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Results for "

estrogen receptor α

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Estrogen Receptor/ERR (117) Androgen Receptor (1) Apoptosis (13) Autophagy (3) Bacterial (2) Cytochrome P450 (2) E3 Ligase Ligand-Linker Conjugates (7) Endogenous Metabolite (15) Glucocorticoid Receptor (2) HDAC (1) HIV (2) Isotope-Labeled Compounds (9) Ligands for E3 Ligase (1) Ligands for Target Protein for PROTAC (2) Liposome (3) LXR (2) Mitophagy (2) NF-κB (1) Parasite (2) Potassium Channel (1) PROTAC-Linker Conjugates for PAC (1) PROTACs (12) Reactive Oxygen Species (1) RET (1) SNIPERs (2) Target Protein Ligand-Linker Conjugates (1) Wnt (1)
By Research Areas:	Cancer (103) Cardiovascular Disease (4) Endocrinology (17) Infection (1) Inflammation/Immunology (5) Metabolic Disease (17) Neurological Disease (2)
Click Chemistry:	Azide (2)
Oligonucleotides:	Emulsifiers (1) Cholesterol (1)

136

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

Targets Recommended: Estrogen Receptor/ERR

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0723

Ospemifene 2 Publications Verification FC-1271a	Estrogen Receptor/ERR	Cancer
Ospemifene is a non-estrogen selective **estrogen receptor modulator (SERM), with K_i*s of 380 and 410 nM for estrogen* receptor α (ERα) and ERβ, respectively. Ospemifene can be used for the research of vaginal atrophy and breast cancer .

HY-100689

Propyl pyrazole triol 10+ Cited Publications PPT	Estrogen Receptor/ERR	Cancer
Propyl pyrazole triol (PPT) is a selective estrogen receptor alpha (ERα) agonist. The relative binding affinity of Propyl pyrazole triol for ERα (ERα: 49%) around 410 times higher compared with estrogen receptor beta (ERβ: 0.12%) .

HY-18719A

Endoxifen Z-isomer hydrochloride 3 Publications Verification	Estrogen Receptor/ERR Potassium Channel	Cancer
Endoxifen Z-isomer hydrochloride is the most important Tamoxifen metabolite responsible for eliciting the anti-estrogenic effects of this drug in breast cancer cells expressing estrogen receptor-alpha (ERα).

HY-143227

DK3	Estrogen Receptor/ERR	Metabolic Disease
DK3 is a potent and selective estrogen-related receptor alpha (ERRα) agonist .

HY-150692

Estrogen receptor α antagonist 1	Estrogen Receptor/ERR	Cancer
Estrogen receptor α antagonist 1 (compound 35) is a highly selective antagonist of estrogen receptor α, with IC₅₀s of 0.02, 6.55 and 7.73 μM for estrogen receptor α, estrogen receptor β and MCF-7 cells, respectively. Estrogen receptor α antagonist 1 can be used for the research of cancer .

HY-144137

Estrogen receptor antagonist 1	Estrogen Receptor/ERR	Cancer
Estrogen receptor antagonist 1 is a selective **estrogen receptor** antagonist. Estrogen (E2) and estrogen alpha receptor (ERα) are important drivers of breast cancer development. Estrogen receptor antagonist 1 has the potential for the research of breast cancer diseases (extracted from patent WO2021249533A1, compound 4) .

HY-144138

Estrogen receptor antagonist 2	Estrogen Receptor/ERR	Cancer
Estrogen receptor antagonist 2 is a selective **estrogen receptor** downregulator. Estrogen (E2) and estrogen alpha receptor (ERα) are important drivers of breast cancer development. Estrogen receptor antagonist 2 has the potential for the research of breast cancer diseases (extracted from patent WO2021228210A1, compound 3) .

HY-163467

CHEMBL4224880	Others	Cancer
CHEMBL4224880 is an estrogen receptor-α (ER-α) binder .

HY-128839

PROTAC ERRα Degrader-2	PROTACs Estrogen Receptor/ERR	Cancer
PROTAC ERRα Degrader-2 comprises a MDM2 ligand binding group, a linker and an **estrogen-related receptor alpha (ERRa*) binding group. PROTAC ERRα Degrader-2 is an estrogen-related receptor* alpha (ERRa) degrader .

HY-128838

PROTAC ERRα Degrader-1	PROTACs Estrogen Receptor/ERR	Cancer
PROTAC ERRα Degrader-1 comprises a MDM2 ligand binding group, a linker and an **estrogen-related receptor alpha (ERRa*) binding group. PROTAC ERRα Degrader-1 is an PROTAC estrogen-related receptor* alpha (ERRa) degrader .

HY-110392

CMP8	Estrogen Receptor/ERR	Cancer
CMP8, a selective ligand for **estrogen receptor*, binds to the mutant estrogen* receptor ligand binding domain (ERLBD). CMP8 exhibits IC₅₀ values of 29 nM , 41 nM, 1100 nM and 2200 nM for MGERα, MGRERα, hERα and hERβ, respectively .

HY-12870

AZD9496 20+ Cited Publications	Estrogen Receptor/ERR	Cancer
AZD9496 is an effective, selective estrogen receptor (ERα) antagonist with an IC₅₀ of 0.28 nM. AZD9496 is an orally active, selective estrogen receptor degrader (SERD).

HY-B1662

Hexestrol 2 Publications Verification	Estrogen Receptor/ERR	Endocrinology
Hexestrol is a nonsteroidal synthetic estrogen, with a K_i of 0.06 and 0.06 nM for estrogen receptor alpha (ERα) and ERβ. Hexestrol can be used for the research of the diseases caused by estrogen deficiencym, and it also can increase the weight of cattle .

HY-150601

Estrogen receptor-IN-1	Estrogen Receptor/ERR	Metabolic Disease
Estrogen receptor-IN-1 (compound 16) is a potent estrogen receptor (ER) inhibitor with IC₅₀s of 13, 5µM for ERα and Erβ, respectively .

HY-138690

Estrogen receptor modulator 6	Estrogen Receptor/ERR	Endocrinology
Estrogen receptor modulator 6 (compound 3a) is a selective estrogen receptor (ER) β agonist (K_i=0.44 nM). Estrogen receptor modulator 6 displays 19-fold selectivity for ERβ over ERα(K_i=8.4 nM) .

HY-N2448

Lindleyin	Estrogen Receptor/ERR	Endocrinology
Lindleyin, isolated from Rhei rhizoma, mediates hormonal effects through estrogen receptors. Lindleyin binds to ERα with estrogenic activity .

HY-128838A

(rel)-PROTAC ERRα Degrader-1 1 Publications Verification	Estrogen Receptor/ERR	Others
(rel)-PROTAC ERRα Degrader-1 is a relative configuration of PROTAC ERRα Degrader-1. PROTAC ERRα Degrader-1 comprises a MDM2 ligand binding group, a linker and an **estrogen-related receptor alpha (ERRa*) binding group. PROTAC ERRα Degrader-1 is an estrogen-related receptor* alpha (ERRa) degrader .

HY-153700

Estrogen receptor modulator 8	Estrogen Receptor/ERR	Endocrinology
Estrogen receptor modulator 8 (compound 4) is an orally active inhibitor of Estrogen Receptor/ERR α (IC₅₀=0.437 nM, MCF-7 cells). Estrogen receptor modulator 8 inhibits MCF-7 cells proliferation with an IC₅₀ value of 0.1 nM .

HY-145341

GNE-149	Estrogen Receptor/ERR	Cancer
GNE-149 is an orally bioavailable full antagonist of estrogen receptor α (ERα; IC₅₀=0.053 nM). GNE-149 is a selective estrogen receptor degrader (SERD). GNE-149 can be used for the research of breast cancer .

HY-146424

OBHS	Estrogen Receptor/ERR	Neurological Disease Cancer
OBHS is an estrogen receptor α (ERα) inhibitor. OBHS can also be used as a blowing agent .

HY-111484A

GDC-0927 Racemate SRN-927 Racemate	Estrogen Receptor/ERR	Cancer
GDC-0927 Racemate (SRN-927 Racemate) is an estrogen receptor (ER) degrader that can effectively inhibit the activity of *ER-α* with an IC₅₀ value of 0.2 nM and can be used in diseases related to estrogen receptors.

HY-107045

CHF 4227 free base	Estrogen Receptor/ERR	Endocrinology
CHF 4227 free base is an orally active and selective **estrogen receptor** modulator (SERM) with high affinity to the human estrogen receptor-α and -β (K_i values of 0.017 nM and 0.099 nM, respectively) .

HY-150693

Estrogen receptor β antagonist 2	Estrogen Receptor/ERR	Cancer
Estrogen receptor β antagonist 2 is a potent and selective estrogen receptor β (ERβ) antagonist with IC₅₀s of 109.10, 0.63 µM for Erα and Erβ, respectively .

HY-B1662R

Hexestrol (Standard)	Estrogen Receptor/ERR	Endocrinology
Hexestrol (Standard) is the analytical standard of Hexestrol. This product is intended for research and analytical applications. Hexestrol is a nonsteroidal synthetic estrogen, with a Ki of 0.06 and 0.06 nM for estrogen receptor alpha (ERα) and ERβ. Hexestrol can be used for the research of the diseases caused by estrogen deficiencym, and it also can increase the weight of cattle .

HY-B0723S

Ospemifene D4 FC-1271a d₄	Estrogen Receptor/ERR	Cancer
Ospemifene-d₄ is a deuterium labeled Ospemifene. Ospemifene is a selective and orally active estrogen receptor modulator for the prevention of osteoporosis with IC50 values of 827 nM and 1633 nM for estrogen receptor α (ERα) and ERβ, respectively. Ospemifene has bone-sparing, antitumor, and cholesterol-lowering effects[1][2].

HY-119418

Desketoraloxifene	Estrogen Receptor/ERR	Cancer
Desketoraloxifene is an estrogen receptors alpha (ERα) activator at an AP-1 site. Desketoraloxifene can be used for the research of osteoporosis and breast cancer .

HY-150803

VHL Ligand 14	Ligands for E3 Ligase	Cancer
VHL Ligand 14 (Compound 11) is a VHL ligand for design of PROTAC estrogen receptor α (ERα) degraders, with a binding affinity IC₅₀ of 196 nM .

HY-U00425

PROTAC ERRα ligand 1	Estrogen Receptor/ERR	Cancer
PROTAC ERRα ligand 1 is an estrogen-related receptor α (ERRα) antagonist with IC₅₀s of 0.04 and 2.8 μM for ERRα and ERRγ, respectively .

HY-111845

Estrone-N-O-C1-amido ERα ligand 1	Estrogen Receptor/ERR Ligands for Target Protein for PROTAC	Cancer
Estrone-N-O-C1-amido (ERα ligand 1) is an Estrone-based estrogen ligand, which targets estrogen receptor α (ERα). Estrone-N-O-C1-amido (ERα ligand 1) binds to cIAP1 ligand Bestatin via a linker to form SNIPER .

HY-14650

DHEA 25+ Cited Publications Prasterone; Dehydroisoandrosterone; Dehydroepiandrosterone	Androgen Receptor Endogenous Metabolite	Cardiovascular Disease Endocrinology Cancer
DHEA (Prasterone) is one of the most abundant steroid hormones. DHEA (Prasterone) mediates its action via multiple signaling pathways involving specific membrane receptors and via transformation into androgen and estrogen derivatives (e.g., androgens, estrogens, 7α and 7β DHEA, and 7α and 7β epiandrosterone derivatives) acting through their specific receptors.

HY-168644

Erα-IN-1	Estrogen Receptor/ERR	Endocrinology
Erα-IN-1 (compound 3c) is an inhibitor of **estrogen receptor α (ERα**), blocking ERa activity in MCF7/ERE-LUC cells. .

HY-131404

TPBM	Estrogen Receptor/ERR	Cancer
TPBM is a potent estrogen receptor α (ERα) inhibitor with an IC₅₀ value of 9 μM for 17β-estradiol (E2)-ERα. TPBM reduces E2·ERα recruitment to an endogenous estrogen-responsive gene. TPBM inhibits E2-dependent growth of ERα-positive cancer cells (IC₅₀=5 μM). TPBM is not toxic to cells and does not affect estrogen-independent cell growth .

HY-103456

PHTPP 20+ Cited Publications	Estrogen Receptor/ERR	Cancer
PHTPP is a selective estrogen receptor β (ERβ) antagonist with 36-fold selectivity over ERα .

HY-12870A

AZD9496 maleate 20+ Cited Publications	Estrogen Receptor/ERR	Cancer
AZD9496 maleate is a potent and selective estrogen receptor (ERα) antagonist with IC₅₀ of 0.28 nM. AZD9496 maleate is an orally bioavailable selective oestrogen receptor degrader (SERD).

HY-125703

Ferutinin	Estrogen Receptor/ERR Apoptosis	Infection Inflammation/Immunology Endocrinology Cancer
Ferutinin, a natural terpenoid compound, is an estrogen receptor ERα agonist and estrogen ERβ-receptor agonist/antagonist with IC₅₀s of 33.1 nM and 180.5 nM, respectively. Ferutinin acts as an electrogenic Ca ²⁺-ionophore that increases calcium permeability of lipid bilayer membranes, mitochondria. Ferutinin possesses estrogenic, antitumor, antibacterial and antiinflammatory activities .

HY-163680

ERα degrader 9	Estrogen Receptor/ERR Cytochrome P450	Cancer
ERα degrader 9 is a dual targeting ligand for estrogen receptor α (ERα) and aromatase (ARO). ERα degrader 9 can be utilized for synthesis of PROTAC ERα Degrader-9 (HY-163679) .

HY-N6710

α-Zearalenol	Estrogen Receptor/ERR	Inflammation/Immunology
α-Zearalenol is a Mycotoxin with high affinity for the estrogen receptors (ER), α-Zearalenol is the derivative of zearalenone (ZEN), causes reproductive disorders in animals, due to its xenoestrogenic effects .

HY-168101

ERα degrader 11	Estrogen Receptor/ERR	Cancer
ERα degrader 11 (compound B16) is a selective ERα degrader that can be used as an estrogen receptor probe to investigate ER status in ER-positive breast cancer cells .

HY-146267

ERα degrader 5	Estrogen Receptor/ERR	Cancer
ERα degrader 5 (Compound 40) is a selective, orally bioavailable estrogen receptor (ER) degrader (SERD) with an EC₅₀ of 1.1 nM against ERα. ERα degrader 5 shows antitumor effect in vivo .

HY-138642

Vepdegestrant 2 Publications Verification ARV-471	PROTACs Estrogen Receptor/ERR	Cancer
Vepdegestrant (ARV-471) is an orally active PROTAC **estrogen receptor** degrader against breast cancer. Vepdegestrant is a hetero-bifunctional molecule that facilitates the interactions between estrogen receptor alpha and an intracellular E3 ligase complex. Vepdegestrant leads to the ubiquitylation and subsequent degradation of estrogen receptors via the proteasome. Vepdegestrant robustly degrades ER in ER-positive breast cancer cell lines with a half-maximal degradation concentration (DC₅₀) of about 2 nM .

HY-161692

ERα degrader 8	Estrogen Receptor/ERR	Cancer
ERα degrader 8 (Compound 18j) is a selective **Estrogen Receptor degrader. ERα degrader 8 is degrader to MCF-7 cells with IC₅₀** value of 0.15 μM .

HY-138642A

(Rac)-Vepdegestrant (Rac)-ARV-471	Estrogen Receptor/ERR PROTACs	Cancer
(Rac)-Vepdegestrant is the isomer of Vepdegestrant (HY-138642). Vepdegestrant ((R)-Lavandulol) is an orally active PROTAC **estrogen receptor** degrader against breast cancer. Vepdegestrant is a hetero-bifunctional molecule that facilitates the interactions between estrogen receptor alpha and an intracellular E3 ligase complex. Vepdegestrant leads to the ubiquitylation and subsequent degradation of estrogen receptors via the proteasome. Vepdegestrant robustly degrades ER in ER-positive breast cancer cell lines with a half-maximal degradation concentration (DC₅₀) of about 2 nM .

HY-143226

DK1	Estrogen Receptor/ERR	Metabolic Disease
DK1 is a potent modulator of **estrogen related receptor*. DK1 has an ability in reducing blood glucose, and impacts the activity of ERRα receptor*. DK1 has the potential for the research of diabetes .

HY-N6710S

α-Zearalenol-d4	Isotope-Labeled Compounds Estrogen Receptor/ERR	Inflammation/Immunology
α-Zearalenol-d4 is a deuterated labeled α-Zearalenol . α-Zearalenol is a Mycotoxin with high affinity for the estrogen receptors (ER), α-Zearalenol is the derivative of zearalenone (ZEN), causes reproductive disorders in animals, due to its xenoestrogenic effects .

HY-126109

(±)-8-Prenylnaringenin	Estrogen Receptor/ERR Apoptosis	Metabolic Disease Endocrinology Cancer
(±)-8-Prenylnaringenin, a natural prenylated flavonoid, is a potent phytoestrogen. (±)-8-Prenylnaringenin is an orally active selective estrogen receptor modulator (SERM) (Estrogen *Receptor/ERR) that inhibits ERα* and ERβ with IC₅₀s of 57 nM and 68 nM, respectively. (±)-8-Prenylnaringenin has anticancer effects, and can be used for osteoporosis research .

HY-144733

ERα antagonist 1	Estrogen Receptor/ERR Apoptosis	Cancer
ERα antagonist 1 (Compound 19d) is a potent, selective, covalent estrogen receptor α (ERα) antagonist. ERα antagonist 1 induces apoptosis and cell cycle G0/G1 phase arrest in MCF-7 cells .

HY-N6710R

α-Zearalenol (Standard)	Estrogen Receptor/ERR	Inflammation/Immunology
α-Zearalenol (Standard) is the analytical standard of α-Zearalenol. This product is intended for research and analytical applications. α-Zearalenol is a Mycotoxin with high affinity for the estrogen receptors (ER), α-Zearalenol is the derivative of zearalenone (ZEN), causes reproductive disorders in animals, due to its xenoestrogenic effects .

HY-N0233

Bavachin 5+ Cited Publications Corylifolin	Estrogen Receptor/ERR	Cancer
Bavachin, a flavonoid first isolated from seeds of P. corylifolia, acts as a phytoestrogen that activates the estrogen receptors ERα and ERβ with EC₅₀s of 320 and 680 nM, respectively.

HY-N4121

Isocurcumenol 1 Publications Verification	Estrogen Receptor/ERR Apoptosis	Cancer
Isocurcumenol, an estrogen receptor alpha (ERα) inhibitor isolated from Curcuma zedoaria Rhizomes, possesses anti-tumor acticity, with IC₅₀ values of 99.1μg/mL and 178.2 μg/mL in DLA and KB cells, respectively .

HY-112100

PROTAC ERα Degrader-5	PROTAC-Linker Conjugates for PAC Estrogen Receptor/ERR	Cancer
PROTAC ERα Degrader-5 (compound LP2) consists an ADC linker and a PROTAC, whcih can be conjugated to an antibody to form PACs. PROTAC ERα Degrader-5 conjugated to an antibody is a more marked estrogen receptor-alpha (ERα) degrader compared to PROTAC (without Ab) .

Cat. No.	Product Name	Type

HY-N0322

Cholesterol

30+ Cited Publications

Drug Delivery

Cholesterol is the major sterol in mammals. It is making up 20-25% of structural component of the plasma membrane. Plasma membranes are highly permeable to water but relatively impermeable to ions and protons. Cholesterol plays an important role in determining the fluidity and permeability characteristics of the membrane as well as the function of both the transporters and signaling proteins . Cholesterol is also an endogenous estrogen-related receptor α (ERRα) agonist .

HY-N0322A

Cholesterol (Water Soluble)

30+ Cited Publications

Drug Delivery

Cholesterol Water Soluble is a major sterol in mammals, constituting 20-25% of the structural composition of the plasma membrane. The plasma membrane is highly permeable to water but relatively impermeable to ions and protons. Cholesterol Water Soluble plays an important role in determining the fluidity and permeability characteristics of membranes and the function of transporters and signaling proteins. Cholesterol Water Soluble is also an endogenous estrogen-related receptor alpha (ERRα) agonist. Cholesterol Water Soluble can be used to study the effects of cholesterol on potassium currents in inner hair cells .

Cat. No.	Product Name	Target	Research Area

HY-P10393

ERα17p ERα (295-311)	Apoptosis	Cancer
ERα17p (ERα 295-311) is the epitope of the CaM binding site on the estrogen receptor α (ER), which interacts with calmodulin (CaM) in a calcium-dependent manner. ERα17p regulates the migration of cancer cells MCF-7, SK-BR-3, T47D, and MDA-MB-231 through Rho/ROCK and PI3K/Akt signaling pathways. ERα17p inhibits proliferations of breast cancer cells, induces apoptosis, and inhibits tumor growth in mouse models .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N2448

Lindleyin	Classification of Application Fields Rheum palmatum L. Polygonaceae Source classification Phenols Polyphenols Plants Disease Research Fields Endocrinology	Estrogen Receptor/ERR
Lindleyin, isolated from Rhei rhizoma, mediates hormonal effects through estrogen receptors. Lindleyin binds to ERα with estrogenic activity .

HY-14650

DHEA 25+ Cited Publications Prasterone; Dehydroisoandrosterone; Dehydroepiandrosterone	Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Steroids Cancer	Androgen Receptor Endogenous Metabolite
DHEA (Prasterone) is one of the most abundant steroid hormones. DHEA (Prasterone) mediates its action via multiple signaling pathways involving specific membrane receptors and via transformation into androgen and estrogen derivatives (e.g., androgens, estrogens, 7α and 7β DHEA, and 7α and 7β epiandrosterone derivatives) acting through their specific receptors.

HY-125703

Ferutinin	Viguiera dentata (Cav.) Spreng. Infection Structural Classification Classification of Application Fields Terpenoids Sesquiterpenes Source classification Umbelliferae Plants Disease Research Fields Endocrinology Cancer	Estrogen Receptor/ERR Apoptosis
Ferutinin, a natural terpenoid compound, is an estrogen receptor ERα agonist and estrogen ERβ-receptor agonist/antagonist with IC₅₀s of 33.1 nM and 180.5 nM, respectively. Ferutinin acts as an electrogenic Ca ²⁺-ionophore that increases calcium permeability of lipid bilayer membranes, mitochondria. Ferutinin possesses estrogenic, antitumor, antibacterial and antiinflammatory activities .

HY-N0233

Bavachin 5+ Cited Publications Corylifolin	Structural Classification Flavonoids Classification of Application Fields Leguminosae Flavonones Source classification Phenols Polyphenols Psoralea corylifolia L. Plants Disease Research Fields Cancer	Estrogen Receptor/ERR
Bavachin, a flavonoid first isolated from seeds of P. corylifolia, acts as a phytoestrogen that activates the estrogen receptors ERα and ERβ with EC₅₀s of 320 and 680 nM, respectively.

HY-N4121

Isocurcumenol 1 Publications Verification	Structural Classification other families Classification of Application Fields Terpenoids Sesquiterpenes Source classification Plants Disease Research Fields Cancer	Estrogen Receptor/ERR Apoptosis
Isocurcumenol, an estrogen receptor alpha (ERα) inhibitor isolated from Curcuma zedoaria Rhizomes, possesses anti-tumor acticity, with IC₅₀ values of 99.1μg/mL and 178.2 μg/mL in DLA and KB cells, respectively .

HY-B0412

Estriol 4 Publications Verification Oestriol	Structural Classification Monophenols Immune System Disorder Classification of Application Fields Source classification Disease markers Phenols Endocrine diseases Endogenous metabolite Disease Research Fields Steroids Cancer	Estrogen Receptor/ERR Endogenous Metabolite
Estriol (Oestriol), an orally active estrogen, is a ERα and ERβ agonist. Estriol is a potent GPR30 antagonist in estrogen receptor-negative breast cancer cells. Estriol can ameliorate disease severity through immunomodulatory mechanisms that decrease tissue inflammation. Estriol has powerful proconvulsant effects .

HY-N0835

(20S)-Protopanaxatriol 20(S)-APPT; g-PPT	Panax ginseng C. A. Meyer Cardiovascular Disease Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Plants Disease Research Fields Araliaceae	Glucocorticoid Receptor Estrogen Receptor/ERR LXR Apoptosis
(20S)-Protopanaxatriol is a metabolite of ginsenoside. (20S)-Protopanaxatriol works through the *glucocorticoid receptor* (GR)** and estrogen receptor (ER), and is also a LXRα inhibitor. (20S)-Protopanaxatriol shows a broad spectrum of antitumor effects .

HY-14590

Kaempferol Maximum Cited Publications 35 Publications Verification Kempferol; Robigenin	Flavonols Structural Classification Classification of Application Fields Anti-aging Source classification Plants Endogenous metabolite Human Gut Microbiota Metabolites Flavonoids Microorganisms other families Sunscreen Phenols Polyphenols Cosmetic Research Disease Research Fields Cancer	Estrogen Receptor/ERR Autophagy Mitophagy Apoptosis HIV Parasite Endogenous Metabolite
Kaempferol (Kempferol), a flavonoid found in many edible plants, inhibits estrogen receptor α expression in breast cancer cells and induces apoptosis in glioblastoma cells and lung cancer cells by activation of MEK-MAPK. Kaempferol can be uesd for the research of breast cancer .

HY-N0322

Cholesterol 30+ Cited Publications	Structural Classification Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Steroids Cancer	Liposome Estrogen Receptor/ERR Endogenous Metabolite Bacterial
Cholesterol is the major sterol in mammals. It is making up 20-25% of structural component of the plasma membrane. Plasma membranes are highly permeable to water but relatively impermeable to ions and protons. Cholesterol plays an important role in determining the fluidity and permeability characteristics of the membrane as well as the function of both the transporters and signaling proteins . Cholesterol is also an endogenous estrogen-related receptor α (ERRα) agonist .

HY-N0233R

Bavachin (Standard)	Structural Classification Flavonoids Leguminosae Flavonones Source classification Phenols Polyphenols Psoralea corylifolia L. Plants	Estrogen Receptor/ERR
Bavachin (Standard) is the analytical standard of Bavachin. This product is intended for research and analytical applications. Bavachin, a flavonoid first isolated from seeds of P. corylifolia, acts as a phytoestrogen that activates the estrogen receptors ERα and ERβ with EC50s of 320 and 680 nM, respectively.

HY-N0835R

(20S)-Protopanaxatriol (Standard)	Panax ginseng C. A. Meyer Triterpenes Structural Classification Terpenoids Source classification Plants Araliaceae	Glucocorticoid Receptor Estrogen Receptor/ERR LXR Apoptosis
(20S)-Protopanaxatriol (Standard) is the analytical standard of (20S)-Protopanaxatriol. This product is intended for research and analytical applications. (20S)-Protopanaxatriol is a metabolite of ginsenoside. (20S)-Protopanaxatriol works through the glucocorticoid receptor (GR) and estrogen receptor (ER), and is also a LXRα inhibitor. (20S)-Protopanaxatriol shows a broad spectrum of antitumor effects .

HY-N0322R

Cholesterol (Standard) 30+ Cited Publications	Structural Classification Classification of Application Fields Anti-aging Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Steroids Cancer	Liposome Estrogen Receptor/ERR Endogenous Metabolite Bacterial
Cholesterol (Standard) is the analytical standard of Cholesterol. This product is intended for research and analytical applications. Cholesterol is the major sterol in mammals. It is making up 20-25% of structural component of the plasma membrane. Plasma membranes are highly permeable to water but relatively impermeable to ions and protons. Cholesterol plays an important role in determining the fluidity and permeability characteristics of the membrane as well as the function of both the transporters and signaling proteins . Cholesterol is also an endogenous estrogen-related receptor α (ERRα) agonist .

HY-14590R

Kaempferol (Standard) Kempferol(Standard); Robigenin (Standard)	Structural Classification Classification of Application Fields Anti-aging Source classification Plants Endogenous metabolite Human Gut Microbiota Metabolites Flavonoids other families Sunscreen Phenols Cosmetic Research Disease Research Fields Cancer	Estrogen Receptor/ERR Autophagy Mitophagy Apoptosis HIV Parasite Endogenous Metabolite
Kaempferol (Standard) is the analytical standard of Kaempferol. This product is intended for research and analytical applications. Kaempferol (Kempferol), a flavonoid found in many edible plants, inhibits estrogen receptor α expression in breast cancer cells and induces apoptosis in glioblastoma cells and lung cancer cells by activation of MEK-MAPK. Kaempferol can be uesd for the research of breast cancer .

HY-N0322A

Cholesterol (Water Soluble) 30+ Cited Publications	Structural Classification Classification of Application Fields Source classification Other Diseases Endogenous metabolite Disease Research Fields Steroids	Liposome
Cholesterol Water Soluble is a major sterol in mammals, constituting 20-25% of the structural composition of the plasma membrane. The plasma membrane is highly permeable to water but relatively impermeable to ions and protons. Cholesterol Water Soluble plays an important role in determining the fluidity and permeability characteristics of membranes and the function of transporters and signaling proteins. Cholesterol Water Soluble is also an endogenous estrogen-related receptor alpha (ERRα) agonist. Cholesterol Water Soluble can be used to study the effects of cholesterol on potassium currents in inner hair cells .

Species:	Human (2)
Tag:	His (2)
Source:	P. pastoris (1) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P70248

	ER alpha/ESR1 Protein, Human (His) 1 Publications Verification rHuestrogen receptor/ER alpha, His; estrogen receptor; ER; ER-Alpha; Estradiol receptor; Nuclear receptor Subfamily 3 Group A Member 1; ESR1; ESR; NR3A1	Human	E. coli
	The ER α/ESR1 protein is a nuclear receptor that plays a critical regulatory role in gene expression, affecting cell proliferation and differentiation. Ligand-dependent transactivation involves binding of homodimers to estrogen response elements or association with transcription factors. ER alpha/ESR1 Protein, Human (His) is the recombinant human-derived ER alpha/ESR1 protein, expressed by E. coli , with N-6*His labeled tag.

HY-P701106

	ER alpha/ESR1 Protein, Human (P. pastoris, N-His) rHuestrogen receptor/ER alpha, His; estrogen receptor; ER; ER-Alpha; Estradiol receptor; Nuclear receptor Subfamily 3 Group A Member 1; ESR1; ESR; NR3A1	Human	P. pastoris
	The ER α/ESR1 protein is a nuclear receptor that plays a critical regulatory role in gene expression, affecting cell proliferation and differentiation. Ligand-dependent transactivation involves binding of homodimers to estrogen response elements or association with transcription factors. ER alpha/ESR1 Protein, Human (P. pastoris, N-His) is the recombinant human-derived ER alpha/ESR1 protein, expressed by P. pastoris , with N-6*His labeled tag.

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HY-N0322S

Cholesterol-d7

Cholesterol-d₇ is the deuterium labeled Cholesterol. Cholesterol is the major sterol in mammals. It is making up 20-25% of structural component of the plasma membrane. Plasma membranes are highly permeable to water but relatively impermeable to ions and protons. Cholesterol plays an important role in determining the fluidity and permeability characteristics of the membrane as well as the function of both the transporters and signaling proteins . Cholesterol is also an endogenous estrogen-related receptor α (ERRα) agonist .

HY-N0322S4

Cholesterol-13C3

Cholesterol- ¹³C₃ is the ¹³C-labeled Cholesterol. Cholesterol is the major sterol in mammals. It is making up 20-25% of structural component of the plasma membrane. Plasma membranes are highly permeable to water but relatively impermeable to ions and protons. Cholesterol plays an important role in determining the fluidity and permeability characteristics of the membrane as well as the function of both the transporters and signaling proteins . Cholesterol is also an endogenous estrogen-related receptor α (ERRα) agonist .

HY-B0723S

Ospemifene D4
Ospemifene-d₄ is a deuterium labeled Ospemifene. Ospemifene is a selective and orally active estrogen receptor modulator for the prevention of osteoporosis with IC50 values of 827 nM and 1633 nM for estrogen receptor α (ERα) and ERβ, respectively. Ospemifene has bone-sparing, antitumor, and cholesterol-lowering effects[1][2].

HY-N6710S

α-Zearalenol-d4
α-Zearalenol-d4 is a deuterated labeled α-Zearalenol . α-Zearalenol is a Mycotoxin with high affinity for the estrogen receptors (ER), α-Zearalenol is the derivative of zearalenone (ZEN), causes reproductive disorders in animals, due to its xenoestrogenic effects .

HY-19822S3

Elacestrant-d6
Elacestrant-d₆ (RAD1901-d₆) is a deuterated labeled Elacestrant (HY-19822). Elacestrant is a selective estrogen receptor (estrogen *receptor, ER) degrader (SERD) with oral activity, with IC₅₀* values of 48 and 870 nM for ERα and ERβ, respectively. Elacestrant can also effectively inhibit the growth of ER ⁺ breast cancer cell lines both in vitro and in vivo.

HY-19822S

Elacestrant-d4
Elacestrant-d₄ (RAD1901-d₄) is a deuterated labeled Elacestrant (HY-19822). Elacestrant (RAD1901) is a selective estrogen receptor (estrogen *receptor, ER) degrader (SERD) with oral activity, with IC₅₀* values of 48 and 870 nM for ERα and ERβ, respectively. Elacestrant can also effectively inhibit the growth of ER ⁺ breast cancer cell lines both in vitro and in vivo.

HY-19822S1

Elacestrant-d4-1
Elacestrant-d₄-1 is the deuterium labeled Elacestrant (HY-19822). Elacestrant is an orally available and selective estrogen receptor degrader (SERD) with IC₅₀s of 48 and 870 nM for ERα and ERβ, respectively .

HY-19822S2

Elacestrant-d10
Elacestrant-d₁₀ is the deuterium labeled of Elacestrant (HY-19822). Elacestrant is an orally available and selective **estrogen receptor degrader (SERD) with IC₅₀**s of 48 and 870 nM for ERα and ERβ, respectively. Elacestrant also inhibits growth of ER ⁺ breast cancer cell lines in vitro and in vivo .

HY-N0322S7

Cholesterol-d1

Cholesterol-d is the deuterium labeled Cholesterol. Cholesterol is the major sterol in mammals. It is making up 20-25% of structural component of the plasma membrane. Plasma membranes are highly permeable to water but relatively impermeable to ions and protons. Cholesterol plays an important role in determining the fluidity and permeability characteristics of the membrane as well as the function of both the transporters and signaling proteins . Cholesterol is also an endogenous estrogen-related receptor α (ERRα) agonist .

HY-N0322S2

Cholesterol-d6-1

Cholesterol-d₆-1 is the deuterium labeled Cholesterol. Cholesterol is the major sterol in mammals. It is making up 20-25% of structural component of the plasma membrane. Plasma membranes are highly permeable to water but relatively impermeable to ions and protons. Cholesterol plays an important role in determining the fluidity and permeability characteristics of the membrane as well as the function of both the transporters and signaling proteins . Cholesterol is also an endogenous estrogen-related receptor α (ERRα) agonist .

HY-N0322S3

Cholesterol-13C5

Cholesterol- ¹³C₅ is the ¹³C-labeled Cholesterol. Cholesterol is the major sterol in mammals. It is making up 20-25% of structural component of the plasma membrane. Plasma membranes are highly permeable to water but relatively impermeable to ions and protons. Cholesterol plays an important role in determining the fluidity and permeability characteristics of the membrane as well as the function of both the transporters and signaling proteins . Cholesterol is also an endogenous estrogen-related receptor α (ERRα) agonist .

HY-N0322S5

Cholesterol-13C2

Cholesterol- ¹³C₂ is the ¹³C labeled Cholesterol. Cholesterol is the major sterol in mammals. It is making up 20-25% of structural component of the plasma membrane. Plasma membranes are highly permeable to water but relatively impermeable to ions and protons. Cholesterol plays an important role in determining the fluidity and permeability characteristics of the membrane as well as the function of both the transporters and signaling proteins . Cholesterol is also an endogenous estrogen-related receptor α (ERRα) agonist .

HY-N0322S1

Cholesterol-d6

Cholesterol-d₆ is the deuterium labeled Cholesterol. Cholesterol is the major sterol in mammals. It is making up 20-25% of structural component of the plasma membrane. Plasma membranes are highly permeable to water but relatively impermeable to ions and protons. Cholesterol plays an important role in determining the fluidity and permeability characteristics of the membrane as well as the function of both the transporters and signaling proteins . Cholesterol is also an endogenous estrogen-related receptor α (ERRα) agonist .

HY-N0322S6

Cholesterol-d4

Cholesterol-d₄ is deuterium labeled Cholesterol. Cholesterol is the major sterol in mammals. It is making up 20-25% of structural component of the plasma membrane. Plasma membranes are highly permeable to water but relatively impermeable to ions and protons. Cholesterol plays an important role in determining the fluidity and permeability characteristics of the membrane as well as the function of both the transporters and signaling proteins . Cholesterol is also an endogenous estrogen-related receptor α (ERRα) agonist .

HY-N0322S8

Cholesterol-18O

Cholesterol- ¹⁸O is the deuterium labeled Cholesterol. Cholesterol is the major sterol in mammals. It is making up 20-25% of structural component of the plasma membrane. Plasma membranes are highly permeable to water but relatively impermeable to ions and protons. Cholesterol plays an important role in determining the fluidity and permeability characteristics of the membrane as well as the function of both the transporters and signaling proteins . Cholesterol is also an endogenous estrogen-related receptor α (ERRα) agonist .

HY-A0031S

Bazedoxifene-d4

Bazedoxifene-d₄ is deuterium labeled Bazedoxifene. Bazedoxifene (TSE-424) is an oral, BBB-penetrant nonsteroidal selective estrogen receptor modulator (SERM), with IC50s of 23 nM and 99 nM for ERα and ERβ, respectively. Bazedoxifene can be used for the research of osteoporosis. Bazedoxifene also acts as an inhibitor of IL-6/GP130 protein-protein interactions and can be used for the research of pancreatic cancer[1][2].

HY-A0031S2

Bazedoxifene-d4 acetate

Bazedoxifene-d₄ (acetate) is the deuterium labeled Bazedoxifene[1]. Bazedoxifene (TSE-424) is an oral, BBB-penetrant nonsteroidal selective estrogen receptor modulator (SERM), with IC50s of 23 nM and 99 nM for ERα and ERβ, respectively. Bazedoxifene can be used for the research of osteoporosis. Bazedoxifene also acts as an inhibitor of IL-6/GP130 protein-protein interactions and can be used for the research of pancreatic cancer[2][3].

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P80663

	Estrogen Receptor alpha Antibody ESR1; Era; Eralpha; estrogen receptor; Estradiol receptor; ER-alpha; estrogen receptor 1; NR3A1; ER; ESR; ESRA; estrogen receptor alpha	WB, IHC-F, IHC-P, ICC/IF, IP, ChIP	Human
	Estrogen Receptor alpha Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 66 kDa, targeting to Estrogen Receptor alpha. It can be used for WB,IHC-F,IHC-P,ICC/IF,IP,ChIP assays with tag free, in the background of Human.

HY-P80662

	Estrogen Receptor alpha Antibody (YA768) ESR1; Era; Eralpha; estrogen receptor; Estradiol receptor; ER-alpha; estrogen receptor 1; NR3A1; ER; ESR; ESRA; estrogen receptor alpha	WB	Human, Mouse, Rat
	Estrogen Receptor alpha Antibody (YA768) is a non-conjugated and Mouse origined monoclonal antibody about 66 kDa, targeting to Estrogen Receptor alpha (6F11). It can be used for WB assays with tag free, in the background of Transfected.

HY-P82538

	ERR alpha Antibody (YA2283) ESRRA; ERRa; ERR1; HERR1; NR3B1; Steroid hormone receptor ERR1; ERR-alpha; ERRalpha; ESRL1; estrogen receptor-like 1; estrogen-related receptor alpha	WB, IP, FC	Human, Mouse, Rat
	ERR alpha Antibody (YA2283) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2283), targeting ERR alpha, with a predicted molecular weight of 46 kDa (observed band size: 50 kDa). ERR alpha Antibody (YA2283) can be used for WB, IP, FC experiment in human, mouse, rat background.

HY-P83728

	PGC1 alpha+beta Antibody (YA3458) LEM6 antibody; Ligand effect modulator 6 antibody; PERC antibody; Peroxisome proliferative activated receptor, gamma, coactivator 1 alpha antibody; Peroxisome proliferative activated receptor, gamma, coactivator 1 antibody; Peroxisome proliferator activated receptor gamma coactivator 1 alpha antibody; peroxisome proliferator-activated receptor gamma coactivator 1 beta antibody; Peroxisome proliferator-activated receptor gamma coactivator 1-alpha antibody; Peroxisome proliferator-activated receptor gamma coactivator 1-beta antibody; peroxisome proliferator-activated receptor gamma, coactivator 1 beta antibody; PGC 1 (alpha) antibody; PGC 1 alpha antibody; PGC 1v antibody; PGC-1(beta) antibody; PGC-1-alpha antibody; PGC-1-beta antibody; PGC-1-related estrogen receptor alpha coactivator antibody; PGC1 antibody; PGC1(alpha) antibody; PGC1A antibody; PGC1v antibody; PPAR gamma coactivator 1 alpha antibody; PPAR gamma coactivator 1 alpha 3 ligand effect modulator 6 antibody; PPAR gamma coactivator 1 antibody; PPAR gamma coactivator variant form antibody; PPAR gamma coactivator-1beta antibody; PPAR-gamma coactivator 1-alpha antibody; PPAR-gamma coactivator 1-beta antibody; PPARGC 1 alpha antibody; PPARGC-1-alpha antibody; PPARGC-1-beta antibody; PPARGC1 antibody; PPARGC1A antibody; Ppargc1b antibody; PRGC1_HUMAN antibody; PRGC2_HUMAN antibody	WB	Human, Mouse, Rat
	PGC1 alpha+beta Antibody (YA3458) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3458), targeting PGC1 alpha+beta , with a predicted molecular weight of 91/113 kDa (observed band size:110 kDa). PGC1 alpha+beta Antibody (YA3458) can be used for WB experiment in human, mouse, rat background.

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Cat. No.	Product Name		Classification

HY-139999

LCL-PEG3-N3		Azide
LCL-PEG3-N3 is a decoy oligonucleotide ligand for E3 ligase which can be used for developing chimeric molecules LCL-ER(dec), degrading the estrogen receptor . LCL-PEG3-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-139999A

LCL-PEG3-N3 hydrochloride		Azide
LCL-PEG3-N3 (hydrochloride) is a decoy oligonucleotide ligand for E3 ligase which can be used for developing chimeric molecules LCL-ER(dec), degrading the estrogen receptor . LCL-PEG3-N3 (hydrochloride) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

Cat. No.	Product Name		Classification

HY-N0322

Cholesterol 30+ Cited Publications		Emulsifiers
Cholesterol is the major sterol in mammals. It is making up 20-25% of structural component of the plasma membrane. Plasma membranes are highly permeable to water but relatively impermeable to ions and protons. Cholesterol plays an important role in determining the fluidity and permeability characteristics of the membrane as well as the function of both the transporters and signaling proteins . Cholesterol is also an endogenous estrogen-related receptor α (ERRα) agonist .

HY-N0322A

Cholesterol (Water Soluble) 30+ Cited Publications		Cholesterol
Cholesterol Water Soluble is a major sterol in mammals, constituting 20-25% of the structural composition of the plasma membrane. The plasma membrane is highly permeable to water but relatively impermeable to ions and protons. Cholesterol Water Soluble plays an important role in determining the fluidity and permeability characteristics of membranes and the function of transporters and signaling proteins. Cholesterol Water Soluble is also an endogenous estrogen-related receptor alpha (ERRα) agonist. Cholesterol Water Soluble can be used to study the effects of cholesterol on potassium currents in inner hair cells .

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estrogen receptor α

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