Search Result

Results for "

substrate specificity

" in MedChemExpress (MCE) Product Catalog:

By Targets:	AMPK (1) Amylases (1) Angiotensin-converting Enzyme (ACE) (5) Apoptosis (1) ASCT (1) Autophagy (1) Biochemical Assay Reagents (16) Btk (1) Calcium Channel (1) CaMK (2) Caspase (1) Cathepsin (2) Cytochrome P450 (2) DNA/RNA Synthesis (3) Dopamine Receptor (1) Elastase (1) Endogenous Metabolite (5) Factor Xa (2) FAP (1) Fluorescent Dye (29) HDAC (1) Histone Acetyltransferase (1) Histone Methyltransferase (2) HIV Protease (1) HSV (1) Macrophage migration inhibitory factor (MIF) (1) Mitochondrial Metabolism (2) MMP (29) Nucleoside Antimetabolite/Analog (1) Oxidative Phosphorylation (1) PDK-1 (1) Phosphatase (2) Phosphodiesterase (PDE) (6) PKA (4) PKC (4) PROTACs (1) Protease Activated Receptor (PAR) (1) Proteasome (3) PSMA (1) Ser/Thr Protease (1) Src (3) Thrombin (1)
By Research Areas:	Cancer (29) Cardiovascular Disease (6) Endocrinology (1) Infection (7) Inflammation/Immunology (46) Metabolic Disease (14) Neurological Disease (5)
Oligonucleotides:	Nucleosides and their Analogs (1)

152

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Natural
Products

Oligonucleotides

Ac-Nle-Pro-Nle-Asp-AMC	Proteasome	Others
Ac-Nle-Pro-Nle-Asp-AMC is a specific substrate for 26S proteasome. Ac-Nle-Pro-Nle-Asp-AMC can be used for the 26S proteasome caspase-like activity analysis .

*Fluorescent Substrate* for Glu-Specific Proteases**	Fluorescent Dye	Others
Fluorescent Substrate for Glu-Specific Proteases is a V8 protease-Specific chromogenic substrate .

MOCPAC	HDAC	Cancer
MOCPAC is an HDAC1 specific substrate .

4-Nitrophenyl N-acetyl-α-D-glucosaminide	Biochemical Assay Reagents	Others
4-Nitrophenyl N-acetyl-α-D-glucosaminide is a 4-nitrophenyl- conjugated substrate for determining the enzymatic specificity .

p-APMSF hydrochloride p-Amidinophenylmethylsulfonylfluoride hydrochloride	Others	Others
p-APMSF is an irreversible inhibitor of serinase. p-APMSF has substrate specificity for positively charged side chains of amino acids, lysine, or arginine. p-APMSF can be used to study the irreversible inhibition of trypsin and thrombin .

Benzoyl coenzyme A Benzoyl CoA	Endogenous Metabolite	Others Metabolic Disease
Benzoyl coenzyme A (Benzoyl CoA) is A derivative of Coenzyme A (CoA) in which the mercaptan group of CoA binds to the benzoyl group. Benzoyl coenzyme A is involved in the catalytic reaction as a substrate for the acyl transfer reaction. Benzoyl coenzyme A is a versatile metabolic intermediate that can be used to reveal substrate specificity of enzymes, metabolic regulation, and drug metabolism .

ssK36	Histone Methyltransferase	Cancer
ssK36 is a supersubstrate peptide of the histone methyltransferase (SET) domain protein 2 (SETD2), and ssK36 is designed for the SETD2 protein, a specific PKMT. It is responsible in human cells for adding methyl groups to the 36th lysine residue of histone H3 (H3K36) to form H3K36me3. ssK36 can be methylated by SETD2 at a rate more than 100 times faster than the natural substrate H3K36. ssK36 can be used to study the catalytic mechanism of PKMTs, especially substrate specificity and catalytic efficiency .

Prostate Specific Antigen Substrate	PSMA	Cancer
Prostate Specific Antigen Substrate is a prostate specific antigen (PSA) fluorescent substrate. Prostate Specific Antigen Substrate can be used for detect enzymatic activity of PSA .

*Fluorescent Substrate* for Pro-Specific Proteases**	Fluorescent Dye	Others
Fluorescent Substrate for Pro-Specific Proteases is a fluorescent substrate of pro-specific proteases. Fluorescent Substrate for Pro-Specific Proteases can be used to detect the hydrolysis rate and activity of target enzyme .

*Fluorescent Substrate* for Asp-Specific Proteases**	Fluorescent Dye	Others
Fluorescent Substrate for Asp-Specific Proteases is a substrate to cleave specifically the Asp-Val bond .

IDT307	Fluorescent Dye	Others
IDT307, an analog of the organic cation MPP+, is a specific fluorescent substrate for DAT (fluorescent substrate APP+) .

Linoleoyl-CoA	Endogenous Metabolite	Others
Linoleoyl-CoA is a substrate used to study the specificity and kinetics of acyl-CoA. Linoleoyl-CoA has the ability to replace substrates, and its specificity can be changed by amino acid substitution, thereby affecting the reaction with different desaturases. The study of linoleoyl-CoA helps to understand the substrate specificity of mammalian front-end fatty acid desaturases and provides support for the efficient production of value-added fatty acids .

Bz-Lys-OMe	Biochemical Assay Reagents	Others
Bz-Lys-Ome is a specific methyl ester substrate of trypsin .

Ac-Phe-Gly-pNA	Ser/Thr Protease	Others
Ac-Phe-Gly-pNA is the chymotrypsin specific substrate .

SAMS 2 Publications Verification	AMPK	Metabolic Disease
SAMS peptide is a specific substrate for the AMP-activated protein kinase (AMPK).

RR-SRC	Src	Inflammation/Immunology
RR-SRC is a substrate for *src-tyrosine-specific* protein kinase** .

Protein kinase C substrate	PKC	Others
Protein kinase C substrate is a substrate of Protein kinase C, can be used to detect protein. Protein kinase C is a key regulatory element in signal transduction and exerts its effects by catalysing specific substrate phosphorylation .

Lys-Pro-AMC	Fluorescent Dye	Others
Lys-Pro-AMC is a fluorogenic substrate for the detection and measurement of the activity of specific enzymes .

Kemptide	PKA	Metabolic Disease
Kemptide is a synthetic heptapeptide that acts as a specific substrate for cAMP-dependent protein kinase (PKA).

Lys-Pro-AMC diTFA	Fluorescent Dye	Others
Lys-Pro-AMC diTFA is a fluorogenic substrate for the detection and measurement of the activity of specific enzymes .

EWFW-ACC TFA	Biochemical Assay Reagents	Others
EWFW-ACC TFA is a specific immunoproteasome substrate that can be used to study immunoproteasome function .

Resorufin methyl ether Methoxyresorufin	Cytochrome P450	Others
Resorufin methyl ether (Methoxyresorufin) is a cytochrome P450 fluorometric substrate . Resorufin methyl ether is a relatively specific substrate for CYP1A2 activity in rodents .

CSK substrate	Src	Others
CSK substrate is a specific substrate for C-terminal Src kinase (CSK), which binds CSK and downregulates the Src family members. CSK substrate preferentially phosphorylates certain amino acid residues that are distinct from the conserved Src C-terminal sequence .

H-Ala-4MβNA hydrochloride	Fluorescent Dye	Others
H-Ala-4MβNA hydrochloride is a specific fluorogenic substrate for aminopeptidase M .

Suc-Ile-Glu(γ-pip)-Gly-Arg-pNA hydrochloride	Factor Xa	Others
Suc-Ile-Glu(γ-pip)-Gly-Arg-pNA hydrochloride is a factor Xa specific chromogenic substrate .

Ac-WLA-AMC	Proteasome	Inflammation/Immunology
Ac-WLA-AMC is a specific 20S constitutive proteasome β5 fluorogenic substrate .

p60c-src Substrate	Src Others	Others
p60c-src Substrate is an efficient and specific substrate for p60c-src protein tyrosine kinase (PTK). p60c-src Substrate can be used to synthesize chimeric branched peptides .

Kemptide Phospho-Ser5	PKA	Others
Kemptide (Phospho-Ser5) is a phosphate acceptor peptide that serves as a specific substrate for cAMP-dependent protein kinase (PKA).

PL553	Fluorescent Dye	Inflammation/Immunology
PL553 is a specific and high-affinity fluorigenic substrate of Leukotriene A4 hydrolase, with a λ_max of 210 nm and λ_em of 410 nm.

Z-IETD-AFC	Fluorescent Dye	Cancer
Z-IETD-AFC, a specific fluorescence substrate, can be used to determine the caspase-8 catalytic activity .

PKCδ Peptide Substrate	PKC	Others
PKCδ Peptide Substrate is an absolutely specific substrate for the δ-type of PKC, with a sequence corresponding to sequence 422-443 of murine eEF-1α and containing Thr-431 .

Calpain-1 substrate, fluorogenic	Fluorescent Dye	Others
Calpain-1 substrate, fluorogenic serves as a sensitive and specific substrate for calpain-1 that cleaves Tyr-Gly bond and results in enhanced fluorescence .(Ex/Em = 490 nm/518 nm)

N-Butylfluorescein	Fluorescent Dye	Others
N-Butylfluorescein is an alkyl-substituted fluorescein, can be used for synthesis of fluorogenic substrates for assaying phosphatidylinositol-specific phospholipase C .

Z-Gly-Gly-Arg-AMC 5+ Cited Publications	Fluorescent Dye	Cardiovascular Disease
Z-Gly-Gly-Arg-AMC is a thrombin-specific fluorogenic substrate for testing of thrombin generation in PRP and platelet-poor plasma (PPP).

Z-Gly-Gly-Arg-AMC acetate 5+ Cited Publications	Fluorescent Dye	Others
Z-Gly-Gly-Arg-AMC acetate is a thrombin-specific fluorogenic substrate for testing of thrombin generation in PRP and platelet-poor plasma (PPP).

N-Acetyl-Ser-Asp-Lys-Pro Ac-SDKP	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease Inflammation/Immunology
N-Acetyl-Ser-Asp-Lys-Pro, an endogenous tetrapeptide secreted by bone marrow, is a specific substrate for the N-terminal site of ACE.

Fluorescein Di-β-D-Glucopyranoside	Fluorescent Dye	Cancer
Fluorescein Di-β-D-Glucopyranoside is a specific β-glucocerebrosidase substrate that can be used for the intralysosomal β-galactosidase .

Isocaproaldehyde 4-Methylpentanal; 4-Methylvaleraldehyde	Others	Metabolic Disease
Isocaproaldehyde is a product of side-chain cleavage of cholesterol. Isocaproaldehyde is an endogenous specific substrate of mouse vas deferens protein (MVDP) .

D-Ala-Lys-AMCA	Fluorescent Dye	Cancer
D-Ala-Lys-AMCA is a known proton-coupled oligopeptide transporter 1 (PEPT1) substrate that emits blue fluorescence. D-Ala-Lys-AMCA may be transported into liver cancer cells and Caco-2 cells based on fluorescence analysis. D-Ala-Lys-AMCA can be used for characterizing PEPT1-specific substrates or inhibitors .

D-Ala-Lys-AMCA hydrochloride 1 Publications Verification	Fluorescent Dye	Cancer
D-Ala-Lys-AMCA hydrochloride is a known proton-coupled oligopeptide transporter 1 (PEPT1) substrate that emits blue fluorescence. D-Ala-Lys-AMCA hydrochloride may be transported into liver cancer cells and Caco-2 cells based on fluorescence analysis. D-Ala-Lys-AMCA hydrochloride can be used for characterizing PEPT1-specific substrates or inhibitors .

Bovine Factor IXa Beta	Others	Others
Bovine Factor IXa Beta is an inactive and highly specific enzyme, with a minimal extended substrate recognition site and a preference for particular amino acid residues at specific subsites. Bovine Factor IXa Beta plays a role in the blood coagulation cascade .

HSV-1 Protease substrate	HSV	Infection
HSV-1 Protease substrate is a peptide substrate for HSV-1 (Herpes Simplex Virus Type 1) protease, and the specificity constant (k_cat/K_m) at pH 7.5 for cleavage is 5.2 M ^-1 s ^-1 .

N-Acetyl-Ser-Asp-Lys-Pro TFA Ac-SDKP TFA	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease Inflammation/Immunology
N-Acetyl-Ser-Asp-Lys-Pro (TFA), an endogenous tetrapeptide secreted by bone marrow, is a specific substrate for the N-terminal site of ACE.

D-Ala-Lys-AMCA TFA	Fluorescent Dye	Cancer
D-Ala-Lys-AMCA TFA is a known proton-coupled oligopeptide transporter 1 (PEPT1) substrate that emits blue fluorescence. D-Ala-Lys-AMCA TFA may be transported into liver cancer cells and Caco-2 cells based on fluorescence analysis. D-Ala-Lys-AMCA TFA can be used for characterizing PEPT1-specific substrates or inhibitors .

YD1342	Histone Methyltransferase	Cancer
YD1342 is a prodrug of YD1130, which exhibits potent inhibitory effects on cellular substrate methylation, breast cancer cell clonogenicity, and tumor growth in animal models, exceeding or matching known PRMT4-specific inhibitors. .

Suc-Gly-Pro-AMC	FAP	Cancer
Suc-Gly-Pro-AMC is a fibroblast activation protein (FAP)-specific substrate. Suc-Gly-Pro-AMC can be used to study the activity of FAP .

Cat. No.	Product Name

HY-L081

Phosphatase Inhibitor Library

117 compounds

Protein phosphorylation is a key post-translational modification underlying the regulation of many cellular processes. Phosphatases and kinases contribute to the regulation of protein phosphorylation homeostasis in the cell. This reversible regulation of protein phosphorylation is critical for the proper control of a wide range of cellular activities, including cell cycle, proliferation and differentiation, metabolism, cell-cell interactions, etc.

Protein phosphatases have evolved in separate families that are structurally and mechanistically distinct. Based on substrate specificity and functional diversity, protein phosphatases are classified into two superfamilies: Protein serine/threonine phosphatases and Protein tyrosine phosphatases. Ser/Thr phosphatases are metalloenzymes belonging to two major gene families termed PPP (phosphoprotein phosphatase) and PPM (metal-dependent protein phosphatases), whereas protein tyrosine phosphatases (PTPs) belong to distinct classes of enzymes that utilize a phospho-cysteine enzyme intermediate as a part of their catalytic action.

MCE supplies a unique collection of 117 phosphatase inhibitors that mainly targeting protein tyrosine phosphatases (PTPs) and serine/threonine-specific protein phosphatases. MCE Phosphatase Inhibitor Library is a useful tool for phosphatase drug discovery and related research.

HY-L906

Norepinephrine Transporter (NET) Compound Library

650 compounds

On May 15, 2024, "Dimerization and antidepressant recognition at noradrenaline transporter" was published online by Nature. The research findings were an effort from Shanghai Institute of Materia Medica, Chinese Academy of Sciences. This study unraveled the important neural system target - the noradrenaline transporter (NET), obtaining the binding modes of human NET homodimers with the natural substrate norepinephrine (NE) and six selective antidepressants. It laid an important theoretical foundation for understanding the physiological regulation mechanisms of NET and other monoamine transporters.

The Norepinephrine Transporter (NET) Compound Library is obtained by computer-aided virtual screening based on the HY-L901 compound library . The specific screening process includes molecular docking screening, key pharmacophore screening, and CNS-MPO screening, which can be used for new drug discovery targeting the noradrenaline transporter.

Cat. No.	Product Name	Type

HY-129096

IDT307	Chromogenic Substrates
IDT307, an analog of the organic cation MPP+, is a specific fluorescent substrate for DAT (fluorescent substrate APP+) .

HY-D0144

Resorufin methyl ether Methoxyresorufin	Chromogenic Substrates
Resorufin methyl ether (Methoxyresorufin) is a cytochrome P450 fluorometric substrate . Resorufin methyl ether is a relatively specific substrate for CYP1A2 activity in rodents .

HY-123051

Ac-WLA-AMC	Fluorescent Dyes/Probes
Ac-WLA-AMC is a specific 20S constitutive proteasome β5 fluorogenic substrate .

HY-P2208

Z-IETD-AFC	Fluorescent Dyes/Probes
Z-IETD-AFC, a specific fluorescence substrate, can be used to determine the caspase-8 catalytic activity .

HY-P0019

Z-Gly-Gly-Arg-AMC Maximum Cited Publications 9 Publications Verification	Chromogenic Substrates
Z-Gly-Gly-Arg-AMC is a thrombin-specific fluorogenic substrate for testing of thrombin generation in PRP and platelet-poor plasma (PPP).

HY-P0019A

Z-Gly-Gly-Arg-AMC acetate Maximum Cited Publications 9 Publications Verification	Chromogenic Substrates
Z-Gly-Gly-Arg-AMC acetate is a thrombin-specific fluorogenic substrate for testing of thrombin generation in PRP and platelet-poor plasma (PPP).

HY-137928

H-Ala-4MβNA hydrochloride	Fluorescent Dyes/Probes
H-Ala-4MβNA hydrochloride is a specific fluorogenic substrate for aminopeptidase M .

HY-U00452

PL553	Fluorescent Dyes/Probes
PL553 is a specific and high-affinity fluorigenic substrate of Leukotriene A4 hydrolase, with a λ_max of 210 nm and λ_em of 410 nm.

HY-D1461

Fluorescein Di-β-D-Glucopyranoside	Fluorescent Dyes/Probes
Fluorescein Di-β-D-Glucopyranoside is a specific β-glucocerebrosidase substrate that can be used for the intralysosomal β-galactosidase .

HY-111956

D-Ala-Lys-AMCA	Fluorescent Dyes/Probes
D-Ala-Lys-AMCA is a known proton-coupled oligopeptide transporter 1 (PEPT1) substrate that emits blue fluorescence. D-Ala-Lys-AMCA may be transported into liver cancer cells and Caco-2 cells based on fluorescence analysis. D-Ala-Lys-AMCA can be used for characterizing PEPT1-specific substrates or inhibitors .

HY-111956B

D-Ala-Lys-AMCA hydrochloride 1 Publications Verification	Fluorescent Dyes/Probes
D-Ala-Lys-AMCA hydrochloride is a known proton-coupled oligopeptide transporter 1 (PEPT1) substrate that emits blue fluorescence. D-Ala-Lys-AMCA hydrochloride may be transported into liver cancer cells and Caco-2 cells based on fluorescence analysis. D-Ala-Lys-AMCA hydrochloride can be used for characterizing PEPT1-specific substrates or inhibitors .

HY-111956A

D-Ala-Lys-AMCA TFA	Fluorescent Dyes/Probes
D-Ala-Lys-AMCA TFA is a known proton-coupled oligopeptide transporter 1 (PEPT1) substrate that emits blue fluorescence. D-Ala-Lys-AMCA TFA may be transported into liver cancer cells and Caco-2 cells based on fluorescence analysis. D-Ala-Lys-AMCA TFA can be used for characterizing PEPT1-specific substrates or inhibitors .

HY-137834

Gly-Pro-AMC hydrobromide 1 Publications Verification	Fluorescent Dyes/Probes
Gly-Pro-AMC hydrobromide is a fluorescent dye, it can be used as a specific fluorescent substrate for detecting Dipeptidyl peptidase IV (DPP-IV) activity .

HY-P2536

Mca-Ala-Pro-Lys(Dnp)-OH	Fluorescent Dyes/Probes
Mca-Ala-Pro-Lys(Dnp)-OH, a specific ACE2 quenched fluorogenic substrate, can be used to detect ACE2 activity, such as urinary, heart and lung .

HY-P0136AF

FAM-SAMS TFA	Dyes
FAM-SAMS TFA is a 5-FAM (HY-66022) labeled SAMS (HY-P0136). SAMS peptide is a specific substrate for the AMP-activated protein kinase (AMPK) .

HY-D1523

Z-Arg-Arg-4MβNA triacetate	Fluorescent Dyes/Probes
Z-Arg-Arg-4MβNA triacetate is a cathepsin B-specific substrate and can produce fluorescent end product 4MβNA (λ_ex = 355 nm, λ_em = 430 nm) .

HY-D1676

Thymolphthalein monophosphate disodium hydrate

Fluorescent Dyes/Probes

Thymolphthalein monophosphate disodium hydrate is a chromogenic substrate for the determination of acid phosphatase and alkaline phosphatase. Thymolphthalein is released during the reaction, increases the pH of the medium for easy detection, produces color and stops hydrolysis. Thymolphthalein monophosphate disodium hydrate can be used for the specific detection of prostatic phosphatase in serum .

HY-118155

9-Amino-6-chloro-2-methoxyacridine	Fluorescent Dyes/Probes
9-Amino-6-chloro-2-methoxyacridine is a pH sensitive fluorescent probe. 9-Amino-6-chloro-2-methoxyacridine has been frequently used to measure changes in vacuolar pH when a specific substrate crosses the tonoplast through a putative H ⁺/solute antiport system .

HY-116862

Dibenzylfluorescein

DBF

Fluorescent Dyes/Probes

Dibenzylfluorescein (DBF) is a fluorogenic probe (Fluoresecent dye) that acts as a substrate for specific cytochrome P450 (CYP) isoforms, including CYP3A4, CYP2C8, CYP2C9, CYP2C19, and aromatase (CYP19). Dibenzylfluorescein is typically used near its K_m value of 0.87-1.9 µM (Ex=485nm，Em=535nm). Dibenzylfluorescein is used to detect changes in CYP catalytic activity caused by drugs or disease .

Cat. No.	Product Name	Type

HY-D0861

EGTA 10+ Cited Publications	Chelators
EGTA is a specific calcium ion chelator. EGTA has an apparent calcium dissociation constant (K_d) of 60.5 nM at physiological pH (7.4) and has very high specificity for Ca ²⁺ over Mg ²⁺ (Mg ²⁺ K_d 1-10 mM). EGTA significantly inhibits the substrate adherence capacity of inflammatory macrophages .

HY-137841

L-Arginine-7-amido-4-methylcoumarin hydrochloride Arginine 4-methyl-7-coumarylamide hydrochloride	Enzyme Substrates
L-Arginine-7-amido-4-methylcoumarin (Arginine 4-methyl-7-coumarylamide) hydrochloride is a specific substrate of cathepsin H but not for cathepsins L and B .

HY-134425

β-Methylcrotonyl coenzyme A lithium	Enzyme Substrates
β-Methylcrotonyl coenzyme A lithium is an intermediate in leucine metabolism and can be used as a substrate to study the specificity and kinetics of β-methylcrotonyl coenzyme A carboxylase (MCCase) .

HY-W718137

6-Azido-6-deoxy-D-galactose，95%	Carbohydrates
6-Azido-6-deoxy-D-galactose, 95% can be used as a substrate in enzymology to study the activity and specificity of galactosyltransferases and other glycosylation enzymes.

HY-W250153

Adenosine 3'-phosphate 5'-phosphosulfate lithium	Biochemical Assay Reagents
Adenosine 3'-phosphate 5'-phosphosulfate lithium is a co-substrate used for the sulfonation of glycans. Adenosine 3'-phosphate 5'-phosphosulfate lithium can be used for Golgi-resident PAP-specific 3'-phosphatase-coupled sulfotransferase assays, which as donor substrate to transfer a sulfonate group .

HY-W250153A

Adenosine 3'-phosphate 5'-phosphosulfate lithium, hydrate	Biochemical Assay Reagents
Adenosine 3'-phosphate 5'-phosphosulfate lithium is a co-substrate used for the sulfonation of glycans. Adenosine 3'-phosphate 5'-phosphosulfate lithium can be used for Golgi-resident PAP-specific 3'-phosphatase-coupled sulfotransferase assays, which as donor substrate to transfer a sulfonate group .

HY-D0861A

EGTA tetrasodium	Biochemical Assay Reagents
EGTA tetrasodium is a specific calcium ion chelator. EGTA tetrasodium has an apparent calcium dissociation constant (K_d) of 60.5 nM at physiological pH (7.4) and has very high specificity for Ca ²⁺ over Mg ²⁺ (Mg ²⁺ K_d 1-10 mM). EGTA tetrasodium significantly inhibits the substrate adherence capacity of inflammatory macrophages .

HY-E70191

β-1,4-Galactosyltransferase 2 EC:2.4.1.22; B4GALT2	Enzyme Substrates
β-1,4-Galactosyltransferase 2 catal exclusive specificity for the donor substrate UDP-galactose and all transfer galactosein a beta1,4 linkage .

HY-W002291

p-Fluoro-L-phenylalanine 4-Fluoro-L-phenylalanine	Biochemical Assay Reagents
p-Fluoro-L-phenylalanine (4-Fluoro-L-phenylalanine) is a substrate for tyrosine hydroxylase (TH) that can be used to study the regulation of that enzyme. p-Fluoro-L-phenylalanine binds to the L-leucine specific receptor of Escherichia coli (K_D=0.26 μM) .

HY-E70138

β-1,4-Galactosyltransferase 7 EC:2.4.1.133; B4GALT7	Enzyme Substrates
β-1,4-Galactosyltransferase 7 has exclusive specificity for the donor substrate UDP-galactose and all transfer galactose in a β-1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. .

HY-NP122

Highly purified Type I collagen, from porcine skin Porcine Type I collagen, immunization grade	Native Proteins
Highly purified Type I collagen, from porcine skin (Porcine Type I collagen, immunization grade) is an immune grade collagen derived from porcine skin, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .

HY-NP127

Highly purified Type I collagen, from canine skin Canine Type I collagen, immunization grade	Native Proteins
Highly purified Type I collagen, from canine skin (Canine Type I collagen, immunization grade) is an immune grade collagen derived from canine skin, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .

HY-NP107

Highly purified Type I collagen, from rat skin Rat Type I collagen, immunization grade	Native Proteins
Highly purified Type I collagen, from rat skin (Rat Type I collagen, immunization grade) is an immune grade collagen derived from rat skin, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .

HY-NP109

Highly purified type I collagen, from mouse skin Mouse Type I collagen, immunization grade	Native Proteins
Highly purified type I collagen, from mouse skin (Mouse Type I collagen, immunization grade) is an immune grade collagen derived from mouse skin, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .

HY-NP111

Highly purified Type V collagen, from mouse intestine Mouse Type V collagen, immunization grade	Native Proteins
Highly purified Type V collagen, from mouse intestine (Mouse Type II collagen, immunization grade) is an immune grade collagen derived from mouse intestine, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .

HY-NP112

Highly purified Type I collagen, from chick skin Chick type I collagen, immunization grade	Native Proteins
Highly purified Type I collagen, from chick skin (Chick type I collagen, immunization grade) is an immune grade collagen derived from chick skin, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .

HY-NP118

Highly purified Type III collagen, from human placenta Human Type III collagen, immunization grade	Native Proteins
Highly purified Type III collagen, from human placenta (Human Type III collagen, immunization grade) is an immune grade collagen derived from human placenta, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .

HY-NP124

Highly purified Type III collagen, from porcine skin Porcine Type III collagen, immunization grade	Native Proteins
Highly purified Type III collagen, from porcine skin (Porcine Type III collagen, immunization grade) is an immune grade collagen derived from porcine skin, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .

HY-NP128

Highly purified Type I collagen, from rabbit skin Rabbit Type I collagen, immunization grade	Native Proteins
Highly purified Type I collagen, from rabbit skin (Canine Type I collagen, immunization grade) is an immune grade collagen derived from rabbit skin, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .

HY-NP116

Highly purified Type I collagen, from human placenta Human Type I collagen, immunization grade	Native Proteins
Highly purified Type I collagen, from human placenta (Human Type I collagen, immunization grade) is an immune grade collagen derived from human placenta, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .

HY-NP103

Highly purified Type III collagen, from bovine skin Bovine Type III collagen, immunization grade	Native Proteins
Highly purified Type III collagen, from bovine skin (Bovine Type III collagen, immunization grade) is an immune grade collagen derived from bovine skin, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .

HY-NP123

Highly purified Type II collagen, from porcine articular cartilage Porcine Type II collagen, immunization grade	Native Proteins
Highly purified Type II collagen, from porcine articular cartilage (Porcine Type II collagen, immunization grade) is an immune grade collagen derived from porcine articular cartilage, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .

HY-NP126

Highly purified Type XI collagen, from porcine articular cartilage Porcine Type XI collagen, immunization grade	Native Proteins
Highly purified Type XI collagen, from porcine articular cartilage (Porcine Type XI collagen, immunization grade) is an immune grade collagen derived from porcine articular cartilage, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .

HY-NP120

Highly purified Type V collagen, from human placenta Human Placenta Type V collagen, immunization grade	Native Proteins
Highly purified Type V collagen, from human placenta (Human Placenta Type V collagen, immunization grade) is an immune grade collagen derived from human placenta, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .

HY-NP113

Highly purified Type II collagen, from chick sternal cartilage Chick Type II collagen, immunization grade	Native Proteins
Highly purified Type II collagen, from chick sternal cartilage (Chick Type II collagen, immunization grade) is an immune grade collagen derived from chick sternal cartilage, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .

HY-NP105

Highly purified Type IX collagen, from bovine articular cartilage Bovine Type IX collagen, immunization grade	Native Proteins
Highly purified Type IX collagen, from bovine articular cartilage (Bovine Type IX collagen, immunization grade) is an immune grade collagen derived from bovine articular cartilage, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .

HY-NP108

Highly purified type II collagen, from rat sternal cartilage Rat Type II collagen, immunization grade	Native Proteins
Highly purified type II collagen, from rat sternal cartilage (Rat Type II collagen, immunization grade) is an immune grade collagen derived from rat sternal cartilage, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .

HY-NP110

Highly purified Type II collagen, from mouse sternal cartilage Mouse Type II collagen, immunization grade	Native Proteins
Highly purified Type II collagen, from mouse sternal cartilage (Mouse Type II collagen, immunization grade) is an immune grade collagen derived from mouse sternal cartilage, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .

HY-NP114

Highly purified Type IX collagen, from chick articular cartilage Chick Type IX collagen, immunization grade	Native Proteins
Highly purified Type IX collagen, from chick articular cartilage (Chick Type IX collagen, immunization grade) is an immune grade collagen derived from chick articular cartilage, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .

HY-NP121

Highly purified Type XI collagen, from human sternal cartilage Human Type XI collagen, immunization grade	Native Proteins
Highly purified Type XI collagen, from human sternal cartilage (Human Type XI collagen, immunization grade) is an immune grade collagen derived from human sternal cartilage, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .

HY-NP119

Highly purified Type V collagen, from human amnion Human Amnion Type V collagen, immunization grade	Native Proteins
Highly purified Type V collagen, from human amnion (Human Amnion Type V collagen, immunization grade) is an immune grade collagen derived from human amnion, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .

HY-NP125

Highly purified Type IX collagen, from porcine articular cartilage Porcine Type IX collagen, immunization grade	Native Proteins
Highly purified Type IX collagen, from porcine articular cartilage (Porcine Type IX collagen, immunization grade) is an immune grade collagen derived from porcine articular cartilage, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .

HY-NP129

Highly purified Type II collagen, from sheep articular cartilage Sheep Type II collagen, immunization grade	Native Proteins
Highly purified Type II collagen, from sheep articular cartilage (Sheep Type II collagen, immunization grade) is an immune grade collagen derived from sheep articular cartilage, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .

HY-NP130

Highly purified Type II collagen, from goat articular cartilage Goat Type II collagen, immunization grade	Native Proteins
Highly purified Type II collagen, from goat articular cartilage (Goat Type II collagen, immunization grade) is an immune grade collagen derived from goat articular cartilage, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .

HY-NP117

Highly purified Type II collagen, from human sternal cartilage Human Type II collagen, immunization grade	Native Proteins
Highly purified Type II collagen, from human sternal cartilage (Human Type II collagen, immunization grade) is an immune grade collagen derived from human sternal cartilage, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .

HY-NP104

Highly purified Type V collagen, from bovine amnion Bovine Amnion Type V collagen, immunization grade	Native Proteins
Highly purified Type V collagen, from bovine amnion (Bovine Amnion Type V collagen, immunization grade) is an immune grade collagen derived from bovine amnion, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .

HY-NP106

Highly purified Type XI collagen, from bovine articular cartilage Bovine Type XI collagen, immunization grade	Native Proteins
Highly purified Type XI collagen, from bovine articular cartilage (Bovine Type XI collagen, immunization grade) is an immune grade collagen derived from bovine articular cartilage, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .

HY-NP115

Highly purified Type XI collagen, from chick articular cartilage Chick Type XI collagen, immunization grade	Native Proteins
Highly purified Type XI collagen, from chick articular cartilage (Chick Type XI collagen, immunization grade) is an immune grade collagen derived from chick articular cartilage, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .

HY-W583212

Zn(II) Mesoporphyrin IX

ZnMP

Cell Assay Reagents

Zn(II) Mesoporphyrin IX (ZnMP) is a specific activator of ABCB10, significantly increasing its ATPase activity and acting as a substrate for ABCB10 in heme synthesis. Zn(II) Mesoporphyrin IX may promote the transcription of hemoglobinization genes by facilitating the degradation of the Bach1 repressor. Zn(II) Mesoporphyrin IX aids in studying the potential roles of ABCB10 in heme synthesis, oxidative stress protection, hepatitis C, and other areas .

HY-W127380

Arachidonoyl thio-PC

Enzyme Substrates

Arachidonoyl Thio-PC is a substrate of many phospholipase A2 (PLA2), including sPLA2, cPLA2 and iPLA2. Cleavage of sn-2 fatty acids by PLA2 results in the production of free thiols, which react with chromogenic reagents such as DTNB (Ellman's reagent) and DTP, allowing quantification of PLA2 activity. Isozyme-specific cPLA2 activity can be measured by depleting or inhibiting sPLA2 and iPLA2 activity in the assay.

HY-W777640

6-Hexadecanoylamino-4-methylumbelliferyl β-D-galactopyranoside

Enzyme Substrates

6-Hexadecanoylamino-4-methylumbelliferyl β-D-galactopyranoside is a specific fluorescent substrate with the function of detecting galactosidase activity. 6-Hexadecanoylamino-4-methylumbelliferyl β-D-galactopyranoside can be used in biomedical research to observe the efficiency of enzyme-catalyzed reactions. 6-Hexadecanoylamino-4-methylumbelliferyl β-D-galactopyranoside is also widely used in the analysis of polysaccharides and carbohydrate enzymology.

HY-137779

5-Bromo-4-chloro-3-indolyl β-D-glucopyranoside

Carbohydrates

5-Bromo-4-chloro-3-indolyl β-D-glucopyranoside, a chromogenic substrate for the detection of β-galactosidase activity. It is commonly used in molecular biology techniques such as gene expression analysis and reporter gene analysis. When β-galactosidase cleaves X-Gluc, a blue precipitate is produced, which can be observed by microscopy or other detection methods. X-Gluc has high sensitivity and specificity for the detection of β-galactosidase activity, making it a widely used tool in molecular biology research.

HY-W928283

L-Hydroxyproline 7-amido-4-methylcoumarin hydrochloride

Enzyme Substrates

L-Hydroxyproline 7-amido-4-methylcoumarin hydrochloride is a fluorescent substrate with biological activity for enzyme activity detection. L-Hydroxyproline 7-amido-4-methylcoumarin hydrochloride is often used in biochemical research to detect reactions associated with specific enzymes. L-Hydroxyproline 7-amido-4-methylcoumarin hydrochloride helps scientists monitor the progress of reactions through its fluorescent properties. L-Hydroxyproline 7-amido-4-methylcoumarin hydrochloride has important application value in compound development and basic biological research.

HY-158224

Silk Fibroin Methacryloyl

FibMA

3D Bioprinting

Silk Fibroin Methacryloyl (FibMA) is methacrylated silk fibroin with excellent biocompatibility, stable mechanical properties and good processing properties, and was selected as the substrate for multifunctional microneedle (MN) patches. . MN patches made of Silk Fibroin Methacryloyl exhibit excellent biocompatibility, sustained drug release, pro-angiogenic, antioxidant and antibacterial properties depending on the specific drug encapsulated . Silk Fibroin Methacryloyl needs to self-assemble into fibrous hydrogel under the action of photoinitiator LAP (HY-44076), and target bioactive adhesion sites, play an inherent supporting role for tissue cells and biodegradable activity.
Application: cell culture, biological 3D printing, tissue engineering, etc.

HY-W035133

5,10,15,20-Tetrakis(p-tolyl)porphyrin

5,10,15,20-Tetra-p-tolyl-21H,23H-porphine

Biochemical Assay Reagents

5,10,15,20-Tetrakis(p-tolyl)porphyrin (TTP) is an organic compound belonging to the class of porphyrins, a cyclic molecule composed of four pyrrole rings linked together. TTP is a synthetic porphyrin commonly used as a sensitizer for dye-sensitized solar cells and a catalyst for organic reactions. Due to its unique structure, TTP has a series of interesting properties, including at specific wavelengths and its potential as a catalyst for various chemical reactions. In dye-sensitized solar cells, TTPs help convert sunlight into electricity by absorbing photons and transferring electrons to the semiconductor layer of the device. In organic chemistry, TTP is often used as a catalyst for various organic compounds in reactions such as oxidation and reduction. Its ability to selectively bind certain substrates makes it a useful tool for synthesizing complex molecules and studying their properties.

Cat. No.	Product Name	Target	Research Area

HY-P10620

GGGYK-Biotin	Peptides	Others
GGGYK-Biotin is a substrate peptide designed to study the substrate specificity of Sortase A. GGGYK-Biotin can be used to develop Sortase A variants with different substrate specificities .

HY-P2016

Ac-Nle-Pro-Nle-Asp-AMC	Proteasome	Others
Ac-Nle-Pro-Nle-Asp-AMC is a specific substrate for 26S proteasome. Ac-Nle-Pro-Nle-Asp-AMC can be used for the 26S proteasome caspase-like activity analysis .

HY-P3949

*Fluorescent Substrate* for Glu-Specific Proteases**	Fluorescent Dye	Others
Fluorescent Substrate for Glu-Specific Proteases is a V8 protease-Specific chromogenic substrate .

HY-P0136

SAMS 2 Publications Verification	AMPK	Metabolic Disease
SAMS peptide is a specific substrate for the AMP-activated protein kinase (AMPK).

HY-P10602

PKA Regulatory Subunit II Substrate RII phosphopeptide	Peptides	Others
PKA Regulatory Subunit II Substrate (RII phosphopeptide) is a tool peptide derived from the regulatory subunit Type II (RII) of cyclic AMP-dependent protein kinase (PKA). PKA Regulatory Subunit II Substrate is commonly used to mimic the phosphorylation of protein kinases and as a specific substrate for protein phosphatases to assess the activities of these enzymes .

HY-P10463

ssK36	Histone Methyltransferase	Cancer
ssK36 is a supersubstrate peptide of the histone methyltransferase (SET) domain protein 2 (SETD2), and ssK36 is designed for the SETD2 protein, a specific PKMT. It is responsible in human cells for adding methyl groups to the 36th lysine residue of histone H3 (H3K36) to form H3K36me3. ssK36 can be methylated by SETD2 at a rate more than 100 times faster than the natural substrate H3K36. ssK36 can be used to study the catalytic mechanism of PKMTs, especially substrate specificity and catalytic efficiency .

HY-P5990

Prostate Specific Antigen Substrate	PSMA	Cancer
Prostate Specific Antigen Substrate is a prostate specific antigen (PSA) fluorescent substrate. Prostate Specific Antigen Substrate can be used for detect enzymatic activity of PSA .

HY-P3948

*Fluorescent Substrate* for Pro-Specific Proteases**	Fluorescent Dye	Others
Fluorescent Substrate for Pro-Specific Proteases is a fluorescent substrate of pro-specific proteases. Fluorescent Substrate for Pro-Specific Proteases can be used to detect the hydrolysis rate and activity of target enzyme .

HY-P3950

*Fluorescent Substrate* for Asp-Specific Proteases**	Fluorescent Dye	Others
Fluorescent Substrate for Asp-Specific Proteases is a substrate to cleave specifically the Asp-Val bond .

HY-P2513

Src Optimal Peptide Substrate	Peptides	Others
Src Optimal Peptide Substrate is a highly specific Src substrate. Src Optimal Peptide Substrate can used to measure the Src activity .

HY-P0200

RR-SRC	Src	Inflammation/Immunology
RR-SRC is a substrate for *src-tyrosine-specific* protein kinase** .

HY-P3764

Protein kinase C substrate	PKC	Others
Protein kinase C substrate is a substrate of Protein kinase C, can be used to detect protein. Protein kinase C is a key regulatory element in signal transduction and exerts its effects by catalysing specific substrate phosphorylation .

HY-P1347

RETF-4NA	Peptides	Metabolic Disease
RETF-4NA, a chymase-specific substrate, is a sensitive and selective substrate for chymase when free or bound to α₂M .

HY-P4426

Lys-Pro-AMC	Fluorescent Dye	Others
Lys-Pro-AMC is a fluorogenic substrate for the detection and measurement of the activity of specific enzymes .

HY-P0248

Kemptide	PKA	Metabolic Disease
Kemptide is a synthetic heptapeptide that acts as a specific substrate for cAMP-dependent protein kinase (PKA).

HY-P1347A

RETF-4NA TFA	Peptides	Metabolic Disease
RETF-4NA TFA, a chymase-specific substrate, is a sensitive and selective substrate for chymase when free or bound to α₂M .

HY-P5526

CCK1-specific peptide substrate	Peptides	Others
CCK1-specific peptide substrate is a biological active peptide. (This peptide sequence is based on rabbit muscle glycogen synthase with Ser7 phosphorylated. It is a peptide substrate for Casein Kinase I (CK1). CK1 phosphorylates Ser10. Ser7 is phosphorylated by PKA in vivo.)

HY-P4426A

Lys-Pro-AMC diTFA	Fluorescent Dye	Others
Lys-Pro-AMC diTFA is a fluorogenic substrate for the detection and measurement of the activity of specific enzymes .

HY-P4402

D-Ile-Phe-Lys-pNA	Peptides	Others
D-Ile-Phe-Lys-pNA is a highly specific substrate for human plasmin .

HY-P10002A

EWFW-ACC TFA	Biochemical Assay Reagents	Others
EWFW-ACC TFA is a specific immunoproteasome substrate that can be used to study immunoproteasome function .

HY-P10527

CSK substrate	Src	Others
CSK substrate is a specific substrate for C-terminal Src kinase (CSK), which binds CSK and downregulates the Src family members. CSK substrate preferentially phosphorylates certain amino acid residues that are distinct from the conserved Src C-terminal sequence .

HY-P3126

Suc-Ile-Glu(γ-pip)-Gly-Arg-pNA hydrochloride	Factor Xa	Others
Suc-Ile-Glu(γ-pip)-Gly-Arg-pNA hydrochloride is a factor Xa specific chromogenic substrate .

HY-123051

Ac-WLA-AMC	Proteasome	Inflammation/Immunology
Ac-WLA-AMC is a specific 20S constitutive proteasome β5 fluorogenic substrate .

HY-P3743

p60c-src Substrate	Src Peptides	Others
p60c-src Substrate is an efficient and specific substrate for p60c-src protein tyrosine kinase (PTK). p60c-src Substrate can be used to synthesize chimeric branched peptides .

HY-P0291

Kemptide Phospho-Ser5	PKA	Others
Kemptide (Phospho-Ser5) is a phosphate acceptor peptide that serves as a specific substrate for cAMP-dependent protein kinase (PKA).

HY-P2208

Z-IETD-AFC	Fluorescent Dye	Cancer
Z-IETD-AFC, a specific fluorescence substrate, can be used to determine the caspase-8 catalytic activity .

HY-P3818

PKCδ Peptide Substrate	PKC	Others
PKCδ Peptide Substrate is an absolutely specific substrate for the δ-type of PKC, with a sequence corresponding to sequence 422-443 of murine eEF-1α and containing Thr-431 .

HY-P10073

Calpain-1 substrate, fluorogenic	Fluorescent Dye	Others
Calpain-1 substrate, fluorogenic serves as a sensitive and specific substrate for calpain-1 that cleaves Tyr-Gly bond and results in enhanced fluorescence .(Ex/Em = 490 nm/518 nm)

HY-P4209

Boc-GRR-AMC	Peptides	Others
Boc-GRR-AMC is a tri-peptide Substrate. Boc-GRR-AMC can be used for a fluorogenic West Nile virus (WNV) substrate, profiling the substrate specificity for the NS2B-NS3 proteases or determining the pH optimum of LdMC activity .

HY-P4209A

Boc-GRR-AMC TFA	Peptides	Others
Boc-GRR-AMC (TFA) is a tri-peptide Substrate. Boc-GRR-AMC can be used for a fluorogenic West Nile virus (WNV) substrate, profiling the substrate specificity for the NS2B-NS3 proteases or determining the pH optimum of LdMC activity .

HY-P5374

MeOSuc-AAPV-AFC	Peptides	Others
MeOSuc-AAPV-AFC is a biological active peptide. (A highly specific neutrophil elastase substrate, Abs/Em=380/500 nm.)

HY-P0019

Z-Gly-Gly-Arg-AMC Maximum Cited Publications 9 Publications Verification	Fluorescent Dye	Cardiovascular Disease
Z-Gly-Gly-Arg-AMC is a thrombin-specific fluorogenic substrate for testing of thrombin generation in PRP and platelet-poor plasma (PPP).

HY-P0019A

Z-Gly-Gly-Arg-AMC acetate Maximum Cited Publications 9 Publications Verification	Fluorescent Dye	Others
Z-Gly-Gly-Arg-AMC acetate is a thrombin-specific fluorogenic substrate for testing of thrombin generation in PRP and platelet-poor plasma (PPP).

HY-P0266

N-Acetyl-Ser-Asp-Lys-Pro Ac-SDKP	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease Inflammation/Immunology
N-Acetyl-Ser-Asp-Lys-Pro, an endogenous tetrapeptide secreted by bone marrow, is a specific substrate for the N-terminal site of ACE.

HY-111956

D-Ala-Lys-AMCA	Fluorescent Dye	Cancer
D-Ala-Lys-AMCA is a known proton-coupled oligopeptide transporter 1 (PEPT1) substrate that emits blue fluorescence. D-Ala-Lys-AMCA may be transported into liver cancer cells and Caco-2 cells based on fluorescence analysis. D-Ala-Lys-AMCA can be used for characterizing PEPT1-specific substrates or inhibitors .

HY-P1803

Protein Kinase C Peptide Substrate PKCε; PRKCE ; Peptide Epsilon	Peptides	Neurological Disease Inflammation/Immunology Endocrinology
Protein Kinase C Peptide Substrate is targeted to a specific cellular compartment in a manner dependent on second messengers and on specific adapter proteins in response to extracellular signals that activate G-protein-coupled receptors, tyrosine kinase receptors, or tyrosine kinase-coupled receptors. Protein Kinase C Peptide Substrate then regulates various physiological functions including the activation of nervous, endocrine, exocrine, inflammatory, and immune systems .

HY-111956B

D-Ala-Lys-AMCA hydrochloride 1 Publications Verification	Fluorescent Dye	Cancer
D-Ala-Lys-AMCA hydrochloride is a known proton-coupled oligopeptide transporter 1 (PEPT1) substrate that emits blue fluorescence. D-Ala-Lys-AMCA hydrochloride may be transported into liver cancer cells and Caco-2 cells based on fluorescence analysis. D-Ala-Lys-AMCA hydrochloride can be used for characterizing PEPT1-specific substrates or inhibitors .

HY-P4773

HSV-1 Protease substrate	HSV	Infection
HSV-1 Protease substrate is a peptide substrate for HSV-1 (Herpes Simplex Virus Type 1) protease, and the specificity constant (k_cat/K_m) at pH 7.5 for cleavage is 5.2 M ^-1 s ^-1 .

HY-P0266A

N-Acetyl-Ser-Asp-Lys-Pro TFA Ac-SDKP TFA	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease Inflammation/Immunology
N-Acetyl-Ser-Asp-Lys-Pro (TFA), an endogenous tetrapeptide secreted by bone marrow, is a specific substrate for the N-terminal site of ACE.

HY-111956A

D-Ala-Lys-AMCA TFA	Fluorescent Dye	Cancer
D-Ala-Lys-AMCA TFA is a known proton-coupled oligopeptide transporter 1 (PEPT1) substrate that emits blue fluorescence. D-Ala-Lys-AMCA TFA may be transported into liver cancer cells and Caco-2 cells based on fluorescence analysis. D-Ala-Lys-AMCA TFA can be used for characterizing PEPT1-specific substrates or inhibitors .

HY-P1597

Malantide 1 Publications Verification	PKA PKC	Cancer
Malantide is a synthetic dodecapeptide derived from the site phosphorylated by cAMP-dependent protein kinase (PKA) on the β-subunit of phosphorylase kinase. Malantide is a highly specific substrate for PKA with a K_m of 15 μM and shows protein inhibitor (PKI) inhibition >90% substrate phosphorylation in various rat tissue extracts . Malantide is also an efficient substrate for PKC with a K_m of 16 μM .

HY-P4524

FA-Phe-Phe	Angiotensin-converting Enzyme (ACE)	Others
FA-Phe-Phe is a furylacryloyl (fa)-amino acid derivative, targeting to Angiotensin-converting Enzyme (ACE). FA-Phe-Phe is also a specific substrate of Cathepsin A .

HY-P2008

Boc-Ile-Glu-Gly-Arg-AMC 1 Publications Verification IEGR-AMC	Factor Xa	Cardiovascular Disease
Boc-Ile-Glu-Gly-Arg-AMC (IEGR-AMC) is an activated factor X (FXa) specific fluorogenic peptide substrate used for Factor VIII determination .

HY-P10346

smMLCK peptide Smooth-Muscle Myosin Light-Chain Kinase (796-815)	Peptides	Cardiovascular Disease Inflammation/Immunology
smMLCK peptide is a specific inhibitor of smooth muscle myosin light chain kinase (smMLCK). The smMLCK peptide mimics the substrate and competitively inhibits the binding of the actual substrate to the enzyme, thereby inhibiting the kinase activity. This inhibition prevents the phosphorylation of the myosin light chain, thus inhibiting muscle contraction .

HY-P1597A

Malantide TFA	PKA PKC	Cancer
Malantide TFA is a synthetic dodecapeptide derived from the site phosphorylated by cAMP-dependent protein kinase (PKA) on the β-subunit of phosphorylase kinase. Malantide TFA is a highly specific substrate for PKA with a K_m of 15 μM and shows protein inhibitor (PKI) inhibition >90% substrate phosphorylation in various rat tissue extracts . Malantide TFA is also an efficient substrate for PKC with a K_m of 16 μM .

HY-P3907

Kemptide (amide)	Peptides	Others
Kemptide (amide) is a heptapeptide with properties of a cytophilic substrate. Kemptide is a molecule preserving cell membrane intactness, is phosphorylated by PKI, the inhibitory protein specific for cAMP-dependent protein kinase (PK) .

HY-P5430

DYRKtide	Peptides	Others
DYRKtide is a biological active peptide. (Dyrktide is designed as the optimal substrate sequence efficiently phosphorylated by DYRK1A, which is a dual-specificity protein kinase that is thought to be involved in brain development.)

HY-P2536

Mca-Ala-Pro-Lys(Dnp)-OH	Angiotensin-converting Enzyme (ACE)	Others
Mca-Ala-Pro-Lys(Dnp)-OH, a specific ACE2 quenched fluorogenic substrate, can be used to detect ACE2 activity, such as urinary, heart and lung .

HY-P0136F

FAM-SAMS	Peptides	Others
FAM-SAMS is a 5-FAM (HY-66022) labeled SAMS (HY-P0136). SAMS peptide is a specific substrate for the AMP-activated protein kinase (AMPK) .

HY-P0136AF

FAM-SAMS TFA	Fluorescent Dye	Others
FAM-SAMS TFA is a 5-FAM (HY-66022) labeled SAMS (HY-P0136). SAMS peptide is a specific substrate for the AMP-activated protein kinase (AMPK) .

Cat. No.	Product Name		Classification

HY-W353804

2′-Deoxy-β-L-uridine		Nucleosides and their Analogs
2'-Deoxy-β-L-uridine is a nucledside analogue and a specific substrate for the viral enzyme, shows no stereospecificity against herpes simplex 1 (HSV1) thymidine kinase (TK). 2′-Deoxy-β-L-uridine exerts antiviral activity via the interation of 5'-triphosphates with the viral DNA polymerase .

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