Bax - BCL2 associated X, apoptosis regulator Gene

Rattus norvegicus

Gene ID: 24887 | Gene type: protein coding

About Bax

Primary_assembly 1: 95,938,808-95,945,368 reverse strand.mRatBN7.2:CM026974.1

This gene has 1 transcript (splice variant), 204 orthologues, 13 paralogues and is associated with 97 phenotypes. Biased expression in Spleen (RPKM 111.1), Thymus (RPKM 15.) and 9 other tissues.

Summary

Enables BH domain binding activity; chaperone binding activity; and heat shock protein binding activity. Involved in several processes, including glial cell apoptotic process; mitochondrion organization; and response to corticosterone. Located in cytosol; mitochondrial outer membrane; and perinuclear region of cytoplasm. Used to study brain glioma; endometriosis; morphine dependence; and pre-malignant neoplasm. Biomarker of several diseases, including abdominal obesity-metabolic syndrome 1; artery disease (multiple); brain disease (multiple); heart disease (multiple); and neurodegenerative disease (multiple). Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; ataxia telangiectasia; colon adenocarcinoma; colorectal cancer; and lung non-small cell carcinoma. Orthologous to human Bax (BCL2 associated X, Apoptosis regulator). [provided by Alliance of Genome Resources, Apr 2022]

Bax Products(1)

mRNA	Protein	Name
NM_017059.2	NP_058755.2	apoptosis regulator BAX

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables BH domain binding	IPI IPI: Inferred from physical interaction	9356461	RGD
enables heat shock protein binding	IPI IPI: Inferred from physical interaction	12070120	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	15004018	RGD
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	9356461	RGD
enables protein-folding chaperone binding	IPI IPI: Inferred from physical interaction	12070120	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular respiration	IDA IDA: Inferred from direct assay	12460673	RGD
involved in cellular response to hydrogen peroxide	IEP IEP: Inferred from expression pattern	25726415	RGD
involved in cerebral cortex development	IEP IEP: Inferred from expression pattern	9813151	RGD
involved in glial cell apoptotic process	IEP IEP: Inferred from expression pattern	18931364	RGD
involved in inner mitochondrial membrane organization	IDA IDA: Inferred from direct assay	12460673	RGD
involved in outer mitochondrial membrane organization	IDA IDA: Inferred from direct assay	12460673	RGD
involved in ovarian follicle development	IEP IEP: Inferred from expression pattern	17570453	RGD
involved in positive regulation of apoptotic process	IDA IDA: Inferred from direct assay	9804769	RGD
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	20385067	RGD
involved in release of cytochrome c from mitochondria	IDA IDA: Inferred from direct assay	10724126	RGD
involved in response to cocaine	IEP IEP: Inferred from expression pattern	17084983	RGD
involved in response to copper ion	IEP IEP: Inferred from expression pattern	18289470	RGD
involved in response to corticosterone	IEP IEP: Inferred from expression pattern	17562391	RGD
involved in response to hypoxia	IEP IEP: Inferred from expression pattern	24089674	RGD
involved in response to ischemia	IEP IEP: Inferred from expression pattern	31583047	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	17784886	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in mitochondrial membrane	IDA IDA: Inferred from direct assay	10724126	RGD
located in mitochondrial outer membrane	IDA IDA: Inferred from direct assay	15044178	RGD
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	11299004	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Bax Protein Structure

bcl-2

0
100
192 a.a.

Protein Preferred Names

Protein Names

apoptosis regulator BAX

Bcl2-associated X protein

Related Agents

Approval

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B1192	Estradiol benzoate		99.89%	Unkown
HY-B0402	Amantadine	Modulator	99.90%	Unkown
HY-B1357	Digitoxin		99.36%	Yes
HY-B0402A	Amantadine hydrochloride	Modulator	≥98.0%	Yes
HY-B0621	Triclabendazole		98.72%	Yes
HY-B0402B	Amantadine sulfate	Modulator	/	Unkown

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-13755	Sulforaphane	Inhibitor	99.75%	Phase 4
HY-13560	AVN-944	Modulator	99.77%	Phase 2

Pre-clinical Phase

Bioactive Molecules (56)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-107202	Polyinosinic-polycytidylic acid		99.40%	Unkown
HY-13594	Chlorin e6		98.38%	Unkown
HY-103269	BAI1	Inhibitor	99.89%	Unkown
HY-N0674	Dehydrocorydaline	Modulator	99.77%	Unkown
HY-N0361	Dihydrocapsaicin	Modulator	99.93%	Unkown
HY-P0081	Bax inhibitor peptide V5	Inhibitor	99.77%	Unkown
HY-120079	MSN-125	Inhibitor	99.00%	Unkown
HY-123054	BTSA1	Activator	99.49%	Unkown
HY-B1971	Deltamethrin		99.93%	Unkown
HY-N6626	Pyraclostrobin		99.91%	Unkown
HY-N0060B	(E)-Ferulic acid	Activator	99.89%	Unkown
HY-13108	Bz 423	Activator	99.72%	Unkown
HY-13755A	(R)-Sulforaphane	Inhibitor	99.48%	Unkown
HY-P1928	Humanin	Inhibitor	99.83%	Unkown
HY-N0831	Jaceosidin	Activator	99.51%	Unkown
HY-118948	MSN-50	Inhibitor	98.68%	Unkown
HY-W082785A	L6H21	Modulator	99.46%	Unkown
HY-126437	Poly-L-lysine (hydrobromide) (MW 30000-70000)	Inhibitor	/	Unkown
HY-157176	BAX-IN-1	Inhibitor	≥98.0%	Unkown
HY-15341	BAM7	Activator	98.53%	Unkown
HY-132173	GL0388	Activator	98.01%	Unkown
HY-108164	Aspidin BB	Modulator	98.08%	Unkown
HY-N1157	Thevetiaflavone	Modulator	≥98.0%	Unkown
HY-122760	Bax activator-1	Activator	98.45%	Unkown
HY-N9802	n-Butyl-β-D-fructofuranoside	Activator	≥97.0%	Unkown
HY-147889	BBR-BODIPY	Activator	98.15%	Unkown
HY-N0905	Ginsenoside Rh4	Activator	99.28%	Unkown
HY-146105	Anticancer agent 65	Modulator	/	Unkown
HY-N0831R	Jaceosidin (Standard)	Activator	/	Unkown
HY-170929	EMT inhibitor-3		/	Unkown
HY-161659	Apoptosis inducer 19	Modulator	/	Unkown
HY-168623	EGFR-IN-134	Inhibitor	/	Unkown
HY-151428	Antitumor agent-78	Inhibitor	/	Unkown
HY-147929	Apoptotic agent-3	Activator	/	Unkown
HY-148368	CYD-4-61	Activator	/	Unkown
HY-168877	FMP		/	Unkown
HY-146253	CDK1/2/4-IN-1	Activator	/	Unkown
HY-168739	Topoisomerase I inhibitor 17	Activator	/	Unkown
HY-170912	Topo I/II-IN-2		/	Unkown
HY-126311	4-Hydroxyresveratrol	Inducer	/	Unkown
HY-144792	Bcl-2-IN-7	Modulator	/	Unkown
HY-147928	Apoptotic agent-2	Activator	/	Unkown
HY-101996	SMBA1	Agonist	/	Unkown
HY-146548	Anticancer agent 43	Inducer	98.58%	Unkown
HY-144791	Bcl-2-IN-6	Modulator	/	Unkown
HY-143235	BRD4 Inhibitor-15	Modulator	/	Unkown
HY-147514	Anticancer agent 64	Modulator	/	Unkown
HY-117652	Lobetyol	Modulator	/	Unkown
HY-N10313	Dehydrobruceine B	Modulator	/	Unkown
HY-151429	Antitumor agent-77	Inhibitor	/	Unkown
HY-162360	EGFR-IN-109	Inhibitor	/	Unkown
HY-P3148	Astin B	Modulator	/	Unkown
HY-150540	Bcl-2-IN-10	Inhibitor	/	Unkown
HY-N8508	Myrothecine A	Inducer	/	Unkown
HY-119682	Bax agonist 1		/	Unkown
HY-122481	Thaspine acetate		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Bax	NCBI	NCBI:581

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