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Results for "

lipases

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Lipase (4) Acyltransferase (1) Androgen Receptor (1) Apoptosis (6) ATGL (3) Autophagy (2) Bacterial (7) Beta-lactamase (1) Biochemical Assay Reagents (7) Calcium Channel (1) Cannabinoid Receptor (2) Carboxylesterase (2) Cholinesterase (ChE) (1) COX (1) DAGL (8) Drug Metabolite (1) Endogenous Metabolite (24) FAAH (6) Fatty Acid Synthase (FASN) (3) Fluorescent Dye (7) Fungal (7) Glucosidase (1) Histamine Receptor (1) Isotope-Labeled Compounds (3) LPL Receptor (1) mAChR (1) MAGL (28) Melanocortin Receptor (2) MetAP (1) MMP (1) Phospholipase (3) Wnt (1)
By Research Areas:	Cancer (18) Cardiovascular Disease (3) Endocrinology (2) Infection (11) Inflammation/Immunology (17) Metabolic Disease (65) Neurological Disease (20)
Click Chemistry:	Alkynes (1)
Oligonucleotides:	Emulsifiers (1) Solubilizing Agents (1)

154

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Oligonucleotides

Targets Recommended: Lipase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-117095

4-Methylumbelliferyl oleate	Fluorescent Dye	Metabolic Disease
4-Methylumbelliferyl oleate is a fluorogenic substrate for acid and alkaline *lipases. 4-Methylumbelliferyl oleate is cleaved by lipases*, liberating 4-Methylumbelliferyl (Ex/Em=320/450 nm) .

HY-136562

N-Arachidonyl maleimide	MAGL	Metabolic Disease
N-Arachidonyl maleimide is a potent, irreversible inhibitor of monoacylglycerol lipase (MAGL) with an IC₅₀ value of 140 nM .

HY-138653

Lipase Substrate	Others	Metabolic Disease
Lipase Substrate is a substrate of lipase to detect activity .

HY-144375

*Monoacylglycerol lipase* inhibitor 1**	MAGL	Others
Monoacylglycerol lipase inhibitor 1 is a potent monoacylglycerol lipase inhibitor (compound 13) .

HY-157313

*Pancreatic lipase-IN-1*	Others	Metabolic Disease
Pancreatic lipase-IN-1 (compound 8) ia a pancreatic lipase inhibitor with the K_i of 1.288 ?μM .

HY-N12294

Ciwujianoside D2	Others	Metabolic Disease
Ciwujianoside D2, a saponin compound, can enhance pancreatic lipase activity in vitro .

HY-N12296

Ciwujianoside C4	Others	Metabolic Disease
Ciwujianoside C4, a saponin compound, can enhance pancreatic lipase activity in vitro .

HY-N12297

Ciwujianoside C2	Others	Others
Ciwujianoside C2 is a saponin, that can be isolated from the leaves of Acanthopanax senticosus. Ciwujianoside C2 enhances pancreatic lipase activity in vitro .

HY-N12292

Acanthopanaxoside A	Others	Metabolic Disease
Acanthopanaxoside A, a triterpenoid saponin, has pancreatic *lipase* inhibitory action .

HY-168032

MAGL-IN-18	MAGL	Inflammation/Immunology
MAGL-IN-18 (compound 118) is a potent *Monoacylglycerol lipase* (MAGL) inhibitor with an IC₅₀** of 0.03 nM .

HY-116583

Resorufin butyrate	Cholinesterase (ChE)	Metabolic Disease
Resorufin butyrate is a fluorogenic substrate for triglyceride lipases and cholinesterase (Ex=570 nm, Em=580 nm) .

HY-121517

URB754	Others	Neurological Disease
URB754 is a potent inhibitor of the endocannabinoid-deactivating enzyme monoacylglycerol lipase (MGL) with an IC₅₀ of 200 nM .

HY-153523

Hi 76-0079 NNC0076-0079; 76-0079	Others	Metabolic Disease
Hi 76-0079 (Compound 31) is a hormone-sensitive lipase (HSL) inhibitor with an IC₅₀ of 184 nM .

HY-E70277

Hexadecyl-CoA	ATGL	Metabolic Disease
Hexadecyl-CoA is a thioether analog of acyl-CoA that can inhibit adipose triglyceride lipase (ATGL) .

HY-N8362

1-Isomangostin	Others	Metabolic Disease
1-Isomangostin is an inhibitor of pancreatic lipase. 1-Isomangostin inhibits porcine pancreatic lipase with an IC₅₀ of 34.5 μM. 1-Isomangostin has anti-obesity activity .

HY-N12298

Ciwujianoside C1	Others	Others
Ciwujianoside C1 is a saponin, that can be isolated from the leaves of Acanthopanax senticosus. Ciwujianoside C1 inhibits pancreatic lipase activity in vitro .

HY-14471

Cetilistat ATL-962	Others	Metabolic Disease
Cetilistat (ATL-962), an inhibitor of pancreatic lipase, acts as an effective anti-obesity agent. Cetilistat inhibits rat and human pancreatic lipase activity with IC₅₀s of 54.8 nM, and 5.95 nM, respectively .

HY-136124

Cetilistat impurity 1	Drug Metabolite	Others
Cetilistat impurity 1 is an impurity of Cetilistat. Cetilistat, an inhibitor of pancreatic lipase, acts as an effective anti-obesity agent. Cetilistat inhibits rat and human pancreatic lipase activity with IC₅₀s of 54.8 nM, and 5.95 nM, respectively .

HY-126938

4-Methylumbelliferyl heptanoate	Others	Others
4-Methylumbelliferyl heptanoate is a potent fluorometric substrate of lipase .

HY-144809

*Pancreatic lipase/Carboxylesterase 1-IN-1*	Carboxylesterase	Metabolic Disease
Pancreatic lipase/Carboxylesterase 1-IN-1 (Compound 39) is a potent dual inhibitor of *pancreatic lipase* (PL) and human carboxylesterase 1A (hCES1A) with IC₅₀** values of 2.13 µM and 0.055 µM against PL and hCES1A .

HY-118653

SAR629	MAGL	Metabolic Disease
SAR629 is a potent *monoglyceride lipase* (MGL)** covalent inhibitor. SAR629 also inhibits 2-Arachidonoylglycerol (2-AG) degradation .

HY-14471R

Cetilistat (Standard)	Others	Metabolic Disease
Cetilistat (Standard) is the analytical standard of Cetilistat. This product is intended for research and analytical applications. Cetilistat (ATL-962), an inhibitor of pancreatic lipase, acts as an effective anti-obesity agent. Cetilistat inhibits rat and human pancreatic lipase activity with IC50s of 54.8 nM, and 5.95 nM, respectively .

HY-W099648

4-Methylumbelliferyl octanoate	Others	Others
4-Methylumbelliferyl octanoate is a octoate. 4-Methylumbelliferyl octanoate can be used as a s ubstrate of hog pancreatic lipase .

HY-123012A

Lubabegron fumarate LY-591281; LY-488756 fumarate	Androgen Receptor	Metabolic Disease
Lubabegron (LY-488756) fumarate is an antagonist of the adrenergic receptor (β-AR). Lubabegron fumarate can antagonize the stimulatory effects of β1-AR and β2-AR agonists on lipase respectively .

HY-Y1422B

Lipase (MS grade)	Endogenous Metabolite	Metabolic Disease
Lipase (MS grade) catalyzes the hydrolysis of triacylglycerols to release long-chain fatty acids in a site-specific manner.

HY-131999

3,4,5-Trihydroxycinnamic acid decyl ester	Others	Metabolic Disease
3,4,5-Trihydroxycinnamic acid decyl ester is an excellent inhibitor of lipid absorption and accumulation, with anti-obesity properties. 3,4,5-Trihydroxycinnamic acid decyl ester is a pancreatic lipase inhibitor, with an EC₅₀ of approximately 0.9 μM .

HY-N10606

Uvagrandol	Glucosidase	Metabolic Disease
Uvagrandol potently inhibits α-glucosidase and porcine lipase (IC₅₀: 15.2 μM, 11.2 μM respectively). Uvagrandol can be used in the research of Type 2 diabetes and obesity .

HY-114754

BemPPOX	Others	Metabolic Disease
BemPPOX is an orally active, potent *dog gastric lipase* (DGL)** inhibitor with X_l50 (the inhibitor molar excess leading to 50% lipase inhibition) of 0.5. BemPPOX is also a good inhibitor of GPLRP2 (x_l50=0.64). BemPPOX efficiently regulates the gastrointestinal lipolysis and slows down the overall lipolysis process in rats. BemPPOX has the potential for obesity research .

HY-135297

Mono-and diglycerides	Biochemical Assay Reagents	Others
Mono-and diglycerides is formed by triglycerides being broken down by pancreatic lipase in the gastrointestinal lumen. Mono-and diglycerides is a food additive used as a nonionic emulsifier and mainly present in food fats .

HY-N11999

5,4'-Dihydroxy-3,4,3'-trimethoxybibenzyl	Others	Others
5,4'-Dihydroxy-3,4,3'-trimethoxybibenzyl (compound 8) can be isolated from Dendrobium infundibulum (D. infundibulum). 5,4'-Dihydroxy-3,4,3'-trimethoxybibenzyl has no inhibitory activity against α-glucosidase and pancreatic lipase .

HY-N3797A

Echitamine chloride Ditaine chloride	Apoptosis	Cancer
Echitamine (Ditaine) chloride is the major monoterpene indole alkaloid present in Alstonia scholaris with potent anti-tumour activity. Echitamine chloride induces DNA fragmentation and cells apoptosis. Echitamine chloride inhibits pancreatic lipase with an IC₅₀ of 10.92 μM .

HY-N8989

(1,5E,11E)-Tridecatriene-7,9-diyne-3,4-diacetate	Others	Metabolic Disease
(1,5E,11E)-Tridecatriene-7,9-diyne-3,4-diacetate, isolated from the ethanol extract of Atractylodes lancea rhizome, displays significant lipase inhibition with an IC₅₀ value of 23.9 µg/mL. Antiobesity Effect .

HY-118481

H-Pro-Glu-OH	Others	Infection
H-Pro-Glu-OH is a protein secreted by pathogenic mycobacteria through the Type VII secretion system. H-Pro-Glu-OH targets LipY lipases to the cell Surface via the ESX-5 Pathway .

HY-W010947

4-Methylumbelliferyl palmitate	Fluorescent Dye	Inflammation/Immunology
4-Methylumbelliferyl palmitate is an excellent fluorophore for measuring acid lipase in human leukocytes. Acidity and solvent have important influence on its fluorescence. 4-Methylumbelliferyl palmitate exists mainly as neutral molecular form which can be produced strong fluorescence at 445 nm in near neutral aqueous solutions, and exist mainly as anion form which can be produced stronger fluorescence at 445 nm in weak alkaline solutions .

HY-157041

MAGL-IN-10	MAGL	Cancer
MAGL-IN-10 is areversible monoacylglycerol lipase (MAGL) inhibitor with very good ADME properties and low in vivo toxicity.MAGL-IN-10 can be used for the research ofcancer, neurological disorders and inflammatory pathologies .

HY-117549

Ibrolipim NO-1886	Others	Cardiovascular Disease
Ibrolipim (NO-1886) is an orally active *lipoprotein lipase* (LPL)**-promoting agent. Ibrolipim decreases plasma triglycerides, increases high-density lipoprotein cholesterol levels. Ibrolipim has renoprotective and hypolipidemic effects .

HY-B0218

Orlistat 10+ Cited Publications Tetrahydrolipstatin; Ro-18-0647	Fatty Acid Synthase (FASN) Apoptosis	Metabolic Disease Cancer
Orlistat (Tetrahydrolipstatin) is a well-known irreversible inhibitor of pancreatic and gastric *lipases. Orlistat is also an inhibitor of fatty acid synthase (FASN*), is used orally for long-term research of obesity . Anti-atherosclerotic effect .

HY-18522

AA26-9	Phospholipase	Metabolic Disease
AA26-9 is a potent and broad spectrum serine hydrolase inhibitor. AA26-9 targets included serine peptidases, lipases, amidases, esterases, and thioesterases. AA26-9 shows inhibitory activity against approximately 1/3 of the 40+ serine hydrolases detected in immortalized T cell lines .

HY-N13198

4-(4-Hydroxyphenyl)-2-butanone 4'-O-β-D-(2-O-galloyl-6-O-cinnamoyl)glucopyranoside	Endogenous Metabolite	Metabolic Disease
4-(4-Hydroxyphenyl)-2-butanone 4'-O-β-D-(2-O-galloyl-6-O-cinnamoyl)glucopyranoside is a pancreatic lipase inhibitor, with an IC₅₀ value of 2.91 μM. 4-(4-Hydroxyphenyl)-2-butanone 4'-O-β-D-(2-O-galloyl-6-O-cinnamoyl)glucopyranoside can effectively reduce lipid absorption and regulate obesity-related metabolic disorders, making it useful for research on obesity .

HY-107416

RHC 80267 U-57908	DAGL Acyltransferase mAChR COX Phospholipase	Neurological Disease Metabolic Disease
RHC 80267 (U-57908) is a potent and selective inhibitor of *diacylglycerol lipase* (DAGL) (with IC₅₀ of 4 μM in canine platelets). RHC-80267 inhibits cholinesterase activity with an IC₅₀ of 4 μM, thereby enhancing the relaxation evoked by acetylcholine. RHC 80267 also inhibits COX and the hydrolysis of phosphatidylcholine (PC)** .

HY-Y1422K

Lipase PS-IM	Others	Others
Lipase PS-IM is an immobilized lipase derived from Burkholderiacepacia .

HY-Y1422H

Lipase AYS	Others	Others
Lipase AYS is an immobilized lipase derived from Candida rugosa .

HY-Y1422A

Lipase, Human Pancreas Pancreatic Triacylglycerol Lipase, PL, PTL, Pancreatic Lipase	Others	Others
Lipase, Human Pancreas (Pancreatic Triacylglycerol Lipase, PL, PTL, Pancreatic Lipase) is a biological material or organic compound that can be used in life science research .

HY-112911

*Endothelial lipase* inhibitor-1**	Others	Cardiovascular Disease
Endothelial lipase inhibitor-1 is a potent endothelial lipase inhibitor with an IC₅₀ of 49 nM.

HY-132310

MAGL-IN-4	MAGL	Neurological Disease
MAGL-IN-4 is an orally active, selective and reversible *monoacylglycerol lipase* (MAGL) inhibitor with an IC₅₀** of 6.2 nM. MAGL-IN-4 can penetrate the blood-brain barrier (BBB). MAGL-IN-4 enhances endocannabinoid signaling mostly by the increase in the level of 2-AG via selective MAGL inhibition in the brain .

HY-E70307

Lipase, Porcine Pancreas	Endogenous Metabolite	Others
Lipase, Porcine Pancreas (PPL) is a porcine pancreas lipase that catalyzes the hydrolysis of mustard oil. The catalytic activity of Lipase, Porcine Pancreas may also be affected by surfactants such as Span, Tween and Triton. For example, 0.02 M sorbose monooleate (Span 80), 0.01 M Tween 80, and 0.01 M Triton X-100 inhibited Lipase and Porcine Pancreas free lipase catalytic rates to 75%, 84%, and 93% respectively .

HY-119283

MAGL-IN-5 1 Publications Verification CAY10499	MAGL FAAH	Metabolic Disease
MAGL-IN-5 (CAY10499) is a non-selective lipase inhibitor with IC₅₀ values of 144, 90, and 14 nM for human recombinant monoacylglycerol lipase(MAGL),hormone sensitive lipase(HSL), and fatty acid amide hydrolase(FAAH) respectively .

HY-124314

LEI-106	DAGL MAGL	Metabolic Disease
LEI-106 is a potent, dual *sn-1-Diacylglycerol lipase* α (DAGL-α)/ABHD6 inhibitor with an IC₅₀ of 18 nM for DAGL-α and a K_i** of 0.8 μM for ABHD6. LEI-106 inhibits the hydrolysis of [ ¹⁴C]-sn-1-oleoyl-2-arachidonoyl-glycerol, the natural substrate of DAGL-α, with a K_i of 0.7 μM .

HY-W283889

Blue caprate	Biochemical Assay Reagents	Others
Blue caprate is a chromogenic enzyme substrate typically used to detect lipase activity. It is hydrolyzed by lipase to produce a blue-purple product (biosynth: EB04034).

HY-P2752

*Lipoprotein lipase, Pseudomonas sp* LPL	Endogenous Metabolite	Metabolic Disease Cancer
Lipoprotein lipase, Pseudomonas sp (LPL) is a multifunctional enzyme from adipose tissue, heart and skeletal muscle, islets and macrophages. Lipoprotein lipase promotes normal lipoprotein metabolism, delivery and utilization of tissue-specific substrates. Lipoprotein lipase catalyzes the rate-limiting step of lipids in blood circulation .

Cat. No.	Product Name	Type

HY-116583

Resorufin butyrate	Fluorescent Dyes/Probes
Resorufin butyrate is a fluorogenic substrate for triglyceride lipases and cholinesterase (Ex=570 nm, Em=580 nm) .

HY-W010947

4-Methylumbelliferyl palmitate

Fluorescent Dyes/Probes

4-Methylumbelliferyl palmitate is an excellent fluorophore for measuring acid lipase in human leukocytes. Acidity and solvent have important influence on its fluorescence. 4-Methylumbelliferyl palmitate exists mainly as neutral molecular form which can be produced strong fluorescence at 445 nm in near neutral aqueous solutions, and exist mainly as anion form which can be produced stronger fluorescence at 445 nm in weak alkaline solutions .

HY-114879

DDAO 1 Publications Verification	Fluorescent Dyes/Probes
DDAO is a promising near-infrared (NIR) red fluorescent probewith tunable excitation wavelength (600-650nm) and longemission wavelength(λem=656nm). DDAO can de desiged for detection of the activities of different enzymes such asβ-galactosidase,sulfatase, proteinphosphatase2A,carboxylesterase 2, humanalbumin andesterases .

HY-D0047

5-CFDA 3 Publications Verification 5-Carboxyfluorescein diacetate	Fluorescent Dyes/Probes
5-CFDA is a common aliphatic luciferin-line organism. CFDA conducts free diffusion into cells, and then it is hydrolyzed into carboxyl fluorescein (CF) by intracellular non-specific lipase. CF containing portion contains an additional negative charge so that it is better retained in cells, compared to fluorescein dyes .

HY-D0721

6-CFDA 6-Carboxyfluorescein diacetate	Fluorescent Dyes/Probes
6-CFDA is a common aliphatic luciferin-line organism. CFDA conducts free diffusion into cells, and then it is hydrolyzed into carboxyl fluorescein (CF) by intracellular non-specific lipase. CF containing portion contains an additional negative charge so that it is better retained in cells, compared to fluorescein dyes .

HY-D0722

5(6)-CFDA 5 Publications Verification 5-(6)-Carboxyfluorescein diacetate; CFDA	Fluorescent Dyes/Probes
5(6)-CFDA is a common aliphatic luciferin-line organism. CFDA conducts free diffusion into cells, and then it is hydrolyzed into carboxyl fluorescein (CF) by intracellular non-specific lipase. CF containing portion contains an additional negative charge so that it is better retained in cells, compared to fluorescein dyes .

HY-W013168

4-Nitrophenyl palmitate

4-Nitrophenyl hexadecanoate; p-Nitrophenyl Palmitate; pNpp

Dyes

4-Nitrophenyl palmitate (4-Nitrophenyl hexadecanoate; p-Nitrophenyl Palmitate) is a colorimetric lipase and esterase substrate. Upon enzymatic hydrolysis of 4-Nitrophenyl palmitate, 4-nitrophenol is released, which can be quantified by colorimetric detection at 410 nm as a measure of enzyme activity. 4-Nitrophenyl palmitate has been used to characterize the activity of various bacterial and mammalian enzymes, including Burkholderia and porcine pancreatic lipase.

HY-150978

DDAO-C6	Fluorescent Dyes/Probes
DDAO-C6 is a cridone ester derivative, highly specific fluorescence for detecting human serum albumin (HSA). DDAO-C6 acts as an enzymatic activatable near-infrared fluorescent probe in visually sensing endogenous lipase from gut microbes (Ex/Em=600/658 nm) .

Cat. No.	Product Name	Type

HY-W099563

4-Nitrophenyl stearate

Enzyme Substrates

4-Nitrophenyl stearate, which is an ester formed by the condensation of stearic acid and 4-nitrophenol, is commonly used as a substrate for enzymatic assays, where the hydrolysis of ester bonds by esterase and lipase can be measured by absorbance or ratio In addition, 4-Nitrophenyl stearate has been used as a model compound to study the enzymatic activity and selectivity of lipases and esterases from various sources. The long hydrophobic tail of the molecule makes it suitable for use in lipophilic Good solubility in the environment makes it a useful probe for studying lipid metabolism.

HY-W127391

1,2-Dilaurin

(Rac)-1,2-Didodecanoylglycerol

Drug Delivery

1,2-Dilaurin is a diacylglycerol containing lauric acid at the sn-1 and sn-2 positions. It has been used as an internal standard for the quantification of diglycerides in rat desheathed sciatic nerves. [1] Monomolecular films containing 1,2-dilauroyl-rac-glycerol have been used as substrates to measure surface pressure and the effect of pancreatic procolipase and colipase on porcine pancreatic lipase activity. [2] References: [1]. Zhu, X. and Eichberg, J. 1,2-Diacylglycerol content and its arachidonyl-containing molecular species are reduced in the sciatic nerve of streptozotocin-induced diabetic rats. J. Neurochemistry. 55(3), 1087-1090 (1990).[2]. Wieloch, T., Borgstr m, B., Piéroni, G. et al. Porcine trypsinogen and its trypsin-activated form: lipid binding and lipase activation on monomolecular membranes. FEBS Express. 128(2), 217-220 (1981).

HY-D1005

Poloxamer 407 (F127) 2 Publications Verification PEG-PPG-PEG, 12600 (Average Mn)	Co-solvents
Poloxamer 407 (F127) is a nonionic surfactant that is 100% active and relatively non-toxic to cells at low concentrations, and frequently used with dye AM esters such as Indo-1 AM, Fura-2 AM, Calcein AM, Fluo-3 AM, Fluo-4 AM, Quest Fluo-8? AM and Quest Rhod-4? AM, etc. to improve their water solubility. Poloxamer 407 is also a lipoprotein lipase inhibitor .

HY-W014449

4-Nitrophenyl butyrate

Enzyme Substrates

4-Nitrophenyl butyrate consists of butyric acid chains esterified with 4-nitrophenol groups, thus giving it a yellow color. This compound is commonly used as a substrate in enzyme assays to measure esterase and lipase activity. When these enzymes cleave the ester bond, the nitrophenol group is released and the color changes from yellow to orange. Thus, the rate of color change can be used to determine enzyme activity. In addition, 4-Nitrophenyl butyrate can also be used as organic synthesis reagent and dye intermediate.

HY-W283889

Blue caprate	Cell Assay Reagents
Blue caprate is a chromogenic enzyme substrate typically used to detect lipase activity. It is hydrolyzed by lipase to produce a blue-purple product (biosynth: EB04034).

HY-121892

(Z)-KC02

Drug Delivery

(Z)-KC02 is an inhibitor of ABHD16A, the phosphatidylserine (PS) lipase that produces lyso-PS. Lysophosphatidylserine (lyso-PS) is a signaling lipid that regulates immune and neurological processes. It is associated with several neurological disorders such as retinitis pigmentosa and cataracts (PHARC). (Z)-KC02 depletes lyso-PS in lymphoblasts from PHARC subjects. (Z)-KC02 also reduces lyso-PS and lipopolysaccharide-induced cytokine production in macrophages and modulates lyso-PS metabolism in vivo .

Cat. No.	Product Name	Target	Research Area

HY-P3377

Rimtoregtide	Peptides	Inflammation/Immunology
Rimtoregtide is a polypeptide compound which significantly reduces the increase in the levels of amylase and lipase in the blood caused by acute pancreatitis. Rimtoregtide has the potential for the research of pancreatitis and acute pancreatitis (extracted from patent WO2018205233A1).

HY-P1210A

Lys-γ3-MSH(human) TFA	Melanocortin Receptor	Endocrinology
Lys-γ3-MSH(human) TFA is a melanocortin peptide derived from the C-terminal of the fragment of pro-opiomelanocortin (POMC). Lys-γ3-MSH(human) TFA potentiates the steroidogenic response of the rat adrenal to adrenocorticotrophin (ACTH). Lys-γ3-MSH(human) TFA is a potent stimulator of lipolysis with an apparent EC₅₀ of 3.56 nM. Lys-γ3-MSH(human) TFA can activate hormone sensitive lipase (HSL) and Perilipin A resulting in lipolysis .

HY-P1210

Lys-γ3-MSH(human)	Melanocortin Receptor	Endocrinology
Lys-γ3-MSH(human) is a melanocortin peptide derived from the C-terminal of the fragment of pro-opiomelanocortin (POMC). Lys-γ3-MSH(human) potentiates the steroidogenic response of the rat adrenal to adrenocorticotrophin (ACTH). Lys-γ3-MSH(human) is a potent stimulator of lipolysis with an apparent EC₅₀ of 3.56 nM. Lys-γ3-MSH(human) can activate hormone sensitive lipase (HSL) and Perilipin A resulting in lipolysis .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N3797A

Echitamine chloride Ditaine chloride	Apocynaceae Alkaloids Structural Classification Classification of Application Fields Source classification Alstonia scholaris (L.) R. Br. Plants Disease Research Fields Indole Alkaloids Cancer	Apoptosis
Echitamine (Ditaine) chloride is the major monoterpene indole alkaloid present in Alstonia scholaris with potent anti-tumour activity. Echitamine chloride induces DNA fragmentation and cells apoptosis. Echitamine chloride inhibits pancreatic lipase with an IC₅₀ of 10.92 μM .

HY-N12294

Ciwujianoside D2	Triterpenes Structural Classification Polysaccharides Terpenoids Source classification Acanthopanax senticosus (Rupr. et Maxim.) Harms Plants Saccharides Araliaceae	Others
Ciwujianoside D2, a saponin compound, can enhance pancreatic lipase activity in vitro .

HY-N12296

Ciwujianoside C4	Triterpenes Structural Classification Polysaccharides Terpenoids Source classification Acanthopanax senticosus (Rupr. et Maxim.) Harms Plants Saccharides Araliaceae	Others
Ciwujianoside C4, a saponin compound, can enhance pancreatic lipase activity in vitro .

HY-N12297

Ciwujianoside C2	Triterpenes Structural Classification Polysaccharides Terpenoids Source classification Acanthopanax senticosus (Rupr. et Maxim.) Harms Plants Saccharides Araliaceae	Others
Ciwujianoside C2 is a saponin, that can be isolated from the leaves of Acanthopanax senticosus. Ciwujianoside C2 enhances pancreatic lipase activity in vitro .

HY-N12292

Acanthopanaxoside A	Triterpenes Structural Classification Polysaccharides Terpenoids Source classification Acanthopanax senticosus (Rupr. et Maxim.) Harms Plants Saccharides Araliaceae	Others
Acanthopanaxoside A, a triterpenoid saponin, has pancreatic *lipase* inhibitory action .

HY-N8362

1-Isomangostin	Structural Classification Natural Products Source classification Guttiferae Garcinia mangostana Linn. Plants	Others
1-Isomangostin is an inhibitor of pancreatic lipase. 1-Isomangostin inhibits porcine pancreatic lipase with an IC₅₀ of 34.5 μM. 1-Isomangostin has anti-obesity activity .

HY-N12298

Ciwujianoside C1	Triterpenes Structural Classification Polysaccharides Terpenoids Source classification Acanthopanax senticosus (Rupr. et Maxim.) Harms Plants Saccharides Araliaceae	Others
Ciwujianoside C1 is a saponin, that can be isolated from the leaves of Acanthopanax senticosus. Ciwujianoside C1 inhibits pancreatic lipase activity in vitro .

HY-N10606

Uvagrandol	Natural Products Uvaria grandiflora Roxb. Plants Annonaceae	Glucosidase
Uvagrandol potently inhibits α-glucosidase and porcine lipase (IC₅₀: 15.2 μM, 11.2 μM respectively). Uvagrandol can be used in the research of Type 2 diabetes and obesity .

HY-N11999

5,4'-Dihydroxy-3,4,3'-trimethoxybibenzyl	Structural Classification Orchidaceae Source classification Phenols Polyphenols Dendrobium wattii (J. D. Hooker) H. G. Reichenbach Plants	Others
5,4'-Dihydroxy-3,4,3'-trimethoxybibenzyl (compound 8) can be isolated from Dendrobium infundibulum (D. infundibulum). 5,4'-Dihydroxy-3,4,3'-trimethoxybibenzyl has no inhibitory activity against α-glucosidase and pancreatic lipase .

HY-N8989

(1,5E,11E)-Tridecatriene-7,9-diyne-3,4-diacetate	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Plants Compositae Disease Research Fields Erythrina sigmoidea Hua	Others
(1,5E,11E)-Tridecatriene-7,9-diyne-3,4-diacetate, isolated from the ethanol extract of Atractylodes lancea rhizome, displays significant lipase inhibition with an IC₅₀ value of 23.9 µg/mL. Antiobesity Effect .

HY-N13198

4-(4-Hydroxyphenyl)-2-butanone 4'-O-β-D-(2-O-galloyl-6-O-cinnamoyl)glucopyranoside	Structural Classification Rhodiola sacra (Prain ex Raym.-Hamet) S. H. Fu Crassulaceae Source classification Phenols Polyphenols Plants	Endogenous Metabolite
4-(4-Hydroxyphenyl)-2-butanone 4'-O-β-D-(2-O-galloyl-6-O-cinnamoyl)glucopyranoside is a pancreatic lipase inhibitor, with an IC₅₀ value of 2.91 μM. 4-(4-Hydroxyphenyl)-2-butanone 4'-O-β-D-(2-O-galloyl-6-O-cinnamoyl)glucopyranoside can effectively reduce lipid absorption and regulate obesity-related metabolic disorders, making it useful for research on obesity .

HY-P2752

*Lipoprotein lipase, Pseudomonas sp* LPL	Classification of Application Fields Disease Research Fields Cancer	Endogenous Metabolite
Lipoprotein lipase, Pseudomonas sp (LPL) is a multifunctional enzyme from adipose tissue, heart and skeletal muscle, islets and macrophages. Lipoprotein lipase promotes normal lipoprotein metabolism, delivery and utilization of tissue-specific substrates. Lipoprotein lipase catalyzes the rate-limiting step of lipids in blood circulation .

HY-N7668

Neotheaflavin	Flavonoids Classification of Application Fields Flavanols Source classification Phenols Polyphenols Metabolic Disease Plants Camellia sinensis (L.) O. Ktze. Disease Research Fields Theaceae	Others
Neotheaflavin, from black tea, inhibits pancreatic lipase .

HY-N1937

Pristimerin 3 Publications Verification Celastrol methyl ester	Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Celastraceae Tripterygium wilfordii Hook. f. Plants Disease Research Fields Cancer	Bacterial
Pristimerin is a potent and reversible monoacylglycerol lipase (MGL) inhibitor with an IC₅₀ of 93 nM.

HY-N7072

Grape seed extract 1 Publications Verification	Natural Products Classification of Application Fields Source classification Vitis vinifera cv. Zalema Metabolic Disease Plants Vitaceae Disease Research Fields Inflammation/Immunology	Apoptosis
Grape seed extract is a natural product, with anti-inflammatory and anti-proliferative effects. Grape seed extract shows inhibitory activity on the fat-metabolizing enzymes pancreatic lipase and lipoprotein lipase. Grape seed extract induces apoptotic in human colorectal cancer cells .

HY-N2816

Actinidic acid	Triterpenes Structural Classification Ketones, Aldehydes, Acids Terpenoids Source classification Plants Actinidiaceae Actinidia arguta (Sieb. & Zucc) Planch. ex Miq.	Others
Actinidic acid, a coumaroyl triterpene, is a pancreatic lipase inhibitor, with an IC₅₀ of 14.95 μM .

HY-119741

Salacinol	Structural Classification Natural Products Source classification Salacia reticulata Wight Celastraceae Plants	Lipase
Salacinol can be isolated from the roots of the plant Salacia reticulata. Salacinol inhibits fat metabolizing enzymes, such as pancreatic lipase (PL, IC₅₀=12.6 mg/L), lipoprotein lipase (LPL, IC₅₀=13.6 mg/L), and glycerophosphate dehydrogenase (GPDH), enhances the lipolysis, and exhibits antiobesity efficacy in rats .

HY-W004282

Undecanoic acid Undecanoate; Hendecanoic acid	Infection Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Disease Research Fields	Fungal Endogenous Metabolite
Undecanoic acid (Undecanoate) is a monocarboxylic acid with antimycotic property, which inhibits the production of exocellular keratinase, lipase and the biosynthesis of several phospholipids in T. rubrum .

HY-N2087

Ligupurpuroside A	Structural Classification Oleaceae Simple Phenylpropanols Source classification Phenylpropanoids Ligustrum expansum Rehder Plants	Others
Ligupurpuroside A is an active product that can be extracted from Ligustrum robustum. Ligupurpuroside A acts as a natural inhibitor of lipase in a competitive manner .

HY-N1937R

Pristimerin (Standard)	Triterpenes Structural Classification Terpenoids Source classification Celastraceae Tripterygium wilfordii Hook. f. Plants	Bacterial
Pristimerin (Standard) is the analytical standard of Pristimerin. This product is intended for research and analytical applications. Pristimerin is a potent and reversible monoacylglycerol lipase (MGL) inhibitor with an IC₅₀ of 93 nM.

HY-N12893

Sclerodione	Structural Classification Microorganisms Antibiotics Source classification Other Antibiotics	Fungal Lipase
Sclerodione is a metabolite that can be produced by the Scleroderris canker fungus, Gremmeniellaabietina. Sclerodione has antifungal activity. Sclerodione is a *lipase* inhibitor (IC₅₀: 1 μM) .

HY-N0555

Escin IB	Triterpenes Classification of Application Fields Terpenoids Hippocastanaceae Source classification Aesculus hippocastanum Metabolic Disease Plants Disease Research Fields	Others
Escin IB is a saponin isolated from skin and the endosperm of seeds of horse chestnut (Aesculus hippocastanum). Escin IB shows inhibitory effect on pancreatic lipase activity .

HY-N4167

3-O-Methylgalangin Galangin 3-methyl ether; 3-Methylgalangin	Infection Flavonols Flavonoids Classification of Application Fields Source classification Phenols Polyphenols Alpinia officinarum Hance Plants Disease Research Fields Zingiberaceae	Bacterial
3-O-Methylgalangin (Galangin 3-methyl ether) is a natural flavonoid compound from the rhizome of Alpinia officinarum (AO) with antibacterial activities, which also inhibits pancreatic lipase .

HY-N0618

Sanggenon D	Flavanonols Structural Classification Flavonoids Classification of Application Fields Source classification Phenols Polyphenols Plants Moraceae Inflammation/Immunology Disease Research Fields Morus alba Linn.	Others
Sanggenon D is a Diels-Alder-type adduct from Chinese crude agent root bark of mulberry ( Morus alba L.). Sanggenon D possesses antioxidant and inhibits Pancreatic lipase (PL) with the an IC50 of 0.77 μM.

HY-W004282R

Undecanoic acid (Standard) Undecanoate (Standard); Hendecanoic acid (Standard)	Infection Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Disease Research Fields	Fungal Endogenous Metabolite
Undecanoic acid (Standard) is the analytical standard of Undecanoic acid. This product is intended for research and analytical applications. Undecanoic acid (Undecanoate) is a monocarboxylic acid with antimycotic property, which inhibits the production of exocellular keratinase, lipase and the biosynthesis of several phospholipids in T. rubrum .

HY-N0555R

Escin IB (Standard)	Triterpenes Structural Classification Terpenoids Hippocastanaceae Aesculus hippocastanum Source classification Plants	Others
Escin IB (Standard) is the analytical standard of Escin IB. This product is intended for research and analytical applications. Escin IB is a saponin isolated from skin and the endosperm of seeds of horse chestnut (Aesculus hippocastanum). Escin IB shows inhibitory effect on pancreatic lipase activity .

HY-126564

Ebelactone A	Structural Classification Natural Products Microorganisms Source classification	Lipase MetAP
Ebelactone A is a mycolic acid β-lactone, which exhibits inhibitory activity for esterase, *lipase, fMet aminopeptidase (fMet AP) and PNBase, with IC₅₀s of 56, 3, 8 and 7.5 μM, respectively . Ebelactone A inhibits cutinase, exhibits plants protective potency against Erysiphe graminis* .

HY-N0313

Euphol	Triterpenes Structural Classification Classification of Application Fields Terpenoids Euphorbiaceae Plants Inflammation/Immunology Disease Research Fields	MAGL Endogenous Metabolite
Euphol is a tetracyclic triterpene alcohol isolated from the sap of Euphorbia tirucalli with anti-mutagenic, anti-inflammatory and immunomodulatory effects, orally active. Euphol inhibits the *monoacylglycerol lipase* (MGL) activity via a reversible mechanism (IC₅₀**=315 nM). MGL inhibition in the periphery modulates the endocannabinoid system to block the development of inflammatory pain .

HY-N2330

Lipstatin	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification	Others
Lipstatin is a pancreatic lipase inhibitor (IC₅₀=0.14 μM), whose structure is closely related to the known inhibitor, Esterastin. Lipstatin inhibits the absorption of triglycerides without affecting the absorption of oleic acid. Lipstatin has no inhibitory effects on other pancreatic enzymes, such as phospholipase A2 and trypsin (<200 μM) .

HY-N4298

Epitheaflagallin 3-O-gallate	Classification of Application Fields Source classification Phenols Polyphenols Plants Camellia sinensis (L.) O. Ktze. Disease Research Fields Inflammation/Immunology Theaceae	MMP
Epitheaflagallin 3-O-gallate is a minor polyphenol in black tea. Epitheaflagallin 3-O-gallate exhibits versatile physiological functions in vivo and in vitro, including antioxidative activity, pancreatic lipase inhibition, Streptococcus sorbinusglycosyltransferase inhibition, and an inhibiting effect on the activity of matrix metalloprotease-1 and -3 and their synthesis by human gingival fibroblasts .

Cat. No.	Product Name	Chemical Structure

HY-W004282S

Undecanoic acid-d21
Undecanoic acid-d₂₁ is the deuterium labeled Undecanoic acid. Undecanoic acid (Undecanoate) is a monocarboxylic acid with antimycotic property, which inhibits the production of exocellular keratinase, lipase and the biosynthesis of several phospholipids in T. rubrum[1].

HY-W004282S1

Undecanoic acid-d3
Undecanoic acid-d₃ is the deuterium labeled Undecanoic acid. Undecanoic acid (Undecanoate) is a monocarboxylic acid with antimycotic property, which inhibits the production of exocellular keratinase, lipase and the biosynthesis of several phospholipids in T. rubrum[1].

HY-W004282S2

Undecanoic acid-d2
Undecanoic acid-d₂ is the deuterium labeled Undecanoic acid. Undecanoic acid (Undecanoate) is a monocarboxylic acid with antimycotic property, which inhibits the production of exocellular keratinase, lipase and the biosynthesis of several phospholipids in T. rubrum[1].

HY-B0218S

Orlistat-d3
Orlistat-d3 is a deuterated labeled Orlistat . Orlistat (Tetrahydrolipstatin) is a well-known irreversible inhibitor of pancreatic and gastric *lipases. Orlistat is also an inhibitor of fatty acid synthase (FASN*), is used orally for long-term research of obesity .?Anti-atherosclerotic?effect .

Cat. No.	Product Name		Classification

HY-120171

DH-376		Alkynes
DH-376 is a potent diacylglycerol lipase inhibitor with pIC₅₀ values of 8.6 and 8.9 for ABHD6 and DAGLα, respectively. DH-376 prevents fasting-induced refeeding of mice . DH-376 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Cat. No.	Product Name		Classification