2. Gene
  3. HNRNPH1 - heterogeneous nuclear ribonucleoprotein H1 Gene

HNRNPH1 - heterogeneous nuclear ribonucleoprotein H1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as HNRPH; HNRPH1; NEDCDS; hnRNPH

Gene ID: 3187 | Gene type: protein coding

About HNRNPH1

Cytogenetic location: 5q35.3 Genomic coordinates (GRCh38): 5:179,614,178-179,634,784 (from NCBI)

This gene has 50 transcripts (splice variants), 1 gene allele, 143 orthologues, 8 paralogues and is associated with 2 phenotypes. Ubiquitous expression in bone marrow (RPKM 153.8), lymph node (RPKM 101.7) and 25 other tissues.

Summary

This gene encodes a member of a subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins that complex with heterogeneous nuclear RNA. These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and Other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some may shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that bind to RNA and is very similar to the family member HNRPF. This gene may be associated with hereditary lymphedema type I. Alternatively spliced transcript variants have been described [provided by RefSeq, Mar 2012]

HNRNPH1 Products(52)

mRNA Protein Name
NM_001257293.2 NP_001244222.1 heterogeneous nuclear ribonucleoprotein H isoform a
NM_001363572.2 NP_001350501.1 heterogeneous nuclear ribonucleoprotein H isoform b
NM_001364225.2 NP_001351154.1 heterogeneous nuclear ribonucleoprotein H isoform c
NM_001364226.2 NP_001351155.1 heterogeneous nuclear ribonucleoprotein H isoform c
NM_001364227.2 NP_001351156.1 heterogeneous nuclear ribonucleoprotein H isoform c
NM_001364228.2 NP_001351157.1 heterogeneous nuclear ribonucleoprotein H isoform c
NM_001364229.2 NP_001351158.1 heterogeneous nuclear ribonucleoprotein H isoform c
NM_001364230.2 NP_001351159.1 heterogeneous nuclear ribonucleoprotein H isoform d
NM_001364231.2 NP_001351160.1 heterogeneous nuclear ribonucleoprotein H isoform l
NM_001364232.2 NP_001351161.1 heterogeneous nuclear ribonucleoprotein H isoform d
NM_001364233.2 NP_001351162.1 heterogeneous nuclear ribonucleoprotein H isoform a
NM_001364234.2 NP_001351163.1 heterogeneous nuclear ribonucleoprotein H isoform a
NM_001364235.2 NP_001351164.1 heterogeneous nuclear ribonucleoprotein H isoform a
NM_001364236.2 NP_001351165.1 heterogeneous nuclear ribonucleoprotein H isoform a
NM_001364237.2 NP_001351166.1 heterogeneous nuclear ribonucleoprotein H isoform a
NM_001364238.2 NP_001351167.1 heterogeneous nuclear ribonucleoprotein H isoform a
NM_001364239.2 NP_001351168.1 heterogeneous nuclear ribonucleoprotein H isoform a
NM_001364240.2 NP_001351169.1 heterogeneous nuclear ribonucleoprotein H isoform e
NM_001364241.2 NP_001351170.1 heterogeneous nuclear ribonucleoprotein H isoform f
NM_001364242.2 NP_001351171.1 heterogeneous nuclear ribonucleoprotein H isoform f
NM_001364243.2 NP_001351172.1 heterogeneous nuclear ribonucleoprotein H isoform f
NM_001364244.2 NP_001351173.1 heterogeneous nuclear ribonucleoprotein H isoform g
NM_001364245.2 NP_001351174.1 heterogeneous nuclear ribonucleoprotein H isoform b
NM_001364246.2 NP_001351175.1 heterogeneous nuclear ribonucleoprotein H isoform t
NM_001364247.2 NP_001351176.1 heterogeneous nuclear ribonucleoprotein H isoform t
NM_001364248.2 NP_001351177.1 heterogeneous nuclear ribonucleoprotein H isoform h
NM_001364250.2 NP_001351179.1 heterogeneous nuclear ribonucleoprotein H isoform i
NM_001364251.2 NP_001351180.1 heterogeneous nuclear ribonucleoprotein H isoform j
NM_001364252.2 NP_001351181.1 heterogeneous nuclear ribonucleoprotein H isoform j
NM_001364253.2 NP_001351182.1 heterogeneous nuclear ribonucleoprotein H isoform j
NM_001364254.2 NP_001351183.1 heterogeneous nuclear ribonucleoprotein H isoform k
NM_001364255.2 NP_001351184.1 heterogeneous nuclear ribonucleoprotein H isoform k
NM_001395176.1 NP_001382105.1 heterogeneous nuclear ribonucleoprotein H isoform l
NM_001395177.1 NP_001382106.1 heterogeneous nuclear ribonucleoprotein H isoform m
NM_001395178.1 NP_001382107.1 heterogeneous nuclear ribonucleoprotein H isoform n
NM_001395179.1 NP_001382108.1 heterogeneous nuclear ribonucleoprotein H isoform o
NM_001395180.1 NP_001382109.1 heterogeneous nuclear ribonucleoprotein H isoform o
NM_001395181.1 NP_001382110.1 heterogeneous nuclear ribonucleoprotein H isoform p
NM_001395182.1 NP_001382111.1 heterogeneous nuclear ribonucleoprotein H isoform a
NM_001395183.1 NP_001382112.1 heterogeneous nuclear ribonucleoprotein H isoform q
NM_001395184.1 NP_001382113.1 heterogeneous nuclear ribonucleoprotein H isoform r
NM_001395186.1 NP_001382115.1 heterogeneous nuclear ribonucleoprotein H isoform f
NM_001395187.1 NP_001382116.1 heterogeneous nuclear ribonucleoprotein H isoform g
NM_001395188.1 NP_001382117.1 heterogeneous nuclear ribonucleoprotein H isoform s
NM_001395189.1 NP_001382118.1 heterogeneous nuclear ribonucleoprotein H isoform b
NM_001395190.1 NP_001382119.1 heterogeneous nuclear ribonucleoprotein H isoform u
NM_001395191.1 NP_001382120.1 heterogeneous nuclear ribonucleoprotein H isoform v
NM_001395192.1 NP_001382121.1 heterogeneous nuclear ribonucleoprotein H isoform w
NM_001395193.1 NP_001382122.1 heterogeneous nuclear ribonucleoprotein H isoform x
NM_001395194.1 NP_001382123.1 heterogeneous nuclear ribonucleoprotein H isoform k
NM_001395195.1 NP_001382124.1 heterogeneous nuclear ribonucleoprotein H isoform y
NM_005520.3 NP_005511.1 heterogeneous nuclear ribonucleoprotein H isoform a
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables RNA binding IDA
IDA: Inferred from direct assay
16946708 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
9111328 GOA
Biological Process GO Annotation Evidence Reference Source
involved in regulation of RNA splicing IDA
IDA: Inferred from direct assay
16946708 GOA
Cellular Component GO Annotation Evidence Reference Source
part of catalytic step 2 spliceosome IDA
IDA: Inferred from direct assay
11991638 GOA
located in nucleus IDA
IDA: Inferred from direct assay
24910439 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HNRNPH1 Protein Structure

(14 - 84)

(113 - 182)

zf-RNPHF

zf-RNPHF: RNPHF zinc finger (255 - 290)

(291 - 358)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 449 a.a.
Protein Preferred Names Protein Names

heterogeneous nuclear ribonucleoprotein H

epididymis secretory sperm binding protein

HNRNPH1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
HNRNPH1 P31943 UBE2I Homo sapiens Q7KZS0
Y2H Array
32296183
Intra
HNRNPH1 P31943 UBE2I Homo sapiens Q7KZS0
Y2H Prey Pooling
32296183
Intra
HNRNPH1 P31943 UBE2I Homo sapiens Q7KZS0
Validated Y2H
32296183
Intra
HNRNPH1 P31943 NFKBID Homo sapiens Q8NI38
Y2H Prey Pooling
32296183
Intra
HNRNPH1 P31943 NFKBID Homo sapiens Q8NI38
Y2H Array
32296183
Intra
HNRNPH1 P31943 NFKBID Homo sapiens Q8NI38
Validated Y2H
32296183
Intra
HNRNPH1 P31943 POLR1C Homo sapiens O15160
MAPPIT
32296183
Intra
HNRNPH1 P31943 ARHGEF16 Homo sapiens Q5VV41
Validated Y2H
32296183
Intra
HNRNPH1 P31943 PATZ1 Homo sapiens Q9HBE1-4
Y2H Prey Pooling
32296183
Intra
HNRNPH1 P31943 PATZ1 Homo sapiens Q9HBE1-4
Validated Y2H
32296183
Intra
HNRNPH1 P31943 PATZ1 Homo sapiens Q9HBE1-4
Y2H Array
32296183
Intra
HNRNPH1 P31943 LMO3 Homo sapiens Q8TAP4-4
Validated Y2H
32296183
Intra
HNRNPH1 P31943 KRTAP13-2 Homo sapiens Q52LG2
Validated Y2H
32296183
Intra
HNRNPH1 P31943 KRTAP13-2 Homo sapiens Q52LG2
Y2H Array
32296183
Intra
HNRNPH1 P31943 KRTAP13-2 Homo sapiens Q52LG2
Y2H Prey Pooling
32296183
Intra
HNRNPH1 P31943 RBFOX2 Homo sapiens O43251-10
Y2H Array
32296183
Intra
HNRNPH1 P31943 RBFOX2 Homo sapiens O43251-10
Y2H Prey Pooling
32296183
Intra
HNRNPH1 P31943 SAXO4 Homo sapiens Q7Z5V6-2
Validated Y2H
32296183
Intra
HNRNPH1 P31943 PEX5 Homo sapiens P50542-3
Y2H Prey Pooling
32296183
Intra
HNRNPH1 P31943 PEX5 Homo sapiens P50542-3
Validated Y2H
32296183
Intra
HNRNPH1 P31943 PEX5 Homo sapiens P50542-3
Y2H Array
32296183
Intra
HNRNPH1 P31943 OXER1 Homo sapiens Q8TDS5
Y2H Prey Pooling
32296183
Intra
HNRNPH1 P31943 OXER1 Homo sapiens Q8TDS5
Validated Y2H
32296183
Intra
HNRNPH1 P31943 OXER1 Homo sapiens Q8TDS5
Y2H Array
32296183
Intra
HNRNPH1 P31943 RNF4 Homo sapiens P78317
Y2H Prey Pooling
32296183
Intra
HNRNPH1 P31943 RNF4 Homo sapiens P78317
Validated Y2H
32296183
Intra
HNRNPH1 P31943 RNF4 Homo sapiens P78317
Y2H Array
32296183
Intra
HNRNPH1 P31943 MSI2 Homo sapiens Q96DH6
Anti Tag CoIP
35271311
Intra
HNRNPH1 P31943 MSI2 Homo sapiens Q96DH6
Y2H Prey Pooling
32296183
Intra
HNRNPH1 P31943 MSI2 Homo sapiens Q96DH6
Validated Y2H
32296183
Intra
HNRNPH1 P31943 MSI2 Homo sapiens Q96DH6
Y2H Array
32296183
Intra
HNRNPH1 P31943 MRPL53 Homo sapiens Q96EL3
Anti Tag CoIP
35271311
Intra
HNRNPH1 P31943 MRPL53 Homo sapiens Q96EL3
Validated Y2H
32296183
Intra
HNRNPH1 P31943 RBM38 Homo sapiens Q9H0Z9
Y2H Prey Pooling
32296183
Intra
HNRNPH1 P31943 RBM38 Homo sapiens Q9H0Z9
Y2H Array
32296183
Intra
HNRNPH1 P31943 RBM38 Homo sapiens Q9H0Z9
Validated Y2H
32296183
Intra
HNRNPH1 P31943 MYPOP Homo sapiens Q86VE0
Validated Y2H
32296183
Intra
HNRNPH1 P31943 NUDT16L1 Homo sapiens Q9BRJ7
Validated Y2H
32296183
Intra
HNRNPH1 P31943 NUDT16L1 Homo sapiens Q9BRJ7
Anti Tag CoIP
35271311
Intra
HNRNPH1 P31943 HNRNPF Homo sapiens P52597
Validated Y2H
32296183
Intra
HNRNPH1 P31943 HNRNPM Homo sapiens P52272
Y2H Prey Pooling
32296183
Intra
HNRNPH1 P31943 HNRNPM Homo sapiens P52272
Validated Y2H
32296183
Intra
HNRNPH1 P31943 HNRNPF Homo sapiens P52597
Anti Tag CoIP
35271311
Intra
HNRNPH1 P31943 TARDBP Homo sapiens Q13148
Y2H Array
32814053
Intra
HNRNPH1 P31943 TARDBP Homo sapiens Q13148
Anti Tag CoIP
29725819
Intra
HNRNPH1 P31943 HNRNPM Homo sapiens P52272
Y2H Array
32296183
Intra
HNRNPH1 P31943 HNRNPM Homo sapiens P52272
Anti Tag CoIP
35271311
Intra
HNRNPH1 P31943 TARDBP Homo sapiens Q13148
Y2H Pooling
32814053
Intra
HNRNPH1 P31943 HNRNPA1 Homo sapiens P09651
Anti Tag CoIP
35271311
Intra
HNRNPH1 P31943 TARDBP Homo sapiens Q13148
Validated Y2H
32814053
Intra
HNRNPH1 P31943 GPS2 Homo sapiens Q13227
Validated Y2H
32296183
Intra
HNRNPH1 P31943 MAGED1 Homo sapiens Q9Y5V3
Validated Y2H
32296183
Intra
HNRNPH1 P31943 MAGED1 Homo sapiens Q9Y5V3
Y2H Array
32296183
Intra
HNRNPH1 P31943 MAGED1 Homo sapiens Q9Y5V3
Y2H Prey Pooling
32296183
Intra
HNRNPH1 P31943 LNX1 Homo sapiens Q8TBB1
Validated Y2H
32296183
Intra
HNRNPH1 P31943 LNX1 Homo sapiens Q8TBB1
Y2H Prey Pooling
32296183
Intra
HNRNPH1 P31943 LNX1 Homo sapiens Q8TBB1
Y2H Array
32296183
Intra
HNRNPH1 P31943 SPG21 Homo sapiens Q9NZD8
Validated Y2H
32296183
Intra
HNRNPH1 P31943 RAMAC Homo sapiens Q9BTL3
Validated Y2H
32296183
Intra
HNRNPH1 P31943 ENKD1 Homo sapiens Q9H0I2
Validated Y2H
32296183
Intra
HNRNPH1 P31943 CATSPER1 Homo sapiens Q8NEC5
Validated Y2H
32296183
Intra
HNRNPH1 P31943 CCDC120 Homo sapiens Q96HB5
Validated Y2H
32296183
Intra
HNRNPH1 P31943 DDX17 Homo sapiens Q92841
Y2H Prey Pooling
32296183
Intra
HNRNPH1 P31943 DDX17 Homo sapiens Q92841
Validated Y2H
32296183
Intra
HNRNPH1 P31943 DDX17 Homo sapiens Q92841
Y2H Array
32296183
Intra
HNRNPH1 P31943 TEKT4 Homo sapiens Q8WW24
Validated Y2H
32296183
Intra
HNRNPH1 P31943 TEKT3 Homo sapiens Q9BXF9
Validated Y2H
32296183
Intra
HNRNPH1 P31943 DZIP3 Homo sapiens Q86Y13
Validated Y2H
32296183
Intra
HNRNPH1 P31943 DZIP3 Homo sapiens Q86Y13
Y2H Prey Pooling
32296183
Intra
HNRNPH1 P31943 DZIP3 Homo sapiens Q86Y13
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant HNRNPH1 Proteins

Cat. No. Product Name Accession Purity
HY-P72233 HNRNPH1 Protein, Human (His-SUMO) P31943 (M2-A449) ≥95%

Related Diseases

Diseases Alias
Neurodevelopmental Disorder With Craniofacial Dysmorphism And Skeletal Defects

NEDCDS
Precursor T-Cell Acute Lymphoblastic Leukemia

T-All

Precursor T-Cell Acute Lymphoblastic Leukemia/Lymphoma

Precursor T-Cell Acute Lymphocytic Leukemia

Precursor T-Cell Acute Lymphocytic Leukemia/Lymphoma

Precursor T-Cell Lymphoblastic Leukemia-Lymphoma

Adult T-Cell Lymphoma/Leukemia
Bain Type Of X-Linked Syndromic Intellectual Disability

Intellectual Disability, X-Linked, Syndromic, Bain Type

Hnrnph2 Deficiency
Intellectual Developmental Disorder, X-Linked, Syndromic, Bain Type

MRXSB

Mental Retardation, X-Linked, Syndromic, Bain Type

Intellectual Developmental Disorder, X-Linked Syndromic, Bain Type
Hereditary Lymphedema

Milroy Disease
Myotonic Disease

Myotonic Disorders

Myotonic Syndrome

Symptomatic Myotonia
Myotonic Dystrophy 2

Myotonic Dystrophy Type 2

Proximal Myotonic Myopathy

Promm

Ricker Syndrome

DM2

Dystrophia Myotonica 2

Myotonic Myopathy, Proximal

Myotonic Disorders

Dystrophia Myotonica Type 2

Proximal Myotonic Dystrophy

Ricker Disease

Myotonic Dystrophy, Type 2

Dystrophy, Myotonic, Type 2
Burkitt Lymphoma

Burkitt'S Lymphoma

BL

Burkitt Lymphoma, Somatic

Burkitt Lymphoma/Leukaemia

Burkitt'S Tumor

Burkitt'S Tumor Or Lymphoma

Malignant Lymphoma, Burkitt'S Type

Small Non-Cleaved Cell Lymphoma, Burkitt'S Type

Small Non-Cleaved Cell Lymphoma

Burkitt Tumor

Burkitts Lymphoma

Lymphoma, Small Noncleaved-Cell

Burkitt Tumour

Diffuse Small Noncleaved Malignant Burkitt Lymphoma

Malignant Burkitt Lymphoma

“Burkitt-Like” Lymphoma

Undifferentiated Burkitt Lymphoma

Small Noncleaved Cell Burkitt Lymphoma
Myotonic Dystrophy 1

Myotonic Dystrophy

Dystrophia Myotonica

Steinert Disease

Myotonic Dystrophy Type 1

Myotonia Atrophica

DM1

Congenital Myotonic Dystrophy

Myotonia Dystrophica

Steinert Myotonic Dystrophy

Dystrophia Myotonica 1

Dm

Steinert'S Disease

Steinert Myotonic Dystrophy Syndrome

Myotonic Dystrophy Of Steinert

Dystrophia Myotonica Type 1

Myotonic Dystrophy Congenital

Dystrophy, Myotonic, Type 1

Dm - [Dystrophia Myotonica]

Myotonic Muscular Dystrophy
Spinocerebellar Ataxia 8

Spinocerebellar Ataxia Type 8

SCA8

Ataxia, Spinocerebellar, Type 8
Fragile X-Associated Tremor/Ataxia Syndrome

Fxtas Syndrome

Fragile X Tremor/Ataxia Syndrome

Fxtas
Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 1

FTDALS1

Frontotemporal Dementia And/Or Motor Neuron Disease

Ftdmnd

Amyotrophic Lateral Sclerosis And/Or Frontotemporal Dementia

Alsftd

Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis

Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis-1

Frontotemporal Dementia With Motor Neuron Disease

Ftdals

Ftd-Als

Ftd-Mnd

Frontotemporal Dementia With Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis With Frontotemporal Dementia 1

Amyotrophic Lateral Sclerosis/Frontotemporal Dementia

Dementia, Frontotemporal, And/Or Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis And/Or Frontotemporal Dementia 1

Frontotemporal Lobar Degeneration

Grn-Related Frontotemporal Dementia
Congenital Myasthenic Syndrome

Congenital Myasthenia

Congenital Myasthenic Syndromes

Cms

Myasthenic Syndromes, Congenital

Myasthenic Syndromes Congenital

Myasthenic Syndrome, Congenital

Congenital Myasthenic Syndrome Ib

Congenital And Developmental Myasthenia

Developmental Myasthenia
Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis

ALS

Lou Gehrig Disease

Amyotrophic Lateral Sclerosis Type 1

Charcot Disease

ALS1

Amyotrophic Lateral Sclerosis, Susceptibility To

Fals

Lou Gehrig'S Disease

Mnd

Motor Neuron Disease

Familial Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis 1, Familial

Amyotrophic Lateral Sclerosis 1, Autosomal Dominant

Motor Neuron Disease, Bulbar

Motor Neurone Disease

Amyotrophic Lateral Sclerosis With Dementia

Dementia With Amyotrophic Lateral Sclerosis

Motor Neuron Disease, Amyotrophic Lateral Sclerosis

Sclerosis, Lateral, Amyotrophic

Sclerosis, Lateral, Amyotrophic, Type 1

Amyotrophic Sclerosis

Als - [Amyotrophic Lateral Sclerosis]

Wasting Palsy

Amyotrophic Paralysis

Amyotrophy Lateral Sclerosis

Wasting Paralysis

Spinal Progressive Amyotrophy

Progressive Atrophic Paralysis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS06270 HNRNPH1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus HNRNPH1 RGD RGD:620840
Mus musculus HNRNPH1 MGD MGI:1891925
Canis familiaris HNRNPH1 VGNC VGNC:51723
Felis catus HNRNPH1 VGNC VGNC:67607
Bos taurus HNRNPH1 VGNC VGNC:52245
Macaca mulatta HNRNPH1 VGNC VGNC:84387
Others HNRNPH1 NCBI