2. Gene
  3. HNRNPH1 - heterogeneous nuclear ribonucleoprotein H1 Gene

HNRNPH1 - heterogeneous nuclear ribonucleoprotein H1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as HNRPH; HNRPH1; NEDCDS; hnRNPH

Gene ID: 3187 | Gene type: protein coding

About HNRNPH1

Cytogenetic location: 5q35.3 Genomic coordinates (GRCh38): 5:179,614,178-179,634,784 (from NCBI)

This gene has 50 transcripts (splice variants), 1 gene allele, 143 orthologues, 8 paralogues and is associated with 2 phenotypes. Ubiquitous expression in bone marrow (RPKM 153.8), lymph node (RPKM 101.7) and 25 other tissues.

Summary

This gene encodes a member of a subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins that complex with heterogeneous nuclear RNA. These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some may shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that bind to RNA and is very similar to the family member HNRPF. This gene may be associated with hereditary lymphedema type I. Alternatively spliced transcript variants have been described [provided by RefSeq, Mar 2012]

HNRNPH1 Products(52)

mRNA Protein Name
NM_001257293.2 NP_001244222.1 heterogeneous nuclear ribonucleoprotein H isoform a
NM_001363572.2 NP_001350501.1 heterogeneous nuclear ribonucleoprotein H isoform b
NM_001364225.2 NP_001351154.1 heterogeneous nuclear ribonucleoprotein H isoform c
NM_001364226.2 NP_001351155.1 heterogeneous nuclear ribonucleoprotein H isoform c
NM_001364227.2 NP_001351156.1 heterogeneous nuclear ribonucleoprotein H isoform c
NM_001364228.2 NP_001351157.1 heterogeneous nuclear ribonucleoprotein H isoform c
NM_001364229.2 NP_001351158.1 heterogeneous nuclear ribonucleoprotein H isoform c
NM_001364230.2 NP_001351159.1 heterogeneous nuclear ribonucleoprotein H isoform d
NM_001364231.2 NP_001351160.1 heterogeneous nuclear ribonucleoprotein H isoform l
NM_001364232.2 NP_001351161.1 heterogeneous nuclear ribonucleoprotein H isoform d
NM_001364233.2 NP_001351162.1 heterogeneous nuclear ribonucleoprotein H isoform a
NM_001364234.2 NP_001351163.1 heterogeneous nuclear ribonucleoprotein H isoform a
NM_001364235.2 NP_001351164.1 heterogeneous nuclear ribonucleoprotein H isoform a
NM_001364236.2 NP_001351165.1 heterogeneous nuclear ribonucleoprotein H isoform a
NM_001364237.2 NP_001351166.1 heterogeneous nuclear ribonucleoprotein H isoform a
NM_001364238.2 NP_001351167.1 heterogeneous nuclear ribonucleoprotein H isoform a
NM_001364239.2 NP_001351168.1 heterogeneous nuclear ribonucleoprotein H isoform a
NM_001364240.2 NP_001351169.1 heterogeneous nuclear ribonucleoprotein H isoform e
NM_001364241.2 NP_001351170.1 heterogeneous nuclear ribonucleoprotein H isoform f
NM_001364242.2 NP_001351171.1 heterogeneous nuclear ribonucleoprotein H isoform f
NM_001364243.2 NP_001351172.1 heterogeneous nuclear ribonucleoprotein H isoform f
NM_001364244.2 NP_001351173.1 heterogeneous nuclear ribonucleoprotein H isoform g
NM_001364245.2 NP_001351174.1 heterogeneous nuclear ribonucleoprotein H isoform b
NM_001364246.2 NP_001351175.1 heterogeneous nuclear ribonucleoprotein H isoform t
NM_001364247.2 NP_001351176.1 heterogeneous nuclear ribonucleoprotein H isoform t
NM_001364248.2 NP_001351177.1 heterogeneous nuclear ribonucleoprotein H isoform h
NM_001364250.2 NP_001351179.1 heterogeneous nuclear ribonucleoprotein H isoform i
NM_001364251.2 NP_001351180.1 heterogeneous nuclear ribonucleoprotein H isoform j
NM_001364252.2 NP_001351181.1 heterogeneous nuclear ribonucleoprotein H isoform j
NM_001364253.2 NP_001351182.1 heterogeneous nuclear ribonucleoprotein H isoform j
NM_001364254.2 NP_001351183.1 heterogeneous nuclear ribonucleoprotein H isoform k
NM_001364255.2 NP_001351184.1 heterogeneous nuclear ribonucleoprotein H isoform k
NM_001395176.1 NP_001382105.1 heterogeneous nuclear ribonucleoprotein H isoform l
NM_001395177.1 NP_001382106.1 heterogeneous nuclear ribonucleoprotein H isoform m
NM_001395178.1 NP_001382107.1 heterogeneous nuclear ribonucleoprotein H isoform n
NM_001395179.1 NP_001382108.1 heterogeneous nuclear ribonucleoprotein H isoform o
NM_001395180.1 NP_001382109.1 heterogeneous nuclear ribonucleoprotein H isoform o
NM_001395181.1 NP_001382110.1 heterogeneous nuclear ribonucleoprotein H isoform p
NM_001395182.1 NP_001382111.1 heterogeneous nuclear ribonucleoprotein H isoform a
NM_001395183.1 NP_001382112.1 heterogeneous nuclear ribonucleoprotein H isoform q
NM_001395184.1 NP_001382113.1 heterogeneous nuclear ribonucleoprotein H isoform r
NM_001395186.1 NP_001382115.1 heterogeneous nuclear ribonucleoprotein H isoform f
NM_001395187.1 NP_001382116.1 heterogeneous nuclear ribonucleoprotein H isoform g
NM_001395188.1 NP_001382117.1 heterogeneous nuclear ribonucleoprotein H isoform s
NM_001395189.1 NP_001382118.1 heterogeneous nuclear ribonucleoprotein H isoform b
NM_001395190.1 NP_001382119.1 heterogeneous nuclear ribonucleoprotein H isoform u
NM_001395191.1 NP_001382120.1 heterogeneous nuclear ribonucleoprotein H isoform v
NM_001395192.1 NP_001382121.1 heterogeneous nuclear ribonucleoprotein H isoform w
NM_001395193.1 NP_001382122.1 heterogeneous nuclear ribonucleoprotein H isoform x
NM_001395194.1 NP_001382123.1 heterogeneous nuclear ribonucleoprotein H isoform k
NM_001395195.1 NP_001382124.1 heterogeneous nuclear ribonucleoprotein H isoform y
NM_005520.3 NP_005511.1 heterogeneous nuclear ribonucleoprotein H isoform a

HNRNPH1 Protein Structure

(14 - 84)

(113 - 182)

zf-RNPHF

zf-RNPHF: RNPHF zinc finger (255 - 290)

(291 - 358)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 449 a.a.
Protein Preferred Names Protein Names

heterogeneous nuclear ribonucleoprotein H

epididymis secretory sperm binding protein

Recombinant HNRNPH1 Proteins

Cat. No. Product Name Accession Purity
HY-P72233 HNRNPH1 Protein, Human (His-SUMO) P31943 (M2-A449) ≥95%

Related Diseases

Diseases Alias
Neurodevelopmental Disorder With Craniofacial Dysmorphism And Skeletal Defects

NEDCDS
Precursor T-Cell Acute Lymphoblastic Leukemia

T-All

Precursor T-Cell Acute Lymphoblastic Leukemia/Lymphoma

Precursor T-Cell Acute Lymphocytic Leukemia

Precursor T-Cell Acute Lymphocytic Leukemia/Lymphoma

Precursor T-Cell Lymphoblastic Leukemia-Lymphoma

Adult T-Cell Lymphoma/Leukemia
Bain Type Of X-Linked Syndromic Intellectual Disability

Intellectual Disability, X-Linked, Syndromic, Bain Type

Hnrnph2 Deficiency
Intellectual Developmental Disorder, X-Linked, Syndromic, Bain Type

MRXSB

Mental Retardation, X-Linked, Syndromic, Bain Type

Intellectual Developmental Disorder, X-Linked Syndromic, Bain Type
Hereditary Lymphedema

Milroy Disease
Myotonic Disease

Myotonic Disorders

Myotonic Syndrome

Symptomatic Myotonia
Myotonic Dystrophy 2

Myotonic Dystrophy Type 2

Proximal Myotonic Myopathy

Promm

Ricker Syndrome

DM2

Dystrophia Myotonica 2

Myotonic Myopathy, Proximal

Myotonic Disorders

Dystrophia Myotonica Type 2

Proximal Myotonic Dystrophy

Ricker Disease

Myotonic Dystrophy, Type 2

Dystrophy, Myotonic, Type 2
Burkitt Lymphoma

Burkitt'S Lymphoma

BL

Burkitt Lymphoma, Somatic

Burkitt Lymphoma/Leukaemia

Burkitt'S Tumor

Burkitt'S Tumor Or Lymphoma

Malignant Lymphoma, Burkitt'S Type

Small Non-Cleaved Cell Lymphoma, Burkitt'S Type

Small Non-Cleaved Cell Lymphoma

Burkitt Tumor

Burkitts Lymphoma

Lymphoma, Small Noncleaved-Cell

Burkitt Tumour

Diffuse Small Noncleaved Malignant Burkitt Lymphoma

Malignant Burkitt Lymphoma

“Burkitt-Like” Lymphoma

Undifferentiated Burkitt Lymphoma

Small Noncleaved Cell Burkitt Lymphoma
Myotonic Dystrophy 1

Myotonic Dystrophy

Dystrophia Myotonica

Steinert Disease

Myotonic Dystrophy Type 1

Myotonia Atrophica

DM1

Congenital Myotonic Dystrophy

Myotonia Dystrophica

Steinert Myotonic Dystrophy

Dystrophia Myotonica 1

Dm

Steinert'S Disease

Steinert Myotonic Dystrophy Syndrome

Myotonic Dystrophy Of Steinert

Dystrophia Myotonica Type 1

Myotonic Dystrophy Congenital

Dystrophy, Myotonic, Type 1

Dm - [Dystrophia Myotonica]

Myotonic Muscular Dystrophy
Spinocerebellar Ataxia 8

Spinocerebellar Ataxia Type 8

SCA8

Ataxia, Spinocerebellar, Type 8
Fragile X-Associated Tremor/Ataxia Syndrome

Fxtas Syndrome

Fragile X Tremor/Ataxia Syndrome

Fxtas
Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 1

FTDALS1

Frontotemporal Dementia And/Or Motor Neuron Disease

Ftdmnd

Amyotrophic Lateral Sclerosis And/Or Frontotemporal Dementia

Alsftd

Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis

Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis-1

Frontotemporal Dementia With Motor Neuron Disease

Ftdals

Ftd-Als

Ftd-Mnd

Frontotemporal Dementia With Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis With Frontotemporal Dementia 1

Amyotrophic Lateral Sclerosis/Frontotemporal Dementia

Dementia, Frontotemporal, And/Or Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis And/Or Frontotemporal Dementia 1

Frontotemporal Lobar Degeneration

Grn-Related Frontotemporal Dementia
Congenital Myasthenic Syndrome

Congenital Myasthenia

Congenital Myasthenic Syndromes

Cms

Myasthenic Syndromes, Congenital

Myasthenic Syndromes Congenital

Myasthenic Syndrome, Congenital

Congenital Myasthenic Syndrome Ib

Congenital And Developmental Myasthenia

Developmental Myasthenia
Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis

ALS

Lou Gehrig Disease

Amyotrophic Lateral Sclerosis Type 1

Charcot Disease

ALS1

Amyotrophic Lateral Sclerosis, Susceptibility To

Fals

Lou Gehrig'S Disease

Mnd

Motor Neuron Disease

Familial Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis 1, Familial

Amyotrophic Lateral Sclerosis 1, Autosomal Dominant

Motor Neuron Disease, Bulbar

Motor Neurone Disease

Amyotrophic Lateral Sclerosis With Dementia

Dementia With Amyotrophic Lateral Sclerosis

Motor Neuron Disease, Amyotrophic Lateral Sclerosis

Sclerosis, Lateral, Amyotrophic

Sclerosis, Lateral, Amyotrophic, Type 1

Amyotrophic Sclerosis

Als - [Amyotrophic Lateral Sclerosis]

Wasting Palsy

Amyotrophic Paralysis

Amyotrophy Lateral Sclerosis

Wasting Paralysis

Spinal Progressive Amyotrophy

Progressive Atrophic Paralysis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS06270 HNRNPH1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus HNRNPH1 RGD RGD:620840
Mus musculus HNRNPH1 MGD MGI:1891925
Canis familiaris HNRNPH1 VGNC VGNC:51723
Felis catus HNRNPH1 VGNC VGNC:67607
Bos taurus HNRNPH1 VGNC VGNC:52245
Macaca mulatta HNRNPH1 VGNC VGNC:84387
Others HNRNPH1 NCBI