-30 μM). STE-MEK1(13) inhibits ERK1/2 phosphorylation ^[1] .

HY-P5986

mSIRK (L9A)	Peptides	Others
mSIRK (L9A) is a cell-permeable, N-myristoylated G-Protein Binding Peptide (mSIRK). mSIRK (L9A) contains a single point mutation (Leu9 to Ala). mSIRK (L9A) cannot enhance ERK1/2 phosphorylation. mSIRK (L9A) can be used as a control peptide ^[1].

HY-110366

WAY-181187 oxalate SAX-187 oxalate	5-HT Receptor	Neurological Disease
WAY-181187 (SAX-187) oxalate is a potent and selective full 5-HT6 receptor agonist with a K_i of 2.2 nM and an EC₅₀ of 6.6 nM. WAY-181187 oxalate mediates 5-HT6 receptor-dependent signal pathways, such as cAMP, Fyn and ERK1/2 kinase, as specific agonist ^[1] .

HY-P0178

LXW7	Integrin	Inflammation/Immunology
LXW7, a cyclic peptide containing Arg-Gly-Asp (RGD), is an integrin αvβ3 inhibitor. LXW7 has a high binding affinity to αvβ3 integrin with an IC₅₀ of 0.68 μM. LXW7 increases phosphorylation of VEGFR-2 and activation of ERK1/2. Anti-inflammatory effect ^[1] .

HY-P3418A

CKLF1-C27 TFA	CCR ERK	Inflammation/Immunology
CKLF1-C27, a C-terminal peptide of CKLF1, binds to CCR4 receptor and activates *ERK1/2* pathway. CKLF1-C27 can abrogate the effect of CKLF1 on cells by competing for CCR4 receptor. CKLF1-C27 shows great effect on promoting proliferation on HUVECs. CKLF1-C27 has the potential for psoriasis research ^[1].

HY-P3259

AY254	Protease Activated Receptor (PAR)	Inflammation/Immunology Cancer
AY254 is an analogue of AY77 (HY-138951). AY254 is ERK-biased PAR2 agonist with an EC₅₀ of 2 nM. AY254 relieves cytokine-induced caspase 3/8 activation. AY254 also promotes scratch-wound healing and induced IL-8 secretion via PAR2-ERK1/2 signaling ^[1]

HY-P4322

H-Ile-Lys-Val-Ala-Val-OH 1 Publications Verification	ERK Akt	Neurological Disease Cancer
H-Ile-Lys-Val-Ala-Val-OH is one of the most potent active sites of laminin-1. H-Ile-Lys-Val-Ala-Val-OH promotes cell adhesion, neurite outgrowth, and tumor growth. H-Ile-Lys-Val-Ala-Val-OH stimulates BMMSC population growth and proliferation by activating *MAPK/ERK1/2* and PI3K/Akt signalling pathways ^[1] .

HY-P4052

Pinealon	ROS Kinase	Neurological Disease
Pinealon is a 3-amino acid peptide and shows neuroprotective properties. Pinealon prevents reactive oxygen species (ROS) accumulation and suppresses the activation of ERK 1/2. Pinealon stimulates the functional activity of the main cellular elements of brain tissue, reduces the level of spontaneous cell death. Pinealon protects the rat offspring from prenatal hyperhomocysteinemia ^[1] .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N2283

Deltonin 1 Publications Verification	Structural Classification Classification of Application Fields Source classification Dioscorea Zingiberensis C.H.Wright Plants Endogenous metabolite Disease Research Fields Steroids Cancer Dioscoreaceae	ERK Akt Endogenous Metabolite
Deltonin, a steroidal saponin, isolated from Dioscorea zingiberensis, has antitumor activity; Deltonin inhibits *ERK1/2* and AKT activation.

HY-N2312

Mogrol 1 Publications Verification	Triterpenes Structural Classification Classification of Application Fields Terpenoids Cucurbitaceae Siraitia grosvenorii (Swingle) C. Jeffrey ex Lu et Z. Y. Zhang Plants Disease Research Fields Cancer	ERK STAT
Mogrol is a biometabolite of mogrosides, and acts via inhibition of the *ERK1/2* and STAT3 pathways, or reducing CREB activation and activating AMPK signaling.

HY-N1507

Tracheloside	Structural Classification other families Classification of Application Fields Source classification Lignans Phenylpropanoids Plants Disease Research Fields Cancer	Estrogen Receptor/ERR
Tracheloside is an antiestrogenic lignin. Tracheloside promotes keratinocyte proliferation through ERK1/2 stimulation. Tracheloside is a good candidate to promote wound healing ^[1].

HY-W001174

2,5-Dihydroxyacetophenone	Structural Classification Classification of Application Fields Source classification Phenols Polyphenols Scrophulariaceae Plants Rehmannia glutinosa (Gaert.) Libosch. ex Fisch. et Mey Inflammation/Immunology Disease Research Fields	ERK NF-κB
2,5-Dihydroxyacetophenone, isolated from Rehmannia glutinosa, inhibits the production of inflammatory mediators in activated macrophages by blocking the *ERK1/2* and NF-κB signaling pathways ^[1].

HY-156393

Laxiflorin B	Structural Classification Lychnophora antillana Terpenoids Labiatae Source classification Diterpenoids Plants	ERK
Laxiflorin B, a herbal compound, is a novel selective *ERK*1/2 inhibitor that has antitumor activity ^[1].

HY-N2858

Alpinumisoflavone acetate	Structural Classification Source classification Coumarins Phenylpropanoids Plants Millettia thonningii (Schumach. & Thonn.) Baker Fabaceae	Apoptosis
Alpinumisoflavone acetate is a anticancer agent. Alpinumisoflavone acetate shows antiproliferative activity. Alpinumisoflavone acetate decreases the expression of phosphorylation of ERK1/2. Alpinumisoflavone acetate induces mitochondrial dysfunction and mitochondria-mediated Apoptosis. Alpinumisoflavone acetate has the potential for the research of HCC ^[1].

HY-N3828

epi-Eriocalyxin A	Other Terpenoids Structural Classification Lychnophora antillana Classification of Application Fields Terpenoids Labiatae Source classification Plants Disease Research Fields Cancer	Apoptosis ERK JNK
epi-Eriocalyxin A (Epieriocalyxin A), a diterpenoid isolated from Isodon eriocalyx, induces colon cancer apoptosis. epi-Eriocalyxin A also inhibits *ERK1/2* and JNK activation, which suppresses Bcl-2 expression ^[1].

HY-N2312R

Mogrol (Standard)	Triterpenes Structural Classification Terpenoids Cucurbitaceae Siraitia grosvenorii (Swingle) C. Jeffrey ex Lu et Z. Y. Zhang Plants	ERK STAT
Mogrol (Standard) is the analytical standard of Mogrol. This product is intended for research and analytical applications. Mogrol is a biometabolite of mogrosides, and acts via inhibition of the ERK1/2 and STAT3 pathways, or reducing CREB activation and activating AMPK signaling.

HY-125522

Methyl helicterate	Malvaceae Structural Classification Helicteres angustifolia L. Terpenoids Source classification Plants Pentacyclic Triterpenoids	ERK Apoptosis
Methyl helicterate is a triterpenoid, that can be isolated from Helicteres angustifolia (Sterculiaceae). Methyl helicterate inhibits hepatic stellate cell activation and promotes cell apoptosis through downregulating the *ERK1/2* signaling pathway ^[1] .

HY-N1507R

Tracheloside (Standard)	Structural Classification other families Source classification Lignans Phenylpropanoids Plants	Estrogen Receptor/ERR
Tracheloside (Standard) is the analytical standard of Tracheloside. This product is intended for research and analytical applications. Tracheloside is an antiestrogenic lignin. Tracheloside promotes keratinocyte proliferation through ERK1/2 stimulation. Tracheloside is a good candidate to promote wound healing ^[1].

HY-N0431

Astragaloside IV 15+ Cited Publications	Triterpenes Structural Classification Classification of Application Fields Leguminosae Terpenoids Source classification Astragalus membranaceus var. mongholicus (Bunge)P.K.Hsiao Plants Disease Research Fields Cancer	MMP ERK JNK
Astragaloside IV, an active component isolated from Astragalus membranaceus, suppresses the activation of *ERK1/2* and JNK, and downregulates matrix metalloproteases (MMP)-2, (MMP)-9 in MDA-MB-231 breast cancer cells.

HY-N10175

Berkeleyacetal C	Other Terpenoids Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Terpenoids Source classification Endogenous metabolite Disease Research Fields Inflammation/Immunology	Fungal Endogenous Metabolite
Berkeleyacetal C, a meroterpenoid compound, shows favorable activity of inhibiting nitrogen oxide (NO) production of macrophages stimulated by lipopolysaccharide (LPS). Berkeleyacetal C exerts anti-inflammatory effects via inhibiting NF-κB, ERK1/2 and IRF3 signaling pathways ^[1].

HY-129566

Withanolide B	Structural Classification Neurological Disease Classification of Application Fields Source classification Metabolic Disease Withania somnifera Solanaceae Plants Inflammation/Immunology Disease Research Fields Steroids	ERK Wnt β-catenin
Withanolide B is an active component of W. somnifera Dunal. Withanolide B promotes osteogenic differentiation of hBMSCs via *ERK1/2* and Wnt/β-catenin signaling pathways. Withanolide B exhibits neuroprotective, anti-arthritic, anti-aging and anti-cancer effects ^[1] .

HY-N0431R

Astragaloside IV (Standard)	Triterpenes Structural Classification Leguminosae Terpenoids Source classification Astragalus membranaceus var. mongholicus (Bunge)P.K.Hsiao Plants	MMP ERK JNK
Astragaloside IV (Standard) is the analytical standard of Astragaloside IV. This product is intended for research and analytical applications. Astragaloside IV, an active component isolated from Astragalus membranaceus, suppresses the activation of ERK1/2 and JNK, and downregulates matrix metalloproteases (MMP)-2, (MMP)-9 in MDA-MB-231 breast cancer cells.

HY-142026

Vitisin A (+)-Vitisin A	Structural Classification Microorganisms Source classification Vitis vinifera cv. Zalema Phenols Polyphenols Plants Vitaceae	NF-κB ERK
Vitisin A has antioxidative, anticancer, antiapoptotic, neuroprotective and anti-inflammatory effects. Vitisin A inhibits LPS-induced NO and iNOS production via down-regulation of ERK1/2 and p38 and the NF-κB signal pathway. Vitisin A also inhibits adipocyte differentiation. Vitisin A is a resveratrol tetramer that can be isolated from Vitis vinifera roots ^[1] .

HY-N2329

Piperlongumine 5+ Cited Publications Piplartine	Piper longum Linn. Infection Cardiovascular Disease Alkaloids Structural Classification Classification of Application Fields Source classification Pyridine Alkaloids Piperaceae Plants Disease Research Fields	ERK Reactive Oxygen Species Autophagy Apoptosis Bacterial Ferroptosis
Piperlongumine is a alkaloid ^[1], possesses ant-inflammatory, antibacterial, antiangiogenic, antioxidant, antitumor, and antidiabetic activities . Piperlongumine induces ROS, and induces apoptosis in cancer cell lines ^[1]. Piperlongumine shows anti-cardiac fibrosis activity, suppresses myofibroblast transformation via suppression of the ERK1/2 signaling pathway. Piperlongumin could be used in the study of migrasome .

HY-126477

NNK 1 Publications Verification	Structural Classification Alkaloids Classification of Application Fields Source classification Pyridine Alkaloids Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite
NNK is a nicotine-nitrosated derivative. NNK simultaneously stimulates Bcl2 phosphorylation exclusively at Ser ⁷⁰ and c-Myc at Thr ⁵⁸ and Ser ⁶² through activation of both *ERK1/2* and PKCα ^[1]. NNK induces survival and proliferation of human lung cancer cells. NNK can be used for lung cancer mice model structure .

HY-N1987

Cucurbitacin IIb 1 Publications Verification	Triterpenes Structural Classification Classification of Application Fields Terpenoids Cucurbitaceae Plants Hemsleya amabilis Diels Inflammation/Immunology Disease Research Fields	Apoptosis
Cucurbitacin IIb is an active component isolated from Hemsleya amabilis, induces apoptosis with anti-inflammatory activity. Cucurbitacin IIb inhibits phosphorylation of STAT3, JNK and Erk1/2, enhances the phosphorylation of IκB and NF-κB (p65), blocks nuclear translocation of NF-κB (p65) and decreases mRNA levels of IκBα and TNF-α ^[1].

HY-N10047

7,8-Didehydrocimigenol	Triterpenes Structural Classification Terpenoids Source classification Ranunculaceae Plants Cimicifuga foetida Linn.	NF-κB PPAR
7,8-Didehydrocimigenol is an active triterpenoid that can be isolated from Cimicifugae rhizoma. 7,8-Didehydrocimigenol inhibits TNF-α-induced VCAM-1 expression, inhibits NF-kB activity and phosphorylation of ERK1/2 and Akt, increases PPAR-γ expression. 7,8-Didehydrocimigenol can be used for the research of cardiovascular disorders such as atherosclerosis ^[1].

HY-N0265

Asperosaponin VI 2 Publications Verification	Cardiovascular Disease Triterpenes Structural Classification Classification of Application Fields Terpenoids Dipsacaceae Source classification Dipsacus asper Plants Disease Research Fields	Caspase Apoptosis
Asperosaponin VI, A saponin component from Dipsacus asper, induces osteoblast differentiation through BMP‐2/p38 and ERK1/2 pathway ^[1]. Asperosaponin Ⅵ inhibits apoptosis in hypoxia-induced cardiomyocyte by increasing the Bcl-2/Bax ratio and decreasing active caspase-3 expression, as well as enhancing of p-Akt and p-CREB .

HY-N0774

Isofraxidin 1 Publications Verification	Structural Classification Monophenols Classification of Application Fields Source classification Coumarins Phenols Phenylpropanoids Acanthopanax senticosus (Rupr. et Maxim.) Harms Plants Inflammation/Immunology Disease Research Fields Araliaceae	ERK COX MMP Toll-like Receptor (TLR)
Isofraxidin, a coumarin component from Acanthopanax senticosus, inhibits MMP-7 expression and cell invasion of human hepatoma cells. Isofraxidin inhibits the phosphorylation of *ERK1/2* in hepatoma cells ^[1]. Isofraxidin attenuates the expression of iNOS and COX-2, Isofraxidinalso inhibits TLR4/myeloid differentiation protein-2 (MD-2) complex formation .

HY-N2484

Methylnissolin Astrapterocarpan	Cardiovascular Disease Monophenols Flavonoids Classification of Application Fields Leguminosae Source classification Phenols Astragalus membranaceus var. mongholicus (Bunge)P.K.Hsiao Plants Other Flavonoids Disease Research Fields	PDGFR ERK
Methylnissolin (Astrapterocarpan), isolated from Astragalus membranaceus, inhibits platelet-derived growth factor (PDGF)-BB-induced cell proliferation with an IC₅₀ of 10 μM. Methylnissolin inhibits PDGF-BB-induced phosphorylation of extracellular signal-regulated kinase 1/2 (ERIC1/2) mitogen-activated protein (MAP) kinase. Methylnissolin inhibits PDGF-BB-induced vascular smooth muscle cell proliferation by inhibition of the *ERK1/2* MAP kinase cascade ^[1].

HY-113509

Lipoxin A4 1 Publications Verification LXA4	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Interleukin Related Endogenous Metabolite
Lipoxin A4 (LXA4), an endogenous lipoxygenase-derived eicosanoid mediator, has potent dual pro-resolving and anti-inflammatory properties ^[1]. Lipoxin A4 inhibits proliferation and inflammatory cytokine/chemokine production of human epidermal keratinocytes (NHEKs) associated with the ERK1/2 and NF-kB pathways . Lipoxin A4 inhibits serum amyloid A (SAA)-mediated IL-8 release with an IC₅₀ value of 25.74 nM .

HY-N11439

Albanol B	Structural Classification Natural Products Source classification Phenols Polyphenols Morus alba L. Plants Moraceae	CDK Akt ERK Apoptosis Bacterial
Albanol B is an arylbenzofuran derivative which can be isolated from mulberries. Albanol B exhibits anti-Alzheimer's disease, anti-bacterial and antioxidant activities. Albanol B inhibits cancer cells proliferation, down-regulates *CDK1* expression. Albanol B also induces cell cycle arrest at G2/M and apoptosis. And Albanol B induces mitochondrial ROS production and increases the phosphorylation levels of AKT and *ERK1/2* ^[1].

HY-126477R

NNK (Standard)	Structural Classification Alkaloids Source classification Pyridine Alkaloids Endogenous metabolite	Endogenous Metabolite
NNK (Standard) is the analytical standard of NNK. This product is intended for research and analytical applications. NNK is a nicotine-nitrosated derivative. NNK simultaneously stimulates Bcl2 phosphorylation exclusively at Ser70 and c-Myc at Thr58 and Ser62 through activation of both ERK1/2 and PKCα ^[1]. NNK induces survival and proliferation of human lung cancer cells. NNK can be used for lung cancer mice model structure .

HY-N7140

Gamma-Linolenic acid 3 Publications Verification γ-Linolenic acid	Structural Classification Classification of Application Fields Source classification Endocrine diseases Metabolic Disease Plants Endogenous metabolite Microorganisms Ketones, Aldehydes, Acids Labiatae Disease markers Espeletia schultzii Wedd. Disease Research Fields	Endogenous Metabolite Apoptosis NF-κB ERK JNK
Gamma-linolenic acid (γ-Linolenic acid) is an orally active unsaturated fatty acid. Gamma-linolenic acid exerts anti-inflammatory effects by inhibiting the NF-κB pathway and the phosphorylation of *ERK1/2* and JNK. At the same time, it exerts anticancer effects by inducing apoptosis (Apoptosis) in cancer cells. Additionally, Gamma-linolenic acid also has antioxidant and memory-improving effects. It holds promise for research in the fields of inflammation, neurology, and cancer diseases ^[1] .

HY-N0265R

Asperosaponin VI (Standard)	Triterpenes Structural Classification Terpenoids Dipsacaceae Source classification Dipsacus asper Plants	Caspase Apoptosis
Asperosaponin VI (Standard) is the analytical standard of Asperosaponin VI. This product is intended for research and analytical applications. Asperosaponin VI, A saponin component from Dipsacus asper, induces osteoblast differentiation through BMP‐2/p38 and ERK1/2 pathway ^[1]. Asperosaponin Ⅵ inhibits apoptosis in hypoxia-induced cardiomyocyte by increasing the Bcl-2/Bax ratio and decreasing active caspase-3 expression, as well as enhancing of p-Akt and p-CREB .

HY-N0774R

Isofraxidin (Standard)	Structural Classification Monophenols Source classification Coumarins Phenols Phenylpropanoids Acanthopanax senticosus (Rupr. et Maxim.) Harms Plants Araliaceae	ERK COX MMP Toll-like Receptor (TLR)
Isofraxidin (Standard) is the analytical standard of Isofraxidin. This product is intended for research and analytical applications. Isofraxidin, a coumarin component from Acanthopanax senticosus, inhibits MMP-7 expression and cell invasion of human hepatoma cells. Isofraxidin inhibits the phosphorylation of ERK1/2 in hepatoma cells ^[1]. Isofraxidin attenuates the expression of iNOS and COX-2, Isofraxidinalso inhibits TLR4/myeloid differentiation protein-2 (MD-2) complex formation .

HY-N6007

Chrysosplenol D	Infection Flavonols Flavonoids other families Classification of Application Fields Source classification Phenols Polyphenols Plants Disease Research Fields Inflammation/Immunology	Apoptosis
Chrysosplenol D is a methoxy flavonoid that induces ERK1/2-mediated apoptosis in triple negative human breast cancer cells. Chrysosplenol D also exhibits anti-inflammatory and moderate antitrypanosomal activities ^[1] .

HY-N2450

Sulforaphene	Structural Classification Natural Products Classification of Application Fields Source classification Plants Brassicaceae Disease Research Fields Cancer Raphanus sativus Linn.	Apoptosis EGFR ERK NF-κB Microtubule/Tubulin
Sulforaphene, isolated from radish seeds, exhibits an ED₅₀ against velvetleaf seedlings approximately 2 x 10 ^-4 M. Sulforaphene promotes cancer cells apoptosis and inhibits migration via inhibiting EGFR, *p-ERK1/2, NF‐κB* and other signals ^[1] .

HY-N0745

Senkyunolide I	Natural Products Classification of Application Fields Source classification Dicerothamnus rhinocerotis Plants Umbelliferae Disease Research Fields Inflammation/Immunology	Caspase
Senkyunolide I, isolated from Ligusticum chuanxiong Hort, is an anti-migraine compound. Senkyunolide I protects rat brain against focal cerebral ischemia-reperfusion injury by up-regulating p-Erk1/2, Nrf2/HO-1 and inhibiting caspase 3 ^[1] .

HY-N3298

Meranzin	Cardiovascular Disease other families Classification of Application Fields Neurological Disease Source classification Coumarins Phenylpropanoids Plants Disease Research Fields	Adrenergic Receptor
Meranzin is an absorbed bioactive compound from the Traditional Chinese Medicine (TCM) Chaihu-Shugan-San (CSS). Meranzin, isolated from leaves of Murraya exotica L., regulates the shared alpha 2-adrenoceptor and involves the AMPA-ERK1/2–BDNF signaling pathway. Meranzin has the potential for the prevention of the comorbidity of atherosclerosis and depression ^[1] .

HY-W744699

Larixol (+)-Larixol	Larix decidua Miller Structural Classification Natural Products Pinaceae Source classification Plants	Src ERK Akt
Larixol is an fMLP inhibitor and also inhibits Src kinase, ERK1/2, p38 and AKT phosphorylation signals in immune regulation. Larixol can interfere with the interaction between the βγ subunit of the fMLP receptor Gi protein and its downstream molecules, thereby inhibiting fMLP-induced respiratory burst. Larixol inhibits fMLP (0.1 μM)-induced superoxide anion production (IC₅₀: 1.98 μM), cathepsin G release (IC₅₀: 2.76 μM), and chemotaxis. Larixol improves neutrophil hyperactivation and reduces inflammation or tissue damage. A series of Larixol derivatives were found to have inhibitory effects on FSGS-related TRPC6 functional mutants ^[1] .

HY-N0092R

Inosine (Standard)	Structural Classification Natural Products Human Gut Microbiota Metabolites Microorganisms Source classification Endogenous metabolite	Adenosine Receptor Endogenous Metabolite
Inosine (Standard) is the analytical standard of Inosine. This product is intended for research and analytical applications. Inosine is an endogenous purine nucleoside produced by catabolism of adenosine. Inosine has anti-inflammatory, antinociceptive, immunomodulatory and neuroprotective effects. Inosine is an agonist for adenosine A₁ (A₁R) and A_2A (A_2AR) receptors ^[1] . In Vitro:Inosine dose-dependently stimulates cAMP production mediated through the A_2AR . Inosine dose-dependently induces hA_2AR-mediated ERK1/2 phosphorylation . Inosine (100 μM; 24 hours) reduces oxidative stress in MES 23.5 cells cultured with astrocytes . In Vivo:Inosine (10-100 mg/kg; i.p.) exhibits antinociceptive effect in mice .

HY-N3298R

Meranzin (Standard)	Structural Classification other families Source classification Coumarins Phenylpropanoids Plants	Adrenergic Receptor
Meranzin (Standard) is the analytical standard of Meranzin. This product is intended for research and analytical applications. Meranzin is an absorbed bioactive compound from the Traditional Chinese Medicine (TCM) Chaihu-Shugan-San (CSS). Meranzin, isolated from leaves of Murraya exotica L., regulates the shared alpha 2-adrenoceptor and involves the AMPA-ERK1/2–BDNF signaling pathway. Meranzin has the potential for the prevention of the comorbidity of atherosclerosis and depression ^[1] .

HY-N2292

Kinsenoside 1 Publications Verification	Structural Classification Natural Products Classification of Application Fields Orchidaceae Plants Anoectochilus Inflammation/Immunology Disease Research Fields	Keap1-Nrf2 Apoptosis
Kinsenoside is the main active ingredient of the genus plant, and has various biological activities. Kinsenoside and Nrf2 depend on the protection of nuclear cells (NPCs), which significantly reduces their ability to survive. Kinsenoside Active NPC Medium AKT-ERK1/2-Nrf2 Signal passage, Prevent physical decline, aging, harmonious physical function impairment. Kinsenoside can improve the puncture guide model for intermediate vertebral wall discharge (IDD).

HY-N12561

Pestanoid A	Structural Classification Microorganisms Terpenoids Source classification Diterpenoids	ERK p38 MAPK JNK
Pestanoid A is a rearranged pimarane diterpenoid osteoclastogenesis inhibitor with an IC₅₀ of 4.2 μM. Pestanoid A can be isolated from the marine mesophotic zone chalinidae sponge-associated fungus, Pestalotiopsis sp. NBUF145. Pestanoid A inhibits the receptor activator of NF-kB ligand-induced MAPK and NF-κB signaling by suppressing the phosphorylation of ERK1/2-JNK1/2-p38 MAPKs and NF-κB nuclear translocation. Pestanoid A can be used for the study of osteoporosis ^[1].

HY-N6796

Manumycin A	Infection Structural Classification Microorganisms Classification of Application Fields Antibiotics Source classification Disease Research Anticancer Disease Research Fields Other Antibiotics	Farnesyl Transferase Ras Apoptosis Phospholipase TNF Receptor Atg8/LC3
Manumycin A is a polyketide antibiotic and an inhibitor of thioredoxin reductase 1 (TrxR-1). Manumycin A can inhibit the growth of breast cancer cells and exert its anti-tumor activity through LC3. Manumycin A can downregulate the release of pro-inflammatory cytokines in human monocytes stimulated by TNF α, and has potential anti-inflammatory activity. Manumycin A can inhibit the *Ras/Raf/ERK1/2* signaling and hnRNP H1 in castration resistant prostate cancer cells to suppress exosome biogenesis and secretion ^[1] .

HY-N9541

Chaetoglobosin Vb	Structural Classification Alkaloids Microorganisms Pyrrole Alkaloids Source classification	Others
Chaetoglobosin Vb is a novel cytotoxic alkaloid with anti-inflammatory and antioxidant activities. Chaetoglobosin Vb can inhibit oxidative stress induced by LPS stimulation, reduce the production of reactive oxygen species and increase the expression of the antioxidant enzyme superoxide dismutase (SOD). Chaetoglobosin Vb significantly reduced the gene and protein expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) induced by LPS, and alleviated the production of proinflammatory cytokines such as TNF-α, IL-6 and IL-1β. Chaetoglobosin Vb exerts its biological activity through the TLR4-mediated MyD88-dependent signaling pathway and the TRIF-dependent signaling pathway, which is specifically manifested by inhibiting the phosphorylation of p38, ERK, and JNK MAPK and the translocation of NF-κB p65 subunit to the nucleus. Chaetoglobosin Vb showed no cytotoxic effect in the concentration range of 25-100 μM and promoted SOD enzyme activity and phosphorylation of p38, ERK1/2 and JNK in a dose-dependent manner ^[1].

HY-N0226

Epiberberine	Alkaloids Source classification Ranunculaceae Coptis chinensis Franch. Plants Isoquinoline Alkaloids	Cholinesterase (ChE) Beta-secretase
Epiberberine is an alkaloid isolated from Coptis chinensis, acts as a potent AChE and BChE inhibitor, and a non-competitive *BACE1* inhibitor, with IC₅₀s of 1.07, 6.03 and 8.55 μM, respectively. Epiberberine has antioxidant activity, with peroxynitrite ONOO ^- scavenging effect (IC₅₀, 16.83 μM), and can be used for the research of Alzheimer disease ^[1]. Epiberberine inhibits the early stage of differentiation of 3T3-L1 preadipocytes, downregulates the Raf/MEK1/2/ERK1/2 and AMPKα/Akt pathways . Epiberberinecan be used for the research of diabetic disease .

HY-N0226A

Epiberberine chloride 4 Publications Verification	Alkaloids Structural Classification Neurological Disease Classification of Application Fields Coptis chinensis Franch. Ranunculaceae Source classification Metabolic Disease Plants Isoquinoline Alkaloids Disease Research Fields	Cholinesterase (ChE) Beta-secretase Reactive Oxygen Species
Epiberberine chloride is an alkaloid isolated from Coptis chinensis, acts as a potent AChE and BChE inhibitor, and a non-competitive *BACE1* inhibitor, with IC₅₀s of 1.07, 6.03 and 8.55 μM, respectively. Epiberberine chloride has antioxidant activity, with peroxynitrite ONOO ^- scavenging effect (IC₅₀, 16.83 μM), and may protect against Alzheimer disease ^[1]. Epiberberine chloride inhibits the early stage of differentiation of 3T3-L1 preadipocytes, downregulates the Raf/MEK1/2/ERK1/2 and AMPKα/Akt pathways . Epiberberine has the potential effect in the research of diabetic disease .

HY-N2270

Chicanine 1 Publications Verification	Structural Classification Monophenols Classification of Application Fields Source classification Lignans Phenols Phenylpropanoids Plants Schisandraceae Schisandra chinensis (Turcz.) Baill. Inflammation/Immunology Disease Research Fields	p38 MAPK ERK IKK
Chicanine is a lignan compound of Schisandra chinesis, inhibits LPS-induced phosphorylation of p38 MAPK, *ERK 1/2* and IκB-α, with anti-inflammatory activity ^[1].

HY-19696B

Tauroursodeoxycholate dihydrate Maximum Cited Publications 64 Publications Verification Tauroursodeoxycholic acid dihydrate; TUDCA dihydrate; UR 906 dihydrate	Structural Classification Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Steroids Cancer	ERK Caspase Apoptosis Endogenous Metabolite
Tauroursodeoxycholate (Tauroursodeoxycholic acid; TDUCA) dihydrate is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and *caspase-12. Tauroursodeoxycholate also inhibits ERK* .

HY-N7110

6-Hydroxyflavone	Structural Classification Monophenols Flavonoids Classification of Application Fields Flavones Labiatae Source classification Phenols Plants Medicago truncatula Gaertn. Inflammation/Immunology Disease Research Fields	Akt ERK JNK GABA Receptor
6-Hydroxyflavone is an orally effective flavonoid compound. 6-Hydroxyflavone can inhibit LPS (HY-D1056) -induced NO production and has anti-inflammatory effects. 6-Hydroxyflavone promotes osteoblast differentiation by activating AKT, *ERK 1/2* and JNK signaling pathways. 6-Hydroxyflavone has an inhibitory effect on bovine hemoglobin (BHb) glycosylation. 6-Hydroxyflavone has a kidney protective effect. In addition, 6-Hydroxyflavone enhances GABA-induced current through the Benzodiazepine sites of γ-aminobutyric acid (GABA_A) receptors. 6-Hydroxyflavone shows a clear preference for α2 - and α3 - subtypes, which play an anti-anxiety role ^[1] .

Cat. No.	Product Name	Chemical Structure

HY-14188S

Amiodarone-d4 hydrochloride

Amiodarone-d₄ (hydrochloride) is the deuterium labeled Amiodarone hydrochloride. Amiodarone hydrochloride, a benzofuran-based Class III antiarrhythmic agent, inhibits WT outwardIhERG tails with an IC50 of ∼45 nM[1]. Amiodarone hydrochloride induces cell proliferation and myofibroblast differentiation via ERK1/2 and p38 MAPK signaling in fibroblasts[2]. Amiodarone hydrochloride can be used in the research of both supraventricular and ventricular arrhythmias[1].

HY-B1456AS

Fenoprofen-13C6(sodium salt hydrate)

Fenoprofen- ¹³C₆ (sodium hydrate) is the ¹³C labeled Fenoprofen (HY-B1456A). Fenoprofen is a nonsteroidal anti-inflammatory agent (NSAID). Fenoprofen can be used to to relieve symptoms of arthritis (osteoarthritis and rheumatoid arthritis), such as inflammation, swelling, stiffness, and joint pain. Fenoprofen is an allosteric enhancer for melanocortin receptors. Fenoprofen also increases ERK1/2 activation[1][2][3].

HY-113509S

Lipoxin A4-d5

Lipoxin A4-d₅ is the deuterium labeled Lipoxin A4. Lipoxin A4 (LXA4), an endogenous lipoxygenase-derived eicosanoid mediator, has potent dual pro-resolving and anti-inflammatory properties[1]. Lipoxin A4 inhibits proliferation and inflammatory cytokine/chemokine production of human epidermal keratinocytes (NHEKs) associated with the ERK1/2 and NF-kB pathways[2]. Lipoxin A4 inhibits serum amyloid A (SAA)-mediated IL-8 release with an IC50 value of 25.74 nM[3].

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P80393

	ERK1/2 Antibody	WB, ICC/IF, IP, FC	Human, Mouse, Rat
	ERK1/2 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 43/41 kDa, targeting to ERK1/2. It can be used for WB,ICC/IF,IP,FC assays with tag free, in the background of Human, Mouse, Rat.

HY-P80813

	*Phospho-ERK1/2* (Thr202/Thr185) Antibody** MAPK1/MAPK3	WB, IP	Human, Hamster, Rat
	Phospho-ERK1/2 (Thr202/Thr185) Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 44,42 kDa, targeting to Phospho-ERK1/2 (Thr202/Thr185). It can be used for WB,IP assays with tag free, in the background of Human, Hamster, Rat.

HY-P80815

	*Phospho-ERK1/2* (Tyr204/Tyr187) Antibody** MAPK1/MAPK3	WB, IHC-P, ICC/IF	Human, Mouse, Rat
	Phospho-ERK1/2 (Tyr204/Tyr187) Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 42,44 kDa, targeting to Phospho-ERK1/2 (Tyr204/Tyr187). It can be used for WB,IHC-P,ICC/IF assays with tag free, in the background of Human, Mouse, Rat.

HY-P80392

	*Phospho-ERK1/2* (Thr202/Tyr204)/(Thr185/Tyr187) Antibody (YA455)**	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse, Rat
	Phospho-ERK1/2 (Thr202/Tyr204)/(Thr185/Tyr187) Antibody (YA455) is a non-conjugated and Rabbit origined monoclonal antibody about 41/43 kDa, targeting to Erk1 (pT202/pY204) + Erk2 (pT185/pY187). It can be used for WB,IP,IHC-P assays with tag free, in the background of Human.

HY-P80814

	*Phospho-ERK1/2* (Thr202/Tyr204)/(Thr185/Tyr187) Antibody** MAPK1/MAPK3	WB	Human, Mouse, Rat
	Phospho-ERK1/2 (Thr202/Tyr204)/(Thr185/Tyr187) Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 44,42 kDa, targeting to Phospho-ERK1/2 (Thr202/Tyr204)/(Thr185/Tyr187). It can be used for WB assays with tag free, in the background of Human, Mouse, Rat.

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