2. Gene
  3. PGP - phosphoglycolate phosphatase Gene

PGP - phosphoglycolate phosphatase Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as AUM; G3PP; PGPase

Gene ID: 283871 | Gene type: protein coding

About PGP

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:2,211,593-2,214,840 (from NCBI)

This gene has 2 transcripts (splice variants), 211 orthologues and 3 paralogues. Broad expression in testis (RPKM 12.7), brain (RPKM 7.6) and 25 other tissues.

Summary

Enables glycerol-3-phosphatase activity and phosphoglycolate Phosphatase activity. Involved in glycerol biosynthetic process; glycerophospholipid metabolic process; and negative regulation of gluconeogenesis. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

PGP Products(1)

mRNA Protein Name
NM_001042371.3 NP_001035830.1 glycerol-3-phosphate phosphatase
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables glycerol-3-phosphatase activity IDA
IDA: Inferred from direct assay
26755581 GOA
enables phosphoglycolate phosphatase activity IDA
IDA: Inferred from direct assay
26755581 GOA
Biological Process GO Annotation Evidence Reference Source
involved in glycerol biosynthetic process IDA
IDA: Inferred from direct assay
26755581 GOA
involved in glycerophospholipid metabolic process IDA
IDA: Inferred from direct assay
26755581 GOA
involved in negative regulation of gluconeogenesis IMP
IMP: Inferred from mutant phenotype
26755581 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PGP Protein Structure

Hydrolase_6

Hydrolase_6: Haloacid dehalogenase-like hydrolase (31 - 138)

Hydrolase_like

Hydrolase_like: HAD-hyrolase-like (233 - 315)

  • 0
  • 100
  • 200
  • 300
  • 321 a.a.
Protein Preferred Names Protein Names

glycerol-3-phosphate phosphatase

aspartate-based ubiquitous Mg(2+)-dependent phosphatase

Related Diseases

Diseases Alias
Sennetsu Fever

Sennetsu Ehrlichiosis

Human Ehrlichial Infection, Sennetsu Type
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Approval
Bioactive Molecules (12)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-14275 Verapamil 99.96% Yes
HY-10440 Vismodegib 99.97% Yes
HY-A0064 Verapamil hydrochloride 99.98% Yes
HY-17367A Atazanavir sulfate 99.94% Yes
HY-B0777 Moxidectin Inhibitor 99.32% Yes
HY-17367 Atazanavir 99.86% Yes
HY-145574 Iruplinalkib Inhibitor 99.29% Unkown
HY-N7120 Penicillin G procaine hydrate Inhibitor 99.52% Unkown
HY-B0501 Danofloxacin mesylate Inhibitor 99.87% Unkown
HY-16397 Phenformin 99.72% Unkown
HY-A0064R Verapamil hydrochloride (Standard) / Unkown
HY-B0777R Moxidectin (Standard) Inhibitor / Unkown
Clinical Phase
Bioactive Molecules (12)
Cat. No. Product Name Effect
Purity Phase
HY-10550 Tariquidar Inhibitor 99.45% Phase 3
HY-50671 Zosuquidar trihydrochloride Inhibitor 99.79% Phase 3
HY-15255 Zosuquidar Inhibitor 99.90% Phase 3
HY-10550A Tariquidar methanesulfonate, hydrate Inhibitor 98.52% Phase 3
HY-110377 Tariquidar dihydrochloride Inhibitor / Phase 3
HY-19642A Glesatinib hydrochloride Inhibitor 98.01% Phase 2
HY-106004 Zamicastat Inhibitor ≥98.0% Phase 2
HY-19642 Glesatinib Inhibitor / Phase 2
HY-132189 Laniquidar Inhibitor / Phase 2
HY-16773 Vedroprevir Inhibitor / Phase 2
HY-50879 Elacridar Inhibitor 99.94% Phase 1
HY-17013A Dofequidar fumarate Inhibitor ≥98.0% Phase 1
Pre-clinical Phase
Bioactive Molecules (103)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-10010 Ko 143 Inhibitor 99.97% Unkown
HY-13925 PD0166285 99.46% Unkown
HY-50880 Elacridar hydrochloride Inhibitor 99.93% Unkown
HY-N6684 Deoxynivalenol 99.39% Unkown
HY-N3584 Paris saponin VII 99.96% Unkown
HY-108694 γ-Tocotrienol Inhibitor 99.73% Unkown
HY-107643 Reversan Inhibitor 99.90% Unkown
HY-N1941 Isosinensetin Inhibitor 99.65% Unkown
HY-N2453 Convallatoxin 98.66% Unkown
HY-W009141 1-Monopalmitin Inhibitor 99.42% Unkown
HY-100750 Norverapamil hydrochloride Inhibitor 99.80% Unkown
HY-108286 Talinolol Antagonist 99.64% Unkown
HY-161246 uPSEM792 99.92% Unkown
HY-N6932 Voacamine 99.64% Unkown
HY-14942 Berubicin 87.76% Unkown
HY-113805 MC70 Inhibitor 99.50% Unkown
HY-119823 PGP-4008 Inhibitor 99.69% Unkown
HY-N2103 Tenacissoside G 99.64% Unkown
HY-119101 AZD-5672 95.74% Unkown
HY-W001601 Budipine Antagonist 99.41% Unkown
HY-101791 P-gp inhibitor 1 Inhibitor 98.79% Unkown
HY-19626 NSC23925 Inhibitor 99.43% Unkown
HY-126940 Furanodiene 99.65% Unkown
HY-132866 YS-370 Inhibitor 98.50% Unkown
HY-A0064S Verapamil-d3 hydrochloride 99.57% Unkown
HY-N0689 Evodine Inhibitor 99.20% Unkown
HY-N1457 Chrysosplenetin 99.75% Unkown
HY-N4108 Hypophyllanthin Inhibitor 98.84% Unkown
HY-N6748 Roquefortine C 98.42% Unkown
HY-143792 HTT-D3 Inhibitor / Unkown
HY-162753 ZW-1226 98.13% Unkown
HY-N2416 Taccalonolide A 99.29% Unkown
HY-N3028 Taccalonolide B Inhibitor 98.59% Unkown
HY-162373 α-Amylase/α-Glucosidase-IN-10 Inhibitor / Unkown
HY-112912 P-gp modulator 1 / Unkown
HY-130244 BACE1-IN-5 Inhibitor / Unkown
HY-10550B Tariquidar dimesylate Inhibitor / Unkown
HY-128685 FD 12-9 Inhibitor / Unkown
HY-146096 RMS3 / Unkown
HY-146097 RMS5 / Unkown
HY-149053 OY-101 Inhibitor / Unkown
HY-17367S2 Atazanavir-d9 / Unkown
HY-17367S3 Atazanavir-d5 / Unkown
HY-106753 Tolnapersine / Unkown
HY-108286S (Rac)-Talinolol-d5 Antagonist / Unkown
HY-121247 Bromotetrandrine / Unkown
HY-135328 Norverapamil Inhibitor / Unkown
HY-135328AS Norverapamil-d7 hydrochloride Antagonist 98.77% Unkown
HY-135328S Norverapamil-d7 Inhibitor / Unkown
HY-13925A PD0166285 dihydrochloride / Unkown
HY-14275S1 Verapamil-d7 / Unkown
HY-144366 P-gp inhibitor 3 Inhibitor / Unkown
HY-144393 P-gp/BCRP-IN-1 Inhibitor / Unkown
HY-146117 P-gp modulator 2 Modulator / Unkown
HY-146118 P-gp modulator 3 Modulator / Unkown
HY-146391 P-gp inhibitor 4 Modulator / Unkown
HY-147758 BACE1/2-IN-1 Inhibitor / Unkown
HY-149053B (R)-OY-101 / Unkown
HY-149240 Anticancer agent 108 Inhibitor / Unkown
HY-149277 FM04 Inhibitor / Unkown
HY-149360 P-gb-IN-1 Inhibitor / Unkown
HY-149813 P-gp inhibitor 14 Inhibitor / Unkown
HY-149981 P-gp inhibitor 13 Inhibitor / Unkown
HY-150565 P-gp inhibitor 5 Inhibitor / Unkown
HY-152079 CYP1B1-IN-3 Inhibitor / Unkown
HY-155032 P-gp inhibitor 15 Inhibitor / Unkown
HY-155391 hCA/Wnt/β-catenin-IN-1 Inhibitor 99.96% Unkown
HY-157330 P-gp inhibitor 16 / Unkown
HY-157483 P-gp inhibitor 18 Inhibitor / Unkown
HY-157484 P-gp inhibitor 19 Inhibitor / Unkown
HY-157876 Anticancer agent 191 Inhibitor / Unkown
HY-158236 ORL1 antagonist 2 Antagonist / Unkown
HY-158435 P-gp inhibitor 23 Inhibitor / Unkown
HY-159085 P-gp inhibitor 24 Inhibitor / Unkown
HY-159614 PG-PS Activator / Unkown
HY-161260 P-gp inhibitor 20 Inhibitor / Unkown
HY-161645 P-gp modulator-4 Modulator / Unkown
HY-161776 P-gp/CDK2-IN-1 Inhibitor / Unkown
HY-162040 P-gp inhibitor 17 Inhibitor / Unkown
HY-162369 PID-9 Inhibitor / Unkown
HY-162396 P-gp inhibitor 21 Inhibitor / Unkown
HY-162447 P-gp inhibitor 22 / Unkown
HY-162822 P-gp modulator-5 Modulator / Unkown
HY-163204 RhQ-DMB Inhibitor / Unkown
HY-168008 P-gp inhibitor 25 Inhibitor / Unkown
HY-168186 P-gp inhibitor 26 Inhibitor / Unkown
HY-A0064S1 Verapamil-d6 hydrochloride / Unkown
HY-N10562 Mutabilol Modulator / Unkown
HY-N10563 Coleon-U-quinone Inhibitor / Unkown
HY-N10564 8α,9α-Epoxycoleon-U-quinone Modulator / Unkown
HY-N144114 P-gp inhibitor 2 Inhibitor / Unkown
HY-RS10394 PGP Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-W140488 1,2-Didecanoyl-sn-glycero-3-phosphoethanolamine / Unkown
HY-121196 Achillin / Unkown
HY-123934 VU6007477 Modulator / Unkown
HY-13646B Encequidar hydrochloride Inhibitor / Unkown
HY-B0777S Moxidectin-d3 Inhibitor / Unkown
HY-N13157 11α-O-Benzoyl-12β-O-acetyltenacigenin B Inhibitor / Unkown
HY-N7305 Jatrophane 5 Inhibitor / Unkown
HY-N7332 Pepluanin A Inhibitor / Unkown
HY-W700684 N-Didesmethyl Loperamide / Unkown
HY-W854295 Phosphatidylinositol-1,2-dioctanoyl sodium Inhibitor / Unkown
HY-U00247 MCI826 Agonist / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus PGP VGNC VGNC:32798
Macaca mulatta PGP VGNC VGNC:104745
Mus musculus PGP MGD MGI:1914328
Felis catus PGP VGNC VGNC:80673
Rattus norvegicus PGP RGD RGD:1307773
Macaca fascicularis PGP NCBI NCBI:102115347
Others PGP NCBI