2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. O-Acetylserine

O-Acetylserine  (Synonyms: O-Acetyl-L-serine)

Cat. No.: HY-101409 Purity: ≥98.0%
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O-Acetylserine (O-Acetyl-L-serine) is an intermediate in the biosynthesis of the amino acid cysteine in bacteria and plants.

For research use only. We do not sell to patients.

O-Acetylserine Chemical Structure

O-Acetylserine Chemical Structure

CAS No. : 5147-00-2

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Based on 1 publication(s) in Google Scholar

Other Forms of O-Acetylserine:

O-Acetylserine Related Antibodies

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  • Purity & Documentation

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Description

O-Acetylserine (O-Acetyl-L-serine) is an intermediate in the biosynthesis of the amino acid cysteine in bacteria and plants.

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

O-acetylserine (OAS) is a central metabolite of sulfur assimilation, providing the carbon backbone for synthesis of cysteine. Sulfide generated through sulfate reduction is incorporated into OAS to form cysteine. OAS displays a signalling function leading to changes in transcript levels of a specific gene set irrespective of the sulfur status of the plant[1].
Treatment with external OAS increases sulfate transporter and adenosine 5′-phosphosulfate reductase gene expression consistent with a model of transcriptional induction by OAS[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

O-Acetylserine Related Antibodies
Molecular Weight

147.13

Formula

C5H9NO4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

N[C@@H](COC(C)=O)C(O)=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (339.84 mM; Need ultrasonic)

DMSO : 6.25 mg/mL (42.48 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 6.7967 mL 33.9836 mL 67.9671 mL
5 mM 1.3593 mL 6.7967 mL 13.5934 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 0.62 mg/mL (4.21 mM); Clear solution

    This protocol yields a clear solution of ≥ 0.62 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (6.2 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 0.62 mg/mL (4.21 mM); Clear solution

    This protocol yields a clear solution of ≥ 0.62 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (6.2 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (679.67 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 6.7967 mL 33.9836 mL 67.9671 mL 169.9178 mL
5 mM 1.3593 mL 6.7967 mL 13.5934 mL 33.9836 mL
10 mM 0.6797 mL 3.3984 mL 6.7967 mL 16.9918 mL
15 mM 0.4531 mL 2.2656 mL 4.5311 mL 11.3279 mL
20 mM 0.3398 mL 1.6992 mL 3.3984 mL 8.4959 mL
25 mM 0.2719 mL 1.3593 mL 2.7187 mL 6.7967 mL
30 mM 0.2266 mL 1.1328 mL 2.2656 mL 5.6639 mL
40 mM 0.1699 mL 0.8496 mL 1.6992 mL 4.2479 mL
H2O 50 mM 0.1359 mL 0.6797 mL 1.3593 mL 3.3984 mL
60 mM 0.1133 mL 0.5664 mL 1.1328 mL 2.8320 mL
80 mM 0.0850 mL 0.4248 mL 0.8496 mL 2.1240 mL
100 mM 0.0680 mL 0.3398 mL 0.6797 mL 1.6992 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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O-Acetylserine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

O-Acetylserine5147-00-2O-Acetyl-L-serineEndogenous MetaboliteInhibitorinhibitorinhibit

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